Hub : Genes

Aspscr1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr10_105970208_105982422 0.04 0.03 5.9e-05 0.03 0.04 0.02 0.02 2.2e-04 3.5e-05 9.2e-04 1.3e-03
2 PL intron excision ratio chr10_105976957_105982422 0.04 0.03 1.3e-05 0.04 0.04 0.03 0.03 3.2e-05 8.8e-06 2.6e-04 2.1e-04
3 Liver alternative TSS NM_001398979.1 0.05 0.04 1.4e-03 0.01 0.02 0.03 0.02 1.1e-02 1.1e-03 5.5e-04 2.1e-03
4 NAcc gene expression Aspscr1 0.07 0.05 2.7e-08 0.05 0.07 0.07 0.07 2.0e-06 7.4e-09 4.0e-08 4.3e-08
5 PL gene expression Aspscr1 0.11 0.07 1.2e-11 0.08 0.1 0.1 0.1 2.7e-09 2.0e-11 1.2e-10 1.1e-10
6 BLA gene expression Aspscr1 0.06 0.05 6.7e-03 0.06 0.03 0.04 0.04 6.8e-04 1.2e-02 4.1e-03 3.1e-03
7 Brain gene expression Aspscr1 0.05 0.04 7.5e-04 0.02 0.03 0.02 0.02 1.1e-02 2.2e-03 5.7e-03 4.1e-03
8 RMTg intron excision ratio chr10_105989464_105989536 0.23 0.21 2.8e-03 0.07 0.09 0.08 0.09 5.7e-03 2.0e-03 3.4e-03 2.7e-03
9 Liver gene expression Aspscr1 0.16 0.08 5.5e-14 0.1 0.11 0.11 0.11 8.3e-11 8.0e-12 2.8e-12 6.0e-12
10 Liver alternative TSS XM_039087550.1 0.04 0.04 3.7e-03 0.04 0.02 0.04 0.04 2.1e-05 9.3e-04 2.9e-05 2.6e-05
11 Liver intron excision ratio chr10_105976957_105982422 0.1 0.07 3.7e-06 0.04 0.04 0.05 0.04 1.0e-05 1.1e-05 6.5e-06 1.4e-05
12 Liver intron excision ratio chr10_105970208_105982422 0.09 0.06 8.2e-06 0.02 0.04 0.04 0.04 3.2e-03 2.0e-05 1.5e-05 3.6e-05
13 Liver mRNA stability Aspscr1 0.17 0.1 1.9e-03 -0 0.01 0.02 0 4.1e-01 1.2e-02 3.9e-03 3.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.20.41.1-0.50.60.80.00.00.4-0.3-0.2-0.8-0.8-0.80.81.0
Area under the delay curve0.70.82.01.4-1.4-1.0-1.1-1.10.8-0.8-0.8-0.10.40.0-0.0-0.9
BMI with tail0.30.92.4-1.51.61.40.60.70.30.00.1-0.9-1.0-0.70.71.1
BMI without tail4.08.319.6-4.04.24.41.61.90.4-0.20.5-3.2-4.0-2.92.82.6
Body weight1.87.619.3-4.44.43.63.23.3-2.32.02.2-0.6-2.0-0.50.42.8
Weight adjusted by age1.31.42.9-1.71.71.11.51.6-1.41.31.20.5-0.10.4-0.41.0
Bone surface0.20.30.5-0.70.70.70.50.5-0.70.30.3-0.2-0.5-0.20.20.7
Bone volume0.20.30.6-0.70.70.80.40.4-0.30.10.2-0.5-0.7-0.50.50.7
Breakpoint value in progressive ratio session1.11.22.4-0.50.4-0.51.11.1-0.71.41.21.41.11.5-1.6-0.8
Number of licking bursts0.40.51.2-0.40.40.8-0.2-0.20.0-0.5-0.5-0.9-0.9-1.11.10.8
Context. condit. distance diff. score1.82.14.9-0.91.02.0-0.5-0.40.7-1.2-1.0-2.2-2.2-2.02.00.9
Locomotion velocity, session 11.92.15.21.8-1.9-2.3-0.5-0.6-0.10.40.21.52.01.5-1.5-2.0
Locomotion distance, session 12.02.65.01.8-1.7-0.5-2.2-2.21.9-2.1-2.0-1.3-0.5-1.31.3-0.1
Locomotion velocity, session 22.32.76.82.6-2.6-2.2-1.8-1.90.2-1.1-1.30.71.30.8-0.8-1.8
Locomotion distance, session 20.71.02.00.6-0.50.4-1.2-1.20.8-1.4-1.2-1.3-1.1-1.21.20.4
Locomotion velocity, session 31.11.33.21.7-1.8-1.8-0.9-1.00.3-0.2-0.51.11.50.9-0.9-0.9
Locomotion distance, session 31.61.74.52.1-2.1-1.6-1.7-1.70.8-1.1-1.30.30.90.3-0.3-1.0
Stereotopy head waving bouts, day 30.40.51.30.9-1.0-1.2-0.3-0.4-0.00.1-0.00.91.00.8-0.7-0.3
Stereotopy head waving duration, day 30.20.20.50.7-0.7-0.7-0.4-0.40.1-0.2-0.20.40.50.3-0.30.1
Locomotion velocity, session 70.40.51.11.0-1.0-0.5-1.0-1.00.5-0.8-0.9-0.30.1-0.20.2-0.2
Locomotion distance, session 72.53.26.11.9-1.7-0.4-2.5-2.42.2-2.4-2.4-1.5-0.7-1.41.5-0.5
Stereotopy head waving bouts, day 70.10.10.9-0.40.40.40.30.3-0.50.20.1-0.1-0.3-0.00.00.9
Stereotopy head waving duration, day 70.30.41.5-0.60.60.50.60.6-1.20.50.40.3-0.10.3-0.31.0
Locomotion velocity, session 81.01.22.50.5-0.40.5-1.3-1.20.9-1.6-1.4-1.4-1.2-1.31.3-0.1
Locomotion distance, session 83.34.910.4-0.50.72.4-1.4-1.31.4-2.4-2.1-3.2-3.1-3.13.11.6
Degree of sensitization distance0.70.71.7-0.91.01.30.10.20.4-0.4-0.2-1.3-1.3-1.11.10.2
Degree of sensitization stereotypy0.30.31.1-0.70.80.80.40.5-0.70.20.2-0.3-0.6-0.20.21.1
Conditioned locomotion2.73.27.2-2.62.72.71.41.5-0.30.40.7-1.6-2.1-1.51.42.1
Cocaine response after cond. corrected0.20.30.80.2-0.3-0.60.30.30.30.60.60.50.60.5-0.5-0.9
Cocaine response after cond. not corrected0.30.41.20.7-0.8-0.9-0.2-0.30.40.10.10.50.70.4-0.4-1.1
Cocaine response before conditioning0.60.71.71.0-1.0-0.4-1.3-1.30.2-1.2-1.3-0.4-0.1-0.30.40.1
Saline control response1.62.15.0-2.22.21.81.71.7-1.41.01.2-0.3-1.1-0.20.21.5
Bone: connectivity density0.50.81.6-0.00.10.8-0.7-0.60.4-1.0-0.9-1.2-1.2-1.21.20.8
Bone: cortical apparent density1.41.84.42.1-2.1-1.9-1.4-1.51.6-0.7-1.00.61.30.3-0.3-0.8
Bone: cortical area3.24.910.5-3.23.22.22.92.9-2.52.22.40.4-0.80.2-0.31.9
Bone: cortical porosity3.53.87.3-0.60.4-1.22.01.9-1.72.52.42.72.22.4-2.4-0.8
Bone: cortical porosity2.62.85.2-0.90.7-0.71.91.8-1.62.32.22.21.62.0-2.0-0.5
Bone: cortical thickness3.25.210.2-3.02.81.43.23.1-2.72.72.91.30.11.0-1.11.3
Bone: cortical thickness1.01.12.4-1.51.40.71.51.5-0.81.31.40.50.00.3-0.40.9
Bone: cortical tissue density1.62.15.22.2-2.3-2.0-1.5-1.61.7-0.8-1.00.71.40.4-0.3-0.9
Condit. Reinf. active minus inactive responses1.21.33.5-1.81.91.61.31.4-0.80.70.9-0.5-1.1-0.50.40.4
Condit. Reinf. active-inactive response ratio0.50.51.3-1.11.11.00.80.8-0.10.50.6-0.3-0.6-0.40.30.6
Condit. Reinf. active responses2.32.86.9-2.62.62.41.81.9-1.10.91.2-0.9-1.7-0.80.81.0
Condit. Reinf. inactive responses0.70.81.9-1.41.41.30.91.0-0.80.50.7-0.6-1.0-0.40.40.3
Incentive salience index mean1.01.22.9-1.71.71.71.01.1-0.90.40.6-0.7-1.3-0.70.60.7
Condit. Reinf. lever presses0.30.40.8-0.10.10.7-0.5-0.5-0.1-0.8-0.7-0.8-0.9-0.80.80.6
Condit. Reinf. active minus inactive responses0.50.61.6-1.21.31.00.91.0-0.70.40.7-0.4-0.7-0.20.2-0.1
Condit. Reinf. active-inactive response ratio1.51.63.2-1.71.70.91.81.8-1.51.41.60.4-0.30.4-0.5-0.2
Condit. Reinf. active responses0.20.30.5-0.70.70.70.30.40.3-0.00.2-0.7-0.7-0.50.5-0.4
Condit. Reinf. inactive responses0.40.52.10.7-0.7-0.3-0.9-0.81.4-0.8-0.8-0.6-0.1-0.50.5-0.5
Condit. Reinf. lever presses0.40.61.4-0.60.60.9-0.00.01.2-0.4-0.2-1.0-0.9-1.01.00.4
Condit. Reinf. lever reinforcers received0.30.40.9-0.70.80.90.20.30.8-0.2-0.0-1.0-0.9-0.80.8-0.1
Conditioned reinforcement - actives0.60.61.5-0.10.10.8-0.5-0.5-0.3-0.8-0.8-0.9-0.8-1.21.21.1
Conditioned reinforcement - inactives0.91.01.8-1.31.31.11.31.3-1.31.01.10.1-0.5-0.10.0-0.6
Conditioned locomotion0.10.20.5-0.20.20.7-0.1-0.1-0.4-0.2-0.3-0.3-0.4-0.70.7-0.1
Patch foraging indifference point 0 sec0.10.21.1-0.30.30.40.30.3-0.10.20.2-0.1-0.3-0.20.21.1
Patch foraging indifference point AUC0.20.20.5-0.10.10.3-0.00.00.7-0.20.0-0.6-0.5-0.60.6-0.4
Delay disc. indifference point, 0s delay0.00.00.20.3-0.3-0.1-0.3-0.3-0.2-0.2-0.30.00.20.1-0.10.4
Delay disc. indifference point, 16s delay2.12.14.51.4-1.3-0.1-1.9-1.92.1-1.9-1.8-1.2-0.5-1.31.30.4
Delay disc. indifference point, 2s delay0.30.31.20.7-0.7-0.6-0.4-0.4-0.8-0.1-0.10.40.40.4-0.4-1.1
Delay disc. indifference point, 24s delay2.72.76.62.5-2.6-2.2-1.6-1.60.7-0.7-0.90.91.50.8-0.7-2.3
Delay disc. indifference point, 4s delay0.20.20.70.7-0.7-0.8-0.4-0.40.2-0.2-0.10.20.40.2-0.2-0.3
Delay disc. indifference point, 8s delay0.60.61.91.0-1.0-1.2-0.3-0.3-0.20.20.10.60.80.7-0.7-1.4
Indifference point function ln k0.50.71.41.2-1.2-0.8-1.1-1.20.9-0.9-1.00.10.4-0.00.10.3
Indifference point function log k0.50.71.41.2-1.2-0.8-1.1-1.20.9-0.9-1.00.10.4-0.00.10.3
Patch foraging total patch changes 0 sec0.10.21.1-0.30.30.50.20.20.20.10.1-0.3-0.5-0.40.41.0
Patch foraging total patch changes 12 sec0.10.10.3-0.20.10.00.40.40.10.40.6-0.0-0.1-0.10.0-0.6
Patch foraging total patch changes 18 sec0.60.82.70.1-0.10.5-0.6-0.61.7-0.8-0.7-1.1-0.8-1.21.20.9
Patch foraging total patch changes 24 sec0.30.41.5-0.90.90.90.60.6-0.00.30.3-0.4-0.5-0.50.51.2
Patch foraging total patch changes 6 sec0.30.40.9-0.70.70.50.90.9-0.80.80.90.2-0.30.1-0.10.6
Patch foraging time to switch 0 sec0.20.30.90.9-0.9-0.8-0.6-0.70.1-0.4-0.50.40.60.2-0.2-0.5
Patch foraging water rate 0 sec1.11.84.7-2.12.22.01.31.4-0.20.60.8-1.0-1.5-0.70.70.9
Patch foraging water rate 12 sec0.30.51.1-0.60.70.9-0.2-0.10.7-0.6-0.5-0.9-0.9-0.70.71.1
Patch foraging water rate 18 sec0.81.02.7-0.91.01.5-0.1-0.00.2-0.7-0.6-1.2-1.3-1.11.11.6
Patch foraging water rate 24 sec1.72.46.1-1.81.92.30.30.51.1-0.5-0.3-1.8-1.8-1.61.52.5
Patch foraging water rate 6 sec0.20.20.5-0.30.40.7-0.2-0.20.1-0.5-0.5-0.7-0.7-0.50.5-0.2
Seeking ratio, delayed vs. immediate footshock1.01.12.4-1.51.51.31.11.1-1.30.60.7-0.5-1.0-0.60.61.3
Distance traveled before self-admin1.61.73.2-1.11.0-0.01.61.6-1.81.81.51.30.81.4-1.4-0.5
Distance traveled after self-admin0.40.41.0-0.90.91.00.30.40.0-0.10.0-0.7-0.8-0.70.60.6
Extensor digitorum longus weight0.62.44.6-0.50.61.7-0.8-0.71.5-1.5-1.3-2.1-2.1-2.12.11.7
Bone: elastic displacement0.80.92.0-1.21.20.51.41.4-0.61.21.30.60.10.4-0.41.0
Bone: elastic work5.26.814.2-3.12.91.03.83.7-2.53.53.61.80.71.7-1.80.7
Bone: endosteal estimation0.41.02.1-0.20.20.9-0.7-0.61.0-1.0-0.9-1.4-1.2-1.41.40.8
Bone: endosteal perimeter0.30.71.5-1.21.21.01.01.0-1.10.70.7-0.1-0.6-0.10.10.9
Epididymis fat weight0.51.33.0-1.71.71.70.70.8-0.10.10.1-0.8-1.2-0.90.81.7
Delta time in closed arm before/after self-admin0.30.30.70.2-0.10.4-0.5-0.5-0.4-0.7-0.6-0.6-0.4-0.70.70.9
Delta time in open arm before/after self-admin0.10.10.40.00.00.2-0.3-0.20.6-0.2-0.5-0.10.00.1-0.10.5
Diff in mean of infusions in LGA sessions0.50.61.80.7-0.7-1.1-0.3-0.4-0.20.1-0.31.01.31.0-1.00.5
Delay discount exponential model param1.01.12.8-1.71.71.41.11.2-0.80.70.7-0.2-0.7-0.30.31.2
Extinction: sum of active levers before priming1.71.73.31.5-1.6-1.8-0.9-0.90.5-0.1-0.61.41.81.6-1.6-1.0
Active lever presses in extinction session 61.71.73.80.7-0.8-1.30.20.1-0.80.90.51.91.71.9-1.9-1.9
Bone: final force2.84.610.8-3.33.22.32.82.8-2.12.02.30.0-1.00.1-0.11.4
Bone: final moment3.45.412.2-3.53.42.43.23.2-2.22.42.60.3-0.90.3-0.31.6
Food consumed during 24 hour testing period0.20.30.6-0.70.80.70.50.5-0.60.30.30.0-0.40.4-0.4-0.6
Glucose5.07.517.22.3-2.5-4.00.20.10.11.71.23.64.13.5-3.5-3.5
Heart weight0.20.30.7-0.80.80.40.80.8-0.00.60.60.0-0.10.1-0.10.2
Delay discount hyperbolic model param1.01.02.7-1.61.71.41.11.2-0.60.70.7-0.2-0.7-0.30.31.2
Intermittent access intake day 1-15 change0.60.61.3-1.11.00.71.11.1-0.60.91.10.0-0.4-0.0-0.0-0.3
Intermittent access intake escalation0.50.51.0-1.01.00.90.90.9-0.60.60.8-0.2-0.7-0.30.3-0.2
Intermittent access intake escalation 22.02.04.7-1.41.30.41.91.9-2.21.81.81.00.31.0-1.0-0.1
Intermitt. access day 1 inactive lever presses1.01.11.8-1.11.10.61.31.3-1.01.21.30.6-0.00.9-0.9-1.2
Intermitt. access day 15 inactive lever presses0.70.82.3-1.21.21.50.50.5-0.90.00.1-0.7-1.0-0.60.61.0
Intermitt. access escalation Index1.31.12.8-0.91.01.7-0.00.0-0.3-0.6-0.5-1.4-1.5-1.31.31.4
Intermittent access day 1 total infusions0.30.40.8-0.80.80.90.50.5-0.00.20.3-0.6-0.9-0.80.70.1
Intermittent access day 15 total infusions0.60.71.7-1.11.11.30.70.7-0.30.20.4-0.7-1.1-0.90.90.1
Intermittent access terminal intake (last 3 days)0.80.91.8-1.31.31.31.11.1-0.70.70.8-0.4-0.9-0.70.70.3
Intermittent access total infusions0.50.61.4-1.01.01.20.60.6-0.40.20.4-0.7-1.1-0.90.8-0.0
Intermittent access day 1 locomotion0.40.41.3-0.70.71.10.20.2-0.1-0.2-0.1-0.7-0.9-0.90.80.3
Intermittent access day 15 total locomotion0.40.40.6-0.80.80.80.80.8-0.60.60.7-0.2-0.6-0.40.3-0.6
Intermittent access total locomotion0.30.41.1-0.80.81.10.60.6-0.50.30.4-0.4-0.8-0.50.5-0.5
Intermittent access standard deviation1.71.83.60.6-0.7-1.50.50.4-1.21.20.91.81.71.9-1.9-1.6
Left kidney weight0.10.31.8-0.20.1-0.10.50.5-1.40.70.60.60.40.5-0.5-0.2
Right kidney weight0.00.00.30.1-0.1-0.0-0.1-0.1-0.6-0.0-0.10.10.0-0.10.10.1
Cocaine induced anxiety5.05.810.2-2.12.00.33.03.0-3.03.22.92.31.22.4-2.5-1.3
Post-drug Anxiety1.51.63.3-0.60.5-0.31.41.4-1.41.61.51.40.91.4-1.4-1.8
Baseline Anxiety4.54.89.42.9-2.8-1.4-3.0-3.12.4-2.6-2.6-1.10.1-1.41.4-0.7
Tail length3.310.023.6-4.74.84.92.93.0-1.71.11.8-2.3-3.8-2.22.12.6
Length with tail1.45.010.3-3.23.22.42.92.9-2.92.22.30.3-1.00.3-0.41.6
Length without tail1.63.68.50.9-1.0-2.10.70.6-2.01.71.22.92.82.7-2.7-0.8
Times rat made contact with spout1.92.23.8-1.10.9-0.11.81.7-1.91.91.91.50.71.7-1.7-1.2
Lifetime Intake0.20.30.7-0.50.50.80.30.3-0.40.00.1-0.5-0.8-0.70.7-0.3
Liver weight, left0.81.32.80.4-0.5-1.30.50.5-0.61.10.81.71.71.7-1.6-0.5
Liver weight, right1.01.76.4-1.81.81.41.51.5-2.51.11.10.2-0.50.4-0.5-0.0
Locomotor activity0.40.61.31.2-1.2-1.0-0.9-0.90.7-0.5-0.70.40.80.2-0.2-0.3
Locomotor testing distance0.71.22.31.4-1.3-0.7-1.5-1.51.4-1.2-1.4-0.10.5-0.40.50.2
Locomotor testing rearing0.30.51.10.8-0.7-0.2-1.0-1.01.0-0.9-1.0-0.30.1-0.40.40.1
Locomotion in novel chamber0.30.41.30.5-0.5-0.0-0.8-0.71.2-0.7-0.9-0.5-0.0-0.40.40.3
Locomotion in novel chamber post-restriction1.41.74.0-2.02.01.41.71.7-1.21.11.5-0.5-1.1-0.40.30.2
Fecal boli incidents, locomotor time 10.40.51.00.8-0.8-0.2-1.0-1.00.9-0.9-0.9-0.4-0.1-0.40.4-0.4
Change in fecal boli incidents, locomotor task1.71.65.01.4-1.5-2.2-0.1-0.2-0.10.60.51.61.91.3-1.2-1.2
Time >=10cm from walls, locomotor time 11.61.73.5-0.91.01.5-0.10.00.7-0.7-0.5-1.8-1.9-1.81.81.8
Bouts of movement, locomotor time 11.01.12.51.6-1.6-1.5-1.1-1.20.7-0.6-0.80.40.90.4-0.4-1.2
Total resting periods, locomotor time 11.31.43.31.7-1.7-1.8-1.0-1.10.5-0.5-0.60.71.20.7-0.7-1.7
Rest time, locomotor task time 10.50.62.90.5-0.6-0.90.1-0.0-0.60.40.40.90.90.8-0.8-1.7
Distance moved, locomotor task time 10.60.63.0-0.80.90.90.30.30.9-0.0-0.1-0.6-0.7-0.60.61.7
Vertical activity count, locomotor time 11.11.14.6-1.11.21.50.10.20.8-0.4-0.5-1.0-1.2-0.90.92.1
Time >=10cm from walls, locomotor time 20.30.30.6-0.20.20.5-0.00.0-0.4-0.2-0.1-0.7-0.8-0.80.80.8
Bouts of movement, locomotor time 20.60.71.31.2-1.1-0.8-1.1-1.10.7-1.0-0.9-0.20.30.1-0.1-0.5
Total resting periods, locomotor time 20.60.61.40.9-0.9-0.4-1.2-1.10.6-1.2-1.1-0.6-0.1-0.30.3-0.0
Rest time, locomotor task time 20.10.10.20.2-0.3-0.5-0.2-0.2-0.2-0.1-0.10.20.30.4-0.3-0.4
Distance moved, locomotor task time 20.20.21.4-0.10.10.3-0.0-0.00.7-0.1-0.1-0.2-0.1-0.30.31.2
Vertical activity count, locomotor time 20.80.93.2-0.30.40.9-0.5-0.41.1-0.8-0.8-1.1-0.9-1.01.01.8
Light reinforcement 11.01.86.1-1.51.61.90.20.30.2-0.5-0.6-1.4-1.6-1.41.42.5
Light reinforcement 21.11.54.6-1.81.91.80.81.0-1.00.20.2-0.6-1.1-0.60.62.1
Bone: marrow area0.40.92.0-0.10.20.9-0.7-0.61.1-1.0-0.9-1.4-1.2-1.31.30.8
Bone: maximum diameter0.81.53.2-1.71.71.41.41.4-1.80.91.00.1-0.70.0-0.01.5
Bone: maximum force2.84.812.0-3.53.42.52.82.9-1.91.92.2-0.2-1.3-0.10.11.3
Bone: maximum moment3.25.613.4-3.73.62.53.23.2-2.12.32.60.0-1.10.1-0.21.4
Mean time between licks in bursts0.91.22.51.6-1.5-0.9-1.5-1.61.2-1.2-1.3-0.40.2-0.50.5-0.4
Mean num. licks in bursts1.21.43.1-0.40.3-0.61.21.1-1.01.41.41.41.01.7-1.8-1.3
Cd content in liver1.11.22.71.5-1.4-0.9-1.4-1.41.6-1.1-1.2-0.10.30.0-0.0-0.9
Co content in liver0.10.10.30.5-0.4-0.0-0.5-0.60.6-0.4-0.5-0.2-0.20.0-0.00.0
Cu content in liver1.41.73.4-0.30.2-0.61.21.0-1.51.41.41.51.11.8-1.8-1.3
Fe content in liver0.70.81.51.2-1.2-0.8-1.2-1.21.2-1.0-1.1-0.10.3-0.20.30.4
K content in liver1.61.64.5-1.61.62.10.60.6-0.9-0.20.1-1.3-1.9-1.31.21.2
Mg content in liver2.12.24.6-0.50.61.7-0.8-0.70.4-1.5-1.2-2.1-2.1-2.22.11.1
Mn content in liver0.20.31.5-0.60.60.40.60.6-1.20.40.50.1-0.10.1-0.20.1
Na content in liver0.00.00.40.0-0.1-0.0-0.0-0.0-0.70.0-0.10.10.10.2-0.2-0.1
Rb content in liver1.01.32.8-1.31.31.70.40.50.0-0.3-0.0-1.4-1.6-1.41.31.2
Se content in liver0.30.30.7-0.70.70.70.40.4-0.30.10.2-0.4-0.6-0.70.60.8
Sr content in liver1.71.53.70.4-0.6-1.50.80.7-0.91.41.21.91.91.5-1.5-0.2
Zn content in liver0.10.10.90.1-0.2-0.1-0.0-0.1-0.9-0.00.10.2-0.00.1-0.1-0.8
Bone: minimum diameter1.73.16.5-2.52.51.92.32.2-2.21.71.80.3-0.80.2-0.21.7
Time in familiar zone, hab. session 10.20.20.50.1-0.1-0.60.40.40.40.50.60.60.70.4-0.4-0.7
Time in novel zone, hab. session 10.10.10.2-0.00.10.4-0.3-0.2-0.3-0.4-0.4-0.4-0.5-0.20.20.2
Total zone transitions, hab. session 10.30.40.90.6-0.6-0.2-0.8-0.80.9-0.8-0.8-0.5-0.2-0.40.4-0.2
Total locomotion distance, hab. session 10.40.51.2-0.30.30.9-0.4-0.40.4-0.7-0.7-0.9-1.0-0.90.91.1
Locomotion velocity, hab. session 10.40.61.7-0.30.40.9-0.4-0.40.4-0.7-0.7-0.9-1.0-1.01.01.3
Time in familiar zone, hab. session 20.30.31.00.5-0.4-0.1-0.6-0.61.0-0.6-0.6-0.5-0.2-0.50.5-0.1
Time in novel zone, hab. session 20.00.00.00.2-0.2-0.2-0.1-0.1-0.2-0.1-0.10.10.10.2-0.1-0.2
Total zone transitions, hab. session 21.72.14.30.2-0.11.1-1.4-1.31.4-1.8-1.6-2.1-1.8-1.91.90.6
Total locomotion distance, hab. session 22.02.65.6-0.80.92.0-0.7-0.60.6-1.5-1.3-2.3-2.4-2.22.11.7
Locomotion velocity, hab. session 21.92.65.8-1.01.22.2-0.4-0.30.3-1.3-1.0-2.2-2.4-2.12.11.8
Novel to familiar place preference ratio2.42.54.9-1.71.60.42.22.2-1.72.12.11.20.51.2-1.30.1
Novelty place preference2.52.54.8-1.61.50.32.22.2-1.82.12.21.30.61.3-1.4-0.1
Time in novel zone, NPP test1.91.93.7-1.51.40.41.91.9-1.51.81.91.10.51.1-1.1-0.1
Total zone transitions, NPP test2.53.66.50.5-0.31.2-1.9-1.81.8-2.4-2.2-2.6-2.1-2.42.41.0
Total locomotion distance, NPP test2.83.97.9-0.30.52.0-1.4-1.31.3-2.1-1.9-2.8-2.6-2.72.62.0
Locomotion velocity, NPP test2.02.95.8-0.50.71.9-0.9-0.81.0-1.6-1.5-2.4-2.3-2.32.32.0
Intraocular pressure0.50.61.4-1.11.21.10.70.70.10.10.5-0.8-1.0-0.80.80.6
Delta distance traveled before/after self-admin1.21.32.50.5-0.40.4-1.2-1.21.6-1.5-1.4-1.3-0.9-1.41.41.0
Delta ambulatory time before/after self-admin1.71.93.51.1-0.90.0-1.7-1.71.9-1.8-1.7-1.3-0.7-1.51.50.7
Parametrial fat weight0.91.83.9-2.02.01.81.61.6-0.61.11.2-0.5-1.1-0.70.71.2
Pavlov. Cond. lever latency2.02.66.70.8-0.70.5-1.7-1.62.6-2.0-1.8-2.0-1.3-1.91.90.2
Pavlov. Cond. magazine entry latency2.53.26.1-1.61.50.12.42.4-2.02.42.51.71.01.6-1.7-0.3
Pavlov. Cond. change in total contacts1.51.63.4-0.20.1-0.91.21.1-1.21.61.51.91.41.6-1.6-0.1
Pavlov. Cond. index score2.43.16.2-1.91.80.62.42.3-2.52.22.21.40.51.3-1.30.5
Pavlov. Cond. latency score2.53.17.3-1.61.50.32.32.2-2.72.22.21.70.81.6-1.60.2
Pavlov. Cond. lever contacts0.91.03.3-0.80.70.01.21.1-1.81.21.11.10.61.0-1.00.3
Pavlov. Cond. magazine entry number3.34.17.81.4-1.20.5-2.6-2.52.0-2.8-2.7-2.2-1.6-2.12.20.6
Pavlov. Cond. intertrial magazine entries0.91.12.2-0.70.81.3-0.2-0.10.8-0.7-0.5-1.4-1.5-1.51.51.1
Pavlov. Cond. lever-magazine prob. diff.2.53.15.8-2.01.80.62.42.4-2.32.32.31.40.51.3-1.30.5
Pavlov. Cond. response bias2.63.25.8-1.41.2-0.22.32.2-2.12.42.42.01.21.8-1.8-0.3
Pavlov. Cond. lever latency0.71.02.00.9-1.0-1.4-0.0-0.1-1.10.50.41.31.21.2-1.2-1.1
Pavlov. Cond. magazine entry latency1.82.15.11.3-1.2-0.3-1.9-1.92.3-1.9-1.9-1.2-0.5-1.11.2-0.1
Pavlov. Cond. change in total contacts0.71.04.20.3-0.20.4-0.9-0.92.0-1.1-1.1-1.1-0.6-1.11.10.8
Pavlov. Cond. index score0.71.03.90.2-0.20.5-0.9-0.82.0-1.1-1.0-1.1-0.7-1.11.10.6
Pavlov. Cond. latency score0.91.13.50.2-0.10.6-0.9-0.81.9-1.2-1.1-1.3-0.9-1.31.30.7
Pavlov. Cond. lever contacts1.01.42.8-1.21.31.70.10.21.1-0.6-0.4-1.5-1.5-1.41.41.3
Pavlov. Cond. magazine entry number1.72.05.6-1.11.00.01.81.7-2.41.81.81.30.61.3-1.3-0.3
Pavlov. Cond. intertrial magazine entries1.01.33.1-1.71.81.51.31.4-0.90.81.0-0.5-1.1-0.50.40.7
Pavlov. Cond. lever-magazine prob. diff.0.81.14.50.4-0.30.3-1.0-1.02.1-1.2-1.1-1.1-0.6-1.11.10.5
Pavlov. Cond. response bias0.60.82.6-0.30.40.9-0.5-0.41.6-0.9-0.8-1.2-0.9-1.11.10.5
Time in closed arm before self-admin0.70.81.50.2-0.3-1.20.50.5-0.40.90.81.11.01.2-1.2-1.2
Time in closed arm after self-admin1.51.53.00.8-0.9-1.70.40.3-0.81.00.91.61.61.6-1.6-1.7
Time in open arm before self-admin0.50.51.10.4-0.30.5-0.8-0.80.2-0.9-0.9-0.7-0.5-1.01.10.7
Time in open arm after self-admin0.50.61.20.4-0.30.4-0.9-0.91.0-1.0-1.1-0.7-0.5-0.80.80.8
Bone: periosteal estimation1.02.14.9-2.22.22.01.51.6-1.10.91.0-0.6-1.2-0.60.61.8
Bone: periosteal perimeter2.33.77.1-2.32.20.92.62.6-2.72.42.41.30.31.2-1.20.8
Bone: post-yield work0.30.50.9-0.00.10.6-0.6-0.50.7-0.8-0.7-0.9-0.8-0.90.90.4
Progressive ratio test 1 active lever presses0.70.71.8-1.31.31.40.70.8-0.40.30.4-0.6-1.1-0.80.70.4
Progressive ratio test 1 breakpoint0.90.92.2-1.51.51.40.91.0-0.30.50.5-0.6-1.1-0.70.70.5
Progressive ratio test 1 inactive lever presses1.21.33.5-1.81.91.91.11.2-0.50.60.6-0.7-1.3-0.60.50.8
Progressive ratio test 2 active lever presses0.40.40.8-0.80.80.90.70.7-0.40.40.6-0.4-0.8-0.60.6-0.3
Progressive ratio test 2 breakpoint0.50.61.4-0.90.91.20.50.5-0.30.10.4-0.7-1.1-0.90.90.0
Progressive ratio test 2 inactive lever presses0.30.41.1-0.80.70.60.80.8-1.00.70.80.1-0.3-0.00.0-0.3
Incentive Sensitization - Responses0.30.30.5-0.60.60.60.60.50.50.30.6-0.5-0.7-0.60.6-0.6
Incentive Sensitization - Breakpoint0.30.30.5-0.50.50.50.50.50.40.30.6-0.4-0.6-0.50.5-0.7
Sum of active levers in priming session hrs 5-61.11.02.1-0.80.7-0.11.41.3-0.91.51.50.90.50.9-1.0-0.7
Progressive ratio0.20.20.70.8-0.8-0.5-0.6-0.7-0.2-0.4-0.40.10.40.1-0.1-0.6
Food seeking constrained by brief footshock0.50.61.60.5-0.5-0.90.20.1-0.70.50.40.90.91.2-1.2-1.3
Seeking ratio, punishment vs. effort0.10.10.2-0.50.50.40.30.30.20.10.2-0.3-0.4-0.10.10.0
Retroperitoneal fat weight2.27.417.4-4.24.23.73.03.1-1.31.91.9-1.0-2.2-1.11.03.4
Reaction time number correct4.46.411.4-0.40.62.3-1.8-1.62.9-2.7-2.6-3.3-2.8-3.43.42.7
Reaction time mean minus median0.50.71.60.4-0.5-1.00.20.2-0.70.70.41.31.21.2-1.2-0.2
Reaction time mean minus median AUC0.10.20.50.1-0.1-0.30.10.1-0.70.30.10.60.60.7-0.7-0.2
Reaction time num false alarms0.10.20.80.6-0.6-0.4-0.4-0.50.9-0.3-0.3-0.00.2-0.10.10.2
Reaction time num false alarms AUC0.40.51.21.0-1.0-0.5-0.9-1.01.1-0.8-0.8-0.20.2-0.40.40.2
Reaction time trials correct on left4.46.411.4-0.40.62.3-1.8-1.62.9-2.7-2.6-3.3-2.8-3.43.42.7
Reaction time trials on left4.66.611.8-0.40.62.3-1.9-1.62.9-2.8-2.6-3.4-2.8-3.43.42.8
Reaction time mean0.10.20.5-0.60.60.50.30.40.50.20.0-0.3-0.2-0.40.40.7
Reaction time mean AUC0.40.51.9-0.50.60.8-0.1-0.00.8-0.3-0.4-0.8-0.6-0.90.91.4
Median of all reaction times0.30.40.8-0.70.70.80.10.20.9-0.1-0.1-0.7-0.6-0.80.80.9
Reaction time omissions0.40.52.8-0.20.30.8-0.3-0.30.1-0.5-0.6-0.6-0.6-0.80.81.7
Reaction time false alarm rate0.91.22.51.0-1.2-1.60.1-0.1-0.50.70.61.41.51.4-1.4-1.2
Reaction time premature initiation rate0.50.61.81.3-1.3-1.0-0.9-1.00.4-0.6-0.50.00.4-0.10.1-0.8
Reaction time premature initiations1.72.43.91.0-0.80.4-1.8-1.72.0-2.0-1.8-1.8-1.1-1.91.90.9
Std. dev. reaction times0.20.30.60.7-0.7-0.5-0.7-0.60.8-0.4-0.60.10.50.1-0.00.2
Reaction time trials completed4.66.611.8-0.40.62.3-1.9-1.62.9-2.8-2.6-3.4-2.8-3.43.42.8
Reaction time trials AUC4.66.612.0-0.40.72.3-1.8-1.62.9-2.7-2.6-3.4-2.8-3.53.52.8
Run reversals in cocaine runway, females1.11.13.70.6-0.6-0.0-1.1-1.01.9-1.2-1.2-1.1-0.6-1.11.10.4
Run reversals in cocaine runway, males1.91.95.5-1.11.00.01.71.7-2.31.81.71.20.61.1-1.1-0.8
Latency to leave start box in cocaine runway0.50.63.20.5-0.4-0.1-0.7-0.81.8-0.8-0.7-0.6-0.3-0.50.50.6
Latency to leave start box in cocaine runway, F1.31.53.10.5-0.40.4-1.3-1.31.8-1.6-1.4-1.2-0.8-1.31.31.4
Latency to leave start box in cocaine runway, M0.20.20.4-0.30.3-0.10.60.50.60.50.70.20.00.4-0.4-0.1
Std. dev. time between licks in bursts3.23.97.5-0.91.12.3-0.9-0.71.6-1.7-1.5-2.7-2.7-2.72.62.2
Total sessions with >9 infusions0.30.40.80.5-0.50.2-0.6-0.6-0.1-0.6-0.6-0.5-0.4-0.90.9-0.8
Short access day 1 total inactive lever presses0.70.81.50.10.00.9-0.8-0.80.1-1.2-1.0-1.1-0.9-1.21.20.9
Short access day 10 total inactive lever presses2.02.24.8-2.22.21.32.12.1-1.21.51.80.2-0.70.6-0.60.0
Short access day 1 total infusions0.91.02.31.5-1.5-1.0-1.2-1.30.3-0.8-1.00.20.6-0.00.0-1.3
Short access day 10 total infusions0.50.51.0-0.90.80.80.90.9-0.90.70.8-0.1-0.6-0.30.2-1.0
Short access total infusions0.10.10.7-0.00.00.20.00.0-0.2-0.0-0.0-0.2-0.3-0.40.3-0.8
Short access day 1 locomotion0.30.41.20.8-0.8-0.8-0.3-0.3-0.60.1-0.10.60.70.2-0.2-1.1
Short access day 10 total locomotion0.60.72.50.3-0.4-0.70.40.3-1.00.80.71.00.90.9-0.9-1.6
Short access total locomotion0.40.42.60.7-0.7-0.8-0.1-0.2-0.70.20.20.60.60.4-0.4-1.6
One hour access (0.3 mA shock)1.01.22.9-1.51.61.70.91.0-0.30.30.6-1.0-1.5-1.11.00.4
Compulsive drug intake0.20.20.7-0.70.70.60.30.40.20.10.1-0.2-0.30.1-0.10.8
One hour access (shock baseline)0.50.61.8-0.50.61.10.00.1-0.4-0.3-0.2-1.0-1.3-1.31.3-0.0
Social response proportion0.40.40.80.7-0.6-0.1-0.9-0.90.8-0.8-0.8-0.5-0.2-0.50.6-0.2
Social responses0.30.30.80.4-0.40.2-0.8-0.80.3-0.8-0.9-0.5-0.3-0.50.50.6
Social time0.20.30.60.3-0.3-0.1-0.7-0.70.7-0.7-0.7-0.3-0.1-0.40.40.8
Soleus weight0.72.05.0-2.22.22.01.51.6-1.50.81.0-0.5-1.4-0.40.41.3
Bone: stiffness0.40.61.6-1.21.31.10.80.8-0.70.40.5-0.4-0.7-0.20.20.3
Tibialis anterior weight0.20.51.5-0.30.41.0-0.4-0.30.0-0.8-0.6-1.1-1.2-0.90.90.5
Time to tail flick, vehicle, before self-admin0.10.10.3-0.30.30.50.00.1-0.4-0.1-0.1-0.4-0.5-0.20.2-0.0
Time to tail flick, vehicle, after self-admin1.21.32.91.7-1.7-1.3-1.6-1.60.8-1.3-1.40.10.70.1-0.00.0
Time to tail flick, test, before self-admin0.40.42.1-0.30.30.20.60.6-0.80.50.90.2-0.20.2-0.2-1.4
Time to tail flick, test, after self-admin0.20.20.50.7-0.7-0.3-0.5-0.6-0.7-0.3-0.40.30.40.2-0.2-0.7
Delta time to tail flick, vehicle, before/after SA0.60.61.10.6-0.6-0.1-1.0-1.01.0-1.1-1.0-0.5-0.1-0.60.70.8
Delta time to tail flick, test, before/after SA0.50.51.20.9-1.0-1.0-0.5-0.50.10.0-0.30.81.10.6-0.60.1
Tibia length5.415.331.2-5.35.12.65.65.6-4.24.75.01.8-0.11.7-1.81.7
Ambulatory time before self-admin2.02.14.1-1.61.50.51.91.9-2.01.91.71.10.41.2-1.2-0.3
Ambulatory time after self-admin0.10.20.5-0.60.60.70.30.3-0.10.10.0-0.3-0.5-0.30.30.3
Bone: tissue strength1.01.02.6-1.31.31.60.40.5-0.2-0.20.0-1.1-1.4-1.01.01.2
Total heroin consumption1.41.74.30.1-0.3-1.10.70.6-1.11.20.82.01.92.1-2.1-0.5
Bone: trabecular number0.00.00.1-0.10.10.2-0.0-0.00.1-0.1-0.1-0.3-0.2-0.30.30.1
Bone: trabecular spacing2.22.85.5-0.50.71.9-1.0-0.91.4-1.7-1.5-2.3-2.3-2.32.31.7
Bone: trabecular thickness1.72.13.7-0.50.4-0.81.61.5-1.31.91.91.71.41.7-1.7-1.2
Bone: trabecular tissue density0.40.61.41.2-1.2-0.9-1.0-1.00.6-0.6-0.70.20.50.2-0.2-0.6
Water consumed over 24 hours1.01.23.40.3-0.4-0.90.40.3-1.30.70.61.41.11.6-1.6-1.8
Number of responses in last shaping day0.50.51.8-0.90.91.30.40.5-0.80.20.1-0.5-0.8-0.60.60.3