Hub : Genes

Atf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XM_039079335.2 0.02 0.02 3.4e-03 0.01 0.01 0.01 0.01 3.0e-02 3.3e-02 3.3e-02 5.4e-02
2 Brain mRNA stability Atf1 0.06 0.04 3.1e-06 0.06 0.06 0.06 0.06 2.1e-06 2.3e-06 4.2e-06 6.2e-06
3 Adipose gene expression Atf1 0.03 0.02 2.4e-04 0.03 0.02 0.02 0.02 2.4e-04 9.7e-04 4.1e-03 1.3e-03
4 RMTg alternative TSS NM_001100895.1 0.17 0.12 7.8e-04 0.06 0 0.02 0.04 1.3e-02 2.4e-01 7.5e-02 4.2e-02
5 RMTg alternative TSS XM_039079335.2 0.17 0.11 6.6e-04 0.06 0.01 0.03 0.03 8.4e-03 1.9e-01 5.7e-02 6.8e-02
6 NAcc mRNA stability Atf1 0.01 0.01 1.9e-03 0.02 0.01 0.01 0.02 8.4e-04 2.0e-03 2.4e-03 1.3e-03
7 RMTg alternative TSS NM_001100895.1 0.17 0.11 6.4e-04 0.06 0 0.03 0.04 9.9e-03 2.3e-01 5.0e-02 2.6e-02
8 Adipose mRNA stability Atf1 0.04 0.03 2.2e-05 0.03 0.03 0.02 0.02 3.4e-04 5.3e-04 2.3e-03 1.1e-03
9 Adipose intron excision ratio chr7_133264263_133265779 0.03 0.02 1.5e-04 0.03 0.03 0.03 0.03 1.7e-04 1.8e-04 1.4e-04 2.2e-04
10 Liver isoform ratio XM_063263673.1 0.03 0.02 7.7e-04 0.02 0.03 0.01 0.02 9.7e-04 8.5e-04 1.4e-02 1.6e-03
11 Adipose intron excision ratio chr7_133270913_133275586 0.02 0.02 2.4e-03 0.01 0.01 0.01 0.01 1.6e-02 1.7e-02 5.5e-02 4.2e-02
12 Liver isoform ratio XM_039079335.2 0.03 0.02 3.8e-04 0.02 0.01 0 0.01 1.8e-03 7.0e-03 1.2e-01 1.2e-02
13 Liver mRNA stability Atf1 0.08 0.06 2.7e-09 0.06 0.06 0.07 0.06 3.0e-07 1.2e-07 7.4e-08 2.4e-07
14 Liver intron excision ratio chr7_133270913_133275586 0.07 0.04 1.0e-08 0.08 0.07 0.06 0.07 2.1e-09 7.6e-08 2.0e-07 1.7e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density5.69.711.4-3.13.13.1-3.23.23.3-3.23.2-2.82.9-3.3-3.32.0-3.4
Area under the delay curve0.91.02.6-0.70.40.4-1.11.10.9-1.11.1-0.91.1-1.6-1.60.90.0
BMI with tail6.120.928.8-5.45.45.4-4.44.44.5-4.74.5-5.24.7-4.1-4.14.70.0
BMI without tail1.65.07.8-2.82.82.8-2.12.12.2-2.22.2-2.72.2-1.8-1.82.00.0
Body weight6.026.232.9-5.75.75.7-5.25.25.3-5.45.3-5.65.2-4.7-4.75.20.0
Weight adjusted by age0.40.61.3-0.91.01.0-0.70.70.8-0.80.7-0.91.1-0.6-0.6-0.00.0
Bone surface8.114.716.2-4.04.04.0-3.93.93.9-3.83.9-3.73.5-3.8-3.83.4-3.9
Bone volume7.413.314.7-3.73.73.7-3.83.83.8-3.73.7-3.43.4-3.8-3.82.9-3.8
Breakpoint value in progressive ratio session0.50.61.1-1.01.01.0-0.80.80.8-0.80.6-1.00.7-0.5-0.50.90.0
Number of licking bursts1.11.73.11.8-1.8-1.81.0-1.0-1.31.4-1.01.4-0.91.31.3-0.71.3
Context. condit. distance diff. score0.40.51.1-1.11.11.1-0.60.60.4-0.40.6-1.00.5-0.4-0.40.6-0.3
Locomotion velocity, session 14.04.35.01.8-1.8-1.82.2-2.2-2.12.1-2.22.0-2.12.12.1-2.22.2
Locomotion distance, session 12.83.64.11.9-1.9-1.91.9-1.9-1.91.9-1.92.0-1.81.91.9-1.72.0
Locomotion velocity, session 20.40.50.70.7-0.7-0.70.7-0.7-0.60.6-0.70.9-0.70.60.6-0.70.6
Locomotion distance, session 23.44.76.32.5-2.5-2.52.1-2.1-2.12.1-2.12.5-2.12.02.0-1.92.0
Locomotion velocity, session 35.05.76.42.5-2.5-2.52.3-2.3-2.32.4-2.32.4-2.52.32.3-2.12.5
Locomotion distance, session 33.03.35.51.8-1.8-1.81.7-1.7-1.71.7-1.71.6-2.11.71.7-2.31.9
Stereotopy head waving bouts, day 30.10.10.30.4-0.4-0.40.0-0.00.1-0.1-0.00.30.3-0.1-0.10.5-0.0
Stereotopy head waving duration, day 30.20.20.70.8-0.8-0.80.3-0.3-0.20.2-0.30.7-0.20.10.10.40.2
Locomotion velocity, session 73.03.34.51.8-1.8-1.81.9-1.9-1.81.7-1.91.8-2.11.81.8-1.71.7
Locomotion distance, session 73.94.96.32.3-2.3-2.32.2-2.2-2.22.2-2.22.2-2.52.22.2-1.92.1
Stereotopy head waving bouts, day 70.91.01.8-1.11.11.1-0.80.81.0-0.80.8-1.01.3-1.0-1.00.6-0.9
Stereotopy head waving duration, day 71.01.22.0-1.11.11.1-1.01.01.2-1.11.0-1.01.4-1.2-1.20.9-1.1
Locomotion velocity, session 80.40.40.70.4-0.4-0.40.9-0.9-0.60.6-0.90.5-0.70.70.7-0.70.6
Locomotion distance, session 80.91.41.90.9-0.9-0.91.2-1.2-1.31.4-1.21.0-1.31.31.3-1.11.3
Degree of sensitization distance0.10.10.7-0.20.20.2-0.00.0-0.0-0.00.0-0.10.20.00.00.8-0.2
Degree of sensitization stereotypy1.01.01.8-1.31.31.3-0.80.81.0-0.80.8-1.21.3-1.0-1.00.5-0.8
Conditioned locomotion0.20.20.60.8-0.8-0.80.2-0.2-0.30.4-0.20.8-0.50.20.2-0.50.2
Cocaine response after cond. corrected0.00.00.10.3-0.3-0.30.1-0.1-0.10.1-0.10.3-0.00.00.0-0.0-0.1
Cocaine response after cond. not corrected0.30.30.40.6-0.6-0.60.5-0.5-0.60.6-0.50.6-0.50.50.5-0.50.5
Cocaine response before conditioning1.72.03.21.1-1.1-1.11.5-1.5-1.51.6-1.41.3-1.61.51.5-1.21.8
Saline control response0.00.10.20.2-0.2-0.20.2-0.2-0.20.2-0.10.2-0.40.30.3-0.30.2
Bone: connectivity density2.84.45.1-2.22.22.2-2.12.12.2-2.12.1-1.91.8-2.2-2.21.4-2.3
Bone: cortical apparent density0.20.30.60.7-0.7-0.70.5-0.5-0.40.3-0.50.8-0.30.30.3-0.40.1
Bone: cortical area5.88.99.5-3.13.13.1-3.03.03.0-2.92.9-3.12.9-3.0-3.02.6-3.0
Bone: cortical porosity0.10.10.2-0.30.30.3-0.40.40.2-0.10.5-0.30.0-0.0-0.00.0-0.1
Bone: cortical porosity0.00.00.10.0-0.0-0.0-0.20.20.00.10.2-0.0-0.20.10.1-0.2-0.0
Bone: cortical thickness1.93.13.8-1.91.91.9-1.71.71.7-1.71.6-1.91.7-1.8-1.81.6-1.8
Bone: cortical thickness0.30.30.90.4-0.4-0.40.6-0.6-0.60.5-0.50.3-0.70.60.6-1.00.4
Bone: cortical tissue density0.30.40.80.8-0.8-0.80.6-0.6-0.50.4-0.60.9-0.40.40.4-0.50.2
Condit. Reinf. active minus inactive responses0.10.10.2-0.40.40.40.2-0.2-0.30.3-0.2-0.4-0.10.40.4-0.20.2
Condit. Reinf. active-inactive response ratio0.20.30.6-0.70.70.7-0.50.50.3-0.30.5-0.70.3-0.3-0.30.3-0.4
Condit. Reinf. active responses0.50.61.00.3-0.3-0.30.9-0.9-0.91.0-0.90.2-0.61.01.0-0.80.9
Condit. Reinf. inactive responses2.53.13.61.7-1.7-1.71.9-1.9-1.81.7-1.91.7-1.51.81.8-1.51.9
Incentive salience index mean0.20.20.8-0.90.90.9-0.10.10.00.00.1-0.90.40.00.0-0.0-0.1
Condit. Reinf. lever presses0.60.91.7-1.21.21.2-0.80.80.7-0.70.8-1.31.1-0.6-0.60.6-0.7
Condit. Reinf. active minus inactive responses1.01.31.7-1.31.31.3-1.11.11.1-0.91.1-1.21.2-1.2-1.21.2-1.0
Condit. Reinf. active-inactive response ratio0.80.91.4-1.01.01.0-0.90.91.0-0.80.9-1.00.9-1.1-1.11.2-0.9
Condit. Reinf. active responses0.10.20.4-0.70.70.7-0.40.40.3-0.30.4-0.60.5-0.4-0.40.3-0.3
Condit. Reinf. inactive responses0.60.71.40.4-0.4-0.41.0-1.0-1.00.8-1.00.6-0.81.01.0-1.21.0
Condit. Reinf. lever presses0.00.00.10.3-0.3-0.3-0.00.00.0-0.0-0.00.2-0.20.00.00.30.1
Condit. Reinf. lever reinforcers received0.00.00.1-0.30.30.30.0-0.0-0.10.10.0-0.20.10.00.00.00.1
Conditioned reinforcement - actives0.50.81.81.4-1.2-1.20.8-0.8-0.80.8-0.81.1-1.00.80.8-0.20.0
Conditioned reinforcement - inactives3.75.56.82.6-2.6-2.62.5-2.5-2.42.5-2.32.2-2.42.32.3-2.50.0
Conditioned locomotion0.30.30.90.8-0.7-0.70.4-0.4-0.50.5-0.50.6-0.7-0.0-0.01.00.0
Patch foraging indifference point 0 sec4.58.310.82.4-2.4-2.43.0-3.0-3.33.2-3.02.4-3.13.13.1-2.83.0
Patch foraging indifference point AUC0.60.91.41.0-1.0-1.01.0-1.0-0.90.9-1.01.2-0.70.70.7-1.00.6
Delay disc. indifference point, 0s delay1.41.52.5-1.10.80.8-1.51.51.5-1.51.6-1.31.4-1.3-1.30.80.0
Delay disc. indifference point, 16s delay0.70.71.7-0.70.50.5-0.90.90.8-0.90.8-0.90.8-1.3-1.30.90.0
Delay disc. indifference point, 2s delay1.71.93.3-1.41.11.1-1.41.41.3-1.51.5-1.41.8-1.8-1.80.80.0
Delay disc. indifference point, 24s delay0.40.41.2-0.60.40.4-0.70.70.6-0.60.6-0.60.7-1.1-1.10.50.0
Delay disc. indifference point, 4s delay1.21.32.9-0.90.80.8-1.11.11.1-1.31.2-1.11.2-1.7-1.70.70.0
Delay disc. indifference point, 8s delay0.80.91.8-0.70.40.4-1.11.11.0-1.11.1-0.90.9-1.3-1.31.20.0
Indifference point function ln k3.86.77.4-2.62.62.6-2.62.62.5-2.62.6-2.72.4-2.5-2.52.7-2.6
Indifference point function log k3.86.77.4-2.62.62.6-2.62.62.5-2.62.6-2.72.4-2.5-2.52.7-2.6
Patch foraging total patch changes 0 sec4.27.810.12.4-2.4-2.42.9-2.9-3.23.1-3.02.4-3.12.92.9-2.62.8
Patch foraging total patch changes 12 sec5.57.18.82.4-2.4-2.42.9-2.9-3.03.0-2.92.5-2.72.72.7-2.22.7
Patch foraging total patch changes 18 sec5.48.29.72.7-2.7-2.73.1-3.1-3.13.0-3.13.0-2.92.82.8-2.82.2
Patch foraging total patch changes 24 sec3.05.16.92.0-2.0-2.02.3-2.3-2.52.5-2.42.1-2.32.32.3-2.61.9
Patch foraging total patch changes 6 sec6.29.411.12.7-2.7-2.73.2-3.2-3.23.3-3.32.8-3.13.13.1-3.23.1
Patch foraging time to switch 0 sec1.83.74.41.7-1.7-1.72.1-2.1-1.92.0-2.11.8-1.82.12.1-2.12.0
Patch foraging water rate 0 sec3.06.27.5-2.52.52.5-2.52.52.4-2.42.5-2.62.4-2.5-2.52.7-2.3
Patch foraging water rate 12 sec1.73.64.7-1.81.81.8-2.12.12.0-2.02.1-1.71.8-1.9-1.91.4-2.2
Patch foraging water rate 18 sec0.30.50.9-0.50.50.5-0.90.90.8-0.61.0-0.50.7-0.9-0.90.4-0.6
Patch foraging water rate 24 sec4.15.87.4-2.22.22.2-2.62.62.7-2.52.6-2.32.4-2.4-2.42.2-2.2
Patch foraging water rate 6 sec5.98.69.6-2.82.82.8-3.13.13.0-2.83.0-2.82.8-3.0-3.02.9-3.1
Seeking ratio, delayed vs. immediate footshock0.40.51.3-0.70.60.6-0.70.70.9-0.60.8-0.70.8-0.3-0.31.10.0
Distance traveled before self-admin1.62.13.01.2-1.3-1.31.7-1.7-1.71.6-1.71.5-1.61.31.3-1.70.0
Distance traveled after self-admin1.01.22.40.6-0.8-0.81.3-1.3-1.11.2-1.21.3-1.61.21.2-1.00.0
Extensor digitorum longus weight5.019.825.5-4.84.84.8-4.24.24.4-4.44.1-4.75.1-4.2-4.23.9-4.2
Bone: elastic displacement6.77.89.22.9-2.9-2.92.8-2.8-2.62.6-2.83.0-3.02.72.7-2.42.6
Bone: elastic work0.20.20.60.7-0.7-0.70.2-0.2-0.10.2-0.30.8-0.60.20.20.10.2
Bone: endosteal estimation6.013.215.5-3.53.53.5-3.93.93.8-3.73.9-3.63.4-3.7-3.73.1-3.5
Bone: endosteal perimeter5.812.313.7-3.33.33.3-3.73.73.7-3.63.7-3.33.4-3.6-3.63.0-3.7
Epididymis fat weight0.20.50.8-0.90.90.9-0.80.80.8-0.90.7-0.80.3-0.3-0.30.90.0
Delta time in closed arm before/after self-admin0.10.10.7-0.30.30.3-0.20.2-0.0-0.10.1-0.20.10.10.10.80.0
Delta time in open arm before/after self-admin1.01.02.00.9-0.8-0.81.2-1.2-1.00.8-1.11.2-1.40.80.8-1.40.0
Diff in mean of infusions in LGA sessions0.91.22.3-1.51.51.5-1.01.00.7-0.50.8-1.11.1-1.0-1.01.30.0
Delay discount exponential model param0.91.12.80.8-0.5-0.51.0-1.0-0.91.1-1.10.9-1.11.71.7-0.90.0
Extinction: sum of active levers before priming2.52.74.8-2.22.02.0-1.71.71.6-1.61.6-1.81.8-0.8-0.82.10.0
Active lever presses in extinction session 60.00.00.1-0.30.20.2-0.20.20.2-0.30.1-0.20.1-0.1-0.1-0.20.0
Bone: final force10.717.218.0-4.24.24.2-4.24.24.2-4.24.2-4.03.8-4.2-4.23.9-4.2
Bone: final moment11.919.120.4-4.44.44.4-4.54.54.5-4.44.4-4.24.0-4.5-4.54.1-4.4
Food consumed during 24 hour testing period1.72.43.8-1.81.81.8-1.61.61.3-1.21.6-1.71.3-1.4-1.41.9-1.3
Glucose0.30.50.80.4-0.4-0.40.9-0.9-0.80.9-0.90.5-0.70.70.7-0.90.0
Heart weight0.20.30.5-0.70.70.7-0.60.60.4-0.40.5-0.60.3-0.3-0.30.40.0
Delay discount hyperbolic model param0.91.02.70.7-0.5-0.51.0-1.0-0.91.1-1.10.9-1.11.61.6-0.80.0
Intermittent access intake day 1-15 change0.00.10.3-0.10.10.1-0.40.40.5-0.40.4-0.30.0-0.1-0.1-0.30.0
Intermittent access intake escalation0.20.40.8-0.50.50.5-0.70.70.9-0.80.8-0.70.5-0.4-0.40.10.0
Intermittent access intake escalation 20.10.10.2-0.30.30.3-0.30.30.4-0.30.3-0.30.10.10.1-0.10.0
Intermitt. access day 1 inactive lever presses0.00.10.30.5-0.4-0.40.3-0.3-0.20.2-0.20.3-0.2-0.1-0.10.60.0
Intermitt. access day 15 inactive lever presses0.00.10.40.0-0.1-0.1-0.10.10.2-0.20.20.2-0.10.10.1-0.60.0
Intermitt. access escalation Index0.00.10.3-0.30.10.1-0.20.20.2-0.10.2-0.10.5-0.1-0.10.40.0
Intermittent access day 1 total infusions0.91.52.61.6-1.6-1.61.2-1.2-1.31.4-1.21.5-1.50.60.6-0.20.0
Intermittent access day 15 total infusions0.40.51.00.9-1.0-1.00.7-0.7-0.70.8-0.70.8-0.90.50.5-0.20.0
Intermittent access terminal intake (last 3 days)0.60.71.31.0-1.2-1.20.9-0.9-0.81.0-0.81.0-1.00.60.6-0.30.0
Intermittent access total infusions1.01.22.01.4-1.4-1.41.2-1.2-1.11.3-1.11.2-1.30.80.8-0.40.0
Intermittent access day 1 locomotion0.91.22.51.6-1.5-1.51.0-1.0-1.21.1-0.91.4-1.40.10.10.10.0
Intermittent access day 15 total locomotion0.40.71.61.3-1.2-1.20.7-0.7-0.70.8-0.60.7-1.2-0.1-0.1-0.70.0
Intermittent access total locomotion2.22.65.32.3-2.2-2.21.6-1.6-1.61.7-1.51.7-2.00.80.8-0.90.0
Intermittent access standard deviation0.10.10.60.2-0.3-0.30.2-0.2-0.30.2-0.30.5-0.70.40.4-0.50.0
Left kidney weight1.36.08.6-2.92.92.9-2.72.72.6-2.52.6-2.62.5-2.0-2.01.80.0
Right kidney weight3.817.424.0-4.94.94.9-4.34.34.3-4.34.3-4.54.3-3.7-3.73.60.0
Cocaine induced anxiety1.62.33.3-1.61.71.7-1.61.61.6-1.71.6-1.51.4-1.3-1.31.80.0
Post-drug Anxiety2.62.84.0-1.61.51.5-1.91.91.9-1.91.9-1.81.6-1.3-1.32.00.0
Baseline Anxiety0.20.30.6-0.20.00.0-0.70.70.7-0.50.7-0.80.7-0.3-0.30.50.0
Tail length0.00.00.10.1-0.1-0.1-0.10.10.00.10.00.1-0.20.10.1-0.30.0
Length with tail1.25.26.6-2.32.32.3-2.52.52.6-2.52.5-2.22.3-2.2-2.22.40.0
Length without tail4.815.518.3-4.04.04.0-4.14.14.1-4.34.1-4.04.0-4.0-4.04.20.0
Times rat made contact with spout0.00.00.1-0.40.40.40.1-0.1-0.00.1-0.1-0.3-0.00.00.00.30.1
Lifetime Intake1.82.13.51.8-1.9-1.91.5-1.5-1.51.7-1.51.6-1.80.90.9-0.60.0
Liver weight, left8.814.517.1-4.04.04.0-4.14.14.0-4.04.1-3.83.7-3.9-3.93.70.0
Liver weight, right2.64.56.1-2.22.22.2-2.52.52.3-2.32.4-2.12.0-1.8-1.82.10.0
Locomotor activity1.32.03.11.1-1.1-1.11.3-1.3-1.51.4-1.41.2-1.31.71.7-1.61.8
Locomotor testing distance2.74.96.51.9-1.9-1.92.2-2.2-2.42.3-2.31.9-2.22.62.6-2.22.5
Locomotor testing rearing1.53.14.51.1-1.1-1.11.8-1.8-1.91.8-1.81.2-1.92.12.1-2.02.1
Locomotion in novel chamber3.95.06.2-1.92.02.0-2.32.32.5-2.52.4-2.42.4-2.4-2.42.50.0
Locomotion in novel chamber post-restriction0.10.20.4-0.10.20.2-0.50.50.6-0.60.6-0.50.3-0.4-0.40.50.0
Fecal boli incidents, locomotor time 10.50.71.50.9-0.6-0.60.9-0.9-1.11.2-0.90.8-1.20.60.6-0.20.0
Change in fecal boli incidents, locomotor task0.00.00.10.1-0.2-0.2-0.10.10.2-0.30.20.10.4-0.2-0.2-0.10.0
Time >=10cm from walls, locomotor time 10.60.61.01.0-1.0-1.00.7-0.7-0.80.8-0.80.9-0.90.60.6-0.40.0
Bouts of movement, locomotor time 10.00.00.10.20.10.1-0.00.0-0.1-0.1-0.00.10.10.30.3-0.10.0
Total resting periods, locomotor time 10.50.51.00.9-0.6-0.60.6-0.6-0.80.6-0.70.8-0.61.01.0-0.70.0
Rest time, locomotor task time 10.91.11.61.2-1.1-1.10.9-0.9-1.10.8-0.91.2-1.01.31.3-1.10.0
Distance moved, locomotor task time 10.00.00.10.1-0.3-0.30.2-0.20.10.2-0.00.00.0-0.3-0.30.40.0
Vertical activity count, locomotor time 10.51.11.8-1.31.21.2-0.90.91.0-0.91.0-1.31.1-1.1-1.11.00.0
Time >=10cm from walls, locomotor time 20.40.61.10.9-0.8-0.80.7-0.7-0.70.6-0.70.8-0.90.70.7-1.00.0
Bouts of movement, locomotor time 22.33.74.4-1.91.91.9-2.02.02.1-2.12.1-1.92.0-2.0-2.01.90.0
Total resting periods, locomotor time 22.34.04.9-2.12.02.0-2.12.12.2-2.22.2-2.12.2-2.0-2.01.80.0
Rest time, locomotor task time 20.30.40.90.6-0.7-0.70.6-0.6-0.60.4-0.50.6-0.30.90.9-0.70.0
Distance moved, locomotor task time 20.00.00.10.2-0.4-0.40.2-0.2-0.20.2-0.20.1-0.2-0.1-0.1-0.20.0
Vertical activity count, locomotor time 20.20.30.5-0.70.70.7-0.40.40.4-0.40.4-0.60.4-0.6-0.60.30.0
Light reinforcement 10.71.62.51.6-1.6-1.61.2-1.2-1.21.3-1.21.4-1.11.31.3-0.51.0
Light reinforcement 20.00.10.40.0-0.0-0.0-0.10.10.2-0.00.2-0.10.3-0.4-0.4-0.3-0.6
Bone: marrow area5.612.314.5-3.43.43.4-3.83.83.7-3.63.7-3.43.3-3.6-3.62.9-3.4
Bone: maximum diameter1.42.53.0-1.61.61.6-1.71.71.6-1.61.6-1.71.6-1.6-1.61.3-1.7
Bone: maximum force13.123.225.3-4.74.74.7-5.05.05.0-4.94.9-4.64.7-5.0-5.04.4-4.8
Bone: maximum moment14.525.328.1-4.84.84.8-5.35.35.2-5.25.2-4.74.8-5.2-5.24.6-5.1
Mean time between licks in bursts0.20.51.61.3-1.3-1.30.4-0.4-0.30.2-0.41.1-0.60.40.40.10.3
Mean num. licks in bursts0.71.12.5-1.61.61.6-0.60.60.9-0.90.6-1.20.5-1.0-1.00.5-0.9
Cd content in liver0.20.30.50.7-0.7-0.70.4-0.4-0.50.5-0.40.4-0.50.60.60.00.7
Co content in liver0.20.31.0-0.20.20.20.6-0.6-0.60.6-0.6-0.2-0.30.40.4-1.00.6
Cu content in liver0.10.10.3-0.50.50.5-0.40.40.2-0.20.4-0.50.2-0.1-0.1-0.40.2
Fe content in liver1.92.33.41.8-1.8-1.81.5-1.5-1.41.4-1.41.6-1.51.31.3-1.21.4
K content in liver0.20.20.60.0-0.0-0.00.5-0.5-0.70.5-0.40.1-0.40.60.6-0.80.3
Mg content in liver0.20.20.40.3-0.3-0.30.3-0.3-0.60.5-0.30.4-0.40.50.5-0.60.2
Mn content in liver0.10.10.3-0.20.20.20.0-0.0-0.40.2-0.00.10.10.30.3-0.60.1
Na content in liver0.10.10.3-0.50.50.50.1-0.1-0.1-0.1-0.0-0.40.00.00.0-0.3-0.4
Rb content in liver1.41.62.30.9-0.9-0.91.3-1.3-1.51.5-1.40.7-1.41.41.4-1.21.5
Se content in liver3.64.24.92.0-2.0-2.02.1-2.1-2.22.1-2.12.1-2.12.22.2-1.62.0
Sr content in liver0.50.40.5-0.70.70.7-0.70.70.6-0.70.7-0.60.5-0.7-0.70.4-0.7
Zn content in liver0.91.01.41.2-1.2-1.20.8-0.8-1.11.0-0.81.0-1.11.11.1-0.70.9
Bone: minimum diameter7.113.014.6-3.33.33.3-3.83.83.8-3.73.8-3.43.5-3.7-3.73.5-3.8
Time in familiar zone, hab. session 10.10.10.2-0.50.50.5-0.10.10.2-0.10.1-0.40.3-0.2-0.20.4-0.3
Time in novel zone, hab. session 10.00.00.10.4-0.4-0.4-0.20.20.0-0.10.20.30.1-0.0-0.00.00.1
Total zone transitions, hab. session 10.00.00.20.1-0.1-0.10.2-0.2-0.20.2-0.20.00.20.20.2-0.40.1
Total locomotion distance, hab. session 10.30.40.50.7-0.7-0.70.6-0.6-0.70.7-0.60.7-0.60.70.7-0.50.6
Locomotion velocity, hab. session 10.20.20.30.6-0.6-0.60.5-0.5-0.60.5-0.50.6-0.40.50.5-0.30.4
Time in familiar zone, hab. session 22.02.12.9-1.71.71.7-1.31.31.3-1.41.3-1.61.3-1.3-1.31.6-1.4
Time in novel zone, hab. session 22.22.23.01.7-1.7-1.71.3-1.3-1.41.5-1.31.6-1.31.41.4-1.51.5
Total zone transitions, hab. session 20.30.40.60.8-0.8-0.80.5-0.5-0.50.5-0.50.7-0.50.50.5-0.80.4
Total locomotion distance, hab. session 20.60.81.41.2-1.2-1.20.7-0.7-0.80.7-0.71.2-0.80.70.7-0.70.6
Locomotion velocity, hab. session 20.40.51.11.0-1.0-1.00.5-0.5-0.60.5-0.51.0-0.70.50.5-0.50.4
Novel to familiar place preference ratio1.41.62.1-1.31.31.3-1.21.21.1-1.21.2-1.21.5-1.2-1.21.2-1.2
Novelty place preference0.91.01.4-1.11.11.1-1.01.00.8-0.91.0-1.01.2-0.9-0.91.1-0.9
Time in novel zone, NPP test0.60.71.1-0.90.90.9-0.80.80.7-0.70.8-0.81.0-0.7-0.70.9-0.8
Total zone transitions, NPP test3.04.35.62.2-2.2-2.22.0-2.0-2.02.0-2.02.3-1.82.02.0-2.41.9
Total locomotion distance, NPP test4.25.77.92.8-2.8-2.82.2-2.2-2.32.2-2.22.8-2.22.22.2-2.32.2
Locomotion velocity, NPP test2.84.05.92.4-2.4-2.41.8-1.8-1.91.8-1.82.4-1.91.81.8-1.91.8
Intraocular pressure4.97.08.22.4-2.4-2.42.7-2.7-2.72.7-2.72.5-2.92.82.8-2.72.5
Delta distance traveled before/after self-admin0.10.10.2-0.50.40.4-0.10.10.2-0.00.20.0-0.40.10.10.20.0
Delta ambulatory time before/after self-admin0.10.10.3-0.20.20.20.1-0.1-0.00.20.00.3-0.60.50.5-0.30.0
Parametrial fat weight0.40.81.41.0-1.0-1.01.0-1.0-1.01.1-1.00.8-1.20.80.8-0.60.0
Pavlov. Cond. lever latency0.40.51.31.1-1.1-1.10.4-0.4-0.40.4-0.41.0-0.80.30.3-0.50.4
Pavlov. Cond. magazine entry latency1.41.72.5-1.61.61.6-1.31.31.1-1.11.3-1.51.5-1.0-1.01.3-1.0
Pavlov. Cond. change in total contacts2.02.13.6-1.91.91.9-1.21.21.2-1.21.2-1.71.7-1.2-1.21.2-1.1
Pavlov. Cond. index score1.41.83.5-1.91.91.9-1.11.11.0-1.01.1-1.81.6-0.9-0.90.9-0.9
Pavlov. Cond. latency score1.31.63.3-1.81.81.8-1.01.00.9-0.91.0-1.71.4-0.8-0.80.8-0.9
Pavlov. Cond. lever contacts0.40.51.3-1.11.11.1-0.40.40.4-0.40.4-1.00.8-0.3-0.30.4-0.3
Pavlov. Cond. magazine entry number0.81.01.81.3-1.3-1.30.9-0.9-0.70.7-0.91.3-1.10.70.7-1.00.5
Pavlov. Cond. intertrial magazine entries4.95.86.42.3-2.3-2.32.5-2.5-2.52.4-2.52.3-2.52.42.4-2.12.4
Pavlov. Cond. lever-magazine prob. diff.1.82.23.9-2.02.02.0-1.31.31.2-1.21.3-1.91.7-1.1-1.11.2-1.1
Pavlov. Cond. response bias0.50.61.0-1.01.01.0-0.70.70.6-0.50.7-1.00.9-0.5-0.50.8-0.4
Pavlov. Cond. lever latency1.21.62.4-1.51.51.5-1.21.21.1-1.21.3-1.41.3-1.1-1.10.5-1.2
Pavlov. Cond. magazine entry latency0.50.61.71.3-1.3-1.30.5-0.5-0.40.5-0.51.1-0.80.40.40.40.5
Pavlov. Cond. change in total contacts0.40.71.2-0.90.90.9-0.80.80.7-0.70.8-1.01.0-0.8-0.81.1-0.7
Pavlov. Cond. index score0.50.71.51.2-1.2-1.20.7-0.7-0.70.7-0.71.0-0.80.60.60.10.7
Pavlov. Cond. latency score0.60.81.61.3-1.3-1.30.8-0.8-0.70.8-0.81.1-0.90.70.70.10.8
Pavlov. Cond. lever contacts1.01.32.21.5-1.5-1.51.1-1.1-1.01.0-1.11.3-1.21.01.0-0.41.0
Pavlov. Cond. magazine entry number0.10.10.3-0.60.60.6-0.10.10.1-0.20.2-0.40.3-0.0-0.0-0.5-0.1
Pavlov. Cond. intertrial magazine entries1.42.23.10.7-0.7-0.71.6-1.6-1.71.7-1.50.9-1.81.81.8-1.61.7
Pavlov. Cond. lever-magazine prob. diff.0.40.51.01.0-1.0-1.00.6-0.6-0.50.6-0.60.8-0.60.50.50.20.6
Pavlov. Cond. response bias0.50.71.41.2-1.2-1.20.7-0.7-0.70.7-0.71.0-0.90.60.60.20.7
Time in closed arm before self-admin1.11.42.1-1.21.21.2-1.11.11.2-1.01.2-1.11.5-1.4-1.41.10.0
Time in closed arm after self-admin0.20.30.7-0.60.60.6-0.50.50.4-0.30.4-0.60.8-0.4-0.40.50.0
Time in open arm before self-admin0.30.40.90.9-0.9-0.90.5-0.5-0.60.5-0.50.5-0.30.60.6-0.10.0
Time in open arm after self-admin0.20.20.40.6-0.5-0.50.6-0.6-0.40.3-0.50.6-0.60.60.6-0.40.0
Bone: periosteal estimation8.517.820.0-4.14.14.1-4.54.54.4-4.34.4-4.24.0-4.3-4.33.7-4.2
Bone: periosteal perimeter8.013.715.3-3.63.63.6-3.93.93.8-3.73.9-3.63.7-3.8-3.83.2-3.8
Bone: post-yield work5.78.410.0-2.52.52.5-3.23.23.0-3.13.1-2.52.7-3.1-3.12.7-3.1
Progressive ratio test 1 active lever presses6.27.610.53.2-3.2-3.22.9-2.9-3.03.0-2.93.0-3.12.42.4-1.70.0
Progressive ratio test 1 breakpoint6.07.310.03.2-3.1-3.12.9-2.9-2.92.9-2.83.0-3.12.32.3-1.60.0
Progressive ratio test 1 inactive lever presses0.50.71.81.4-1.3-1.30.7-0.7-0.60.7-0.60.7-0.70.30.3-0.70.0
Progressive ratio test 2 active lever presses1.51.73.31.8-1.8-1.81.3-1.3-1.31.3-1.21.3-1.40.80.8-1.00.0
Progressive ratio test 2 breakpoint1.31.53.01.7-1.7-1.71.2-1.2-1.21.3-1.11.2-1.30.70.7-0.90.0
Progressive ratio test 2 inactive lever presses0.50.92.21.5-1.4-1.40.7-0.7-0.60.8-0.60.9-1.00.70.7-0.90.0
Incentive Sensitization - Responses0.40.61.0-0.40.50.5-0.90.90.9-0.81.0-1.01.0-1.0-1.0-0.10.0
Incentive Sensitization - Breakpoint0.40.50.8-0.30.40.4-0.80.80.9-0.70.9-0.90.9-0.9-0.9-0.20.0
Sum of active levers in priming session hrs 5-60.10.10.30.2-0.3-0.30.2-0.2-0.20.3-0.30.3-0.20.60.6-0.50.0
Progressive ratio1.32.13.01.7-1.6-1.61.4-1.4-1.41.5-1.41.7-1.51.41.4-1.30.0
Food seeking constrained by brief footshock3.13.85.12.3-2.2-2.22.0-2.0-1.91.9-2.02.1-2.01.81.8-2.20.0
Seeking ratio, punishment vs. effort0.00.10.2-0.30.20.2-0.20.20.3-0.30.2-0.40.3-0.2-0.20.00.0
Retroperitoneal fat weight0.73.15.11.5-1.5-1.51.9-1.9-1.91.9-1.91.6-2.32.12.1-1.20.0
Reaction time number correct0.91.63.0-1.51.51.5-1.21.21.1-1.31.2-1.40.8-1.2-1.21.1-1.7
Reaction time mean minus median2.76.69.92.3-2.3-2.32.6-2.6-2.62.7-2.72.5-2.52.52.5-3.12.8
Reaction time mean minus median AUC1.84.57.81.7-1.7-1.72.1-2.1-2.22.3-2.31.9-2.02.12.1-2.82.3
Reaction time num false alarms1.31.92.41.5-1.5-1.51.2-1.2-1.31.3-1.21.3-1.21.51.5-1.21.3
Reaction time num false alarms AUC1.42.22.71.7-1.7-1.71.3-1.3-1.51.4-1.31.4-1.21.61.6-1.21.5
Reaction time trials correct on left0.91.63.0-1.51.51.5-1.21.21.1-1.31.2-1.40.8-1.2-1.21.1-1.7
Reaction time trials on left0.71.32.5-1.41.41.4-1.01.00.9-1.11.1-1.20.6-1.0-1.00.9-1.6
Reaction time mean0.60.91.10.9-0.9-0.90.9-0.9-0.91.0-0.91.0-1.01.01.0-0.81.0
Reaction time mean AUC0.30.50.70.6-0.6-0.60.7-0.7-0.70.7-0.70.7-0.80.80.8-0.70.8
Median of all reaction times0.00.00.10.2-0.2-0.20.1-0.1-0.00.1-0.10.1-0.20.30.30.30.2
Reaction time omissions7.611.112.33.2-3.2-3.23.4-3.4-3.33.3-3.33.2-3.33.43.4-3.53.3
Reaction time false alarm rate1.82.53.51.9-1.9-1.91.4-1.4-1.41.5-1.41.6-1.11.71.7-1.31.8
Reaction time premature initiation rate3.24.46.21.8-1.8-1.82.1-2.1-2.12.0-2.22.1-2.22.42.4-1.82.5
Reaction time premature initiations1.01.72.70.9-0.9-0.91.4-1.4-1.41.1-1.41.2-1.61.61.6-1.11.5
Std. dev. reaction times3.56.48.82.3-2.3-2.32.5-2.5-2.62.6-2.62.4-2.42.62.6-3.02.7
Reaction time trials completed0.71.32.5-1.41.41.4-1.01.00.9-1.11.1-1.20.6-1.0-1.00.9-1.6
Reaction time trials AUC1.22.23.8-1.71.71.7-1.41.41.2-1.51.4-1.61.0-1.4-1.41.3-2.0
Run reversals in cocaine runway, females0.40.40.8-0.80.60.6-0.70.70.9-0.80.7-0.40.4-0.8-0.80.20.0
Run reversals in cocaine runway, males0.40.41.10.6-0.6-0.60.7-0.7-0.70.6-0.70.5-0.40.50.5-1.10.0
Latency to leave start box in cocaine runway0.00.00.40.0-0.1-0.1-0.10.1-0.10.20.3-0.10.20.10.10.60.0
Latency to leave start box in cocaine runway, F0.70.81.31.1-1.1-1.11.0-1.0-1.11.1-0.80.9-0.80.80.8-0.60.0
Latency to leave start box in cocaine runway, M1.91.83.5-1.61.61.6-1.41.41.3-1.11.4-1.21.4-1.0-1.01.90.0
Std. dev. time between licks in bursts1.52.03.01.7-1.7-1.71.2-1.2-1.21.3-1.21.7-1.31.31.3-1.41.2
Total sessions with >9 infusions1.92.44.22.0-2.1-2.11.6-1.6-1.61.7-1.51.7-1.70.90.9-0.50.0
Short access day 1 total inactive lever presses1.41.83.31.8-1.8-1.81.4-1.4-1.41.3-1.31.4-1.50.80.8-0.60.0
Short access day 10 total inactive lever presses0.00.10.2-0.10.20.2-0.30.30.4-0.30.3-0.30.3-0.0-0.00.30.0
Short access day 1 total infusions1.11.52.71.6-1.7-1.71.3-1.3-1.31.4-1.11.2-1.50.60.6-0.30.0
Short access day 10 total infusions1.52.03.51.8-1.9-1.91.4-1.4-1.41.5-1.41.8-1.60.60.6-0.70.0
Short access total infusions2.93.75.72.4-2.4-2.42.1-2.1-2.02.2-2.02.1-2.31.21.2-1.10.0
Short access day 1 locomotion0.40.61.31.1-1.0-1.00.7-0.7-0.70.7-0.60.7-0.8-0.6-0.60.20.0
Short access day 10 total locomotion0.20.41.01.0-0.8-0.80.7-0.7-0.80.6-0.60.8-0.90.00.0-0.40.0
Short access total locomotion0.81.02.01.4-1.3-1.31.0-1.0-1.11.0-1.01.3-1.30.10.10.00.0
One hour access (0.3 mA shock)0.30.40.9-0.60.50.5-0.60.60.6-0.50.6-0.80.6-0.8-0.80.90.0
Compulsive drug intake0.30.40.9-0.50.40.4-0.60.60.6-0.60.6-1.00.8-0.7-0.70.10.0
One hour access (shock baseline)0.20.31.2-0.50.50.5-0.50.50.5-0.50.5-0.50.4-0.6-0.61.10.0
Social response proportion0.20.20.80.1-0.1-0.10.4-0.4-0.30.4-0.30.2-0.60.40.4-0.70.9
Social responses4.45.69.82.0-2.0-2.02.2-2.2-2.42.4-2.32.2-2.12.82.8-2.33.1
Social time0.20.30.7-0.50.50.5-0.70.70.7-0.80.8-0.40.3-0.2-0.20.2-0.2
Soleus weight0.92.53.5-1.51.51.5-1.61.61.6-1.81.5-1.51.5-1.7-1.71.3-1.9
Bone: stiffness17.528.531.6-5.05.05.0-5.65.65.5-5.55.6-5.05.3-5.6-5.64.8-5.5
Tibialis anterior weight3.512.018.1-4.04.04.0-3.13.13.2-3.23.0-4.04.3-3.1-3.12.9-2.8
Time to tail flick, vehicle, before self-admin1.71.84.31.3-1.4-1.41.1-1.1-1.11.0-1.21.0-1.12.12.1-1.50.0
Time to tail flick, vehicle, after self-admin0.30.41.1-0.60.60.6-0.50.50.5-0.60.4-0.60.7-0.7-0.71.00.0
Time to tail flick, test, before self-admin0.30.30.70.3-0.1-0.10.7-0.7-0.40.5-0.40.5-0.30.80.8-0.80.0
Time to tail flick, test, after self-admin0.80.81.7-0.50.60.6-1.01.01.1-1.31.0-0.71.0-1.0-1.01.20.0
Delta time to tail flick, vehicle, before/after SA0.90.81.9-0.90.90.9-0.70.70.7-0.70.7-0.90.7-1.4-1.41.40.0
Delta time to tail flick, test, before/after SA0.60.61.6-0.30.30.3-0.90.90.8-1.00.7-0.60.7-1.0-1.01.20.0
Tibia length3.910.914.4-3.23.23.2-3.43.43.4-3.43.4-3.12.9-3.2-3.23.8-3.2
Ambulatory time before self-admin1.82.73.61.5-1.6-1.61.9-1.9-1.81.8-1.91.7-1.81.41.4-1.80.0
Ambulatory time after self-admin1.71.93.41.0-1.1-1.11.6-1.6-1.31.4-1.41.6-1.81.51.5-1.60.0
Bone: tissue strength1.61.61.9-1.41.41.4-1.31.31.3-1.21.2-1.41.3-1.3-1.31.2-1.0
Total heroin consumption0.50.61.4-1.21.01.0-0.60.60.6-0.60.7-0.90.6-0.6-0.60.90.0
Bone: trabecular number3.25.26.4-2.42.42.4-2.32.32.4-2.32.3-2.02.0-2.4-2.41.5-2.5
Bone: trabecular spacing0.81.01.51.0-1.0-1.01.0-1.0-1.21.1-1.10.8-0.81.21.2-0.31.2
Bone: trabecular thickness0.50.60.8-0.90.90.9-0.70.70.7-0.80.7-0.80.8-0.8-0.8-0.1-0.9
Bone: trabecular tissue density0.81.22.3-0.40.40.4-1.21.21.2-1.21.2-0.41.5-1.3-1.31.3-1.1
Water consumed over 24 hours0.00.00.1-0.30.30.3-0.10.10.00.10.1-0.2-0.2-0.1-0.1-0.10.0
Number of responses in last shaping day0.10.10.60.2-0.1-0.1-0.20.20.2-0.20.20.10.1-0.8-0.80.70.0