Hub : Genes

Asdurf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr9_55618940_55620534	0.03	0.03	1.7e-03	-0	0	-0	-0	4.6e-01	1.6e-01	3.9e-01	5.0e-01
2	Liver	intron excision ratio	chr9_55618945_55620534	0.03	0.03	1.3e-03	-0	0	-0	-0	4.0e-01	1.4e-01	3.8e-01	4.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.7	3.2	3.2	-1.8	1.8
Area under the delay curve	0.0	0.0	0.0	-0.1	0.1
BMI with tail	0.5	1.8	1.9	1.4	-1.3
BMI without tail	0.2	0.9	0.9	-0.9	1.0
Body weight	0.0	0.0	0.0	-0.1	0.1
Weight adjusted by age	0.6	1.8	1.8	1.3	-1.4
Bone surface	0.1	0.1	0.1	0.4	-0.4
Bone volume	0.2	0.4	0.5	-0.7	0.6
Breakpoint value in progressive ratio session	0.9	1.6	1.6	-1.3	1.3
Number of licking bursts	0.8	2.6	2.6	-1.6	1.6
Context. condit. distance diff. score	1.5	1.9	1.9	-1.3	1.4
Locomotion velocity, session 1	0.1	0.1	0.1	-0.4	0.4
Locomotion distance, session 1	0.4	0.5	0.5	0.7	-0.7
Locomotion velocity, session 2	1.5	1.8	1.8	1.4	-1.3
Locomotion distance, session 2	1.5	2.2	2.2	1.5	-1.5
Locomotion velocity, session 3	0.0	0.0	0.0	0.1	-0.1
Locomotion distance, session 3	0.2	0.2	0.2	-0.5	0.5
Stereotopy head waving bouts, day 3	0.3	0.4	0.4	0.6	-0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.0	0.0
Locomotion velocity, session 7	2.6	2.8	2.8	1.7	-1.7
Locomotion distance, session 7	1.5	1.9	1.9	1.4	-1.4
Stereotopy head waving bouts, day 7	0.4	0.5	0.5	-0.7	0.7
Stereotopy head waving duration, day 7	0.4	0.4	0.4	-0.7	0.7
Locomotion velocity, session 8	0.1	0.1	0.1	-0.3	0.3
Locomotion distance, session 8	0.0	0.0	0.0	0.1	-0.0
Degree of sensitization distance	1.6	1.8	1.8	1.3	-1.3
Degree of sensitization stereotypy	0.6	0.6	0.6	-0.8	0.8
Conditioned locomotion	0.0	0.0	0.0	0.0	-0.0
Cocaine response after cond. corrected	1.3	1.9	1.9	1.4	-1.4
Cocaine response after cond. not corrected	1.8	2.6	2.7	1.6	-1.6
Cocaine response before conditioning	0.3	0.3	0.3	0.5	-0.6
Saline control response	0.3	0.4	0.4	-0.6	0.6
Bone: connectivity density	0.1	0.2	0.2	-0.4	0.4
Bone: cortical apparent density	2.6	4.1	4.2	2.1	-2.0
Bone: cortical area	0.9	1.5	1.5	1.2	-1.2
Bone: cortical porosity	1.1	1.2	1.2	-1.1	1.1
Bone: cortical porosity	0.6	0.7	0.7	-0.8	0.8
Bone: cortical thickness	0.6	1.1	1.1	1.0	-1.0
Bone: cortical thickness	0.4	0.5	0.6	0.7	-0.7
Bone: cortical tissue density	2.5	4.0	4.1	2.0	-2.0
Condit. Reinf. active minus inactive responses	2.3	2.6	2.7	-1.6	1.6
Condit. Reinf. active-inactive response ratio	1.6	1.7	1.7	-1.3	1.3
Condit. Reinf. active responses	0.7	0.9	1.0	-1.0	0.9
Condit. Reinf. inactive responses	0.2	0.3	0.3	0.5	-0.5
Incentive salience index mean	2.3	3.0	3.1	-1.8	1.7
Condit. Reinf. lever presses	1.5	2.3	2.3	-1.5	1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.3	-0.6	0.5
Condit. Reinf. active-inactive response ratio	0.8	1.2	1.3	-1.1	1.1
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. inactive responses	0.8	1.2	1.2	1.1	-1.1
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.0	-0.0
Condit. Reinf. lever reinforcers received	0.1	0.2	0.2	0.4	-0.5
Conditioned reinforcement - actives	0.0	0.0	0.1	0.2	-0.2
Conditioned reinforcement - inactives	0.1	0.3	0.3	0.6	-0.6
Conditioned locomotion	3.5	5.2	5.3	2.3	-2.3
Patch foraging indifference point 0 sec	0.4	1.1	1.1	1.0	-1.0
Patch foraging indifference point AUC	0.5	1.2	1.2	1.1	-1.1
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	-0.1
Delay disc. indifference point, 16s delay	0.5	0.7	0.7	-0.8	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	0.3	-0.3
Delay disc. indifference point, 24s delay	0.4	0.6	0.7	-0.8	0.8
Delay disc. indifference point, 4s delay	0.2	0.2	0.2	0.5	-0.5
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	-0.2	0.2
Indifference point function ln k	0.3	0.8	0.9	-0.9	0.9
Indifference point function log k	0.3	0.8	0.9	-0.9	0.9
Patch foraging total patch changes 0 sec	0.4	1.2	1.2	1.1	-1.1
Patch foraging total patch changes 12 sec	0.5	0.7	0.7	0.9	-0.9
Patch foraging total patch changes 18 sec	0.3	0.7	0.8	0.9	-0.8
Patch foraging total patch changes 24 sec	0.3	0.9	0.9	1.0	-0.9
Patch foraging total patch changes 6 sec	1.0	1.7	1.8	1.3	-1.3
Patch foraging time to switch 0 sec	0.2	0.8	0.8	-0.9	0.9
Patch foraging water rate 0 sec	0.1	0.4	0.4	0.7	-0.6
Patch foraging water rate 12 sec	0.0	0.2	0.2	-0.4	0.4
Patch foraging water rate 18 sec	0.5	1.1	1.1	-1.0	1.0
Patch foraging water rate 24 sec	0.0	0.0	0.0	0.1	-0.1
Patch foraging water rate 6 sec	0.1	0.1	0.2	-0.4	0.4
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.1	-0.4	0.3
Distance traveled before self-admin	0.2	0.4	0.5	-0.7	0.6
Distance traveled after self-admin	0.1	0.2	0.2	-0.4	0.4
Extensor digitorum longus weight	8.7	34.6	34.9	5.9	-5.9
Bone: elastic displacement	2.6	3.3	3.3	-1.8	1.8
Bone: elastic work	0.4	0.5	0.6	-0.7	0.7
Bone: endosteal estimation	0.1	0.2	0.2	0.4	-0.5
Bone: endosteal perimeter	0.0	0.0	0.0	0.1	-0.2
Epididymis fat weight	0.4	1.9	2.0	1.4	-1.4
Delta time in closed arm before/after self-admin	0.4	0.3	0.4	0.6	-0.6
Delta time in open arm before/after self-admin	0.6	0.7	0.7	-0.9	0.8
Diff in mean of infusions in LGA sessions	0.4	0.7	0.7	-0.8	0.8
Delay discount exponential model param	0.0	0.0	0.0	0.1	-0.1
Extinction: sum of active levers before priming	0.7	1.1	1.1	-1.1	1.1
Active lever presses in extinction session 6	0.6	0.6	0.6	-0.8	0.8
Bone: final force	1.0	1.6	1.6	1.2	-1.3
Bone: final moment	0.9	1.4	1.4	1.2	-1.2
Food consumed during 24 hour testing period	0.3	0.6	0.6	0.8	-0.8
Glucose	1.4	2.2	2.2	-1.5	1.5
Heart weight	0.0	0.0	0.0	-0.0	-0.0
Delay discount hyperbolic model param	0.0	0.0	0.0	0.1	-0.1
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.0	0.0
Intermittent access intake escalation	0.0	0.0	0.0	-0.1	0.1
Intermittent access intake escalation 2	0.3	0.5	0.5	-0.7	0.7
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.1	0.2
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.1	0.3	-0.2
Intermitt. access escalation Index	0.2	0.6	0.6	-0.8	0.8
Intermittent access day 1 total infusions	0.4	1.3	1.3	-1.1	1.1
Intermittent access day 15 total infusions	0.3	0.6	0.7	-0.8	0.8
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.3	-0.5	0.6
Intermittent access total infusions	0.5	0.6	0.6	-0.7	0.8
Intermittent access day 1 locomotion	0.0	0.0	0.0	-0.1	0.1
Intermittent access day 15 total locomotion	0.2	0.8	0.8	0.9	-0.9
Intermittent access total locomotion	0.0	0.0	0.0	0.2	-0.2
Intermittent access standard deviation	0.0	0.2	0.2	0.5	-0.5
Left kidney weight	0.0	0.3	0.3	-0.6	0.5
Right kidney weight	0.1	0.9	0.9	0.9	-0.9
Cocaine induced anxiety	0.4	1.1	1.1	1.1	-1.0
Post-drug Anxiety	1.3	1.4	1.5	1.2	-1.2
Baseline Anxiety	0.1	0.2	0.3	-0.5	0.5
Tail length	1.1	6.0	6.2	-2.5	2.4
Length with tail	0.5	2.0	2.2	-1.5	1.4
Length without tail	0.1	0.7	0.7	0.8	-0.9
Times rat made contact with spout	2.4	2.7	2.8	-1.6	1.7
Lifetime Intake	0.0	0.0	0.0	-0.2	0.2
Liver weight, left	0.1	0.1	0.1	0.3	-0.4
Liver weight, right	0.0	0.0	0.0	-0.1	0.1
Locomotor activity	0.1	0.1	0.1	0.3	-0.3
Locomotor testing distance	0.3	0.7	0.7	-0.9	0.9
Locomotor testing rearing	0.5	1.7	1.7	-1.3	1.3
Locomotion in novel chamber	4.3	5.7	5.7	2.4	-2.4
Locomotion in novel chamber post-restriction	2.0	5.9	5.9	2.4	-2.4
Fecal boli incidents, locomotor time 1	0.1	0.2	0.2	-0.5	0.5
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	-0.2	0.2
Time >=10cm from walls, locomotor time 1	1.3	1.6	1.6	1.3	-1.3
Bouts of movement, locomotor time 1	0.4	0.5	0.5	0.7	-0.7
Total resting periods, locomotor time 1	1.0	1.1	1.2	1.1	-1.0
Rest time, locomotor task time 1	0.1	0.2	0.2	-0.4	0.4
Distance moved, locomotor task time 1	0.1	0.2	0.2	-0.5	0.5
Vertical activity count, locomotor time 1	0.0	0.0	0.0	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.4	1.2	1.2	-1.1	1.1
Bouts of movement, locomotor time 2	0.6	2.0	2.0	1.4	-1.4
Total resting periods, locomotor time 2	0.4	1.8	1.9	1.4	-1.3
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.0	0.1
Distance moved, locomotor task time 2	0.0	0.1	0.1	-0.3	0.2
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	0.1
Light reinforcement 1	1.6	7.4	7.6	2.7	-2.7
Light reinforcement 2	0.5	1.2	1.3	1.1	-1.1
Bone: marrow area	0.1	0.2	0.3	0.4	-0.5
Bone: maximum diameter	0.1	0.2	0.2	0.5	-0.5
Bone: maximum force	1.0	2.0	2.1	1.4	-1.4
Bone: maximum moment	0.9	1.8	1.8	1.3	-1.3
Mean time between licks in bursts	0.7	4.0	4.1	2.0	-2.0
Mean num. licks in bursts	0.2	0.4	0.4	0.6	-0.7
Cd content in liver	3.8	4.3	4.3	-2.1	2.1
Co content in liver	3.4	4.0	4.0	-2.0	2.0
Cu content in liver	1.6	1.9	1.9	-1.4	1.4
Fe content in liver	3.9	4.9	4.9	-2.2	2.2
K content in liver	3.1	3.1	3.1	1.8	-1.7
Mg content in liver	0.3	0.3	0.3	0.6	-0.5
Mn content in liver	0.0	0.0	0.0	0.1	-0.1
Na content in liver	0.0	0.0	0.0	0.1	-0.1
Rb content in liver	5.2	6.1	6.1	2.5	-2.5
Se content in liver	0.2	0.2	0.2	0.4	-0.4
Sr content in liver	0.0	0.0	0.0	-0.0	0.1
Zn content in liver	0.0	0.0	0.0	-0.0	0.0
Bone: minimum diameter	0.8	1.5	1.6	1.2	-1.3
Time in familiar zone, hab. session 1	0.3	0.3	0.3	-0.5	0.6
Time in novel zone, hab. session 1	2.0	2.2	2.2	-1.5	1.5
Total zone transitions, hab. session 1	1.1	1.6	1.6	1.2	-1.3
Total locomotion distance, hab. session 1	2.2	3.1	3.2	1.7	-1.8
Locomotion velocity, hab. session 1	3.4	4.8	4.9	2.2	-2.2
Time in familiar zone, hab. session 2	0.2	0.2	0.2	-0.5	0.5
Time in novel zone, hab. session 2	0.3	0.4	0.4	-0.6	0.6
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.2	0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.3	0.5	-0.5
Locomotion velocity, hab. session 2	0.5	0.7	0.7	0.8	-0.8
Novel to familiar place preference ratio	0.6	0.8	0.8	-0.9	0.9
Novelty place preference	0.9	1.2	1.2	-1.1	1.1
Time in novel zone, NPP test	1.3	1.6	1.6	-1.3	1.3
Total zone transitions, NPP test	0.2	0.3	0.3	0.6	-0.5
Total locomotion distance, NPP test	0.4	0.6	0.6	0.8	-0.8
Locomotion velocity, NPP test	0.8	1.2	1.2	1.1	-1.1
Intraocular pressure	0.1	0.2	0.2	-0.4	0.4
Delta distance traveled before/after self-admin	0.0	0.0	0.0	0.2	-0.2
Delta ambulatory time before/after self-admin	0.1	0.2	0.2	0.5	-0.4
Parametrial fat weight	0.0	0.0	0.0	-0.0	0.0
Pavlov. Cond. lever latency	3.0	3.8	3.8	1.9	-1.9
Pavlov. Cond. magazine entry latency	2.0	2.6	2.6	-1.6	1.6
Pavlov. Cond. change in total contacts	2.0	2.2	2.2	-1.5	1.5
Pavlov. Cond. index score	3.7	4.7	4.8	-2.2	2.2
Pavlov. Cond. latency score	3.4	4.3	4.4	-2.1	2.1
Pavlov. Cond. lever contacts	3.2	3.9	3.9	-2.0	2.0
Pavlov. Cond. magazine entry number	3.4	4.3	4.4	2.1	-2.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	3.0	3.7	3.8	-1.9	1.9
Pavlov. Cond. response bias	3.7	4.6	4.6	-2.1	2.1
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	-0.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.3
Pavlov. Cond. change in total contacts	0.2	0.4	0.4	-0.7	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	-0.1
Pavlov. Cond. lever contacts	0.1	0.2	0.2	-0.5	0.4
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.3	0.5	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.0	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.1	-0.3	0.3
Time in closed arm before self-admin	0.5	1.0	1.0	-1.0	1.0
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	0.1
Time in open arm before self-admin	0.5	0.7	0.7	0.8	-0.8
Time in open arm after self-admin	0.2	0.2	0.2	-0.5	0.4
Bone: periosteal estimation	0.3	0.6	0.7	0.8	-0.8
Bone: periosteal perimeter	0.0	0.0	0.0	-0.0	0.0
Bone: post-yield work	0.2	0.3	0.3	0.5	-0.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.0	0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	0.0	0.0
Progressive ratio test 1 inactive lever presses	0.3	0.7	0.7	0.8	-0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.1	0.1
Progressive ratio test 2 breakpoint	0.1	0.1	0.1	-0.2	0.3
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.0	-0.1	0.1
Incentive Sensitization - Responses	0.1	0.4	0.4	-0.6	0.6
Incentive Sensitization - Breakpoint	0.1	0.3	0.3	-0.6	0.6
Sum of active levers in priming session hrs 5-6	0.8	0.8	0.8	-0.9	0.9
Progressive ratio	0.4	1.2	1.2	1.1	-1.1
Food seeking constrained by brief footshock	0.9	1.1	1.1	1.0	-1.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.2	0.4	-0.4
Retroperitoneal fat weight	0.5	2.4	2.4	1.5	-1.5
Reaction time number correct	0.3	1.0	1.0	1.0	-1.0
Reaction time mean minus median	0.2	1.2	1.2	-1.1	1.1
Reaction time mean minus median AUC	0.2	1.2	1.3	-1.1	1.1
Reaction time num false alarms	2.2	3.7	3.8	1.9	-1.9
Reaction time num false alarms AUC	2.3	5.3	5.4	2.3	-2.3
Reaction time trials correct on left	0.3	1.0	1.0	1.0	-1.0
Reaction time trials on left	0.3	1.0	1.0	1.0	-1.0
Reaction time mean	1.7	3.8	3.9	-2.0	1.9
Reaction time mean AUC	1.5	3.6	3.7	-1.9	1.9
Median of all reaction times	2.6	4.1	4.3	-2.1	2.0
Reaction time omissions	1.1	1.7	1.7	-1.3	1.3
Reaction time false alarm rate	1.5	2.1	2.1	1.5	-1.4
Reaction time premature initiation rate	0.1	0.1	0.1	-0.4	0.4
Reaction time premature initiations	0.0	0.0	0.0	0.1	-0.1
Std. dev. reaction times	1.0	3.3	3.4	-1.8	1.8
Reaction time trials completed	0.3	1.0	1.0	1.0	-1.0
Reaction time trials AUC	0.2	0.8	0.8	0.9	-0.9
Run reversals in cocaine runway, females	1.2	1.4	1.4	1.2	-1.2
Run reversals in cocaine runway, males	1.0	1.1	1.1	1.0	-1.0
Latency to leave start box in cocaine runway	2.1	2.9	2.9	1.7	-1.7
Latency to leave start box in cocaine runway, F	0.6	0.8	0.8	0.9	-0.8
Latency to leave start box in cocaine runway, M	4.0	3.8	3.9	2.0	-2.0
Std. dev. time between licks in bursts	1.2	2.3	2.4	1.6	-1.5
Total sessions with >9 infusions	2.4	3.0	3.0	1.7	-1.7
Short access day 1 total inactive lever presses	2.0	4.0	4.0	2.0	-2.0
Short access day 10 total inactive lever presses	0.0	0.1	0.1	0.3	-0.3
Short access day 1 total infusions	2.0	4.0	4.0	2.0	-2.0
Short access day 10 total infusions	0.4	0.7	0.7	-0.8	0.9
Short access total infusions	0.1	0.1	0.1	0.3	-0.3
Short access day 1 locomotion	2.7	4.4	4.4	2.1	-2.1
Short access day 10 total locomotion	0.1	0.3	0.3	0.5	-0.5
Short access total locomotion	1.9	2.9	3.0	1.7	-1.7
One hour access (0.3 mA shock)	0.4	0.4	0.4	-0.7	0.7
Compulsive drug intake	0.8	1.1	1.1	1.1	-1.1
One hour access (shock baseline)	0.4	0.9	0.9	-1.0	1.0
Social response proportion	0.3	0.3	0.3	-0.6	0.6
Social responses	0.0	0.0	0.0	0.2	-0.2
Social time	1.6	2.5	2.5	-1.6	1.6
Soleus weight	1.7	5.1	5.1	2.3	-2.3
Bone: stiffness	1.7	3.0	3.1	1.7	-1.8
Tibialis anterior weight	3.3	11.5	11.7	3.4	-3.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.4	0.4
Time to tail flick, vehicle, after self-admin	0.6	1.3	1.3	-1.1	1.1
Time to tail flick, test, before self-admin	2.5	2.9	2.9	1.7	-1.7
Time to tail flick, test, after self-admin	3.6	3.8	3.8	1.9	-1.9
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.3	-0.6	0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.3	0.3
Tibia length	0.1	0.2	0.3	0.4	-0.5
Ambulatory time before self-admin	0.3	0.8	0.9	-0.9	0.9
Ambulatory time after self-admin	0.2	0.3	0.3	-0.5	0.5
Bone: tissue strength	0.0	0.0	0.0	-0.1	0.1
Total heroin consumption	1.9	2.3	2.3	-1.5	1.5
Bone: trabecular number	0.6	1.1	1.2	-1.1	1.1
Bone: trabecular spacing	1.1	1.6	1.6	1.3	-1.3
Bone: trabecular thickness	5.4	7.4	7.5	-2.7	2.7
Bone: trabecular tissue density	0.1	0.1	0.1	0.3	-0.4
Water consumed over 24 hours	0.0	0.1	0.1	-0.3	0.3
Number of responses in last shaping day	0.0	0.0	0.0	-0.2	0.2