Hub : Genes

Aqp5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Aqp5	0.1	0.06	7.1e-06	0.09	0.1	0.09	0.09	9.0e-05	5.4e-05	1.2e-04	8.8e-05
2	Brain	gene expression	Aqp5	0.04	0.04	3.4e-03	0.02	0.01	0.01	0.01	9.9e-03	1.7e-02	2.7e-02	1.4e-02
3	NAcc	gene expression	Aqp5	0.12	0.08	4.4e-16	0.15	0.14	0.13	0.14	6.7e-17	1.0e-15	2.9e-15	6.5e-16

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	7.6	12.7	14.9	-3.9	3.4	3.4
Area under the delay curve	1.0	1.1	1.2	-1.1	1.0	1.0
BMI with tail	4.3	13.9	15.4	-3.9	3.6	3.6
BMI without tail	0.2	0.3	0.4	-0.4	0.6	0.6
Body weight	4.8	20.3	23.6	-4.9	4.3	4.3
Weight adjusted by age	0.3	0.4	0.7	-0.9	0.4	0.4
Bone surface	10.2	18.0	20.2	-4.5	4.1	4.1
Bone volume	9.2	15.7	16.8	-4.1	3.9	3.9
Breakpoint value in progressive ratio session	0.1	0.1	0.1	-0.3	0.2	0.2
Number of licking bursts	1.3	1.5	1.5	1.2	-1.2	-1.2
Context. condit. distance diff. score	0.2	0.2	0.2	-0.5	0.4	0.4
Locomotion velocity, session 1	3.8	4.1	4.4	1.9	-2.1	-2.1
Locomotion distance, session 1	2.9	3.7	3.8	2.0	-1.9	-1.9
Locomotion velocity, session 2	0.3	0.3	0.3	0.6	-0.6	-0.6
Locomotion distance, session 2	3.1	4.3	4.3	2.1	-2.1	-2.1
Locomotion velocity, session 3	4.7	5.5	5.9	2.4	-2.3	-2.3
Locomotion distance, session 3	3.2	3.5	4.4	2.1	-1.8	-1.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.4	0.1	0.1
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.1	-0.2	-0.2
Locomotion velocity, session 7	2.8	3.0	3.3	1.5	-1.8	-1.8
Locomotion distance, session 7	4.1	5.3	5.4	2.2	-2.3	-2.3
Stereotopy head waving bouts, day 7	0.6	0.7	0.7	-0.8	0.9	0.9
Stereotopy head waving duration, day 7	1.3	1.5	1.5	-1.2	1.2	1.2
Locomotion velocity, session 8	0.3	0.4	0.4	0.5	-0.7	-0.7
Locomotion distance, session 8	1.2	1.8	1.9	1.4	-1.3	-1.3
Degree of sensitization distance	0.0	0.0	0.0	-0.2	-0.0	-0.0
Degree of sensitization stereotypy	0.7	0.8	0.9	-0.7	1.0	1.0
Conditioned locomotion	0.0	0.0	0.0	0.0	-0.1	-0.1
Cocaine response after cond. corrected	0.0	0.0	0.0	-0.0	0.1	0.1
Cocaine response after cond. not corrected	0.2	0.2	0.3	0.6	-0.4	-0.4
Cocaine response before conditioning	2.2	2.7	3.2	1.8	-1.5	-1.5
Saline control response	0.0	0.0	0.0	-0.1	-0.1	-0.1
Bone: connectivity density	4.1	6.5	8.2	-2.9	2.4	2.4
Bone: cortical apparent density	0.2	0.2	0.3	0.5	-0.5	-0.5
Bone: cortical area	6.1	9.2	11.0	-3.3	2.9	2.9
Bone: cortical porosity	0.0	0.0	0.0	0.1	0.2	0.2
Bone: cortical porosity	0.0	0.0	0.1	0.4	-0.0	-0.0
Bone: cortical thickness	1.6	2.7	3.3	-1.8	1.5	1.5
Bone: cortical thickness	0.3	0.3	0.4	0.4	-0.6	-0.6
Bone: cortical tissue density	0.3	0.4	0.4	0.6	-0.6	-0.6
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	0.3	-0.3	-0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.3	0.3
Condit. Reinf. active responses	0.8	0.9	1.0	1.0	-1.0	-1.0
Condit. Reinf. inactive responses	2.8	3.3	3.6	1.9	-1.8	-1.8
Incentive salience index mean	0.0	0.0	0.0	-0.0	-0.0	-0.0
Condit. Reinf. lever presses	0.4	0.5	0.6	-0.7	0.8	0.8
Condit. Reinf. active minus inactive responses	0.9	1.1	1.3	-0.8	1.2	1.2
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.1	-0.5	1.0	1.0
Condit. Reinf. active responses	0.1	0.1	0.2	-0.1	0.4	0.4
Condit. Reinf. inactive responses	0.8	1.0	1.0	1.0	-1.0	-1.0
Condit. Reinf. lever presses	0.0	0.0	0.0	-0.0	0.0	0.0
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.3	-0.0	-0.0
Conditioned reinforcement - actives	1.2	1.2	1.4	1.2	-1.0	-1.0
Conditioned reinforcement - inactives	1.9	2.2	2.6	1.6	-1.4	-1.4
Conditioned locomotion	0.1	0.2	0.2	0.5	-0.4	-0.4
Patch foraging indifference point 0 sec	6.4	10.3	11.0	3.0	-3.3	-3.3
Patch foraging indifference point AUC	0.1	0.1	0.3	0.5	-0.3	-0.3
Delay disc. indifference point, 0s delay	2.3	2.5	2.6	-1.5	1.6	1.6
Delay disc. indifference point, 16s delay	0.9	0.9	1.0	-1.0	0.9	0.9
Delay disc. indifference point, 2s delay	1.9	2.1	2.2	-1.5	1.4	1.4
Delay disc. indifference point, 24s delay	0.6	0.6	0.8	-0.9	0.7	0.7
Delay disc. indifference point, 4s delay	1.2	1.2	1.4	-1.0	1.2	1.2
Delay disc. indifference point, 8s delay	1.3	1.3	1.9	-1.4	1.0	1.0
Indifference point function ln k	4.5	6.3	7.3	-2.7	2.4	2.4
Indifference point function log k	4.5	6.3	7.3	-2.7	2.4	2.4
Patch foraging total patch changes 0 sec	6.0	9.6	10.2	2.9	-3.2	-3.2
Patch foraging total patch changes 12 sec	6.0	7.8	8.1	2.7	-2.8	-2.8
Patch foraging total patch changes 18 sec	7.4	9.4	9.5	3.1	-3.1	-3.1
Patch foraging total patch changes 24 sec	4.7	5.7	5.8	2.3	-2.4	-2.4
Patch foraging total patch changes 6 sec	6.7	10.0	10.2	3.1	-3.2	-3.2
Patch foraging time to switch 0 sec	2.4	3.8	4.0	2.0	-1.9	-1.9
Patch foraging water rate 0 sec	3.2	5.1	5.3	-2.3	2.2	2.2
Patch foraging water rate 12 sec	2.8	4.3	4.8	-2.2	2.0	2.0
Patch foraging water rate 18 sec	0.4	0.5	0.5	-0.7	0.7	0.7
Patch foraging water rate 24 sec	4.9	6.8	6.9	-2.6	2.6	2.6
Patch foraging water rate 6 sec	5.4	7.8	7.9	-2.8	2.8	2.8
Seeking ratio, delayed vs. immediate footshock	0.7	0.8	0.8	-0.8	0.9	0.9
Distance traveled before self-admin	2.3	2.5	2.5	1.6	-1.6	-1.6
Distance traveled after self-admin	0.5	0.5	0.5	0.7	-0.7	-0.7
Extensor digitorum longus weight	4.8	18.8	19.4	-4.4	4.3	4.3
Bone: elastic displacement	6.3	7.1	7.2	2.6	-2.7	-2.7
Bone: elastic work	0.0	0.0	0.0	-0.1	-0.0	-0.0
Bone: endosteal estimation	7.5	16.3	18.0	-4.2	3.9	3.9
Bone: endosteal perimeter	6.9	14.4	15.4	-3.9	3.7	3.7
Epididymis fat weight	0.0	0.0	0.1	-0.3	0.0	0.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	-0.4	0.2	0.2
Delta time in open arm before/after self-admin	3.5	3.4	4.0	2.0	-1.8	-1.8
Diff in mean of infusions in LGA sessions	1.1	1.2	1.7	-1.3	1.0	1.0
Delay discount exponential model param	1.0	1.1	1.2	1.1	-1.0	-1.0
Extinction: sum of active levers before priming	0.7	0.7	0.7	-0.8	0.8	0.8
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.4	0.3	0.3
Bone: final force	10.8	17.5	19.0	-4.4	4.1	4.1
Bone: final moment	12.3	19.9	21.4	-4.6	4.4	4.4
Food consumed during 24 hour testing period	1.4	1.7	2.0	-1.4	1.3	1.3
Glucose	0.3	0.4	0.5	0.5	-0.7	-0.7
Heart weight	0.0	0.1	0.1	-0.3	0.2	0.2
Delay discount hyperbolic model param	1.1	1.2	1.3	1.1	-1.1	-1.1
Intermittent access intake day 1-15 change	0.2	0.2	0.5	0.7	-0.3	-0.3
Intermittent access intake escalation	0.0	0.0	0.1	0.4	0.0	0.0
Intermittent access intake escalation 2	0.2	0.2	0.4	0.6	-0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.3	0.4	0.7	0.8	-0.5	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.3	0.5	-0.2	-0.2
Intermitt. access escalation Index	0.9	0.8	0.8	0.8	-0.9	-0.9
Intermittent access day 1 total infusions	1.3	1.5	1.6	1.3	-1.2	-1.2
Intermittent access day 15 total infusions	1.8	2.0	2.6	1.6	-1.3	-1.3
Intermittent access terminal intake (last 3 days)	1.8	2.0	2.6	1.6	-1.3	-1.3
Intermittent access total infusions	1.7	1.9	2.5	1.6	-1.3	-1.3
Intermittent access day 1 locomotion	1.5	1.6	1.6	1.2	-1.3	-1.3
Intermittent access day 15 total locomotion	1.3	1.4	1.6	1.3	-1.1	-1.1
Intermittent access total locomotion	4.0	4.6	4.8	2.2	-2.1	-2.1
Intermittent access standard deviation	0.0	0.0	0.0	0.2	0.1	0.1
Left kidney weight	0.9	2.5	2.7	-1.5	1.6	1.6
Right kidney weight	2.0	5.7	6.6	-2.6	2.3	2.3
Cocaine induced anxiety	0.8	0.9	1.1	-1.1	0.9	0.9
Post-drug Anxiety	5.1	5.7	6.1	-2.5	2.3	2.3
Baseline Anxiety	0.8	0.9	1.0	-1.0	0.9	0.9
Tail length	0.0	0.1	0.1	0.4	-0.2	-0.2
Length with tail	1.6	5.7	6.6	-2.6	2.3	2.3
Length without tail	4.9	10.6	13.1	-3.6	3.1	3.1
Times rat made contact with spout	0.0	0.0	0.0	0.2	-0.1	-0.1
Lifetime Intake	2.5	2.8	3.3	1.8	-1.6	-1.6
Liver weight, left	1.6	2.5	2.8	-1.7	1.5	1.5
Liver weight, right	1.4	2.4	2.6	-1.6	1.5	1.5
Locomotor activity	1.4	2.2	2.2	1.5	-1.5	-1.5
Locomotor testing distance	3.6	6.0	6.2	2.5	-2.4	-2.4
Locomotor testing rearing	2.4	3.7	4.0	2.0	-1.9	-1.9
Locomotion in novel chamber	2.5	3.1	3.3	-1.6	1.8	1.8
Locomotion in novel chamber post-restriction	0.5	0.6	0.7	-0.6	0.8	0.8
Fecal boli incidents, locomotor time 1	1.3	1.4	1.8	1.3	-1.1	-1.1
Change in fecal boli incidents, locomotor task	0.4	0.4	0.6	-0.8	0.5	0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.4	0.4	-0.6	-0.6
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.1	-0.0	-0.0
Total resting periods, locomotor time 1	0.4	0.4	0.5	0.6	-0.7	-0.7
Rest time, locomotor task time 1	0.8	0.9	0.9	0.9	-1.0	-1.0
Distance moved, locomotor task time 1	0.0	0.0	0.0	-0.0	0.1	0.1
Vertical activity count, locomotor time 1	1.2	1.2	1.3	-1.1	1.1	1.1
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.5	0.7	-0.5	-0.5
Bouts of movement, locomotor time 2	3.4	3.7	3.7	-1.9	1.9	1.9
Total resting periods, locomotor time 2	3.9	4.2	4.2	-2.0	2.1	2.1
Rest time, locomotor task time 2	0.1	0.1	0.1	0.2	-0.3	-0.3
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.2	-0.2	-0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.2	-0.2	0.5	0.5
Light reinforcement 1	0.9	1.6	2.6	1.6	-1.1	-1.1
Light reinforcement 2	0.1	0.1	0.1	0.2	0.3	0.3
Bone: marrow area	7.0	15.2	17.0	-4.1	3.8	3.8
Bone: maximum diameter	1.6	3.0	3.8	-2.0	1.6	1.6
Bone: maximum force	14.3	24.7	27.6	-5.3	4.8	4.8
Bone: maximum moment	16.1	27.7	30.5	-5.5	5.1	5.1
Mean time between licks in bursts	0.0	0.0	0.0	0.1	-0.0	-0.0
Mean num. licks in bursts	0.5	0.6	0.7	-0.7	0.8	0.8
Cd content in liver	0.5	0.6	0.7	0.8	-0.7	-0.7
Co content in liver	0.6	0.6	0.8	0.9	-0.7	-0.7
Cu content in liver	0.2	0.3	0.4	-0.6	0.5	0.5
Fe content in liver	0.8	1.0	1.0	1.0	-1.0	-1.0
K content in liver	0.0	0.0	0.1	0.1	-0.2	-0.2
Mg content in liver	0.2	0.2	0.2	0.5	-0.4	-0.4
Mn content in liver	0.1	0.1	0.1	-0.4	0.4	0.4
Na content in liver	0.2	0.2	0.2	0.5	-0.5	-0.5
Rb content in liver	2.2	2.7	2.9	1.5	-1.7	-1.7
Se content in liver	2.0	2.4	2.5	1.5	-1.6	-1.6
Sr content in liver	0.0	0.0	0.0	-0.1	0.1	0.1
Zn content in liver	3.0	3.3	3.4	1.8	-1.8	-1.8
Bone: minimum diameter	8.7	16.2	17.6	-4.2	3.9	3.9
Time in familiar zone, hab. session 1	0.0	0.0	0.0	0.1	0.2	0.2
Time in novel zone, hab. session 1	0.0	0.0	0.0	-0.2	0.0	0.0
Total zone transitions, hab. session 1	0.1	0.1	0.1	0.4	-0.2	-0.2
Total locomotion distance, hab. session 1	0.3	0.4	0.5	0.5	-0.7	-0.7
Locomotion velocity, hab. session 1	0.2	0.2	0.3	0.3	-0.6	-0.6
Time in familiar zone, hab. session 2	1.6	1.7	1.8	-1.2	1.3	1.3
Time in novel zone, hab. session 2	1.8	1.8	2.0	1.2	-1.4	-1.4
Total zone transitions, hab. session 2	0.2	0.3	0.3	0.6	-0.6	-0.6
Total locomotion distance, hab. session 2	0.4	0.5	0.6	0.6	-0.8	-0.8
Locomotion velocity, hab. session 2	0.2	0.3	0.4	0.5	-0.6	-0.6
Novel to familiar place preference ratio	1.4	1.4	1.7	-1.3	1.1	1.1
Novelty place preference	0.8	0.8	1.0	-1.0	0.8	0.8
Time in novel zone, NPP test	0.5	0.5	0.7	-0.9	0.7	0.7
Total zone transitions, NPP test	2.7	3.8	3.9	1.9	-2.0	-2.0
Total locomotion distance, NPP test	3.6	4.9	5.1	2.1	-2.3	-2.3
Locomotion velocity, NPP test	2.3	3.3	3.5	1.7	-1.9	-1.9
Intraocular pressure	5.1	7.1	8.7	3.0	-2.5	-2.5
Delta distance traveled before/after self-admin	0.2	0.2	0.2	-0.4	0.4	0.4
Delta ambulatory time before/after self-admin	0.1	0.1	0.1	-0.2	0.3	0.3
Parametrial fat weight	1.3	2.6	3.2	1.8	-1.5	-1.5
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.1	-0.4	-0.4
Pavlov. Cond. magazine entry latency	0.8	1.1	1.2	-0.8	1.1	1.1
Pavlov. Cond. change in total contacts	1.1	1.2	1.5	-0.8	1.2	1.2
Pavlov. Cond. index score	0.6	0.7	0.9	-0.6	0.9	0.9
Pavlov. Cond. latency score	0.4	0.5	0.7	-0.5	0.8	0.8
Pavlov. Cond. lever contacts	0.0	0.0	0.1	0.1	0.3	0.3
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.4	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	4.4	5.3	6.1	2.0	-2.5	-2.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.1	1.3	-0.9	1.1	1.1
Pavlov. Cond. response bias	0.2	0.2	0.3	-0.3	0.6	0.6
Pavlov. Cond. lever latency	0.8	1.1	1.3	-0.9	1.1	1.1
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.2	-0.3	-0.3
Pavlov. Cond. change in total contacts	0.4	0.6	0.9	-0.9	0.7	0.7
Pavlov. Cond. index score	0.3	0.4	0.5	0.3	-0.7	-0.7
Pavlov. Cond. latency score	0.3	0.3	0.5	0.2	-0.7	-0.7
Pavlov. Cond. lever contacts	0.7	1.0	1.0	0.9	-1.0	-1.0
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.5	0.0	0.0
Pavlov. Cond. intertrial magazine entries	2.4	3.1	4.2	2.0	-1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.0	-0.4	-0.4
Pavlov. Cond. response bias	0.3	0.4	0.5	0.6	-0.7	-0.7
Time in closed arm before self-admin	1.0	1.1	1.4	-1.2	1.0	1.0
Time in closed arm after self-admin	0.4	0.4	0.6	-0.8	0.6	0.6
Time in open arm before self-admin	0.1	0.1	0.2	-0.4	0.2	0.2
Time in open arm after self-admin	0.2	0.2	0.3	0.5	-0.4	-0.4
Bone: periosteal estimation	9.6	19.8	22.5	-4.7	4.3	4.3
Bone: periosteal perimeter	9.4	15.6	17.1	-4.1	3.9	3.9
Bone: post-yield work	8.2	11.2	13.0	-3.6	3.2	3.2
Progressive ratio test 1 active lever presses	8.4	8.7	8.9	3.0	-2.9	-2.9
Progressive ratio test 1 breakpoint	7.1	7.4	7.7	2.8	-2.7	-2.7
Progressive ratio test 1 inactive lever presses	2.3	2.5	3.0	1.7	-1.5	-1.5
Progressive ratio test 2 active lever presses	2.1	2.3	2.7	1.6	-1.4	-1.4
Progressive ratio test 2 breakpoint	2.4	2.6	3.2	1.8	-1.5	-1.5
Progressive ratio test 2 inactive lever presses	1.2	1.4	1.9	1.4	-1.1	-1.1
Incentive Sensitization - Responses	0.2	0.2	0.3	-0.4	0.5	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.2	-0.3	0.4	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	0.5	-0.6	-0.6
Progressive ratio	0.9	1.1	1.2	0.9	-1.1	-1.1
Food seeking constrained by brief footshock	1.6	2.0	2.1	1.3	-1.5	-1.5
Seeking ratio, punishment vs. effort	0.1	0.1	0.1	-0.3	0.4	0.4
Retroperitoneal fat weight	1.1	3.6	3.6	1.8	-1.9	-1.9
Reaction time number correct	1.3	1.8	2.1	-1.4	1.3	1.3
Reaction time mean minus median	6.2	8.1	9.3	3.1	-2.7	-2.7
Reaction time mean minus median AUC	4.4	5.7	6.5	2.5	-2.3	-2.3
Reaction time num false alarms	1.5	2.1	2.2	1.5	-1.4	-1.4
Reaction time num false alarms AUC	1.8	2.5	2.7	1.6	-1.5	-1.5
Reaction time trials correct on left	1.3	1.8	2.1	-1.4	1.3	1.3
Reaction time trials on left	1.0	1.4	1.6	-1.3	1.1	1.1
Reaction time mean	0.7	1.0	1.1	1.0	-1.0	-1.0
Reaction time mean AUC	0.4	0.6	0.6	0.8	-0.8	-0.8
Median of all reaction times	0.0	0.0	0.0	0.1	-0.1	-0.1
Reaction time omissions	8.0	10.9	12.4	3.5	-3.2	-3.2
Reaction time false alarm rate	2.0	2.9	3.2	1.8	-1.6	-1.6
Reaction time premature initiation rate	4.9	6.5	7.5	2.7	-2.5	-2.5
Reaction time premature initiations	2.0	2.8	3.2	1.8	-1.6	-1.6
Std. dev. reaction times	5.2	7.3	8.2	2.9	-2.6	-2.6
Reaction time trials completed	1.0	1.4	1.6	-1.3	1.1	1.1
Reaction time trials AUC	1.6	2.3	2.7	-1.6	1.5	1.5
Run reversals in cocaine runway, females	0.5	0.5	0.6	-0.6	0.8	0.8
Run reversals in cocaine runway, males	0.7	0.7	1.0	1.0	-0.7	-0.7
Latency to leave start box in cocaine runway	0.0	0.0	0.0	0.1	-0.2	-0.2
Latency to leave start box in cocaine runway, F	1.7	1.9	2.0	1.4	-1.4	-1.4
Latency to leave start box in cocaine runway, M	2.1	2.0	2.4	-1.5	1.4	1.4
Std. dev. time between licks in bursts	1.2	1.5	1.8	1.3	-1.1	-1.1
Total sessions with >9 infusions	1.6	1.7	1.9	1.4	-1.3	-1.3
Short access day 1 total inactive lever presses	1.3	1.5	1.7	1.3	-1.2	-1.2
Short access day 10 total inactive lever presses	0.1	0.1	0.1	-0.1	0.3	0.3
Short access day 1 total infusions	0.6	0.7	0.7	0.7	-0.9	-0.9
Short access day 10 total infusions	2.6	2.9	2.9	1.7	-1.7	-1.7
Short access total infusions	1.8	2.0	2.0	1.4	-1.4	-1.4
Short access day 1 locomotion	0.3	0.3	0.3	0.5	-0.5	-0.5
Short access day 10 total locomotion	0.2	0.2	0.2	0.4	-0.5	-0.5
Short access total locomotion	0.5	0.5	0.6	0.8	-0.7	-0.7
One hour access (0.3 mA shock)	0.0	0.0	0.0	0.1	0.2	0.2
Compulsive drug intake	1.7	1.7	1.9	-1.4	1.3	1.3
One hour access (shock baseline)	0.0	0.0	0.0	0.2	0.1	0.1
Social response proportion	0.1	0.1	0.1	0.4	-0.2	-0.2
Social responses	5.7	7.3	8.8	3.0	-2.6	-2.6
Social time	0.2	0.2	0.3	-0.5	0.5	0.5
Soleus weight	1.0	2.9	3.0	-1.7	1.7	1.7
Bone: stiffness	18.5	29.3	31.4	-5.6	5.3	5.3
Tibialis anterior weight	2.8	9.5	10.2	-2.9	3.2	3.2
Time to tail flick, vehicle, before self-admin	0.8	0.9	0.9	0.9	-0.9	-0.9
Time to tail flick, vehicle, after self-admin	0.5	0.5	0.6	-0.8	0.7	0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3
Time to tail flick, test, after self-admin	0.9	0.9	1.0	-0.8	1.0	1.0
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	0.8	-0.9	0.9	0.9
Delta time to tail flick, test, before/after SA	0.8	0.7	0.8	-0.8	0.9	0.9
Tibia length	4.6	13.0	15.2	-3.9	3.4	3.4
Ambulatory time before self-admin	4.4	4.5	4.8	2.2	-2.1	-2.1
Ambulatory time after self-admin	1.8	2.0	2.3	1.5	-1.3	-1.3
Bone: tissue strength	2.0	1.9	2.1	-1.4	1.4	1.4
Total heroin consumption	1.1	1.3	1.7	-1.3	1.0	1.0
Bone: trabecular number	4.3	6.7	8.1	-2.8	2.4	2.4
Bone: trabecular spacing	1.4	1.8	2.3	1.5	-1.2	-1.2
Bone: trabecular thickness	0.5	0.5	0.7	-0.5	0.8	0.8
Bone: trabecular tissue density	0.6	0.9	1.1	-0.7	1.1	1.1
Water consumed over 24 hours	0.1	0.1	0.1	0.2	-0.4	-0.4
Number of responses in last shaping day	0.4	0.4	0.5	-0.5	0.7	0.7