Hub : Genes

Asdurf

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr9_48126949_48128543 0.03 0.03 1.5e-03 -0 0 0 -0 5.6e-01 1.6e-01 2.5e-01 6.5e-01
2 Liver intron excision ratio chr9_48126954_48128543 0.04 0.03 1.1e-03 -0 0 0 -0 5.0e-01 1.3e-01 1.8e-01 5.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.83.03.0-1.71.7
Area under the delay curve0.10.10.1-0.40.4
BMI with tail1.03.23.41.8-1.8
BMI without tail0.00.00.0-0.10.1
Body weight0.10.30.30.6-0.6
Weight adjusted by age2.02.32.41.5-1.5
Bone surface0.10.10.20.4-0.4
Bone volume0.20.40.4-0.60.6
Breakpoint value in progressive ratio session0.40.40.4-0.70.6
Number of licking bursts2.32.72.8-1.61.7
Context. condit. distance diff. score1.51.81.8-1.31.4
Locomotion velocity, session 10.10.10.1-0.30.4
Locomotion distance, session 10.30.40.40.6-0.6
Locomotion velocity, session 21.51.81.81.3-1.3
Locomotion distance, session 21.31.81.81.4-1.3
Locomotion velocity, session 30.00.00.00.1-0.1
Locomotion distance, session 30.20.20.2-0.40.4
Stereotopy head waving bouts, day 30.30.40.40.6-0.6
Stereotopy head waving duration, day 30.00.00.0-0.00.0
Locomotion velocity, session 72.42.62.71.6-1.6
Locomotion distance, session 71.72.12.11.5-1.5
Stereotopy head waving bouts, day 70.40.40.4-0.70.7
Stereotopy head waving duration, day 70.50.60.6-0.80.7
Locomotion velocity, session 80.10.10.1-0.30.3
Locomotion distance, session 80.00.00.00.00.0
Degree of sensitization distance1.91.91.91.4-1.4
Degree of sensitization stereotypy0.70.80.8-0.90.9
Conditioned locomotion0.10.10.1-0.40.3
Cocaine response after cond. corrected1.82.02.01.4-1.4
Cocaine response after cond. not corrected2.12.32.41.5-1.5
Cocaine response before conditioning0.10.10.10.3-0.3
Saline control response0.50.60.6-0.80.8
Bone: connectivity density0.10.20.2-0.50.5
Bone: cortical apparent density3.85.05.12.3-2.2
Bone: cortical area1.21.81.81.3-1.3
Bone: cortical porosity0.80.90.9-1.00.9
Bone: cortical porosity0.50.50.5-0.70.7
Bone: cortical thickness0.81.31.41.2-1.1
Bone: cortical thickness0.20.20.20.5-0.5
Bone: cortical tissue density3.85.05.12.3-2.2
Condit. Reinf. active minus inactive responses2.42.72.8-1.71.6
Condit. Reinf. active-inactive response ratio1.51.61.7-1.31.3
Condit. Reinf. active responses0.81.01.1-1.01.0
Condit. Reinf. inactive responses0.20.30.30.5-0.5
Incentive salience index mean2.53.13.1-1.81.7
Condit. Reinf. lever presses1.72.32.3-1.51.5
Condit. Reinf. active minus inactive responses0.50.60.7-0.80.8
Condit. Reinf. active-inactive response ratio1.41.51.5-1.21.2
Condit. Reinf. active responses0.00.00.0-0.0-0.0
Condit. Reinf. inactive responses0.70.90.90.9-0.9
Condit. Reinf. lever presses0.00.00.00.1-0.1
Condit. Reinf. lever reinforcers received0.00.00.10.2-0.2
Conditioned reinforcement - actives0.10.10.1-0.30.3
Conditioned reinforcement - inactives0.00.00.00.0-0.0
Conditioned locomotion4.65.55.52.4-2.3
Patch foraging indifference point 0 sec1.01.71.71.3-1.3
Patch foraging indifference point AUC1.11.31.31.1-1.1
Delay disc. indifference point, 0s delay0.00.00.0-0.20.2
Delay disc. indifference point, 16s delay0.70.70.7-0.80.8
Delay disc. indifference point, 2s delay0.00.00.00.1-0.1
Delay disc. indifference point, 24s delay0.80.80.8-0.90.9
Delay disc. indifference point, 4s delay0.10.20.20.4-0.4
Delay disc. indifference point, 8s delay0.10.10.1-0.40.3
Indifference point function ln k0.71.01.0-1.01.0
Indifference point function log k0.71.01.0-1.01.0
Patch foraging total patch changes 0 sec1.11.81.81.4-1.3
Patch foraging total patch changes 12 sec0.70.90.91.0-1.0
Patch foraging total patch changes 18 sec0.70.90.91.0-0.9
Patch foraging total patch changes 24 sec0.81.01.01.0-1.0
Patch foraging total patch changes 6 sec1.32.02.01.4-1.4
Patch foraging time to switch 0 sec0.50.80.9-0.90.9
Patch foraging water rate 0 sec0.50.80.80.9-0.9
Patch foraging water rate 12 sec0.20.20.2-0.50.5
Patch foraging water rate 18 sec0.91.21.2-1.11.1
Patch foraging water rate 24 sec0.00.00.00.0-0.1
Patch foraging water rate 6 sec0.10.20.2-0.40.4
Seeking ratio, delayed vs. immediate footshock0.20.30.3-0.50.5
Distance traveled before self-admin0.00.00.0-0.0-0.1
Distance traveled after self-admin0.10.10.10.2-0.3
Extensor digitorum longus weight9.336.737.06.1-6.0
Bone: elastic displacement2.32.62.6-1.61.6
Bone: elastic work0.30.40.4-0.60.6
Bone: endosteal estimation0.10.20.20.4-0.5
Bone: endosteal perimeter0.00.00.10.2-0.2
Epididymis fat weight0.10.20.20.5-0.5
Delta time in closed arm before/after self-admin1.41.41.41.2-1.2
Delta time in open arm before/after self-admin1.91.81.9-1.41.3
Diff in mean of infusions in LGA sessions1.31.41.4-1.21.2
Delay discount exponential model param0.20.20.20.5-0.5
Extinction: sum of active levers before priming0.40.40.4-0.60.6
Active lever presses in extinction session 60.90.80.8-0.90.9
Bone: final force1.42.22.31.5-1.5
Bone: final moment1.32.02.11.4-1.5
Food consumed during 24 hour testing period0.40.50.50.7-0.7
Glucose0.81.21.3-1.11.1
Heart weight0.00.00.00.0-0.0
Delay discount hyperbolic model param0.00.00.00.2-0.2
Intermittent access intake day 1-15 change0.00.00.0-0.20.2
Intermittent access intake escalation0.30.30.3-0.50.5
Intermittent access intake escalation 20.70.70.7-0.80.8
Intermitt. access day 1 inactive lever presses0.00.10.10.2-0.2
Intermitt. access day 15 inactive lever presses0.10.10.1-0.40.3
Intermitt. access escalation Index0.10.10.1-0.20.3
Intermittent access day 1 total infusions1.41.61.6-1.31.3
Intermittent access day 15 total infusions1.61.81.8-1.31.4
Intermittent access terminal intake (last 3 days)1.01.01.1-1.01.0
Intermittent access total infusions1.21.31.3-1.11.1
Intermittent access day 1 locomotion0.10.10.1-0.30.3
Intermittent access day 15 total locomotion0.00.00.00.1-0.1
Intermittent access total locomotion0.10.10.1-0.30.3
Intermittent access standard deviation0.00.00.00.2-0.2
Left kidney weight0.10.30.30.5-0.5
Right kidney weight0.82.42.41.5-1.5
Cocaine induced anxiety3.33.83.82.0-1.9
Post-drug Anxiety0.40.50.50.7-0.7
Baseline Anxiety3.73.94.0-2.02.0
Tail length0.72.02.1-1.51.4
Length with tail0.10.30.4-0.60.5
Length without tail1.43.13.21.7-1.8
Times rat made contact with spout2.32.72.7-1.61.6
Lifetime Intake0.30.40.4-0.60.6
Liver weight, left1.93.13.11.7-1.8
Liver weight, right0.50.80.80.9-0.9
Locomotor activity0.10.10.10.4-0.4
Locomotor testing distance0.50.80.8-0.90.9
Locomotor testing rearing1.21.81.9-1.31.4
Locomotion in novel chamber4.65.65.72.4-2.4
Locomotion in novel chamber post-restriction4.25.05.02.2-2.2
Fecal boli incidents, locomotor time 10.00.00.0-0.10.1
Change in fecal boli incidents, locomotor task0.30.20.3-0.50.5
Time >=10cm from walls, locomotor time 11.41.51.51.2-1.2
Bouts of movement, locomotor time 10.50.50.50.7-0.7
Total resting periods, locomotor time 11.01.11.21.1-1.0
Rest time, locomotor task time 10.10.10.1-0.30.3
Distance moved, locomotor task time 10.10.10.1-0.30.3
Vertical activity count, locomotor time 10.10.10.10.2-0.3
Time >=10cm from walls, locomotor time 21.31.41.4-1.21.2
Bouts of movement, locomotor time 21.61.71.81.3-1.3
Total resting periods, locomotor time 21.51.61.71.3-1.2
Rest time, locomotor task time 20.00.00.00.00.0
Distance moved, locomotor task time 20.10.10.1-0.30.2
Vertical activity count, locomotor time 20.00.00.0-0.10.1
Light reinforcement 14.27.67.82.8-2.7
Light reinforcement 21.01.41.41.2-1.2
Bone: marrow area0.10.20.20.4-0.5
Bone: maximum diameter0.20.40.50.7-0.7
Bone: maximum force1.32.32.41.5-1.5
Bone: maximum moment1.22.12.11.4-1.5
Mean time between licks in bursts3.34.64.72.2-2.2
Mean num. licks in bursts0.40.50.50.7-0.7
Cd content in liver0.30.30.30.5-0.6
Co content in liver2.32.62.7-1.61.6
Cu content in liver1.92.32.4-1.51.5
Fe content in liver2.22.72.7-1.71.6
K content in liver3.03.03.01.7-1.7
Mg content in liver0.90.91.01.0-1.0
Mn content in liver0.00.00.0-0.10.2
Na content in liver0.10.10.10.3-0.2
Rb content in liver2.93.63.61.9-1.9
Se content in liver0.20.20.20.5-0.5
Sr content in liver0.10.10.1-0.30.3
Zn content in liver0.20.30.30.5-0.5
Bone: minimum diameter1.01.81.91.3-1.4
Time in familiar zone, hab. session 10.30.30.3-0.50.5
Time in novel zone, hab. session 12.42.42.4-1.61.5
Total zone transitions, hab. session 10.81.21.21.1-1.1
Total locomotion distance, hab. session 11.72.52.61.5-1.6
Locomotion velocity, hab. session 12.94.14.22.0-2.0
Time in familiar zone, hab. session 20.20.20.2-0.40.4
Time in novel zone, hab. session 20.40.40.4-0.60.6
Total zone transitions, hab. session 20.10.10.1-0.30.3
Total locomotion distance, hab. session 20.10.10.10.4-0.4
Locomotion velocity, hab. session 20.30.40.40.6-0.7
Novel to familiar place preference ratio0.90.90.9-1.00.9
Novelty place preference1.31.31.3-1.11.1
Time in novel zone, NPP test1.61.71.7-1.31.3
Total zone transitions, NPP test0.10.20.20.4-0.4
Total locomotion distance, NPP test0.30.40.40.6-0.7
Locomotion velocity, NPP test0.70.90.91.0-1.0
Intraocular pressure0.30.40.4-0.60.6
Delta distance traveled before/after self-admin0.10.10.10.3-0.2
Delta ambulatory time before/after self-admin0.10.10.10.4-0.3
Parametrial fat weight0.00.00.0-0.10.1
Pavlov. Cond. lever latency2.63.23.31.8-1.8
Pavlov. Cond. magazine entry latency1.62.12.1-1.51.4
Pavlov. Cond. change in total contacts2.02.12.2-1.51.4
Pavlov. Cond. index score3.54.44.5-2.12.1
Pavlov. Cond. latency score3.14.04.0-2.02.0
Pavlov. Cond. lever contacts3.03.53.5-1.91.9
Pavlov. Cond. magazine entry number3.84.74.82.2-2.2
Pavlov. Cond. intertrial magazine entries0.10.10.10.3-0.3
Pavlov. Cond. lever-magazine prob. diff.2.73.43.4-1.81.8
Pavlov. Cond. response bias3.44.14.2-2.02.0
Pavlov. Cond. lever latency0.00.00.00.1-0.1
Pavlov. Cond. magazine entry latency0.00.00.0-0.10.1
Pavlov. Cond. change in total contacts0.30.40.4-0.60.6
Pavlov. Cond. index score0.00.00.0-0.10.1
Pavlov. Cond. latency score0.00.00.00.0-0.0
Pavlov. Cond. lever contacts0.00.10.1-0.30.2
Pavlov. Cond. magazine entry number0.20.20.30.5-0.5
Pavlov. Cond. intertrial magazine entries0.20.30.30.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1-0.2
Pavlov. Cond. response bias0.00.00.00.0-0.1
Time in closed arm before self-admin1.21.41.4-1.21.2
Time in closed arm after self-admin0.10.10.10.3-0.3
Time in open arm before self-admin0.60.70.70.9-0.8
Time in open arm after self-admin1.01.11.1-1.11.0
Bone: periosteal estimation0.30.70.70.8-0.9
Bone: periosteal perimeter0.00.10.10.3-0.3
Bone: post-yield work0.30.30.40.6-0.6
Progressive ratio test 1 active lever presses0.00.00.00.1-0.1
Progressive ratio test 1 breakpoint0.10.10.10.2-0.2
Progressive ratio test 1 inactive lever presses0.20.30.30.5-0.5
Progressive ratio test 2 active lever presses0.40.50.5-0.70.7
Progressive ratio test 2 breakpoint0.60.70.7-0.80.8
Progressive ratio test 2 inactive lever presses0.20.20.2-0.50.5
Incentive Sensitization - Responses0.30.30.3-0.60.6
Incentive Sensitization - Breakpoint0.30.30.3-0.50.5
Sum of active levers in priming session hrs 5-60.70.70.7-0.90.8
Progressive ratio0.20.20.20.5-0.5
Food seeking constrained by brief footshock0.70.90.90.9-1.0
Seeking ratio, punishment vs. effort0.20.20.20.5-0.5
Retroperitoneal fat weight0.72.32.31.5-1.5
Reaction time number correct0.71.11.11.0-1.0
Reaction time mean minus median0.91.21.3-1.11.1
Reaction time mean minus median AUC0.91.21.2-1.11.1
Reaction time num false alarms3.54.84.92.2-2.2
Reaction time num false alarms AUC4.96.86.82.6-2.6
Reaction time trials correct on left0.71.11.11.0-1.0
Reaction time trials on left0.71.01.11.0-1.0
Reaction time mean2.73.84.0-2.01.9
Reaction time mean AUC2.73.63.7-1.91.9
Median of all reaction times2.94.04.1-2.02.0
Reaction time omissions2.02.72.7-1.61.6
Reaction time false alarm rate2.12.92.91.7-1.7
Reaction time premature initiation rate0.00.10.1-0.20.2
Reaction time premature initiations0.10.10.10.3-0.3
Std. dev. reaction times2.43.33.5-1.91.8
Reaction time trials completed0.71.01.11.0-1.0
Reaction time trials AUC0.60.80.90.9-0.9
Run reversals in cocaine runway, females2.42.32.31.5-1.5
Run reversals in cocaine runway, males1.61.61.61.3-1.3
Latency to leave start box in cocaine runway2.93.23.31.8-1.8
Latency to leave start box in cocaine runway, F0.80.91.01.0-0.9
Latency to leave start box in cocaine runway, M4.03.93.92.0-2.0
Std. dev. time between licks in bursts2.02.52.51.6-1.5
Total sessions with >9 infusions3.43.73.81.9-1.9
Short access day 1 total inactive lever presses0.80.90.91.0-1.0
Short access day 10 total inactive lever presses0.00.00.0-0.10.0
Short access day 1 total infusions1.01.11.11.0-1.0
Short access day 10 total infusions1.92.12.1-1.41.5
Short access total infusions0.00.00.00.2-0.2
Short access day 1 locomotion1.81.91.91.4-1.4
Short access day 10 total locomotion0.10.10.10.3-0.4
Short access total locomotion3.33.53.51.9-1.9
One hour access (0.3 mA shock)1.61.91.9-1.41.4
Compulsive drug intake0.10.10.1-0.20.2
One hour access (shock baseline)1.21.41.4-1.21.2
Social response proportion0.30.30.3-0.60.6
Social responses0.00.10.10.2-0.2
Social time1.62.12.1-1.41.4
Soleus weight2.26.36.32.5-2.5
Bone: stiffness1.82.82.91.6-1.7
Tibialis anterior weight3.411.711.93.4-3.4
Time to tail flick, vehicle, before self-admin0.00.00.0-0.20.2
Time to tail flick, vehicle, after self-admin0.40.40.4-0.70.7
Time to tail flick, test, before self-admin1.81.81.81.3-1.3
Time to tail flick, test, after self-admin2.22.32.31.5-1.5
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.20.2
Delta time to tail flick, test, before/after SA0.10.00.0-0.20.2
Tibia length0.10.30.40.5-0.6
Ambulatory time before self-admin0.00.00.0-0.10.1
Ambulatory time after self-admin0.30.30.30.6-0.6
Bone: tissue strength0.10.10.10.4-0.4
Total heroin consumption0.91.11.1-1.01.0
Bone: trabecular number0.40.70.7-0.80.8
Bone: trabecular spacing0.91.21.21.1-1.1
Bone: trabecular thickness4.75.75.7-2.42.4
Bone: trabecular tissue density0.10.10.10.3-0.3
Water consumed over 24 hours0.00.00.0-0.00.1
Number of responses in last shaping day0.10.10.10.4-0.3