Hub : Genes

Arih2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	intron excision ratio	chr8_109314456_109327204	0.18	0.1	2.6e-03	0.06	0.06	0.05	0.04	1.3e-02	1.5e-02	2.2e-02	4.7e-02
2	Adipose	isoform ratio	XM_039081598.1	0.03	0.02	1.7e-03	0.01	0.01	0.01	0.01	1.5e-02	7.4e-03	3.2e-02	1.9e-02
3	RMTg	alternative TSS	XM_039081599.1	0.2	0.12	1.4e-03	0.03	-0.01	0	0.02	5.2e-02	7.0e-01	3.0e-01	9.1e-02
4	RMTg	alternative TSS	XM_039081599.1	0.17	0.11	8.3e-03	0.01	-0.01	-0.01	-0.01	1.7e-01	9.6e-01	6.3e-01	5.6e-01
5	Liver	alternative TSS	XM_008766537.3	0.03	0.02	4.2e-03	0.01	0	-0	0	1.9e-02	2.3e-01	3.8e-01	2.4e-01
6	Liver	gene expression	Arih2	0.03	0.02	6.6e-03	0	-0	-0	-0	2.1e-01	9.1e-01	6.5e-01	8.3e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.9	1.5	2.1	0.2	1.1	1.5	1.3	-1.3	1.4
Area under the delay curve	0.5	0.6	1.5	-1.2	0.0	0.3	0.8	-0.8	0.8
BMI with tail	0.3	0.9	2.3	1.5	-0.2	-0.9	0.7	-0.7	-1.0
BMI without tail	0.7	1.4	5.0	2.2	0.9	-0.4	1.2	-1.2	-0.1
Body weight	1.3	5.5	29.0	5.4	1.5	-0.5	0.6	-0.6	-1.0
Weight adjusted by age	0.7	0.8	1.2	0.7	-0.4	-0.4	-1.1	1.1	-1.1
Bone surface	0.1	0.1	0.2	-0.2	-0.1	0.3	0.5	-0.5	0.0
Bone volume	0.2	0.3	0.6	0.0	0.3	0.7	0.8	-0.7	0.4
Breakpoint value in progressive ratio session	0.3	0.3	0.5	0.3	0.7	0.3	0.7	-0.7	0.7
Number of licking bursts	2.3	2.8	4.3	-0.6	-1.6	-2.1	-1.8	1.8	-1.6
Context. condit. distance diff. score	0.1	0.1	0.1	-0.0	-0.2	-0.4	-0.3	0.2	-0.3
Locomotion velocity, session 1	0.2	0.2	0.3	-0.2	0.2	0.6	0.5	-0.6	0.4
Locomotion distance, session 1	1.3	1.7	2.7	1.2	1.2	0.8	1.6	-1.7	0.9
Locomotion velocity, session 2	0.1	0.2	0.4	-0.4	-0.6	-0.0	-0.1	0.1	-0.6
Locomotion distance, session 2	0.7	0.9	2.1	0.0	0.6	0.8	1.4	-1.5	0.7
Locomotion velocity, session 3	1.4	1.7	3.3	0.5	1.1	1.2	1.7	-1.8	1.0
Locomotion distance, session 3	0.6	0.7	1.4	-1.0	0.0	0.5	1.1	-1.2	0.5
Stereotopy head waving bouts, day 3	1.7	2.1	3.2	0.1	-1.3	-1.2	-1.8	1.8	-1.7
Stereotopy head waving duration, day 3	0.4	0.5	1.2	0.4	-0.4	-0.4	-1.0	1.1	-0.6
Locomotion velocity, session 7	1.7	1.8	3.2	0.2	1.3	1.8	1.3	-1.4	1.5
Locomotion distance, session 7	0.5	0.7	1.3	-1.1	0.1	0.9	0.8	-0.8	0.7
Stereotopy head waving bouts, day 7	0.2	0.2	0.6	-0.1	0.3	0.8	0.4	-0.4	0.5
Stereotopy head waving duration, day 7	0.3	0.4	0.4	0.7	0.7	0.4	0.6	-0.6	0.6
Locomotion velocity, session 8	0.9	1.1	2.4	0.6	0.8	0.6	1.4	-1.6	0.7
Locomotion distance, session 8	2.0	2.9	5.8	0.7	1.5	1.3	2.2	-2.4	1.4
Degree of sensitization distance	0.2	0.2	0.8	0.9	0.6	0.3	-0.1	0.2	0.4
Degree of sensitization stereotypy	1.1	1.2	2.2	0.3	1.0	1.5	1.0	-1.1	1.2
Conditioned locomotion	0.7	0.8	3.9	-2.0	-0.4	0.2	0.2	-0.2	0.6
Cocaine response after cond. corrected	1.8	2.0	2.9	0.4	-1.2	-1.5	-1.6	1.6	-1.7
Cocaine response after cond. not corrected	0.9	0.9	2.0	1.4	-0.3	-0.7	-0.9	0.9	-1.2
Cocaine response before conditioning	1.6	2.0	2.4	1.4	1.5	1.4	1.5	-1.5	1.1
Saline control response	3.2	4.2	6.7	1.3	2.4	2.6	1.7	-1.7	2.3
Bone: connectivity density	1.3	2.0	3.4	-0.5	1.2	1.8	1.4	-1.4	1.9
Bone: cortical apparent density	0.1	0.1	0.3	-0.5	0.2	0.3	0.2	-0.2	0.6
Bone: cortical area	2.3	3.4	5.1	-0.5	-2.0	-1.8	-2.0	2.0	-2.3
Bone: cortical porosity	1.7	1.9	3.5	-0.3	1.4	1.7	1.2	-1.2	1.9
Bone: cortical porosity	1.8	2.0	3.7	-0.6	1.3	1.8	1.2	-1.2	1.9
Bone: cortical thickness	2.5	4.1	6.5	0.3	-1.9	-2.2	-2.2	2.2	-2.5
Bone: cortical thickness	0.1	0.1	0.2	-0.0	-0.4	-0.3	-0.4	0.4	-0.4
Bone: cortical tissue density	0.2	0.2	0.4	-0.5	0.3	0.5	0.3	-0.3	0.7
Condit. Reinf. active minus inactive responses	0.5	0.6	1.1	0.1	-0.6	-0.9	-1.1	1.0	-0.6
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.1	0.3	-0.8	-1.3	-1.5	1.5	-1.0
Condit. Reinf. active responses	0.4	0.5	0.9	-0.2	-0.6	-0.9	-0.9	0.8	-0.6
Condit. Reinf. inactive responses	0.1	0.1	0.6	-0.8	-0.2	-0.1	0.1	-0.4	0.1
Incentive salience index mean	0.4	0.4	0.9	-0.3	-0.7	-0.9	-0.7	0.6	-0.6
Condit. Reinf. lever presses	0.5	0.7	1.8	-1.3	-1.0	-1.0	-0.3	0.3	-0.5
Condit. Reinf. active minus inactive responses	0.5	0.6	2.6	1.6	0.5	-0.7	0.3	-0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.8	1.3	0.0	-1.0	-0.0	0.0	-0.6
Condit. Reinf. active responses	0.4	0.5	2.6	1.6	0.6	-0.3	0.2	-0.2	0.1
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	0.1	0.2	-0.0	0.0	0.3
Condit. Reinf. lever presses	0.5	0.7	3.6	1.9	0.6	-0.0	0.4	-0.4	-0.2
Condit. Reinf. lever reinforcers received	0.4	0.6	2.9	1.7	0.6	-0.3	0.2	-0.2	0.1
Conditioned reinforcement - actives	0.1	0.1	0.5	-0.7	-0.0	0.5	-0.2	-0.2	0.2
Conditioned reinforcement - inactives	3.5	3.9	5.7	-1.1	-2.1	-1.7	-2.4	2.1	-2.1
Conditioned locomotion	0.6	0.7	1.2	-0.6	0.6	0.6	0.8	-1.1	1.1
Patch foraging indifference point 0 sec	1.8	2.9	4.4	1.3	2.1	2.0	1.5	-1.4	1.8
Patch foraging indifference point AUC	1.2	1.4	2.2	0.3	1.1	0.8	1.5	-1.5	1.3
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	-0.2	0.0	-1.0	0.3	-0.4	0.4
Delay disc. indifference point, 16s delay	0.3	0.3	0.8	-0.9	-0.0	-0.1	0.5	-0.6	0.6
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	-0.0	-0.2	0.3	-0.3	0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.7	-0.8	0.0	0.2	0.5	-0.5	0.5
Delay disc. indifference point, 4s delay	0.5	0.5	1.5	-1.2	-0.6	-1.1	0.0	-0.0	0.0
Delay disc. indifference point, 8s delay	0.7	0.7	1.6	-1.3	0.1	1.0	0.7	-0.7	0.7
Indifference point function ln k	0.1	0.2	0.4	-0.5	-0.6	-0.3	0.1	-0.1	-0.6
Indifference point function log k	0.1	0.2	0.4	-0.5	-0.6	-0.3	0.1	-0.1	-0.6
Patch foraging total patch changes 0 sec	1.3	2.1	3.4	1.4	1.8	1.7	1.0	-1.0	1.5
Patch foraging total patch changes 12 sec	0.6	0.8	1.3	1.1	1.1	1.0	0.6	-0.6	0.9
Patch foraging total patch changes 18 sec	2.1	2.6	4.3	1.6	2.1	1.6	1.2	-1.2	1.9
Patch foraging total patch changes 24 sec	0.8	1.0	3.5	1.9	1.1	0.4	0.5	-0.5	0.5
Patch foraging total patch changes 6 sec	1.6	2.4	4.0	0.5	1.8	1.3	1.6	-1.6	2.0
Patch foraging time to switch 0 sec	1.1	1.6	2.2	-0.5	-1.2	-1.4	-1.5	1.5	-1.3
Patch foraging water rate 0 sec	0.1	0.1	0.3	0.4	0.4	0.5	0.0	-0.0	0.2
Patch foraging water rate 12 sec	0.0	0.1	0.2	0.4	0.1	-0.2	0.2	-0.2	-0.1
Patch foraging water rate 18 sec	0.6	0.8	1.8	0.0	-0.9	-1.3	-0.6	0.6	-1.2
Patch foraging water rate 24 sec	0.1	0.2	0.9	1.0	0.3	0.1	-0.1	0.1	-0.2
Patch foraging water rate 6 sec	0.2	0.3	0.5	0.6	0.5	0.3	0.7	-0.7	0.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	2.9	-1.7	-0.1	0.2	0.6	-0.6	0.6
Distance traveled before self-admin	0.9	1.0	1.5	-0.2	-1.0	-0.7	-1.2	1.2	-1.2
Distance traveled after self-admin	0.4	0.5	0.7	-0.5	-0.8	-0.8	-0.7	0.7	-0.7
Extensor digitorum longus weight	0.3	1.2	1.7	-0.8	-1.3	-1.0	-1.2	1.1	-1.2
Bone: elastic displacement	0.7	0.8	1.1	0.2	-0.7	-1.0	-1.0	1.0	-1.0
Bone: elastic work	0.6	0.8	1.4	0.8	-0.7	-1.1	-0.7	0.6	-1.2
Bone: endosteal estimation	0.3	0.7	1.6	0.1	0.8	1.3	0.8	-0.8	1.0
Bone: endosteal perimeter	0.2	0.5	2.3	-1.5	-0.7	0.1	-0.0	0.1	-0.2
Epididymis fat weight	0.0	0.1	0.4	0.7	0.0	-0.2	0.0	-0.0	-0.4
Delta time in closed arm before/after self-admin	0.3	0.3	0.8	-0.7	-0.2	-0.9	0.3	-0.4	0.4
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.5	0.5	0.1	0.4	-0.4	0.4
Diff in mean of infusions in LGA sessions	2.1	2.4	3.2	0.1	-1.3	-1.7	-1.8	1.8	-1.8
Delay discount exponential model param	0.5	0.5	1.8	1.4	0.1	-0.3	-0.6	0.6	-0.6
Extinction: sum of active levers before priming	0.9	0.9	2.0	0.1	0.9	1.4	0.9	-0.9	0.9
Active lever presses in extinction session 6	1.3	1.3	1.9	0.6	1.2	0.4	1.4	-1.4	1.4
Bone: final force	0.7	1.1	2.0	1.2	-0.6	-0.8	-1.0	1.0	-1.4
Bone: final moment	0.8	1.4	2.5	1.4	-0.7	-1.0	-1.1	1.1	-1.6
Food consumed during 24 hour testing period	0.4	0.4	2.1	1.4	0.5	0.4	0.1	-0.1	-0.1
Glucose	1.2	1.8	2.3	0.7	1.4	1.4	1.5	-1.5	1.4
Heart weight	1.0	1.4	3.4	1.9	-0.2	0.0	-1.2	1.2	-1.5
Delay discount hyperbolic model param	0.5	0.5	1.8	1.3	0.1	-0.2	-0.6	0.6	-0.6
Intermittent access intake day 1-15 change	2.7	2.7	4.3	-0.9	-1.8	-0.6	-2.1	2.0	-2.0
Intermittent access intake escalation	2.1	2.1	3.3	-0.8	-1.6	-0.5	-1.8	1.7	-1.7
Intermittent access intake escalation 2	2.4	2.3	3.7	-0.2	-1.5	-1.0	-1.9	1.9	-1.9
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	0.2	-0.1	0.1	-0.3	0.2	-0.2
Intermitt. access day 15 inactive lever presses	1.9	2.1	2.6	-0.7	-1.6	-1.6	-1.6	1.5	-1.5
Intermitt. access escalation Index	0.5	0.4	0.9	0.2	0.5	-0.0	1.0	-0.8	0.8
Intermittent access day 1 total infusions	0.1	0.1	0.1	-0.2	0.1	-0.4	0.0	-0.3	0.3
Intermittent access day 15 total infusions	0.5	0.6	1.1	-0.7	-0.8	-0.5	-1.1	0.8	-0.8
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.5	-0.5	-0.4	-0.3	-0.7	0.3	-0.3
Intermittent access total infusions	0.2	0.2	0.6	-0.8	-0.4	-0.4	-0.6	0.3	-0.3
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.3	0.2	-0.4	0.2	-0.5	0.5
Intermittent access day 15 total locomotion	0.4	0.4	1.3	-1.1	0.1	0.1	0.5	-0.7	0.7
Intermittent access total locomotion	0.5	0.5	1.5	-1.2	0.1	0.0	0.6	-0.8	0.8
Intermittent access standard deviation	2.8	3.0	5.4	0.1	-1.5	-1.6	-2.3	2.0	-2.0
Left kidney weight	1.4	3.9	6.4	1.8	1.9	1.5	2.5	-2.5	1.3
Right kidney weight	1.2	3.3	5.8	0.9	1.7	1.7	2.4	-2.3	1.5
Cocaine induced anxiety	0.5	0.6	0.9	-0.1	-0.7	-0.2	-1.0	1.0	-1.0
Post-drug Anxiety	0.2	0.2	0.3	-0.2	-0.5	-0.2	-0.6	0.6	-0.6
Baseline Anxiety	0.2	0.2	0.8	-0.9	-0.2	0.7	0.1	-0.2	0.2
Tail length	1.7	5.3	19.9	4.5	2.7	1.2	1.0	-1.0	1.0
Length with tail	2.0	7.2	32.7	5.7	2.8	1.1	0.8	-0.7	0.4
Length without tail	1.2	2.6	13.4	3.7	1.4	0.6	-0.0	0.1	-0.3
Times rat made contact with spout	0.2	0.2	0.8	0.9	0.1	-0.2	-0.4	0.4	-0.3
Lifetime Intake	0.1	0.1	0.6	-0.8	-0.2	-0.1	-0.3	-0.0	0.0
Liver weight, left	1.1	1.8	3.2	0.1	1.5	1.6	1.1	-1.1	1.8
Liver weight, right	1.8	3.0	4.0	1.5	2.0	1.8	1.7	-1.7	1.6
Locomotor activity	2.0	3.2	9.7	3.1	2.0	1.9	0.8	-0.8	0.7
Locomotor testing distance	2.0	3.3	8.3	2.9	2.1	2.1	1.0	-1.0	0.8
Locomotor testing rearing	0.0	0.0	0.1	0.2	0.2	0.1	-0.3	0.3	0.1
Locomotion in novel chamber	0.9	1.1	3.5	-0.3	-0.9	-1.9	-0.8	0.8	-0.8
Locomotion in novel chamber post-restriction	0.7	0.9	1.2	0.8	1.1	0.8	1.0	-1.0	1.0
Fecal boli incidents, locomotor time 1	0.1	0.1	0.3	0.6	0.3	0.2	-0.2	0.2	-0.2
Change in fecal boli incidents, locomotor task	0.2	0.2	0.2	0.2	0.3	0.4	0.5	-0.5	0.5
Time >=10cm from walls, locomotor time 1	0.7	0.7	2.0	-0.6	0.5	1.4	0.8	-0.8	0.8
Bouts of movement, locomotor time 1	0.0	0.0	0.1	0.3	-0.0	-0.1	-0.1	0.1	-0.1
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.1	0.1	-0.1
Rest time, locomotor task time 1	0.2	0.2	0.8	-0.9	-0.2	-0.4	0.2	-0.2	0.2
Distance moved, locomotor task time 1	0.5	0.6	1.8	1.3	0.2	0.8	-0.5	0.5	-0.5
Vertical activity count, locomotor time 1	0.5	0.6	1.9	1.0	0.6	1.4	-0.0	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.4	0.5	1.1	1.0	0.8	0.7	0.4	-0.4	0.4
Bouts of movement, locomotor time 2	0.5	0.6	0.9	-0.1	-0.8	-0.9	-0.8	0.8	-0.8
Total resting periods, locomotor time 2	0.5	0.5	0.7	-0.4	-0.8	-0.9	-0.7	0.7	-0.7
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.2	0.1	-0.4	0.4	-0.4	0.4
Distance moved, locomotor task time 2	0.5	0.6	1.5	1.1	0.2	1.2	-0.5	0.5	-0.5
Vertical activity count, locomotor time 2	0.3	0.3	1.6	0.2	0.2	1.3	-0.1	0.1	-0.1
Light reinforcement 1	0.2	0.3	1.1	1.1	0.6	-0.1	0.5	-0.4	0.1
Light reinforcement 2	0.7	0.9	2.1	-0.3	0.5	0.1	1.5	-1.5	0.8
Bone: marrow area	0.4	0.8	1.6	0.2	0.9	1.3	0.8	-0.8	1.0
Bone: maximum diameter	1.2	2.3	3.2	-0.8	-1.7	-1.5	-1.5	1.5	-1.8
Bone: maximum force	0.2	0.4	1.1	1.0	-0.1	-0.3	-0.5	0.5	-0.7
Bone: maximum moment	0.3	0.5	1.3	1.1	-0.2	-0.5	-0.6	0.6	-0.9
Mean time between licks in bursts	0.4	0.5	1.8	-1.3	-0.9	-0.1	-0.4	0.4	-0.4
Mean num. licks in bursts	2.5	3.0	4.2	1.2	1.8	2.0	1.8	-1.8	1.6
Cd content in liver	0.8	0.8	2.0	1.4	0.2	-0.4	-1.1	1.1	-0.4
Co content in liver	0.8	0.9	1.3	-0.2	-1.0	-1.1	-1.0	1.0	-1.1
Cu content in liver	1.8	2.2	4.4	2.1	1.9	1.3	1.0	-1.0	1.3
Fe content in liver	0.5	0.6	1.4	1.2	0.3	-0.1	-1.1	1.1	-0.1
K content in liver	0.9	0.9	1.4	1.1	0.9	0.5	1.2	-1.2	0.5
Mg content in liver	0.3	0.3	0.9	0.2	0.3	0.1	1.0	-1.0	0.1
Mn content in liver	1.9	2.1	2.9	1.0	1.5	1.4	1.7	-1.7	1.4
Na content in liver	0.7	0.7	1.2	0.5	1.1	1.1	0.4	-0.4	1.1
Rb content in liver	0.9	1.1	2.8	0.6	-0.2	-0.5	-1.7	1.7	-0.5
Se content in liver	0.1	0.1	0.2	0.5	0.1	-0.1	0.4	-0.4	-0.1
Sr content in liver	0.3	0.2	0.7	0.3	0.1	0.0	0.8	-0.8	0.0
Zn content in liver	1.8	2.0	5.3	2.3	1.7	0.9	1.1	-1.1	0.9
Bone: minimum diameter	0.3	0.5	0.8	-0.9	-0.9	-0.4	-0.5	0.5	-0.8
Time in familiar zone, hab. session 1	1.9	1.8	2.6	-1.4	-1.4	-1.0	-1.5	1.6	-0.9
Time in novel zone, hab. session 1	0.4	0.4	1.0	1.0	0.6	0.1	0.5	-0.6	0.2
Total zone transitions, hab. session 1	1.3	1.9	3.3	1.0	1.3	1.0	1.8	-1.8	1.0
Total locomotion distance, hab. session 1	0.5	0.7	1.2	0.7	0.8	0.7	1.0	-1.1	0.6
Locomotion velocity, hab. session 1	0.8	1.2	1.9	0.8	1.1	1.0	1.3	-1.4	0.9
Time in familiar zone, hab. session 2	1.8	1.9	2.2	-0.9	-1.5	-1.5	-1.4	1.5	-1.3
Time in novel zone, hab. session 2	0.7	0.7	1.4	0.2	0.9	1.2	0.7	-0.7	1.0
Total zone transitions, hab. session 2	0.3	0.4	1.0	0.4	0.2	0.3	1.0	-0.9	-0.0
Total locomotion distance, hab. session 2	0.6	0.7	1.2	0.8	0.8	0.7	1.1	-1.1	0.5
Locomotion velocity, hab. session 2	0.6	0.8	1.5	0.7	0.8	0.8	1.2	-1.2	0.6
Novel to familiar place preference ratio	6.7	7.0	9.9	0.9	2.7	3.2	2.6	-2.8	3.0
Novelty place preference	7.7	7.9	12.1	0.9	2.9	3.5	2.7	-2.9	3.2
Time in novel zone, NPP test	6.7	6.8	10.7	1.0	2.8	3.3	2.4	-2.6	3.0
Total zone transitions, NPP test	3.4	4.9	7.9	2.1	2.1	1.7	2.8	-2.8	1.4
Total locomotion distance, NPP test	0.9	1.3	2.0	1.4	1.1	1.0	1.2	-1.3	0.6
Locomotion velocity, NPP test	1.4	2.0	2.8	1.5	1.4	1.3	1.5	-1.7	0.9
Intraocular pressure	1.0	1.5	3.9	0.8	1.5	2.0	0.3	-0.3	1.3
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.1	0.3	0.3	0.5	-0.5	0.5
Delta ambulatory time before/after self-admin	0.6	0.6	0.9	0.9	0.9	0.6	0.8	-0.8	0.8
Parametrial fat weight	0.6	1.2	2.3	1.5	1.3	0.5	1.1	-1.1	0.9
Pavlov. Cond. lever latency	2.1	2.6	6.1	2.5	2.1	1.5	0.8	-0.7	1.4
Pavlov. Cond. magazine entry latency	4.0	5.1	8.4	-2.9	-2.7	-2.4	-1.7	1.6	-1.9
Pavlov. Cond. change in total contacts	1.7	1.8	2.4	-1.4	-1.6	-1.4	-1.3	1.3	-1.1
Pavlov. Cond. index score	3.9	5.0	8.1	-2.8	-2.7	-2.3	-1.7	1.6	-1.9
Pavlov. Cond. latency score	3.2	4.0	7.8	-2.8	-2.5	-2.0	-1.3	1.3	-1.6
Pavlov. Cond. lever contacts	1.4	1.6	3.0	-1.7	-1.6	-1.4	-0.6	0.6	-1.1
Pavlov. Cond. magazine entry number	4.0	5.0	9.6	3.1	2.7	2.2	1.7	-1.6	1.7
Pavlov. Cond. intertrial magazine entries	0.3	0.3	0.6	0.5	0.7	0.8	0.4	-0.4	0.5
Pavlov. Cond. lever-magazine prob. diff.	4.6	5.8	8.4	-2.7	-2.9	-2.6	-2.0	1.9	-2.2
Pavlov. Cond. response bias	4.7	5.7	8.5	-2.9	-2.9	-2.6	-1.8	1.8	-2.1
Pavlov. Cond. lever latency	0.1	0.1	0.5	-0.7	-0.1	0.2	-0.3	0.3	0.2
Pavlov. Cond. magazine entry latency	0.3	0.3	0.6	-0.3	-0.7	-0.7	-0.1	0.1	-0.8
Pavlov. Cond. change in total contacts	0.5	0.7	3.2	1.8	0.4	-0.7	0.1	-0.1	-0.4
Pavlov. Cond. index score	0.2	0.3	0.7	0.3	-0.5	-0.8	-0.1	0.1	-0.9
Pavlov. Cond. latency score	0.2	0.2	0.6	0.3	-0.5	-0.7	-0.1	0.1	-0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.4	1.2	0.7	0.4	0.7	-0.7	0.2
Pavlov. Cond. magazine entry number	0.4	0.4	0.8	0.6	0.9	0.8	0.3	-0.3	0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	-0.9	-0.3	0.5	-0.7	0.7	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.8	0.3	-0.5	-0.8	-0.1	0.1	-0.9
Pavlov. Cond. response bias	0.1	0.1	0.3	0.3	-0.3	-0.4	0.1	-0.1	-0.6
Time in closed arm before self-admin	0.3	0.3	1.4	1.2	0.5	0.3	-0.0	0.0	-0.0
Time in closed arm after self-admin	0.2	0.2	0.8	-0.3	-0.4	-0.9	-0.3	0.3	-0.3
Time in open arm before self-admin	0.2	0.3	0.8	-0.9	-0.6	-0.3	-0.3	0.3	-0.3
Time in open arm after self-admin	1.4	1.5	2.5	-0.3	1.0	0.7	1.6	-1.6	1.6
Bone: periosteal estimation	0.1	0.2	0.4	-0.0	-0.5	-0.2	-0.4	0.5	-0.6
Bone: periosteal perimeter	0.7	1.2	2.0	-1.4	-1.4	-0.7	-0.9	0.9	-1.1
Bone: post-yield work	0.0	0.1	0.2	0.2	0.1	-0.0	0.4	-0.4	0.1
Progressive ratio test 1 active lever presses	0.7	0.7	1.0	-0.0	0.8	0.9	0.9	-1.0	1.0
Progressive ratio test 1 breakpoint	0.7	0.7	1.0	-0.1	0.8	0.9	0.9	-1.0	1.0
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.2	-0.5	-1.0	-0.8	-1.1	1.0	-1.0
Progressive ratio test 2 active lever presses	0.2	0.2	0.8	-0.9	-0.4	-0.2	-0.4	0.1	-0.1
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	-0.7	-0.4	-0.3	-0.5	0.2	-0.2
Progressive ratio test 2 inactive lever presses	3.3	3.8	5.4	-1.2	-2.2	-1.5	-2.3	2.1	-2.1
Incentive Sensitization - Responses	1.1	1.2	1.5	-1.1	-1.2	-1.1	-1.1	1.0	-1.0
Incentive Sensitization - Breakpoint	1.1	1.1	1.5	-1.1	-1.2	-1.0	-1.1	1.0	-1.0
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.9	0.9	0.9	0.6	0.7	-0.7	0.7
Progressive ratio	2.1	2.4	4.6	2.1	1.8	1.8	1.1	-1.1	1.1
Food seeking constrained by brief footshock	0.4	0.5	0.9	-0.9	-0.9	-0.7	-0.4	0.4	-0.4
Seeking ratio, punishment vs. effort	2.9	3.6	7.1	-2.7	-2.3	-1.5	-1.5	1.5	-1.5
Retroperitoneal fat weight	0.3	1.1	1.5	1.0	1.2	0.9	1.1	-1.1	0.8
Reaction time number correct	0.4	0.6	1.0	-1.0	-0.9	-0.6	-0.8	0.8	-0.4
Reaction time mean minus median	0.2	0.2	0.5	0.4	0.4	0.1	0.7	-0.7	0.2
Reaction time mean minus median AUC	0.4	0.5	0.7	0.7	0.7	0.2	0.8	-0.8	0.6
Reaction time num false alarms	0.4	0.6	2.8	-0.7	0.1	1.7	-0.2	0.2	0.2
Reaction time num false alarms AUC	0.7	0.9	4.6	-0.3	0.6	2.1	0.2	-0.2	0.6
Reaction time trials correct on left	0.4	0.6	1.0	-1.0	-0.9	-0.6	-0.8	0.8	-0.4
Reaction time trials on left	0.4	0.6	1.1	-1.0	-0.8	-0.5	-0.8	0.7	-0.4
Reaction time mean	0.2	0.2	0.8	-0.1	0.4	0.9	0.4	-0.4	0.5
Reaction time mean AUC	0.3	0.5	1.0	-0.1	0.6	1.0	0.6	-0.6	0.7
Median of all reaction times	0.2	0.3	1.1	-0.2	0.4	1.1	0.2	-0.2	0.5
Reaction time omissions	0.2	0.3	0.6	-0.8	-0.1	0.7	-0.6	0.6	0.2
Reaction time false alarm rate	0.5	0.8	3.9	-0.0	0.6	2.0	0.2	-0.2	0.5
Reaction time premature initiation rate	0.8	1.0	3.7	1.9	1.1	-0.2	0.7	-0.7	0.5
Reaction time premature initiations	0.3	0.4	1.7	1.3	0.5	-0.5	0.2	-0.2	0.1
Std. dev. reaction times	0.6	0.8	1.0	0.3	0.9	1.0	1.0	-1.0	0.9
Reaction time trials completed	0.4	0.6	1.1	-1.0	-0.8	-0.5	-0.8	0.7	-0.4
Reaction time trials AUC	0.4	0.6	1.3	-1.2	-0.9	-0.5	-0.8	0.7	-0.4
Run reversals in cocaine runway, females	1.3	1.3	2.9	-1.7	-1.4	0.0	-1.0	1.0	-1.0
Run reversals in cocaine runway, males	0.5	0.5	0.7	0.8	-0.1	0.4	-0.8	0.8	-0.8
Latency to leave start box in cocaine runway	0.1	0.1	0.6	0.7	0.3	-0.2	-0.0	0.0	-0.0
Latency to leave start box in cocaine runway, F	0.7	0.8	1.4	1.2	-0.2	-0.2	-1.0	1.0	-1.0
Latency to leave start box in cocaine runway, M	0.7	0.7	1.2	-0.3	0.6	-0.2	1.1	-1.1	1.1
Std. dev. time between licks in bursts	4.8	5.7	8.1	-2.5	-2.8	-2.0	-2.3	2.3	-2.3
Total sessions with >9 infusions	1.4	1.5	2.2	-0.5	-1.2	-1.5	-1.4	1.2	-1.2
Short access day 1 total inactive lever presses	2.3	2.6	6.8	-2.6	-1.9	-0.8	-1.4	1.2	-1.2
Short access day 10 total inactive lever presses	3.1	3.4	5.7	0.3	-1.6	-2.4	-2.1	2.0	-2.0
Short access day 1 total infusions	0.7	0.7	1.5	-1.2	-0.9	-1.0	-0.7	0.5	-0.5
Short access day 10 total infusions	0.1	0.1	0.1	-0.4	0.2	0.4	0.1	-0.4	0.4
Short access total infusions	0.2	0.3	1.2	-1.1	-0.1	-0.0	0.1	-0.4	0.4
Short access day 1 locomotion	0.3	0.4	2.0	-0.1	-0.3	-1.4	-0.3	-0.0	0.0
Short access day 10 total locomotion	0.6	0.7	1.3	0.0	0.8	0.5	0.9	-1.1	1.1
Short access total locomotion	0.8	0.9	1.5	0.0	0.9	0.6	1.0	-1.2	1.2
One hour access (0.3 mA shock)	0.2	0.3	0.5	-0.6	0.2	-0.0	0.5	-0.7	0.7
Compulsive drug intake	0.9	0.9	1.9	-0.4	0.6	0.2	1.4	-1.2	1.2
One hour access (shock baseline)	0.1	0.1	0.6	-0.1	-0.2	0.0	-0.8	0.3	-0.3
Social response proportion	0.1	0.1	0.4	0.6	0.2	-0.4	-0.2	0.2	0.2
Social responses	0.3	0.4	0.6	0.8	0.7	0.6	0.5	-0.5	0.5
Social time	2.1	2.8	4.2	-0.8	-1.8	-2.0	-1.6	1.6	-1.9
Soleus weight	0.8	2.3	11.7	3.4	1.3	0.1	0.6	-0.5	-0.2
Bone: stiffness	0.0	0.0	0.1	0.4	0.1	0.2	-0.1	0.1	-0.0
Tibialis anterior weight	0.1	0.4	0.8	0.1	-0.6	-0.8	-0.6	0.5	-0.9
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.6	1.3	0.9	0.7	0.3	-0.4	0.4
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.3	1.0	-0.2	0.8	-1.1	1.1	-1.1
Time to tail flick, test, before self-admin	1.8	1.7	2.5	0.4	1.3	1.0	1.6	-1.6	1.6
Time to tail flick, test, after self-admin	0.3	0.4	0.6	-0.0	-0.6	-0.4	-0.7	0.8	-0.8
Delta time to tail flick, vehicle, before/after SA	1.2	1.2	1.9	-0.5	-1.1	-0.1	-1.4	1.4	-1.4
Delta time to tail flick, test, before/after SA	0.9	0.8	1.0	-0.5	-1.0	-0.8	-1.0	1.0	-1.0
Tibia length	1.9	5.5	21.9	4.7	2.1	0.2	1.8	-1.7	0.2
Ambulatory time before self-admin	1.0	1.1	1.4	-0.6	-1.1	-0.9	-1.2	1.2	-1.2
Ambulatory time after self-admin	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.2	-0.2	0.2
Bone: tissue strength	1.0	1.0	2.5	1.6	-0.1	-1.1	-0.8	0.8	-1.0
Total heroin consumption	0.5	0.6	1.9	1.4	0.2	0.8	-0.6	0.6	-0.6
Bone: trabecular number	1.1	1.7	2.3	-0.9	0.7	1.5	1.5	-1.5	1.5
Bone: trabecular spacing	1.4	1.8	2.6	1.2	-0.7	-1.6	-1.4	1.4	-1.5
Bone: trabecular thickness	1.5	1.8	2.6	0.3	1.2	1.5	1.6	-1.6	1.3
Bone: trabecular tissue density	0.2	0.4	0.5	0.6	0.7	0.4	0.6	-0.6	0.6
Water consumed over 24 hours	1.2	1.4	2.1	0.1	-1.1	-1.4	-1.2	1.2	-1.5
Number of responses in last shaping day	1.0	1.0	1.3	-0.8	-1.2	-0.9	-1.1	1.0	-1.0