Hub : Genes

Arhgap35

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain isoform ratio NM_001271132.1 0.03 0.02 3.0e-03 0.02 0.02 0.02 0.02 7.0e-03 5.8e-03 2.7e-03 7.6e-03
2 LHb mRNA stability Arhgap35 0.29 0.18 3.6e-06 0.28 0.26 0.28 0.28 2.9e-07 8.2e-07 2.9e-07 2.7e-07
3 Brain gene expression Arhgap35 0.18 0.14 1.5e-06 0.05 0.06 0.05 0.05 1.0e-05 4.7e-06 1.5e-05 1.3e-05
4 NAcc isoform ratio XM_008758919.3 0.02 0.02 5.2e-03 0.01 0.01 0.01 0.01 2.0e-02 4.2e-03 2.3e-03 4.2e-03
5 Brain isoform ratio XM_039110038.2 0.04 0.05 1.4e-03 0.03 0.03 0.02 0.02 2.1e-03 1.7e-03 2.4e-03 3.2e-03
6 Adipose gene expression Arhgap35 0.22 0.12 0.0e+00 0.25 0.24 0.24 0.24 3.4e-27 3.4e-26 1.2e-26 1.8e-26
7 Brain mRNA stability Arhgap35 0.03 0.03 4.6e-03 0.02 0.02 -0 0.01 1.1e-02 1.0e-02 4.1e-01 1.4e-02
8 Liver isoform ratio NM_001271132.1 0.02 0.02 2.9e-03 0.02 0.02 0.02 0.02 2.5e-03 1.9e-03 5.0e-03 4.2e-03
9 Brain intron excision ratio chr1_86396345_86446913 0.03 0.03 1.5e-03 0.03 0.03 0.02 0.02 2.0e-03 8.3e-04 9.7e-03 2.8e-03
10 Liver gene expression Arhgap35 0.08 0.06 3.3e-10 0.07 0.07 0.06 0.06 8.4e-08 4.5e-08 1.1e-07 1.6e-07
11 Adipose isoform ratio NM_001271132.1 0.02 0.03 8.1e-03 0.01 0.02 0.01 0.01 6.7e-03 4.7e-03 4.9e-02 7.0e-03
12 NAcc isoform ratio XM_039110038.2 0.03 0.03 6.0e-04 0.02 0.02 0.02 0.02 4.7e-04 4.7e-04 4.7e-04 5.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.10.70.10.20.8-0.30.4-0.2-0.2-0.1-0.10.1-0.10.6
Area under the delay curve0.61.02.0-1.31.4-1.2-1.1-1.00.90.90.80.8-0.80.80.2
BMI with tail1.24.25.12.3-2.21.92.22.0-2.0-2.0-2.0-2.02.0-2.0-1.8
BMI without tail1.15.86.72.5-2.52.12.62.3-2.4-2.4-2.4-2.42.4-2.4-2.4
Body weight2.29.612.03.5-3.22.93.43.1-3.0-3.1-3.1-3.13.1-3.1-2.7
Weight adjusted by age0.10.31.00.5-0.5-0.10.70.3-0.3-0.4-0.4-0.40.5-0.5-1.0
Bone surface0.51.02.11.1-0.81.50.71.1-1.0-1.0-1.0-1.00.9-0.9-0.2
Bone volume0.20.51.70.7-0.41.30.30.9-0.8-0.7-0.7-0.60.6-0.60.2
Breakpoint value in progressive ratio session1.93.46.3-1.81.6-2.5-1.4-2.12.01.91.91.9-1.81.80.9
Number of licking bursts1.44.25.22.3-2.02.02.22.1-2.0-2.0-2.0-2.02.0-2.0-1.7
Context. condit. distance diff. score0.00.00.10.1-0.10.30.10.2-0.2-0.2-0.2-0.20.1-0.2-0.1
Locomotion velocity, session 10.40.41.0-0.70.7-0.0-1.0-0.40.60.50.50.5-0.60.51.0
Locomotion distance, session 10.00.00.2-0.10.10.1-0.3-0.10.20.10.20.2-0.20.20.4
Locomotion velocity, session 21.82.22.71.6-1.61.61.51.5-1.5-1.5-1.5-1.51.4-1.4-1.1
Locomotion distance, session 20.50.70.80.9-0.90.70.90.8-0.7-0.8-0.8-0.80.8-0.8-0.9
Locomotion velocity, session 30.20.30.60.4-0.20.80.20.6-0.6-0.6-0.6-0.60.5-0.6-0.3
Locomotion distance, session 30.91.02.0-1.31.4-1.0-1.3-1.00.90.90.90.9-0.90.90.5
Stereotopy head waving bouts, day 30.81.01.51.1-1.01.20.91.1-0.9-1.0-1.0-1.00.9-1.0-0.5
Stereotopy head waving duration, day 30.60.71.11.1-1.01.00.90.9-0.8-0.8-0.8-0.80.8-0.8-0.3
Locomotion velocity, session 70.91.01.8-1.01.1-0.5-1.2-0.80.90.90.90.9-1.00.91.3
Locomotion distance, session 70.00.00.2-0.00.20.5-0.20.2-0.2-0.1-0.1-0.10.0-0.10.4
Stereotopy head waving bouts, day 70.50.60.70.7-0.40.90.60.8-0.7-0.8-0.8-0.80.8-0.8-0.8
Stereotopy head waving duration, day 70.50.60.70.7-0.60.90.60.8-0.7-0.8-0.8-0.80.8-0.8-0.8
Locomotion velocity, session 80.00.10.2-0.20.30.1-0.4-0.10.10.20.20.2-0.20.20.4
Locomotion distance, session 80.00.00.10.1-0.20.00.20.1-0.1-0.1-0.1-0.10.1-0.1-0.3
Degree of sensitization distance0.70.81.61.0-1.01.30.81.0-0.9-0.9-0.8-0.80.8-0.8-0.1
Degree of sensitization stereotypy0.60.71.20.8-0.50.80.70.8-0.8-0.9-0.9-0.90.9-0.9-1.1
Conditioned locomotion0.20.20.7-0.50.3-0.9-0.2-0.50.40.40.30.3-0.30.3-0.3
Cocaine response after cond. corrected0.20.30.50.6-0.50.70.40.7-0.6-0.6-0.6-0.60.6-0.6-0.4
Cocaine response after cond. not corrected0.91.21.41.2-1.21.21.11.2-1.1-1.1-1.1-1.11.1-1.1-0.9
Cocaine response before conditioning2.22.73.71.9-1.91.51.91.6-1.5-1.6-1.6-1.61.6-1.6-1.5
Saline control response1.21.72.21.3-1.11.51.21.4-1.4-1.4-1.3-1.31.3-1.3-1.0
Bone: connectivity density0.00.10.30.2-0.10.50.00.3-0.3-0.2-0.2-0.20.2-0.20.1
Bone: cortical apparent density0.10.10.3-0.40.5-0.1-0.4-0.20.20.30.30.3-0.30.30.4
Bone: cortical area1.72.84.31.9-1.72.11.51.8-1.7-1.7-1.7-1.61.6-1.6-0.9
Bone: cortical porosity0.10.10.5-0.1-0.1-0.70.2-0.40.40.40.30.3-0.30.3-0.1
Bone: cortical porosity0.10.10.40.4-0.5-0.30.60.0-0.1-0.1-0.1-0.10.2-0.1-0.6
Bone: cortical thickness0.50.81.81.1-1.01.40.71.0-0.9-0.9-0.9-0.80.8-0.8-0.1
Bone: cortical thickness0.81.02.21.0-0.91.50.71.2-1.0-1.1-1.0-1.01.0-1.0-0.4
Bone: cortical tissue density0.10.20.4-0.60.6-0.2-0.5-0.30.30.40.40.4-0.40.40.4
Condit. Reinf. active minus inactive responses0.91.11.11.1-1.01.01.01.0-1.0-1.0-1.0-1.01.0-1.1-1.0
Condit. Reinf. active-inactive response ratio1.01.01.41.0-1.00.81.11.0-0.9-1.0-1.0-1.01.0-1.0-1.2
Condit. Reinf. active responses0.50.60.80.8-0.70.90.70.9-0.8-0.8-0.8-0.80.8-0.8-0.6
Condit. Reinf. inactive responses0.20.20.7-0.40.60.1-0.6-0.20.20.30.30.4-0.40.40.8
Incentive salience index mean0.71.01.11.0-0.91.10.91.0-0.9-1.0-1.0-1.01.0-1.0-0.8
Condit. Reinf. lever presses0.20.40.60.7-0.50.80.50.7-0.6-0.6-0.6-0.60.6-0.6-0.4
Condit. Reinf. active minus inactive responses0.00.00.20.00.20.4-0.20.2-0.1-0.1-0.1-0.10.0-0.10.3
Condit. Reinf. active-inactive response ratio0.10.10.40.10.20.6-0.20.3-0.3-0.2-0.2-0.20.1-0.20.4
Condit. Reinf. active responses0.10.10.2-0.40.4-0.2-0.4-0.30.30.30.30.3-0.30.30.4
Condit. Reinf. inactive responses0.30.40.6-0.70.5-0.8-0.5-0.70.80.70.70.7-0.60.60.3
Condit. Reinf. lever presses0.10.20.50.4-0.50.10.60.3-0.3-0.4-0.4-0.40.4-0.5-0.7
Condit. Reinf. lever reinforcers received0.10.10.2-0.40.4-0.2-0.4-0.30.40.30.30.3-0.30.30.3
Conditioned reinforcement - actives1.14.35.32.3-2.32.12.22.1-2.0-2.0-2.0-2.02.0-2.0-1.6
Conditioned reinforcement - inactives1.13.14.52.0-1.82.11.81.9-1.8-1.8-1.7-1.71.7-1.7-1.1
Conditioned locomotion1.52.33.41.8-1.71.61.81.5-1.3-1.5-1.4-1.41.4-1.4-1.1
Patch foraging indifference point 0 sec0.20.50.80.7-0.50.90.60.8-0.7-0.7-0.7-0.70.7-0.6-0.5
Patch foraging indifference point AUC2.56.06.62.5-2.12.62.42.6-2.5-2.5-2.5-2.52.5-2.5-2.2
Delay disc. indifference point, 0s delay0.40.40.7-0.60.8-0.5-0.7-0.60.60.60.60.6-0.70.60.7
Delay disc. indifference point, 16s delay0.20.30.7-0.70.9-0.8-0.5-0.60.50.50.50.5-0.50.5-0.1
Delay disc. indifference point, 2s delay1.71.93.1-1.81.6-1.6-1.6-1.41.41.31.31.3-1.21.20.6
Delay disc. indifference point, 24s delay0.10.10.70.1-0.2-0.40.3-0.0-0.0-0.1-0.2-0.20.2-0.2-0.8
Delay disc. indifference point, 4s delay0.10.10.20.1-0.00.5-0.00.5-0.4-0.5-0.4-0.40.4-0.4-0.4
Delay disc. indifference point, 8s delay1.11.93.6-1.61.9-1.5-1.5-1.31.21.31.21.2-1.21.20.6
Indifference point function ln k1.13.23.9-2.01.6-1.5-2.0-1.71.81.81.81.8-1.81.91.7
Indifference point function log k1.13.23.9-2.01.6-1.5-2.0-1.71.81.81.81.8-1.81.91.7
Patch foraging total patch changes 0 sec0.20.61.00.8-0.71.00.70.9-0.8-0.8-0.8-0.80.7-0.7-0.6
Patch foraging total patch changes 12 sec2.33.03.51.8-1.31.91.81.8-1.8-1.8-1.8-1.81.8-1.8-1.5
Patch foraging total patch changes 18 sec1.33.03.81.9-1.42.01.61.9-1.8-1.8-1.8-1.81.7-1.7-1.3
Patch foraging total patch changes 24 sec0.61.92.61.6-1.41.11.61.3-1.3-1.3-1.4-1.41.4-1.4-1.5
Patch foraging total patch changes 6 sec2.13.54.51.9-1.62.11.82.0-1.8-1.9-1.9-1.91.9-1.9-1.5
Patch foraging time to switch 0 sec0.93.44.6-1.81.6-2.1-1.6-2.01.91.91.91.9-1.91.91.5
Patch foraging water rate 0 sec1.24.45.82.2-2.12.42.02.2-2.1-2.1-2.1-2.12.1-2.1-1.5
Patch foraging water rate 12 sec0.00.10.20.4-0.30.50.20.3-0.2-0.2-0.2-0.20.2-0.20.1
Patch foraging water rate 18 sec0.00.00.20.3-0.30.40.10.3-0.2-0.2-0.2-0.20.1-0.10.1
Patch foraging water rate 24 sec0.00.00.10.10.10.4-0.20.2-0.1-0.1-0.1-0.00.0-0.00.3
Patch foraging water rate 6 sec0.81.21.81.2-1.30.71.31.0-1.0-1.0-1.1-1.11.1-1.1-1.3
Seeking ratio, delayed vs. immediate footshock2.02.94.3-2.01.9-1.3-2.1-1.61.61.61.61.6-1.71.61.6
Distance traveled before self-admin0.00.00.0-0.10.00.0-0.0-0.00.1-0.0-0.0-0.00.0-0.0-0.1
Distance traveled after self-admin0.61.11.5-1.21.1-1.1-1.0-1.11.11.01.01.0-1.01.00.6
Extensor digitorum longus weight2.39.011.03.3-3.03.23.03.1-3.1-3.0-3.0-3.02.9-2.9-2.3
Bone: elastic displacement0.81.01.9-1.01.1-0.6-1.2-0.90.91.01.01.0-1.01.01.4
Bone: elastic work0.10.20.60.5-0.10.80.10.5-0.4-0.4-0.3-0.30.2-0.30.4
Bone: endosteal estimation0.00.00.1-0.10.30.0-0.20.0-0.0-0.00.00.0-0.0-0.00.0
Bone: endosteal perimeter0.10.10.30.3-0.10.60.10.4-0.3-0.4-0.4-0.40.4-0.4-0.1
Epididymis fat weight0.10.41.6-0.50.60.0-0.8-0.40.60.50.60.6-0.60.61.3
Delta time in closed arm before/after self-admin0.50.50.8-0.80.9-0.6-0.8-0.70.70.70.70.7-0.70.70.5
Delta time in open arm before/after self-admin0.20.30.60.6-0.80.30.60.5-0.4-0.5-0.5-0.50.5-0.5-0.4
Diff in mean of infusions in LGA sessions1.62.93.8-1.82.0-1.9-1.8-1.71.71.71.61.6-1.61.61.2
Delay discount exponential model param0.50.71.61.1-1.31.01.00.8-0.7-0.7-0.7-0.70.6-0.7-0.0
Extinction: sum of active levers before priming0.00.00.00.0-0.1-0.10.1-0.10.10.10.10.1-0.10.10.0
Active lever presses in extinction session 60.70.73.10.6-0.8-0.11.00.5-0.5-0.6-0.7-0.80.8-0.8-1.7
Bone: final force0.71.11.41.2-1.11.11.01.1-1.0-1.0-1.0-1.01.0-1.0-0.8
Bone: final moment0.91.52.01.4-1.31.41.21.3-1.2-1.3-1.2-1.21.2-1.2-0.8
Food consumed during 24 hour testing period3.16.37.7-2.62.2-2.8-2.2-2.72.72.62.62.6-2.52.61.9
Glucose1.01.63.2-1.41.7-0.6-1.8-1.01.11.11.11.1-1.21.11.7
Heart weight1.22.02.51.6-1.51.51.51.4-1.4-1.4-1.4-1.31.3-1.3-1.1
Delay discount hyperbolic model param0.50.61.41.1-1.20.90.90.7-0.7-0.6-0.6-0.60.6-0.60.0
Intermittent access intake day 1-15 change0.00.30.60.6-0.40.80.30.6-0.6-0.5-0.5-0.50.5-0.50.0
Intermittent access intake escalation0.10.50.90.7-0.60.90.50.8-0.8-0.7-0.7-0.70.7-0.7-0.2
Intermittent access intake escalation 20.00.10.2-0.30.4-0.0-0.4-0.20.20.20.20.2-0.20.20.4
Intermitt. access day 1 inactive lever presses0.00.60.80.7-0.70.60.90.7-0.7-0.8-0.7-0.70.8-0.8-0.9
Intermitt. access day 15 inactive lever presses0.10.60.90.8-0.70.50.90.7-0.6-0.7-0.7-0.70.8-0.8-0.9
Intermitt. access escalation Index0.10.41.3-0.70.6-1.1-0.3-0.80.70.60.60.6-0.50.50.0
Intermittent access day 1 total infusions1.34.05.62.3-2.02.41.82.2-2.1-2.0-2.0-2.01.9-1.9-1.2
Intermittent access day 15 total infusions0.71.82.91.6-1.31.71.11.5-1.5-1.3-1.3-1.31.3-1.3-0.6
Intermittent access terminal intake (last 3 days)0.81.52.81.4-1.21.71.01.4-1.3-1.2-1.2-1.21.1-1.1-0.4
Intermittent access total infusions2.63.14.32.0-1.82.11.61.9-1.9-1.8-1.7-1.71.7-1.7-1.1
Intermittent access day 1 locomotion0.51.02.01.3-1.11.40.91.1-0.9-1.0-0.9-0.90.8-0.8-0.1
Intermittent access day 15 total locomotion0.10.41.20.8-0.61.10.30.7-0.6-0.6-0.5-0.50.4-0.40.5
Intermittent access total locomotion1.92.34.91.8-1.62.21.21.7-1.5-1.5-1.4-1.41.3-1.3-0.2
Intermittent access standard deviation0.10.30.6-0.60.8-0.6-0.7-0.60.50.60.50.5-0.60.60.4
Left kidney weight3.427.332.95.7-5.55.35.45.3-5.2-5.2-5.2-5.25.1-5.1-4.3
Right kidney weight3.323.427.35.2-5.05.14.85.0-4.9-4.9-4.8-4.84.8-4.8-3.9
Cocaine induced anxiety0.00.10.2-0.30.30.1-0.4-0.10.20.20.20.2-0.30.30.5
Post-drug Anxiety0.10.10.3-0.30.3-0.1-0.4-0.20.30.30.30.3-0.30.30.5
Baseline Anxiety0.50.91.0-1.00.9-0.9-1.0-0.90.90.90.90.9-0.90.91.0
Tail length0.84.25.52.3-2.01.72.31.9-2.1-2.0-2.0-2.02.0-2.0-2.1
Length with tail0.83.34.42.1-1.71.92.01.9-1.9-1.8-1.8-1.81.8-1.8-1.5
Length without tail0.31.52.31.5-1.31.51.31.3-1.2-1.2-1.2-1.21.1-1.2-0.6
Times rat made contact with spout0.30.40.5-0.70.7-0.4-0.7-0.50.60.60.60.6-0.60.60.7
Lifetime Intake2.93.64.82.2-1.92.11.82.0-2.0-1.9-1.9-1.91.8-1.8-1.2
Liver weight, left3.15.47.62.3-2.61.72.62.1-2.1-2.2-2.3-2.32.3-2.3-2.8
Liver weight, right2.03.53.81.9-1.71.71.81.9-1.9-1.9-1.9-1.91.9-1.9-2.0
Locomotor activity2.03.14.12.0-1.81.52.01.7-1.7-1.7-1.7-1.71.7-1.7-1.7
Locomotor testing distance1.22.94.02.0-2.01.42.01.6-1.5-1.6-1.6-1.61.6-1.6-1.7
Locomotor testing rearing2.910.512.83.6-3.43.13.53.2-3.1-3.2-3.2-3.23.2-3.2-2.9
Locomotion in novel chamber1.11.52.2-1.31.2-0.8-1.5-1.11.11.11.21.2-1.21.21.5
Locomotion in novel chamber post-restriction0.51.52.1-1.41.1-1.3-1.4-1.21.21.21.21.2-1.11.11.0
Fecal boli incidents, locomotor time 10.10.41.30.6-0.61.20.20.7-0.5-0.6-0.5-0.50.5-0.50.2
Change in fecal boli incidents, locomotor task0.80.91.5-1.01.2-1.1-0.8-1.00.70.90.90.9-0.90.90.6
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.30.1-0.20.00.2-0.00.00.0-0.00.00.2
Bouts of movement, locomotor time 13.04.05.5-2.22.4-2.3-1.9-2.12.02.01.91.9-1.91.91.2
Total resting periods, locomotor time 14.04.66.2-2.52.5-2.2-2.3-2.22.12.12.12.1-2.12.11.6
Rest time, locomotor task time 10.20.40.9-0.70.7-0.1-0.9-0.40.50.40.50.5-0.50.50.9
Distance moved, locomotor task time 10.41.12.51.1-1.20.41.40.7-0.9-0.8-0.9-0.91.0-0.9-1.6
Vertical activity count, locomotor time 10.00.30.60.6-0.60.10.80.3-0.5-0.4-0.4-0.40.5-0.4-0.8
Time >=10cm from walls, locomotor time 20.00.00.20.0-0.40.30.10.2-0.1-0.2-0.1-0.10.1-0.1-0.0
Bouts of movement, locomotor time 22.27.311.7-2.72.8-3.4-2.2-3.02.92.82.72.7-2.62.71.4
Total resting periods, locomotor time 21.87.110.2-2.72.8-3.2-2.3-2.92.92.72.72.7-2.62.61.6
Rest time, locomotor task time 20.50.82.6-0.80.7-0.1-1.2-0.60.80.70.80.8-0.90.81.6
Distance moved, locomotor task time 21.11.53.41.2-1.10.51.60.9-1.2-1.0-1.1-1.11.2-1.1-1.8
Vertical activity count, locomotor time 20.10.31.20.3-0.3-0.30.80.1-0.5-0.2-0.3-0.40.4-0.4-1.1
Light reinforcement 10.10.51.30.8-1.20.11.10.4-0.4-0.6-0.6-0.60.6-0.6-1.1
Light reinforcement 20.61.32.31.2-1.50.71.50.9-1.0-1.0-1.0-1.01.1-1.0-1.3
Bone: marrow area0.00.00.0-0.00.20.1-0.10.1-0.1-0.1-0.1-0.10.1-0.1-0.1
Bone: maximum diameter2.55.06.32.5-2.42.02.52.2-2.2-2.2-2.2-2.22.2-2.2-2.1
Bone: maximum force0.30.60.80.9-0.80.90.70.8-0.7-0.8-0.8-0.70.7-0.7-0.4
Bone: maximum moment0.40.81.41.1-0.91.20.81.0-0.9-0.9-0.9-0.90.9-0.9-0.4
Mean time between licks in bursts0.00.00.10.1-0.2-0.30.2-0.10.00.00.0-0.00.0-0.0-0.3
Mean num. licks in bursts2.36.17.6-2.82.5-2.3-2.7-2.52.52.42.52.5-2.52.42.2
Cd content in liver0.40.41.0-0.60.5-0.3-0.7-0.60.70.60.70.7-0.70.71.0
Co content in liver1.01.21.4-1.21.1-1.1-1.1-1.11.11.11.11.1-1.01.10.8
Cu content in liver0.50.60.80.7-0.70.60.80.7-0.8-0.7-0.7-0.70.7-0.7-0.9
Fe content in liver3.44.24.62.1-2.02.12.02.1-2.1-2.0-2.1-2.12.0-2.0-1.9
K content in liver0.30.30.70.5-0.50.30.50.5-0.6-0.6-0.6-0.60.6-0.6-0.8
Mg content in liver0.91.02.10.9-1.20.41.20.8-0.8-0.9-0.9-0.91.0-0.9-1.5
Mn content in liver0.80.91.10.9-0.91.10.81.0-1.0-1.0-1.0-1.01.0-1.0-0.8
Na content in liver0.00.00.0-0.20.0-0.1-0.2-0.1-0.10.10.00.0-0.00.1-0.2
Rb content in liver0.00.00.10.1-0.30.00.20.1-0.1-0.2-0.2-0.20.2-0.2-0.4
Se content in liver5.76.711.02.5-2.71.82.82.3-2.5-2.5-2.6-2.62.6-2.6-3.3
Sr content in liver0.10.10.20.4-0.10.40.30.3-0.3-0.3-0.3-0.20.2-0.2-0.1
Zn content in liver2.32.73.81.7-2.01.11.91.5-1.5-1.6-1.6-1.61.6-1.6-1.9
Bone: minimum diameter0.30.61.30.7-0.41.20.40.9-0.8-0.8-0.8-0.80.8-0.8-0.3
Time in familiar zone, hab. session 10.20.20.60.6-0.50.80.30.5-0.3-0.4-0.3-0.30.2-0.20.5
Time in novel zone, hab. session 10.70.82.10.8-0.60.51.00.7-0.8-0.8-0.9-0.90.9-0.9-1.5
Total zone transitions, hab. session 10.00.00.20.2-0.10.40.00.2-0.1-0.2-0.2-0.20.1-0.10.2
Total locomotion distance, hab. session 10.40.50.7-0.80.8-0.6-0.8-0.70.80.70.70.7-0.70.70.8
Locomotion velocity, hab. session 11.21.61.9-1.41.3-1.1-1.4-1.31.31.31.31.3-1.31.31.2
Time in familiar zone, hab. session 20.50.51.60.9-0.71.30.50.9-0.7-0.7-0.6-0.60.5-0.60.5
Time in novel zone, hab. session 20.40.51.8-0.80.6-1.3-0.3-0.80.70.60.50.5-0.40.5-0.7
Total zone transitions, hab. session 20.40.60.90.9-0.90.90.70.8-0.7-0.7-0.7-0.70.7-0.7-0.3
Total locomotion distance, hab. session 20.50.60.8-0.80.7-0.7-0.9-0.80.80.80.80.8-0.80.80.8
Locomotion velocity, hab. session 20.30.30.5-0.60.6-0.4-0.7-0.50.60.50.60.6-0.60.60.6
Novel to familiar place preference ratio0.50.71.10.6-0.80.70.70.8-0.8-0.8-0.8-0.80.8-0.8-1.0
Novelty place preference0.40.50.90.6-0.70.60.60.7-0.7-0.7-0.7-0.70.7-0.7-0.9
Time in novel zone, NPP test0.50.60.90.6-0.70.70.60.8-0.7-0.8-0.8-0.80.8-0.8-0.9
Total zone transitions, NPP test0.10.20.40.6-0.60.40.60.4-0.3-0.4-0.4-0.40.4-0.4-0.3
Total locomotion distance, NPP test0.00.00.10.3-0.20.20.20.2-0.1-0.2-0.2-0.20.2-0.2-0.1
Locomotion velocity, NPP test0.00.00.10.3-0.20.20.20.2-0.1-0.2-0.2-0.20.2-0.2-0.2
Intraocular pressure0.10.10.3-0.30.40.0-0.5-0.20.30.30.30.3-0.30.30.6
Delta distance traveled before/after self-admin0.91.01.7-1.11.0-1.3-0.9-1.11.01.01.01.0-0.91.00.5
Delta ambulatory time before/after self-admin0.20.30.4-0.60.5-0.6-0.5-0.50.40.50.50.5-0.50.50.3
Parametrial fat weight0.00.10.5-0.00.10.7-0.30.3-0.3-0.2-0.1-0.10.1-0.10.5
Pavlov. Cond. lever latency0.60.81.0-0.91.0-0.7-0.9-0.80.80.90.90.9-0.90.91.0
Pavlov. Cond. magazine entry latency0.40.51.00.8-1.00.31.00.5-0.5-0.6-0.6-0.60.7-0.7-1.0
Pavlov. Cond. change in total contacts0.30.30.6-0.70.4-0.8-0.5-0.70.70.60.60.6-0.50.50.2
Pavlov. Cond. index score0.50.71.20.9-1.10.41.00.7-0.6-0.7-0.8-0.80.8-0.8-1.1
Pavlov. Cond. latency score0.20.30.60.6-0.80.10.70.3-0.3-0.4-0.5-0.50.5-0.5-0.8
Pavlov. Cond. lever contacts0.40.50.70.8-0.80.60.80.7-0.6-0.7-0.7-0.70.7-0.7-0.8
Pavlov. Cond. magazine entry number0.20.30.6-0.50.7-0.1-0.7-0.30.30.40.50.5-0.50.50.8
Pavlov. Cond. intertrial magazine entries0.00.00.30.00.10.3-0.30.1-0.0-0.00.00.0-0.10.10.6
Pavlov. Cond. lever-magazine prob. diff.0.60.71.30.9-1.10.51.10.7-0.7-0.8-0.8-0.80.9-0.8-1.1
Pavlov. Cond. response bias1.41.82.21.4-1.51.11.51.2-1.2-1.3-1.3-1.31.4-1.3-1.5
Pavlov. Cond. lever latency0.10.20.2-0.40.5-0.4-0.4-0.40.30.40.40.4-0.40.40.4
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.2-0.20.2-0.00.0-0.0-0.0-0.10.1-0.1-0.2
Pavlov. Cond. change in total contacts0.20.50.8-0.80.7-0.5-0.9-0.60.70.60.60.6-0.70.60.6
Pavlov. Cond. index score0.00.00.0-0.0-0.2-0.20.1-0.10.10.00.00.0-0.00.0-0.2
Pavlov. Cond. latency score0.00.00.1-0.2-0.0-0.3-0.1-0.20.20.20.20.2-0.20.10.0
Pavlov. Cond. lever contacts0.30.40.40.6-0.70.60.60.6-0.6-0.6-0.6-0.60.6-0.6-0.6
Pavlov. Cond. magazine entry number0.20.30.50.5-0.30.70.40.6-0.6-0.6-0.6-0.50.5-0.5-0.4
Pavlov. Cond. intertrial magazine entries0.00.00.10.00.00.3-0.00.1-0.1-0.1-0.1-0.10.1-0.1-0.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.2-0.4-0.10.30.1-0.0-0.1-0.1-0.10.1-0.1-0.3
Pavlov. Cond. response bias0.00.00.10.1-0.20.10.20.2-0.1-0.2-0.2-0.20.2-0.2-0.3
Time in closed arm before self-admin0.50.81.31.2-1.01.11.00.9-0.8-0.9-0.8-0.80.8-0.8-0.4
Time in closed arm after self-admin1.41.62.5-1.31.4-1.6-1.1-1.41.31.31.31.3-1.31.30.6
Time in open arm before self-admin0.40.51.0-0.81.0-0.9-0.7-0.70.60.60.60.6-0.60.60.1
Time in open arm after self-admin0.00.00.00.1-0.20.10.20.1-0.1-0.1-0.1-0.10.1-0.1-0.1
Bone: periosteal estimation0.30.81.30.9-0.81.10.71.0-0.9-1.0-0.9-0.90.9-0.9-0.5
Bone: periosteal perimeter0.61.12.01.2-1.01.40.91.2-1.0-1.1-1.1-1.11.0-1.1-0.5
Bone: post-yield work0.20.40.5-0.70.6-0.7-0.6-0.70.60.70.70.6-0.60.60.5
Progressive ratio test 1 active lever presses2.64.57.32.4-2.02.71.72.4-2.4-2.2-2.1-2.12.0-2.0-1.0
Progressive ratio test 1 breakpoint2.44.16.72.2-1.92.61.62.3-2.3-2.1-2.0-2.01.9-1.9-0.9
Progressive ratio test 1 inactive lever presses1.43.74.62.2-1.92.01.92.0-2.1-1.9-1.9-1.91.9-1.8-1.5
Progressive ratio test 2 active lever presses3.55.06.82.6-2.32.52.22.3-2.3-2.2-2.2-2.22.1-2.2-1.4
Progressive ratio test 2 breakpoint4.25.37.22.7-2.42.52.32.4-2.3-2.3-2.3-2.32.2-2.2-1.5
Progressive ratio test 2 inactive lever presses0.92.73.61.9-1.61.91.61.7-1.7-1.7-1.6-1.61.6-1.6-1.0
Incentive Sensitization - Responses1.23.34.72.2-1.92.02.01.9-1.7-1.8-1.8-1.71.7-1.7-1.1
Incentive Sensitization - Breakpoint1.43.14.62.1-1.91.92.01.8-1.7-1.8-1.7-1.71.7-1.7-1.1
Sum of active levers in priming session hrs 5-61.00.91.5-1.10.8-1.2-0.9-1.01.01.00.90.9-0.90.90.4
Progressive ratio0.61.93.4-1.51.2-1.8-1.4-1.51.41.41.31.3-1.21.30.8
Food seeking constrained by brief footshock3.34.16.1-2.31.8-1.6-2.5-1.92.11.92.02.0-2.02.02.1
Seeking ratio, punishment vs. effort0.10.20.6-0.40.30.2-0.5-0.20.30.30.30.3-0.40.40.8
Retroperitoneal fat weight0.00.10.50.20.10.7-0.20.4-0.4-0.2-0.2-0.20.1-0.10.5
Reaction time number correct1.24.36.52.2-2.62.02.22.0-2.0-2.0-2.0-2.02.0-2.0-1.7
Reaction time mean minus median0.21.62.1-1.51.4-1.2-1.4-1.21.21.21.21.2-1.21.21.1
Reaction time mean minus median AUC0.00.20.3-0.60.6-0.4-0.6-0.50.40.50.50.5-0.50.50.5
Reaction time num false alarms4.67.89.53.1-2.72.53.02.7-2.8-2.7-2.8-2.82.8-2.8-2.7
Reaction time num false alarms AUC3.17.08.52.9-2.52.52.82.6-2.7-2.6-2.7-2.72.6-2.6-2.5
Reaction time trials correct on left1.24.36.52.2-2.62.02.22.0-2.0-2.0-2.0-2.02.0-2.0-1.7
Reaction time trials on left1.34.46.72.3-2.62.02.22.1-2.0-2.0-2.0-2.02.0-2.0-1.8
Reaction time mean1.43.03.8-2.01.9-1.7-1.9-1.71.61.71.71.7-1.71.71.5
Reaction time mean AUC0.92.33.0-1.71.6-1.5-1.6-1.51.41.51.51.5-1.51.51.2
Median of all reaction times1.52.43.0-1.71.6-1.6-1.6-1.61.51.51.51.5-1.51.51.2
Reaction time omissions0.10.10.30.3-0.50.00.50.2-0.3-0.2-0.2-0.20.3-0.2-0.6
Reaction time false alarm rate0.70.91.21.1-0.60.91.01.0-1.0-1.0-1.0-1.01.0-1.0-1.0
Reaction time premature initiation rate0.40.62.2-0.70.80.0-1.1-0.40.50.60.70.7-0.70.71.5
Reaction time premature initiations0.10.20.70.3-0.40.8-0.10.5-0.4-0.3-0.2-0.20.2-0.20.6
Std. dev. reaction times0.51.62.0-1.41.4-1.2-1.4-1.21.11.21.21.2-1.21.21.1
Reaction time trials completed1.34.46.72.3-2.62.02.22.1-2.0-2.0-2.0-2.02.0-2.0-1.8
Reaction time trials AUC1.65.78.32.6-2.92.32.52.4-2.3-2.3-2.3-2.32.3-2.3-2.0
Run reversals in cocaine runway, females0.50.61.0-0.30.3-0.8-0.3-0.80.70.90.90.9-0.90.91.0
Run reversals in cocaine runway, males0.30.30.40.5-0.40.60.50.6-0.5-0.6-0.6-0.60.6-0.6-0.6
Latency to leave start box in cocaine runway0.20.31.1-0.30.6-0.0-0.7-0.30.20.40.40.4-0.50.41.1
Latency to leave start box in cocaine runway, F0.10.10.60.2-0.00.8-0.20.4-0.4-0.2-0.2-0.20.1-0.10.7
Latency to leave start box in cocaine runway, M0.20.20.3-0.30.4-0.6-0.2-0.50.40.40.40.4-0.40.40.3
Std. dev. time between licks in bursts0.10.31.00.4-0.40.10.60.4-0.5-0.4-0.5-0.50.5-0.5-1.0
Total sessions with >9 infusions3.44.25.72.3-2.12.41.82.2-2.2-2.1-2.1-2.02.0-2.0-1.3
Short access day 1 total inactive lever presses1.93.74.82.2-2.12.11.92.0-1.9-1.9-1.9-1.91.9-1.9-1.1
Short access day 10 total inactive lever presses0.21.11.4-1.00.9-1.1-0.9-1.11.21.01.11.1-1.11.10.9
Short access day 1 total infusions1.52.93.82.0-1.71.91.61.8-1.8-1.7-1.7-1.71.6-1.6-1.0
Short access day 10 total infusions3.55.76.72.6-2.52.32.42.4-2.4-2.4-2.4-2.42.4-2.4-2.1
Short access total infusions2.63.74.62.2-1.92.01.92.0-2.1-1.9-1.9-1.91.9-1.9-1.5
Short access day 1 locomotion3.15.16.22.5-2.32.52.12.4-2.4-2.3-2.3-2.32.2-2.2-1.7
Short access day 10 total locomotion0.00.10.60.00.10.2-0.2-0.10.30.10.20.2-0.30.20.8
Short access total locomotion0.71.12.11.3-1.11.51.01.2-1.0-1.1-1.0-1.00.9-1.0-0.3
One hour access (0.3 mA shock)0.10.20.40.6-0.30.60.40.5-0.5-0.4-0.4-0.40.4-0.40.0
Compulsive drug intake0.00.10.20.3-0.40.10.40.2-0.2-0.2-0.2-0.20.2-0.3-0.3
One hour access (shock baseline)0.61.52.11.5-1.11.41.01.3-1.3-1.2-1.2-1.21.2-1.2-0.7
Social response proportion0.50.72.20.7-0.80.31.00.6-0.6-0.7-0.8-0.80.8-0.8-1.5
Social responses0.91.23.20.9-1.30.41.30.8-0.9-1.0-1.0-1.01.1-1.1-1.8
Social time2.23.56.1-2.22.0-2.5-1.7-2.11.91.91.81.8-1.71.70.6
Soleus weight0.31.02.41.3-1.60.51.50.7-0.7-0.8-0.8-0.80.9-0.8-1.0
Bone: stiffness0.81.41.61.3-1.11.11.21.2-1.2-1.2-1.2-1.21.2-1.2-1.2
Tibialis anterior weight4.314.817.84.2-4.03.84.13.9-3.9-3.8-3.8-3.83.8-3.8-3.4
Time to tail flick, vehicle, before self-admin1.31.63.61.1-1.01.90.71.5-1.5-1.3-1.3-1.21.2-1.2-0.2
Time to tail flick, vehicle, after self-admin0.20.40.9-0.70.9-0.6-0.7-0.60.70.60.60.6-0.60.60.3
Time to tail flick, test, before self-admin0.80.91.8-1.01.3-0.3-1.3-0.70.70.90.90.9-0.90.91.3
Time to tail flick, test, after self-admin0.00.00.10.3-0.10.20.30.1-0.10.00.00.0-0.10.00.2
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.60.7-0.6-0.5-0.60.70.60.60.5-0.50.50.2
Delta time to tail flick, test, before/after SA1.21.52.61.5-1.61.21.61.1-1.0-1.1-1.1-1.11.1-1.1-0.9
Tibia length0.51.42.81.4-1.40.61.70.9-0.9-1.1-1.1-1.11.2-1.2-1.5
Ambulatory time before self-admin0.00.10.1-0.40.3-0.3-0.3-0.30.40.20.20.2-0.20.20.1
Ambulatory time after self-admin0.91.52.2-1.41.2-1.5-1.1-1.31.31.21.21.2-1.21.20.7
Bone: tissue strength0.40.40.5-0.60.5-0.7-0.6-0.70.70.60.60.6-0.60.60.5
Total heroin consumption0.00.10.30.1-0.3-0.10.30.1-0.1-0.2-0.2-0.20.2-0.2-0.5
Bone: trabecular number0.00.00.20.10.30.4-0.20.1-0.1-0.00.00.0-0.10.10.5
Bone: trabecular spacing0.00.00.1-0.1-0.2-0.20.0-0.10.0-0.0-0.0-0.00.1-0.0-0.3
Bone: trabecular thickness1.11.53.01.3-0.71.70.91.4-1.2-1.3-1.2-1.21.2-1.2-0.5
Bone: trabecular tissue density0.10.20.40.4-0.60.20.60.3-0.2-0.3-0.3-0.40.4-0.4-0.5
Water consumed over 24 hours0.40.81.1-0.91.0-0.6-1.0-0.80.90.80.90.9-0.90.91.0
Number of responses in last shaping day1.72.23.11.8-1.81.31.81.4-1.3-1.4-1.4-1.41.4-1.4-1.2