Hub : Genes

Asb8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Asb8 0.04 0.03 3.8e-04 0.02 0.02 0.02 0.02 1.2e-03 8.8e-04 5.6e-03 9.9e-04
2 Brain gene expression Asb8 0.04 0.03 1.5e-04 0.04 0.03 0.03 0.03 1.6e-04 5.0e-04 1.5e-03 6.6e-04
3 Liver gene expression Asb8 0.06 0.05 3.5e-07 0.05 0.05 0.04 0.05 1.7e-06 2.0e-06 1.5e-05 2.5e-06
4 PL mRNA stability Asb8 0.03 0.02 2.4e-05 0.04 0.04 0.04 0.04 6.5e-05 2.6e-05 5.4e-05 5.3e-05
5 NAcc gene expression Asb8 0.06 0.04 1.2e-08 0.07 0.06 0.06 0.06 4.0e-08 1.1e-07 4.9e-07 4.8e-08
6 Brain mRNA stability Asb8 0.07 0.05 1.6e-09 0.11 0.09 0.1 0.1 2.1e-10 1.1e-08 7.6e-10 1.3e-09
7 Adipose mRNA stability Asb8 0.14 0.08 0.0e+00 0.18 0.16 0.18 0.18 8.3e-20 8.0e-18 2.4e-19 3.2e-19
8 PL intron excision ratio chr7_129268956_129271550 0.03 0.02 1.7e-03 0.03 0.02 0.03 0.02 7.1e-04 1.5e-03 8.0e-04 1.8e-03
9 pVTA mRNA stability Asb8 0.11 0.07 1.1e-05 0.11 0.1 0.1 0.07 1.3e-05 3.5e-05 3.5e-05 4.4e-04
10 PL intron excision ratio chr7_129267287_129268793 0.06 0.04 4.2e-03 -0 0.01 0.02 0.01 3.8e-01 4.9e-02 4.9e-03 9.3e-03
11 Liver alternative TSS XM_017594889.2 0.03 0.03 9.5e-03 0 0.01 0.01 0.01 7.9e-02 2.8e-02 2.6e-02 5.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density8.314.017.2-4.1-4.04.0-3.84.14.14.1-4.13.23.2-1.1
Area under the delay curve1.41.52.2-1.5-1.01.0-1.21.31.31.4-1.10.91.4-1.0
BMI with tail4.314.118.8-4.3-4.24.2-4.14.14.23.7-3.83.42.9-1.0
BMI without tail0.10.20.4-0.6-0.60.6-0.40.60.60.4-0.3-0.10.20.5
Body weight6.226.033.4-5.8-5.65.6-5.65.65.85.4-5.24.93.3-1.1
Weight adjusted by age2.32.63.5-1.5-1.81.8-1.81.71.81.9-1.81.7-0.10.9
Bone surface9.817.221.2-4.6-4.54.5-4.44.64.54.6-4.63.83.0-0.7
Bone volume7.212.215.3-3.8-3.73.7-3.73.93.93.9-3.93.12.7-0.7
Breakpoint value in progressive ratio session0.20.20.4-0.3-0.50.5-0.40.30.30.2-0.50.60.6-0.5
Number of licking bursts0.60.73.50.70.1-0.10.3-0.2-0.3-0.20.30.5-1.81.9
Context. condit. distance diff. score0.30.40.6-0.6-0.70.7-0.70.70.60.8-0.70.60.10.2
Locomotion velocity, session 11.01.11.91.01.4-1.40.9-0.9-1.1-0.91.1-0.8-1.00.4
Locomotion distance, session 12.93.76.31.72.5-2.52.0-1.8-2.0-1.82.0-2.50.1-1.0
Locomotion velocity, session 20.40.51.20.51.1-1.10.6-0.4-0.7-0.30.6-0.70.4-1.0
Locomotion distance, session 22.53.45.81.62.4-2.41.9-1.8-1.9-1.81.9-2.30.1-1.0
Locomotion velocity, session 33.33.86.11.82.5-2.52.0-2.0-2.1-2.02.1-2.3-0.3-0.8
Locomotion distance, session 34.54.97.32.32.7-2.72.4-2.3-2.4-2.32.3-2.6-0.6-0.5
Stereotopy head waving bouts, day 30.70.91.8-0.9-0.90.9-1.10.81.10.9-1.21.30.10.1
Stereotopy head waving duration, day 30.20.30.7-0.4-0.40.4-0.60.50.60.5-0.70.8-0.00.1
Locomotion velocity, session 70.10.10.30.20.5-0.50.2-0.2-0.2-0.20.3-0.4-0.50.6
Locomotion distance, session 71.11.41.61.21.2-1.21.2-1.2-1.1-1.21.3-1.2-1.21.0
Stereotopy head waving bouts, day 70.70.81.7-0.8-1.01.0-1.10.91.00.8-1.11.3-0.10.1
Stereotopy head waving duration, day 71.01.22.1-1.1-1.21.2-1.31.11.21.1-1.21.4-0.0-0.0
Locomotion velocity, session 80.10.10.6-0.30.2-0.2-0.20.20.00.2-0.1-0.00.4-0.8
Locomotion distance, session 81.11.63.31.11.5-1.51.3-1.3-1.4-1.21.3-1.80.2-0.9
Degree of sensitization distance0.80.81.4-0.8-1.21.2-0.90.80.90.8-0.80.9-0.31.1
Degree of sensitization stereotypy0.30.30.8-0.4-0.50.5-0.70.50.40.5-0.50.9-0.60.4
Conditioned locomotion0.20.21.10.30.0-0.0-0.10.10.1-0.1-0.10.6-1.10.9
Cocaine response after cond. corrected0.70.84.2-0.60.2-0.2-0.00.00.0-0.10.1-0.71.9-2.0
Cocaine response after cond. not corrected0.91.02.50.50.9-0.90.9-0.9-0.9-1.00.9-1.21.1-1.6
Cocaine response before conditioning4.14.98.42.92.0-2.02.6-2.5-2.5-2.42.3-1.5-2.11.2
Saline control response0.00.10.20.2-0.40.40.10.10.10.1-0.20.2-0.10.3
Bone: connectivity density6.09.511.8-3.4-3.33.3-3.23.33.33.3-3.42.53.0-1.3
Bone: cortical apparent density0.30.40.80.90.4-0.40.7-0.7-0.7-0.70.7-0.4-0.70.1
Bone: cortical area9.013.517.2-4.0-4.04.0-4.04.14.14.1-4.03.62.1-0.2
Bone: cortical porosity1.71.93.31.61.2-1.21.4-1.2-1.3-1.31.3-0.8-1.81.8
Bone: cortical porosity2.22.43.61.81.4-1.41.6-1.5-1.5-1.61.5-1.0-1.91.8
Bone: cortical thickness3.86.28.3-2.8-2.52.5-2.72.92.82.8-2.82.21.9-0.7
Bone: cortical thickness0.30.40.5-0.7-0.70.7-0.60.60.70.7-0.60.50.7-0.3
Bone: cortical tissue density0.40.61.11.00.5-0.50.9-0.8-0.8-0.90.8-0.5-0.80.2
Condit. Reinf. active minus inactive responses0.30.41.70.10.6-0.60.3-0.2-0.3-0.20.2-0.80.9-1.3
Condit. Reinf. active-inactive response ratio0.40.52.0-0.6-0.10.1-0.30.40.40.4-0.5-0.11.4-1.4
Condit. Reinf. active responses0.60.71.40.71.2-1.20.8-0.8-0.8-0.80.8-1.10.4-0.8
Condit. Reinf. inactive responses2.42.83.61.91.8-1.81.8-1.9-1.8-1.81.8-1.3-1.51.0
Incentive salience index mean0.20.20.7-0.30.0-0.0-0.20.40.30.4-0.3-0.10.9-0.8
Condit. Reinf. lever presses0.30.40.7-0.7-0.30.3-0.60.80.80.8-0.70.40.7-0.4
Condit. Reinf. active minus inactive responses0.10.21.00.2-0.00.00.2-0.2-0.2-0.00.30.0-0.81.0
Condit. Reinf. active-inactive response ratio0.20.20.40.50.5-0.50.5-0.6-0.6-0.40.6-0.6-0.30.2
Condit. Reinf. active responses0.40.52.00.70.2-0.20.6-0.6-0.6-0.50.7-0.2-1.21.4
Condit. Reinf. inactive responses0.91.12.51.30.6-0.61.0-1.1-1.1-1.01.0-0.4-1.61.5
Condit. Reinf. lever presses0.10.10.60.2-0.30.30.1-0.1-0.2-0.10.10.2-0.40.8
Condit. Reinf. lever reinforcers received0.60.91.91.00.5-0.50.9-0.9-1.0-0.81.0-0.6-1.21.4
Conditioned reinforcement - actives1.21.21.71.31.0-1.01.2-1.3-1.2-1.31.2-1.0-0.80.3
Conditioned reinforcement - inactives1.21.42.01.11.3-1.31.2-1.3-1.2-1.31.3-1.4-0.2-0.3
Conditioned locomotion0.40.51.60.80.3-0.30.6-0.6-0.6-0.60.6-0.3-1.31.1
Patch foraging indifference point 0 sec1.72.73.31.61.7-1.71.7-1.5-1.8-1.41.8-1.6-1.61.6
Patch foraging indifference point AUC0.20.30.90.60.2-0.20.4-0.4-0.5-0.40.5-0.6-1.00.6
Delay disc. indifference point, 0s delay1.01.12.0-1.3-1.01.0-1.31.31.41.1-1.00.80.20.3
Delay disc. indifference point, 16s delay1.41.42.4-1.3-1.21.2-1.31.41.41.6-1.21.10.6-0.1
Delay disc. indifference point, 2s delay0.91.01.3-1.1-1.11.1-1.11.11.11.0-1.11.00.6-0.3
Delay disc. indifference point, 24s delay1.41.42.1-1.2-1.31.3-1.31.31.31.5-1.21.20.5-0.0
Delay disc. indifference point, 4s delay0.60.62.2-0.9-0.40.4-0.60.60.70.7-0.50.41.5-1.1
Delay disc. indifference point, 8s delay3.43.54.8-2.2-1.71.7-1.92.02.02.0-1.81.62.0-1.4
Indifference point function ln k3.04.25.8-2.3-2.02.0-2.32.32.22.4-2.22.20.61.0
Indifference point function log k3.04.25.8-2.3-2.02.0-2.32.32.22.4-2.22.20.61.0
Patch foraging total patch changes 0 sec1.72.83.41.71.7-1.71.7-1.5-1.8-1.41.8-1.5-1.81.8
Patch foraging total patch changes 12 sec1.31.72.41.51.2-1.21.4-1.4-1.5-1.31.3-1.3-1.30.3
Patch foraging total patch changes 18 sec3.84.97.72.42.0-2.02.2-2.1-2.2-1.92.4-2.1-2.82.3
Patch foraging total patch changes 24 sec1.72.04.71.51.3-1.31.3-1.2-1.4-1.11.4-1.1-2.21.6
Patch foraging total patch changes 6 sec2.02.94.01.91.6-1.61.9-1.8-2.0-1.71.8-1.8-1.40.9
Patch foraging time to switch 0 sec2.23.45.32.21.8-1.82.1-2.3-2.1-2.31.8-1.4-1.0-0.0
Patch foraging water rate 0 sec2.84.67.2-2.6-2.02.0-2.62.72.52.6-2.21.70.70.5
Patch foraging water rate 12 sec2.84.45.9-2.3-2.12.1-2.42.42.42.4-2.22.10.90.0
Patch foraging water rate 18 sec0.40.50.9-0.9-0.70.7-0.90.80.80.8-0.70.60.30.4
Patch foraging water rate 24 sec2.43.44.5-1.8-1.91.9-2.12.12.02.1-2.12.00.7-0.4
Patch foraging water rate 6 sec3.24.66.6-2.5-2.12.1-2.52.62.42.4-2.32.21.2-0.5
Seeking ratio, delayed vs. immediate footshock0.81.03.9-0.9-0.50.5-0.50.50.70.2-0.70.52.0-1.9
Distance traveled before self-admin1.31.42.41.21.2-1.21.0-1.1-1.0-1.11.1-0.9-1.51.3
Distance traveled after self-admin0.20.20.50.30.7-0.70.4-0.4-0.3-0.40.4-0.50.2-0.1
Extensor digitorum longus weight4.417.423.1-4.7-4.64.6-4.84.64.64.6-4.54.31.50.8
Bone: elastic displacement4.44.96.52.52.6-2.62.4-2.1-2.4-2.22.4-2.1-1.81.2
Bone: elastic work0.10.10.40.30.4-0.40.30.0-0.2-0.10.2-0.0-0.50.6
Bone: endosteal estimation6.013.217.4-3.8-4.24.2-4.03.93.94.0-3.94.01.30.5
Bone: endosteal perimeter6.112.617.2-3.7-4.24.2-3.93.83.83.8-3.83.91.50.2
Epididymis fat weight0.30.61.4-1.2-0.70.7-0.91.01.10.9-0.40.10.7-0.2
Delta time in closed arm before/after self-admin0.70.72.9-0.7-0.40.4-0.30.40.40.3-0.20.41.7-1.7
Delta time in open arm before/after self-admin3.83.74.62.12.1-2.12.0-1.9-2.0-1.91.9-2.0-1.71.1
Diff in mean of infusions in LGA sessions1.21.32.0-1.3-1.11.1-1.21.21.11.0-1.21.11.4-1.0
Delay discount exponential model param1.21.32.01.41.0-1.01.1-1.2-1.2-1.31.0-0.9-1.40.9
Extinction: sum of active levers before priming0.30.30.4-0.5-0.40.4-0.60.60.60.5-0.60.3-0.10.4
Active lever presses in extinction session 60.50.51.2-0.7-0.50.5-0.60.80.60.6-0.70.71.1-0.9
Bone: final force8.613.917.9-4.2-3.93.9-4.14.24.14.2-4.13.42.7-0.7
Bone: final moment8.714.118.3-4.3-3.93.9-4.14.34.14.2-4.13.42.8-0.8
Food consumed during 24 hour testing period1.51.83.3-1.5-1.41.4-1.31.31.31.2-1.50.91.8-1.0
Glucose0.20.30.6-0.3-0.80.8-0.50.40.50.4-0.50.40.2-0.5
Heart weight0.40.53.8-0.2-0.10.1-0.0-0.0-0.0-0.2-0.20.31.3-1.9
Delay discount hyperbolic model param1.11.21.81.30.9-0.91.1-1.2-1.2-1.21.0-0.8-1.30.9
Intermittent access intake day 1-15 change0.80.81.20.90.8-0.81.0-1.0-1.0-1.11.0-0.80.1-0.5
Intermittent access intake escalation0.50.50.80.60.6-0.60.9-0.8-0.8-0.90.9-0.70.4-0.7
Intermittent access intake escalation 20.80.81.20.90.9-0.91.1-1.0-1.0-1.11.1-0.90.1-0.4
Intermitt. access day 1 inactive lever presses3.94.28.02.31.7-1.71.9-2.0-2.0-1.82.0-1.7-2.82.3
Intermitt. access day 15 inactive lever presses1.21.31.81.21.1-1.11.1-1.0-1.0-1.01.2-1.2-1.31.0
Intermitt. access escalation Index0.20.20.50.60.2-0.20.5-0.5-0.6-0.40.4-0.2-0.70.5
Intermittent access day 1 total infusions1.01.21.51.21.2-1.21.2-1.2-1.2-1.21.1-1.1-0.2-0.5
Intermittent access day 15 total infusions1.71.92.71.61.4-1.41.6-1.6-1.6-1.61.5-1.3-0.6-0.0
Intermittent access terminal intake (last 3 days)2.02.12.81.61.6-1.61.7-1.6-1.6-1.61.7-1.5-0.60.1
Intermittent access total infusions1.82.02.71.61.6-1.61.6-1.6-1.6-1.61.5-1.4-0.70.1
Intermittent access day 1 locomotion1.01.12.31.20.9-0.91.0-1.0-0.9-0.91.0-0.8-1.51.0
Intermittent access day 15 total locomotion1.11.23.21.30.9-0.91.0-1.0-0.9-0.91.2-0.7-1.81.2
Intermittent access total locomotion3.03.47.22.11.6-1.61.7-1.7-1.6-1.61.9-1.4-2.71.9
Intermittent access standard deviation0.40.40.70.70.6-0.60.7-0.7-0.8-0.90.6-0.50.1-0.4
Left kidney weight0.61.66.0-1.5-0.60.6-1.01.01.00.7-1.00.62.5-1.9
Right kidney weight2.46.88.9-3.0-2.82.8-3.02.92.92.7-2.82.61.6-0.5
Cocaine induced anxiety1.11.21.9-0.9-1.41.4-1.11.01.01.2-1.21.3-0.10.8
Post-drug Anxiety3.94.36.2-2.0-2.52.5-2.22.12.12.1-2.42.30.80.2
Baseline Anxiety1.11.21.6-1.3-0.80.8-1.11.21.21.1-1.10.81.2-1.0
Tail length0.00.10.30.40.1-0.10.3-0.2-0.3-0.20.3-0.4-0.60.4
Length with tail1.86.68.2-2.8-2.82.8-2.82.82.92.8-2.62.51.7-0.9
Length without tail6.915.219.3-4.4-4.04.0-4.24.04.14.0-4.03.93.5-2.3
Times rat made contact with spout0.00.10.1-0.40.2-0.2-0.10.10.10.10.0-0.30.40.3
Lifetime Intake1.41.62.21.41.5-1.51.4-1.4-1.3-1.41.4-1.3-0.5-0.1
Liver weight, left1.82.94.3-1.8-2.12.1-1.81.71.91.7-1.91.61.0-0.0
Liver weight, right1.62.63.5-1.8-1.91.9-1.81.81.81.8-1.61.40.70.2
Locomotor activity0.71.21.61.21.2-1.21.1-1.0-1.1-1.01.0-1.0-1.10.7
Locomotor testing distance2.13.54.72.22.1-2.12.1-2.0-2.0-1.82.1-1.6-1.50.5
Locomotor testing rearing1.62.54.72.21.5-1.51.9-1.6-1.8-1.51.8-0.8-1.50.2
Locomotion in novel chamber0.50.60.9-0.9-0.80.8-1.00.90.80.8-0.80.70.10.4
Locomotion in novel chamber post-restriction0.20.20.5-0.6-0.20.2-0.60.70.60.5-0.10.1-0.00.0
Fecal boli incidents, locomotor time 12.12.36.40.41.8-1.81.1-0.9-1.0-1.11.1-1.72.0-2.5
Change in fecal boli incidents, locomotor task0.90.81.2-0.8-0.90.9-1.01.00.91.0-1.10.7-0.21.0
Time >=10cm from walls, locomotor time 10.70.71.8-1.0-0.50.5-0.70.80.80.6-0.50.31.3-1.3
Bouts of movement, locomotor time 10.40.41.7-0.60.3-0.3-0.30.50.60.4-0.2-0.21.1-1.3
Total resting periods, locomotor time 10.30.41.5-0.10.8-0.80.2-0.0-0.0-0.20.4-0.70.9-1.2
Rest time, locomotor task time 10.40.41.60.10.9-0.90.3-0.2-0.2-0.50.4-0.80.8-1.2
Distance moved, locomotor task time 10.30.31.10.5-0.50.50.3-0.4-0.4-0.40.10.4-0.91.0
Vertical activity count, locomotor time 11.41.52.2-1.3-1.51.5-1.11.01.01.1-1.11.31.4-1.0
Time >=10cm from walls, locomotor time 20.40.41.10.51.0-1.00.5-0.5-0.5-0.60.6-1.0-0.1-0.1
Bouts of movement, locomotor time 22.42.63.8-1.6-1.71.7-1.81.91.82.0-1.41.5-0.31.2
Total resting periods, locomotor time 22.72.84.1-1.7-1.91.9-1.91.91.82.0-1.61.6-0.11.0
Rest time, locomotor task time 20.30.41.4-0.6-0.30.3-0.40.50.50.6-0.30.20.9-1.2
Distance moved, locomotor task time 20.40.51.20.70.4-0.40.6-0.7-0.6-0.80.5-0.3-0.91.1
Vertical activity count, locomotor time 20.10.10.4-0.4-0.20.2-0.40.30.30.3-0.10.5-0.30.6
Light reinforcement 12.44.47.02.61.8-1.82.3-2.3-2.2-2.02.1-1.5-2.61.6
Light reinforcement 20.60.91.11.11.0-1.01.0-1.1-0.9-1.00.7-0.8-0.80.7
Bone: marrow area6.012.917.0-3.8-4.14.1-4.03.93.83.9-3.94.01.20.6
Bone: maximum diameter3.97.29.3-2.9-3.13.1-3.03.02.93.0-2.92.90.90.5
Bone: maximum force11.319.524.9-4.8-4.94.9-4.85.04.85.0-4.84.32.5-0.2
Bone: maximum moment11.319.525.1-4.8-4.94.9-4.85.04.85.0-4.84.32.6-0.3
Mean time between licks in bursts0.30.40.60.70.7-0.70.7-0.6-0.6-0.80.5-0.4-0.60.8
Mean num. licks in bursts0.70.83.6-0.50.5-0.50.1-0.1-0.1-0.20.1-1.11.9-1.8
Cd content in liver0.30.30.40.50.6-0.60.6-0.6-0.6-0.60.5-0.6-0.20.0
Co content in liver0.00.10.20.30.4-0.40.3-0.1-0.1-0.10.10.0-0.10.0
Cu content in liver1.01.21.7-1.3-0.60.6-1.31.21.21.3-1.30.91.1-0.8
Fe content in liver0.00.10.10.30.2-0.20.3-0.2-0.3-0.20.2-0.4-0.0-0.1
K content in liver0.90.91.7-1.2-0.50.5-1.01.00.90.9-0.70.51.2-1.3
Mg content in liver0.10.10.9-0.30.2-0.2-0.10.10.2-0.1-0.1-0.10.7-0.9
Mn content in liver0.00.00.1-0.20.1-0.1-0.30.20.10.2-0.00.0-0.1-0.3
Na content in liver0.00.00.0-0.20.1-0.1-0.2-0.1-0.0-0.10.00.1-0.1-0.1
Rb content in liver0.00.10.20.20.2-0.20.2-0.1-0.1-0.20.4-0.3-0.3-0.1
Se content in liver0.40.40.60.50.7-0.70.7-0.7-0.6-0.70.7-0.70.3-0.8
Sr content in liver0.60.61.0-0.9-0.70.7-0.90.91.00.9-0.90.50.10.7
Zn content in liver1.01.11.70.91.3-1.30.8-0.9-0.9-0.91.1-0.9-1.30.9
Bone: minimum diameter7.614.218.2-3.8-4.34.3-4.14.14.14.1-4.14.21.7-0.2
Time in familiar zone, hab. session 10.40.40.70.30.8-0.80.5-0.6-0.6-0.60.6-0.80.5-0.8
Time in novel zone, hab. session 10.60.61.7-0.1-0.70.7-0.50.60.50.6-0.51.0-1.01.3
Total zone transitions, hab. session 10.30.50.80.70.9-0.90.6-0.5-0.6-0.40.6-0.7-0.70.7
Total locomotion distance, hab. session 10.00.00.10.10.3-0.30.2-0.1-0.1-0.00.1-0.40.2-0.1
Locomotion velocity, hab. session 10.00.00.00.00.1-0.10.1-0.00.00.0-0.0-0.20.2-0.2
Time in familiar zone, hab. session 20.20.20.7-0.5-0.30.3-0.30.50.40.5-0.40.10.8-0.3
Time in novel zone, hab. session 20.40.42.10.60.3-0.30.2-0.5-0.5-0.50.40.2-1.40.8
Total zone transitions, hab. session 20.30.41.10.21.0-1.00.4-0.3-0.5-0.20.5-1.10.4-0.4
Total locomotion distance, hab. session 20.30.31.10.20.7-0.70.4-0.4-0.4-0.30.4-1.00.6-0.6
Locomotion velocity, hab. session 20.20.30.8-0.00.6-0.60.2-0.2-0.2-0.10.2-0.90.8-0.7
Novel to familiar place preference ratio1.81.93.0-1.0-1.71.7-1.31.51.31.5-1.41.7-0.31.0
Novelty place preference1.41.52.4-0.7-1.51.5-1.01.31.11.3-1.11.5-0.61.2
Time in novel zone, NPP test1.31.32.1-0.5-1.51.5-0.91.20.91.2-1.01.5-0.91.4
Total zone transitions, NPP test1.11.63.40.91.8-1.81.2-1.1-1.2-1.11.2-1.90.4-0.8
Total locomotion distance, NPP test1.82.54.21.61.9-1.91.7-1.6-1.6-1.61.5-2.0-0.2-0.3
Locomotion velocity, NPP test1.01.42.91.11.5-1.51.3-1.1-1.1-1.11.1-1.70.3-0.6
Intraocular pressure7.210.014.83.83.1-3.13.6-3.5-3.4-3.53.3-3.2-2.31.0
Delta distance traveled before/after self-admin0.40.52.2-0.6-0.20.2-0.30.40.40.2-0.30.11.5-1.5
Delta ambulatory time before/after self-admin0.10.20.7-0.4-0.20.2-0.20.30.20.2-0.10.00.9-0.8
Parametrial fat weight1.42.86.21.42.0-2.01.7-1.7-1.7-1.71.9-2.5-0.4-0.4
Pavlov. Cond. lever latency0.00.00.10.1-0.00.00.0-0.2-0.2-0.20.20.0-0.3-0.0
Pavlov. Cond. magazine entry latency0.10.10.7-0.2-0.00.00.10.10.00.1-0.0-0.40.8-0.7
Pavlov. Cond. change in total contacts0.10.10.2-0.2-0.30.3-0.20.30.30.4-0.40.30.4-0.2
Pavlov. Cond. index score0.20.20.3-0.5-0.50.5-0.40.60.60.6-0.60.30.4-0.1
Pavlov. Cond. latency score0.10.20.3-0.4-0.40.4-0.30.50.50.5-0.50.20.5-0.1
Pavlov. Cond. lever contacts0.10.10.20.40.3-0.30.5-0.3-0.3-0.30.3-0.5-0.10.4
Pavlov. Cond. magazine entry number0.00.10.30.10.0-0.0-0.0-0.1-0.0-0.10.10.2-0.50.5
Pavlov. Cond. intertrial magazine entries0.60.81.40.61.2-1.20.8-1.0-0.7-0.90.7-0.90.4-1.1
Pavlov. Cond. lever-magazine prob. diff.0.50.60.8-0.8-0.70.7-0.80.90.90.9-0.90.60.8-0.4
Pavlov. Cond. response bias0.10.10.40.00.1-0.10.2-0.0-0.1-0.10.1-0.40.6-0.4
Pavlov. Cond. lever latency0.00.00.0-0.20.1-0.1-0.1-0.0-0.00.10.0-0.10.0-0.1
Pavlov. Cond. magazine entry latency0.70.81.3-0.7-1.11.1-0.80.90.90.9-1.01.00.5-0.2
Pavlov. Cond. change in total contacts1.52.03.2-1.3-1.81.8-1.31.51.51.4-1.61.51.2-0.2
Pavlov. Cond. index score0.40.51.0-0.5-1.01.0-0.60.80.80.7-0.80.80.4-0.1
Pavlov. Cond. latency score0.50.60.9-0.7-1.01.0-0.70.90.80.7-0.90.80.6-0.2
Pavlov. Cond. lever contacts0.10.10.20.50.1-0.10.5-0.3-0.3-0.40.3-0.3-0.0-0.1
Pavlov. Cond. magazine entry number1.82.23.41.31.9-1.91.5-1.6-1.6-1.61.6-1.8-0.60.1
Pavlov. Cond. intertrial magazine entries3.85.07.82.02.8-2.82.2-2.4-2.4-2.42.4-2.5-0.5-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.91.7-0.7-1.31.3-0.91.01.00.9-1.11.20.40.0
Pavlov. Cond. response bias0.00.00.10.3-0.20.20.2-0.1-0.1-0.2-0.00.1-0.00.1
Time in closed arm before self-admin1.41.62.6-0.8-1.61.6-1.21.01.11.3-1.41.6-0.51.2
Time in closed arm after self-admin0.50.51.0-0.7-1.01.0-0.70.60.70.7-0.70.90.4-0.1
Time in open arm before self-admin0.70.81.4-1.1-0.80.8-1.01.21.11.2-0.60.90.4-0.2
Time in open arm after self-admin0.30.30.60.50.8-0.80.5-0.4-0.5-0.40.5-0.5-0.60.5
Bone: periosteal estimation10.321.227.0-4.9-5.25.2-5.15.15.05.1-5.04.82.20.0
Bone: periosteal perimeter9.215.319.0-4.4-4.34.3-4.34.34.24.3-4.23.82.4-0.5
Bone: post-yield work6.38.611.8-3.0-3.43.4-3.33.13.13.2-3.13.30.80.2
Progressive ratio test 1 active lever presses3.03.14.22.02.0-2.01.9-1.8-1.8-1.81.9-1.7-1.40.4
Progressive ratio test 1 breakpoint2.72.83.71.91.9-1.91.8-1.7-1.7-1.61.8-1.6-1.40.4
Progressive ratio test 1 inactive lever presses2.52.73.81.81.7-1.71.7-1.7-1.7-1.51.9-1.6-1.60.8
Progressive ratio test 2 active lever presses1.61.72.31.51.3-1.31.4-1.3-1.3-1.31.4-1.1-1.50.9
Progressive ratio test 2 breakpoint2.12.43.21.81.6-1.61.6-1.5-1.5-1.51.6-1.4-1.71.1
Progressive ratio test 2 inactive lever presses2.32.73.71.91.5-1.51.8-1.8-1.8-1.71.7-1.4-1.71.2
Incentive Sensitization - Responses0.10.10.4-0.2-0.40.4-0.30.20.20.2-0.30.2-0.30.7
Incentive Sensitization - Breakpoint0.10.10.5-0.1-0.20.2-0.10.10.10.0-0.10.1-0.40.7
Sum of active levers in priming session hrs 5-60.10.10.30.40.3-0.30.4-0.5-0.4-0.60.3-0.20.0-0.1
Progressive ratio0.10.10.4-0.10.1-0.10.1-0.1-0.20.10.1-0.10.5-0.7
Food seeking constrained by brief footshock0.10.10.40.10.4-0.40.2-0.1-0.10.00.3-0.60.2-0.6
Seeking ratio, punishment vs. effort0.00.00.10.0-0.00.0-0.10.10.2-0.0-0.1-0.2-0.40.4
Retroperitoneal fat weight0.31.12.90.30.9-0.90.7-0.9-0.8-0.90.8-1.41.2-1.7
Reaction time number correct0.71.01.9-0.8-0.80.8-0.90.80.90.9-1.21.41.0-1.2
Reaction time mean minus median6.99.111.83.13.1-3.13.4-3.3-3.4-3.43.4-3.30.0-1.8
Reaction time mean minus median AUC5.26.78.72.72.6-2.62.9-2.8-2.9-2.92.9-2.70.2-2.0
Reaction time num false alarms1.62.23.31.61.6-1.61.7-1.7-1.8-1.71.6-1.3-0.4-0.7
Reaction time num false alarms AUC2.43.34.81.91.8-1.82.1-2.1-2.2-2.11.9-1.7-0.1-1.1
Reaction time trials correct on left0.71.01.9-0.8-0.80.8-0.90.80.90.9-1.21.41.0-1.2
Reaction time trials on left0.50.81.7-0.7-0.70.7-0.80.70.70.8-1.01.20.9-1.3
Reaction time mean0.71.04.40.80.7-0.70.9-0.7-0.7-0.90.9-1.01.0-2.1
Reaction time mean AUC0.70.94.90.50.5-0.50.7-0.5-0.5-0.70.6-0.91.2-2.2
Median of all reaction times0.30.42.5-0.2-0.30.3-0.10.40.40.2-0.2-0.11.1-1.6
Reaction time omissions8.411.414.23.63.7-3.73.8-3.7-3.7-3.73.7-3.7-0.8-1.4
Reaction time false alarm rate2.02.83.91.71.7-1.71.9-1.8-2.0-1.92.0-1.8-0.6-0.1
Reaction time premature initiation rate4.15.57.22.72.3-2.32.5-2.6-2.6-2.42.5-2.3-2.00.6
Reaction time premature initiations2.23.14.72.21.8-1.82.0-2.1-2.1-1.91.8-1.5-1.3-0.1
Std. dev. reaction times5.37.49.22.72.8-2.83.0-2.8-2.9-2.93.0-3.00.4-2.6
Reaction time trials completed0.50.81.7-0.7-0.70.7-0.80.70.70.8-1.01.20.9-1.3
Reaction time trials AUC0.91.32.2-1.0-1.01.0-1.11.01.01.1-1.31.51.1-1.2
Run reversals in cocaine runway, females0.10.10.30.5-0.20.20.3-0.4-0.2-0.30.30.1-0.60.4
Run reversals in cocaine runway, males1.31.31.71.21.3-1.31.1-1.2-1.2-1.11.2-1.2-1.00.5
Latency to leave start box in cocaine runway0.00.10.30.1-0.20.20.1-0.2-0.1-0.20.1-0.1-0.30.5
Latency to leave start box in cocaine runway, F1.82.02.81.61.2-1.21.4-1.5-1.4-1.51.5-1.2-1.71.3
Latency to leave start box in cocaine runway, M1.91.82.5-1.6-1.51.5-1.41.31.41.3-1.41.21.3-0.6
Std. dev. time between licks in bursts0.70.91.51.20.8-0.81.1-1.0-1.0-1.01.0-0.5-1.00.4
Total sessions with >9 infusions0.30.30.60.50.7-0.70.6-0.5-0.4-0.70.5-0.50.1-0.6
Short access day 1 total inactive lever presses0.80.91.21.01.1-1.11.0-1.0-1.0-1.11.0-0.8-0.70.3
Short access day 10 total inactive lever presses0.80.93.01.00.4-0.40.7-0.8-0.9-0.70.7-0.4-1.71.5
Short access day 1 total infusions0.10.10.3-0.30.2-0.2-0.20.30.30.1-0.10.10.5-0.6
Short access day 10 total infusions0.40.50.60.70.8-0.80.8-0.8-0.7-0.70.7-0.60.3-0.7
Short access total infusions0.10.10.20.30.5-0.50.4-0.3-0.3-0.40.3-0.20.1-0.4
Short access day 1 locomotion0.10.10.4-0.00.0-0.0-0.10.20.30.20.10.1-0.60.5
Short access day 10 total locomotion0.60.73.80.70.3-0.30.3-0.3-0.3-0.40.5-0.2-1.91.5
Short access total locomotion0.30.41.80.70.3-0.30.4-0.4-0.2-0.40.5-0.2-1.30.8
One hour access (0.3 mA shock)0.10.10.20.40.1-0.10.4-0.4-0.4-0.40.3-0.10.1-0.1
Compulsive drug intake0.60.60.8-0.9-0.80.8-0.80.80.70.7-0.90.70.9-0.4
One hour access (shock baseline)0.00.00.00.0-0.10.10.1-0.10.0-0.00.10.00.0-0.0
Social response proportion0.10.10.30.50.2-0.20.5-0.5-0.5-0.50.2-0.10.2-0.3
Social responses6.28.012.03.42.6-2.63.2-3.3-3.5-3.33.0-2.5-1.7-0.3
Social time0.30.31.30.30.2-0.20.5-0.4-0.3-0.40.0-0.51.1-1.1
Soleus weight0.51.62.5-1.5-1.51.5-1.61.31.41.3-1.31.1-0.10.8
Bone: stiffness13.721.727.9-5.1-5.35.3-5.15.15.15.1-5.04.52.6-0.2
Tibialis anterior weight1.75.77.8-2.5-2.82.8-2.72.52.52.5-2.32.6-0.21.5
Time to tail flick, vehicle, before self-admin1.01.01.51.11.2-1.21.2-1.1-1.2-1.10.8-1.2-0.2-0.3
Time to tail flick, vehicle, after self-admin0.40.41.8-0.0-0.50.5-0.30.20.30.2-0.30.7-1.01.4
Time to tail flick, test, before self-admin0.60.61.10.70.9-0.90.8-0.8-0.7-0.80.9-1.1-0.3-0.0
Time to tail flick, test, after self-admin0.10.10.3-0.4-0.50.5-0.40.10.30.2-0.20.40.10.1
Delta time to tail flick, vehicle, before/after SA0.40.40.7-0.5-0.80.8-0.70.60.70.5-0.60.8-0.10.5
Delta time to tail flick, test, before/after SA0.30.30.5-0.6-0.60.6-0.60.50.50.6-0.50.7-0.00.3
Tibia length6.518.326.5-4.3-5.15.1-4.54.54.74.6-4.74.51.90.2
Ambulatory time before self-admin3.94.04.92.22.1-2.12.0-2.1-2.0-2.12.0-1.8-2.11.4
Ambulatory time after self-admin1.51.62.01.41.4-1.41.3-1.4-1.3-1.31.3-1.2-1.10.8
Bone: tissue strength0.50.50.8-0.6-0.80.8-0.60.80.80.7-0.80.90.3-0.1
Total heroin consumption1.82.13.1-1.4-1.61.6-1.71.71.61.8-1.31.7-0.20.6
Bone: trabecular number5.07.810.3-3.1-3.03.0-2.72.92.93.0-3.02.03.2-1.6
Bone: trabecular spacing1.92.44.81.71.6-1.61.3-1.6-1.6-1.61.6-0.8-2.21.1
Bone: trabecular thickness0.20.20.80.20.3-0.30.5-0.2-0.2-0.10.3-0.60.9-0.9
Bone: trabecular tissue density0.20.21.00.60.2-0.20.3-0.1-0.3-0.10.40.1-1.00.9
Water consumed over 24 hours0.10.10.6-0.4-0.00.0-0.20.10.10.1-0.0-0.1-0.10.8
Number of responses in last shaping day0.40.40.8-0.4-0.60.6-0.60.70.70.7-0.40.9-0.50.7