Hub : Genes

Apom

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Apom 0.06 0.03 9.4e-09 0.06 0.05 0.06 0.04 1.8e-07 2.7e-06 4.0e-07 2.5e-05
2 pVTA intron excision ratio chr20_3695809_3696076 0.07 0.04 1.6e-04 0.07 0.05 0.04 0.05 1.8e-06 6.6e-05 5.2e-04 5.4e-05
3 IC intron excision ratio chr20_3695809_3696076 0.1 0.07 4.9e-03 0.06 0.02 0.01 0.03 1.7e-03 7.1e-02 1.5e-01 2.4e-02
4 NAcc intron excision ratio chr20_3695809_3696076 0.08 0.06 4.4e-07 0.05 0.05 0.04 0.05 4.4e-08 1.5e-07 7.9e-07 6.8e-08
5 Adipose gene expression Apom 0.07 0.04 1.2e-10 0.07 0.08 0.07 0.08 2.8e-08 3.7e-09 1.4e-08 2.5e-09
6 PL gene expression Apom 0.02 0.01 2.5e-03 0.02 0.02 0.01 0.01 2.6e-03 5.0e-03 1.2e-02 1.2e-02
7 NAcc gene expression Apom 0.05 0.03 1.2e-06 0.04 0.04 0.03 0.03 8.0e-07 8.0e-07 8.3e-05 3.1e-05
8 Liver gene expression Apom 0.38 0.13 7.4e-10 0.04 0.03 0.08 0.08 5.5e-05 9.8e-05 5.5e-09 1.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.73.13.8-1.9-1.9-1.9-1.7-1.61.71.71.7
Area under the delay curve0.40.72.21.20.60.80.80.3-0.3-0.3-1.5
BMI with tail0.82.85.52.3-1.7-1.4-1.32.2-1.7-1.6-0.5
BMI without tail1.15.611.03.1-1.8-0.8-0.73.3-3.0-3.0-1.5
Body weight2.611.428.95.40.80.81.04.1-4.1-4.1-3.0
Weight adjusted by age1.23.67.31.80.70.81.02.4-2.2-2.3-2.7
Bone surface0.10.20.50.30.30.30.7-0.1-0.2-0.20.7
Bone volume0.10.30.9-0.0-0.9-0.7-0.4-0.10.10.10.8
Breakpoint value in progressive ratio session0.10.20.5-0.6-0.00.00.3-0.70.40.40.5
Number of licking bursts0.41.33.60.11.91.71.6-0.70.40.50.3
Context. condit. distance diff. score3.23.87.1-2.70.91.61.8-2.42.32.21.0
Locomotion velocity, session 10.20.30.5-0.50.50.70.6-0.60.40.4-0.4
Locomotion distance, session 10.91.21.9-0.6-0.7-1.0-1.0-1.41.31.31.0
Locomotion velocity, session 20.30.40.7-0.00.70.50.5-0.80.80.60.5
Locomotion distance, session 20.81.23.0-0.80.1-0.4-0.5-1.71.61.50.6
Locomotion velocity, session 30.30.31.20.0-1.1-0.7-0.80.4-0.3-0.30.4
Locomotion distance, session 31.71.93.4-1.5-0.9-0.8-0.7-1.71.81.81.3
Stereotopy head waving bouts, day 31.82.23.11.71.71.71.71.0-1.2-1.1-1.4
Stereotopy head waving duration, day 32.02.43.21.51.41.41.31.6-1.7-1.6-1.8
Locomotion velocity, session 74.14.58.6-2.5-1.2-1.0-0.8-2.92.92.91.2
Locomotion distance, session 74.55.711.4-2.5-1.5-1.1-1.1-3.43.33.31.3
Stereotopy head waving bouts, day 70.80.94.02.00.70.40.50.7-0.8-0.7-0.9
Stereotopy head waving duration, day 70.91.14.02.00.60.40.51.1-1.1-1.0-0.9
Locomotion velocity, session 82.93.510.40.23.22.82.8-0.90.60.5-0.2
Locomotion distance, session 83.14.69.4-2.40.71.01.2-3.13.02.81.4
Degree of sensitization distance0.50.51.3-0.21.01.11.1-0.60.20.2-0.1
Degree of sensitization stereotypy0.20.21.41.20.2-0.10.00.0-0.1-0.1-0.1
Conditioned locomotion0.50.60.80.90.80.90.90.7-0.9-0.9-0.4
Cocaine response after cond. corrected0.60.92.7-0.7-0.40.10.2-1.21.11.11.6
Cocaine response after cond. not corrected0.40.51.70.40.71.21.3-0.1-0.1-0.20.7
Cocaine response before conditioning4.35.27.92.51.81.71.62.5-2.7-2.8-2.2
Saline control response2.33.15.91.2-1.7-1.5-1.62.4-2.0-2.1-1.3
Bone: connectivity density1.32.15.2-2.3-0.8-1.2-1.0-1.31.41.51.7
Bone: cortical apparent density0.61.02.60.1-1.6-1.5-1.40.8-0.5-0.50.3
Bone: cortical area0.30.52.71.60.30.40.60.3-0.4-0.50.2
Bone: cortical porosity0.60.73.00.90.30.40.30.6-0.6-0.7-1.7
Bone: cortical porosity1.01.13.91.11.11.00.90.5-0.7-0.7-2.0
Bone: cortical thickness0.91.53.41.7-1.8-1.7-1.60.4-0.2-0.30.5
Bone: cortical thickness1.31.63.90.8-2.0-2.0-1.90.6-0.3-0.40.8
Bone: cortical tissue density0.60.92.30.0-1.5-1.3-1.30.8-0.6-0.50.2
Condit. Reinf. active minus inactive responses0.40.51.6-1.3-0.3-0.4-0.4-0.80.70.70.1
Condit. Reinf. active-inactive response ratio0.20.20.60.1-0.4-0.8-0.70.4-0.3-0.3-0.2
Condit. Reinf. active responses0.91.23.5-1.9-0.7-0.9-1.0-1.11.11.00.6
Condit. Reinf. inactive responses2.43.15.3-2.3-1.3-1.6-1.7-1.81.81.81.5
Incentive salience index mean1.21.53.6-1.60.70.50.5-1.91.61.50.5
Condit. Reinf. lever presses2.23.37.2-1.91.31.21.3-2.72.22.11.3
Condit. Reinf. active minus inactive responses1.01.53.11.00.80.70.71.4-1.8-1.7-1.3
Condit. Reinf. active-inactive response ratio1.62.53.41.61.31.51.51.5-1.8-1.8-1.6
Condit. Reinf. active responses0.20.30.9-0.50.00.10.20.7-0.9-0.9-0.2
Condit. Reinf. inactive responses0.60.93.1-1.8-0.9-1.1-1.0-0.00.20.21.2
Condit. Reinf. lever presses0.10.21.2-1.10.1-0.2-0.30.0-0.10.00.2
Condit. Reinf. lever reinforcers received0.20.30.7-0.70.30.20.30.6-0.8-0.7-0.1
Conditioned reinforcement - actives0.10.51.91.0-0.3-1.4-0.80.00.40.3-0.4
Conditioned reinforcement - inactives0.20.51.20.9-0.9-0.8-0.70.5-0.10.0-1.1
Conditioned locomotion0.30.41.60.21.3-0.40.10.10.60.6-0.8
Patch foraging indifference point 0 sec0.71.93.40.8-1.1-1.2-1.31.9-1.7-1.7-1.1
Patch foraging indifference point AUC0.10.31.01.00.40.50.60.3-0.5-0.6-0.0
Delay disc. indifference point, 0s delay0.50.51.10.61.01.11.0-0.40.20.2-0.8
Delay disc. indifference point, 16s delay0.20.31.11.0-0.5-0.3-0.40.4-0.2-0.2-1.0
Delay disc. indifference point, 2s delay2.12.34.21.81.71.61.70.7-1.0-1.1-2.0
Delay disc. indifference point, 24s delay0.61.03.90.9-0.40.50.21.1-0.8-0.8-2.0
Delay disc. indifference point, 4s delay1.21.21.51.21.20.90.81.1-1.2-1.2-1.1
Delay disc. indifference point, 8s delay0.20.31.10.40.30.40.5-0.40.40.4-1.0
Indifference point function ln k0.20.61.8-0.01.31.01.0-0.60.40.4-0.3
Indifference point function log k0.20.61.8-0.01.31.01.0-0.60.40.4-0.3
Patch foraging total patch changes 0 sec0.72.13.51.0-1.1-1.2-1.51.9-1.7-1.8-1.2
Patch foraging total patch changes 12 sec0.91.22.31.0-1.0-0.9-1.01.5-1.2-1.2-0.1
Patch foraging total patch changes 18 sec0.92.15.8-0.1-2.1-2.4-2.40.6-0.5-0.40.7
Patch foraging total patch changes 24 sec0.72.37.2-0.7-2.7-2.2-2.3-0.00.50.50.5
Patch foraging total patch changes 6 sec1.11.93.01.0-1.6-1.4-1.71.7-1.2-1.3-1.1
Patch foraging time to switch 0 sec0.20.82.0-0.6-1.4-1.2-1.20.30.10.10.7
Patch foraging water rate 0 sec0.20.92.61.50.80.50.20.5-0.8-0.8-1.6
Patch foraging water rate 12 sec0.20.71.6-0.6-1.3-1.1-1.1-0.60.60.60.6
Patch foraging water rate 18 sec0.10.20.70.1-0.1-0.3-0.30.6-0.3-0.2-0.8
Patch foraging water rate 24 sec0.20.32.01.40.0-0.6-0.30.2-0.4-0.4-0.1
Patch foraging water rate 6 sec0.10.10.40.2-0.5-0.5-0.6-0.30.20.1-0.1
Seeking ratio, delayed vs. immediate footshock0.40.61.50.2-0.40.1-0.10.7-1.1-1.21.2
Distance traveled before self-admin0.20.30.8-0.10.80.70.60.10.30.50.9
Distance traveled after self-admin0.50.92.21.10.40.70.61.5-1.2-1.20.3
Extensor digitorum longus weight0.10.51.30.20.81.21.10.4-0.4-0.5-0.3
Bone: elastic displacement0.40.51.20.5-0.6-0.9-1.10.2-0.1-0.1-1.1
Bone: elastic work0.70.93.71.9-0.0-0.2-0.30.6-0.8-0.8-1.3
Bone: endosteal estimation3.58.713.62.33.73.63.62.3-2.8-2.7-1.8
Bone: endosteal perimeter1.63.910.30.53.03.23.20.4-0.8-0.8-0.2
Epididymis fat weight2.412.130.91.4-5.2-5.3-5.62.2-1.4-1.40.0
Delta time in closed arm before/after self-admin0.80.71.61.10.40.10.30.9-1.3-1.2-0.8
Delta time in open arm before/after self-admin0.20.20.6-0.1-0.2-0.6-0.60.20.50.70.1
Diff in mean of infusions in LGA sessions2.24.07.5-2.3-0.4-0.4-0.2-2.62.62.72.3
Delay discount exponential model param0.60.82.4-1.2-0.7-0.8-0.8-0.50.50.51.6
Extinction: sum of active levers before priming0.20.31.2-0.40.70.41.1-0.5-0.2-0.1-0.0
Active lever presses in extinction session 60.60.61.9-0.2-1.4-1.0-0.70.10.00.2-1.3
Bone: final force1.52.410.43.2-0.3-0.6-0.51.7-1.6-1.6-0.6
Bone: final moment1.42.28.73.0-0.4-0.6-0.41.7-1.5-1.6-0.7
Food consumed during 24 hour testing period0.20.51.30.90.31.01.10.5-0.4-0.5-0.2
Glucose3.04.813.0-1.03.33.63.4-0.70.50.4-1.0
Heart weight2.74.37.12.71.31.31.02.3-2.4-2.4-2.6
Delay discount hyperbolic model param0.70.92.5-1.3-0.8-0.9-0.9-0.50.60.61.6
Intermittent access intake day 1-15 change0.00.21.1-0.3-0.4-0.6-0.4-0.10.10.11.0
Intermittent access intake escalation0.10.61.4-0.4-1.0-1.2-1.10.2-0.0-0.01.0
Intermittent access intake escalation 20.10.10.4-0.3-0.4-0.1-0.0-0.2-0.2-0.20.6
Intermitt. access day 1 inactive lever presses0.11.23.11.11.21.71.8-0.0-0.7-0.7-0.2
Intermitt. access day 15 inactive lever presses0.21.02.31.5-0.00.30.21.0-1.3-1.4-0.8
Intermitt. access escalation Index0.82.64.9-1.7-0.00.20.2-2.12.22.21.9
Intermittent access day 1 total infusions0.51.43.5-0.6-1.0-1.2-0.6-1.11.91.7-0.4
Intermittent access day 15 total infusions0.51.12.8-0.5-1.3-1.7-1.2-0.51.11.00.4
Intermittent access terminal intake (last 3 days)0.30.51.40.2-1.2-1.2-0.70.10.60.5-0.4
Intermittent access total infusions0.70.81.7-0.1-0.9-1.3-0.7-0.31.31.1-0.4
Intermittent access day 1 locomotion0.50.91.9-0.9-0.6-1.2-0.7-0.41.41.30.2
Intermittent access day 15 total locomotion0.10.20.40.60.1-0.5-0.40.50.50.3-0.3
Intermittent access total locomotion0.30.41.40.3-0.3-1.2-0.80.20.70.5-0.4
Intermittent access standard deviation0.31.43.11.4-0.8-0.9-0.71.7-1.2-1.3-0.9
Left kidney weight1.29.322.74.8-0.3-0.10.13.9-3.9-3.9-2.3
Right kidney weight1.28.220.54.5-0.1-0.00.23.7-3.7-3.7-2.0
Cocaine induced anxiety0.20.61.0-0.71.00.90.7-0.50.60.61.0
Post-drug Anxiety0.30.30.7-0.40.90.80.50.3-0.5-0.40.6
Baseline Anxiety0.20.41.3-0.0-0.00.1-0.00.7-1.1-1.1-0.6
Tail length1.910.413.93.72.62.93.13.1-3.6-3.6-2.9
Length with tail3.314.721.64.63.43.13.43.6-4.1-4.2-3.8
Length without tail1.89.419.14.43.12.12.32.9-3.2-3.2-2.8
Times rat made contact with spout1.72.04.4-0.8-2.1-2.0-2.1-0.50.91.00.4
Lifetime Intake0.50.61.40.1-0.6-1.2-0.6-0.11.21.0-0.8
Liver weight, left1.52.66.30.92.22.32.51.1-1.0-1.1-0.4
Liver weight, right2.44.27.92.02.82.72.71.1-1.3-1.4-1.6
Locomotor activity1.52.35.31.12.31.21.61.4-1.7-1.6-0.7
Locomotor testing distance0.51.33.30.51.81.11.20.8-1.2-1.1-0.5
Locomotor testing rearing0.31.32.50.81.60.90.91.2-1.4-1.3-0.8
Locomotion in novel chamber0.10.10.40.7-0.10.3-0.30.1-0.2-0.20.2
Locomotion in novel chamber post-restriction0.41.12.01.2-0.70.20.11.4-1.4-1.4-0.9
Fecal boli incidents, locomotor time 10.10.20.7-0.90.0-0.3-0.60.2-0.2-0.3-0.6
Change in fecal boli incidents, locomotor task1.51.64.11.81.31.82.00.1-0.3-0.4-0.3
Time >=10cm from walls, locomotor time 11.51.82.61.51.41.61.51.4-1.2-1.3-0.4
Bouts of movement, locomotor time 10.60.81.5-1.10.4-0.0-0.1-1.01.21.21.2
Total resting periods, locomotor time 10.50.50.9-0.80.80.10.0-0.80.90.90.9
Rest time, locomotor task time 10.30.62.30.41.50.50.60.5-0.6-0.6-0.6
Distance moved, locomotor task time 10.10.30.91.0-0.8-0.2-0.00.4-0.4-0.4-0.3
Vertical activity count, locomotor time 10.00.30.60.7-0.8-0.7-0.60.4-0.4-0.4-0.1
Time >=10cm from walls, locomotor time 20.71.92.90.91.31.71.61.2-1.2-1.2-1.5
Bouts of movement, locomotor time 20.10.20.70.50.40.80.40.3-0.2-0.30.2
Total resting periods, locomotor time 20.10.41.80.40.81.30.90.2-0.1-0.20.2
Rest time, locomotor task time 20.61.12.8-0.21.71.61.4-0.50.50.50.6
Distance moved, locomotor task time 20.71.02.11.2-0.9-1.0-0.70.8-0.9-0.8-1.4
Vertical activity count, locomotor time 20.20.61.60.4-0.7-0.7-0.40.8-0.8-0.8-1.3
Light reinforcement 10.00.21.10.3-0.0-0.2-0.10.2-0.2-0.11.0
Light reinforcement 20.10.20.80.60.90.40.40.4-0.3-0.20.1
Bone: marrow area3.68.713.12.33.63.53.62.5-2.9-2.9-1.8
Bone: maximum diameter1.02.05.51.02.12.32.4-0.3-0.1-0.20.2
Bone: maximum force1.02.08.83.0-0.2-0.2-0.11.6-1.4-1.5-1.0
Bone: maximum moment1.01.97.42.7-0.2-0.10.01.5-1.4-1.4-1.1
Mean time between licks in bursts0.31.84.9-0.71.92.02.2-1.00.40.30.0
Mean num. licks in bursts1.02.78.1-0.4-2.9-2.6-2.50.60.0-0.0-0.1
Cd content in liver0.50.51.5-0.5-0.8-1.1-1.2-0.10.30.3-0.8
Co content in liver0.91.01.51.0-0.6-0.8-1.01.2-1.1-1.1-1.2
Cu content in liver2.53.04.4-2.1-1.7-2.1-1.9-1.01.41.42.0
Fe content in liver0.60.81.30.6-1.1-1.1-1.10.9-0.8-0.8-0.1
K content in liver0.70.61.6-0.2-0.5-0.1-0.0-1.11.00.91.3
Mg content in liver1.61.83.3-0.70.81.51.6-1.51.11.01.8
Mn content in liver2.12.35.3-1.12.12.32.3-1.20.70.70.6
Na content in liver0.50.62.60.4-0.3-0.7-0.6-0.80.60.61.6
Rb content in liver0.50.61.2-1.10.10.0-0.0-0.70.90.91.1
Se content in liver1.72.16.3-0.22.52.12.2-0.80.40.40.2
Sr content in liver1.31.14.10.91.30.60.50.7-0.8-0.8-2.0
Zn content in liver0.20.20.70.00.80.60.6-0.20.1-0.0-0.3
Bone: minimum diameter1.42.76.71.12.52.52.60.5-0.8-0.8-0.3
Time in familiar zone, hab. session 13.33.66.3-2.0-2.4-2.4-2.5-1.01.51.51.2
Time in novel zone, hab. session 12.62.94.61.62.02.02.11.3-1.6-1.6-1.3
Total zone transitions, hab. session 10.71.02.9-1.2-0.50.1-0.0-1.11.11.01.7
Total locomotion distance, hab. session 10.50.81.6-0.8-0.7-0.1-0.2-1.21.11.11.1
Locomotion velocity, hab. session 10.30.40.9-0.4-0.60.0-0.1-1.00.80.70.9
Time in familiar zone, hab. session 20.91.03.8-0.6-0.8-1.3-1.1-0.10.40.41.9
Time in novel zone, hab. session 20.80.94.40.6-0.00.60.40.7-0.7-0.7-2.1
Total zone transitions, hab. session 20.50.63.5-0.10.5-0.2-0.2-0.80.50.61.9
Total locomotion distance, hab. session 21.31.84.9-1.00.0-0.5-0.4-1.71.61.62.2
Locomotion velocity, hab. session 21.52.14.9-1.00.2-0.3-0.3-2.01.81.82.2
Novel to familiar place preference ratio0.10.10.40.1-0.40.1-0.1-0.40.30.3-0.6
Novelty place preference0.10.10.50.4-0.10.30.1-0.20.10.0-0.7
Time in novel zone, NPP test0.10.20.80.50.00.30.2-0.0-0.1-0.1-0.9
Total zone transitions, NPP test1.11.63.0-1.50.1-0.3-0.3-1.71.61.61.4
Total locomotion distance, NPP test1.01.43.2-1.1-0.7-0.6-0.7-1.81.71.60.6
Locomotion velocity, NPP test1.72.45.1-1.6-0.8-0.7-0.8-2.32.12.01.1
Intraocular pressure0.81.32.2-1.5-1.5-1.5-1.2-0.50.80.90.7
Delta distance traveled before/after self-admin1.71.83.61.8-0.40.10.21.7-1.8-1.9-1.3
Delta ambulatory time before/after self-admin0.91.63.41.8-0.00.50.41.3-1.7-1.7-1.1
Parametrial fat weight0.51.12.71.1-0.9-1.7-1.21.2-0.9-0.80.1
Pavlov. Cond. lever latency2.22.75.21.0-1.8-1.9-1.92.3-1.7-1.6-0.0
Pavlov. Cond. magazine entry latency1.31.72.5-1.31.51.41.5-1.61.01.00.6
Pavlov. Cond. change in total contacts0.70.82.20.41.51.21.3-0.80.30.3-0.3
Pavlov. Cond. index score2.32.94.9-1.22.01.92.0-2.21.61.50.4
Pavlov. Cond. latency score2.43.05.3-0.92.12.02.1-2.31.61.50.5
Pavlov. Cond. lever contacts2.12.64.4-0.62.12.02.0-2.01.41.3-0.1
Pavlov. Cond. magazine entry number1.01.22.31.5-1.3-1.1-1.11.2-0.9-0.9-0.6
Pavlov. Cond. intertrial magazine entries1.62.05.8-1.0-2.4-2.1-2.10.30.20.20.3
Pavlov. Cond. lever-magazine prob. diff.2.22.84.9-1.41.81.81.9-2.21.71.60.4
Pavlov. Cond. response bias1.62.02.9-1.51.61.61.6-1.71.31.30.3
Pavlov. Cond. lever latency0.30.51.20.80.61.11.1-0.3-0.0-0.10.1
Pavlov. Cond. magazine entry latency0.10.20.50.40.70.40.3-0.20.00.1-0.7
Pavlov. Cond. change in total contacts0.10.20.50.30.1-0.4-0.40.6-0.6-0.5-0.7
Pavlov. Cond. index score0.00.10.2-0.30.2-0.2-0.20.2-0.1-0.0-0.5
Pavlov. Cond. latency score0.10.10.4-0.00.2-0.3-0.40.4-0.3-0.2-0.6
Pavlov. Cond. lever contacts0.20.31.0-0.6-0.6-1.0-1.00.3-0.1-0.0-0.0
Pavlov. Cond. magazine entry number0.10.10.3-0.4-0.50.10.20.0-0.0-0.10.5
Pavlov. Cond. intertrial magazine entries0.51.12.2-1.50.90.91.1-1.00.80.71.4
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.30.2-0.3-0.30.2-0.1-0.0-0.5
Pavlov. Cond. response bias0.10.10.4-0.6-0.0-0.5-0.4-0.20.30.40.0
Time in closed arm before self-admin0.10.30.9-0.10.20.90.60.3-0.5-0.6-0.3
Time in closed arm after self-admin0.40.41.61.3-0.10.2-0.00.3-0.8-0.8-0.4
Time in open arm before self-admin0.20.20.5-0.7-0.20.20.2-0.70.50.70.0
Time in open arm after self-admin0.30.30.9-0.8-0.3-0.30.00.10.70.9-0.2
Bone: periosteal estimation2.04.76.32.42.42.42.51.9-2.2-2.2-0.9
Bone: periosteal perimeter0.91.84.21.21.82.02.10.4-0.7-0.7-0.3
Bone: post-yield work0.61.13.2-0.21.31.81.80.4-0.3-0.3-0.2
Progressive ratio test 1 active lever presses0.10.20.60.2-0.3-0.60.0-0.10.60.6-0.7
Progressive ratio test 1 breakpoint0.10.20.60.3-0.3-0.50.1-0.00.50.4-0.8
Progressive ratio test 1 inactive lever presses0.20.61.80.0-1.0-1.3-1.2-0.10.40.30.3
Progressive ratio test 2 active lever presses0.81.11.9-0.8-1.1-1.4-0.8-1.01.31.30.7
Progressive ratio test 2 breakpoint1.01.22.0-0.8-1.2-1.4-1.0-1.01.31.30.7
Progressive ratio test 2 inactive lever presses0.10.41.00.80.1-0.30.4-0.40.70.6-1.0
Incentive Sensitization - Responses0.30.92.0-1.0-0.8-0.7-0.6-1.10.80.81.4
Incentive Sensitization - Breakpoint0.51.22.4-1.1-1.1-0.9-0.8-1.21.01.01.5
Sum of active levers in priming session hrs 5-60.30.31.2-0.40.2-0.00.60.2-0.6-0.5-1.1
Progressive ratio1.13.37.72.80.6-0.4-0.72.5-2.4-2.3-0.3
Food seeking constrained by brief footshock0.10.10.3-0.3-0.3-0.2-0.60.30.10.1-0.4
Seeking ratio, punishment vs. effort0.92.14.9-2.2-0.30.60.6-1.82.01.9-0.0
Retroperitoneal fat weight0.10.31.00.9-0.0-1.0-0.80.1-0.1-0.0-0.3
Reaction time number correct0.41.42.20.6-1.5-1.2-1.31.3-1.1-1.1-1.2
Reaction time mean minus median0.31.72.4-1.21.20.81.1-1.51.61.61.2
Reaction time mean minus median AUC0.21.42.6-1.20.80.60.8-1.51.61.60.4
Reaction time num false alarms0.30.51.30.71.11.11.0-0.5-0.00.10.4
Reaction time num false alarms AUC0.40.92.11.11.51.31.3-0.3-0.3-0.20.4
Reaction time trials correct on left0.41.42.20.6-1.5-1.2-1.31.3-1.1-1.1-1.2
Reaction time trials on left0.41.41.90.6-1.4-1.1-1.21.3-1.1-1.1-1.3
Reaction time mean1.02.24.2-1.42.11.41.6-1.51.41.60.2
Reaction time mean AUC0.82.03.7-1.41.91.31.5-1.51.41.60.2
Median of all reaction times1.01.54.0-1.12.01.31.4-1.11.01.2-0.2
Reaction time omissions0.91.43.3-0.91.81.11.5-1.20.91.00.8
Reaction time false alarm rate1.41.95.30.62.32.01.9-1.00.30.40.8
Reaction time premature initiation rate0.71.02.91.70.30.30.21.1-1.3-1.3-0.9
Reaction time premature initiations0.72.24.02.0-0.6-0.3-0.51.9-2.0-1.9-1.4
Std. dev. reaction times0.62.04.0-0.92.01.61.9-1.21.21.30.4
Reaction time trials completed0.41.41.90.6-1.4-1.1-1.21.3-1.1-1.1-1.3
Reaction time trials AUC0.41.31.90.5-1.4-1.1-1.21.3-1.1-1.0-1.2
Run reversals in cocaine runway, females0.10.20.7-0.2-0.3-0.8-0.50.20.00.2-0.4
Run reversals in cocaine runway, males0.20.30.50.50.70.70.6-0.50.40.4-0.1
Latency to leave start box in cocaine runway0.50.61.70.90.31.30.7-1.20.50.40.1
Latency to leave start box in cocaine runway, F0.30.41.40.20.11.00.3-1.20.60.50.4
Latency to leave start box in cocaine runway, M0.40.42.11.50.30.70.6-0.2-0.2-0.3-0.3
Std. dev. time between licks in bursts1.73.28.50.42.82.92.9-0.1-0.6-0.7-0.4
Total sessions with >9 infusions0.30.30.90.4-0.1-0.9-0.10.10.60.6-0.9
Short access day 1 total inactive lever presses0.61.13.51.51.01.00.90.2-0.3-0.3-1.9
Short access day 10 total inactive lever presses0.11.03.0-0.5-0.50.3-0.2-1.21.21.21.7
Short access day 1 total infusions0.30.52.00.01.0-0.30.1-0.10.80.8-1.4
Short access day 10 total infusions0.30.51.1-0.1-0.9-1.0-0.6-0.41.00.9-0.2
Short access total infusions0.40.51.60.4-0.1-0.8-0.3-0.11.00.9-1.3
Short access day 1 locomotion1.11.84.8-1.40.2-0.40.2-1.52.21.91.3
Short access day 10 total locomotion0.41.73.20.81.81.51.71.4-1.2-1.3-0.3
Short access total locomotion0.30.52.00.01.40.61.10.20.40.3-0.3
One hour access (0.3 mA shock)2.12.55.2-1.4-0.7-0.9-0.4-2.31.91.82.1
Compulsive drug intake2.13.17.3-1.41.11.81.4-2.11.51.62.7
One hour access (shock baseline)0.51.24.5-0.1-1.6-2.1-1.5-0.20.50.4-0.4
Social response proportion1.41.82.90.61.71.41.11.1-1.3-1.4-1.7
Social responses1.21.62.31.11.51.21.01.2-1.4-1.4-1.2
Social time1.62.56.50.42.62.02.2-1.10.70.71.5
Soleus weight2.67.519.91.54.04.54.30.2-1.0-1.0-1.1
Bone: stiffness0.30.61.51.0-1.2-0.8-0.60.6-0.3-0.40.7
Tibialis anterior weight0.30.92.20.3-1.5-1.4-1.30.5-0.3-0.40.9
Time to tail flick, vehicle, before self-admin1.31.65.7-1.2-0.3-0.5-0.4-1.51.21.22.4
Time to tail flick, vehicle, after self-admin0.30.61.1-0.60.90.40.8-1.01.01.00.3
Time to tail flick, test, before self-admin0.50.51.9-0.5-0.7-0.4-0.6-0.60.60.51.4
Time to tail flick, test, after self-admin1.21.32.5-1.6-1.3-0.8-1.0-1.40.60.71.2
Delta time to tail flick, vehicle, before/after SA0.50.52.4-0.0-0.4-0.4-0.4-0.50.70.8-1.5
Delta time to tail flick, test, before/after SA0.40.51.0-0.9-1.0-0.9-0.8-0.60.20.20.2
Tibia length2.46.78.22.92.72.72.82.5-2.6-2.6-1.8
Ambulatory time before self-admin0.10.20.7-0.30.30.30.1-0.10.50.60.8
Ambulatory time after self-admin0.71.12.11.40.40.60.41.4-1.4-1.4-0.2
Bone: tissue strength1.21.34.42.1-0.1-0.1-0.30.9-0.8-0.9-1.8
Total heroin consumption0.10.10.20.1-0.00.40.5-0.1-0.3-0.20.1
Bone: trabecular number2.14.05.3-1.9-2.0-2.3-2.0-1.92.02.11.5
Bone: trabecular spacing3.04.57.02.61.62.11.81.9-2.1-2.2-2.4
Bone: trabecular thickness1.92.63.6-1.8-1.9-1.9-1.6-1.21.41.31.6
Bone: trabecular tissue density0.50.83.01.70.50.50.30.3-0.8-0.8-1.1
Water consumed over 24 hours0.10.20.70.80.00.80.70.1-0.1-0.1-0.2
Number of responses in last shaping day1.92.44.91.71.91.62.20.9-0.9-0.8-1.7