Hub : Genes

Asnsd1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Asnsd1	0.04	0.03	2.1e-03	0.02	0.02	0.02	0.02	6.6e-03	4.8e-03	4.2e-03	7.7e-03
2	Adipose	gene expression	Asnsd1	0.15	0.08	1.1e-16	0.07	0.07	0.06	0.07	1.9e-08	3.7e-08	1.1e-07	5.9e-08
3	Liver	intron excision ratio	chr9_48126949_48128543	0.03	0.03	1.5e-03	-0	0	0	-0	5.6e-01	1.6e-01	2.5e-01	6.4e-01
4	Liver	intron excision ratio	chr9_48126954_48128543	0.04	0.03	1.1e-03	-0	0	0	-0	5.0e-01	1.3e-01	1.8e-01	5.7e-01
5	PL	gene expression	Asnsd1	0.03	0.03	7.1e-03	0.02	0.02	0.02	0.02	5.1e-03	2.0e-03	2.3e-03	4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	2.0	3.3	4.7	2.0	2.2	-1.7	1.7	1.2
Area under the delay curve	0.1	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
BMI with tail	1.8	5.9	16.0	-4.0	-2.6	1.8	-1.8	-0.5
BMI without tail	0.3	0.6	2.7	-1.6	-0.2	-0.1	0.1	0.7
Body weight	0.1	0.2	0.3	-0.4	-0.4	0.6	-0.6	-0.5
Weight adjusted by age	1.7	1.9	3.5	-0.1	-1.2	1.5	-1.5	-1.9
Bone surface	0.1	0.2	0.6	0.5	0.2	0.4	-0.4	-0.8
Bone volume	0.5	0.9	2.3	1.5	1.3	-0.6	0.6	0.0
Breakpoint value in progressive ratio session	0.4	0.5	1.0	1.0	0.6	-0.7	0.6	0.4
Number of licking bursts	1.9	2.2	3.8	0.1	1.3	-1.6	1.7	1.9
Context. condit. distance diff. score	1.2	1.5	3.5	-0.4	0.5	-1.3	1.4	1.9
Locomotion velocity, session 1	0.1	0.1	0.2	-0.0	0.4	-0.3	0.4	0.4
Locomotion distance, session 1	0.3	0.4	0.5	-0.7	-0.6	0.6	-0.6	-0.5
Locomotion velocity, session 2	1.5	1.8	2.8	-1.7	-1.3	1.3	-1.3	-1.0
Locomotion distance, session 2	1.2	1.7	1.8	-1.4	-1.3	1.4	-1.3	-1.2
Locomotion velocity, session 3	0.2	0.2	0.9	-0.9	-0.2	0.1	-0.1	0.1
Locomotion distance, session 3	0.4	0.4	1.4	-1.2	0.1	-0.4	0.4	0.7
Stereotopy head waving bouts, day 3	0.4	0.5	0.8	-0.9	-0.7	0.6	-0.6	-0.4
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.0	0.0	-0.0	0.0	0.1
Locomotion velocity, session 7	1.9	2.1	2.8	-0.8	-1.3	1.6	-1.6	-1.7
Locomotion distance, session 7	1.3	1.7	2.1	-0.7	-1.3	1.5	-1.5	-1.4
Stereotopy head waving bouts, day 7	0.3	0.4	0.4	0.5	0.6	-0.7	0.7	0.6
Stereotopy head waving duration, day 7	0.5	0.6	1.0	1.0	0.9	-0.8	0.7	0.5
Locomotion velocity, session 8	0.1	0.1	0.3	-0.4	-0.0	-0.3	0.3	0.6
Locomotion distance, session 8	0.3	0.4	1.4	-1.2	-0.6	0.0	0.0	0.5
Degree of sensitization distance	1.5	1.5	2.8	0.5	-0.9	1.4	-1.4	-1.7
Degree of sensitization stereotypy	0.6	0.6	0.8	0.5	0.8	-0.9	0.9	0.8
Conditioned locomotion	0.1	0.1	0.2	0.1	0.4	-0.4	0.3	0.3
Cocaine response after cond. corrected	1.3	1.5	2.4	-0.1	-1.1	1.4	-1.4	-1.6
Cocaine response after cond. not corrected	1.8	2.0	4.0	0.5	-1.0	1.5	-1.5	-2.0
Cocaine response before conditioning	0.2	0.2	0.5	0.7	-0.1	0.3	-0.3	-0.7
Saline control response	0.4	0.5	0.9	-0.1	0.5	-0.8	0.8	1.0
Bone: connectivity density	0.1	0.2	0.4	0.3	0.6	-0.5	0.5	0.3
Bone: cortical apparent density	4.3	5.7	8.6	-2.9	-2.8	2.3	-2.2	-1.4
Bone: cortical area	0.9	1.4	2.2	-0.7	-1.0	1.3	-1.3	-1.5
Bone: cortical porosity	0.9	1.0	1.5	1.2	1.1	-1.0	0.9	0.6
Bone: cortical porosity	0.7	0.7	1.7	1.3	1.0	-0.7	0.7	0.3
Bone: cortical thickness	1.0	1.7	3.2	-1.8	-1.4	1.2	-1.1	-0.7
Bone: cortical thickness	0.2	0.2	0.4	-0.1	-0.3	0.5	-0.5	-0.6
Bone: cortical tissue density	4.3	5.7	8.7	-3.0	-2.8	2.3	-2.2	-1.4
Condit. Reinf. active minus inactive responses	2.9	3.2	5.1	2.3	2.2	-1.7	1.6	1.0
Condit. Reinf. active-inactive response ratio	1.8	2.0	3.1	1.8	1.7	-1.3	1.3	0.8
Condit. Reinf. active responses	1.8	2.2	5.9	2.4	1.7	-1.0	1.0	0.3
Condit. Reinf. inactive responses	0.2	0.3	0.5	0.7	-0.2	0.5	-0.5	-0.6
Incentive salience index mean	2.8	3.3	4.6	2.2	2.1	-1.8	1.7	1.2
Condit. Reinf. lever presses	1.6	2.1	2.3	1.4	1.4	-1.5	1.5	1.4
Condit. Reinf. active minus inactive responses	1.1	1.3	3.6	1.9	1.3	-0.8	0.8	0.1
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.3	1.5	1.5	-1.2	1.2	0.7
Condit. Reinf. active responses	0.3	0.4	1.6	1.3	0.3	-0.0	-0.0	-0.4
Condit. Reinf. inactive responses	0.5	0.7	1.0	0.1	-0.8	0.9	-0.9	-1.0
Condit. Reinf. lever presses	0.1	0.1	0.4	0.6	0.1	0.1	-0.1	-0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	1.3	1.1	0.2	0.2	-0.2	-0.7
Conditioned reinforcement - actives	0.1	0.1	0.3	0.1	0.5	-0.3	0.3	0.2
Conditioned reinforcement - inactives	0.0	0.1	0.2	0.3	0.2	0.0	-0.0	-0.4
Conditioned locomotion	4.4	5.3	6.1	-2.5	-2.3	2.4	-2.3	-2.0
Patch foraging indifference point 0 sec	1.6	2.6	6.2	-2.5	-1.7	1.3	-1.3	-0.6
Patch foraging indifference point AUC	0.8	0.9	1.3	-0.0	-0.9	1.1	-1.1	-1.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	-0.1	0.1	-0.2	0.2	0.2
Delay disc. indifference point, 16s delay	0.9	0.9	1.7	1.3	1.0	-0.8	0.8	0.7
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	-0.1
Delay disc. indifference point, 24s delay	0.6	0.6	1.1	0.2	0.6	-0.9	0.9	1.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.6	-0.4	0.4	-0.4	-0.2
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	0.9	0.5	-0.4	0.3	0.1
Indifference point function ln k	0.7	1.0	2.0	-1.0	0.3	-1.0	1.0	1.4
Indifference point function log k	0.7	1.0	2.0	-1.0	0.3	-1.0	1.0	1.4
Patch foraging total patch changes 0 sec	1.7	2.8	6.9	-2.6	-1.8	1.4	-1.3	-0.6
Patch foraging total patch changes 12 sec	0.5	0.7	0.9	-0.3	-0.8	1.0	-1.0	-0.8
Patch foraging total patch changes 18 sec	0.7	0.9	1.2	-1.0	-1.1	1.0	-0.9	-0.5
Patch foraging total patch changes 24 sec	0.6	0.8	1.3	-0.3	-1.1	1.0	-1.0	-0.7
Patch foraging total patch changes 6 sec	1.5	2.2	3.5	-1.9	-1.7	1.4	-1.4	-0.8
Patch foraging time to switch 0 sec	0.6	0.9	1.2	1.1	1.0	-0.9	0.9	0.6
Patch foraging water rate 0 sec	0.6	0.9	1.8	-1.3	-1.0	0.9	-0.9	-0.6
Patch foraging water rate 12 sec	0.2	0.3	0.6	-0.6	0.2	-0.5	0.5	0.8
Patch foraging water rate 18 sec	0.7	0.9	1.5	-0.1	0.9	-1.1	1.1	1.2
Patch foraging water rate 24 sec	0.0	0.0	0.0	-0.1	0.1	0.0	-0.1	-0.1
Patch foraging water rate 6 sec	0.2	0.3	0.7	-0.7	-0.1	-0.4	0.4	0.9
Seeking ratio, delayed vs. immediate footshock	0.6	0.6	1.6	1.3	1.0	-0.5	0.5	-0.0
Distance traveled before self-admin	1.0	1.1	4.1	2.0	0.7	-0.0	-0.1	-0.9
Distance traveled after self-admin	0.2	0.3	0.8	0.9	-0.1	0.2	-0.3	-0.7
Extensor digitorum longus weight	8.6	33.9	41.8	-5.2	-6.5	6.1	-6.0	-5.2
Bone: elastic displacement	1.8	2.0	3.0	0.2	1.4	-1.6	1.6	1.7
Bone: elastic work	0.5	0.6	1.1	1.0	1.1	-0.6	0.6	0.2
Bone: endosteal estimation	0.7	1.6	5.1	2.3	0.7	0.4	-0.5	-1.5
Bone: endosteal perimeter	0.2	0.5	1.2	1.1	0.5	0.2	-0.2	-0.9
Epididymis fat weight	0.1	0.3	0.8	0.6	-0.2	0.5	-0.5	-0.9
Delta time in closed arm before/after self-admin	1.3	1.2	1.4	-1.1	-1.1	1.2	-1.2	-1.0
Delta time in open arm before/after self-admin	2.1	2.0	3.4	1.8	1.5	-1.4	1.3	0.8
Diff in mean of infusions in LGA sessions	1.3	1.4	2.3	1.5	1.1	-1.2	1.2	0.8
Delay discount exponential model param	0.2	0.2	0.3	-0.4	-0.4	0.5	-0.5	-0.5
Extinction: sum of active levers before priming	0.7	0.7	2.1	1.4	0.8	-0.6	0.6	0.2
Active lever presses in extinction session 6	0.7	0.7	0.8	0.9	0.7	-0.9	0.9	0.8
Bone: final force	1.1	1.8	4.0	0.5	-0.8	1.5	-1.5	-2.0
Bone: final moment	1.0	1.6	3.3	0.2	-0.8	1.4	-1.5	-1.8
Food consumed during 24 hour testing period	0.4	0.4	1.0	0.3	-0.3	0.7	-0.7	-1.0
Glucose	0.7	1.0	2.3	-0.0	0.6	-1.1	1.1	1.5
Heart weight	0.0	0.1	0.2	0.4	0.2	0.0	-0.0	-0.3
Delay discount hyperbolic model param	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	-0.3
Intermittent access intake day 1-15 change	0.1	0.1	0.2	-0.3	-0.1	-0.2	0.2	0.5
Intermittent access intake escalation	0.2	0.2	0.5	0.1	0.3	-0.5	0.5	0.7
Intermittent access intake escalation 2	0.5	0.5	0.8	0.5	0.5	-0.8	0.8	0.9
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.5	-0.7	-0.3	0.2	-0.2	-0.1
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.2	0.4	0.3	-0.4	0.3	0.1
Intermitt. access escalation Index	0.2	0.1	0.3	-0.5	0.1	-0.2	0.3	0.6
Intermittent access day 1 total infusions	1.1	1.2	1.6	0.4	1.2	-1.3	1.3	1.1
Intermittent access day 15 total infusions	1.3	1.4	2.1	0.2	1.1	-1.3	1.4	1.5
Intermittent access terminal intake (last 3 days)	0.8	0.8	1.5	-0.1	0.8	-1.0	1.0	1.2
Intermittent access total infusions	0.9	1.0	1.3	0.2	1.0	-1.1	1.1	1.1
Intermittent access day 1 locomotion	0.1	0.1	0.3	-0.5	0.5	-0.3	0.3	0.3
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.3	0.0	0.1	-0.1	-0.1
Intermittent access total locomotion	0.2	0.3	0.9	-1.0	0.2	-0.3	0.3	0.4
Intermittent access standard deviation	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.2	-0.1
Left kidney weight	0.1	0.2	0.4	0.1	-0.3	0.5	-0.5	-0.6
Right kidney weight	0.7	1.8	2.4	-0.7	-1.2	1.5	-1.5	-1.6
Cocaine induced anxiety	3.5	4.1	5.6	-2.4	-2.3	2.0	-1.9	-1.4
Post-drug Anxiety	0.7	0.8	2.3	-1.5	-0.9	0.7	-0.7	-0.3
Baseline Anxiety	3.8	4.0	4.9	2.2	2.2	-2.0	2.0	1.6
Tail length	1.2	3.6	7.7	2.8	2.5	-1.5	1.4	0.3
Length with tail	0.8	2.8	9.7	3.1	1.7	-0.6	0.5	-0.8
Length without tail	1.2	2.6	4.7	0.4	-1.4	1.7	-1.8	-2.2
Times rat made contact with spout	1.8	2.1	3.5	0.2	1.2	-1.6	1.6	1.9
Lifetime Intake	0.2	0.3	0.4	-0.1	0.4	-0.6	0.6	0.6
Liver weight, left	1.4	2.3	3.8	-0.4	-1.1	1.7	-1.8	-2.0
Liver weight, right	0.3	0.6	1.2	0.3	-0.4	0.9	-0.9	-1.1
Locomotor activity	0.1	0.2	0.3	-0.4	-0.5	0.4	-0.4	-0.4
Locomotor testing distance	0.4	0.7	0.8	0.4	0.9	-0.9	0.9	0.9
Locomotor testing rearing	1.0	1.6	2.9	-0.4	1.1	-1.3	1.4	1.7
Locomotion in novel chamber	3.8	4.7	5.7	-1.5	-2.2	2.4	-2.4	-2.2
Locomotion in novel chamber post-restriction	3.6	4.4	5.0	-1.5	-2.2	2.2	-2.2	-2.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	-0.2	-0.0	-0.1	0.1	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.0	0.3	-0.5	0.5	0.6
Time >=10cm from walls, locomotor time 1	1.2	1.2	1.8	-0.4	-1.0	1.2	-1.2	-1.3
Bouts of movement, locomotor time 1	0.8	0.9	1.7	-1.3	-1.3	0.7	-0.7	-0.4
Total resting periods, locomotor time 1	1.4	1.5	2.5	-1.5	-1.6	1.1	-1.0	-0.7
Rest time, locomotor task time 1	0.2	0.2	0.5	-0.7	-0.0	-0.3	0.3	0.6
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.4	0.6	-0.3	0.3	0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.1	0.1	-0.1	0.2	-0.3	-0.3
Time >=10cm from walls, locomotor time 2	1.4	1.4	2.2	1.5	1.3	-1.2	1.2	0.8
Bouts of movement, locomotor time 2	2.3	2.4	4.2	-2.1	-2.0	1.3	-1.3	-0.7
Total resting periods, locomotor time 2	2.2	2.4	4.5	-2.1	-1.9	1.3	-1.2	-0.7
Rest time, locomotor task time 2	0.3	0.3	1.2	-1.1	-0.3	0.0	0.0	0.5
Distance moved, locomotor task time 2	0.2	0.3	0.8	0.9	0.6	-0.3	0.2	-0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.2	-0.1	-0.1	0.1	0.1
Light reinforcement 1	4.0	7.3	9.3	-2.7	-3.1	2.8	-2.7	-2.1
Light reinforcement 2	0.9	1.3	1.5	-1.1	-1.2	1.2	-1.2	-1.0
Bone: marrow area	0.7	1.5	4.8	2.2	0.6	0.4	-0.5	-1.4
Bone: maximum diameter	0.2	0.4	0.6	-0.4	-0.4	0.7	-0.7	-0.8
Bone: maximum force	1.3	2.3	5.1	1.1	-0.5	1.5	-1.5	-2.3
Bone: maximum moment	1.1	1.9	4.2	0.8	-0.6	1.4	-1.5	-2.1
Mean time between licks in bursts	3.0	4.1	4.9	-1.7	-2.2	2.2	-2.2	-1.9
Mean num. licks in bursts	0.3	0.4	0.6	-0.2	-0.7	0.7	-0.7	-0.8
Cd content in liver	0.3	0.3	0.8	0.5	-0.1	0.5	-0.6	-0.9
Co content in liver	1.9	2.2	2.7	1.0	1.5	-1.6	1.6	1.6
Cu content in liver	2.1	2.6	4.3	2.1	1.7	-1.5	1.5	1.1
Fe content in liver	2.3	2.7	4.0	1.8	2.0	-1.7	1.6	1.1
K content in liver	2.7	2.7	4.1	-1.1	-2.0	1.7	-1.7	-1.5
Mg content in liver	0.9	0.9	1.8	-0.6	-1.3	1.0	-1.0	-0.7
Mn content in liver	0.1	0.1	0.2	-0.4	-0.4	-0.1	0.2	0.4
Na content in liver	0.1	0.1	0.2	0.3	-0.4	0.3	-0.2	-0.2
Rb content in liver	2.4	2.9	4.0	-0.5	-2.0	1.9	-1.9	-1.8
Se content in liver	0.2	0.3	0.4	-0.7	-0.5	0.5	-0.5	-0.4
Sr content in liver	0.2	0.1	0.4	-0.6	0.1	-0.3	0.3	0.4
Zn content in liver	0.4	0.5	1.5	-1.2	-0.6	0.5	-0.5	-0.2
Bone: minimum diameter	0.8	1.5	3.3	0.2	-0.7	1.3	-1.4	-1.8
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.2	0.3	-0.5	0.5	0.8
Time in novel zone, hab. session 1	2.5	2.5	3.5	1.8	1.9	-1.6	1.5	1.0
Total zone transitions, hab. session 1	0.7	1.0	1.8	-0.4	-0.7	1.1	-1.1	-1.3
Total locomotion distance, hab. session 1	1.4	2.0	4.5	-0.2	-0.8	1.5	-1.6	-2.1
Locomotion velocity, hab. session 1	2.3	3.3	5.5	-1.0	-1.4	2.0	-2.0	-2.3
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.0	0.2	-0.4	0.4	0.5
Time in novel zone, hab. session 2	0.4	0.4	0.5	0.2	0.7	-0.6	0.6	0.7
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.2	0.1	-0.3	0.3	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.4	0.2	0.0	0.4	-0.4	-0.6
Locomotion velocity, hab. session 2	0.3	0.4	0.8	-0.0	-0.3	0.6	-0.7	-0.9
Novel to familiar place preference ratio	1.0	1.0	1.6	1.3	1.1	-1.0	0.9	0.6
Novelty place preference	1.2	1.2	1.4	1.1	1.2	-1.1	1.1	0.9
Time in novel zone, NPP test	1.5	1.6	1.9	1.2	1.4	-1.3	1.3	1.0
Total zone transitions, NPP test	0.1	0.2	0.3	-0.6	-0.5	0.4	-0.4	-0.2
Total locomotion distance, NPP test	0.3	0.3	0.7	-0.3	-0.2	0.6	-0.7	-0.9
Locomotion velocity, NPP test	0.5	0.8	1.1	-0.7	-0.6	1.0	-1.0	-1.1
Intraocular pressure	0.3	0.4	0.7	-0.4	0.5	-0.6	0.6	0.9
Delta distance traveled before/after self-admin	0.3	0.3	0.8	-0.9	-0.7	0.3	-0.2	0.1
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	-0.9	-0.8	0.4	-0.3	0.0
Parametrial fat weight	0.0	0.0	0.1	-0.4	-0.1	-0.1	0.1	0.2
Pavlov. Cond. lever latency	2.3	2.9	3.3	-1.6	-1.8	1.8	-1.8	-1.4
Pavlov. Cond. magazine entry latency	1.7	2.2	3.0	1.7	1.7	-1.5	1.4	0.9
Pavlov. Cond. change in total contacts	1.8	1.9	2.4	1.2	1.6	-1.5	1.4	1.1
Pavlov. Cond. index score	3.0	3.9	4.5	1.7	2.1	-2.1	2.1	1.8
Pavlov. Cond. latency score	2.8	3.5	4.1	1.7	2.0	-2.0	2.0	1.6
Pavlov. Cond. lever contacts	2.3	2.8	3.5	1.0	1.7	-1.9	1.9	1.7
Pavlov. Cond. magazine entry number	3.7	4.6	5.8	-2.3	-2.4	2.2	-2.2	-1.6
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	3.4	1.5	1.8	-1.8	1.8	1.5
Pavlov. Cond. response bias	2.9	3.6	4.2	1.6	2.0	-2.0	2.0	1.7
Pavlov. Cond. lever latency	0.3	0.3	1.6	-1.2	-0.4	0.1	-0.1	0.2
Pavlov. Cond. magazine entry latency	0.3	0.3	1.2	1.1	0.5	-0.1	0.1	-0.2
Pavlov. Cond. change in total contacts	0.7	0.9	2.6	1.6	1.1	-0.6	0.6	0.2
Pavlov. Cond. index score	0.4	0.6	2.3	1.5	0.6	-0.1	0.1	-0.3
Pavlov. Cond. latency score	0.4	0.5	2.1	1.4	0.6	0.0	-0.0	-0.4
Pavlov. Cond. lever contacts	0.4	0.6	2.3	1.5	0.6	-0.3	0.2	-0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.9	-1.4	-1.0	0.5	-0.5	-0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.4	-1.5	-1.0	0.5	-0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.5	1.2	0.4	0.1	-0.2	-0.4
Pavlov. Cond. response bias	0.5	0.7	3.1	1.8	0.5	0.0	-0.1	-0.5
Time in closed arm before self-admin	1.7	2.0	3.9	2.0	1.7	-1.2	1.2	0.7
Time in closed arm after self-admin	0.2	0.2	0.4	0.6	0.0	0.3	-0.3	-0.5
Time in open arm before self-admin	1.1	1.2	3.3	-1.8	-1.0	0.9	-0.8	-0.4
Time in open arm after self-admin	1.1	1.2	1.8	1.4	1.3	-1.1	1.0	0.6
Bone: periosteal estimation	0.5	1.1	2.6	1.2	0.1	0.8	-0.9	-1.6
Bone: periosteal perimeter	0.1	0.2	0.5	0.3	0.3	0.3	-0.3	-0.7
Bone: post-yield work	0.6	0.8	2.2	1.5	-0.1	0.6	-0.6	-1.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.2	-0.4	0.1	0.1	-0.1	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.5	-0.2	0.2	-0.2	-0.2
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.6	-0.8	-0.6	0.5	-0.5	-0.5
Progressive ratio test 2 active lever presses	0.4	0.4	0.5	0.5	0.6	-0.7	0.7	0.5
Progressive ratio test 2 breakpoint	0.5	0.5	0.7	0.3	0.7	-0.8	0.8	0.8
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.2	0.4	-0.5	0.5	0.4
Incentive Sensitization - Responses	0.3	0.3	0.5	0.7	0.7	-0.6	0.6	0.4
Incentive Sensitization - Breakpoint	0.3	0.3	0.4	0.5	0.6	-0.5	0.5	0.4
Sum of active levers in priming session hrs 5-6	1.1	1.1	2.9	1.7	1.0	-0.9	0.8	0.4
Progressive ratio	0.2	0.2	0.2	-0.4	-0.3	0.5	-0.5	-0.5
Food seeking constrained by brief footshock	0.6	0.7	1.1	0.2	-0.7	0.9	-1.0	-1.1
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	0.3	-0.5	0.5	-0.5	-0.6
Retroperitoneal fat weight	0.7	2.1	2.6	-0.9	-1.6	1.5	-1.5	-1.6
Reaction time number correct	0.7	1.0	1.4	-1.0	-1.2	1.0	-1.0	-0.6
Reaction time mean minus median	1.4	1.8	3.9	2.0	1.5	-1.1	1.1	0.6
Reaction time mean minus median AUC	1.2	1.6	3.1	1.7	1.4	-1.1	1.1	0.7
Reaction time num false alarms	3.9	5.2	7.4	-2.7	-2.6	2.2	-2.2	-1.6
Reaction time num false alarms AUC	5.1	7.0	8.9	-2.9	-3.0	2.6	-2.6	-2.1
Reaction time trials correct on left	0.7	1.0	1.4	-1.0	-1.2	1.0	-1.0	-0.6
Reaction time trials on left	0.7	0.9	1.3	-1.0	-1.1	1.0	-1.0	-0.6
Reaction time mean	3.3	4.6	8.4	2.9	2.4	-2.0	1.9	1.0
Reaction time mean AUC	3.0	4.1	7.1	2.7	2.3	-1.9	1.9	1.0
Median of all reaction times	3.1	4.3	6.7	2.6	2.4	-2.0	2.0	1.1
Reaction time omissions	1.7	2.3	2.9	0.9	1.7	-1.6	1.6	1.6
Reaction time false alarm rate	2.3	3.2	4.5	-2.1	-2.0	1.7	-1.7	-1.4
Reaction time premature initiation rate	0.0	0.1	0.1	-0.1	0.3	-0.2	0.2	0.2
Reaction time premature initiations	0.1	0.1	0.3	-0.5	-0.2	0.3	-0.3	-0.1
Std. dev. reaction times	3.2	4.4	8.7	2.9	2.4	-1.9	1.8	1.0
Reaction time trials completed	0.7	0.9	1.3	-1.0	-1.1	1.0	-1.0	-0.6
Reaction time trials AUC	0.6	0.8	1.1	-1.0	-1.1	0.9	-0.9	-0.5
Run reversals in cocaine runway, females	2.1	2.0	2.6	-0.6	-1.6	1.5	-1.5	-1.6
Run reversals in cocaine runway, males	1.4	1.3	1.6	-0.9	-1.2	1.3	-1.3	-1.1
Latency to leave start box in cocaine runway	3.7	4.0	7.3	-2.7	-2.3	1.8	-1.8	-1.0
Latency to leave start box in cocaine runway, F	1.5	1.7	4.2	-2.1	-1.5	1.0	-0.9	-0.3
Latency to leave start box in cocaine runway, M	3.7	3.5	3.9	-1.8	-2.0	2.0	-2.0	-1.7
Std. dev. time between licks in bursts	2.7	3.2	5.2	-2.3	-2.3	1.6	-1.5	-0.8
Total sessions with >9 infusions	3.1	3.4	3.8	-1.7	-1.8	1.9	-1.9	-1.9
Short access day 1 total inactive lever presses	0.8	0.9	0.9	-0.9	-0.9	1.0	-1.0	-0.9
Short access day 10 total inactive lever presses	0.0	0.0	0.2	0.4	0.1	-0.1	0.0	-0.2
Short access day 1 total infusions	0.8	0.9	1.3	-0.2	-0.9	1.0	-1.0	-1.2
Short access day 10 total infusions	1.4	1.5	2.4	0.3	1.0	-1.4	1.5	1.6
Short access total infusions	0.1	0.1	0.2	-0.4	-0.4	0.2	-0.2	-0.2
Short access day 1 locomotion	1.5	1.7	2.0	-0.8	-1.3	1.4	-1.4	-1.4
Short access day 10 total locomotion	0.1	0.1	0.3	-0.2	0.1	0.3	-0.4	-0.5
Short access total locomotion	3.0	3.1	3.6	-1.4	-1.8	1.9	-1.9	-1.9
One hour access (0.3 mA shock)	1.3	1.5	1.9	0.8	1.2	-1.4	1.4	1.3
Compulsive drug intake	0.1	0.1	0.1	0.1	0.0	-0.2	0.2	0.4
One hour access (shock baseline)	0.9	1.1	1.4	0.6	1.1	-1.2	1.2	1.0
Social response proportion	0.3	0.3	0.5	0.6	0.7	-0.6	0.6	0.4
Social responses	0.0	0.1	0.1	-0.4	-0.0	0.2	-0.2	-0.2
Social time	1.3	1.7	2.1	0.8	1.4	-1.4	1.4	1.3
Soleus weight	1.8	5.4	6.3	-1.7	-2.3	2.5	-2.5	-2.5
Bone: stiffness	1.6	2.6	5.6	1.0	-0.8	1.6	-1.7	-2.4
Tibialis anterior weight	3.5	12.1	16.2	-3.7	-4.0	3.4	-3.4	-2.6
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.4	-0.7	0.1	-0.2	0.2	0.5
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.4	0.5	0.7	-0.7	0.7	0.6
Time to tail flick, test, before self-admin	1.7	1.7	2.6	-1.0	-1.6	1.3	-1.3	-1.1
Time to tail flick, test, after self-admin	2.3	2.4	3.1	-1.8	-1.7	1.5	-1.5	-1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.8	0.9	0.3	-0.2	0.2	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.4	0.3	-0.2	0.2	0.3
Tibia length	1.0	2.9	9.8	3.1	0.7	0.5	-0.6	-1.9
Ambulatory time before self-admin	1.0	1.0	4.0	2.0	0.8	-0.1	0.1	-0.6
Ambulatory time after self-admin	0.3	0.3	0.5	0.1	-0.5	0.6	-0.6	-0.7
Bone: tissue strength	0.2	0.2	0.3	-0.6	-0.2	0.4	-0.4	-0.4
Total heroin consumption	0.7	0.8	1.1	0.8	0.8	-1.0	1.0	0.9
Bone: trabecular number	0.6	0.9	1.7	1.3	1.2	-0.8	0.8	0.4
Bone: trabecular spacing	0.8	1.1	1.4	-0.7	-1.2	1.1	-1.1	-1.0
Bone: trabecular thickness	4.7	5.6	8.1	2.3	2.8	-2.4	2.4	1.9
Bone: trabecular tissue density	0.2	0.3	1.0	1.0	-0.0	0.3	-0.3	-0.5
Water consumed over 24 hours	0.1	0.2	0.6	-0.8	-0.2	-0.0	0.1	0.4
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	-0.6	0.4	-0.3	-0.3