Hub : Genes

Ap5b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ap5b1 0.03 0.02 8.9e-03 0 0 0 0 3.2e-01 9.6e-02 3.2e-01 1.5e-01
2 Brain gene expression Ap5b1 0.07 0.04 3.0e-07 0.08 0.07 0.06 0.07 8.1e-08 3.2e-07 2.2e-06 8.7e-07
3 OFC gene expression Ap5b1 0.18 0.1 3.0e-03 0.08 0.04 0.11 0.05 6.5e-03 3.3e-02 1.5e-03 2.1e-02
4 PL gene expression Ap5b1 0.11 0.06 3.1e-12 0.11 0.12 0.12 0.12 7.5e-12 5.3e-13 1.8e-12 1.6e-12
5 BLA gene expression Ap5b1 0.22 0.1 6.8e-10 0.15 0.16 0.15 0.15 1.8e-08 8.5e-09 2.6e-08 2.1e-08
6 NAcc gene expression Ap5b1 0.09 0.05 2.5e-12 0.08 0.09 0.08 0.09 2.0e-12 4.7e-13 8.4e-12 3.9e-13
7 IC gene expression Ap5b1 0.1 0.06 1.7e-03 0.03 0.05 0.02 0.02 3.2e-02 5.1e-03 6.4e-02 3.7e-02
8 pVTA gene expression Ap5b1 0.05 0.03 9.4e-04 0.02 0.03 0.03 0.03 1.6e-02 1.2e-03 2.8e-03 4.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.22.04.4-2.1-1.0-0.6-1.3-1.2-1.1-1.6-1.9
Area under the delay curve0.91.11.9-0.7-1.0-0.8-1.0-1.2-1.4-1.0-1.1
BMI with tail2.79.325.4-5.0-1.2-1.4-2.4-2.3-2.6-3.4-4.0
BMI without tail1.23.69.9-3.1-1.1-0.6-1.5-1.6-1.8-1.9-2.4
Body weight0.62.817.2-4.11.11.20.10.40.1-0.7-1.5
Weight adjusted by age0.91.31.9-0.61.41.31.31.31.30.90.7
Bone surface1.01.910.7-3.30.71.10.20.40.4-0.7-1.3
Bone volume0.71.36.0-2.5-0.10.1-0.5-0.4-0.3-1.2-1.6
Breakpoint value in progressive ratio session0.91.12.6-1.61.41.21.10.90.90.3-0.0
Number of licking bursts0.10.20.5-0.50.70.40.40.30.30.1-0.0
Context. condit. distance diff. score1.01.22.30.9-1.5-1.3-1.2-1.2-1.2-0.8-0.5
Locomotion velocity, session 10.10.10.30.30.10.40.30.40.30.50.6
Locomotion distance, session 10.91.22.8-1.7-0.8-0.4-1.0-0.9-1.0-1.0-1.3
Locomotion velocity, session 20.60.74.2-2.10.70.70.20.2-0.0-0.3-0.7
Locomotion distance, session 20.60.82.9-1.7-0.5-0.1-0.7-0.6-0.8-0.8-1.1
Locomotion velocity, session 31.21.31.7-0.8-0.7-1.3-1.3-1.1-1.3-1.2-1.2
Locomotion distance, session 30.00.00.00.00.1-0.2-0.2-0.1-0.2-0.1-0.1
Stereotopy head waving bouts, day 31.82.13.2-0.5-1.4-1.6-1.8-1.5-1.5-1.5-1.4
Stereotopy head waving duration, day 31.11.32.1-0.1-1.3-1.3-1.4-1.3-1.1-1.2-1.1
Locomotion velocity, session 72.83.03.9-1.1-1.5-1.8-1.7-1.8-2.0-1.9-1.9
Locomotion distance, session 70.70.91.2-0.8-0.8-0.9-1.0-1.0-1.1-0.9-1.0
Stereotopy head waving bouts, day 70.50.50.9-0.5-0.6-0.7-0.7-0.7-0.6-0.9-0.9
Stereotopy head waving duration, day 70.40.41.6-1.30.1-0.0-0.3-0.4-0.3-0.8-1.0
Locomotion velocity, session 80.70.81.5-0.40.91.20.81.01.01.00.8
Locomotion distance, session 80.91.31.6-0.5-1.2-1.2-1.2-1.1-1.2-1.2-1.1
Degree of sensitization distance0.90.91.1-1.0-1.0-0.9-1.0-0.9-0.9-1.0-1.1
Degree of sensitization stereotypy0.20.20.7-0.80.20.00.1-0.0-0.1-0.5-0.6
Conditioned locomotion0.60.71.4-0.90.91.20.91.00.70.60.4
Cocaine response after cond. corrected0.50.71.30.8-1.1-1.1-0.8-0.7-0.9-0.3-0.1
Cocaine response after cond. not corrected0.40.51.10.7-0.9-1.1-0.8-0.6-0.7-0.3-0.1
Cocaine response before conditioning0.30.41.0-0.61.00.50.60.60.70.20.1
Saline control response1.21.53.1-1.81.01.71.11.21.20.90.4
Bone: connectivity density1.01.57.6-2.8-0.30.3-0.6-0.5-0.4-1.0-1.6
Bone: cortical apparent density0.30.40.70.40.80.70.80.60.50.70.7
Bone: cortical area0.40.61.3-0.61.20.70.91.00.80.40.3
Bone: cortical porosity0.20.20.7-0.8-0.3-0.0-0.4-0.4-0.4-0.5-0.6
Bone: cortical porosity0.20.21.2-1.1-0.10.3-0.2-0.2-0.2-0.4-0.6
Bone: cortical thickness3.15.18.5-0.42.92.52.62.52.12.21.9
Bone: cortical thickness1.21.42.70.21.61.21.21.11.01.41.2
Bone: cortical tissue density0.50.61.00.30.90.91.00.70.70.90.8
Condit. Reinf. active minus inactive responses0.10.20.5-0.7-0.5-0.2-0.1-0.3-0.4-0.3-0.4
Condit. Reinf. active-inactive response ratio0.00.00.3-0.1-0.50.10.1-0.2-0.10.0-0.0
Condit. Reinf. active responses0.40.40.6-0.7-0.6-0.7-0.4-0.5-0.7-0.7-0.8
Condit. Reinf. inactive responses0.60.81.2-0.6-0.6-1.1-0.8-0.7-0.9-1.1-1.0
Incentive salience index mean0.50.61.6-1.2-0.6-0.5-0.5-0.6-0.8-0.8-1.0
Condit. Reinf. lever presses0.30.41.5-1.2-0.0-0.3-0.1-0.1-0.3-0.7-0.8
Condit. Reinf. active minus inactive responses0.10.10.2-0.1-0.5-0.4-0.3-0.3-0.1-0.5-0.4
Condit. Reinf. active-inactive response ratio0.50.61.50.1-0.7-1.2-0.8-0.6-0.5-1.0-0.8
Condit. Reinf. active responses0.20.20.6-0.7-0.5-0.1-0.4-0.5-0.2-0.5-0.7
Condit. Reinf. inactive responses0.20.31.2-1.1-0.20.4-0.3-0.5-0.2-0.2-0.5
Condit. Reinf. lever presses0.50.72.3-1.51.00.90.70.70.80.0-0.4
Condit. Reinf. lever reinforcers received0.10.10.7-0.8-0.10.3-0.0-0.10.2-0.3-0.5
Conditioned reinforcement - actives0.30.50.90.50.80.50.70.91.00.40.5
Conditioned reinforcement - inactives0.50.83.51.9-0.8-1.1-0.5-0.4-0.2-0.30.1
Conditioned locomotion1.72.28.83.0-1.6-1.9-1.0-1.0-0.7-0.40.3
Patch foraging indifference point 0 sec0.10.10.2-0.2-0.4-0.4-0.4-0.4-0.2-0.3-0.3
Patch foraging indifference point AUC1.31.93.0-0.81.61.71.61.51.51.00.7
Delay disc. indifference point, 0s delay2.02.23.9-0.6-1.7-1.2-1.6-1.7-2.0-1.4-1.4
Delay disc. indifference point, 16s delay0.90.91.40.1-1.0-1.2-1.0-1.2-1.1-1.0-0.9
Delay disc. indifference point, 2s delay0.50.50.7-0.2-0.6-0.8-0.8-0.7-0.8-0.8-0.7
Delay disc. indifference point, 24s delay0.00.10.10.4-0.10.10.1-0.0-0.10.30.4
Delay disc. indifference point, 4s delay0.91.01.7-0.5-1.1-0.8-1.1-1.2-1.3-0.8-0.9
Delay disc. indifference point, 8s delay0.50.51.0-0.4-0.8-0.4-0.8-0.9-1.0-0.6-0.6
Indifference point function ln k2.44.27.82.3-2.4-2.8-2.1-2.1-2.1-1.1-0.5
Indifference point function log k2.44.27.82.3-2.4-2.8-2.1-2.1-2.1-1.1-0.5
Patch foraging total patch changes 0 sec0.00.00.00.1-0.00.00.10.10.20.20.2
Patch foraging total patch changes 12 sec1.21.54.5-2.11.31.71.11.00.80.5-0.1
Patch foraging total patch changes 18 sec0.10.21.0-1.00.30.30.10.10.1-0.2-0.4
Patch foraging total patch changes 24 sec1.11.92.7-0.71.41.71.51.61.61.31.0
Patch foraging total patch changes 6 sec0.20.31.6-1.30.50.50.30.30.30.2-0.2
Patch foraging time to switch 0 sec1.12.37.8-2.8-0.2-0.3-0.9-0.9-1.2-1.7-2.1
Patch foraging water rate 0 sec1.12.412.13.5-0.5-0.40.40.50.81.31.9
Patch foraging water rate 12 sec1.63.318.34.3-1.4-1.0-0.4-0.20.11.11.9
Patch foraging water rate 18 sec0.60.94.32.1-1.0-1.0-0.6-0.4-0.30.30.7
Patch foraging water rate 24 sec1.11.58.62.9-0.8-0.7-0.20.00.20.71.3
Patch foraging water rate 6 sec1.21.79.13.0-0.7-0.6-0.10.20.31.11.6
Seeking ratio, delayed vs. immediate footshock0.91.01.5-0.6-1.0-1.1-1.0-1.2-1.1-1.1-1.1
Distance traveled before self-admin0.20.31.3-1.10.10.1-0.0-0.1-0.2-0.6-0.8
Distance traveled after self-admin0.10.10.3-0.30.40.50.50.30.50.20.1
Extensor digitorum longus weight2.18.220.7-4.53.73.52.62.62.01.20.1
Bone: elastic displacement1.11.33.51.90.30.30.80.90.81.41.6
Bone: elastic work1.01.41.9-0.11.21.31.31.31.11.41.2
Bone: endosteal estimation2.24.86.2-0.8-2.5-2.3-2.5-2.1-2.0-2.4-2.3
Bone: endosteal perimeter2.35.06.6-0.6-2.5-2.5-2.5-2.1-2.0-2.6-2.4
Epididymis fat weight1.03.66.32.3-2.4-2.5-1.9-1.6-1.5-1.5-0.7
Delta time in closed arm before/after self-admin0.10.10.2-0.3-0.00.4-0.00.10.00.40.3
Delta time in open arm before/after self-admin0.30.30.80.00.90.60.70.60.70.20.2
Diff in mean of infusions in LGA sessions0.40.50.8-0.30.80.90.80.80.80.70.5
Delay discount exponential model param0.70.71.30.60.80.60.81.01.10.80.9
Extinction: sum of active levers before priming0.60.74.1-2.00.50.30.20.0-0.1-0.5-0.9
Active lever presses in extinction session 61.61.62.8-1.11.71.51.31.51.40.70.4
Bone: final force0.61.03.1-1.81.11.20.80.90.80.2-0.2
Bone: final moment0.60.92.9-1.71.01.10.70.90.70.2-0.2
Food consumed during 24 hour testing period0.81.01.30.81.00.91.11.11.11.01.1
Glucose3.96.18.1-0.2-2.8-2.7-2.8-2.7-2.7-2.5-2.2
Heart weight4.16.38.7-1.0-2.9-2.4-2.9-2.7-2.7-2.5-2.4
Delay discount hyperbolic model param0.70.81.40.60.90.70.91.01.20.90.9
Intermittent access intake day 1-15 change0.20.42.61.6-0.3-0.50.10.20.30.20.5
Intermittent access intake escalation0.20.52.51.6-0.1-0.30.30.40.50.30.7
Intermittent access intake escalation 20.40.42.31.5-0.1-0.30.30.30.50.30.6
Intermitt. access day 1 inactive lever presses0.00.10.30.5-0.1-0.20.1-0.10.00.10.2
Intermitt. access day 15 inactive lever presses0.40.91.71.0-1.0-1.3-0.9-0.9-0.8-0.9-0.6
Intermitt. access escalation Index1.82.54.81.0-2.2-1.8-1.7-1.8-1.8-1.2-0.9
Intermittent access day 1 total infusions4.06.48.4-0.3-2.8-2.7-2.9-2.7-2.6-2.8-2.5
Intermittent access day 15 total infusions1.82.75.31.6-2.0-2.3-1.7-1.5-1.3-1.5-1.0
Intermittent access terminal intake (last 3 days)2.43.25.51.1-2.1-2.4-2.0-1.7-1.5-1.9-1.4
Intermittent access total infusions3.44.05.90.5-2.3-2.4-2.3-2.0-1.9-2.1-1.8
Intermittent access day 1 locomotion3.03.85.0-0.0-2.1-2.2-2.2-2.1-2.0-2.1-1.9
Intermittent access day 15 total locomotion1.52.75.11.3-1.9-2.2-1.7-1.5-1.4-1.6-1.2
Intermittent access total locomotion5.16.19.61.0-2.8-3.1-2.7-2.5-2.3-2.6-2.1
Intermittent access standard deviation0.20.42.31.5-0.6-0.5-0.2-0.10.00.10.4
Left kidney weight0.52.44.50.6-2.1-1.7-1.6-1.5-1.7-1.6-1.2
Right kidney weight0.10.31.11.0-0.5-0.7-0.4-0.3-0.4-0.30.0
Cocaine induced anxiety0.00.00.1-0.10.30.00.20.20.2-0.0-0.0
Post-drug Anxiety0.40.41.2-0.61.10.50.60.70.60.30.1
Baseline Anxiety0.30.40.7-0.20.80.70.50.60.60.70.5
Tail length0.72.64.30.11.32.11.81.71.71.81.6
Length with tail1.25.28.8-1.32.53.02.42.62.42.11.6
Length without tail1.54.87.6-1.02.82.72.22.42.32.11.6
Times rat made contact with spout0.10.10.5-0.7-0.10.60.1-0.1-0.10.1-0.1
Lifetime Intake2.83.44.60.2-2.1-2.2-2.2-1.9-1.8-1.9-1.7
Liver weight, left0.20.41.01.0-1.0-0.8-0.6-0.3-0.3-0.10.2
Liver weight, right0.71.32.31.4-1.5-1.4-1.3-1.0-1.0-0.4-0.0
Locomotor activity0.50.94.42.1-0.4-0.4-0.10.10.20.81.2
Locomotor testing distance0.61.15.62.4-0.7-0.3-0.2-0.00.00.91.3
Locomotor testing rearing0.51.03.51.9-1.5-0.5-0.8-0.7-0.40.40.6
Locomotion in novel chamber1.62.03.51.9-1.7-1.8-1.5-1.2-1.2-1.0-0.4
Locomotion in novel chamber post-restriction0.81.32.41.5-1.4-1.6-1.1-1.1-1.0-0.8-0.4
Fecal boli incidents, locomotor time 10.10.10.20.10.4-0.20.40.30.3-0.1-0.1
Change in fecal boli incidents, locomotor task0.30.30.6-0.5-0.5-0.4-0.8-0.6-0.5-0.4-0.5
Time >=10cm from walls, locomotor time 12.52.74.3-0.6-1.4-1.8-1.7-1.6-1.4-2.1-1.9
Bouts of movement, locomotor time 11.31.52.6-0.31.41.61.61.11.21.10.9
Total resting periods, locomotor time 10.70.81.6-0.31.01.21.30.80.90.70.6
Rest time, locomotor task time 10.20.31.91.4-0.4-0.5-0.2-0.1-0.10.00.4
Distance moved, locomotor task time 10.60.91.4-1.2-0.7-0.6-0.9-0.9-1.0-1.0-1.2
Vertical activity count, locomotor time 10.20.51.20.6-0.7-1.1-0.7-0.7-0.6-0.4-0.2
Time >=10cm from walls, locomotor time 20.00.00.1-0.20.10.20.20.10.0-0.3-0.2
Bouts of movement, locomotor time 20.10.20.3-0.60.50.60.50.20.30.20.0
Total resting periods, locomotor time 20.00.10.3-0.50.20.20.2-0.1-0.0-0.1-0.2
Rest time, locomotor task time 20.81.11.61.0-1.2-1.3-1.1-1.0-1.1-0.8-0.5
Distance moved, locomotor task time 20.70.91.5-0.51.11.21.11.00.80.90.6
Vertical activity count, locomotor time 21.11.52.51.11.20.81.21.21.21.51.6
Light reinforcement 10.00.10.40.6-0.00.20.10.10.30.40.4
Light reinforcement 20.10.21.01.0-0.0-0.6-0.10.00.1-0.20.0
Bone: marrow area2.45.26.8-0.8-2.6-2.4-2.6-2.2-2.2-2.5-2.4
Bone: maximum diameter0.10.20.4-0.30.50.20.40.70.6-0.0-0.0
Bone: maximum force0.81.48.1-2.80.70.70.20.30.1-0.7-1.2
Bone: maximum moment0.71.37.5-2.70.60.60.10.30.1-0.7-1.2
Mean time between licks in bursts0.10.30.6-0.20.70.70.40.50.50.80.6
Mean num. licks in bursts0.20.21.00.3-1.0-0.2-0.5-0.6-0.5-0.2-0.1
Cd content in liver0.30.40.80.9-0.7-0.8-0.5-0.6-0.4-0.5-0.3
Co content in liver1.01.24.42.10.10.40.70.50.51.31.6
Cu content in liver0.40.40.8-0.5-0.3-0.6-0.5-0.8-0.9-0.7-0.7
Fe content in liver0.30.40.60.10.60.50.50.80.80.70.6
K content in liver0.50.41.5-1.2-0.4-0.3-0.5-0.4-0.6-0.6-0.8
Mg content in liver0.80.81.3-0.2-1.1-0.9-1.0-1.0-1.0-0.8-0.7
Mn content in liver1.31.42.4-1.31.51.41.31.31.20.60.3
Na content in liver1.11.21.80.31.31.11.21.31.21.11.0
Rb content in liver1.31.53.00.7-1.7-1.3-1.4-1.4-1.2-0.8-0.6
Se content in liver0.10.10.10.2-0.3-0.4-0.2-0.1-0.0-0.3-0.2
Sr content in liver2.62.33.5-0.31.71.91.71.71.61.41.1
Zn content in liver0.10.10.4-0.6-0.10.20.0-0.1-0.2-0.1-0.2
Bone: minimum diameter3.15.77.0-1.1-2.6-2.4-2.5-2.4-2.5-2.7-2.6
Time in familiar zone, hab. session 10.70.61.2-0.2-0.8-1.1-0.8-0.8-0.8-0.8-0.8
Time in novel zone, hab. session 10.50.51.00.90.50.60.40.50.50.91.0
Total zone transitions, hab. session 10.10.21.1-1.10.30.30.20.0-0.1-0.2-0.4
Total locomotion distance, hab. session 10.81.11.4-0.3-1.1-1.1-1.0-1.0-1.2-1.1-1.0
Locomotion velocity, hab. session 10.40.60.8-0.6-0.8-0.7-0.7-0.7-0.9-0.9-0.9
Time in familiar zone, hab. session 20.30.30.60.50.40.30.30.50.50.80.8
Time in novel zone, hab. session 20.40.40.7-0.7-0.5-0.2-0.4-0.6-0.6-0.8-0.8
Total zone transitions, hab. session 21.92.57.2-2.7-0.7-0.4-1.4-1.3-1.3-1.6-2.1
Total locomotion distance, hab. session 22.12.83.7-1.5-1.4-1.3-1.8-1.7-1.8-1.8-1.9
Locomotion velocity, hab. session 22.33.14.1-1.4-1.5-1.5-1.9-1.8-1.8-2.0-2.0
Novel to familiar place preference ratio0.20.31.0-1.00.40.50.40.30.3-0.3-0.4
Novelty place preference0.10.10.5-0.70.10.20.20.00.1-0.4-0.5
Time in novel zone, NPP test0.10.10.4-0.6-0.00.20.1-0.00.1-0.3-0.4
Total zone transitions, NPP test0.60.84.8-2.20.30.80.0-0.0-0.1-0.5-0.9
Total locomotion distance, NPP test0.71.01.3-1.1-0.9-0.6-0.9-0.9-1.1-1.1-1.2
Locomotion velocity, NPP test0.60.81.3-1.1-0.7-0.5-0.7-0.8-1.0-1.0-1.1
Intraocular pressure0.60.93.82.00.00.10.60.70.90.71.1
Delta distance traveled before/after self-admin0.40.40.80.80.20.40.40.40.50.90.9
Delta ambulatory time before/after self-admin0.30.40.90.70.30.50.50.50.60.90.9
Parametrial fat weight2.35.39.01.2-2.6-3.0-2.5-2.4-2.3-2.3-1.7
Pavlov. Cond. lever latency0.20.20.90.90.00.10.20.20.30.50.6
Pavlov. Cond. magazine entry latency0.70.91.8-1.3-0.4-0.4-0.7-0.9-0.8-1.2-1.3
Pavlov. Cond. change in total contacts0.30.30.7-0.70.0-0.4-0.1-0.4-0.5-0.8-0.8
Pavlov. Cond. index score0.10.10.4-0.60.40.20.1-0.0-0.0-0.3-0.3
Pavlov. Cond. latency score0.10.20.5-0.70.1-0.1-0.2-0.3-0.3-0.5-0.6
Pavlov. Cond. lever contacts0.30.30.7-0.8-0.2-0.3-0.4-0.5-0.5-0.6-0.7
Pavlov. Cond. magazine entry number0.20.20.60.3-0.8-0.6-0.6-0.4-0.4-0.1-0.0
Pavlov. Cond. intertrial magazine entries0.20.21.11.0-0.0-0.20.30.20.20.40.5
Pavlov. Cond. lever-magazine prob. diff.0.10.20.8-0.90.30.10.1-0.1-0.2-0.4-0.6
Pavlov. Cond. response bias0.10.10.3-0.40.60.30.40.20.2-0.0-0.1
Pavlov. Cond. lever latency0.30.41.00.5-1.0-0.7-0.7-0.8-0.8-0.3-0.1
Pavlov. Cond. magazine entry latency1.01.25.4-2.31.31.20.70.50.4-0.1-0.6
Pavlov. Cond. change in total contacts0.40.62.3-1.50.90.60.60.40.4-0.3-0.7
Pavlov. Cond. index score0.60.83.2-1.81.10.90.70.60.5-0.1-0.5
Pavlov. Cond. latency score0.50.72.7-1.71.10.70.60.60.5-0.2-0.5
Pavlov. Cond. lever contacts0.30.40.9-0.61.00.70.70.70.70.20.1
Pavlov. Cond. magazine entry number1.82.36.82.6-1.8-1.9-1.3-1.1-1.0-0.30.3
Pavlov. Cond. intertrial magazine entries0.20.41.11.1-0.7-0.8-0.5-0.4-0.3-0.20.0
Pavlov. Cond. lever-magazine prob. diff.0.81.03.7-1.91.21.00.80.70.6-0.1-0.5
Pavlov. Cond. response bias0.60.82.4-1.51.21.00.70.70.60.0-0.3
Time in closed arm before self-admin0.30.40.7-0.0-0.5-0.8-0.7-0.6-0.6-0.9-0.7
Time in closed arm after self-admin0.30.30.60.1-0.6-0.8-0.6-0.5-0.5-0.4-0.3
Time in open arm before self-admin0.20.20.70.4-0.8-0.1-0.2-0.3-0.40.40.5
Time in open arm after self-admin0.20.20.50.20.40.70.40.40.30.60.5
Bone: periosteal estimation0.40.81.4-0.9-0.7-0.9-0.9-0.6-0.7-1.2-1.2
Bone: periosteal perimeter0.30.51.1-1.0-0.4-0.5-0.5-0.3-0.4-0.9-1.0
Bone: post-yield work6.69.717.0-3.6-2.1-2.3-2.7-2.8-2.9-3.8-4.1
Progressive ratio test 1 active lever presses0.10.20.40.2-0.6-0.4-0.5-0.3-0.3-0.4-0.4
Progressive ratio test 1 breakpoint0.10.10.30.2-0.5-0.3-0.4-0.3-0.2-0.4-0.3
Progressive ratio test 1 inactive lever presses0.00.00.10.3-0.1-0.00.0-0.10.0-0.00.0
Progressive ratio test 2 active lever presses0.91.11.91.0-1.3-1.4-1.1-0.9-0.7-1.0-0.6
Progressive ratio test 2 breakpoint0.80.91.71.1-1.2-1.3-1.0-0.8-0.6-0.9-0.5
Progressive ratio test 2 inactive lever presses2.33.76.52.1-2.3-2.5-2.0-1.9-1.6-1.6-1.0
Incentive Sensitization - Responses0.30.50.8-0.5-0.6-0.7-0.7-0.6-0.5-0.9-0.9
Incentive Sensitization - Breakpoint0.40.50.8-0.4-0.7-0.8-0.7-0.6-0.6-0.9-0.9
Sum of active levers in priming session hrs 5-65.45.07.50.92.51.92.62.72.72.02.0
Progressive ratio1.92.96.6-2.6-1.0-0.6-1.4-1.4-1.5-2.0-2.3
Food seeking constrained by brief footshock0.00.00.0-0.20.2-0.00.10.20.20.20.1
Seeking ratio, punishment vs. effort1.01.44.92.20.3-0.10.70.70.71.41.7
Retroperitoneal fat weight3.514.824.94.3-5.0-4.9-4.1-3.8-3.4-2.5-1.3
Reaction time number correct0.51.01.50.31.11.01.11.21.11.11.0
Reaction time mean minus median0.51.33.1-1.81.71.21.11.00.90.2-0.2
Reaction time mean minus median AUC0.51.32.7-0.81.71.31.31.21.10.60.4
Reaction time num false alarms0.10.20.50.7-0.2-0.4-0.1-0.1-0.40.40.5
Reaction time num false alarms AUC0.10.10.30.20.30.00.20.1-0.20.50.5
Reaction time trials correct on left0.51.01.50.31.11.01.11.21.11.11.0
Reaction time trials on left0.71.31.80.31.21.11.21.31.21.21.1
Reaction time mean0.00.00.2-0.20.40.10.20.00.1-0.2-0.2
Reaction time mean AUC0.00.10.2-0.30.3-0.20.0-0.2-0.1-0.4-0.4
Median of all reaction times0.10.10.20.1-0.2-0.4-0.3-0.5-0.4-0.5-0.4
Reaction time omissions0.60.92.5-1.21.61.11.00.90.70.40.1
Reaction time false alarm rate0.10.20.50.3-0.4-0.6-0.4-0.5-0.7-0.1-0.0
Reaction time premature initiation rate1.21.63.4-1.11.31.81.21.21.11.30.9
Reaction time premature initiations2.34.06.9-0.92.22.62.12.12.02.11.6
Std. dev. reaction times0.30.51.3-0.81.20.70.70.60.60.1-0.1
Reaction time trials completed0.71.31.80.31.21.11.21.31.21.21.1
Reaction time trials AUC0.50.91.30.31.00.91.01.11.01.01.0
Run reversals in cocaine runway, females1.51.52.5-1.6-0.8-0.8-1.1-1.2-1.4-1.2-1.4
Run reversals in cocaine runway, males1.61.62.71.60.90.61.11.31.21.41.6
Latency to leave start box in cocaine runway1.31.42.0-0.9-0.9-1.0-1.2-1.2-1.3-1.4-1.4
Latency to leave start box in cocaine runway, F0.70.81.4-0.6-0.7-0.6-0.8-1.0-1.2-1.0-1.0
Latency to leave start box in cocaine runway, M0.30.20.4-0.6-0.1-0.6-0.5-0.3-0.3-0.6-0.6
Std. dev. time between licks in bursts0.20.30.60.50.50.40.20.40.30.80.8
Total sessions with >9 infusions1.01.21.8-1.0-1.0-0.8-1.2-1.0-1.1-1.2-1.3
Short access day 1 total inactive lever presses1.11.42.80.9-1.3-1.7-1.3-1.2-1.1-0.9-0.6
Short access day 10 total inactive lever presses0.10.30.60.6-0.6-0.8-0.4-0.5-0.5-0.10.0
Short access day 1 total infusions2.33.04.2-0.0-2.0-1.9-2.0-1.8-1.8-1.8-1.6
Short access day 10 total infusions4.05.16.7-1.4-2.2-2.1-2.4-2.3-2.3-2.6-2.6
Short access total infusions2.32.93.8-0.9-1.8-1.7-1.9-1.7-1.7-1.9-1.8
Short access day 1 locomotion1.51.83.00.3-1.6-1.7-1.5-1.5-1.4-1.3-1.1
Short access day 10 total locomotion1.22.12.9-0.1-1.7-1.6-1.5-1.5-1.5-1.6-1.4
Short access total locomotion1.92.33.10.1-1.8-1.7-1.6-1.6-1.6-1.6-1.4
One hour access (0.3 mA shock)2.42.84.62.0-2.1-2.1-1.8-1.5-1.4-1.2-0.6
Compulsive drug intake1.82.23.7-0.31.51.91.51.41.31.81.5
One hour access (shock baseline)2.43.76.81.9-2.3-2.6-2.0-1.8-1.6-1.7-1.1
Social response proportion0.20.20.5-0.70.40.60.40.40.70.2-0.0
Social responses0.30.40.90.00.50.80.60.70.90.70.6
Social time0.50.71.20.00.81.10.80.91.00.90.8
Soleus weight1.33.77.42.7-2.5-2.5-1.8-1.7-1.6-1.0-0.3
Bone: stiffness0.71.16.1-2.50.50.6-0.00.10.0-0.8-1.2
Tibialis anterior weight5.217.631.5-3.35.65.14.54.74.03.12.1
Time to tail flick, vehicle, before self-admin0.40.40.8-0.9-0.6-0.3-0.5-0.4-0.5-0.7-0.8
Time to tail flick, vehicle, after self-admin1.62.13.9-2.0-1.0-0.6-1.3-1.3-1.6-1.5-1.8
Time to tail flick, test, before self-admin3.94.05.7-0.2-2.4-2.2-2.2-2.2-2.3-1.9-1.7
Time to tail flick, test, after self-admin0.10.10.30.10.30.30.40.50.50.30.3
Delta time to tail flick, vehicle, before/after SA0.40.41.2-1.1-0.2-0.0-0.6-0.5-0.6-0.6-0.8
Delta time to tail flick, test, before/after SA6.56.78.50.92.82.72.92.92.92.52.5
Tibia length0.92.64.6-0.52.11.71.92.02.01.00.8
Ambulatory time before self-admin0.20.31.0-1.00.1-0.1-0.1-0.2-0.2-0.7-0.8
Ambulatory time after self-admin0.30.30.5-0.1-0.7-0.6-0.5-0.7-0.5-0.7-0.7
Bone: tissue strength0.10.10.1-0.3-0.3-0.2-0.2-0.2-0.2-0.3-0.3
Total heroin consumption1.72.03.4-1.81.81.81.51.31.30.80.3
Bone: trabecular number0.81.34.0-2.0-0.5-0.2-0.8-0.8-0.6-1.3-1.6
Bone: trabecular spacing0.10.10.70.8-0.3-0.2-0.1-0.2-0.20.30.5
Bone: trabecular thickness1.01.21.6-0.4-0.9-1.2-1.3-1.3-1.2-1.2-1.2
Bone: trabecular tissue density0.91.36.12.5-1.1-1.4-0.5-0.6-0.6-0.20.5
Water consumed over 24 hours0.60.82.1-0.50.71.41.00.80.80.90.6
Number of responses in last shaping day0.10.10.20.40.20.30.20.20.30.50.5