Hub : Genes

Arfgap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb isoform ratio NM_001044273.1 0.16 0.11 2.6e-03 0.1 0.08 0.08 0.08 2.2e-03 5.8e-03 5.7e-03 4.9e-03
2 Adipose gene expression Arfgap3 0.17 0.14 2.6e-09 0.06 0.06 0.05 0.06 5.9e-07 5.9e-07 1.6e-06 6.6e-07
3 Brain mRNA stability Arfgap3 0.02 0.02 5.2e-03 0.02 0.02 0.02 0.02 2.2e-03 4.6e-03 7.2e-03 3.2e-03
4 Adipose alternative TSS NM_001044273.1 0.03 0.03 2.1e-03 0.01 0.01 0.01 0.01 1.2e-02 1.2e-02 6.9e-02 1.7e-02
5 NAcc gene expression Arfgap3 0.01 0.01 8.6e-03 0 0.01 -0 0 9.0e-02 4.0e-02 4.9e-01 2.4e-01
6 PL mRNA stability Arfgap3 0.02 0.02 2.2e-03 0.03 0.02 0.02 0.02 7.4e-04 1.5e-03 1.6e-03 1.8e-03
7 Adipose isoform ratio NM_001044273.1 0.03 0.02 8.2e-04 0.01 0.01 0.01 0.01 9.1e-03 1.2e-02 7.9e-03 2.3e-02
8 Liver gene expression Arfgap3 0.17 0.11 2.2e-03 0.03 0.01 -0 0.02 3.8e-04 6.7e-02 3.7e-01 5.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.40.71.2-0.81.0-0.7-1.00.8-1.1-0.7-0.3
Area under the delay curve1.01.22.5-0.71.1-0.8-1.21.3-1.4-1.60.3
BMI with tail1.13.67.61.7-1.91.52.0-2.11.82.8-0.9
BMI without tail0.41.13.00.7-1.00.31.3-1.01.31.70.1
Body weight1.46.27.62.4-2.72.52.7-2.62.72.6-1.2
Weight adjusted by age0.20.21.00.3-0.50.30.4-0.30.40.31.0
Bone surface0.10.10.5-0.10.30.4-0.30.2-0.1-0.70.0
Bone volume0.10.10.3-0.20.30.1-0.30.2-0.3-0.6-0.1
Breakpoint value in progressive ratio session0.20.30.60.3-0.50.50.5-0.40.60.3-0.8
Number of licking bursts0.10.20.5-0.70.2-0.60.00.4-0.0-0.40.2
Context. condit. distance diff. score4.95.99.33.0-2.62.62.4-2.61.92.8-0.3
Locomotion velocity, session 10.60.71.60.6-0.71.10.9-0.81.30.10.3
Locomotion distance, session 11.11.43.5-1.91.2-1.3-1.00.8-0.5-0.81.3
Locomotion velocity, session 20.60.71.60.4-0.71.00.8-1.01.30.80.0
Locomotion distance, session 21.62.24.5-2.11.7-1.7-1.61.3-0.8-1.4-0.5
Locomotion velocity, session 30.30.30.60.4-0.40.60.4-0.60.50.60.8
Locomotion distance, session 31.81.93.0-1.41.2-1.5-1.31.2-1.7-0.81.7
Stereotopy head waving bouts, day 31.01.12.21.2-0.81.51.1-1.01.30.7-0.8
Stereotopy head waving duration, day 34.75.68.52.4-2.22.92.5-2.42.92.2-0.8
Locomotion velocity, session 70.10.10.5-0.40.3-0.2-0.40.1-0.00.30.7
Locomotion distance, session 71.21.52.4-1.41.5-1.4-1.51.2-1.2-0.80.1
Stereotopy head waving bouts, day 73.64.06.52.0-2.22.42.2-2.12.51.30.5
Stereotopy head waving duration, day 73.03.65.31.9-2.12.12.1-2.02.31.50.5
Locomotion velocity, session 85.36.39.42.5-2.82.42.6-2.83.12.3-1.1
Locomotion distance, session 80.81.11.71.1-1.11.10.9-1.21.31.1-0.0
Degree of sensitization distance1.31.32.91.0-0.91.00.9-1.11.41.0-1.7
Degree of sensitization stereotypy3.03.34.81.8-2.11.92.0-1.92.21.40.6
Conditioned locomotion0.20.21.00.4-0.40.30.3-0.20.30.01.0
Cocaine response after cond. corrected0.00.10.20.4-0.00.20.1-0.1-0.1-0.10.4
Cocaine response after cond. not corrected0.10.10.20.4-0.10.30.2-0.1-0.0-0.10.5
Cocaine response before conditioning0.00.00.2-0.20.1-0.1-0.20.2-0.1-0.40.2
Saline control response0.40.51.11.0-0.71.10.6-0.60.90.00.6
Bone: connectivity density0.10.20.4-0.40.6-0.3-0.60.4-0.7-0.3-0.5
Bone: cortical apparent density1.52.13.0-1.51.5-1.3-1.61.6-1.5-1.70.5
Bone: cortical area1.72.63.71.9-1.71.91.6-1.61.91.0-0.8
Bone: cortical porosity0.20.20.20.4-0.50.40.5-0.40.30.50.0
Bone: cortical porosity1.31.42.11.4-1.31.41.3-1.21.21.0-0.2
Bone: cortical thickness0.30.52.00.7-0.60.30.4-0.30.6-0.0-1.4
Bone: cortical thickness0.60.71.80.8-0.80.20.8-0.70.70.8-1.3
Bone: cortical tissue density1.41.92.7-1.51.4-1.2-1.51.5-1.5-1.60.4
Condit. Reinf. active minus inactive responses1.01.13.9-0.70.9-0.2-1.01.2-0.9-2.0-0.7
Condit. Reinf. active-inactive response ratio0.20.20.80.5-0.30.90.2-0.20.5-0.3-0.4
Condit. Reinf. active responses2.63.27.0-1.61.9-1.3-1.92.0-1.8-2.6-0.2
Condit. Reinf. inactive responses3.44.25.3-2.22.2-2.3-2.22.1-2.1-2.10.4
Incentive salience index mean1.72.05.4-1.21.4-0.7-1.51.6-1.4-2.3-0.6
Condit. Reinf. lever presses2.02.75.9-1.71.7-1.2-1.91.8-1.4-2.4-0.0
Condit. Reinf. active minus inactive responses0.40.63.20.2-0.30.70.2-0.30.7-0.2-1.8
Condit. Reinf. active-inactive response ratio0.70.84.30.4-0.50.90.3-0.40.7-0.3-2.1
Condit. Reinf. active responses1.01.42.91.0-1.01.40.9-1.01.70.4-1.4
Condit. Reinf. inactive responses0.70.91.90.8-0.91.10.9-1.01.40.80.0
Condit. Reinf. lever presses0.20.31.1-0.30.40.1-0.40.30.1-0.8-1.1
Condit. Reinf. lever reinforcers received0.50.72.00.6-0.51.10.4-0.61.2-0.2-1.4
Conditioned reinforcement - actives0.10.20.30.4-0.00.5-0.50.1-0.6-0.4-0.6
Conditioned reinforcement - inactives0.30.53.10.3-0.00.40.0-0.40.10.5-1.7
Conditioned locomotion0.50.61.21.1-0.90.90.6-0.70.50.4-1.0
Patch foraging indifference point 0 sec0.10.20.7-0.40.5-0.2-0.60.3-0.40.2-0.8
Patch foraging indifference point AUC0.30.51.0-0.20.7-0.4-0.90.7-1.0-0.90.3
Delay disc. indifference point, 0s delay0.30.30.90.8-0.50.90.4-0.60.30.5-0.3
Delay disc. indifference point, 16s delay2.02.24.8-1.21.4-1.4-1.41.7-1.5-2.20.3
Delay disc. indifference point, 2s delay0.40.51.0-0.40.9-0.4-0.80.7-1.0-0.50.3
Delay disc. indifference point, 24s delay0.40.51.1-0.40.6-0.5-0.80.8-0.7-1.10.6
Delay disc. indifference point, 4s delay0.30.31.20.40.40.3-0.40.3-0.5-0.4-1.1
Delay disc. indifference point, 8s delay2.02.33.3-1.41.5-1.5-1.61.7-1.8-1.80.6
Indifference point function ln k0.91.52.30.8-1.31.01.5-1.21.51.5-0.5
Indifference point function log k0.91.52.30.8-1.31.01.5-1.21.51.5-0.5
Patch foraging total patch changes 0 sec0.20.30.5-0.50.7-0.4-0.70.4-0.50.1-0.7
Patch foraging total patch changes 12 sec0.10.10.40.20.10.5-0.2-0.20.10.1-0.6
Patch foraging total patch changes 18 sec0.10.21.0-0.0-0.00.2-0.20.10.0-0.3-1.0
Patch foraging total patch changes 24 sec0.20.30.9-0.20.8-0.1-1.00.5-0.7-0.20.1
Patch foraging total patch changes 6 sec0.10.21.20.50.00.3-0.2-0.1-0.10.1-1.1
Patch foraging time to switch 0 sec0.20.51.2-0.90.5-0.4-0.50.7-0.4-1.10.7
Patch foraging water rate 0 sec0.61.23.31.0-0.90.60.9-1.10.71.8-1.3
Patch foraging water rate 12 sec0.20.41.9-0.2-0.3-0.10.6-0.60.71.4-0.1
Patch foraging water rate 18 sec0.00.10.2-0.50.20.0-0.20.1-0.1-0.1-0.5
Patch foraging water rate 24 sec1.92.63.81.0-1.81.31.9-1.71.91.7-1.4
Patch foraging water rate 6 sec0.20.30.6-0.50.7-0.3-0.80.6-0.4-0.40.6
Seeking ratio, delayed vs. immediate footshock2.83.45.9-2.42.4-2.2-1.91.8-1.7-0.80.2
Distance traveled before self-admin0.30.50.7-0.80.7-0.8-0.90.6-0.5-0.2-0.8
Distance traveled after self-admin0.30.32.00.2-0.20.3-0.1-0.20.30.4-1.4
Extensor digitorum longus weight0.00.10.8-0.0-0.2-0.30.2-0.2-0.20.90.2
Bone: elastic displacement1.11.31.71.1-1.21.11.1-1.31.21.30.3
Bone: elastic work4.15.36.52.5-2.42.62.3-2.52.32.4-1.2
Bone: endosteal estimation1.43.15.91.8-1.62.41.6-1.92.01.60.4
Bone: endosteal perimeter1.53.35.91.9-1.72.41.7-1.82.11.41.2
Epididymis fat weight0.93.14.62.0-2.02.11.8-1.81.91.3-0.7
Delta time in closed arm before/after self-admin0.20.20.50.10.2-0.1-0.50.4-0.6-0.7-0.3
Delta time in open arm before/after self-admin0.40.41.2-0.2-0.20.00.4-0.60.51.10.9
Diff in mean of infusions in LGA sessions0.20.20.50.5-0.70.60.3-0.20.2-0.6-0.4
Delay discount exponential model param1.11.22.30.7-1.10.91.1-1.31.31.5-0.3
Extinction: sum of active levers before priming0.50.51.51.2-0.51.20.5-0.60.30.1-0.7
Active lever presses in extinction session 60.60.61.00.8-1.00.90.7-0.80.80.6-0.2
Bone: final force1.01.62.21.5-1.21.41.1-1.21.30.7-1.5
Bone: final moment1.42.33.21.8-1.51.71.4-1.51.51.1-1.6
Food consumed during 24 hour testing period1.82.44.11.2-1.71.41.6-1.71.52.0-1.1
Glucose0.20.30.5-0.60.7-0.6-0.60.6-0.7-0.1-0.3
Heart weight9.214.219.24.2-4.43.94.1-4.03.63.6-1.6
Delay discount hyperbolic model param0.80.91.70.5-1.00.71.0-1.11.21.3-0.2
Intermittent access intake day 1-15 change0.30.50.8-0.80.8-0.8-0.50.9-0.9-0.7-0.1
Intermittent access intake escalation0.30.71.1-0.80.9-0.9-0.71.0-1.1-0.90.0
Intermittent access intake escalation 21.11.32.0-1.21.2-1.1-1.11.2-1.4-1.10.4
Intermitt. access day 1 inactive lever presses0.20.83.80.8-0.60.90.3-0.70.50.3-1.9
Intermitt. access day 15 inactive lever presses0.40.85.60.5-0.20.50.1-0.30.30.2-2.4
Intermitt. access escalation Index0.20.30.7-0.10.8-0.4-0.60.6-0.6-0.3-0.3
Intermittent access day 1 total infusions0.40.61.30.8-0.60.60.5-0.70.60.9-1.2
Intermittent access day 15 total infusions0.10.20.4-0.40.6-0.5-0.50.5-0.6-0.0-0.2
Intermittent access terminal intake (last 3 days)0.30.41.0-0.60.7-0.6-0.80.6-1.0-0.20.3
Intermittent access total infusions0.10.10.3-0.00.1-0.1-0.1-0.1-0.20.5-0.4
Intermittent access day 1 locomotion0.10.10.70.0-0.1-0.0-0.10.0-0.2-0.3-0.8
Intermittent access day 15 total locomotion0.10.10.30.1-0.4-0.10.4-0.20.10.2-0.6
Intermittent access total locomotion0.10.10.5-0.0-0.2-0.10.1-0.2-0.00.4-0.7
Intermittent access standard deviation0.00.10.5-0.0-0.1-0.00.1-0.1-0.10.2-0.7
Left kidney weight13.562.774.48.2-8.68.68.6-8.48.67.3-3.9
Right kidney weight14.566.075.78.3-8.78.68.7-8.68.77.9-4.7
Cocaine induced anxiety1.11.62.40.6-1.21.11.6-1.41.31.4-1.4
Post-drug Anxiety0.10.10.3-0.2-0.30.10.6-0.30.40.5-0.3
Baseline Anxiety2.02.43.4-1.31.4-1.5-1.61.6-1.4-1.41.8
Tail length0.10.41.5-0.60.4-0.6-0.10.6-0.1-0.31.2
Length with tail0.41.52.31.2-1.51.51.5-1.21.40.9-0.0
Length without tail1.34.27.92.4-2.22.81.8-2.01.71.0-1.9
Times rat made contact with spout1.21.33.30.9-1.20.61.3-1.31.01.8-0.7
Lifetime Intake0.30.41.60.4-0.20.40.3-0.50.21.0-1.3
Liver weight, left0.40.62.70.9-0.50.60.6-0.20.7-0.11.6
Liver weight, right0.91.62.21.5-1.41.41.4-1.01.30.31.4
Locomotor activity2.74.37.02.3-2.32.22.2-2.12.61.5-0.7
Locomotor testing distance0.10.10.4-0.30.3-0.4-0.40.40.1-0.60.1
Locomotor testing rearing0.40.82.01.4-0.91.10.8-0.80.90.40.1
Locomotion in novel chamber0.50.63.7-0.30.2-0.2-0.40.5-0.4-0.71.9
Locomotion in novel chamber post-restriction1.11.82.6-1.61.4-1.6-1.21.3-1.0-0.91.5
Fecal boli incidents, locomotor time 10.10.10.3-0.40.5-0.3-0.40.2-0.2-0.00.2
Change in fecal boli incidents, locomotor task0.80.81.61.0-1.20.61.1-0.91.10.40.1
Time >=10cm from walls, locomotor time 10.00.00.10.30.1-0.0-0.2-0.10.0-0.2-0.3
Bouts of movement, locomotor time 10.00.00.1-0.2-0.1-0.2-0.10.3-0.1-0.30.1
Total resting periods, locomotor time 10.10.10.2-0.50.2-0.5-0.30.5-0.3-0.3-0.1
Rest time, locomotor task time 10.10.10.4-0.10.1-0.2-0.1-0.10.00.5-0.6
Distance moved, locomotor task time 10.20.41.00.9-0.51.00.4-0.40.6-0.30.2
Vertical activity count, locomotor time 10.00.10.30.4-0.20.50.1-0.20.2-0.3-0.3
Time >=10cm from walls, locomotor time 20.40.60.8-0.60.6-0.8-0.80.8-0.8-0.90.7
Bouts of movement, locomotor time 20.10.20.6-0.10.2-0.1-0.30.5-0.4-0.8-0.6
Total resting periods, locomotor time 20.10.20.6-0.10.1-0.1-0.20.4-0.4-0.7-0.8
Rest time, locomotor task time 20.10.10.2-0.30.4-0.3-0.30.3-0.2-0.2-0.3
Distance moved, locomotor task time 20.40.50.90.7-0.90.60.7-0.80.80.40.6
Vertical activity count, locomotor time 20.30.40.70.5-0.80.60.7-0.70.70.20.3
Light reinforcement 10.20.61.60.3-0.51.00.9-0.71.30.60.4
Light reinforcement 20.40.62.10.3-0.40.71.1-0.71.40.70.1
Bone: marrow area1.63.56.61.9-1.72.61.7-2.12.11.70.3
Bone: maximum diameter4.88.912.23.2-3.13.53.1-3.13.42.7-1.0
Bone: maximum force1.93.44.82.2-1.82.01.8-1.91.81.5-1.7
Bone: maximum moment2.74.76.42.5-2.22.42.1-2.22.11.9-1.9
Mean time between licks in bursts0.41.02.1-0.80.9-1.5-1.01.0-1.1-0.70.7
Mean num. licks in bursts1.01.53.01.5-1.21.21.0-1.50.91.7-0.4
Cd content in liver1.21.33.01.7-1.30.91.1-1.10.71.4-0.1
Co content in liver0.40.50.80.8-0.80.00.9-0.50.40.9-0.7
Cu content in liver5.46.410.6-2.52.8-2.2-2.72.9-2.5-3.30.5
Fe content in liver2.02.44.31.7-1.52.11.5-1.61.61.1-1.1
K content in liver1.11.02.9-1.01.2-0.5-1.11.2-0.5-1.70.0
Mg content in liver1.41.53.1-1.31.4-0.7-1.31.4-0.7-1.8-0.5
Mn content in liver0.10.20.4-0.00.00.3-0.00.20.5-0.70.6
Na content in liver1.71.83.0-1.71.5-1.4-1.31.4-1.3-1.10.6
Rb content in liver0.50.61.10.8-0.71.00.6-0.60.8-0.2-1.0
Se content in liver0.70.92.2-0.70.9-0.5-1.01.1-0.8-1.50.7
Sr content in liver2.42.13.9-1.61.3-2.0-1.31.5-1.7-1.00.6
Zn content in liver0.00.00.00.10.10.1-0.10.1-0.20.20.2
Bone: minimum diameter0.50.92.31.0-1.01.50.9-0.91.20.40.2
Time in familiar zone, hab. session 10.10.10.4-0.1-0.2-0.00.2-0.30.30.50.6
Time in novel zone, hab. session 11.41.42.91.7-1.41.21.4-1.11.10.8-0.3
Total zone transitions, hab. session 12.23.14.5-2.12.0-1.9-1.71.8-1.4-1.71.4
Total locomotion distance, hab. session 10.81.23.9-1.31.0-0.8-0.80.9-0.4-0.82.0
Locomotion velocity, hab. session 11.11.62.8-1.71.4-1.0-1.21.1-0.7-0.91.7
Time in familiar zone, hab. session 20.50.53.3-0.40.2-0.5-0.00.4-0.1-0.31.8
Time in novel zone, hab. session 21.11.12.81.2-1.01.00.8-1.00.60.9-1.7
Total zone transitions, hab. session 20.20.30.8-0.90.7-0.4-0.70.30.0-0.4-0.3
Total locomotion distance, hab. session 20.20.31.0-1.00.7-0.7-0.60.4-0.3-0.20.0
Locomotion velocity, hab. session 20.60.82.0-1.41.1-1.1-1.00.8-0.6-0.50.2
Novel to familiar place preference ratio3.84.28.22.9-2.42.22.2-1.91.81.6-0.4
Novelty place preference4.85.19.83.1-2.72.42.5-2.22.11.8-0.2
Time in novel zone, NPP test6.26.612.03.5-3.02.72.8-2.52.42.2-0.3
Total zone transitions, NPP test1.01.53.0-1.71.3-1.4-1.11.0-0.9-1.01.0
Total locomotion distance, NPP test0.40.61.6-1.30.8-0.9-0.70.6-0.7-0.40.4
Locomotion velocity, NPP test1.52.14.1-2.01.5-1.6-1.41.4-1.4-1.21.0
Intraocular pressure0.20.30.80.2-0.60.30.6-0.60.40.90.4
Delta distance traveled before/after self-admin1.61.72.41.5-1.51.51.3-1.41.31.2-0.4
Delta ambulatory time before/after self-admin2.32.94.01.9-2.01.91.9-1.71.81.3-0.7
Parametrial fat weight0.61.33.2-0.61.0-1.1-0.91.2-1.2-1.01.8
Pavlov. Cond. lever latency1.62.04.21.3-1.51.01.6-1.61.32.1-0.1
Pavlov. Cond. magazine entry latency1.72.23.7-1.41.4-1.6-1.41.7-1.6-1.9-0.2
Pavlov. Cond. change in total contacts2.02.14.2-1.41.5-1.3-1.41.6-1.4-2.0-0.6
Pavlov. Cond. index score1.51.93.6-1.31.4-1.2-1.51.5-1.4-1.9-0.5
Pavlov. Cond. latency score1.21.63.3-1.11.2-1.1-1.31.4-1.2-1.8-0.4
Pavlov. Cond. lever contacts3.54.26.5-2.12.2-1.8-2.32.2-1.9-2.60.2
Pavlov. Cond. magazine entry number2.12.64.11.5-1.51.81.5-1.81.82.00.3
Pavlov. Cond. intertrial magazine entries0.40.51.1-0.40.7-0.6-0.80.7-1.0-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.2.02.44.1-1.51.6-1.4-1.71.7-1.6-2.0-0.3
Pavlov. Cond. response bias3.23.96.6-2.02.0-1.9-2.02.2-2.0-2.6-0.1
Pavlov. Cond. lever latency0.30.42.20.6-0.40.00.4-0.3-0.10.71.5
Pavlov. Cond. magazine entry latency2.63.24.5-1.91.8-1.5-1.81.7-1.7-1.7-2.1
Pavlov. Cond. change in total contacts0.81.29.0-0.20.40.4-0.40.1-0.0-0.6-3.0
Pavlov. Cond. index score1.21.74.4-1.31.2-0.8-1.21.1-0.8-1.3-2.1
Pavlov. Cond. latency score1.62.14.6-1.51.4-1.1-1.41.2-1.0-1.4-2.1
Pavlov. Cond. lever contacts0.40.52.1-0.70.6-0.1-0.50.5-0.0-0.9-1.5
Pavlov. Cond. magazine entry number1.82.24.31.5-1.51.01.5-1.31.21.62.1
Pavlov. Cond. intertrial magazine entries1.92.94.21.7-1.91.31.9-1.91.62.0-0.7
Pavlov. Cond. lever-magazine prob. diff.1.41.83.9-1.41.4-0.9-1.31.2-0.9-1.4-2.0
Pavlov. Cond. response bias0.70.93.5-0.90.8-0.3-0.70.7-0.3-1.1-1.9
Time in closed arm before self-admin3.64.66.3-2.52.4-2.4-2.22.2-2.1-1.71.3
Time in closed arm after self-admin1.11.22.2-0.80.7-0.9-1.21.2-1.2-1.51.2
Time in open arm before self-admin0.10.10.1-0.20.1-0.2-0.10.3-0.3-0.40.4
Time in open arm after self-admin0.30.31.2-0.1-0.10.10.6-0.50.51.10.6
Bone: periosteal estimation2.04.27.72.3-2.12.82.0-2.12.51.5-0.2
Bone: periosteal perimeter3.25.59.12.6-2.43.02.4-2.32.81.80.4
Bone: post-yield work0.40.61.20.6-0.70.50.6-0.80.41.1-1.1
Progressive ratio test 1 active lever presses0.20.21.30.1-0.10.10.1-0.20.10.4-1.1
Progressive ratio test 1 breakpoint0.10.10.9-0.1-0.0-0.1-0.1-0.0-0.00.2-0.9
Progressive ratio test 1 inactive lever presses0.50.84.50.3-0.30.50.4-0.60.30.8-2.1
Progressive ratio test 2 active lever presses0.30.31.5-0.0-0.10.10.3-0.40.10.8-1.2
Progressive ratio test 2 breakpoint0.20.21.1-0.1-0.00.00.2-0.3-0.00.7-1.1
Progressive ratio test 2 inactive lever presses0.30.51.4-0.80.8-0.7-0.50.5-0.6-0.2-1.2
Incentive Sensitization - Responses0.20.21.1-0.1-0.10.00.5-0.50.21.1-0.6
Incentive Sensitization - Breakpoint0.20.31.1-0.0-0.20.10.5-0.50.31.1-0.7
Sum of active levers in priming session hrs 5-60.10.10.20.3-0.30.4-0.0-0.20.1-0.30.2
Progressive ratio0.10.20.4-0.20.30.3-0.50.3-0.4-0.5-0.7
Food seeking constrained by brief footshock0.91.12.11.1-1.01.41.1-1.01.20.3-0.7
Seeking ratio, punishment vs. effort0.20.30.60.6-0.60.40.8-0.60.80.4-0.1
Retroperitoneal fat weight2.29.514.13.7-3.53.83.2-3.13.22.1-1.4
Reaction time number correct1.12.02.8-1.51.5-1.4-1.31.5-1.2-1.31.7
Reaction time mean minus median0.20.51.00.9-0.80.30.8-0.70.41.00.6
Reaction time mean minus median AUC0.41.12.31.2-1.20.41.2-1.00.71.50.6
Reaction time num false alarms0.20.31.70.3-0.30.40.3-0.20.20.01.3
Reaction time num false alarms AUC0.20.31.50.3-0.30.40.4-0.20.20.11.2
Reaction time trials correct on left1.12.02.8-1.51.5-1.4-1.31.5-1.2-1.31.7
Reaction time trials on left1.12.13.0-1.51.5-1.5-1.31.5-1.2-1.31.7
Reaction time mean0.00.00.1-0.0-0.1-0.30.20.10.1-0.10.0
Reaction time mean AUC0.00.00.1-0.1-0.1-0.30.30.10.2-0.10.1
Median of all reaction times0.10.10.2-0.40.2-0.5-0.00.40.0-0.5-0.1
Reaction time omissions0.10.21.2-0.1-0.3-0.30.20.10.2-0.31.1
Reaction time false alarm rate0.50.60.90.9-0.90.90.9-0.90.60.70.2
Reaction time premature initiation rate0.50.64.30.20.10.5-0.5-0.10.0-0.4-2.1
Reaction time premature initiations0.30.51.5-0.50.7-0.2-1.00.6-0.6-0.7-1.2
Std. dev. reaction times0.40.71.21.1-1.00.71.0-0.70.70.60.3
Reaction time trials completed1.12.13.0-1.51.5-1.5-1.31.5-1.2-1.31.7
Reaction time trials AUC0.91.62.3-1.41.4-1.2-1.11.4-1.0-1.11.5
Run reversals in cocaine runway, females1.41.42.7-0.91.0-0.9-1.21.3-0.9-1.71.4
Run reversals in cocaine runway, males1.41.42.01.2-1.31.21.2-1.41.21.40.1
Latency to leave start box in cocaine runway0.20.21.10.2-0.10.10.4-0.50.41.1-0.1
Latency to leave start box in cocaine runway, F0.10.10.5-0.20.4-0.4-0.1-0.0-0.10.70.3
Latency to leave start box in cocaine runway, M0.70.71.00.7-0.90.71.0-0.80.80.9-0.5
Std. dev. time between licks in bursts0.60.81.8-0.70.9-0.6-0.90.9-0.6-1.4-1.0
Total sessions with >9 infusions3.34.06.42.2-1.72.11.7-1.91.62.2-2.5
Short access day 1 total inactive lever presses3.44.56.22.1-2.02.02.1-2.12.12.0-2.5
Short access day 10 total inactive lever presses0.71.72.91.0-1.51.21.5-1.51.71.3-0.2
Short access day 1 total infusions2.12.83.61.9-1.41.81.3-1.61.51.9-1.9
Short access day 10 total infusions0.20.31.50.7-0.30.50.3-0.30.20.2-1.2
Short access total infusions2.22.86.11.6-1.31.61.4-1.51.41.8-2.5
Short access day 1 locomotion0.30.31.00.7-0.50.40.2-0.40.10.5-1.0
Short access day 10 total locomotion0.50.81.5-0.90.7-0.8-1.00.9-1.2-1.2-0.2
Short access total locomotion0.20.21.20.4-0.50.40.1-0.1-0.0-0.2-1.1
One hour access (0.3 mA shock)0.60.71.4-1.20.9-0.9-0.70.8-1.0-0.40.1
Compulsive drug intake0.10.20.60.1-0.30.70.2-0.30.2-0.3-0.8
One hour access (shock baseline)0.61.02.0-1.31.2-1.4-0.90.9-1.00.20.5
Social response proportion0.40.40.80.7-0.70.60.5-0.50.30.9-0.9
Social responses0.20.20.90.4-0.30.60.00.20.0-0.90.4
Social time1.82.44.0-1.61.3-1.6-1.71.7-2.0-1.50.6
Soleus weight0.10.30.80.2-0.3-0.00.3-0.60.30.9-0.8
Bone: stiffness0.71.21.71.3-1.01.31.1-1.11.00.7-1.1
Tibialis anterior weight0.31.22.7-1.01.1-1.6-1.11.0-1.5-0.3-0.2
Time to tail flick, vehicle, before self-admin0.50.51.00.9-1.00.90.6-0.70.60.2-0.5
Time to tail flick, vehicle, after self-admin0.30.41.9-0.3-0.3-0.4-0.20.3-0.3-0.61.4
Time to tail flick, test, before self-admin0.20.20.60.3-0.20.30.8-0.30.70.00.4
Time to tail flick, test, after self-admin1.11.11.6-0.81.2-1.0-1.31.0-1.2-0.91.0
Delta time to tail flick, vehicle, before/after SA0.20.20.30.3-0.50.20.5-0.50.40.5-0.1
Delta time to tail flick, test, before/after SA1.81.93.4-1.21.6-1.3-1.81.3-1.7-0.90.5
Tibia length0.92.54.11.6-1.82.01.7-1.61.71.1-1.0
Ambulatory time before self-admin0.10.20.3-0.60.4-0.5-0.50.3-0.30.2-0.5
Ambulatory time after self-admin0.10.10.4-0.10.0-0.2-0.30.00.00.2-0.6
Bone: tissue strength0.50.51.10.7-0.51.10.5-0.70.60.5-0.7
Total heroin consumption0.70.91.20.8-0.91.01.0-1.11.10.6-0.9
Bone: trabecular number0.40.60.8-0.80.9-0.6-0.90.7-0.9-0.50.8
Bone: trabecular spacing1.11.51.91.2-1.41.21.4-1.31.31.0-0.9
Bone: trabecular thickness0.40.60.9-0.70.8-0.7-0.90.9-0.7-0.80.0
Bone: trabecular tissue density0.60.91.6-0.90.9-1.1-1.01.1-0.9-1.3-0.4
Water consumed over 24 hours2.33.17.51.1-1.91.11.9-2.11.62.7-0.9
Number of responses in last shaping day0.90.91.5-1.00.9-1.0-1.00.9-1.0-0.8-1.2