Hub : Genes

Apoc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Apoc2 0.49 0.16 0.0e+00 0.31 0.32 0.32 0.32 4.6e-35 4.6e-36 5.8e-37 2.0e-36

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.00.00.0-0.2
Area under the delay curve1.82.72.71.6
BMI with tail0.82.82.8-1.7
BMI without tail0.42.32.3-1.5
Body weight1.25.35.3-2.3
Weight adjusted by age0.00.00.0-0.2
Bone surface0.40.70.7-0.8
Bone volume0.20.40.4-0.7
Breakpoint value in progressive ratio session1.42.62.61.6
Number of licking bursts1.23.73.7-1.9
Context. condit. distance diff. score0.00.00.0-0.2
Locomotion velocity, session 10.30.30.30.6
Locomotion distance, session 10.00.10.1-0.3
Locomotion velocity, session 21.01.21.2-1.1
Locomotion distance, session 20.50.70.7-0.8
Locomotion velocity, session 30.10.10.1-0.3
Locomotion distance, session 30.70.80.80.9
Stereotopy head waving bouts, day 30.60.70.7-0.9
Stereotopy head waving duration, day 30.91.11.1-1.1
Locomotion velocity, session 70.00.00.00.1
Locomotion distance, session 70.00.00.0-0.0
Stereotopy head waving bouts, day 71.21.41.4-1.2
Stereotopy head waving duration, day 70.81.01.0-1.0
Locomotion velocity, session 80.00.10.10.2
Locomotion distance, session 80.00.00.0-0.0
Degree of sensitization distance0.30.30.3-0.6
Degree of sensitization stereotypy1.31.51.5-1.2
Conditioned locomotion0.00.00.00.0
Cocaine response after cond. corrected0.50.80.8-0.9
Cocaine response after cond. not corrected1.42.12.1-1.4
Cocaine response before conditioning1.51.81.8-1.4
Saline control response2.33.13.1-1.8
Bone: connectivity density0.00.00.0-0.1
Bone: cortical apparent density0.20.20.20.5
Bone: cortical area1.21.91.9-1.4
Bone: cortical porosity0.50.60.60.7
Bone: cortical porosity0.10.10.10.3
Bone: cortical thickness0.50.90.9-0.9
Bone: cortical thickness1.01.31.3-1.1
Bone: cortical tissue density0.20.30.30.6
Condit. Reinf. active minus inactive responses0.40.40.4-0.6
Condit. Reinf. active-inactive response ratio0.50.50.5-0.7
Condit. Reinf. active responses0.20.30.3-0.5
Condit. Reinf. inactive responses0.00.00.00.2
Incentive salience index mean0.30.40.4-0.6
Condit. Reinf. lever presses0.20.20.2-0.5
Condit. Reinf. active minus inactive responses0.10.20.2-0.4
Condit. Reinf. active-inactive response ratio0.61.01.0-1.0
Condit. Reinf. active responses0.10.10.10.3
Condit. Reinf. inactive responses1.01.41.41.2
Condit. Reinf. lever presses0.20.30.3-0.5
Condit. Reinf. lever reinforcers received0.10.10.10.3
Conditioned reinforcement - actives1.14.54.5-2.1
Conditioned reinforcement - inactives0.30.70.7-0.9
Conditioned locomotion3.14.64.6-2.1
Patch foraging indifference point 0 sec0.00.10.1-0.4
Patch foraging indifference point AUC1.63.93.9-2.0
Delay disc. indifference point, 0s delay1.41.61.61.3
Delay disc. indifference point, 16s delay1.92.72.71.6
Delay disc. indifference point, 2s delay4.55.15.12.2
Delay disc. indifference point, 24s delay0.20.30.3-0.6
Delay disc. indifference point, 4s delay0.00.00.00.1
Delay disc. indifference point, 8s delay1.83.03.01.7
Indifference point function ln k0.61.71.71.3
Indifference point function log k0.61.71.71.3
Patch foraging total patch changes 0 sec0.10.30.3-0.5
Patch foraging total patch changes 12 sec1.11.51.5-1.2
Patch foraging total patch changes 18 sec0.61.31.3-1.2
Patch foraging total patch changes 24 sec0.10.20.2-0.4
Patch foraging total patch changes 6 sec1.52.62.6-1.6
Patch foraging time to switch 0 sec1.65.95.92.4
Patch foraging water rate 0 sec1.76.46.4-2.5
Patch foraging water rate 12 sec0.10.30.3-0.6
Patch foraging water rate 18 sec0.00.00.0-0.0
Patch foraging water rate 24 sec0.40.50.5-0.7
Patch foraging water rate 6 sec0.71.01.0-1.0
Seeking ratio, delayed vs. immediate footshock1.31.91.91.4
Distance traveled before self-admin0.00.00.0-0.2
Distance traveled after self-admin0.20.30.30.6
Extensor digitorum longus weight1.55.85.8-2.4
Bone: elastic displacement1.31.61.61.3
Bone: elastic work0.00.00.0-0.0
Bone: endosteal estimation0.00.00.00.1
Bone: endosteal perimeter0.00.00.00.2
Epididymis fat weight0.21.31.31.1
Delta time in closed arm before/after self-admin0.30.30.30.5
Delta time in open arm before/after self-admin0.00.00.00.2
Diff in mean of infusions in LGA sessions1.01.81.81.3
Delay discount exponential model param1.41.91.9-1.4
Extinction: sum of active levers before priming0.00.10.10.2
Active lever presses in extinction session 60.10.10.1-0.3
Bone: final force0.10.20.2-0.5
Bone: final moment0.30.50.5-0.7
Food consumed during 24 hour testing period3.06.06.02.4
Glucose0.00.10.10.3
Heart weight2.64.14.1-2.0
Delay discount hyperbolic model param1.41.81.8-1.4
Intermittent access intake day 1-15 change0.00.20.2-0.5
Intermittent access intake escalation0.10.40.4-0.6
Intermittent access intake escalation 20.10.10.1-0.3
Intermitt. access day 1 inactive lever presses0.00.00.00.1
Intermitt. access day 15 inactive lever presses0.00.20.20.4
Intermitt. access escalation Index0.10.20.20.5
Intermittent access day 1 total infusions0.61.91.9-1.4
Intermittent access day 15 total infusions0.51.11.1-1.1
Intermittent access terminal intake (last 3 days)0.91.61.6-1.3
Intermittent access total infusions2.93.43.4-1.9
Intermittent access day 1 locomotion0.50.80.8-0.9
Intermittent access day 15 total locomotion0.10.40.4-0.6
Intermittent access total locomotion2.63.13.1-1.8
Intermittent access standard deviation0.00.10.10.2
Left kidney weight3.628.928.9-5.4
Right kidney weight4.028.228.2-5.3
Cocaine induced anxiety0.20.40.40.7
Post-drug Anxiety0.20.20.20.4
Baseline Anxiety0.00.00.0-0.0
Tail length0.21.01.0-1.0
Length with tail0.31.21.2-1.1
Length without tail0.21.31.3-1.1
Times rat made contact with spout0.10.10.1-0.3
Lifetime Intake2.73.33.3-1.8
Liver weight, left2.13.73.7-1.9
Liver weight, right1.42.52.5-1.6
Locomotor activity1.92.92.9-1.7
Locomotor testing distance0.92.12.1-1.4
Locomotor testing rearing2.59.09.0-3.0
Locomotion in novel chamber0.10.10.10.3
Locomotion in novel chamber post-restriction0.61.71.71.3
Fecal boli incidents, locomotor time 10.00.10.1-0.3
Change in fecal boli incidents, locomotor task0.70.70.70.8
Time >=10cm from walls, locomotor time 10.10.10.10.3
Bouts of movement, locomotor time 12.32.92.91.7
Total resting periods, locomotor time 13.33.83.82.0
Rest time, locomotor task time 10.20.30.30.5
Distance moved, locomotor task time 10.51.51.5-1.2
Vertical activity count, locomotor time 10.00.00.0-0.2
Time >=10cm from walls, locomotor time 20.00.00.00.2
Bouts of movement, locomotor time 22.27.47.42.7
Total resting periods, locomotor time 21.76.76.72.6
Rest time, locomotor task time 20.10.20.20.4
Distance moved, locomotor task time 22.02.72.7-1.6
Vertical activity count, locomotor time 20.00.10.1-0.3
Light reinforcement 10.10.30.3-0.5
Light reinforcement 20.10.20.2-0.4
Bone: marrow area0.00.00.00.0
Bone: maximum diameter1.93.93.9-2.0
Bone: maximum force0.10.20.2-0.4
Bone: maximum moment0.20.30.3-0.6
Mean time between licks in bursts0.00.00.0-0.0
Mean num. licks in bursts1.02.72.71.7
Cd content in liver0.00.00.0-0.1
Co content in liver1.41.71.71.3
Cu content in liver0.10.10.1-0.3
Fe content in liver2.83.53.5-1.9
K content in liver0.00.00.0-0.1
Mg content in liver0.60.60.6-0.8
Mn content in liver1.71.91.9-1.4
Na content in liver0.00.00.00.0
Rb content in liver0.20.20.2-0.5
Se content in liver3.44.04.0-2.0
Sr content in liver0.00.00.0-0.1
Zn content in liver0.60.70.7-0.8
Bone: minimum diameter0.10.20.2-0.4
Time in familiar zone, hab. session 10.10.10.1-0.3
Time in novel zone, hab. session 10.70.80.8-0.9
Total zone transitions, hab. session 10.10.10.1-0.3
Total locomotion distance, hab. session 11.01.41.41.2
Locomotion velocity, hab. session 12.23.13.11.8
Time in familiar zone, hab. session 20.10.10.1-0.3
Time in novel zone, hab. session 20.00.00.00.1
Total zone transitions, hab. session 20.50.70.7-0.8
Total locomotion distance, hab. session 20.81.11.11.0
Locomotion velocity, hab. session 20.50.70.70.9
Novel to familiar place preference ratio1.11.51.5-1.2
Novelty place preference1.11.41.4-1.2
Time in novel zone, NPP test1.31.61.6-1.3
Total zone transitions, NPP test0.00.00.0-0.1
Total locomotion distance, NPP test0.00.00.0-0.1
Locomotion velocity, NPP test0.00.00.0-0.0
Intraocular pressure0.00.00.00.1
Delta distance traveled before/after self-admin2.12.32.31.5
Delta ambulatory time before/after self-admin0.30.50.50.7
Parametrial fat weight0.10.20.2-0.4
Pavlov. Cond. lever latency0.70.80.80.9
Pavlov. Cond. magazine entry latency0.00.10.1-0.2
Pavlov. Cond. change in total contacts0.20.30.30.5
Pavlov. Cond. index score0.30.40.4-0.6
Pavlov. Cond. latency score0.10.10.1-0.3
Pavlov. Cond. lever contacts0.40.40.4-0.7
Pavlov. Cond. magazine entry number0.00.00.00.2
Pavlov. Cond. intertrial magazine entries0.30.40.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.50.60.6-0.8
Pavlov. Cond. response bias1.01.21.2-1.1
Pavlov. Cond. lever latency0.10.10.10.3
Pavlov. Cond. magazine entry latency0.10.20.2-0.5
Pavlov. Cond. change in total contacts0.00.00.00.1
Pavlov. Cond. index score0.00.00.0-0.2
Pavlov. Cond. latency score0.00.00.0-0.1
Pavlov. Cond. lever contacts0.20.30.3-0.5
Pavlov. Cond. magazine entry number0.10.10.1-0.3
Pavlov. Cond. intertrial magazine entries0.00.10.10.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.4
Pavlov. Cond. response bias0.00.10.1-0.3
Time in closed arm before self-admin1.01.81.8-1.3
Time in closed arm after self-admin0.70.80.80.9
Time in open arm before self-admin1.21.51.51.2
Time in open arm after self-admin0.10.20.20.4
Bone: periosteal estimation0.20.50.5-0.7
Bone: periosteal perimeter0.10.20.2-0.5
Bone: post-yield work0.50.90.90.9
Progressive ratio test 1 active lever presses2.13.73.7-1.9
Progressive ratio test 1 breakpoint2.03.53.5-1.9
Progressive ratio test 1 inactive lever presses0.61.51.5-1.2
Progressive ratio test 2 active lever presses1.62.32.3-1.5
Progressive ratio test 2 breakpoint2.02.52.5-1.6
Progressive ratio test 2 inactive lever presses0.00.00.0-0.2
Incentive Sensitization - Responses0.41.21.2-1.1
Incentive Sensitization - Breakpoint0.41.01.0-1.0
Sum of active levers in priming session hrs 5-60.20.20.20.4
Progressive ratio0.72.12.11.4
Food seeking constrained by brief footshock3.03.83.82.0
Seeking ratio, punishment vs. effort0.10.20.20.4
Retroperitoneal fat weight0.00.00.00.0
Reaction time number correct2.38.28.2-2.9
Reaction time mean minus median0.00.00.0-0.2
Reaction time mean minus median AUC0.10.80.8-0.9
Reaction time num false alarms3.76.26.2-2.5
Reaction time num false alarms AUC2.35.25.2-2.3
Reaction time trials correct on left2.38.28.2-2.9
Reaction time trials on left2.48.38.3-2.9
Reaction time mean0.30.60.60.8
Reaction time mean AUC0.20.50.50.7
Median of all reaction times0.71.11.11.1
Reaction time omissions0.20.40.4-0.6
Reaction time false alarm rate0.10.10.1-0.4
Reaction time premature initiation rate0.20.20.20.5
Reaction time premature initiations0.30.90.9-0.9
Std. dev. reaction times0.00.00.00.0
Reaction time trials completed2.48.38.3-2.9
Reaction time trials AUC2.910.210.2-3.2
Run reversals in cocaine runway, females0.20.20.20.4
Run reversals in cocaine runway, males0.40.40.4-0.7
Latency to leave start box in cocaine runway0.00.00.0-0.1
Latency to leave start box in cocaine runway, F0.70.90.9-1.0
Latency to leave start box in cocaine runway, M0.50.40.40.7
Std. dev. time between licks in bursts0.00.00.0-0.2
Total sessions with >9 infusions4.45.55.5-2.3
Short access day 1 total inactive lever presses0.20.40.4-0.7
Short access day 10 total inactive lever presses0.31.81.81.4
Short access day 1 total infusions1.32.72.7-1.6
Short access day 10 total infusions3.25.35.3-2.3
Short access total infusions2.23.23.2-1.8
Short access day 1 locomotion2.74.54.5-2.1
Short access day 10 total locomotion0.10.50.5-0.7
Short access total locomotion1.82.72.7-1.7
One hour access (0.3 mA shock)0.00.00.0-0.0
Compulsive drug intake0.10.20.2-0.4
One hour access (shock baseline)0.51.21.2-1.1
Social response proportion1.72.22.2-1.5
Social responses1.52.02.0-1.4
Social time2.03.23.21.8
Soleus weight0.00.00.0-0.1
Bone: stiffness0.50.90.9-0.9
Tibialis anterior weight2.89.69.6-3.1
Time to tail flick, vehicle, before self-admin3.34.14.1-2.0
Time to tail flick, vehicle, after self-admin0.00.00.0-0.1
Time to tail flick, test, before self-admin0.10.10.10.3
Time to tail flick, test, after self-admin0.20.20.20.5
Delta time to tail flick, vehicle, before/after SA0.10.10.10.4
Delta time to tail flick, test, before/after SA0.40.40.4-0.7
Tibia length0.20.70.7-0.8
Ambulatory time before self-admin0.00.00.00.1
Ambulatory time after self-admin0.40.60.60.8
Bone: tissue strength0.30.30.30.5
Total heroin consumption0.00.00.0-0.2
Bone: trabecular number0.00.00.00.1
Bone: trabecular spacing0.00.00.0-0.1
Bone: trabecular thickness1.41.91.9-1.4
Bone: trabecular tissue density0.30.60.6-0.8
Water consumed over 24 hours0.00.00.0-0.2
Number of responses in last shaping day3.44.54.5-2.1