Ascc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	NM_001109091.1	0.04	0.02	2.0e-04	0.03	0.03	0.02	0.02	2.1e-04	8.1e-04	1.8e-03	1.0e-03
2	Liver	isoform ratio	XM_039092296.2	0.04	0.03	7.3e-04	0.03	0.02	0.02	0.02	4.8e-04	2.7e-03	3.9e-03	1.1e-03
3	Liver	alternative polyA	NM_001109091.1	0.03	0.02	3.9e-04	0.02	0.02	0.02	0.02	2.3e-03	1.6e-03	4.6e-03	2.9e-03
4	Liver	alternative polyA	XM_039092296.2	0.03	0.02	3.1e-04	0.02	0.02	0.02	0.02	1.6e-03	1.2e-03	4.2e-03	3.1e-03
5	Liver	alternative polyA	XM_039092296.2	0.03	0.02	4.9e-04	0.01	0.02	0.01	0.02	8.0e-03	1.7e-03	6.8e-03	6.4e-03
6	Liver	isoform ratio	NM_001109091.1	0.03	0.02	8.9e-04	0.02	0.02	0.02	0.02	4.6e-03	3.2e-03	6.6e-03	6.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.8	1.4	1.6	1.1	-1.2	1.2	-1.2	-1.2	1.2
Area under the delay curve	6.0	7.0	10.7	-3.1	3.3	-2.4	2.4	2.3	-2.3
BMI with tail	0.6	1.9	2.2	-1.5	1.4	-1.3	1.3	1.3	-1.4
BMI without tail	0.1	0.3	1.0	-1.0	0.8	-0.3	0.3	0.3	-0.2
Body weight	1.4	6.3	10.3	-3.2	3.0	-2.2	2.2	2.1	-2.0
Weight adjusted by age	0.2	0.3	0.9	-1.0	0.9	-0.3	0.3	0.3	-0.2
Bone surface	0.0	0.0	0.0	-0.1	0.0	0.0	-0.0	-0.0	0.1
Bone volume	0.0	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.3	0.3
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.5	0.5	-0.5	0.5	0.5	-0.4
Number of licking bursts	0.7	1.2	2.5	-1.6	1.6	-0.8	0.8	0.8	-0.7
Context. condit. distance diff. score	2.6	3.1	5.4	2.2	-2.3	1.5	-1.5	-1.5	1.4
Locomotion velocity, session 1	0.5	0.5	0.9	0.2	-0.2	-0.8	0.8	0.9	-0.9
Locomotion distance, session 1	2.6	3.3	4.0	1.9	-2.0	1.7	-1.7	-1.7	1.7
Locomotion velocity, session 2	0.5	0.6	1.0	0.2	-0.2	-0.9	0.9	1.0	-1.0
Locomotion distance, session 2	1.0	1.4	3.0	1.7	-1.7	0.9	-0.9	-0.8	0.7
Locomotion velocity, session 3	1.8	2.0	2.2	1.5	-1.4	1.4	-1.5	-1.4	1.3
Locomotion distance, session 3	0.2	0.3	0.4	-0.5	0.6	-0.5	0.5	0.5	-0.5
Stereotopy head waving bouts, day 3	1.4	1.7	2.1	1.4	-1.5	1.2	-1.3	-1.2	1.2
Stereotopy head waving duration, day 3	2.4	2.8	4.5	2.0	-2.1	1.5	-1.5	-1.4	1.4
Locomotion velocity, session 7	0.0	0.1	0.1	0.1	0.1	-0.3	0.3	0.3	-0.3
Locomotion distance, session 7	0.4	0.5	1.2	1.1	-1.0	0.4	-0.4	-0.3	0.4
Stereotopy head waving bouts, day 7	0.1	0.2	0.5	-0.7	0.6	-0.2	0.2	0.2	-0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.3	-0.5	0.4	0.1	-0.1	-0.2	0.2
Locomotion velocity, session 8	0.4	0.5	1.4	1.1	-1.2	0.1	-0.1	-0.0	-0.1
Locomotion distance, session 8	6.4	9.3	15.7	3.8	-4.0	2.6	-2.6	-2.5	2.4
Degree of sensitization distance	2.9	3.0	6.2	2.3	-2.5	1.3	-1.3	-1.2	1.2
Degree of sensitization stereotypy	0.3	0.3	0.9	-0.9	0.8	-0.4	0.4	0.3	-0.3
Conditioned locomotion	1.4	1.6	1.9	0.9	-1.1	1.4	-1.4	-1.4	1.3
Cocaine response after cond. corrected	0.4	0.5	0.9	-0.9	1.0	-0.6	0.7	0.6	-0.5
Cocaine response after cond. not corrected	0.6	0.7	1.4	-1.2	1.2	-0.6	0.6	0.5	-0.4
Cocaine response before conditioning	0.1	0.1	0.1	0.0	-0.2	0.4	-0.4	-0.4	0.3
Saline control response	0.6	0.8	1.9	1.3	-1.4	0.6	-0.6	-0.5	0.5
Bone: connectivity density	0.9	1.4	1.4	1.2	-1.1	1.2	-1.2	-1.2	1.2
Bone: cortical apparent density	0.1	0.2	0.3	-0.5	0.5	-0.3	0.3	0.3	-0.2
Bone: cortical area	0.9	1.3	2.4	-1.6	1.5	-1.0	1.0	0.9	-0.8
Bone: cortical porosity	0.1	0.1	0.3	-0.5	0.5	0.1	-0.1	-0.2	0.2
Bone: cortical porosity	0.1	0.1	0.2	-0.1	0.1	0.4	-0.4	-0.5	0.4
Bone: cortical thickness	0.3	0.6	1.6	-1.2	1.3	-0.4	0.3	0.2	-0.2
Bone: cortical thickness	1.8	2.2	2.7	1.2	-1.1	1.6	-1.6	-1.6	1.6
Bone: cortical tissue density	0.2	0.2	0.4	-0.6	0.6	-0.4	0.4	0.4	-0.4
Condit. Reinf. active minus inactive responses	0.5	0.5	0.9	0.1	0.0	-0.9	0.9	1.0	-0.9
Condit. Reinf. active-inactive response ratio	1.0	1.0	1.7	0.2	-0.1	-1.2	1.2	1.3	-1.3
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.3	-0.4	0.4	0.4	-0.4
Condit. Reinf. inactive responses	0.2	0.2	0.3	0.2	-0.1	0.5	-0.5	-0.6	0.6
Incentive salience index mean	0.7	0.9	1.2	-0.5	0.6	-1.1	1.1	1.1	-1.0
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.6	0.7	-0.5	0.5	0.5	-0.5
Condit. Reinf. active minus inactive responses	1.0	1.3	2.5	1.3	-1.6	0.9	-0.9	-0.9	0.9
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.2	0.2	-0.5	0.1	-0.1	-0.1	0.0
Condit. Reinf. active responses	1.7	2.4	4.9	2.0	-2.2	1.2	-1.2	-1.1	1.1
Condit. Reinf. inactive responses	1.5	2.0	4.0	2.0	-1.9	1.1	-1.1	-1.0	1.0
Condit. Reinf. lever presses	0.7	1.0	1.4	1.2	-1.2	0.9	-0.9	-0.9	0.8
Condit. Reinf. lever reinforcers received	1.6	2.2	4.5	2.0	-2.1	1.2	-1.1	-1.1	1.1
Conditioned reinforcement - actives	1.1	1.8	2.5	-1.6	1.6	-1.2	1.2	1.2	-1.2
Conditioned reinforcement - inactives	2.5	3.6	5.3	-2.2	2.3	-1.7	1.7	1.7	-1.7
Conditioned locomotion	1.1	1.4	2.7	-1.5	1.6	-1.0	1.0	0.9	-0.9
Patch foraging indifference point 0 sec	0.1	0.2	0.2	-0.5	0.4	-0.4	0.4	0.4	-0.3
Patch foraging indifference point AUC	0.1	0.1	0.3	0.5	-0.4	0.0	-0.0	0.0	0.1
Delay disc. indifference point, 0s delay	2.9	3.1	6.1	-2.3	2.5	-1.4	1.4	1.3	-1.3
Delay disc. indifference point, 16s delay	6.0	6.6	7.1	-2.6	2.7	-2.6	2.6	2.5	-2.5
Delay disc. indifference point, 2s delay	2.1	2.3	5.5	-2.2	2.3	-1.0	1.0	0.8	-0.9
Delay disc. indifference point, 24s delay	3.4	3.8	4.7	-2.2	2.1	-1.9	1.9	1.8	-1.9
Delay disc. indifference point, 4s delay	2.2	2.3	5.2	-2.0	2.3	-1.1	1.1	1.0	-1.0
Delay disc. indifference point, 8s delay	1.8	2.2	3.0	-1.6	1.7	-1.4	1.4	1.3	-1.3
Indifference point function ln k	0.3	0.6	0.7	0.5	-0.6	0.8	-0.8	-0.8	0.9
Indifference point function log k	0.3	0.6	0.7	0.5	-0.6	0.8	-0.8	-0.8	0.9
Patch foraging total patch changes 0 sec	0.2	0.3	0.4	-0.6	0.5	-0.6	0.6	0.6	-0.5
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	-0.1	0.2	-0.3	0.2	0.2	-0.1
Patch foraging total patch changes 18 sec	1.2	1.9	2.3	-1.1	1.1	-1.5	1.5	1.5	-1.4
Patch foraging total patch changes 24 sec	0.7	1.3	2.7	1.6	-1.7	0.8	-0.8	-0.7	0.7
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	-0.3	0.4	-0.5	0.5	0.5	-0.4
Patch foraging time to switch 0 sec	0.0	0.0	0.0	-0.2	0.1	0.1	-0.1	-0.2	0.1
Patch foraging water rate 0 sec	0.3	0.6	0.9	-0.5	0.7	-0.9	0.9	0.9	-0.8
Patch foraging water rate 12 sec	0.1	0.2	0.2	0.4	-0.4	0.4	-0.4	-0.4	0.5
Patch foraging water rate 18 sec	2.7	4.2	5.1	1.8	-1.8	2.1	-2.1	-2.1	2.3
Patch foraging water rate 24 sec	0.1	0.1	0.3	0.4	-0.5	-0.1	0.1	0.1	-0.1
Patch foraging water rate 6 sec	0.2	0.2	0.4	0.3	-0.3	0.5	-0.5	-0.5	0.6
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	0.0	-0.0
Distance traveled before self-admin	0.1	0.2	0.3	-0.1	-0.0	0.5	-0.5	-0.5	0.6
Distance traveled after self-admin	0.3	0.3	0.5	-0.2	0.2	0.6	-0.6	-0.7	0.7
Extensor digitorum longus weight	1.2	4.6	8.0	-2.8	2.7	-1.9	1.9	1.7	-1.6
Bone: elastic displacement	0.6	0.7	1.0	0.7	-0.5	1.0	-1.0	-1.0	1.0
Bone: elastic work	0.5	0.6	1.1	0.3	-0.1	0.9	-0.9	-1.0	1.0
Bone: endosteal estimation	0.0	0.0	0.0	-0.0	-0.2	-0.1	0.1	0.0	-0.0
Bone: endosteal perimeter	0.3	0.7	1.0	-1.0	0.6	-0.9	0.9	0.8	-0.8
Epididymis fat weight	0.5	1.7	3.6	-1.9	1.8	-1.0	1.0	0.9	-0.9
Delta time in closed arm before/after self-admin	5.3	4.9	6.2	2.5	-2.5	2.1	-2.1	-2.1	1.9
Delta time in open arm before/after self-admin	8.0	7.9	9.5	-3.1	3.0	-2.7	2.7	2.7	-2.6
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	-0.3	0.3	0.0	-0.0	-0.0	0.0
Delay discount exponential model param	5.7	6.4	9.9	3.0	-3.1	2.3	-2.3	-2.2	2.2
Extinction: sum of active levers before priming	1.5	1.7	1.9	-1.2	1.2	-1.3	1.3	1.3	-1.4
Active lever presses in extinction session 6	0.3	0.3	0.9	-0.9	1.0	-0.2	0.2	0.2	-0.2
Bone: final force	0.1	0.1	0.2	-0.4	0.4	-0.3	0.3	0.3	-0.3
Bone: final moment	0.1	0.1	0.2	-0.5	0.5	-0.3	0.3	0.2	-0.2
Food consumed during 24 hour testing period	0.9	1.2	1.8	-0.5	0.5	-1.3	1.3	1.3	-1.2
Glucose	25.9	40.8	48.1	-5.3	5.3	-6.8	6.9	6.9	-6.8
Heart weight	0.8	1.2	1.7	-0.8	0.7	-1.2	1.2	1.3	-1.3
Delay discount hyperbolic model param	5.5	6.1	10.0	3.0	-3.2	2.2	-2.2	-2.0	2.1
Intermittent access intake day 1-15 change	1.2	2.4	2.8	-1.2	1.3	-1.7	1.7	1.7	-1.7
Intermittent access intake escalation	1.1	2.2	2.5	-1.2	1.3	-1.6	1.6	1.6	-1.6
Intermittent access intake escalation 2	0.6	0.7	0.8	-0.8	0.9	-0.8	0.8	0.8	-0.8
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0	-0.0
Intermitt. access day 15 inactive lever presses	1.2	2.4	3.1	-1.1	1.1	-1.7	1.7	1.8	-1.7
Intermitt. access escalation Index	0.3	0.4	1.1	0.9	-1.0	-0.2	0.2	0.3	-0.3
Intermittent access day 1 total infusions	1.0	1.6	3.7	-1.9	1.8	-0.9	0.8	0.7	-0.8
Intermittent access day 15 total infusions	3.1	4.7	6.5	-2.5	2.4	-2.0	2.0	1.9	-1.9
Intermittent access terminal intake (last 3 days)	2.2	2.9	4.3	-2.1	2.0	-1.6	1.5	1.5	-1.5
Intermittent access total infusions	2.4	2.8	4.7	-2.2	2.1	-1.5	1.5	1.4	-1.4
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.2	0.1	0.4	-0.4	-0.4	0.4
Intermittent access day 15 total locomotion	2.1	3.9	6.1	-2.3	2.5	-1.8	1.8	1.7	-1.7
Intermittent access total locomotion	1.7	2.0	3.3	-1.7	1.8	-1.2	1.2	1.2	-1.2
Intermittent access standard deviation	0.0	0.1	0.1	-0.1	0.2	0.2	-0.2	-0.3	0.2
Left kidney weight	0.3	1.2	1.9	0.7	-0.6	1.2	-1.2	-1.3	1.4
Right kidney weight	0.5	2.5	4.0	0.5	-0.5	1.8	-1.8	-1.9	2.0
Cocaine induced anxiety	1.6	2.2	2.5	-1.6	1.6	-1.5	1.5	1.5	-1.4
Post-drug Anxiety	2.8	3.0	4.0	-1.8	2.0	-1.7	1.7	1.6	-1.6
Baseline Anxiety	0.2	0.3	0.3	-0.4	0.6	-0.5	0.5	0.5	-0.6
Tail length	0.3	1.1	3.1	-1.8	1.7	-0.5	0.5	0.4	-0.1
Length with tail	0.4	1.7	4.2	-2.0	2.0	-0.9	0.9	0.7	-0.5
Length without tail	0.3	1.0	1.8	-1.3	1.3	-0.9	0.9	0.8	-0.8
Times rat made contact with spout	1.1	1.3	2.0	-0.5	0.5	-1.3	1.3	1.4	-1.4
Lifetime Intake	1.8	2.2	4.1	-2.0	1.9	-1.3	1.2	1.2	-1.2
Liver weight, left	1.5	2.5	2.8	1.3	-1.5	1.6	-1.6	-1.7	1.7
Liver weight, right	1.4	2.5	2.6	1.5	-1.6	1.6	-1.6	-1.6	1.5
Locomotor activity	1.1	1.8	1.9	-1.3	1.2	-1.4	1.4	1.4	-1.3
Locomotor testing distance	0.2	0.3	1.0	-1.0	0.9	-0.1	0.1	0.1	-0.0
Locomotor testing rearing	1.0	2.0	3.0	-1.7	1.6	-1.3	1.3	1.3	-1.2
Locomotion in novel chamber	1.1	1.4	1.9	0.8	-0.9	1.3	-1.4	-1.4	1.2
Locomotion in novel chamber post-restriction	0.4	0.7	1.9	1.4	-1.3	0.4	-0.4	-0.3	0.2
Fecal boli incidents, locomotor time 1	0.1	0.2	0.4	0.7	-0.6	0.2	-0.2	-0.2	0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.1	-0.2	-0.5	0.5	0.6	-0.6
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	0.2	-0.2
Bouts of movement, locomotor time 1	0.5	0.6	1.0	-0.3	0.2	-0.9	0.9	1.0	-0.9
Total resting periods, locomotor time 1	0.7	0.8	1.2	-0.4	0.2	-1.0	1.0	1.1	-1.1
Rest time, locomotor task time 1	0.1	0.1	0.1	0.1	-0.3	-0.3	0.3	0.3	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	0.5	0.2	-0.2	-0.2	0.3
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.3	0.3	-0.0	0.0	-0.0	0.0
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.2	0.5	-0.2	0.0	-0.0	0.0	0.0
Bouts of movement, locomotor time 2	0.1	0.2	0.3	0.6	-0.5	0.3	-0.3	-0.3	0.4
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.5	-0.4	0.1	-0.1	-0.1	0.2
Rest time, locomotor task time 2	0.2	0.3	1.0	0.7	-1.0	0.3	-0.3	-0.2	0.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.2	0.3	-0.0	0.0	-0.0	-0.0
Light reinforcement 1	0.0	0.1	0.1	0.0	-0.1	0.3	-0.3	-0.3	0.3
Light reinforcement 2	0.2	0.2	0.4	0.1	-0.3	0.5	-0.5	-0.6	0.7
Bone: marrow area	0.0	0.0	0.0	0.0	-0.2	-0.0	0.0	0.0	0.0
Bone: maximum diameter	3.0	5.7	6.0	-2.4	2.3	-2.4	2.4	2.4	-2.3
Bone: maximum force	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.1	0.1
Bone: maximum moment	0.0	0.0	0.1	-0.2	0.2	0.1	-0.1	-0.2	0.2
Mean time between licks in bursts	0.2	0.5	0.8	0.2	-0.2	-0.8	0.8	0.9	-0.8
Mean num. licks in bursts	0.3	0.5	1.4	1.2	-1.1	-0.1	0.1	0.2	-0.3
Cd content in liver	1.0	1.1	1.3	-0.9	0.9	-1.1	1.1	1.1	-1.1
Co content in liver	0.1	0.1	0.3	-0.6	0.6	-0.1	0.1	0.1	-0.1
Cu content in liver	0.1	0.1	0.1	0.0	-0.1	-0.3	0.3	0.3	-0.3
Fe content in liver	0.7	0.9	1.8	1.3	-1.3	0.7	-0.7	-0.6	0.5
K content in liver	0.6	0.6	1.7	-1.3	1.3	-0.3	0.3	0.2	-0.2
Mg content in liver	1.3	1.3	2.8	-1.5	1.7	-0.9	0.9	0.8	-0.9
Mn content in liver	0.1	0.1	0.1	-0.2	0.4	0.3	-0.3	-0.4	0.4
Na content in liver	3.7	3.9	4.6	-2.2	2.0	-2.0	1.9	1.9	-1.9
Rb content in liver	0.4	0.5	0.9	-1.0	0.8	-0.6	0.6	0.6	-0.5
Se content in liver	0.8	1.0	2.4	-1.5	1.5	-0.6	0.6	0.5	-0.5
Sr content in liver	4.0	3.4	3.8	-1.9	1.9	-1.8	1.8	1.8	-1.8
Zn content in liver	0.1	0.1	0.1	0.1	0.0	0.3	-0.3	-0.3	0.3
Bone: minimum diameter	0.2	0.3	0.4	0.5	-0.6	0.6	-0.6	-0.6	0.6
Time in familiar zone, hab. session 1	0.4	0.4	0.5	0.7	-0.7	0.6	-0.6	-0.6	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.6	0.7	-0.2	0.2	0.2	-0.2
Total zone transitions, hab. session 1	0.1	0.2	0.6	0.7	-0.8	0.2	-0.2	-0.2	0.2
Total locomotion distance, hab. session 1	0.0	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.1	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.2	0.3	-0.4	-0.0	0.0	0.1	-0.0
Time in familiar zone, hab. session 2	2.0	2.1	3.3	1.8	-1.6	1.4	-1.3	-1.3	1.3
Time in novel zone, hab. session 2	1.9	1.9	2.9	-1.7	1.5	-1.3	1.3	1.2	-1.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	-0.1	0.0	-0.4	0.4	0.4	-0.4
Total locomotion distance, hab. session 2	0.6	0.8	1.1	-0.7	0.6	-1.0	1.0	1.0	-1.0
Locomotion velocity, hab. session 2	0.8	1.0	1.2	-0.9	0.8	-1.1	1.1	1.1	-1.1
Novel to familiar place preference ratio	2.3	2.6	2.7	-1.5	1.5	-1.6	1.6	1.6	-1.6
Novelty place preference	2.2	2.4	2.6	-1.5	1.4	-1.6	1.6	1.6	-1.6
Time in novel zone, NPP test	1.9	2.0	2.2	-1.3	1.3	-1.5	1.5	1.5	-1.5
Total zone transitions, NPP test	0.7	1.1	1.1	1.0	-1.0	1.1	-1.1	-1.1	1.0
Total locomotion distance, NPP test	0.1	0.1	0.2	0.3	-0.3	0.4	-0.4	-0.4	0.4
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.0	0.1	0.1	-0.1	-0.1	0.1
Intraocular pressure	0.6	0.9	1.2	-0.6	0.5	-1.1	1.1	1.1	-1.1
Delta distance traveled before/after self-admin	0.0	0.0	0.2	-0.2	0.4	0.1	-0.1	-0.1	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	0.2	0.0	0.4	-0.4	-0.4	0.3
Parametrial fat weight	5.0	11.8	14.8	-2.6	2.5	-3.8	3.8	3.8	-3.8
Pavlov. Cond. lever latency	0.2	0.3	0.4	-0.4	0.3	-0.6	0.6	0.6	-0.6
Pavlov. Cond. magazine entry latency	1.0	1.2	1.5	1.2	-1.1	1.1	-1.1	-1.1	1.0
Pavlov. Cond. change in total contacts	0.9	1.0	1.4	-1.1	1.2	-0.9	0.9	0.9	-0.9
Pavlov. Cond. index score	1.1	1.4	1.6	1.2	-1.0	1.2	-1.3	-1.2	1.1
Pavlov. Cond. latency score	1.0	1.3	1.5	1.1	-1.0	1.2	-1.2	-1.2	1.1
Pavlov. Cond. lever contacts	0.6	0.7	0.9	0.8	-0.6	0.9	-1.0	-0.9	0.9
Pavlov. Cond. magazine entry number	0.7	0.9	1.2	-1.1	1.0	-1.0	1.0	0.9	-0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	0.2	-0.2	0.6	-0.6	-0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	2.0	1.3	-1.2	1.4	-1.4	-1.4	1.3
Pavlov. Cond. response bias	0.4	0.5	0.7	0.6	-0.5	0.8	-0.8	-0.8	0.7
Pavlov. Cond. lever latency	0.6	0.9	2.4	-1.5	1.6	-0.5	0.5	0.3	-0.2
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.2	0.1	-0.0	0.0	-0.0	-0.1
Pavlov. Cond. change in total contacts	0.3	0.4	1.1	1.0	-1.1	0.3	-0.3	-0.2	0.3
Pavlov. Cond. index score	0.4	0.5	1.2	1.0	-1.1	0.4	-0.4	-0.4	0.3
Pavlov. Cond. latency score	0.5	0.7	1.5	1.1	-1.2	0.7	-0.6	-0.6	0.5
Pavlov. Cond. lever contacts	0.8	1.2	2.9	1.6	-1.7	0.7	-0.7	-0.6	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.0	0.1	0.3	-0.3	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	-0.4	0.2	-0.2	-0.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	1.3	1.1	-1.2	0.5	-0.5	-0.5	0.4
Pavlov. Cond. response bias	0.3	0.4	1.1	1.0	-1.0	0.2	-0.2	-0.1	0.0
Time in closed arm before self-admin	0.7	0.8	1.1	0.8	-0.8	0.9	-1.0	-1.0	1.1
Time in closed arm after self-admin	4.6	4.9	5.5	2.3	-2.3	2.2	-2.2	-2.2	2.1
Time in open arm before self-admin	0.1	0.1	0.1	0.2	-0.3	0.3	-0.3	-0.3	0.2
Time in open arm after self-admin	3.3	3.6	4.0	-1.7	1.7	-2.0	2.0	2.0	-2.0
Bone: periosteal estimation	0.1	0.3	0.6	-0.8	0.6	-0.5	0.5	0.4	-0.4
Bone: periosteal perimeter	0.8	1.5	2.4	-1.5	1.2	-1.1	1.1	1.1	-1.0
Bone: post-yield work	0.1	0.1	0.2	-0.4	0.3	-0.3	0.3	0.3	-0.3
Progressive ratio test 1 active lever presses	1.3	1.6	2.7	-1.6	1.5	-1.1	1.1	1.0	-1.0
Progressive ratio test 1 breakpoint	1.3	1.6	2.6	-1.6	1.5	-1.1	1.1	1.1	-1.1
Progressive ratio test 1 inactive lever presses	3.0	4.4	5.5	-2.4	2.2	-2.0	2.0	2.0	-1.9
Progressive ratio test 2 active lever presses	2.7	3.2	4.5	-2.1	2.0	-1.6	1.6	1.6	-1.6
Progressive ratio test 2 breakpoint	2.6	3.0	4.1	-2.0	1.9	-1.6	1.6	1.6	-1.6
Progressive ratio test 2 inactive lever presses	3.9	6.3	7.4	-2.7	2.5	-2.5	2.5	2.4	-2.5
Incentive Sensitization - Responses	1.8	2.5	3.3	-1.8	1.7	-1.5	1.5	1.5	-1.5
Incentive Sensitization - Breakpoint	1.8	2.3	3.0	-1.7	1.6	-1.4	1.4	1.4	-1.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.6	0.7	-0.3	0.3	0.2	-0.3
Progressive ratio	0.2	0.3	0.8	-0.8	0.9	-0.2	0.2	0.1	-0.2
Food seeking constrained by brief footshock	1.3	1.6	4.5	-2.1	2.0	-0.6	0.6	0.5	-0.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.2	-0.3	0.3	-0.3	-0.3	0.4
Retroperitoneal fat weight	1.1	4.7	6.0	-1.6	1.5	-2.4	2.4	2.5	-2.4
Reaction time number correct	0.0	0.1	0.2	0.4	-0.4	-0.1	0.1	0.2	-0.1
Reaction time mean minus median	0.3	0.9	1.5	-0.6	0.5	-1.0	1.0	1.0	-1.2
Reaction time mean minus median AUC	0.2	0.5	0.7	-0.7	0.7	-0.7	0.7	0.7	-0.9
Reaction time num false alarms	0.2	0.2	0.7	-0.8	0.8	-0.1	0.1	-0.0	-0.0
Reaction time num false alarms AUC	0.1	0.2	0.4	-0.6	0.6	0.3	-0.3	-0.4	0.3
Reaction time trials correct on left	0.0	0.1	0.2	0.4	-0.4	-0.1	0.1	0.2	-0.1
Reaction time trials on left	0.0	0.1	0.2	0.4	-0.5	-0.1	0.1	0.1	-0.1
Reaction time mean	0.1	0.1	0.2	-0.1	0.2	-0.4	0.4	0.4	-0.5
Reaction time mean AUC	0.0	0.0	0.0	0.1	-0.1	-0.1	0.1	0.1	-0.2
Median of all reaction times	0.0	0.0	0.0	0.2	-0.1	-0.0	0.0	0.0	-0.1
Reaction time omissions	0.2	0.3	0.5	0.6	-0.7	0.5	-0.5	-0.5	0.4
Reaction time false alarm rate	0.2	0.3	0.7	-0.8	0.8	0.3	-0.3	-0.5	0.4
Reaction time premature initiation rate	5.3	7.4	8.5	2.9	-2.8	2.7	-2.7	-2.6	2.6
Reaction time premature initiations	2.7	4.9	6.5	2.5	-2.4	2.1	-2.1	-2.0	2.0
Std. dev. reaction times	0.5	0.9	1.5	-0.7	0.7	-1.0	1.0	1.0	-1.2
Reaction time trials completed	0.0	0.1	0.2	0.4	-0.5	-0.1	0.1	0.1	-0.1
Reaction time trials AUC	0.0	0.0	0.1	0.3	-0.4	-0.1	0.1	0.1	-0.1
Run reversals in cocaine runway, females	0.0	0.0	0.0	0.0	-0.2	0.0	-0.0	-0.0	-0.1
Run reversals in cocaine runway, males	0.0	0.0	0.0	-0.2	0.1	-0.0	0.0	0.0	0.0
Latency to leave start box in cocaine runway	0.1	0.1	0.1	-0.0	-0.1	0.3	-0.3	-0.4	0.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	-0.3	0.1	0.3	-0.3	-0.4	0.4
Latency to leave start box in cocaine runway, M	0.0	0.0	0.0	0.1	-0.2	-0.0	0.0	0.0	-0.1
Std. dev. time between licks in bursts	0.4	0.6	1.3	1.1	-1.1	0.5	-0.5	-0.5	0.5
Total sessions with >9 infusions	0.6	0.7	1.0	0.4	-0.5	0.9	-1.0	-1.0	0.9
Short access day 1 total inactive lever presses	1.4	1.8	3.1	-1.8	1.7	-1.2	1.2	1.1	-1.0
Short access day 10 total inactive lever presses	0.1	0.3	0.4	0.6	-0.7	0.5	-0.5	-0.5	0.5
Short access day 1 total infusions	0.4	0.6	0.8	0.4	-0.5	0.9	-0.9	-0.9	0.9
Short access day 10 total infusions	0.1	0.1	0.1	-0.3	0.1	0.3	-0.3	-0.4	0.3
Short access total infusions	0.1	0.1	0.3	-0.6	0.3	0.1	-0.1	-0.2	0.2
Short access day 1 locomotion	1.6	2.0	2.6	1.0	-1.0	1.6	-1.6	-1.6	1.6
Short access day 10 total locomotion	1.7	3.2	3.6	1.6	-1.6	1.9	-1.9	-1.9	1.9
Short access total locomotion	3.5	4.3	4.7	1.9	-1.9	2.1	-2.1	-2.1	2.2
One hour access (0.3 mA shock)	2.2	2.5	3.2	-1.8	1.7	-1.5	1.5	1.5	-1.5
Compulsive drug intake	2.8	3.3	4.7	2.1	-2.2	1.7	-1.7	-1.6	1.6
One hour access (shock baseline)	4.0	6.1	8.0	-2.8	2.8	-2.3	2.3	2.2	-2.3
Social response proportion	1.2	1.4	2.0	-0.7	0.6	-1.4	1.4	1.4	-1.4
Social responses	1.5	2.0	2.7	-0.9	0.9	-1.6	1.6	1.7	-1.6
Social time	0.1	0.1	0.1	0.2	-0.2	-0.3	0.3	0.4	-0.4
Soleus weight	0.2	0.4	1.5	-1.2	1.1	-0.0	0.0	-0.1	0.2
Bone: stiffness	0.1	0.2	0.4	0.5	-0.6	0.3	-0.3	-0.3	0.3
Tibialis anterior weight	1.1	3.8	6.0	-2.5	2.3	-1.7	1.7	1.6	-1.6
Time to tail flick, vehicle, before self-admin	0.0	0.1	0.2	-0.4	0.4	0.0	-0.0	-0.0	0.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.2	-0.1	0.3	-0.3	-0.3	0.3
Time to tail flick, test, before self-admin	0.8	0.8	1.1	0.8	-0.8	1.0	-1.0	-0.9	1.0
Time to tail flick, test, after self-admin	0.5	0.5	1.1	-1.0	1.0	-0.5	0.5	0.4	-0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.4	-0.4	0.1	-0.1	-0.1	0.1
Delta time to tail flick, test, before/after SA	1.4	1.4	1.6	-1.1	1.1	-1.3	1.3	1.2	-1.2
Tibia length	0.6	1.8	2.6	0.7	-0.8	1.5	-1.5	-1.6	1.6
Ambulatory time before self-admin	0.1	0.1	0.2	-0.5	0.3	0.2	-0.3	-0.3	0.4
Ambulatory time after self-admin	0.2	0.2	0.4	-0.1	0.1	0.6	-0.6	-0.6	0.6
Bone: tissue strength	0.0	0.0	0.2	0.4	-0.1	0.1	-0.1	-0.1	0.2
Total heroin consumption	0.2	0.3	0.4	0.6	-0.7	0.5	-0.5	-0.4	0.5
Bone: trabecular number	0.7	1.1	1.5	0.8	-0.9	1.1	-1.1	-1.2	1.2
Bone: trabecular spacing	1.6	2.1	2.2	-1.5	1.4	-1.5	1.4	1.4	-1.4
Bone: trabecular thickness	2.6	3.2	3.5	1.7	-1.5	1.9	-1.9	-1.9	1.9
Bone: trabecular tissue density	0.3	0.4	0.7	-0.3	0.4	-0.7	0.7	0.8	-0.9
Water consumed over 24 hours	0.5	0.6	1.0	-0.2	0.2	-0.9	0.9	1.0	-0.9
Number of responses in last shaping day	0.0	0.0	0.0	0.1	-0.1	-0.1	0.0	0.1	-0.1