Hub : Genes

Apc2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA alternative TSS NM_001106769.2 0.03 0.03 7.3e-03 0.01 0.01 0.01 0 6.0e-02 4.9e-02 6.7e-02 1.1e-01
2 pVTA alternative TSS XM_039078651.2 0.03 0.03 3.2e-03 0.02 0.02 0.01 0.02 1.6e-02 9.7e-03 2.0e-02 1.7e-02
3 Adipose isoform ratio XM_017594717.3 0.06 0.04 2.8e-06 0.04 0.04 0.02 0.04 7.9e-05 2.4e-05 3.0e-03 3.3e-05
4 Adipose intron excision ratio chr7_10059363_10059897 0.14 0.08 4.4e-16 0.12 0.13 0.13 0.13 1.4e-13 2.1e-14 5.0e-14 2.7e-14
5 Adipose alternative TSS XM_039078652.2 0.06 0.04 6.2e-07 0.03 0.04 0.04 0.04 9.6e-05 8.5e-06 1.5e-05 2.1e-05
6 Adipose alternative TSS XM_039078652.2 0.06 0.04 7.1e-07 0.03 0.04 0.04 0.04 1.3e-04 1.1e-05 1.5e-05 2.6e-05
7 Adipose mRNA stability Apc2 0.04 0.03 2.8e-05 0.02 0.02 0.02 0.02 4.2e-03 1.1e-03 5.8e-03 2.3e-03
8 Adipose alternative TSS XM_063263171.1 0.02 0.02 6.7e-03 0.01 0.01 0.01 0.01 2.6e-02 1.4e-02 6.1e-02 3.4e-02
9 pVTA alternative TSS XM_063263171.1 0.03 0.02 6.9e-03 0.02 0.02 0.01 0.01 1.6e-02 6.9e-03 2.1e-02 1.9e-02
10 pVTA alternative TSS XM_063263171.1 0.02 0.02 9.0e-03 0.01 0.02 0 0.01 3.4e-02 1.3e-02 1.5e-01 4.2e-02
11 pVTA gene expression Apc2 0.21 0.11 0.0e+00 0.24 0.24 0.24 0.24 3.6e-19 1.0e-19 6.2e-19 1.1e-19
12 Adipose gene expression Apc2 0.31 0.15 0.0e+00 0.23 0.26 0.26 0.26 6.8e-25 1.0e-28 8.5e-29 3.9e-29
13 OFC gene expression Apc2 0.14 0.1 1.4e-03 0.12 0.12 0.11 0.11 1.2e-03 1.0e-03 1.4e-03 1.4e-03
14 Liver gene expression Apc2 0.16 0.1 2.2e-14 0.12 0.1 0.09 0.11 3.6e-13 9.0e-11 1.4e-10 4.7e-12
15 Eye isoform ratio XM_063263172.1 0.2 0.14 5.0e-03 0.18 0.16 0.14 0.16 9.0e-04 2.2e-03 3.5e-03 2.3e-03
16 IL gene expression Apc2 0.26 0.16 9.2e-05 0.12 0.09 0.1 0.1 9.1e-04 3.3e-03 2.5e-03 1.9e-03
17 IC gene expression Apc2 0.33 0.15 2.0e-13 0.21 0.22 0.21 0.22 3.5e-09 1.4e-09 2.5e-09 8.9e-10
18 PL gene expression Apc2 0.1 0.06 2.9e-12 0.12 0.11 0.1 0.11 3.2e-13 4.2e-12 4.9e-11 2.1e-12
19 BLA gene expression Apc2 0.1 0.06 4.6e-06 0.11 0.1 0.09 0.09 2.7e-06 4.8e-06 1.1e-05 1.1e-05
20 Brain gene expression Apc2 0.21 0.1 0.0e+00 0.22 0.23 0.23 0.23 1.6e-20 1.4e-21 2.9e-21 3.5e-21
21 Adipose alternative TSS XM_063263171.1 0.02 0.02 2.1e-03 0.02 0.01 0.01 0.01 1.5e-03 1.7e-02 6.3e-02 2.5e-02
22 NAcc gene expression Apc2 0.12 0.07 0.0e+00 0.14 0.14 0.14 0.14 4.2e-21 1.7e-20 3.6e-20 2.7e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22
Bone: apparent density0.20.30.90.6-0.3-0.3-0.2-0.2-0.1-0.1-0.2-0.2-0.20.3-0.20.3-0.9-0.70.70.70.90.70.9-0.70.7
Area under the delay curve2.22.62.9-1.61.61.61.61.61.61.6-1.7-1.7-1.71.71.61.71.4-1.71.71.61.51.51.6-1.71.7
BMI with tail6.723.326.4-4.94.94.94.94.94.94.9-4.9-4.9-4.94.85.14.85.1-4.64.64.74.64.84.5-4.64.6
BMI without tail2.16.47.7-2.82.72.72.72.72.72.7-2.6-2.6-2.62.52.72.52.8-2.32.32.32.22.42.1-2.22.2
Body weight1.04.34.9-2.12.12.12.12.12.12.1-2.1-2.1-2.12.12.22.12.2-2.02.02.02.02.11.9-1.91.9
Weight adjusted by age0.30.51.1-1.00.90.90.90.90.90.9-0.8-0.8-0.70.70.60.70.8-0.30.30.60.60.50.4-0.40.4
Bone surface0.40.73.81.5-1.2-1.1-1.0-1.0-1.0-0.90.50.50.5-0.3-1.0-0.3-2.0-0.30.30.20.30.30.6-0.30.3
Bone volume0.40.63.91.4-1.1-1.0-0.9-0.9-0.8-0.80.40.40.3-0.2-1.0-0.2-2.0-0.30.30.30.60.30.7-0.30.3
Breakpoint value in progressive ratio session3.74.45.01.9-2.0-2.1-2.1-2.1-2.1-2.12.22.22.2-2.2-2.0-2.2-1.62.2-2.2-2.2-2.2-2.2-2.22.1-2.1
Number of licking bursts0.10.10.4-0.70.50.50.50.40.40.4-0.2-0.2-0.20.20.30.10.60.2-0.2-0.1-0.0-0.2-0.20.2-0.2
Context. condit. distance diff. score0.30.40.5-0.60.60.60.60.60.60.6-0.6-0.6-0.60.60.70.60.7-0.60.60.70.20.70.5-0.60.6
Locomotion velocity, session 10.50.61.41.2-1.0-1.0-1.0-1.0-1.0-0.90.80.80.7-0.7-0.9-0.7-1.10.4-0.4-0.4-0.4-0.4-0.30.4-0.4
Locomotion distance, session 10.40.41.81.3-1.1-1.0-0.9-0.9-0.9-0.90.60.60.5-0.4-0.5-0.4-0.9-0.10.10.1-0.10.10.3-0.10.1
Locomotion velocity, session 24.35.18.73.0-2.8-2.7-2.7-2.7-2.6-2.62.32.32.3-2.2-2.2-2.2-2.61.5-1.5-1.7-2.0-1.7-1.51.5-1.5
Locomotion distance, session 21.92.75.82.4-2.2-2.1-2.1-2.0-2.0-2.01.71.71.6-1.5-1.7-1.5-2.11.0-1.0-1.1-0.9-1.1-0.71.0-1.0
Locomotion velocity, session 36.47.38.52.6-2.7-2.7-2.7-2.7-2.7-2.72.82.82.8-2.8-2.7-2.8-2.52.6-2.6-2.8-2.9-2.7-2.82.6-2.6
Locomotion distance, session 30.00.00.0-0.20.10.10.10.10.10.1-0.0-0.0-0.00.00.0-0.00.10.0-0.0-0.1-0.1-0.0-0.10.0-0.0
Stereotopy head waving bouts, day 35.56.47.82.8-2.8-2.8-2.7-2.7-2.7-2.72.62.62.6-2.6-2.4-2.6-2.52.2-2.2-2.4-2.5-2.5-2.22.2-2.2
Stereotopy head waving duration, day 36.67.88.72.9-2.9-2.9-2.9-2.9-2.9-2.92.92.92.9-2.9-2.7-2.9-2.72.5-2.5-2.8-2.8-2.9-2.62.5-2.5
Locomotion velocity, session 70.40.51.00.5-0.6-0.6-0.6-0.6-0.6-0.60.60.60.6-0.6-0.9-0.6-1.00.8-0.8-0.6-0.9-0.6-0.70.8-0.8
Locomotion distance, session 70.20.30.8-0.90.80.80.70.70.70.7-0.6-0.6-0.50.50.50.50.7-0.10.10.30.20.30.1-0.10.1
Stereotopy head waving bouts, day 70.10.10.20.4-0.3-0.3-0.2-0.2-0.2-0.20.00.10.00.0-0.10.0-0.4-0.40.40.20.20.10.4-0.40.4
Stereotopy head waving duration, day 70.40.41.21.1-0.9-0.9-0.9-0.9-0.8-0.80.60.70.6-0.6-0.7-0.5-1.10.2-0.2-0.4-0.2-0.4-0.10.2-0.2
Locomotion velocity, session 80.70.92.21.5-1.3-1.3-1.2-1.2-1.2-1.10.90.90.9-0.8-1.0-0.8-1.40.3-0.3-0.4-0.5-0.4-0.20.3-0.3
Locomotion distance, session 80.20.30.80.9-0.8-0.8-0.7-0.7-0.7-0.70.60.60.5-0.5-0.4-0.5-0.60.2-0.2-0.2-0.5-0.2-0.20.2-0.2
Degree of sensitization distance0.50.50.6-0.70.70.70.70.70.70.7-0.7-0.7-0.70.70.70.70.6-0.70.70.80.50.80.7-0.70.7
Degree of sensitization stereotypy1.71.82.5-1.01.11.21.21.21.21.2-1.3-1.3-1.41.41.21.40.9-1.61.61.51.61.41.6-1.61.6
Conditioned locomotion1.41.63.0-1.71.61.61.51.51.51.5-1.3-1.3-1.31.21.41.21.7-0.90.90.91.00.90.8-0.90.9
Cocaine response after cond. corrected5.66.810.2-3.23.03.03.03.02.92.9-2.7-2.7-2.72.62.72.63.0-2.12.12.22.02.11.9-2.12.1
Cocaine response after cond. not corrected6.07.010.6-3.33.13.13.03.03.03.0-2.7-2.7-2.72.62.82.63.0-2.22.22.22.02.21.9-2.22.2
Cocaine response before conditioning0.50.71.00.9-0.9-0.9-0.9-0.9-0.9-0.90.80.80.8-0.8-0.9-0.8-1.00.7-0.7-0.7-0.8-0.7-0.70.7-0.7
Saline control response0.10.20.5-0.60.60.50.50.50.50.5-0.4-0.4-0.40.40.50.40.7-0.20.20.30.30.20.2-0.20.2
Bone: connectivity density0.30.41.10.10.10.20.20.30.30.3-0.5-0.5-0.60.60.30.6-0.2-1.01.00.91.00.91.1-1.01.0
Bone: cortical apparent density0.91.31.7-1.11.11.11.11.11.11.1-1.2-1.2-1.21.21.01.20.9-1.11.11.11.31.11.2-1.11.1
Bone: cortical area0.40.71.2-0.40.50.60.60.60.60.7-0.8-0.8-0.80.90.40.9-0.0-1.01.01.01.11.01.1-1.01.0
Bone: cortical porosity0.10.20.60.6-0.5-0.5-0.5-0.5-0.5-0.50.30.40.3-0.3-0.5-0.3-0.80.2-0.2-0.1-0.0-0.2-0.00.2-0.2
Bone: cortical porosity0.10.10.50.5-0.4-0.4-0.3-0.3-0.3-0.30.10.10.1-0.0-0.30.0-0.7-0.20.20.30.40.20.4-0.20.2
Bone: cortical thickness1.11.82.6-1.01.11.21.21.21.21.2-1.3-1.3-1.41.41.11.40.7-1.51.51.51.61.51.6-1.51.5
Bone: cortical thickness0.10.10.2-0.40.30.30.20.20.20.2-0.0-0.00.0-0.1-0.0-0.10.30.4-0.4-0.3-0.2-0.4-0.40.4-0.4
Bone: cortical tissue density0.60.81.2-0.90.90.90.90.90.90.9-0.9-0.9-0.90.90.80.90.7-0.90.90.91.10.91.0-0.90.9
Condit. Reinf. active minus inactive responses4.75.26.32.3-2.3-2.4-2.4-2.4-2.4-2.42.42.42.4-2.4-2.1-2.4-2.02.1-2.1-2.3-2.5-2.2-2.22.1-2.1
Condit. Reinf. active-inactive response ratio2.22.43.41.2-1.3-1.4-1.4-1.4-1.4-1.41.61.61.6-1.6-1.4-1.6-1.11.6-1.6-1.7-1.8-1.6-1.81.6-1.6
Condit. Reinf. active responses4.15.16.92.6-2.6-2.5-2.5-2.5-2.5-2.52.42.42.3-2.3-2.2-2.3-2.31.9-1.9-2.0-2.2-2.0-1.91.9-1.9
Condit. Reinf. inactive responses0.91.12.71.6-1.5-1.4-1.4-1.4-1.3-1.31.11.11.1-1.0-1.1-1.0-1.40.6-0.6-0.5-0.7-0.5-0.40.6-0.6
Incentive salience index mean2.63.24.42.1-2.0-2.0-2.0-2.0-2.0-2.01.91.91.9-1.8-1.7-1.8-1.81.4-1.4-1.6-1.8-1.5-1.51.4-1.4
Condit. Reinf. lever presses0.20.21.01.0-0.8-0.7-0.6-0.6-0.6-0.60.30.30.2-0.2-0.3-0.1-0.7-0.30.30.20.20.30.5-0.30.3
Condit. Reinf. active minus inactive responses2.02.63.71.1-1.3-1.3-1.4-1.4-1.4-1.41.61.61.6-1.6-1.6-1.7-1.31.9-1.9-1.9-1.5-1.9-1.91.9-1.9
Condit. Reinf. active-inactive response ratio0.10.10.4-0.40.20.20.10.10.10.10.10.10.1-0.20.0-0.20.50.6-0.6-0.5-0.0-0.6-0.60.6-0.6
Condit. Reinf. active responses2.02.83.61.3-1.4-1.5-1.5-1.5-1.5-1.51.61.61.7-1.7-1.9-1.7-1.71.9-1.9-1.9-1.4-1.9-1.81.9-1.9
Condit. Reinf. inactive responses1.11.42.31.1-1.1-1.1-1.1-1.1-1.1-1.11.21.21.2-1.1-1.4-1.2-1.51.2-1.2-1.2-1.2-1.2-1.21.2-1.2
Condit. Reinf. lever presses1.72.43.21.2-1.3-1.3-1.4-1.4-1.4-1.41.51.51.6-1.6-1.5-1.6-1.31.8-1.8-1.7-1.6-1.8-1.81.8-1.8
Condit. Reinf. lever reinforcers received1.42.02.90.9-1.1-1.1-1.1-1.2-1.2-1.21.31.31.4-1.4-1.5-1.4-1.31.7-1.7-1.7-1.2-1.7-1.61.7-1.7
Conditioned reinforcement - actives0.81.42.50.7-0.9-0.9-0.9-0.9-1.0-1.01.11.11.1-1.2-1.2-1.2-0.81.6-1.6-1.4-1.4-1.0-1.51.5-1.5
Conditioned reinforcement - inactives0.00.00.2-0.40.30.30.30.30.30.2-0.2-0.2-0.20.10.20.10.50.1-0.1-0.0-0.00.3-0.1-0.10.1
Conditioned locomotion7.59.710.83.1-3.1-3.1-3.1-3.1-3.1-3.13.13.23.1-3.1-3.3-3.1-3.03.3-3.3-3.0-2.9-2.9-3.03.1-3.1
Patch foraging indifference point 0 sec0.20.30.7-0.40.40.40.50.50.50.5-0.5-0.5-0.50.60.40.60.2-0.60.60.70.80.60.7-0.50.5
Patch foraging indifference point AUC0.81.11.50.9-0.9-1.0-1.0-1.0-1.0-1.01.11.11.1-1.1-1.0-1.1-0.81.2-1.2-1.1-1.1-1.1-1.11.2-1.2
Delay disc. indifference point, 0s delay7.68.311.7-2.12.42.42.52.52.62.6-2.9-2.9-2.93.02.73.02.1-3.33.33.33.33.33.4-3.33.2
Delay disc. indifference point, 16s delay0.20.20.4-0.40.40.40.40.40.40.4-0.4-0.4-0.40.40.40.40.3-0.50.50.40.50.30.4-0.50.6
Delay disc. indifference point, 2s delay6.37.08.1-2.32.42.52.52.52.52.6-2.7-2.7-2.72.72.52.72.1-2.82.82.82.82.72.8-2.82.8
Delay disc. indifference point, 24s delay0.70.81.1-1.11.01.01.01.01.01.0-0.9-0.9-0.90.90.80.90.9-0.70.70.80.90.50.7-0.70.8
Delay disc. indifference point, 4s delay1.31.42.2-0.91.01.11.11.11.11.1-1.2-1.2-1.21.21.11.20.7-1.41.41.21.11.11.3-1.41.5
Delay disc. indifference point, 8s delay1.41.62.2-1.51.41.41.41.41.41.4-1.3-1.3-1.31.31.21.31.3-1.11.11.21.01.11.0-1.11.1
Indifference point function ln k0.10.20.4-0.60.60.60.60.60.60.6-0.5-0.5-0.50.50.40.50.3-0.40.40.40.40.50.3-0.40.4
Indifference point function log k0.10.20.4-0.60.60.60.60.60.60.6-0.5-0.5-0.50.50.40.50.3-0.40.40.40.40.50.3-0.40.4
Patch foraging total patch changes 0 sec0.10.20.4-0.30.40.40.40.40.40.4-0.5-0.5-0.50.50.30.50.2-0.50.50.60.70.50.6-0.50.5
Patch foraging total patch changes 12 sec0.40.51.3-0.90.90.80.80.80.80.8-0.7-0.7-0.70.70.90.71.1-0.50.50.70.60.50.5-0.50.5
Patch foraging total patch changes 18 sec0.81.21.31.1-1.1-1.2-1.1-1.1-1.1-1.11.11.11.1-1.1-1.1-1.1-1.11.0-1.0-1.0-1.0-1.1-1.01.1-1.1
Patch foraging total patch changes 24 sec0.10.10.10.4-0.4-0.4-0.3-0.3-0.3-0.30.30.30.3-0.3-0.3-0.3-0.30.2-0.2-0.2-0.1-0.3-0.20.3-0.3
Patch foraging total patch changes 6 sec0.20.30.40.6-0.6-0.6-0.6-0.6-0.6-0.60.50.50.5-0.5-0.6-0.5-0.60.4-0.4-0.4-0.2-0.5-0.30.5-0.5
Patch foraging time to switch 0 sec0.81.63.2-0.40.60.70.80.80.80.9-1.1-1.1-1.21.21.21.30.7-1.81.81.71.41.71.8-1.71.7
Patch foraging water rate 0 sec0.10.20.8-0.90.70.60.50.50.50.5-0.2-0.2-0.10.10.10.00.60.5-0.5-0.3-0.3-0.4-0.60.5-0.5
Patch foraging water rate 12 sec0.91.94.0-2.01.81.81.71.71.71.6-1.4-1.4-1.31.31.41.21.8-0.80.80.80.90.80.6-0.80.8
Patch foraging water rate 18 sec0.30.51.2-1.10.70.60.50.50.50.4-0.0-0.00.1-0.20.2-0.21.00.9-0.9-0.8-0.8-0.9-1.10.9-0.9
Patch foraging water rate 24 sec0.71.03.3-1.81.51.41.31.31.31.2-0.9-0.9-0.80.71.10.71.80.0-0.00.10.10.1-0.2-0.00.0
Patch foraging water rate 6 sec0.30.51.3-0.30.10.0-0.1-0.1-0.1-0.10.40.40.5-0.5-0.4-0.60.11.1-1.1-1.0-0.9-1.1-1.11.1-1.1
Seeking ratio, delayed vs. immediate footshock4.15.06.32.3-2.3-2.3-2.3-2.3-2.3-2.32.32.32.3-2.3-2.4-2.2-2.52.1-2.1-2.1-2.0-2.1-2.02.1-2.1
Distance traveled before self-admin0.20.20.4-0.30.30.40.40.40.40.4-0.5-0.5-0.50.50.30.50.2-0.40.40.60.50.70.6-0.60.6
Distance traveled after self-admin0.00.00.00.1-0.1-0.1-0.1-0.1-0.1-0.10.10.10.1-0.1-0.2-0.1-0.20.2-0.20.0-0.0-0.0-0.00.1-0.1
Extensor digitorum longus weight4.618.021.4-4.64.64.64.54.54.54.5-4.4-4.4-4.34.34.54.24.6-3.93.93.93.53.93.6-3.93.9
Bone: elastic displacement0.10.20.30.4-0.4-0.4-0.4-0.4-0.4-0.40.40.40.4-0.4-0.5-0.4-0.50.4-0.4-0.4-0.3-0.4-0.30.4-0.4
Bone: elastic work0.30.40.5-0.60.60.70.70.70.70.7-0.7-0.7-0.70.70.40.70.1-0.70.70.70.60.70.7-0.70.7
Bone: endosteal estimation0.20.30.5-0.50.50.50.50.50.50.5-0.6-0.6-0.60.60.50.60.2-0.70.70.70.40.70.6-0.70.7
Bone: endosteal perimeter0.30.61.41.0-0.9-0.9-0.9-0.9-0.9-0.90.80.80.8-0.7-0.9-0.7-1.20.5-0.5-0.6-0.7-0.6-0.50.5-0.5
Epididymis fat weight0.00.10.7-0.50.40.30.30.30.30.2-0.1-0.1-0.0-0.00.4-0.00.80.3-0.3-0.2-0.4-0.3-0.40.1-0.1
Delta time in closed arm before/after self-admin1.00.92.7-1.61.41.31.21.21.21.2-0.9-0.9-0.80.81.00.71.7-0.10.10.30.30.30.1-0.20.2
Delta time in open arm before/after self-admin0.60.60.8-0.70.70.70.70.70.70.7-0.8-0.8-0.80.80.90.80.8-0.90.90.80.70.70.8-0.90.9
Diff in mean of infusions in LGA sessions1.72.12.31.5-1.5-1.5-1.5-1.5-1.5-1.51.51.51.5-1.5-1.3-1.5-1.21.2-1.2-1.4-1.5-1.5-1.41.2-1.2
Delay discount exponential model param1.92.22.31.5-1.5-1.5-1.5-1.5-1.5-1.51.51.51.5-1.5-1.4-1.5-1.31.5-1.5-1.4-1.4-1.3-1.41.5-1.5
Extinction: sum of active levers before priming0.91.01.80.7-0.8-0.8-0.8-0.9-0.9-0.91.01.01.0-1.0-0.8-1.0-0.41.3-1.3-1.0-1.1-1.1-1.11.1-1.1
Active lever presses in extinction session 62.42.42.91.6-1.6-1.6-1.6-1.6-1.6-1.61.51.51.5-1.5-1.7-1.5-1.61.6-1.6-1.4-1.3-1.5-1.31.5-1.5
Bone: final force1.42.22.9-1.21.31.31.41.41.41.4-1.5-1.5-1.51.61.11.60.6-1.61.61.71.61.71.7-1.61.6
Bone: final moment1.11.72.4-1.01.11.21.21.21.21.2-1.4-1.4-1.41.41.01.40.5-1.51.51.51.41.51.5-1.51.5
Food consumed during 24 hour testing period0.60.81.1-1.01.01.01.01.01.01.0-0.9-0.9-0.90.90.80.90.8-0.80.80.80.70.80.7-0.80.8
Glucose2.94.65.3-2.32.32.32.32.32.32.2-2.2-2.2-2.22.22.12.22.1-2.02.02.12.32.02.0-2.02.0
Heart weight0.50.81.70.3-0.5-0.6-0.6-0.6-0.6-0.70.80.80.9-0.9-0.7-0.9-0.31.1-1.1-1.2-1.2-1.2-1.31.1-1.1
Delay discount hyperbolic model param3.33.74.01.9-1.9-1.9-1.9-1.9-1.9-1.92.02.02.0-2.0-1.8-2.0-1.62.0-2.0-1.9-1.9-1.8-1.92.0-2.0
Intermittent access intake day 1-15 change3.26.78.52.1-2.3-2.3-2.4-2.4-2.4-2.42.62.62.6-2.6-2.6-2.6-2.12.9-2.9-2.7-2.7-2.7-2.82.9-2.9
Intermittent access intake escalation2.95.97.42.0-2.2-2.2-2.2-2.2-2.2-2.32.42.42.4-2.5-2.4-2.5-2.02.7-2.7-2.6-2.5-2.5-2.62.7-2.7
Intermittent access intake escalation 24.65.26.52.0-2.1-2.1-2.1-2.2-2.2-2.22.32.32.3-2.3-2.3-2.3-2.02.5-2.5-2.4-2.3-2.4-2.52.5-2.5
Intermitt. access day 1 inactive lever presses0.10.20.7-0.40.20.20.10.10.10.00.20.20.2-0.3-0.1-0.30.40.8-0.8-0.5-0.6-0.5-0.70.6-0.6
Intermitt. access day 15 inactive lever presses0.20.50.60.8-0.8-0.8-0.8-0.8-0.8-0.70.70.70.7-0.7-0.7-0.7-0.70.6-0.6-0.6-0.7-0.6-0.60.6-0.6
Intermitt. access escalation Index0.60.91.5-0.50.60.70.70.70.70.7-0.9-0.9-0.91.00.71.00.3-1.21.21.11.21.21.2-1.11.1
Intermittent access day 1 total infusions0.10.10.4-0.0-0.1-0.1-0.1-0.2-0.2-0.20.30.30.3-0.3-0.3-0.40.00.6-0.6-0.5-0.6-0.4-0.60.4-0.4
Intermittent access day 15 total infusions2.43.65.01.6-1.7-1.7-1.7-1.8-1.8-1.81.91.91.9-1.9-1.9-2.0-1.62.2-2.2-2.0-2.0-2.0-2.12.0-2.0
Intermittent access terminal intake (last 3 days)1.82.43.51.3-1.4-1.4-1.4-1.4-1.4-1.51.51.51.5-1.5-1.6-1.6-1.31.9-1.9-1.6-1.6-1.6-1.71.6-1.6
Intermittent access total infusions0.91.11.80.8-0.9-0.9-0.9-0.9-0.9-1.01.01.01.0-1.1-1.1-1.1-0.81.4-1.4-1.1-1.2-1.1-1.21.1-1.1
Intermittent access day 1 locomotion1.31.72.80.8-1.0-1.0-1.1-1.1-1.1-1.11.31.31.3-1.4-1.1-1.4-0.61.7-1.7-1.6-1.7-1.4-1.71.4-1.4
Intermittent access day 15 total locomotion2.95.37.01.9-2.1-2.1-2.2-2.2-2.2-2.22.32.32.4-2.4-2.2-2.4-1.72.6-2.6-2.5-2.5-2.3-2.62.4-2.4
Intermittent access total locomotion2.32.84.01.3-1.4-1.5-1.5-1.5-1.5-1.51.71.71.7-1.7-1.6-1.7-1.22.0-2.0-1.8-1.9-1.6-1.91.8-1.8
Intermittent access standard deviation3.77.78.82.6-2.7-2.7-2.7-2.7-2.7-2.72.82.82.8-2.8-2.9-2.8-2.73.0-3.0-2.8-2.8-2.7-2.82.8-2.8
Left kidney weight0.00.10.4-0.60.50.40.40.40.40.3-0.2-0.2-0.20.10.20.10.60.2-0.2-0.1-0.40.0-0.30.2-0.2
Right kidney weight0.41.83.50.7-0.9-1.0-1.0-1.0-1.0-1.11.31.31.3-1.3-1.3-1.4-0.91.7-1.7-1.6-1.9-1.5-1.81.6-1.6
Cocaine induced anxiety1.21.83.21.8-1.7-1.6-1.6-1.6-1.6-1.51.41.41.3-1.3-1.4-1.3-1.70.9-0.9-1.0-0.9-0.9-0.81.0-1.0
Post-drug Anxiety1.51.63.21.8-1.6-1.6-1.6-1.6-1.5-1.51.31.31.3-1.2-1.2-1.2-1.50.7-0.7-0.9-0.9-0.9-0.70.7-0.7
Baseline Anxiety0.00.10.10.1-0.2-0.2-0.2-0.2-0.2-0.20.20.20.2-0.2-0.2-0.3-0.20.3-0.3-0.3-0.3-0.3-0.30.1-0.1
Tail length3.513.515.33.3-3.5-3.5-3.5-3.6-3.6-3.63.73.73.7-3.7-3.8-3.7-3.63.8-3.8-3.7-3.9-3.8-3.83.8-3.8
Length with tail2.08.510.02.7-2.8-2.8-2.9-2.9-2.9-2.92.92.93.0-3.0-2.9-3.0-2.73.0-3.0-3.0-3.2-3.0-3.03.0-3.0
Length without tail0.00.00.1-0.20.20.20.20.20.20.2-0.1-0.1-0.10.10.20.10.2-0.10.10.10.10.10.1-0.10.1
Times rat made contact with spout0.20.30.7-0.80.70.70.70.70.70.6-0.5-0.5-0.50.50.50.50.7-0.20.20.30.30.20.2-0.20.2
Lifetime Intake0.50.61.20.5-0.6-0.6-0.6-0.6-0.6-0.60.70.70.7-0.8-0.7-0.8-0.51.1-1.1-0.8-0.9-0.7-0.90.8-0.7
Liver weight, left1.01.71.9-1.41.41.41.31.31.31.3-1.3-1.3-1.31.31.41.31.4-1.21.21.21.21.21.1-1.31.3
Liver weight, right0.71.21.8-1.31.31.31.21.21.21.2-1.1-1.1-1.11.11.11.11.2-0.80.80.90.71.00.8-0.91.0
Locomotor activity3.35.18.22.6-2.5-2.5-2.5-2.4-2.4-2.42.22.22.2-2.2-2.6-2.1-2.92.1-2.1-1.8-1.7-2.0-1.72.0-2.0
Locomotor testing distance1.83.25.12.1-2.0-2.0-2.0-2.0-2.0-1.91.81.81.8-1.7-2.1-1.7-2.31.6-1.6-1.5-1.3-1.6-1.31.6-1.6
Locomotor testing rearing0.00.00.1-0.20.10.10.00.00.00.00.10.10.1-0.1-0.2-0.1-0.00.4-0.4-0.3-0.1-0.4-0.30.3-0.3
Locomotion in novel chamber0.91.21.80.8-0.9-0.9-1.0-1.0-1.0-1.01.01.01.1-1.1-1.1-1.1-0.81.3-1.3-1.2-1.0-1.1-1.21.3-1.3
Locomotion in novel chamber post-restriction1.11.82.31.1-1.2-1.2-1.2-1.2-1.2-1.31.31.31.3-1.3-1.4-1.4-1.31.5-1.5-1.4-1.5-1.4-1.51.4-1.4
Fecal boli incidents, locomotor time 11.31.92.8-1.41.41.41.41.41.41.4-1.4-1.4-1.41.41.61.41.7-1.31.31.41.21.41.3-1.31.2
Change in fecal boli incidents, locomotor task0.20.21.20.5-0.5-0.5-0.5-0.4-0.4-0.50.40.40.4-0.3-0.8-0.4-1.10.4-0.4-0.3-0.2-0.2-0.30.4-0.5
Time >=10cm from walls, locomotor time 10.40.41.2-0.20.40.40.50.50.50.5-0.7-0.7-0.70.70.30.70.0-0.60.61.01.11.01.0-0.60.7
Bouts of movement, locomotor time 10.30.40.70.5-0.5-0.5-0.5-0.5-0.5-0.50.60.60.6-0.6-0.6-0.6-0.50.7-0.7-0.6-0.8-0.5-0.70.7-0.7
Total resting periods, locomotor time 10.40.50.80.6-0.6-0.6-0.7-0.7-0.7-0.70.70.70.7-0.7-0.7-0.7-0.70.7-0.7-0.7-0.9-0.6-0.70.7-0.7
Rest time, locomotor task time 10.30.40.70.7-0.7-0.7-0.7-0.7-0.7-0.70.60.60.6-0.6-0.6-0.6-0.60.4-0.4-0.5-0.8-0.4-0.50.4-0.5
Distance moved, locomotor task time 10.50.81.9-0.50.60.70.70.70.70.7-0.9-0.9-0.91.00.51.00.2-1.01.01.11.41.01.3-1.01.1
Vertical activity count, locomotor time 10.20.40.8-0.90.80.80.80.80.80.7-0.7-0.7-0.60.60.40.60.3-0.30.30.40.90.40.4-0.30.3
Time >=10cm from walls, locomotor time 21.11.72.3-1.51.51.51.51.51.51.5-1.4-1.4-1.41.41.11.31.2-0.90.91.31.21.11.1-0.91.0
Bouts of movement, locomotor time 20.30.51.11.1-1.0-0.9-0.9-0.9-0.9-0.90.70.70.7-0.7-0.7-0.6-0.90.3-0.3-0.4-0.5-0.5-0.30.3-0.3
Total resting periods, locomotor time 20.30.41.11.0-0.9-0.9-0.9-0.9-0.9-0.80.70.70.6-0.6-0.6-0.6-0.90.3-0.3-0.4-0.4-0.4-0.20.3-0.2
Rest time, locomotor task time 20.70.81.31.1-1.1-1.1-1.0-1.0-1.0-1.00.90.90.9-0.9-1.0-0.9-1.10.7-0.7-0.7-0.8-0.8-0.60.7-0.6
Distance moved, locomotor task time 20.60.81.1-1.01.01.01.01.01.00.9-0.9-0.9-0.90.90.90.91.0-0.70.70.80.70.70.7-0.70.7
Vertical activity count, locomotor time 20.50.81.5-1.21.11.11.11.11.01.0-0.9-0.9-0.90.81.00.81.2-0.50.50.60.50.60.5-0.50.4
Light reinforcement 14.611.313.93.7-3.7-3.7-3.6-3.6-3.6-3.63.53.53.5-3.4-3.4-3.4-3.42.9-2.9-3.1-3.1-3.0-2.93.1-3.1
Light reinforcement 21.93.03.82.0-1.9-1.9-1.9-1.9-1.9-1.91.81.81.8-1.8-1.8-1.7-1.91.5-1.5-1.6-1.4-1.5-1.41.5-1.5
Bone: marrow area0.20.30.5-0.50.50.50.50.50.50.5-0.6-0.6-0.60.60.50.60.3-0.70.70.70.40.70.6-0.70.7
Bone: maximum diameter0.91.73.31.6-1.5-1.5-1.5-1.5-1.5-1.41.31.31.3-1.2-1.5-1.2-1.81.0-1.0-1.0-1.0-1.0-0.91.0-1.0
Bone: maximum force1.32.32.8-1.31.41.51.51.51.51.5-1.6-1.6-1.61.61.21.60.8-1.61.61.71.51.61.6-1.61.6
Bone: maximum moment1.11.92.4-1.21.31.31.41.41.41.4-1.4-1.4-1.41.51.11.50.7-1.51.51.51.41.51.5-1.51.5
Mean time between licks in bursts2.66.36.72.4-2.4-2.5-2.5-2.5-2.5-2.52.62.62.6-2.6-2.5-2.6-2.32.6-2.6-2.6-2.3-2.6-2.52.6-2.6
Mean num. licks in bursts0.00.00.10.00.00.10.10.10.10.1-0.1-0.1-0.20.20.10.2-0.0-0.30.30.20.10.30.3-0.30.3
Cd content in liver0.20.20.30.5-0.5-0.5-0.5-0.5-0.5-0.50.50.50.4-0.4-0.5-0.4-0.50.4-0.4-0.4-0.1-0.4-0.30.4-0.4
Co content in liver1.61.92.31.2-1.2-1.3-1.3-1.3-1.3-1.31.41.41.4-1.4-1.4-1.4-1.21.5-1.5-1.5-1.2-1.5-1.41.5-1.5
Cu content in liver0.20.30.90.9-0.8-0.7-0.7-0.7-0.7-0.60.50.50.5-0.4-0.6-0.4-0.90.2-0.2-0.2-0.1-0.2-0.10.2-0.2
Fe content in liver0.10.20.30.3-0.3-0.4-0.4-0.4-0.4-0.40.40.40.4-0.4-0.3-0.4-0.10.5-0.5-0.5-0.6-0.5-0.50.5-0.5
K content in liver0.10.10.30.5-0.4-0.4-0.4-0.3-0.3-0.30.20.20.2-0.1-0.3-0.1-0.5-0.10.10.10.20.10.2-0.10.1
Mg content in liver0.30.30.50.7-0.7-0.7-0.6-0.6-0.6-0.60.60.60.6-0.5-0.6-0.5-0.70.5-0.5-0.5-0.3-0.5-0.30.5-0.5
Mn content in liver1.71.94.71.9-1.7-1.7-1.6-1.6-1.6-1.61.31.31.3-1.2-1.7-1.2-2.20.8-0.8-0.9-0.9-0.8-0.70.8-0.8
Na content in liver0.80.81.6-0.40.50.60.60.60.60.7-0.9-0.9-0.90.90.80.90.5-1.21.21.21.11.21.3-1.21.2
Rb content in liver0.10.10.50.6-0.5-0.4-0.4-0.4-0.4-0.30.20.20.1-0.1-0.4-0.1-0.7-0.20.20.20.30.20.3-0.20.2
Se content in liver0.20.30.40.5-0.5-0.5-0.5-0.5-0.5-0.50.50.50.5-0.6-0.5-0.5-0.40.5-0.5-0.5-0.6-0.5-0.50.5-0.5
Sr content in liver0.00.00.1-0.30.20.20.20.20.20.2-0.1-0.1-0.10.10.20.10.30.0-0.0-0.0-0.0-0.0-0.10.0-0.0
Zn content in liver3.74.16.31.3-1.6-1.6-1.7-1.7-1.7-1.72.02.02.0-2.1-1.7-2.1-1.12.4-2.4-2.4-2.2-2.4-2.52.4-2.4
Bone: minimum diameter0.00.00.20.1-0.0-0.00.00.00.00.0-0.1-0.1-0.10.2-0.10.1-0.4-0.30.30.30.10.30.3-0.30.3
Time in familiar zone, hab. session 12.32.23.41.2-1.3-1.3-1.4-1.4-1.4-1.41.51.51.5-1.5-1.4-1.5-1.21.5-1.5-1.6-1.8-1.7-1.71.5-1.5
Time in novel zone, hab. session 11.11.12.1-0.70.80.80.90.90.90.9-1.1-1.0-1.11.10.81.10.4-1.21.21.31.41.31.4-1.21.2
Total zone transitions, hab. session 11.01.43.11.8-1.6-1.5-1.5-1.5-1.5-1.41.21.21.2-1.1-1.2-1.1-1.50.7-0.7-0.8-0.7-0.9-0.50.7-0.7
Total locomotion distance, hab. session 11.31.94.42.1-1.9-1.8-1.8-1.7-1.7-1.71.41.41.3-1.2-1.5-1.2-2.00.7-0.7-0.8-0.9-0.9-0.50.7-0.7
Locomotion velocity, hab. session 11.92.65.42.3-2.1-2.1-2.0-2.0-2.0-1.91.71.71.6-1.5-1.7-1.5-2.11.0-1.0-1.1-1.2-1.2-0.81.0-1.0
Time in familiar zone, hab. session 26.56.98.82.2-2.4-2.4-2.5-2.5-2.5-2.52.72.72.7-2.7-2.5-2.8-2.02.8-2.8-2.8-2.9-2.8-3.02.8-2.8
Time in novel zone, hab. session 25.05.16.5-1.82.02.12.12.12.12.1-2.3-2.3-2.32.42.02.41.6-2.42.42.42.62.42.6-2.42.4
Total zone transitions, hab. session 20.30.41.30.7-0.4-0.3-0.2-0.2-0.2-0.2-0.2-0.2-0.30.30.20.4-0.3-0.90.90.80.90.81.1-0.90.9
Total locomotion distance, hab. session 21.31.73.81.9-1.8-1.7-1.7-1.7-1.6-1.61.41.41.3-1.3-1.2-1.2-1.50.7-0.7-0.9-0.9-1.0-0.60.7-0.7
Locomotion velocity, hab. session 21.31.84.42.1-1.9-1.8-1.7-1.7-1.7-1.71.41.41.3-1.3-1.2-1.2-1.60.6-0.6-0.8-0.8-0.9-0.50.6-0.6
Novel to familiar place preference ratio4.24.66.4-1.61.81.81.91.91.91.9-2.1-2.1-2.22.21.92.21.4-2.42.42.42.52.52.5-2.42.4
Novelty place preference2.52.74.1-1.11.31.41.41.41.41.5-1.6-1.6-1.71.71.41.71.0-1.91.91.91.92.02.0-1.91.9
Time in novel zone, NPP test2.93.14.4-1.31.51.51.61.61.61.6-1.8-1.8-1.81.81.61.91.1-2.02.02.02.02.12.1-2.02.0
Total zone transitions, NPP test0.10.10.60.8-0.5-0.5-0.4-0.4-0.4-0.40.10.10.1-0.10.00.0-0.2-0.40.40.30.50.20.6-0.40.4
Total locomotion distance, NPP test0.10.10.50.7-0.5-0.5-0.4-0.4-0.4-0.30.10.10.1-0.0-0.00.0-0.4-0.50.50.30.30.20.6-0.50.5
Locomotion velocity, NPP test0.20.21.01.0-0.8-0.8-0.7-0.7-0.7-0.60.40.40.3-0.3-0.3-0.3-0.6-0.20.20.00.1-0.10.3-0.20.2
Intraocular pressure0.10.20.8-0.70.50.50.40.40.40.4-0.1-0.1-0.10.00.4-0.00.90.4-0.4-0.3-0.4-0.3-0.50.4-0.4
Delta distance traveled before/after self-admin0.40.50.80.6-0.6-0.6-0.6-0.6-0.6-0.60.70.70.7-0.7-0.7-0.7-0.60.7-0.7-0.7-0.7-0.8-0.70.9-0.9
Delta ambulatory time before/after self-admin0.40.50.70.7-0.7-0.7-0.7-0.7-0.7-0.70.70.70.7-0.7-0.7-0.7-0.80.6-0.6-0.7-0.7-0.7-0.70.8-0.8
Parametrial fat weight0.00.00.00.2-0.2-0.1-0.1-0.1-0.1-0.10.00.00.0-0.0-0.1-0.0-0.2-0.00.00.2-0.00.20.2-0.10.1
Pavlov. Cond. lever latency0.10.10.5-0.70.50.50.40.40.40.4-0.2-0.2-0.10.10.20.10.60.3-0.3-0.2-0.0-0.1-0.40.3-0.3
Pavlov. Cond. magazine entry latency3.54.55.32.2-2.2-2.2-2.2-2.2-2.2-2.22.22.22.2-2.2-1.9-2.2-1.82.0-2.0-2.1-2.3-2.0-2.12.0-2.0
Pavlov. Cond. change in total contacts0.10.10.20.4-0.4-0.4-0.4-0.4-0.4-0.40.30.30.3-0.3-0.2-0.3-0.20.2-0.2-0.2-0.4-0.2-0.20.2-0.2
Pavlov. Cond. index score0.60.71.31.2-1.1-1.1-1.0-1.0-1.0-1.00.90.90.9-0.8-0.8-0.8-0.90.5-0.5-0.6-0.9-0.7-0.60.5-0.5
Pavlov. Cond. latency score0.60.71.61.3-1.2-1.1-1.1-1.1-1.1-1.00.90.90.8-0.8-0.8-0.8-1.00.4-0.4-0.6-0.8-0.6-0.40.4-0.4
Pavlov. Cond. lever contacts0.10.10.40.6-0.5-0.4-0.4-0.4-0.3-0.30.10.10.1-0.0-0.1-0.0-0.5-0.30.30.20.00.10.4-0.30.3
Pavlov. Cond. magazine entry number1.01.21.7-1.11.21.21.21.21.21.2-1.2-1.2-1.21.20.91.20.8-1.01.01.11.31.11.1-1.01.0
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.1-0.0-0.1-0.1-0.1-0.1-0.20.30.30.3-0.4-0.2-0.40.10.6-0.6-0.6-0.5-0.6-0.60.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.70.91.51.2-1.2-1.1-1.1-1.1-1.1-1.11.01.01.0-1.0-0.9-0.9-1.00.6-0.6-0.8-1.0-0.8-0.70.6-0.6
Pavlov. Cond. response bias1.01.21.61.2-1.2-1.2-1.2-1.2-1.2-1.21.11.11.1-1.1-0.9-1.1-0.91.0-1.0-1.1-1.3-1.1-1.01.0-1.0
Pavlov. Cond. lever latency0.60.91.4-0.70.80.80.80.80.80.8-0.9-0.9-0.90.91.20.91.2-1.11.11.00.81.11.0-1.11.1
Pavlov. Cond. magazine entry latency0.40.50.70.6-0.6-0.6-0.6-0.6-0.6-0.60.70.70.7-0.7-0.8-0.7-0.80.7-0.7-0.7-0.8-0.7-0.70.7-0.7
Pavlov. Cond. change in total contacts0.40.71.10.5-0.6-0.6-0.6-0.7-0.7-0.70.80.80.8-0.8-1.0-0.8-0.91.0-1.0-1.0-0.6-1.0-0.91.0-1.0
Pavlov. Cond. index score0.50.71.10.6-0.7-0.7-0.7-0.7-0.7-0.70.80.80.8-0.8-1.1-0.8-1.01.0-1.0-0.9-0.8-1.0-0.91.0-1.0
Pavlov. Cond. latency score0.60.81.30.7-0.8-0.8-0.8-0.8-0.8-0.80.80.80.8-0.8-1.1-0.9-1.11.0-1.0-0.9-0.8-1.0-0.91.0-1.0
Pavlov. Cond. lever contacts0.50.61.00.5-0.6-0.6-0.6-0.6-0.6-0.60.70.70.7-0.7-1.0-0.8-0.91.0-1.0-0.9-0.8-1.0-0.91.0-1.0
Pavlov. Cond. magazine entry number0.60.81.3-0.80.80.80.90.90.90.9-0.9-0.9-0.90.91.10.91.1-0.90.90.90.90.90.9-0.90.9
Pavlov. Cond. intertrial magazine entries0.30.50.8-0.90.80.80.80.80.80.8-0.7-0.7-0.70.60.70.60.9-0.50.50.50.60.50.4-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.60.81.30.7-0.8-0.8-0.8-0.8-0.8-0.80.90.90.9-0.8-1.1-0.9-1.11.0-1.0-0.9-0.8-1.0-0.91.0-1.0
Pavlov. Cond. response bias1.41.92.61.0-1.1-1.1-1.2-1.2-1.2-1.21.31.31.3-1.3-1.5-1.4-1.41.6-1.6-1.5-1.4-1.6-1.61.6-1.6
Time in closed arm before self-admin0.30.40.9-0.10.30.30.30.40.40.4-0.6-0.6-0.60.60.50.60.2-0.90.90.80.81.01.0-0.80.8
Time in closed arm after self-admin0.20.20.30.1-0.2-0.2-0.2-0.3-0.3-0.30.40.40.4-0.4-0.3-0.4-0.00.5-0.5-0.5-0.5-0.6-0.60.6-0.6
Time in open arm before self-admin0.20.20.50.4-0.4-0.4-0.4-0.4-0.4-0.40.30.30.3-0.3-0.6-0.3-0.70.4-0.4-0.3-0.2-0.2-0.30.6-0.6
Time in open arm after self-admin1.01.11.3-1.11.11.11.11.11.11.1-1.1-1.1-1.11.11.01.10.9-1.11.11.01.01.11.0-1.01.0
Bone: periosteal estimation0.20.50.9-0.30.40.40.40.50.50.5-0.6-0.6-0.60.70.30.7-0.1-0.90.90.90.70.90.9-0.90.9
Bone: periosteal perimeter0.10.21.10.7-0.6-0.6-0.5-0.5-0.5-0.50.40.40.3-0.3-0.7-0.3-1.00.1-0.1-0.1-0.2-0.1-0.00.1-0.1
Bone: post-yield work0.71.01.2-1.11.11.11.11.11.11.1-1.0-1.0-1.01.01.01.00.9-1.01.00.90.70.90.9-1.01.0
Progressive ratio test 1 active lever presses0.10.10.4-0.30.10.10.00.00.0-0.00.20.20.2-0.2-0.1-0.30.30.5-0.5-0.5-0.6-0.4-0.60.3-0.3
Progressive ratio test 1 breakpoint0.10.10.3-0.30.10.10.10.10.10.00.10.10.2-0.2-0.0-0.20.30.5-0.5-0.4-0.6-0.4-0.60.3-0.3
Progressive ratio test 1 inactive lever presses0.20.30.70.4-0.4-0.5-0.5-0.5-0.5-0.50.60.60.6-0.6-0.4-0.6-0.20.7-0.7-0.7-0.8-0.5-0.80.6-0.6
Progressive ratio test 2 active lever presses0.20.30.9-0.2-0.0-0.0-0.1-0.1-0.1-0.10.30.30.4-0.4-0.3-0.40.10.9-0.9-0.7-0.7-0.5-0.80.7-0.6
Progressive ratio test 2 breakpoint0.30.31.0-0.1-0.1-0.1-0.2-0.2-0.2-0.20.40.40.4-0.5-0.4-0.50.11.0-1.0-0.8-0.8-0.6-0.90.7-0.7
Progressive ratio test 2 inactive lever presses0.10.10.40.3-0.3-0.3-0.3-0.3-0.3-0.40.40.40.4-0.4-0.4-0.4-0.20.6-0.6-0.4-0.4-0.2-0.40.4-0.3
Incentive Sensitization - Responses0.10.10.5-0.60.50.50.40.40.40.4-0.2-0.2-0.20.10.30.10.70.4-0.4-0.1-0.10.2-0.20.2-0.2
Incentive Sensitization - Breakpoint0.10.10.3-0.40.30.30.30.20.20.2-0.1-0.1-0.10.00.1-0.00.60.5-0.5-0.2-0.20.1-0.30.3-0.3
Sum of active levers in priming session hrs 5-60.00.00.0-0.10.10.10.10.10.10.1-0.1-0.1-0.10.10.10.10.1-0.10.10.10.10.10.1-0.00.0
Progressive ratio0.20.41.4-0.70.60.60.60.60.60.6-0.5-0.5-0.50.51.00.51.2-0.60.60.50.20.40.4-0.50.5
Food seeking constrained by brief footshock0.30.30.70.8-0.8-0.8-0.7-0.7-0.7-0.70.60.60.6-0.6-0.3-0.6-0.10.4-0.4-0.4-0.6-0.3-0.40.3-0.3
Seeking ratio, punishment vs. effort0.30.50.90.9-0.9-0.9-0.8-0.8-0.8-0.80.70.70.7-0.7-0.8-0.7-0.90.5-0.5-0.5-0.4-0.5-0.40.4-0.4
Retroperitoneal fat weight0.41.94.2-1.61.61.51.51.51.51.5-1.3-1.3-1.31.31.71.32.1-1.11.11.10.81.00.9-1.21.2
Reaction time number correct0.40.82.1-1.51.31.21.21.21.21.1-0.9-0.9-0.90.80.90.81.3-0.40.40.40.50.40.2-0.40.4
Reaction time mean minus median0.30.60.90.6-0.6-0.7-0.7-0.7-0.7-0.70.80.80.8-0.8-0.8-0.8-0.80.9-0.9-0.9-0.9-0.9-0.90.9-0.9
Reaction time mean minus median AUC0.00.00.20.2-0.1-0.1-0.1-0.1-0.1-0.1-0.0-0.0-0.10.1-0.20.1-0.5-0.30.30.20.10.30.3-0.30.3
Reaction time num false alarms0.20.30.9-1.00.80.80.80.80.80.7-0.6-0.6-0.50.50.40.50.5-0.20.20.20.20.20.1-0.20.2
Reaction time num false alarms AUC0.20.41.1-1.10.90.90.80.80.80.8-0.6-0.6-0.60.50.50.50.7-0.10.10.20.20.20.1-0.20.2
Reaction time trials correct on left0.40.82.1-1.51.31.21.21.21.21.1-0.9-0.9-0.90.80.90.81.3-0.40.40.40.50.40.2-0.40.4
Reaction time trials on left0.40.82.0-1.41.31.21.21.21.21.1-0.9-0.9-0.90.80.90.81.2-0.40.40.40.50.50.3-0.50.5
Reaction time mean0.00.10.1-0.10.10.10.10.20.20.2-0.2-0.2-0.20.3-0.00.2-0.3-0.30.30.30.30.30.4-0.30.3
Reaction time mean AUC0.10.10.2-0.10.20.20.20.20.20.2-0.3-0.3-0.30.30.00.3-0.2-0.40.40.30.40.40.4-0.30.3
Median of all reaction times0.30.40.7-0.40.50.50.50.50.50.5-0.6-0.6-0.60.70.40.70.1-0.80.80.70.80.80.8-0.70.7
Reaction time omissions0.10.20.50.7-0.6-0.6-0.6-0.6-0.5-0.50.40.40.4-0.4-0.5-0.4-0.60.3-0.3-0.2-0.2-0.1-0.10.2-0.2
Reaction time false alarm rate0.00.10.1-0.30.30.30.30.30.30.3-0.3-0.3-0.30.30.10.30.1-0.20.20.20.20.20.2-0.20.2
Reaction time premature initiation rate0.91.21.70.8-0.9-0.9-1.0-1.0-1.0-1.01.11.11.1-1.2-1.0-1.2-0.81.3-1.3-1.2-1.2-1.3-1.31.3-1.3
Reaction time premature initiations0.40.71.70.1-0.3-0.4-0.4-0.5-0.5-0.50.70.70.8-0.8-0.6-0.9-0.21.2-1.2-1.2-1.1-1.2-1.31.2-1.2
Std. dev. reaction times0.10.10.30.3-0.3-0.3-0.3-0.3-0.3-0.30.30.30.3-0.3-0.5-0.3-0.50.3-0.3-0.4-0.4-0.3-0.30.4-0.4
Reaction time trials completed0.40.82.0-1.41.31.21.21.21.21.1-0.9-0.9-0.90.80.90.81.2-0.40.40.40.50.50.3-0.50.5
Reaction time trials AUC0.40.82.3-1.51.31.31.21.21.21.2-0.9-0.9-0.90.81.00.81.3-0.40.40.30.40.40.2-0.40.4
Run reversals in cocaine runway, females0.70.71.11.0-1.0-0.9-0.9-0.9-0.9-0.90.80.80.8-0.8-0.9-0.8-1.00.6-0.6-0.7-0.8-0.6-0.60.5-0.5
Run reversals in cocaine runway, males1.92.02.61.6-1.6-1.6-1.5-1.5-1.5-1.51.51.51.4-1.4-1.4-1.4-1.51.2-1.2-1.3-1.3-1.3-1.21.1-1.1
Latency to leave start box in cocaine runway0.50.51.91.0-0.9-0.9-0.9-0.8-0.8-0.80.70.70.6-0.6-1.1-0.6-1.40.6-0.6-0.30.0-0.4-0.20.4-0.4
Latency to leave start box in cocaine runway, F0.20.21.00.5-0.3-0.2-0.2-0.1-0.1-0.1-0.1-0.1-0.10.2-0.40.2-0.8-0.20.20.61.00.60.7-0.50.6
Latency to leave start box in cocaine runway, M1.91.72.31.0-1.1-1.2-1.2-1.2-1.2-1.21.31.31.3-1.4-1.3-1.4-1.11.4-1.4-1.5-1.4-1.4-1.51.5-1.5
Std. dev. time between licks in bursts0.70.92.21.0-1.0-1.0-1.0-1.0-1.0-1.00.90.90.9-0.9-1.3-0.9-1.50.8-0.8-0.9-0.5-0.8-0.70.8-0.8
Total sessions with >9 infusions0.20.30.80.2-0.3-0.3-0.3-0.3-0.3-0.30.40.40.4-0.5-0.5-0.5-0.20.9-0.9-0.6-0.7-0.4-0.70.6-0.6
Short access day 1 total inactive lever presses0.30.40.70.5-0.6-0.6-0.6-0.6-0.6-0.60.60.60.7-0.7-0.5-0.7-0.30.8-0.8-0.7-0.8-0.5-0.70.7-0.7
Short access day 10 total inactive lever presses0.00.00.2-0.30.30.20.20.20.20.2-0.1-0.1-0.10.10.20.10.50.3-0.3-0.0-0.0-0.2-0.10.3-0.3
Short access day 1 total infusions0.30.40.60.6-0.6-0.6-0.6-0.6-0.6-0.60.70.70.7-0.7-0.6-0.7-0.50.7-0.7-0.7-0.8-0.5-0.70.6-0.6
Short access day 10 total infusions0.10.10.3-0.1-0.0-0.0-0.0-0.1-0.1-0.10.20.20.2-0.2-0.1-0.30.20.5-0.5-0.4-0.5-0.3-0.50.2-0.2
Short access total infusions0.20.30.80.3-0.4-0.4-0.4-0.4-0.4-0.50.50.50.5-0.6-0.5-0.6-0.30.9-0.9-0.6-0.7-0.5-0.70.5-0.5
Short access day 1 locomotion1.31.72.31.1-1.2-1.2-1.2-1.2-1.2-1.21.31.31.3-1.3-1.3-1.3-1.11.5-1.5-1.4-1.4-1.1-1.41.3-1.3
Short access day 10 total locomotion4.07.310.92.0-2.3-2.3-2.4-2.4-2.4-2.52.72.72.7-2.8-2.6-2.8-2.03.3-3.3-3.0-3.0-2.8-3.13.0-3.0
Short access total locomotion2.22.64.31.3-1.4-1.4-1.4-1.5-1.5-1.51.61.61.6-1.6-1.7-1.7-1.32.1-2.1-1.7-1.8-1.5-1.81.7-1.7
One hour access (0.3 mA shock)0.00.00.1-0.30.20.20.20.20.20.2-0.1-0.1-0.10.10.10.10.30.1-0.1-0.0-0.10.2-0.1-0.10.2
Compulsive drug intake1.01.22.3-0.60.70.80.80.80.90.9-1.1-1.1-1.11.10.81.20.4-1.31.31.41.51.51.5-1.41.4
One hour access (shock baseline)0.40.61.30.3-0.4-0.5-0.5-0.5-0.5-0.60.70.70.7-0.8-0.6-0.8-0.31.0-1.0-1.0-1.1-0.9-1.10.8-0.8
Social response proportion0.91.01.61.3-1.2-1.2-1.2-1.2-1.2-1.21.11.11.0-1.0-1.0-1.0-1.10.8-0.8-0.9-0.7-0.9-0.70.8-0.8
Social responses7.49.511.43.2-3.2-3.2-3.2-3.2-3.2-3.23.13.13.1-3.1-3.3-3.1-3.43.0-3.0-2.9-2.8-2.9-2.72.9-2.9
Social time0.40.60.9-0.60.70.70.70.70.70.7-0.7-0.7-0.70.70.90.70.9-0.70.70.81.00.70.8-0.70.7
Soleus weight8.826.027.2-5.15.25.25.25.25.25.2-5.2-5.2-5.25.25.05.24.7-5.05.05.14.95.14.9-5.05.0
Bone: stiffness2.74.45.3-1.81.92.02.02.02.02.0-2.1-2.1-2.12.21.92.21.5-2.32.32.32.12.32.2-2.32.3
Tibialis anterior weight1.23.94.1-2.02.02.02.02.02.02.0-2.0-2.0-2.02.02.02.01.9-2.02.01.91.71.91.8-2.02.0
Time to tail flick, vehicle, before self-admin0.10.10.20.5-0.4-0.4-0.4-0.4-0.4-0.40.30.30.3-0.3-0.3-0.3-0.30.1-0.1-0.2-0.2-0.2-0.10.2-0.2
Time to tail flick, vehicle, after self-admin0.30.41.10.0-0.2-0.2-0.3-0.3-0.3-0.30.50.50.6-0.6-0.1-0.60.30.7-0.7-0.8-1.0-1.0-1.00.7-0.7
Time to tail flick, test, before self-admin0.40.41.10.8-0.7-0.7-0.7-0.7-0.7-0.70.60.60.6-0.5-0.8-0.5-1.00.3-0.3-0.4-0.4-0.2-0.30.5-0.5
Time to tail flick, test, after self-admin0.10.10.10.3-0.3-0.3-0.3-0.3-0.3-0.30.30.30.3-0.3-0.3-0.3-0.30.2-0.2-0.4-0.4-0.4-0.30.3-0.3
Delta time to tail flick, vehicle, before/after SA0.30.31.4-0.90.80.70.70.70.70.6-0.4-0.4-0.40.40.80.31.2-0.10.10.1-0.0-0.0-0.1-0.30.3
Delta time to tail flick, test, before/after SA0.10.10.4-0.40.30.30.20.20.20.2-0.0-0.0-0.0-0.00.3-0.00.60.2-0.2-0.3-0.3-0.3-0.40.2-0.2
Tibia length0.92.42.91.4-1.4-1.5-1.5-1.5-1.5-1.51.51.51.5-1.5-1.5-1.5-1.41.6-1.6-1.6-1.6-1.7-1.61.6-1.6
Ambulatory time before self-admin0.10.20.4-0.30.40.40.40.40.40.4-0.5-0.5-0.50.50.40.50.3-0.40.40.60.60.60.6-0.60.6
Ambulatory time after self-admin0.00.00.00.1-0.1-0.1-0.0-0.0-0.0-0.0-0.0-0.0-0.00.0-0.10.0-0.20.0-0.00.10.10.10.1-0.00.0
Bone: tissue strength2.02.02.4-1.21.31.31.31.31.31.4-1.4-1.4-1.41.51.41.51.2-1.51.51.51.51.51.5-1.51.5
Total heroin consumption1.61.92.31.5-1.5-1.5-1.5-1.5-1.5-1.51.41.41.4-1.4-1.4-1.4-1.41.3-1.3-1.3-1.3-1.3-1.21.3-1.3
Bone: trabecular number0.40.71.91.3-1.1-1.1-1.1-1.0-1.0-1.00.80.80.8-0.7-1.0-0.7-1.40.4-0.4-0.5-0.5-0.4-0.30.4-0.4
Bone: trabecular spacing0.60.82.7-1.61.31.31.21.21.21.1-0.8-0.8-0.80.71.10.71.6-0.10.10.20.20.1-0.0-0.10.1
Bone: trabecular thickness0.40.52.10.9-0.6-0.5-0.4-0.4-0.4-0.3-0.1-0.1-0.10.3-0.60.3-1.5-0.70.70.81.00.71.1-0.70.7
Bone: trabecular tissue density1.32.02.8-1.51.51.51.51.51.51.5-1.4-1.4-1.41.41.61.41.7-1.31.31.31.31.31.2-1.31.3
Water consumed over 24 hours0.70.91.3-0.80.90.90.90.90.90.9-1.0-1.0-1.01.00.71.00.5-1.11.11.11.11.11.1-1.11.1
Number of responses in last shaping day1.61.72.81.0-1.1-1.1-1.1-1.1-1.1-1.21.31.31.3-1.3-1.3-1.4-0.91.7-1.7-1.5-1.6-1.3-1.61.4-1.4