Hub : Genes

Arfgap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	mRNA stability	Arfgap3	0.03	0.02	4.4e-04	0.03	0.03	0.03	0.02	4.9e-04	6.9e-04	5.2e-04	1.1e-03
2	Adipose	gene expression	Arfgap3	0.21	0.16	7.1e-09	0.06	0.06	0.06	0.05	4.9e-07	7.4e-07	3.9e-07	1.7e-06
3	Liver	gene expression	Arfgap3	0.16	0.1	5.1e-03	0.03	0.01	0.01	0.02	5.1e-04	5.1e-02	8.5e-03	3.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.2	0.3	0.5	0.6	-0.7	0.1
Area under the delay curve	0.7	0.8	1.9	1.4	-0.6	-0.3
BMI with tail	0.9	2.9	6.5	-2.5	0.6	1.4
BMI without tail	0.3	0.6	1.7	-1.3	0.4	-0.1
Body weight	0.9	3.6	8.4	-2.9	1.3	0.8
Weight adjusted by age	0.8	1.0	2.0	-0.3	1.4	-0.9
Bone surface	0.0	0.0	0.0	-0.0	0.1	0.0
Bone volume	0.0	0.0	0.0	0.1	0.2	-0.0
Breakpoint value in progressive ratio session	0.4	0.5	0.8	-0.4	-0.9	0.7
Number of licking bursts	0.1	0.1	0.2	0.4	-0.2	-0.3
Context. condit. distance diff. score	3.8	4.6	7.7	-2.5	2.8	0.0
Locomotion velocity, session 1	0.4	0.4	0.7	-0.8	0.6	-0.3
Locomotion distance, session 1	0.6	0.8	1.6	0.7	-0.5	-1.3
Locomotion velocity, session 2	0.4	0.5	1.3	-1.1	0.4	-0.0
Locomotion distance, session 2	1.7	2.4	5.3	1.2	-2.3	0.5
Locomotion velocity, session 3	0.8	0.9	1.2	-0.9	1.1	-0.8
Locomotion distance, session 3	1.2	1.3	2.9	0.9	0.4	-1.7
Stereotopy head waving bouts, day 3	0.5	0.6	1.0	-1.0	0.2	0.8
Stereotopy head waving duration, day 3	2.4	2.9	6.2	-2.5	1.3	0.8
Locomotion velocity, session 7	0.2	0.3	0.7	-0.2	0.3	-0.8
Locomotion distance, session 7	0.6	0.7	1.2	1.0	-1.1	-0.1
Stereotopy head waving bouts, day 7	3.0	3.4	5.7	-2.4	2.1	-0.3
Stereotopy head waving duration, day 7	2.3	2.8	4.2	-2.0	2.0	-0.7
Locomotion velocity, session 8	3.0	3.6	8.3	-2.9	1.2	1.0
Locomotion distance, session 8	0.6	0.9	1.4	-1.1	1.2	-0.1
Degree of sensitization distance	1.3	1.3	2.8	-0.9	-0.5	1.7
Degree of sensitization stereotypy	2.6	2.9	4.2	-2.1	1.9	-0.8
Conditioned locomotion	0.9	1.1	2.0	-0.2	1.4	-1.1
Cocaine response after cond. corrected	0.2	0.2	0.5	0.1	0.7	-0.4
Cocaine response after cond. not corrected	0.3	0.3	0.6	0.1	0.8	-0.5
Cocaine response before conditioning	0.0	0.1	0.1	0.3	-0.2	-0.2
Saline control response	0.7	0.9	1.9	-0.4	1.4	-0.8
Bone: connectivity density	0.2	0.3	0.6	0.2	-0.8	0.4
Bone: cortical apparent density	0.7	1.0	1.9	1.4	-1.0	-0.0
Bone: cortical area	0.8	1.2	2.1	-1.5	0.9	0.8
Bone: cortical porosity	0.3	0.4	0.8	-0.9	0.5	-0.0
Bone: cortical porosity	0.7	0.8	1.4	-1.2	0.9	0.3
Bone: cortical thickness	0.7	1.1	2.2	-0.3	-1.1	1.5
Bone: cortical thickness	0.5	0.6	1.4	-0.4	-0.4	1.2
Bone: cortical tissue density	0.7	0.9	1.8	1.3	-1.0	0.0
Condit. Reinf. active minus inactive responses	1.2	1.4	1.8	1.3	-1.3	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.0	-0.1	0.5
Condit. Reinf. active responses	2.1	2.5	5.0	2.2	-1.6	0.3
Condit. Reinf. inactive responses	1.8	2.1	4.4	2.1	-1.4	-0.4
Incentive salience index mean	1.9	2.3	3.2	1.8	-1.8	0.7
Condit. Reinf. lever presses	1.5	2.1	3.6	1.9	-1.6	0.1
Condit. Reinf. active minus inactive responses	1.3	1.6	2.7	-0.3	-1.4	1.6
Condit. Reinf. active-inactive response ratio	2.3	2.4	4.4	-0.2	-1.7	2.1
Condit. Reinf. active responses	0.6	0.8	1.4	-0.9	-0.2	1.2
Condit. Reinf. inactive responses	0.6	0.7	1.2	-0.9	1.1	-0.2
Condit. Reinf. lever presses	0.8	1.1	1.7	0.6	-1.3	1.1
Condit. Reinf. lever reinforcers received	0.5	0.8	1.8	-0.3	-0.6	1.3
Conditioned reinforcement - actives	0.4	0.4	0.9	0.5	1.0	-0.1
Conditioned reinforcement - inactives	0.5	0.6	0.9	0.1	-0.9	0.9
Conditioned locomotion	0.7	0.8	0.9	-0.8	0.9	1.0
Patch foraging indifference point 0 sec	0.6	1.0	1.7	0.3	-1.3	1.1
Patch foraging indifference point AUC	0.1	0.1	0.2	0.4	-0.3	0.2
Delay disc. indifference point, 0s delay	0.3	0.3	0.6	-0.7	0.5	0.3
Delay disc. indifference point, 16s delay	1.8	1.9	4.0	2.0	-1.2	-0.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	0.6	-0.1	-0.3
Delay disc. indifference point, 24s delay	0.3	0.3	0.5	0.7	0.2	-0.6
Delay disc. indifference point, 4s delay	0.7	0.7	1.5	0.4	-0.7	1.2
Delay disc. indifference point, 8s delay	1.4	1.4	3.0	1.7	-0.9	-0.7
Indifference point function ln k	0.7	1.0	2.6	-1.6	0.5	0.4
Indifference point function log k	0.7	1.0	2.6	-1.6	0.5	0.4
Patch foraging total patch changes 0 sec	0.6	1.0	1.9	0.3	-1.4	1.0
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-0.0	-0.7	1.0
Patch foraging total patch changes 18 sec	1.0	1.2	2.0	0.0	-1.4	1.3
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.4	-0.3	0.2
Patch foraging total patch changes 6 sec	0.6	0.8	1.8	-0.1	-0.9	1.3
Patch foraging time to switch 0 sec	0.3	0.5	0.7	0.9	-0.2	-0.8
Patch foraging water rate 0 sec	0.6	0.9	1.6	-1.1	-0.2	1.3
Patch foraging water rate 12 sec	0.2	0.3	0.9	-0.9	-0.2	0.2
Patch foraging water rate 18 sec	0.1	0.2	0.4	0.3	-0.6	0.3
Patch foraging water rate 24 sec	1.3	1.8	2.9	-1.7	-0.5	1.5
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.3	-0.1	-0.4
Seeking ratio, delayed vs. immediate footshock	2.5	2.8	6.4	1.5	-2.5	-0.0
Distance traveled before self-admin	0.8	0.9	1.9	0.4	-1.4	0.8
Distance traveled after self-admin	0.9	1.0	2.1	-0.4	-0.8	1.4
Extensor digitorum longus weight	0.0	0.1	0.1	-0.3	0.1	-0.3
Bone: elastic displacement	1.1	1.2	1.8	-1.3	1.4	-0.5
Bone: elastic work	2.1	2.7	5.4	-2.3	1.3	1.0
Bone: endosteal estimation	1.8	3.8	7.4	-1.9	2.7	-0.6
Bone: endosteal perimeter	2.3	4.8	9.8	-1.8	3.1	-1.1
Epididymis fat weight	1.4	3.2	5.9	-1.8	2.4	-0.6
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.0	0.6	0.5
Delta time in open arm before/after self-admin	0.4	0.4	0.8	-0.2	0.6	-0.9
Diff in mean of infusions in LGA sessions	0.6	0.6	1.3	1.1	-0.7	-0.1
Delay discount exponential model param	0.7	0.7	1.7	-1.3	0.5	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.6	0.7	0.2	0.2
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.7	0.1	0.4
Bone: final force	1.0	1.7	4.0	-1.0	-0.1	2.0
Bone: final moment	1.3	2.1	4.6	-1.3	0.0	2.2
Food consumed during 24 hour testing period	1.1	1.3	2.6	-1.6	0.2	1.1
Glucose	0.4	0.7	1.6	0.6	-1.3	0.2
Heart weight	1.6	2.2	3.2	-1.8	0.6	1.8
Delay discount hyperbolic model param	0.5	0.5	1.3	-1.1	0.4	0.2
Intermittent access intake day 1-15 change	0.4	0.4	0.8	0.9	-0.5	0.0
Intermittent access intake escalation	0.3	0.3	0.6	0.8	-0.6	0.1
Intermittent access intake escalation 2	0.1	0.1	0.2	0.4	-0.1	-0.1
Intermitt. access day 1 inactive lever presses	1.2	1.2	2.6	-0.9	-0.5	1.6
Intermitt. access day 15 inactive lever presses	1.8	2.0	4.8	-0.5	-1.0	2.2
Intermitt. access escalation Index	0.4	0.4	0.4	0.5	-0.7	0.6
Intermittent access day 1 total infusions	0.6	0.7	1.0	-1.0	0.3	1.0
Intermittent access day 15 total infusions	0.3	0.3	0.8	-0.2	-0.4	0.9
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	0.3	0.1
Intermittent access total infusions	0.2	0.2	0.4	-0.4	0.2	0.6
Intermittent access day 1 locomotion	0.2	0.2	0.5	-0.3	-0.0	0.7
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.3	0.2	0.5
Intermittent access total locomotion	0.3	0.4	0.9	-0.5	-0.2	0.9
Intermittent access standard deviation	0.5	0.5	1.1	-0.6	-0.1	1.1
Left kidney weight	7.1	20.0	37.5	-6.1	3.7	3.0
Right kidney weight	7.8	21.8	41.1	-6.4	3.7	3.2
Cocaine induced anxiety	1.3	1.5	2.2	-1.4	-0.5	1.5
Post-drug Anxiety	1.1	1.2	2.3	-1.5	-0.5	1.0
Baseline Anxiety	0.8	0.9	2.0	0.8	-0.3	-1.4
Tail length	0.1	0.3	0.9	-0.0	0.2	-0.9
Length with tail	0.2	0.6	1.3	-1.1	0.7	0.0
Length without tail	0.4	0.8	1.4	-1.1	0.0	1.2
Times rat made contact with spout	0.9	1.0	2.3	-1.5	0.2	0.8
Lifetime Intake	0.6	0.7	1.7	-0.6	-0.1	1.3
Liver weight, left	0.9	1.4	3.2	-0.4	1.8	-0.9
Liver weight, right	1.9	3.1	7.1	-0.6	2.7	-1.4
Locomotor activity	1.5	2.4	3.9	-2.0	1.7	0.5
Locomotor testing distance	0.0	0.0	0.1	0.2	0.2	-0.1
Locomotor testing rearing	0.9	1.4	3.8	-0.6	2.0	-0.2
Locomotion in novel chamber	2.0	2.5	4.9	0.2	1.6	-2.2
Locomotion in novel chamber post-restriction	0.8	1.0	1.7	1.1	-0.3	-1.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.5	0.7	0.2	-0.2
Change in fecal boli incidents, locomotor task	0.6	0.6	0.8	-0.9	0.9	-0.4
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.0	0.2	0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.4	-0.2	-0.1
Total resting periods, locomotor time 1	0.3	0.4	0.6	0.7	-0.8	0.1
Rest time, locomotor task time 1	0.3	0.4	0.8	0.2	-0.9	0.5
Distance moved, locomotor task time 1	0.6	0.6	1.8	-0.3	1.3	-0.2
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	0.2	0.1
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.5	0.5	0.2	-0.7
Bouts of movement, locomotor time 2	0.4	0.4	0.6	0.4	-0.8	0.7
Total resting periods, locomotor time 2	0.5	0.6	1.0	0.3	-1.0	0.8
Rest time, locomotor task time 2	0.3	0.3	0.8	0.3	-0.9	0.2
Distance moved, locomotor task time 2	0.8	0.9	1.8	-0.8	1.4	-0.5
Vertical activity count, locomotor time 2	0.6	0.6	1.1	-0.8	1.1	-0.3
Light reinforcement 1	0.4	0.7	1.3	-0.6	1.2	-0.6
Light reinforcement 2	0.2	0.3	0.7	-0.8	0.4	-0.4
Bone: marrow area	1.8	4.0	7.6	-2.0	2.8	-0.5
Bone: maximum diameter	3.0	5.5	10.0	-3.2	2.3	1.0
Bone: maximum force	1.7	2.9	4.3	-2.0	0.6	2.1
Bone: maximum moment	2.1	3.6	5.4	-2.3	0.8	2.2
Mean time between licks in bursts	0.5	0.7	1.7	1.3	-0.1	-0.6
Mean num. licks in bursts	1.0	1.2	2.7	-1.6	0.8	0.6
Cd content in liver	2.1	2.3	4.4	-1.4	2.1	-0.6
Co content in liver	0.5	0.5	0.8	-0.9	0.7	0.5
Cu content in liver	2.9	3.6	7.7	2.8	-1.7	-0.5
Fe content in liver	0.2	0.3	0.5	-0.7	0.6	0.1
K content in liver	1.0	1.0	1.5	0.6	-1.2	1.1
Mg content in liver	2.5	2.5	5.0	0.8	-2.2	1.4
Mn content in liver	0.4	0.4	0.7	-0.1	0.9	-0.8
Na content in liver	1.2	1.3	2.1	1.2	-1.5	-0.4
Rb content in liver	0.3	0.4	0.7	-0.1	-0.6	0.9
Se content in liver	0.6	0.8	1.6	1.3	0.2	-0.8
Sr content in liver	0.7	0.6	1.0	0.9	-0.1	-1.0
Zn content in liver	0.4	0.5	0.9	1.0	-0.3	-0.7
Bone: minimum diameter	0.5	0.9	2.1	-0.8	1.5	-0.3
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.3	0.7	-0.6
Time in novel zone, hab. session 1	0.8	0.8	1.2	-1.0	1.1	0.2
Total zone transitions, hab. session 1	1.3	1.9	2.8	1.7	-0.8	-1.5
Total locomotion distance, hab. session 1	1.0	1.4	3.5	0.8	0.2	-1.9
Locomotion velocity, hab. session 1	0.8	1.1	2.3	0.9	-0.4	-1.5
Time in familiar zone, hab. session 2	2.0	2.1	4.1	0.4	1.4	-2.0
Time in novel zone, hab. session 2	1.8	1.7	3.5	-1.1	-0.8	1.9
Total zone transitions, hab. session 2	0.2	0.2	0.6	0.2	-0.7	0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.4	-0.7	-0.1
Locomotion velocity, hab. session 2	0.4	0.5	1.0	0.7	-1.0	-0.2
Novel to familiar place preference ratio	2.5	2.6	4.2	-1.8	2.1	0.4
Novelty place preference	3.3	3.4	5.8	-2.1	2.4	0.3
Time in novel zone, NPP test	4.2	4.3	6.9	-2.4	2.6	0.4
Total zone transitions, NPP test	0.6	0.9	1.2	1.1	-0.6	-1.1
Total locomotion distance, NPP test	0.3	0.4	0.6	0.7	-0.7	-0.4
Locomotion velocity, NPP test	0.9	1.3	2.0	1.4	-0.9	-1.0
Intraocular pressure	0.2	0.3	0.6	-0.8	0.5	-0.2
Delta distance traveled before/after self-admin	1.3	1.4	2.5	-1.6	1.3	0.4
Delta ambulatory time before/after self-admin	1.8	2.0	3.9	-2.0	1.3	0.7
Parametrial fat weight	0.0	0.1	0.1	0.1	-0.3	0.4
Pavlov. Cond. lever latency	1.7	2.2	4.3	-2.1	1.5	-0.1
Pavlov. Cond. magazine entry latency	1.4	1.8	2.7	1.6	-1.6	0.2
Pavlov. Cond. change in total contacts	2.2	2.4	4.1	1.6	-2.0	0.8
Pavlov. Cond. index score	1.4	1.8	2.8	1.5	-1.7	0.7
Pavlov. Cond. latency score	1.2	1.5	2.2	1.4	-1.5	0.7
Pavlov. Cond. lever contacts	2.1	2.4	4.1	2.0	-1.8	0.1
Pavlov. Cond. magazine entry number	1.2	1.5	2.2	-1.5	1.5	-0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	0.8	-1.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	3.1	1.6	-1.8	0.4
Pavlov. Cond. response bias	2.1	2.6	3.9	2.0	-2.0	0.3
Pavlov. Cond. lever latency	1.0	1.4	2.4	-0.6	1.6	-1.1
Pavlov. Cond. magazine entry latency	4.6	5.3	8.8	2.0	-3.0	1.7
Pavlov. Cond. change in total contacts	3.7	5.1	8.4	0.6	-2.5	2.9
Pavlov. Cond. index score	3.2	4.1	7.1	1.5	-2.7	1.7
Pavlov. Cond. latency score	3.9	4.9	8.6	1.6	-2.9	1.9
Pavlov. Cond. lever contacts	1.5	2.0	3.7	0.6	-1.9	1.4
Pavlov. Cond. magazine entry number	3.5	4.3	6.6	-1.7	2.6	-1.9
Pavlov. Cond. intertrial magazine entries	1.3	1.7	3.7	-1.9	0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.1	7.0	1.6	-2.6	1.6
Pavlov. Cond. response bias	2.1	2.9	4.9	0.9	-2.2	1.7
Time in closed arm before self-admin	2.4	2.7	4.8	1.7	-2.2	-0.5
Time in closed arm after self-admin	0.1	0.1	0.2	0.2	0.4	-0.2
Time in open arm before self-admin	0.5	0.5	0.7	0.2	0.8	-0.9
Time in open arm after self-admin	0.7	0.8	1.6	0.1	0.9	-1.3
Bone: periosteal estimation	1.6	3.3	5.5	-2.1	2.4	0.1
Bone: periosteal perimeter	2.5	4.2	7.6	-2.2	2.8	-0.3
Bone: post-yield work	0.5	0.6	1.2	-0.9	-0.1	1.1
Progressive ratio test 1 active lever presses	0.6	0.6	1.2	-0.2	-0.7	1.1
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	0.0	-0.6	0.6
Progressive ratio test 1 inactive lever presses	1.4	1.5	3.1	-0.1	-1.2	1.8
Progressive ratio test 2 active lever presses	0.8	0.9	1.4	-0.3	-1.1	1.2
Progressive ratio test 2 breakpoint	1.1	1.2	2.2	-0.4	-1.1	1.5
Progressive ratio test 2 inactive lever presses	1.8	2.1	3.4	0.1	-1.9	1.7
Incentive Sensitization - Responses	1.0	1.0	1.2	-0.7	-1.1	1.1
Incentive Sensitization - Breakpoint	1.1	1.1	1.6	-0.8	-1.1	1.3
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.3	0.2	-0.0
Progressive ratio	0.3	0.3	0.5	0.2	-0.7	0.7
Food seeking constrained by brief footshock	0.4	0.5	0.8	-0.9	0.6	0.5
Seeking ratio, punishment vs. effort	0.2	0.2	0.3	-0.5	0.6	0.0
Retroperitoneal fat weight	0.8	2.7	4.2	-1.9	2.0	0.6
Reaction time number correct	1.2	1.7	2.9	1.5	0.4	-1.7
Reaction time mean minus median	0.5	0.7	1.1	-0.8	1.0	-0.6
Reaction time mean minus median AUC	0.8	1.0	1.6	-1.1	1.3	-0.6
Reaction time num false alarms	1.0	1.4	2.5	-0.0	1.6	-1.3
Reaction time num false alarms AUC	0.9	1.3	2.4	-0.0	1.6	-1.2
Reaction time trials correct on left	1.2	1.7	2.9	1.5	0.4	-1.7
Reaction time trials on left	1.3	1.9	3.1	1.5	0.4	-1.8
Reaction time mean	0.0	0.0	0.0	0.1	-0.2	-0.1
Reaction time mean AUC	0.0	0.0	0.0	0.1	-0.2	-0.2
Median of all reaction times	0.1	0.2	0.4	0.4	-0.6	0.1
Reaction time omissions	0.4	0.5	0.8	0.6	0.5	-0.9
Reaction time false alarm rate	0.4	0.6	1.1	-0.7	1.1	-0.2
Reaction time premature initiation rate	1.3	1.7	3.2	-0.0	-1.4	1.8
Reaction time premature initiations	0.5	0.8	1.1	0.6	-1.1	0.9
Std. dev. reaction times	0.3	0.5	1.1	-0.5	1.0	-0.3
Reaction time trials completed	1.3	1.9	3.1	1.5	0.4	-1.8
Reaction time trials AUC	1.0	1.4	2.3	1.3	0.3	-1.5
Run reversals in cocaine runway, females	1.3	1.3	2.9	1.0	0.3	-1.7
Run reversals in cocaine runway, males	1.3	1.2	2.1	-1.2	1.4	-0.3
Latency to leave start box in cocaine runway	0.2	0.2	0.4	-0.6	0.6	0.0
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.3	0.1	-0.4
Latency to leave start box in cocaine runway, M	0.8	0.8	1.3	-1.1	0.5	1.0
Std. dev. time between licks in bursts	1.2	1.4	2.3	1.1	-1.5	0.9
Total sessions with >9 infusions	0.7	0.8	1.8	-0.7	0.2	1.3
Short access day 1 total inactive lever presses	1.5	1.7	2.7	-1.5	0.5	1.7
Short access day 10 total inactive lever presses	1.1	1.2	2.9	-1.7	0.8	0.4
Short access day 1 total infusions	1.0	1.1	2.0	-1.1	0.2	1.4
Short access day 10 total infusions	0.2	0.2	0.6	0.1	-0.1	0.8
Short access total infusions	1.2	1.3	3.1	-1.0	-0.1	1.8
Short access day 1 locomotion	0.2	0.2	0.4	0.3	-0.1	0.7
Short access day 10 total locomotion	0.5	0.5	1.5	1.2	-0.3	-0.0
Short access total locomotion	0.3	0.3	0.7	0.3	0.0	0.8
One hour access (0.3 mA shock)	0.1	0.1	0.3	0.5	-0.2	-0.2
Compulsive drug intake	0.3	0.3	0.7	0.8	-0.4	-0.3
One hour access (shock baseline)	0.0	0.1	0.1	0.3	-0.1	-0.2
Social response proportion	0.5	0.6	1.1	-0.5	-0.5	1.1
Social responses	0.2	0.2	0.3	0.5	0.5	-0.3
Social time	1.6	2.1	4.0	2.0	-1.5	-0.5
Soleus weight	0.1	0.3	0.4	-0.6	-0.5	0.6
Bone: stiffness	0.7	1.2	2.3	-1.1	0.3	1.5
Tibialis anterior weight	0.2	0.8	1.5	0.9	-1.2	0.3
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.9	-0.4	0.9	-0.1
Time to tail flick, vehicle, after self-admin	2.2	2.3	3.5	0.8	1.7	-1.9
Time to tail flick, test, before self-admin	1.1	1.1	1.8	-0.3	1.3	-1.2
Time to tail flick, test, after self-admin	1.5	1.6	3.8	1.9	-0.1	-1.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	0.2	0.0	0.0
Delta time to tail flick, test, before/after SA	1.8	1.6	3.7	1.9	-1.0	-0.1
Tibia length	0.5	1.4	2.6	-1.6	0.5	1.2
Ambulatory time before self-admin	0.5	0.5	1.1	0.2	-1.1	0.6
Ambulatory time after self-admin	0.4	0.5	0.8	-0.4	-0.7	0.9
Bone: tissue strength	0.3	0.2	0.5	-0.5	0.1	0.7
Total heroin consumption	0.3	0.3	0.5	-0.7	-0.1	0.6
Bone: trabecular number	0.2	0.3	0.7	0.3	0.4	-0.8
Bone: trabecular spacing	0.4	0.6	0.9	-0.9	-0.0	0.9
Bone: trabecular thickness	0.1	0.1	0.3	0.6	-0.3	-0.1
Bone: trabecular tissue density	0.7	0.9	1.3	1.0	-1.1	0.8
Water consumed over 24 hours	1.9	2.3	6.1	-2.5	0.5	0.7
Number of responses in last shaping day	2.0	2.1	4.8	0.8	-2.2	0.9