Hub : Genes

Arl5c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc isoform ratio NM_001109046.2 0.13 0.1 3.9e-12 0.1 0.11 0.1 0.11 7.9e-12 1.8e-12 8.2e-12 2.3e-12
2 Brain mRNA stability Arl5c 0.07 0.07 7.2e-05 0.03 0.04 0.04 0.03 3.8e-04 1.3e-04 2.0e-04 4.6e-04
3 NAcc alternative polyA XM_039086633.1 0.04 0.04 4.2e-04 0.01 0.01 0.01 0.01 9.9e-03 2.1e-02 2.5e-02 5.3e-02
4 NAcc alternative polyA XM_039086634.1 0.06 0.06 6.4e-05 0.02 0.02 0.01 0.01 1.8e-03 3.2e-03 9.6e-03 8.7e-03
5 PL gene expression Arl5c 0.14 0.08 5.6e-17 0.15 0.15 0.14 0.14 1.2e-16 3.1e-16 1.0e-15 1.2e-15
6 NAcc alternative TSS NM_001109046.2 0.11 0.12 3.5e-06 0.06 0.05 0.05 0.05 4.7e-07 2.7e-06 1.7e-06 1.3e-06
7 Adipose mRNA stability Arl5c 0.03 0.03 2.1e-04 0.02 0.03 0.02 0.02 6.2e-03 2.2e-04 2.6e-03 3.5e-03
8 PL alternative TSS XM_039086634.1 0.04 0.03 2.2e-05 0.03 0.03 0.02 0.03 2.2e-04 2.1e-04 1.1e-03 6.9e-04
9 NAcc alternative TSS XM_039086633.1 0.05 0.03 8.6e-07 0.04 0.06 0.05 0.04 7.4e-06 4.9e-07 3.2e-06 6.0e-06
10 Brain alternative polyA XM_039086633.1 0.04 0.03 1.3e-03 0.03 0.03 0.02 0.02 1.6e-03 9.8e-04 2.5e-03 2.7e-03
11 Brain alternative polyA XM_039086634.1 0.04 0.03 1.2e-03 0.03 0.03 0.03 0.02 1.5e-03 9.8e-04 2.2e-03 2.6e-03
12 Adipose gene expression Arl5c 0.06 0.05 2.5e-08 0.07 0.07 0.07 0.07 1.6e-08 3.2e-08 1.9e-08 1.5e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density2.33.84.4-2.02.12.1-2.1-2.02.01.9-1.91.9-1.91.91.6
Area under the delay curve0.80.81.0-0.90.90.8-0.8-0.80.71.0-1.01.0-1.01.01.0
BMI with tail1.65.36.02.4-2.4-2.52.52.3-2.3-2.32.3-2.32.3-2.3-2.1
BMI without tail0.10.20.30.3-0.3-0.50.50.3-0.1-0.50.4-0.40.5-0.5-0.6
Body weight6.125.627.85.1-5.2-5.35.35.2-4.5-5.15.1-5.15.0-5.0-4.8
Weight adjusted by age0.20.20.60.5-0.4-0.50.50.3-0.7-0.40.4-0.40.4-0.4-0.4
Bone surface0.00.00.1-0.00.00.0-0.00.10.3-0.10.1-0.10.1-0.1-0.3
Bone volume0.10.20.3-0.40.50.5-0.5-0.40.60.3-0.30.3-0.30.30.0
Breakpoint value in progressive ratio session1.01.11.70.9-1.2-1.21.21.3-0.2-1.11.1-1.11.1-1.1-0.8
Number of licking bursts0.50.60.9-0.70.80.9-0.9-0.90.40.8-0.80.8-0.80.80.7
Context. condit. distance diff. score0.60.72.20.9-0.8-0.80.80.7-1.5-0.70.8-0.70.7-0.7-0.6
Locomotion velocity, session 10.80.81.10.8-0.8-0.90.90.9-0.4-1.00.9-1.01.0-1.0-1.1
Locomotion distance, session 13.84.85.62.1-2.2-2.32.32.4-1.3-2.32.2-2.32.3-2.3-2.3
Locomotion velocity, session 20.60.71.00.7-0.8-0.80.80.9-0.2-0.90.9-0.90.9-0.9-1.0
Locomotion distance, session 20.91.31.80.9-1.0-1.21.21.20.3-1.21.2-1.21.3-1.3-1.4
Locomotion velocity, session 30.10.20.30.3-0.4-0.40.40.5-0.1-0.40.4-0.40.4-0.4-0.3
Locomotion distance, session 30.60.60.70.7-0.7-0.80.80.7-0.6-0.80.8-0.80.8-0.8-0.9
Stereotopy head waving bouts, day 33.74.44.8-2.12.02.2-2.2-2.01.72.1-2.12.1-2.22.22.2
Stereotopy head waving duration, day 30.50.60.9-0.70.70.9-0.9-0.70.40.8-0.80.8-0.90.90.9
Locomotion velocity, session 70.80.91.11.0-1.0-1.01.00.9-1.0-0.90.9-0.90.9-0.9-0.7
Locomotion distance, session 70.10.10.20.4-0.5-0.40.40.5-0.2-0.30.3-0.30.3-0.3-0.2
Stereotopy head waving bouts, day 70.91.11.4-1.01.11.2-1.2-1.10.51.0-1.01.0-1.01.00.9
Stereotopy head waving duration, day 70.20.30.4-0.50.60.6-0.6-0.60.20.5-0.50.5-0.50.50.4
Locomotion velocity, session 87.38.89.43.1-3.0-2.92.93.0-3.0-3.03.0-3.02.9-2.9-2.8
Locomotion distance, session 81.72.42.71.5-1.5-1.61.61.6-1.2-1.61.6-1.61.6-1.6-1.6
Degree of sensitization distance0.30.30.50.7-0.7-0.50.50.6-0.6-0.50.5-0.50.4-0.4-0.3
Degree of sensitization stereotypy1.61.82.1-1.31.41.5-1.5-1.50.71.4-1.31.4-1.41.41.2
Conditioned locomotion0.10.10.4-0.40.30.3-0.3-0.20.70.4-0.40.4-0.40.40.4
Cocaine response after cond. corrected2.32.63.3-1.51.71.8-1.8-1.81.41.6-1.61.6-1.61.61.3
Cocaine response after cond. not corrected3.74.15.1-1.92.12.2-2.2-2.31.42.0-2.02.0-2.02.11.8
Cocaine response before conditioning0.91.11.9-0.90.91.1-1.1-1.10.11.1-1.11.1-1.11.11.4
Saline control response0.30.30.6-0.40.40.6-0.6-0.6-0.10.6-0.60.6-0.70.70.8
Bone: connectivity density3.04.75.3-2.32.32.2-2.2-2.12.32.2-2.22.1-2.12.11.9
Bone: cortical apparent density6.07.99.0-2.92.92.9-2.9-2.83.02.8-2.82.8-2.72.72.4
Bone: cortical area0.20.30.4-0.50.60.6-0.6-0.60.10.5-0.50.5-0.50.50.3
Bone: cortical porosity0.70.70.8-0.80.80.9-0.9-0.90.60.9-0.90.9-0.90.90.9
Bone: cortical porosity0.90.91.3-0.80.91.0-1.0-1.00.41.0-1.01.0-1.01.01.1
Bone: cortical thickness1.62.63.5-1.61.81.8-1.8-1.91.11.6-1.61.6-1.61.61.2
Bone: cortical thickness5.46.36.7-2.52.52.6-2.6-2.62.32.5-2.52.5-2.52.52.4
Bone: cortical tissue density6.07.99.1-2.92.92.9-2.9-2.83.02.8-2.82.8-2.82.72.4
Condit. Reinf. active minus inactive responses0.50.61.0-0.80.70.7-0.7-0.71.00.7-0.70.7-0.70.70.7
Condit. Reinf. active-inactive response ratio0.70.81.1-0.90.80.8-0.8-0.80.90.9-0.90.9-0.90.91.1
Condit. Reinf. active responses0.70.91.1-1.01.01.0-1.0-1.00.90.9-0.90.9-0.90.90.8
Condit. Reinf. inactive responses0.50.60.9-0.70.81.0-1.0-0.90.20.8-0.70.8-0.80.80.7
Incentive salience index mean1.51.82.7-1.51.41.3-1.3-1.31.61.3-1.31.3-1.31.31.3
Condit. Reinf. lever presses1.11.52.1-1.31.31.2-1.2-1.21.51.2-1.21.2-1.21.21.1
Condit. Reinf. active minus inactive responses0.50.70.8-0.90.80.8-0.8-0.80.90.8-0.80.8-0.80.80.9
Condit. Reinf. active-inactive response ratio0.30.30.8-0.60.60.5-0.5-0.50.90.5-0.50.5-0.40.40.4
Condit. Reinf. active responses1.11.51.9-1.31.21.1-1.1-1.11.41.2-1.21.2-1.21.21.4
Condit. Reinf. inactive responses2.42.94.0-1.71.61.6-1.6-1.61.71.7-1.71.7-1.81.82.0
Condit. Reinf. lever presses0.00.00.1-0.20.20.2-0.2-0.20.20.2-0.20.2-0.20.20.3
Condit. Reinf. lever reinforcers received1.01.42.2-1.31.11.1-1.1-1.11.51.2-1.21.2-1.21.21.3
Conditioned reinforcement - actives1.31.32.4-1.01.01.2-1.2-0.90.51.2-1.21.2-1.31.31.5
Conditioned reinforcement - inactives1.31.52.3-1.31.11.0-1.0-0.91.51.2-1.21.2-1.21.21.5
Conditioned locomotion1.11.32.1-1.11.11.1-1.1-1.10.61.2-1.21.3-1.31.31.5
Patch foraging indifference point 0 sec1.52.44.2-1.61.61.3-1.3-1.42.01.5-1.61.5-1.51.51.5
Patch foraging indifference point AUC0.00.10.40.10.00.1-0.10.0-0.1-0.20.2-0.20.2-0.2-0.6
Delay disc. indifference point, 0s delay1.31.51.9-1.21.21.2-1.2-1.31.41.2-1.21.2-1.21.21.0
Delay disc. indifference point, 16s delay0.70.70.8-0.90.90.8-0.8-0.80.80.9-0.90.9-0.90.90.8
Delay disc. indifference point, 2s delay2.32.62.8-1.61.61.6-1.6-1.61.31.7-1.71.7-1.71.71.6
Delay disc. indifference point, 24s delay0.10.10.1-0.20.30.3-0.3-0.20.10.3-0.30.3-0.30.30.1
Delay disc. indifference point, 4s delay0.60.60.9-0.90.90.6-0.6-0.90.80.8-0.80.8-0.80.80.7
Delay disc. indifference point, 8s delay0.60.61.2-0.70.60.5-0.5-0.60.50.9-0.90.9-0.90.91.1
Indifference point function ln k0.00.00.1-0.00.0-0.10.1-0.10.00.1-0.10.1-0.10.10.3
Indifference point function log k0.00.00.1-0.00.0-0.10.1-0.10.00.1-0.10.1-0.10.10.3
Patch foraging total patch changes 0 sec1.01.63.3-1.41.31.0-1.0-1.21.81.2-1.31.2-1.21.21.2
Patch foraging total patch changes 12 sec4.96.37.9-2.72.62.5-2.5-2.42.82.5-2.52.5-2.52.52.2
Patch foraging total patch changes 18 sec0.50.60.9-0.80.90.9-0.9-0.80.90.7-0.70.7-0.70.70.4
Patch foraging total patch changes 24 sec2.22.73.5-1.71.81.9-1.9-1.81.61.6-1.61.6-1.51.51.1
Patch foraging total patch changes 6 sec1.72.45.0-1.71.71.5-1.5-1.62.21.5-1.51.5-1.41.41.1
Patch foraging time to switch 0 sec0.00.10.1-0.30.20.2-0.2-0.20.30.3-0.30.3-0.30.30.3
Patch foraging water rate 0 sec0.00.00.10.0-0.1-0.30.30.20.3-0.10.1-0.10.1-0.2-0.2
Patch foraging water rate 12 sec0.30.40.50.7-0.6-0.70.70.6-0.6-0.70.7-0.70.7-0.7-0.7
Patch foraging water rate 18 sec0.50.61.0-0.80.70.7-0.7-0.70.60.8-0.90.9-0.90.91.0
Patch foraging water rate 24 sec0.30.40.7-0.70.60.4-0.4-0.40.80.7-0.70.7-0.70.70.8
Patch foraging water rate 6 sec0.91.42.6-1.31.21.1-1.1-1.01.61.1-1.11.1-1.11.11.1
Seeking ratio, delayed vs. immediate footshock0.10.10.5-0.20.10.4-0.4-0.10.70.0-0.00.0-0.0-0.0-0.1
Distance traveled before self-admin0.20.20.40.4-0.6-0.60.60.5-0.1-0.40.4-0.40.4-0.4-0.1
Distance traveled after self-admin1.71.92.61.4-1.6-1.41.41.6-1.2-1.41.4-1.41.4-1.3-1.1
Extensor digitorum longus weight8.734.238.26.1-5.9-5.75.75.6-6.2-5.95.9-5.95.8-5.8-5.7
Bone: elastic displacement0.00.00.0-0.10.10.1-0.1-0.2-0.00.1-0.10.1-0.10.10.1
Bone: elastic work0.00.00.0-0.10.10.1-0.10.00.2-0.00.0-0.00.0-0.0-0.1
Bone: endosteal estimation2.24.75.62.2-2.3-2.22.22.4-2.0-2.12.1-2.12.1-2.1-1.9
Bone: endosteal perimeter1.93.94.61.9-2.1-2.12.12.1-1.7-2.02.0-2.02.0-2.0-1.8
Epididymis fat weight0.30.61.20.8-1.0-0.80.81.1-0.5-0.80.8-0.80.8-0.8-0.5
Delta time in closed arm before/after self-admin3.83.74.01.9-2.0-2.02.01.9-2.0-1.91.9-1.91.9-1.9-1.8
Delta time in open arm before/after self-admin0.00.00.1-0.20.20.1-0.1-0.20.00.2-0.20.2-0.20.20.1
Diff in mean of infusions in LGA sessions0.30.40.80.6-0.9-0.70.70.9-0.6-0.40.5-0.40.4-0.40.0
Delay discount exponential model param0.40.40.50.6-0.6-0.50.50.6-0.4-0.70.7-0.70.7-0.7-0.7
Extinction: sum of active levers before priming0.90.92.01.0-1.1-1.11.11.0-1.4-0.80.8-0.80.8-0.8-0.6
Active lever presses in extinction session 60.50.52.3-0.80.60.5-0.5-0.51.50.6-0.60.6-0.50.50.6
Bone: final force1.22.02.4-1.31.41.5-1.5-1.31.01.4-1.41.4-1.51.51.3
Bone: final moment1.01.62.0-1.21.21.4-1.4-1.20.81.3-1.31.3-1.31.31.2
Food consumed during 24 hour testing period1.01.21.81.1-1.0-1.01.01.0-1.0-1.11.1-1.11.1-1.1-1.3
Glucose0.60.91.0-0.91.00.9-0.9-1.00.91.0-1.01.0-1.01.00.9
Heart weight3.24.65.72.1-2.3-2.42.42.3-1.8-2.12.1-2.12.1-2.1-1.9
Delay discount hyperbolic model param0.60.60.80.8-0.8-0.70.70.7-0.6-0.90.9-0.90.9-0.9-0.9
Intermittent access intake day 1-15 change0.20.20.4-0.40.30.3-0.3-0.30.50.4-0.40.4-0.40.40.6
Intermittent access intake escalation0.10.10.3-0.30.20.1-0.1-0.20.50.2-0.20.2-0.20.20.4
Intermittent access intake escalation 20.10.10.10.2-0.3-0.20.20.1-0.0-0.30.3-0.30.3-0.3-0.4
Intermitt. access day 1 inactive lever presses1.01.03.2-1.10.80.7-0.7-0.61.81.0-0.90.9-0.90.91.1
Intermitt. access day 15 inactive lever presses3.23.55.6-2.12.01.8-1.8-1.92.41.8-1.81.8-1.71.71.7
Intermitt. access escalation Index1.21.13.91.1-0.9-0.90.90.8-2.0-0.90.9-0.90.8-0.8-1.0
Intermittent access day 1 total infusions0.10.10.3-0.30.30.2-0.2-0.20.40.4-0.40.4-0.40.40.5
Intermittent access day 15 total infusions0.30.30.6-0.50.40.3-0.3-0.30.70.5-0.50.5-0.50.50.8
Intermittent access terminal intake (last 3 days)0.40.40.7-0.60.50.5-0.5-0.50.80.6-0.60.6-0.60.60.8
Intermittent access total infusions0.00.00.2-0.10.00.0-0.00.10.30.2-0.20.2-0.20.20.4
Intermittent access day 1 locomotion0.30.40.6-0.60.50.4-0.4-0.40.80.6-0.60.6-0.60.60.8
Intermittent access day 15 total locomotion0.60.61.0-0.80.70.6-0.6-0.70.70.8-0.80.8-0.80.81.0
Intermittent access total locomotion0.70.81.2-0.90.80.7-0.7-0.71.00.9-0.90.9-0.90.91.1
Intermittent access standard deviation0.30.41.7-0.70.50.4-0.4-0.51.30.5-0.50.5-0.40.40.5
Left kidney weight2.36.57.82.4-2.5-2.52.52.6-2.0-2.62.6-2.62.7-2.7-2.8
Right kidney weight0.51.32.01.1-1.1-1.01.01.1-1.0-1.21.2-1.21.2-1.2-1.4
Cocaine induced anxiety2.22.53.01.6-1.6-1.51.51.5-1.7-1.61.6-1.61.6-1.6-1.6
Post-drug Anxiety0.00.00.30.2-0.2-0.10.10.1-0.5-0.20.2-0.10.1-0.1-0.2
Baseline Anxiety2.93.13.5-1.81.81.7-1.7-1.81.41.8-1.91.9-1.91.91.8
Tail length0.92.93.61.5-1.6-1.81.81.7-0.8-1.81.7-1.81.8-1.8-1.9
Length with tail4.817.518.94.1-4.2-4.34.34.3-3.2-4.24.2-4.24.3-4.3-4.3
Length without tail4.810.611.83.4-3.4-3.43.43.4-2.8-3.23.3-3.23.2-3.2-3.0
Times rat made contact with spout1.01.11.5-1.11.21.2-1.2-1.20.91.0-1.01.0-1.01.00.8
Lifetime Intake0.00.00.1-0.1-0.0-0.00.00.10.30.1-0.10.1-0.10.10.4
Liver weight, left0.10.10.20.2-0.3-0.40.40.4-0.0-0.30.3-0.30.3-0.3-0.3
Liver weight, right0.10.10.7-0.40.30.2-0.2-0.10.80.2-0.20.2-0.20.20.2
Locomotor activity0.61.01.1-0.91.01.1-1.1-1.00.61.0-1.01.0-1.01.00.9
Locomotor testing distance3.05.06.2-2.22.12.2-2.2-2.21.62.3-2.32.3-2.42.42.5
Locomotor testing rearing5.99.19.8-3.13.02.9-2.9-3.03.13.0-3.13.0-3.03.03.0
Locomotion in novel chamber5.56.89.4-2.83.02.6-2.6-3.03.12.4-2.52.4-2.32.31.8
Locomotion in novel chamber post-restriction0.80.91.3-1.01.01.0-1.0-0.91.10.9-0.90.9-0.90.90.6
Fecal boli incidents, locomotor time 10.20.20.50.4-0.3-0.50.50.4-0.2-0.50.5-0.50.5-0.5-0.7
Change in fecal boli incidents, locomotor task0.20.20.3-0.20.20.5-0.5-0.20.10.4-0.40.4-0.50.50.6
Time >=10cm from walls, locomotor time 10.80.81.1-0.80.91.0-1.0-0.90.60.9-0.90.9-0.90.90.9
Bouts of movement, locomotor time 10.50.61.10.9-0.9-0.70.70.8-1.1-0.70.7-0.70.6-0.6-0.4
Total resting periods, locomotor time 10.80.91.91.1-1.1-0.90.91.0-1.4-0.90.9-0.90.8-0.8-0.5
Rest time, locomotor task time 10.00.00.00.0-0.00.0-0.0-0.0-0.00.00.00.00.0-0.0-0.0
Distance moved, locomotor task time 10.20.30.4-0.50.50.5-0.5-0.40.50.5-0.50.5-0.50.50.6
Vertical activity count, locomotor time 10.00.00.10.1-0.2-0.30.30.2-0.1-0.10.1-0.10.1-0.10.2
Time >=10cm from walls, locomotor time 22.12.22.6-1.51.51.4-1.4-1.61.31.5-1.51.5-1.51.51.4
Bouts of movement, locomotor time 20.10.10.3-0.30.10.1-0.1-0.30.30.3-0.30.3-0.30.30.6
Total resting periods, locomotor time 20.00.00.1-0.0-0.1-0.20.2-0.00.10.1-0.10.1-0.10.10.4
Rest time, locomotor task time 21.21.42.11.1-1.2-1.41.41.2-0.9-1.11.1-1.11.1-1.1-1.0
Distance moved, locomotor task time 20.00.00.1-0.20.2-0.00.0-0.20.30.1-0.10.1-0.10.1-0.1
Vertical activity count, locomotor time 20.00.00.00.2-0.2-0.20.20.2-0.2-0.10.1-0.10.1-0.10.0
Light reinforcement 12.13.74.7-2.11.91.8-1.8-1.72.22.0-2.01.9-1.91.92.0
Light reinforcement 20.70.91.1-1.11.01.0-1.0-0.81.01.0-1.01.0-1.01.00.9
Bone: marrow area2.04.45.32.1-2.2-2.22.22.3-1.9-2.12.1-2.12.1-2.1-1.9
Bone: maximum diameter0.00.00.0-0.10.20.2-0.2-0.10.10.1-0.10.1-0.10.1-0.0
Bone: maximum force0.00.10.1-0.20.20.4-0.4-0.2-0.00.3-0.30.3-0.30.30.2
Bone: maximum moment0.00.00.1-0.10.10.2-0.2-0.1-0.20.2-0.10.2-0.20.20.1
Mean time between licks in bursts1.42.02.41.5-1.5-1.41.41.4-1.6-1.41.4-1.41.4-1.4-1.3
Mean num. licks in bursts0.00.00.1-0.20.1-0.00.0-0.00.30.1-0.10.1-0.00.00.1
Cd content in liver0.10.10.3-0.40.30.3-0.3-0.20.30.4-0.40.4-0.40.40.5
Co content in liver1.31.51.81.2-1.2-1.11.11.3-1.0-1.31.3-1.31.3-1.3-1.3
Cu content in liver0.80.91.30.7-0.9-1.01.01.20.1-1.01.0-1.01.0-1.1-1.1
Fe content in liver1.51.82.21.3-1.3-1.51.51.3-1.1-1.31.3-1.31.4-1.4-1.4
K content in liver0.50.52.0-0.80.80.5-0.5-0.71.40.6-0.60.6-0.50.50.3
Mg content in liver0.40.41.0-0.70.80.5-0.5-0.71.00.6-0.60.6-0.50.50.3
Mn content in liver0.80.92.5-1.11.00.8-0.8-0.81.60.8-0.90.8-0.80.80.6
Na content in liver0.20.20.3-0.50.60.5-0.5-0.50.60.5-0.50.5-0.50.50.3
Rb content in liver1.31.62.9-1.31.21.0-1.0-1.11.71.2-1.31.2-1.21.21.2
Se content in liver2.83.46.2-2.12.01.8-1.8-1.82.51.8-1.81.7-1.71.71.5
Sr content in liver0.10.10.20.2-0.3-0.40.40.40.1-0.40.3-0.40.4-0.4-0.4
Zn content in liver1.82.02.6-1.61.41.2-1.2-1.31.61.4-1.51.4-1.41.41.4
Bone: minimum diameter0.50.91.00.9-1.0-1.01.01.0-1.0-0.90.9-0.90.9-0.9-0.9
Time in familiar zone, hab. session 10.60.50.7-0.80.70.6-0.6-0.70.70.8-0.80.8-0.80.80.9
Time in novel zone, hab. session 10.70.70.8-0.80.80.9-0.9-0.80.70.8-0.80.8-0.80.80.8
Total zone transitions, hab. session 12.33.33.81.8-1.7-1.81.81.8-1.6-1.91.9-1.91.9-1.9-1.9
Total locomotion distance, hab. session 10.00.00.10.2-0.2-0.20.20.3-0.3-0.20.2-0.20.2-0.2-0.2
Locomotion velocity, hab. session 10.70.91.20.9-1.0-0.90.91.1-1.0-0.91.0-1.00.9-0.9-0.9
Time in familiar zone, hab. session 20.50.50.7-0.80.70.5-0.5-0.60.80.7-0.70.7-0.70.70.8
Time in novel zone, hab. session 20.10.10.1-0.20.20.3-0.3-0.20.30.2-0.20.2-0.20.20.2
Total zone transitions, hab. session 20.60.80.90.9-0.9-1.01.00.9-0.6-0.90.9-0.90.9-0.9-0.9
Total locomotion distance, hab. session 20.10.10.30.4-0.4-0.40.40.4-0.5-0.30.3-0.30.3-0.3-0.2
Locomotion velocity, hab. session 20.30.40.50.6-0.7-0.70.70.7-0.7-0.60.6-0.60.6-0.6-0.4
Novel to familiar place preference ratio1.51.52.01.3-1.2-1.21.21.1-1.4-1.21.2-1.21.2-1.2-1.3
Novelty place preference0.91.01.81.0-1.0-0.90.90.9-1.3-0.90.9-0.90.9-0.9-0.9
Time in novel zone, NPP test0.20.30.90.5-0.5-0.40.40.4-0.9-0.50.5-0.40.4-0.4-0.5
Total zone transitions, NPP test0.30.50.50.7-0.7-0.70.70.7-0.3-0.70.7-0.70.7-0.7-0.7
Total locomotion distance, NPP test0.00.00.1-0.10.10.1-0.1-0.00.20.0-0.10.0-0.00.00.0
Locomotion velocity, NPP test0.30.40.50.6-0.6-0.60.60.7-0.4-0.60.6-0.60.6-0.6-0.6
Intraocular pressure1.52.14.31.6-1.6-1.51.51.3-2.1-1.31.4-1.31.3-1.3-1.1
Delta distance traveled before/after self-admin1.21.21.71.2-1.2-1.01.01.1-1.3-1.11.1-1.11.1-1.1-1.0
Delta ambulatory time before/after self-admin0.40.41.20.8-0.7-0.60.60.7-1.1-0.50.6-0.60.5-0.5-0.5
Parametrial fat weight0.61.22.0-1.20.90.7-0.7-0.81.41.1-1.11.1-1.11.11.4
Pavlov. Cond. lever latency3.13.94.22.1-2.0-2.02.01.9-2.0-2.02.0-2.02.0-2.0-1.9
Pavlov. Cond. magazine entry latency10.813.914.6-3.83.83.8-3.8-3.83.53.8-3.73.7-3.73.73.7
Pavlov. Cond. change in total contacts8.69.210.0-3.23.13.1-3.1-3.13.03.0-3.03.0-3.03.02.8
Pavlov. Cond. index score9.211.612.3-3.53.53.4-3.4-3.43.33.4-3.43.4-3.43.43.3
Pavlov. Cond. latency score7.19.19.6-3.13.13.0-3.0-3.02.93.0-3.03.0-3.03.02.9
Pavlov. Cond. lever contacts2.73.23.4-1.91.81.8-1.8-1.81.71.8-1.81.8-1.81.81.7
Pavlov. Cond. magazine entry number13.617.017.94.2-4.2-4.24.24.2-3.9-4.14.1-4.14.1-4.1-3.9
Pavlov. Cond. intertrial magazine entries1.51.92.01.4-1.4-1.31.31.3-1.3-1.41.4-1.41.4-1.4-1.4
Pavlov. Cond. lever-magazine prob. diff.10.412.913.6-3.73.63.6-3.6-3.63.43.6-3.63.6-3.63.63.5
Pavlov. Cond. response bias10.212.413.1-3.63.63.5-3.5-3.53.33.5-3.53.5-3.53.53.4
Pavlov. Cond. lever latency0.20.30.30.5-0.6-0.60.60.5-0.4-0.50.5-0.50.5-0.5-0.5
Pavlov. Cond. magazine entry latency0.00.00.30.2-0.1-0.00.0-0.0-0.5-0.20.2-0.20.2-0.2-0.2
Pavlov. Cond. change in total contacts0.50.60.9-0.90.80.8-0.8-0.71.00.8-0.80.8-0.80.80.8
Pavlov. Cond. index score0.20.20.3-0.50.50.5-0.5-0.60.30.4-0.40.4-0.40.40.4
Pavlov. Cond. latency score0.10.10.2-0.30.40.4-0.4-0.40.10.3-0.30.3-0.30.30.3
Pavlov. Cond. lever contacts0.81.01.2-1.01.01.1-1.1-1.00.81.0-1.01.0-1.01.01.0
Pavlov. Cond. magazine entry number0.10.10.20.3-0.4-0.40.40.4-0.0-0.30.3-0.30.3-0.3-0.3
Pavlov. Cond. intertrial magazine entries1.62.12.51.5-1.5-1.41.41.4-1.6-1.41.5-1.41.4-1.4-1.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.30.40.3-0.3-0.40.10.3-0.30.3-0.30.30.2
Pavlov. Cond. response bias0.91.31.4-1.21.21.2-1.2-1.21.01.1-1.11.1-1.11.11.1
Time in closed arm before self-admin1.21.41.6-1.21.11.3-1.3-1.11.21.2-1.21.2-1.21.21.2
Time in closed arm after self-admin0.70.70.80.8-0.8-0.90.90.7-0.8-0.80.8-0.80.8-0.8-0.9
Time in open arm before self-admin3.13.33.91.8-1.9-2.02.01.8-1.4-1.91.8-1.91.9-1.9-1.7
Time in open arm after self-admin0.60.60.80.8-0.8-0.90.90.9-0.6-0.80.8-0.80.8-0.8-0.7
Bone: periosteal estimation0.20.40.50.6-0.7-0.60.60.7-0.7-0.60.6-0.60.6-0.6-0.6
Bone: periosteal perimeter0.71.11.41.1-1.1-1.11.11.1-1.2-1.11.0-1.01.0-1.0-1.0
Bone: post-yield work1.01.42.11.3-1.3-1.11.11.2-1.5-1.11.1-1.11.1-1.1-1.1
Progressive ratio test 1 active lever presses1.21.31.5-1.11.11.2-1.2-1.10.71.2-1.11.2-1.21.21.2
Progressive ratio test 1 breakpoint1.21.21.6-1.01.01.2-1.2-1.00.61.1-1.11.1-1.21.21.3
Progressive ratio test 1 inactive lever presses1.01.01.6-1.10.90.8-0.8-0.81.31.0-1.01.0-1.01.01.2
Progressive ratio test 2 active lever presses1.21.31.4-1.11.11.1-1.1-1.11.01.1-1.11.1-1.11.11.2
Progressive ratio test 2 breakpoint1.01.21.4-1.01.01.2-1.2-1.10.81.1-1.11.1-1.11.11.2
Progressive ratio test 2 inactive lever presses0.10.10.7-0.40.30.1-0.1-0.20.80.2-0.20.2-0.20.10.2
Incentive Sensitization - Responses1.21.21.5-1.11.11.2-1.2-1.21.21.0-1.11.1-1.01.01.0
Incentive Sensitization - Breakpoint1.21.21.5-1.11.21.1-1.1-1.21.21.0-1.11.0-1.01.00.9
Sum of active levers in priming session hrs 5-60.50.50.7-0.70.60.6-0.6-0.50.80.7-0.70.7-0.70.70.8
Progressive ratio0.10.10.7-0.20.10.2-0.20.00.80.1-0.10.0-0.00.0-0.0
Food seeking constrained by brief footshock0.20.30.5-0.50.50.7-0.7-0.40.40.5-0.50.5-0.50.50.5
Seeking ratio, punishment vs. effort0.20.20.3-0.20.40.4-0.4-0.6-0.60.4-0.40.4-0.50.50.5
Retroperitoneal fat weight0.10.20.60.5-0.7-0.50.50.8-0.1-0.50.5-0.50.5-0.5-0.2
Reaction time number correct0.81.21.61.1-1.0-1.31.31.0-1.0-1.11.1-1.11.1-1.1-1.1
Reaction time mean minus median0.10.10.80.4-0.3-0.20.20.2-0.9-0.30.3-0.30.2-0.2-0.1
Reaction time mean minus median AUC0.20.30.5-0.40.40.7-0.7-0.6-0.30.6-0.50.6-0.60.60.7
Reaction time num false alarms0.81.11.4-1.01.01.0-1.0-1.11.01.1-1.11.1-1.11.11.2
Reaction time num false alarms AUC0.60.81.0-0.90.90.9-0.9-0.90.70.9-0.90.9-0.90.91.0
Reaction time trials correct on left0.81.21.61.1-1.0-1.31.31.0-1.0-1.11.1-1.11.1-1.1-1.1
Reaction time trials on left0.81.21.61.1-1.0-1.21.21.0-1.0-1.11.0-1.01.0-1.0-1.0
Reaction time mean0.00.00.1-0.10.20.2-0.2-0.3-0.10.1-0.10.1-0.10.10.0
Reaction time mean AUC0.00.00.0-0.10.10.1-0.1-0.2-0.1-0.0-0.00.00.0-0.0-0.0
Median of all reaction times0.30.40.6-0.70.80.7-0.7-0.80.50.5-0.60.5-0.50.50.4
Reaction time omissions0.71.01.3-1.11.11.0-1.0-1.01.11.0-1.01.0-1.01.01.0
Reaction time false alarm rate1.31.82.1-1.31.31.4-1.4-1.31.21.4-1.31.3-1.41.41.5
Reaction time premature initiation rate0.30.40.6-0.50.50.8-0.8-0.50.30.7-0.60.7-0.70.70.5
Reaction time premature initiations0.00.10.20.3-0.3-0.20.20.3-0.5-0.20.2-0.20.1-0.1-0.3
Std. dev. reaction times0.00.00.2-0.00.10.2-0.2-0.2-0.40.1-0.00.1-0.10.10.1
Reaction time trials completed0.81.21.61.1-1.0-1.21.21.0-1.0-1.11.0-1.01.0-1.0-1.0
Reaction time trials AUC0.60.91.31.0-0.9-1.11.10.8-1.0-0.90.9-0.90.9-0.9-0.9
Run reversals in cocaine runway, females2.62.53.61.7-1.7-1.61.61.6-1.9-1.61.5-1.51.5-1.5-1.3
Run reversals in cocaine runway, males0.70.60.9-0.90.80.8-0.8-0.90.90.7-0.80.8-0.70.70.7
Latency to leave start box in cocaine runway2.83.03.81.7-1.7-1.71.71.8-1.0-1.91.8-1.91.9-1.9-2.0
Latency to leave start box in cocaine runway, F2.62.83.61.6-1.6-1.71.71.7-1.2-1.71.7-1.71.8-1.8-1.9
Latency to leave start box in cocaine runway, M0.20.20.60.1-0.2-0.40.40.40.8-0.50.4-0.50.5-0.5-0.6
Std. dev. time between licks in bursts0.20.30.40.5-0.5-0.40.40.5-0.5-0.60.6-0.60.6-0.6-0.6
Total sessions with >9 infusions0.80.91.1-0.90.90.9-0.9-0.70.91.0-0.91.0-1.01.01.1
Short access day 1 total inactive lever presses1.61.83.0-1.41.21.1-1.1-1.01.71.4-1.31.4-1.31.31.6
Short access day 10 total inactive lever presses0.50.61.00.7-0.8-0.70.71.0-0.2-0.80.8-0.80.8-0.8-0.7
Short access day 1 total infusions0.20.21.0-0.50.30.3-0.3-0.21.00.4-0.40.4-0.40.40.5
Short access day 10 total infusions0.20.20.3-0.50.40.3-0.3-0.30.50.5-0.50.5-0.50.50.6
Short access total infusions0.00.00.2-0.1-0.00.0-0.00.20.40.1-0.00.1-0.10.10.2
Short access day 1 locomotion2.62.84.6-1.81.71.6-1.6-1.62.11.6-1.61.6-1.61.61.5
Short access day 10 total locomotion1.92.12.4-1.51.41.3-1.3-1.21.51.5-1.51.5-1.51.51.6
Short access total locomotion0.50.50.9-0.70.50.5-0.5-0.30.90.7-0.70.7-0.70.70.9
One hour access (0.3 mA shock)0.00.00.3-0.0-0.10.1-0.10.0-0.20.2-0.20.2-0.20.20.5
Compulsive drug intake0.10.10.40.4-0.4-0.00.00.3-0.6-0.20.3-0.20.2-0.2-0.1
One hour access (shock baseline)0.20.20.5-0.40.30.1-0.1-0.30.50.5-0.50.5-0.50.50.7
Social response proportion0.00.00.10.1-0.10.0-0.0-0.1-0.10.1-0.00.1-0.10.10.3
Social responses0.10.10.5-0.40.30.2-0.2-0.30.70.3-0.30.3-0.30.30.4
Social time0.00.00.00.1-0.1-0.10.10.1-0.1-0.10.1-0.10.1-0.1-0.0
Soleus weight0.41.31.7-0.91.11.3-1.3-1.30.31.1-1.11.1-1.21.21.1
Bone: stiffness0.00.10.1-0.20.20.3-0.3-0.2-0.10.3-0.30.3-0.30.30.2
Tibialis anterior weight1.44.75.22.2-2.1-2.22.21.9-2.3-2.22.2-2.22.2-2.2-2.2
Time to tail flick, vehicle, before self-admin0.20.20.3-0.40.40.4-0.4-0.40.10.4-0.40.4-0.50.50.6
Time to tail flick, vehicle, after self-admin0.10.10.3-0.30.40.5-0.5-0.50.40.3-0.30.3-0.30.30.2
Time to tail flick, test, before self-admin0.90.91.91.1-1.1-0.90.90.9-1.4-0.80.9-0.80.8-0.8-0.6
Time to tail flick, test, after self-admin0.10.10.7-0.40.50.3-0.3-0.40.90.2-0.30.2-0.20.2-0.1
Delta time to tail flick, vehicle, before/after SA0.40.40.6-0.60.60.8-0.8-0.60.60.6-0.50.6-0.60.60.4
Delta time to tail flick, test, before/after SA2.42.24.4-1.71.71.4-1.4-1.62.11.3-1.41.3-1.31.31.0
Tibia length0.92.54.81.7-1.5-1.31.31.4-2.2-1.51.6-1.51.5-1.5-1.6
Ambulatory time before self-admin0.40.40.70.6-0.7-0.80.80.7-0.4-0.70.6-0.60.7-0.7-0.4
Ambulatory time after self-admin3.13.44.21.9-2.0-1.81.82.0-1.7-1.81.9-1.91.8-1.8-1.7
Bone: tissue strength0.40.41.00.7-0.6-0.50.50.5-1.0-0.60.7-0.60.6-0.6-0.8
Total heroin consumption0.40.51.5-0.80.80.6-0.6-0.71.20.6-0.70.6-0.60.60.5
Bone: trabecular number5.38.39.0-3.03.02.9-2.9-2.93.02.9-2.92.9-2.82.82.6
Bone: trabecular spacing1.01.21.71.2-1.2-1.21.21.1-1.3-1.11.1-1.01.0-1.0-0.9
Bone: trabecular thickness0.00.00.1-0.20.30.3-0.3-0.20.10.1-0.10.1-0.10.1-0.1
Bone: trabecular tissue density0.00.00.0-0.00.10.1-0.1-0.10.10.1-0.10.1-0.10.10.1
Water consumed over 24 hours0.00.00.10.1-0.00.1-0.10.0-0.4-0.00.1-0.00.0-0.0-0.1
Number of responses in last shaping day0.10.10.8-0.20.1-0.10.1-0.10.9-0.10.1-0.10.2-0.2-0.3