Ap5b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Ap5b1	0.07	0.04	1.1e-06	0.05	0.04	0.03	0.04	2.2e-05	6.7e-05	4.1e-04	2.3e-04
2	BLA	gene expression	Ap5b1	0.2	0.09	5.8e-09	0.12	0.14	0.12	0.11	5.0e-07	8.6e-08	9.9e-07	1.2e-06
3	PL	gene expression	Ap5b1	0.13	0.07	5.1e-14	0.12	0.13	0.12	0.13	5.1e-13	2.8e-14	1.6e-13	7.6e-14
4	pVTA	gene expression	Ap5b1	0.08	0.06	6.5e-03	0.08	0.04	0.05	0.06	3.6e-04	5.1e-03	2.9e-03	2.0e-03
5	NAcc	gene expression	Ap5b1	0.11	0.06	3.0e-09	0.07	0.07	0.07	0.07	1.1e-08	4.3e-09	7.9e-09	1.5e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	1.0	1.7	2.2	0.9	-1.4	-1.5	1.3	-1.4
Area under the delay curve	1.1	1.2	2.2	1.0	-1.2	-1.0	-0.4	-1.5
BMI with tail	1.5	5.0	6.7	1.0	-2.2	-2.6	2.5	-2.5
BMI without tail	0.9	1.8	3.1	1.1	-1.3	-1.5	0.9	-1.8
Body weight	0.2	0.8	2.6	-1.6	0.9	0.5	-0.3	0.4
Weight adjusted by age	1.4	1.6	2.0	-1.4	1.3	1.2	-1.0	1.3
Bone surface	0.1	0.3	0.9	-1.0	0.2	-0.1	0.4	0.4
Bone volume	0.2	0.4	1.0	-0.1	-0.6	-0.7	1.0	-0.2
Breakpoint value in progressive ratio session	1.4	1.6	2.6	-1.6	1.1	1.1	-1.2	1.2
Number of licking bursts	0.1	0.1	0.2	-0.5	0.2	0.3	-0.2	0.3
Context. condit. distance diff. score	1.4	1.7	3.5	1.9	-1.2	-1.1	1.1	-1.1
Locomotion velocity, session 1	0.1	0.1	0.2	-0.1	0.4	0.3	-0.4	0.1
Locomotion distance, session 1	0.6	0.8	1.6	0.7	-0.9	-1.0	0.1	-1.3
Locomotion velocity, session 2	0.2	0.2	0.5	-0.7	0.3	0.1	-0.6	-0.1
Locomotion distance, session 2	0.3	0.4	1.1	0.1	-0.5	-0.6	-0.3	-1.0
Locomotion velocity, session 3	1.3	1.6	2.4	0.8	-1.2	-1.4	1.6	-1.2
Locomotion distance, session 3	0.0	0.0	0.1	0.1	-0.2	-0.2	0.2	-0.2
Stereotopy head waving bouts, day 3	2.1	2.5	3.2	1.4	-1.5	-1.7	1.8	-1.6
Stereotopy head waving duration, day 3	1.4	1.6	1.9	1.3	-1.2	-1.3	1.4	-1.2
Locomotion velocity, session 7	2.9	3.2	3.9	1.5	-2.0	-2.0	1.7	-1.8
Locomotion distance, session 7	0.8	1.0	1.7	0.7	-1.1	-1.2	0.5	-1.3
Stereotopy head waving bouts, day 7	0.6	0.7	1.5	0.6	-0.8	-0.7	1.2	-0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.2	-0.1	-0.4	-0.3	0.4	-0.3
Locomotion velocity, session 8	0.6	0.7	1.1	-1.0	1.1	0.8	-0.7	0.6
Locomotion distance, session 8	1.0	1.4	1.8	1.2	-1.1	-1.3	1.3	-1.0
Degree of sensitization distance	0.9	0.9	1.3	0.7	-1.0	-1.1	1.0	-1.0
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.4	-0.1	0.0	0.5	0.2
Conditioned locomotion	0.7	0.8	1.2	-0.9	1.1	1.0	-0.5	0.9
Cocaine response after cond. corrected	0.8	0.9	1.2	1.1	-0.8	-0.9	0.8	-1.0
Cocaine response after cond. not corrected	0.7	0.8	0.9	1.0	-0.8	-0.9	0.8	-1.0
Cocaine response before conditioning	0.3	0.4	0.7	-0.9	0.5	0.5	-0.5	0.6
Saline control response	1.1	1.4	2.4	-1.5	1.2	0.9	-1.4	0.6
Bone: connectivity density	0.2	0.4	0.6	0.1	-0.6	-0.8	0.5	-0.8
Bone: cortical apparent density	0.5	0.6	2.3	-0.5	0.5	0.7	-1.5	0.1
Bone: cortical area	0.6	0.9	1.5	-1.2	0.9	0.8	0.2	1.2
Bone: cortical porosity	0.5	0.5	0.8	0.9	-0.7	-0.7	0.5	-0.8
Bone: cortical porosity	0.1	0.1	0.2	0.4	-0.2	-0.3	0.1	-0.5
Bone: cortical thickness	3.1	5.0	6.0	-2.4	2.3	2.3	-2.2	1.9
Bone: cortical thickness	1.6	1.8	2.7	-1.5	1.3	1.3	-1.6	0.8
Bone: cortical tissue density	0.6	0.8	2.7	-0.7	0.6	0.8	-1.7	0.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.1	-0.2	-0.2	-0.3	-0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.1	-0.0	0.2	-0.6	-0.2
Condit. Reinf. active responses	0.1	0.2	0.2	0.3	-0.5	-0.5	0.3	-0.3
Condit. Reinf. inactive responses	0.6	0.7	1.6	0.6	-0.8	-0.9	1.3	-0.4
Incentive salience index mean	0.2	0.2	0.4	0.3	-0.5	-0.6	0.2	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.6	0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	0.3	-0.5	-0.5	0.7	-0.1
Condit. Reinf. active-inactive response ratio	1.0	1.1	3.7	0.6	-0.8	-0.9	1.9	0.0
Condit. Reinf. active responses	0.2	0.3	0.4	0.5	-0.7	-0.6	-0.0	-0.6
Condit. Reinf. inactive responses	0.6	0.7	1.5	0.6	-0.5	-0.4	-1.2	-1.2
Condit. Reinf. lever presses	0.5	0.7	1.5	-1.2	0.7	0.6	-0.2	1.0
Condit. Reinf. lever reinforcers received	0.0	0.1	0.1	0.2	-0.3	-0.2	-0.3	-0.3
Conditioned reinforcement - actives	0.2	0.2	0.8	-0.1	0.3	0.3	-0.3	0.9
Conditioned reinforcement - inactives	0.7	0.8	2.3	1.5	-1.0	-0.7	0.5	-0.0
Conditioned locomotion	0.6	0.7	2.4	1.5	-0.8	-0.6	0.4	0.0
Patch foraging indifference point 0 sec	0.1	0.1	0.1	0.3	-0.3	-0.3	0.1	-0.3
Patch foraging indifference point AUC	2.1	2.4	4.1	-2.0	1.4	1.4	-1.3	1.4
Delay disc. indifference point, 0s delay	2.0	2.1	3.7	1.6	-1.5	-1.5	-0.1	-1.9
Delay disc. indifference point, 16s delay	1.0	1.1	1.6	1.1	-1.3	-1.0	0.4	-1.1
Delay disc. indifference point, 2s delay	0.3	0.4	0.6	0.5	-0.6	-0.6	0.8	-0.5
Delay disc. indifference point, 24s delay	0.3	0.3	1.1	0.2	0.0	0.1	-1.1	-0.4
Delay disc. indifference point, 4s delay	1.1	1.1	2.3	1.0	-1.0	-1.0	-0.6	-1.5
Delay disc. indifference point, 8s delay	0.8	0.8	1.6	0.8	-0.8	-0.7	-0.8	-1.2
Indifference point function ln k	3.4	4.8	8.0	2.8	-2.0	-2.0	2.0	-2.0
Indifference point function log k	3.4	4.8	8.0	2.8	-2.0	-2.0	2.0	-2.0
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.0	0.1	0.1	-0.3	-0.0
Patch foraging total patch changes 12 sec	1.2	1.5	2.7	-1.6	1.0	1.0	-1.6	0.7
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.2	0.0
Patch foraging total patch changes 24 sec	1.9	2.3	3.1	-1.8	1.5	1.4	-1.6	1.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.8	0.2	0.1	-0.5	-0.1
Patch foraging time to switch 0 sec	0.4	0.6	0.9	0.4	-0.9	-0.9	0.8	-0.7
Patch foraging water rate 0 sec	0.2	0.3	0.6	0.3	0.4	0.5	0.4	0.8
Patch foraging water rate 12 sec	0.3	0.4	1.6	1.3	-0.1	-0.1	0.7	-0.2
Patch foraging water rate 18 sec	0.4	0.5	1.3	1.1	-0.5	-0.6	0.6	-0.6
Patch foraging water rate 24 sec	0.2	0.3	0.8	0.9	-0.0	-0.1	0.8	0.1
Patch foraging water rate 6 sec	0.1	0.1	0.2	0.5	0.1	0.0	0.5	-0.0
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.2	0.7	-0.9	-0.8	0.3	-1.1
Distance traveled before self-admin	0.2	0.2	0.4	-0.5	0.4	0.4	-0.2	0.6
Distance traveled after self-admin	0.2	0.2	0.3	-0.5	0.4	0.5	-0.1	0.6
Extensor digitorum longus weight	1.5	5.7	11.0	-3.3	2.4	2.1	-2.1	1.7
Bone: elastic displacement	0.3	0.3	0.5	-0.2	0.7	0.7	-0.5	0.5
Bone: elastic work	1.0	1.4	1.7	-1.2	1.3	1.2	-1.3	0.7
Bone: endosteal estimation	2.6	5.7	11.1	2.0	-2.2	-2.5	3.3	-1.6
Bone: endosteal perimeter	2.9	6.1	12.8	2.2	-2.2	-2.4	3.6	-1.4
Epididymis fat weight	1.8	4.2	6.3	2.2	-2.0	-2.0	2.5	-1.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.2	0.1	-0.1	-0.8	-0.5
Delta time in open arm before/after self-admin	0.5	0.5	0.9	-0.8	0.5	0.7	-0.3	1.0
Diff in mean of infusions in LGA sessions	1.2	1.3	2.6	-1.1	1.0	1.0	-1.6	1.0
Delay discount exponential model param	0.8	0.9	1.6	-0.9	1.0	0.9	0.5	1.3
Extinction: sum of active levers before priming	0.5	0.5	1.0	-1.0	0.4	0.5	-0.9	0.3
Active lever presses in extinction session 6	3.6	3.5	4.7	-2.1	1.9	1.8	-1.3	2.2
Bone: final force	0.4	0.7	1.4	-1.2	0.9	0.7	-0.2	0.9
Bone: final moment	0.4	0.6	1.3	-1.1	0.8	0.6	-0.2	0.8
Food consumed during 24 hour testing period	0.9	1.0	1.5	-1.0	1.0	1.1	-0.8	1.2
Glucose	3.4	5.1	5.7	2.4	-2.3	-2.4	2.2	-2.0
Heart weight	1.9	2.7	3.1	1.7	-1.8	-1.7	1.1	-1.7
Delay discount hyperbolic model param	0.7	0.7	1.4	-0.8	0.9	0.8	0.5	1.2
Intermittent access intake day 1-15 change	0.6	0.6	1.5	-0.2	0.7	0.8	-0.4	1.2
Intermittent access intake escalation	0.2	0.2	0.6	0.1	0.3	0.4	-0.1	0.8
Intermittent access intake escalation 2	0.8	0.8	1.7	-0.5	0.9	1.0	-0.6	1.3
Intermitt. access day 1 inactive lever presses	0.6	0.6	1.4	1.2	-1.0	-0.8	-0.0	-0.5
Intermitt. access day 15 inactive lever presses	0.4	0.4	1.0	1.0	-0.7	-0.5	0.3	0.1
Intermitt. access escalation Index	4.9	4.3	4.9	2.2	-2.0	-2.0	2.0	-2.2
Intermittent access day 1 total infusions	8.4	9.8	11.9	3.4	-3.3	-3.3	2.8	-2.7
Intermittent access day 15 total infusions	3.8	4.2	7.0	2.6	-2.1	-2.1	2.0	-1.1
Intermittent access terminal intake (last 3 days)	3.9	4.2	6.1	2.4	-2.0	-2.1	2.5	-1.0
Intermittent access total infusions	5.3	5.9	7.8	2.8	-2.5	-2.5	2.5	-1.7
Intermittent access day 1 locomotion	7.4	7.8	9.7	3.1	-3.0	-3.1	1.7	-2.8
Intermittent access day 15 total locomotion	2.3	2.5	4.8	2.2	-1.8	-1.7	0.6	-1.0
Intermittent access total locomotion	7.4	8.4	11.5	3.4	-3.1	-3.1	2.5	-2.2
Intermittent access standard deviation	0.1	0.1	0.3	0.6	-0.0	0.0	-0.3	0.4
Left kidney weight	0.2	0.7	2.0	0.9	-0.6	-0.4	1.4	0.1
Right kidney weight	0.2	0.7	2.1	-0.5	0.6	0.7	0.6	1.4
Cocaine induced anxiety	0.2	0.2	0.4	-0.3	0.3	0.3	0.5	0.6
Post-drug Anxiety	2.2	2.4	3.8	-1.9	1.5	1.4	-0.8	1.9
Baseline Anxiety	2.6	2.8	5.1	-1.8	1.5	1.3	-2.3	1.2
Tail length	1.8	5.4	6.4	-2.0	2.5	2.5	-2.5	2.0
Length with tail	2.1	7.7	9.3	-3.1	3.0	2.7	-2.5	2.6
Length without tail	1.4	3.0	5.8	-2.4	1.8	1.5	-1.1	1.6
Times rat made contact with spout	0.3	0.4	1.5	0.1	-0.0	0.1	-1.2	-0.6
Lifetime Intake	5.5	6.3	8.2	2.9	-2.6	-2.7	2.4	-1.9
Liver weight, left	0.1	0.2	0.7	0.2	-0.2	-0.2	0.9	-0.0
Liver weight, right	0.1	0.2	0.9	0.2	-0.1	-0.4	1.0	-0.2
Locomotor activity	0.0	0.1	0.2	0.3	0.2	0.1	-0.5	-0.0
Locomotor testing distance	0.1	0.1	0.3	0.5	0.1	-0.0	-0.5	-0.4
Locomotor testing rearing	0.5	0.7	1.6	1.3	-0.5	-0.6	-0.6	-1.1
Locomotion in novel chamber	1.3	1.6	3.1	1.6	-1.1	-1.0	1.8	-0.1
Locomotion in novel chamber post-restriction	0.9	1.1	1.8	1.3	-1.0	-0.9	1.3	-0.5
Fecal boli incidents, locomotor time 1	0.3	0.3	0.9	-0.5	0.2	0.3	0.5	1.0
Change in fecal boli incidents, locomotor task	0.6	0.5	1.4	0.6	-0.6	-0.8	-0.2	-1.2
Time >=10cm from walls, locomotor time 1	2.8	2.8	3.7	1.6	-1.8	-1.9	1.9	-1.0
Bouts of movement, locomotor time 1	2.1	2.3	5.6	-1.3	1.1	1.5	-2.4	0.8
Total resting periods, locomotor time 1	1.2	1.3	3.4	-1.0	0.8	1.1	-1.8	0.7
Rest time, locomotor task time 1	0.0	0.0	0.1	0.3	0.0	0.0	0.1	0.3
Distance moved, locomotor task time 1	0.6	0.7	0.8	0.5	-0.8	-0.9	0.9	-0.9
Vertical activity count, locomotor time 1	0.4	0.4	0.5	0.7	-0.7	-0.6	0.7	-0.5
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.0	-0.1	0.0	-0.1	0.2
Bouts of movement, locomotor time 2	0.4	0.5	1.6	-0.5	0.3	0.6	-1.3	0.1
Total resting periods, locomotor time 2	0.2	0.2	1.0	-0.2	-0.0	0.3	-1.0	-0.1
Rest time, locomotor task time 2	1.0	1.1	1.8	1.3	-1.1	-1.1	0.7	-0.8
Distance moved, locomotor task time 2	0.7	0.8	1.3	-1.1	0.9	1.0	-0.6	0.7
Vertical activity count, locomotor time 2	1.0	1.1	1.6	-1.1	1.3	1.1	-0.6	1.0
Light reinforcement 1	0.1	0.1	0.6	0.0	0.2	0.2	-0.8	0.0
Light reinforcement 2	0.3	0.4	1.4	0.2	-0.1	-0.0	1.2	0.8
Bone: marrow area	2.8	6.1	11.1	2.1	-2.3	-2.5	3.3	-1.7
Bone: maximum diameter	0.4	0.8	1.6	-0.7	0.6	0.4	1.1	1.3
Bone: maximum force	0.1	0.2	0.4	-0.6	0.1	-0.2	0.7	0.2
Bone: maximum moment	0.1	0.2	0.5	-0.6	0.0	-0.2	0.7	0.1
Mean time between licks in bursts	0.4	0.6	1.4	-0.7	0.8	0.5	-1.2	-0.0
Mean num. licks in bursts	0.3	0.3	0.6	0.7	-0.4	-0.4	-0.4	-0.8
Cd content in liver	0.2	0.2	0.7	0.1	0.2	0.3	0.6	0.8
Co content in liver	0.5	0.5	2.1	-0.0	0.4	0.6	-1.5	-0.0
Cu content in liver	0.1	0.1	0.3	-0.1	-0.2	-0.0	-0.6	-0.3
Fe content in liver	0.3	0.3	0.8	-0.9	0.5	0.4	0.1	0.7
K content in liver	0.3	0.3	0.5	0.2	-0.5	-0.7	0.6	-0.7
Mg content in liver	2.4	2.4	3.6	1.3	-1.7	-1.7	1.0	-1.9
Mn content in liver	0.9	1.0	1.9	-1.4	1.0	0.9	-0.6	1.1
Na content in liver	1.2	1.3	2.0	-1.3	1.2	1.1	-0.1	1.4
Rb content in liver	2.3	2.8	3.6	1.7	-1.9	-1.7	1.1	-1.9
Se content in liver	0.2	0.2	0.6	0.2	-0.3	-0.3	0.8	0.2
Sr content in liver	4.4	4.0	4.8	-2.2	2.0	2.1	-1.7	1.9
Zn content in liver	0.2	0.2	0.6	-0.7	0.2	0.3	-0.8	0.0
Bone: minimum diameter	3.3	6.2	8.1	2.3	-2.5	-2.6	2.8	-2.1
Time in familiar zone, hab. session 1	0.7	0.7	0.8	0.7	-0.8	-0.9	0.9	-0.7
Time in novel zone, hab. session 1	0.3	0.3	0.8	-0.3	0.5	0.5	-0.9	0.2
Total zone transitions, hab. session 1	0.1	0.1	0.4	-0.3	0.1	0.2	-0.7	-0.0
Total locomotion distance, hab. session 1	0.7	1.0	1.2	1.0	-1.1	-1.1	0.9	-0.9
Locomotion velocity, hab. session 1	0.3	0.5	0.5	0.6	-0.7	-0.7	0.7	-0.6
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.2	0.5	0.3	-0.2	0.1
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.4	-0.6	-0.4	-0.2	-0.5
Total zone transitions, hab. session 2	1.1	1.5	3.0	0.9	-1.3	-1.4	0.2	-1.7
Total locomotion distance, hab. session 2	2.0	2.6	3.6	1.4	-1.7	-1.8	1.1	-1.9
Locomotion velocity, hab. session 2	2.2	3.0	3.7	1.5	-1.8	-1.9	1.5	-1.8
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.7	0.2	0.3	-0.4	0.6
Novelty place preference	0.1	0.1	0.2	-0.4	-0.0	0.1	-0.3	0.3
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.2	0.2
Total zone transitions, NPP test	0.1	0.1	0.4	-0.1	0.1	-0.0	-0.7	-0.2
Total locomotion distance, NPP test	0.5	0.6	0.9	0.6	-0.9	-0.9	0.4	-1.0
Locomotion velocity, NPP test	0.3	0.4	0.6	0.5	-0.8	-0.7	0.2	-0.8
Intraocular pressure	0.5	0.7	1.9	-0.5	0.7	0.8	-0.5	1.4
Delta distance traveled before/after self-admin	0.0	0.0	0.0	-0.2	0.2	0.1	-0.2	-0.0
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.3	0.3	0.2	-0.5	-0.1
Parametrial fat weight	3.4	6.6	8.5	2.5	-2.7	-2.6	2.9	-2.1
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.1	0.2	0.3	-0.3	0.2
Pavlov. Cond. magazine entry latency	0.5	0.6	0.9	0.6	-1.0	-0.8	0.3	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.0	-0.5	-0.3	0.3	-0.1
Pavlov. Cond. index score	0.0	0.0	0.1	-0.3	-0.0	0.0	-0.1	0.1
Pavlov. Cond. latency score	0.0	0.1	0.1	0.0	-0.3	-0.3	0.2	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.0	-0.3	-0.3	0.3	-0.3
Pavlov. Cond. magazine entry number	0.3	0.3	0.5	0.7	-0.4	-0.6	0.5	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.1	0.2	0.4	0.1	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.2	-0.4	-0.0	0.1	-0.1	0.1
Pavlov. Cond. response bias	0.1	0.1	0.2	-0.5	0.1	0.3	-0.2	0.3
Pavlov. Cond. lever latency	0.2	0.2	0.4	0.6	-0.3	-0.3	-0.3	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	1.3	-1.1	0.5	0.5	-0.9	0.2
Pavlov. Cond. change in total contacts	0.3	0.4	1.0	-1.0	0.3	0.4	-0.1	0.8
Pavlov. Cond. index score	0.3	0.4	1.1	-1.1	0.5	0.5	-0.2	0.7
Pavlov. Cond. latency score	0.3	0.3	0.9	-1.0	0.4	0.4	0.0	0.7
Pavlov. Cond. lever contacts	0.6	0.8	1.4	-1.1	0.9	0.8	-0.2	1.2
Pavlov. Cond. magazine entry number	1.2	1.5	3.2	1.8	-1.0	-1.0	1.3	-0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	1.0	-0.5	-0.6	0.8	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	-1.1	0.6	0.6	-0.4	0.7
Pavlov. Cond. response bias	0.7	0.9	1.8	-1.4	0.8	0.8	-0.5	1.0
Time in closed arm before self-admin	0.1	0.1	0.4	-0.3	-0.2	-0.1	0.6	0.2
Time in closed arm after self-admin	0.2	0.2	0.3	0.3	-0.4	-0.5	0.2	-0.5
Time in open arm before self-admin	0.7	0.8	1.8	1.1	-0.6	-0.5	-0.5	-1.3
Time in open arm after self-admin	0.2	0.2	0.4	-0.3	0.4	0.6	-0.7	0.3
Bone: periosteal estimation	0.6	1.3	5.0	0.3	-0.7	-0.9	2.2	-0.0
Bone: periosteal perimeter	0.3	0.5	2.0	0.1	-0.3	-0.5	1.4	0.1
Bone: post-yield work	5.3	7.2	9.8	2.0	-2.9	-3.0	3.1	-2.2
Progressive ratio test 1 active lever presses	1.5	1.5	2.8	1.7	-1.2	-1.1	1.3	-0.8
Progressive ratio test 1 breakpoint	1.1	1.2	2.1	1.5	-0.9	-0.9	1.3	-0.5
Progressive ratio test 1 inactive lever presses	0.9	0.9	1.8	1.4	-1.0	-0.9	0.2	-1.0
Progressive ratio test 2 active lever presses	2.1	2.2	4.0	2.0	-1.4	-1.4	1.7	-0.6
Progressive ratio test 2 breakpoint	1.5	1.7	3.5	1.9	-1.2	-1.1	1.5	-0.4
Progressive ratio test 2 inactive lever presses	3.9	4.5	8.2	2.9	-2.4	-2.1	1.5	-1.4
Incentive Sensitization - Responses	0.4	0.4	0.8	0.9	-0.6	-0.6	0.7	-0.1
Incentive Sensitization - Breakpoint	0.4	0.4	0.9	0.9	-0.6	-0.6	0.8	-0.1
Sum of active levers in priming session hrs 5-6	5.6	5.5	9.3	-2.3	2.3	2.3	-1.2	3.1
Progressive ratio	0.7	0.8	1.3	0.4	-1.0	-1.1	0.3	-1.1
Food seeking constrained by brief footshock	0.2	0.2	0.4	-0.5	0.4	0.3	-0.7	0.0
Seeking ratio, punishment vs. effort	0.2	0.2	0.5	-0.1	0.7	0.7	-0.4	0.4
Retroperitoneal fat weight	3.4	11.3	19.3	3.5	-3.2	-3.1	4.4	-2.2
Reaction time number correct	0.7	1.0	1.4	-0.9	1.2	1.1	-0.8	1.1
Reaction time mean minus median	1.1	1.4	3.3	-1.8	0.9	0.9	-0.8	1.2
Reaction time mean minus median AUC	1.4	1.8	3.4	-1.9	1.2	1.2	-0.9	1.4
Reaction time num false alarms	0.0	0.1	0.2	-0.2	0.1	-0.0	-0.4	-0.4
Reaction time num false alarms AUC	0.2	0.3	0.9	-0.6	0.4	0.3	-0.9	-0.2
Reaction time trials correct on left	0.7	1.0	1.4	-0.9	1.2	1.1	-0.8	1.1
Reaction time trials on left	0.9	1.3	1.7	-1.1	1.3	1.2	-0.9	1.2
Reaction time mean	0.1	0.2	0.3	-0.6	0.1	0.3	-0.3	0.5
Reaction time mean AUC	0.1	0.1	0.1	-0.4	-0.1	0.1	-0.3	0.3
Median of all reaction times	0.0	0.0	0.1	0.0	-0.3	-0.1	-0.1	0.1
Reaction time omissions	0.9	1.3	2.4	-1.4	0.8	0.9	-1.6	0.7
Reaction time false alarm rate	0.1	0.1	0.4	-0.0	-0.3	-0.4	-0.1	-0.7
Reaction time premature initiation rate	1.4	1.9	3.3	-1.8	1.5	1.3	-1.3	0.6
Reaction time premature initiations	3.3	4.6	6.1	-2.5	2.4	2.2	-2.2	1.4
Std. dev. reaction times	0.6	0.8	1.8	-1.4	0.6	0.7	-0.7	0.9
Reaction time trials completed	0.9	1.3	1.7	-1.1	1.3	1.2	-0.9	1.2
Reaction time trials AUC	0.6	0.8	1.2	-0.8	1.1	0.9	-0.6	0.9
Run reversals in cocaine runway, females	1.7	1.6	3.4	0.9	-1.3	-1.4	0.5	-1.9
Run reversals in cocaine runway, males	1.2	1.1	2.0	-0.9	1.3	1.2	-0.1	1.4
Latency to leave start box in cocaine runway	1.0	1.1	1.5	0.8	-1.1	-1.1	1.2	-1.0
Latency to leave start box in cocaine runway, F	0.4	0.4	0.6	0.5	-0.8	-0.6	0.6	-0.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.8	0.1	-0.2	-0.5	0.9	-0.0
Std. dev. time between licks in bursts	0.1	0.1	0.3	-0.3	0.5	0.3	-0.5	-0.1
Total sessions with >9 infusions	3.1	3.5	4.1	2.0	-1.8	-2.0	1.8	-1.6
Short access day 1 total inactive lever presses	2.0	2.3	3.5	1.9	-1.7	-1.6	0.5	-1.4
Short access day 10 total inactive lever presses	1.0	1.1	2.2	1.5	-1.1	-1.0	-0.3	-1.1
Short access day 1 total infusions	6.4	6.9	8.9	3.0	-2.6	-2.6	2.4	-2.4
Short access day 10 total infusions	7.0	7.8	9.4	2.9	-3.0	-3.1	2.4	-2.6
Short access total infusions	4.5	5.0	5.9	2.4	-2.3	-2.4	2.0	-2.1
Short access day 1 locomotion	4.6	4.9	6.6	2.6	-2.3	-2.4	1.5	-2.1
Short access day 10 total locomotion	4.0	4.4	6.0	2.4	-2.2	-2.2	1.4	-2.1
Short access total locomotion	4.0	4.1	5.6	2.4	-2.1	-2.2	1.1	-2.1
One hour access (0.3 mA shock)	3.5	4.1	7.6	2.8	-2.0	-1.9	2.1	-1.0
Compulsive drug intake	1.7	1.7	2.5	-1.6	1.5	1.5	-1.1	0.5
One hour access (shock baseline)	2.9	3.4	6.2	2.5	-1.9	-1.7	1.9	-0.5
Social response proportion	0.2	0.2	0.4	-0.5	0.4	0.4	-0.6	0.4
Social responses	0.4	0.6	1.0	-0.7	0.7	0.6	-1.0	0.6
Social time	0.6	0.8	1.0	-1.0	0.9	0.8	-1.0	0.6
Soleus weight	1.4	4.1	6.3	2.5	-1.8	-1.7	2.5	-1.2
Bone: stiffness	0.0	0.1	0.2	-0.2	-0.2	-0.3	0.5	0.0
Tibialis anterior weight	5.5	18.9	31.3	-5.6	4.5	4.1	-3.0	4.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.1	-0.3	-0.4	-0.0	-0.2
Time to tail flick, vehicle, after self-admin	0.2	0.3	0.7	0.1	-0.4	-0.6	0.2	-0.9
Time to tail flick, test, before self-admin	3.4	3.3	3.9	1.9	-1.8	-1.9	1.3	-2.0
Time to tail flick, test, after self-admin	0.1	0.1	0.1	-0.4	0.4	0.4	-0.3	0.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	0.1	-0.2	-0.3	0.1	-0.6
Delta time to tail flick, test, before/after SA	6.0	5.4	6.2	-2.4	2.4	2.5	-1.9	2.4
Tibia length	1.4	4.0	7.7	-2.2	1.9	1.9	-0.2	2.8
Ambulatory time before self-admin	0.3	0.3	0.7	-0.5	0.4	0.4	0.2	0.8
Ambulatory time after self-admin	0.2	0.2	0.4	0.4	-0.6	-0.4	0.6	-0.1
Bone: tissue strength	0.0	0.0	0.0	0.1	-0.1	-0.1	0.2	0.1
Total heroin consumption	2.0	2.3	3.9	-2.0	1.4	1.4	-1.5	1.1
Bone: trabecular number	0.5	0.7	1.2	0.3	-0.9	-1.0	1.1	-0.7
Bone: trabecular spacing	0.1	0.1	0.5	0.2	0.0	0.1	-0.7	-0.3
Bone: trabecular thickness	1.3	1.6	2.0	1.2	-1.4	-1.3	1.1	-1.2
Bone: trabecular tissue density	0.5	0.7	1.8	1.3	-0.6	-0.5	1.0	-0.1
Water consumed over 24 hours	0.9	1.1	3.4	-0.8	0.8	0.9	-1.8	0.3
Number of responses in last shaping day	0.2	0.2	0.5	0.7	-0.3	-0.3	-0.2	-0.4