Hub : Genes

Ap3d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Eye mRNA stability Ap3d1 0.24 0.17 8.3e-03 0.1 0.04 0.05 0.05 1.4e-02 7.3e-02 5.5e-02 5.8e-02
2 NAcc gene expression Ap3d1 0.08 0.09 3.3e-04 0.03 0.02 0.03 0.03 6.5e-05 7.9e-04 6.1e-04 9.5e-05
3 Liver gene expression Ap3d1 0.09 0.06 3.2e-10 0.07 0.09 0.08 0.08 1.9e-08 1.1e-09 2.7e-09 2.1e-09
4 pVTA mRNA stability Ap3d1 0.07 0.06 2.5e-03 0.02 0.04 -0 0.02 4.9e-02 8.7e-03 6.4e-01 3.0e-02
5 NAcc mRNA stability Ap3d1 0.08 0.05 2.2e-13 0.12 0.12 0.12 0.11 5.5e-14 1.9e-13 2.7e-13 4.3e-13
6 Liver intron excision ratio chr7_8999998_9000364 0.03 0.03 1.3e-04 0.03 0.03 0.03 0.03 1.7e-04 2.0e-04 2.4e-04 2.2e-04
7 Adipose gene expression Ap3d1 0.18 0.11 0.0e+00 0.18 0.17 0.17 0.18 1.4e-19 7.5e-19 6.5e-19 4.0e-19
8 Liver mRNA stability Ap3d1 0.03 0.03 1.2e-04 0.03 0.03 0.03 0.03 1.2e-04 1.7e-04 3.5e-04 3.5e-04
9 LHb mRNA stability Ap3d1 0.14 0.1 1.0e-03 0.15 0.1 0.12 0.12 2.6e-04 2.8e-03 9.6e-04 8.5e-04
10 Brain mRNA stability Ap3d1 0.15 0.08 0.0e+00 0.17 0.16 0.16 0.16 2.7e-15 8.2e-15 1.3e-14 1.9e-14
11 PL mRNA stability Ap3d1 0.11 0.07 8.3e-15 0.14 0.14 0.13 0.14 8.2e-15 1.2e-14 1.9e-14 6.1e-15
12 BLA mRNA stability Ap3d1 0.19 0.21 8.0e-05 0.05 0.06 0.08 0.05 1.3e-03 5.1e-04 3.3e-05 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.30.51.1-1.11.1-0.10.00.60.6-0.70.70.80.6-0.80.5
Area under the delay curve2.42.53.31.4-1.31.6-1.61.81.6-1.61.61.61.6-1.61.3
BMI with tail6.621.323.74.9-4.94.8-4.84.54.6-4.54.54.54.6-4.54.3
BMI without tail2.24.67.62.8-2.72.4-2.42.02.0-1.81.81.92.0-1.91.5
Body weight1.14.85.52.3-2.32.3-2.32.22.2-2.12.12.12.3-2.11.9
Weight adjusted by age0.30.30.80.9-0.90.7-0.70.20.4-0.30.30.30.4-0.3-0.0
Bone surface0.50.94.4-2.12.1-0.70.70.30.3-0.40.40.50.3-0.40.1
Bone volume0.50.94.5-2.12.1-0.70.70.30.3-0.40.40.50.3-0.40.1
Breakpoint value in progressive ratio session5.86.47.5-2.12.1-2.52.5-2.7-2.62.6-2.6-2.6-2.72.6-2.7
Number of licking bursts0.10.10.40.6-0.60.2-0.2-0.2-0.20.1-0.1-0.1-0.00.1-0.2
Context. condit. distance diff. score0.30.30.40.6-0.60.6-0.60.60.5-0.50.50.60.6-0.60.3
Locomotion velocity, session 10.50.51.3-1.21.2-0.80.8-0.4-0.50.6-0.6-0.5-0.50.5-0.2
Locomotion distance, session 10.20.30.9-0.90.9-0.50.40.20.1-0.20.20.10.1-0.20.9
Locomotion velocity, session 23.03.56.3-2.52.5-2.22.2-1.5-1.61.8-1.8-1.6-1.71.6-0.9
Locomotion distance, session 21.21.74.2-2.02.0-1.61.6-0.9-1.01.0-1.0-1.0-1.01.0-0.0
Locomotion velocity, session 36.37.48.2-2.52.5-2.72.7-2.7-2.72.8-2.8-2.8-2.92.8-2.8
Locomotion distance, session 30.00.00.10.1-0.10.1-0.1-0.0-0.1-0.00.00.0-0.0-0.0-0.2
Stereotopy head waving bouts, day 34.65.46.4-2.52.5-2.52.5-2.2-2.22.3-2.3-2.3-2.32.3-1.8
Stereotopy head waving duration, day 35.76.87.6-2.62.6-2.82.7-2.5-2.52.6-2.6-2.6-2.62.6-2.2
Locomotion velocity, session 70.80.92.1-1.11.1-0.80.8-0.8-0.80.9-0.9-0.8-0.70.9-1.5
Locomotion distance, session 70.10.10.40.6-0.60.4-0.40.10.1-0.00.00.10.2-0.1-0.4
Stereotopy head waving bouts, day 70.10.10.3-0.50.5-0.10.10.30.3-0.30.30.20.2-0.20.3
Stereotopy head waving duration, day 70.20.21.0-1.01.0-0.50.5-0.1-0.10.1-0.1-0.1-0.20.1-0.0
Locomotion velocity, session 80.40.52.0-1.41.4-0.90.8-0.3-0.30.4-0.4-0.4-0.40.40.0
Locomotion distance, session 80.10.10.3-0.50.5-0.40.4-0.2-0.20.3-0.3-0.2-0.20.20.2
Degree of sensitization distance0.30.40.50.5-0.50.6-0.60.60.6-0.60.60.60.7-0.60.5
Degree of sensitization stereotypy2.12.33.00.9-0.91.4-1.41.61.6-1.71.71.71.6-1.71.5
Conditioned locomotion1.31.53.31.8-1.81.4-1.41.01.1-0.90.90.91.0-0.90.9
Cocaine response after cond. corrected4.65.18.62.9-2.92.6-2.62.12.0-1.91.91.92.1-2.01.6
Cocaine response after cond. not corrected4.95.49.23.0-3.02.7-2.72.12.1-2.02.01.92.2-2.01.6
Cocaine response before conditioning0.50.60.9-0.90.9-0.80.8-0.7-0.60.7-0.7-0.7-0.70.7-0.8
Saline control response0.00.10.20.4-0.40.2-0.20.10.2-0.10.10.10.2-0.20.3
Bone: connectivity density0.40.71.2-0.40.40.4-0.41.01.0-1.01.01.10.9-1.10.8
Bone: cortical apparent density0.81.01.11.0-1.01.0-1.01.01.0-1.01.01.10.9-1.10.9
Bone: cortical area0.60.91.40.1-0.10.8-0.81.11.1-1.11.11.21.2-1.10.7
Bone: cortical porosity0.50.51.2-1.11.1-0.80.8-0.6-0.60.5-0.5-0.6-0.50.6-0.5
Bone: cortical porosity0.10.10.6-0.70.7-0.20.20.10.1-0.20.20.20.3-0.20.3
Bone: cortical thickness1.11.92.30.9-0.91.3-1.31.51.5-1.51.51.51.5-1.51.3
Bone: cortical thickness0.10.10.30.4-0.40.1-0.0-0.3-0.30.3-0.3-0.3-0.20.3-0.6
Bone: cortical tissue density0.50.70.80.8-0.80.8-0.80.80.8-0.80.80.90.7-0.90.8
Condit. Reinf. active minus inactive responses4.14.65.1-2.12.1-2.22.3-2.1-2.22.2-2.2-2.1-2.22.1-2.0
Condit. Reinf. active-inactive response ratio2.32.43.1-1.21.2-1.51.5-1.6-1.71.6-1.6-1.6-1.71.6-1.8
Condit. Reinf. active responses3.34.05.3-2.32.3-2.32.3-1.9-1.91.9-1.9-1.8-2.01.9-1.4
Condit. Reinf. inactive responses0.70.81.9-1.41.4-1.11.1-0.6-0.70.7-0.7-0.6-0.70.70.0
Incentive salience index mean1.92.33.3-1.81.8-1.71.7-1.4-1.51.4-1.4-1.4-1.51.4-1.1
Condit. Reinf. lever presses0.20.30.9-0.80.8-0.30.20.40.2-0.40.40.40.3-0.40.9
Condit. Reinf. active minus inactive responses2.53.14.0-1.31.3-1.71.7-1.9-1.91.8-1.8-1.9-1.91.9-2.0
Condit. Reinf. active-inactive response ratio0.30.30.40.4-0.4-0.20.2-0.6-0.70.6-0.6-0.6-0.50.6-0.4
Condit. Reinf. active responses2.43.34.8-1.71.7-1.71.8-1.8-1.91.8-1.8-1.8-1.81.8-2.2
Condit. Reinf. inactive responses1.31.62.8-1.51.5-1.21.2-1.1-1.11.1-1.1-1.2-1.21.1-1.7
Condit. Reinf. lever presses2.63.54.4-1.41.4-1.81.8-2.0-2.02.0-2.0-2.1-1.92.0-2.1
Condit. Reinf. lever reinforcers received1.92.64.3-1.31.3-1.51.5-1.7-1.71.6-1.6-1.7-1.61.6-2.1
Conditioned reinforcement - actives2.42.43.0-1.71.7-1.61.6-1.7-1.71.4-1.4-1.4-1.41.4-1.6
Conditioned reinforcement - inactives0.40.50.80.9-0.90.8-0.80.50.6-0.60.60.60.5-0.60.6
Conditioned locomotion7.59.010.5-3.03.0-3.13.1-3.1-3.22.9-2.9-2.9-2.92.9-3.0
Patch foraging indifference point 0 sec0.10.20.40.2-0.20.4-0.40.50.5-0.50.50.50.6-0.50.5
Patch foraging indifference point AUC0.91.01.4-0.80.8-1.01.0-1.1-1.21.0-1.0-1.0-0.91.0-0.9
Delay disc. indifference point, 0s delay7.88.612.01.9-1.92.7-2.73.13.1-3.23.23.23.2-3.23.5
Delay disc. indifference point, 16s delay0.10.20.30.4-0.40.4-0.40.60.4-0.40.40.40.3-0.40.3
Delay disc. indifference point, 2s delay6.06.67.72.0-2.02.6-2.62.72.7-2.82.82.82.7-2.82.4
Delay disc. indifference point, 24s delay0.70.71.01.0-1.00.9-0.91.00.8-0.70.70.70.8-0.70.5
Delay disc. indifference point, 4s delay1.21.32.00.7-0.71.1-1.11.41.3-1.21.21.21.0-1.21.0
Delay disc. indifference point, 8s delay1.21.21.61.3-1.31.2-1.21.11.0-1.01.01.01.1-1.00.8
Indifference point function ln k0.20.30.40.4-0.40.6-0.60.50.6-0.50.50.50.5-0.60.1
Indifference point function log k0.20.30.40.4-0.40.6-0.60.50.6-0.50.50.50.5-0.60.1
Patch foraging total patch changes 0 sec0.10.10.30.2-0.20.4-0.40.40.4-0.40.40.40.5-0.40.4
Patch foraging total patch changes 12 sec0.30.41.21.1-1.10.7-0.70.40.4-0.40.40.40.6-0.30.5
Patch foraging total patch changes 18 sec1.11.41.6-1.11.1-1.21.2-1.3-1.21.2-1.2-1.2-1.11.2-1.1
Patch foraging total patch changes 24 sec0.10.10.1-0.20.2-0.30.3-0.3-0.30.3-0.3-0.3-0.20.3-0.1
Patch foraging total patch changes 6 sec0.20.30.4-0.60.6-0.60.6-0.6-0.60.6-0.6-0.5-0.40.6-0.4
Patch foraging time to switch 0 sec1.62.55.60.9-0.81.3-1.31.81.8-1.61.61.61.6-1.62.4
Patch foraging water rate 0 sec0.20.31.50.4-0.50.1-0.0-0.6-0.60.3-0.3-0.3-0.30.3-1.2
Patch foraging water rate 12 sec0.81.23.41.8-1.91.4-1.30.80.8-0.70.70.70.9-0.80.3
Patch foraging water rate 18 sec0.60.82.00.8-0.9-0.00.1-1.0-1.00.9-0.9-0.9-0.80.8-1.4
Patch foraging water rate 24 sec0.40.62.91.6-1.70.8-0.7-0.1-0.1-0.00.00.00.0-0.0-0.5
Patch foraging water rate 6 sec0.60.92.30.1-0.1-0.50.5-1.1-1.11.1-1.1-1.0-0.91.0-1.5
Seeking ratio, delayed vs. immediate footshock4.55.16.5-2.52.5-2.42.4-2.2-2.22.1-2.1-2.1-2.12.1-2.2
Distance traveled before self-admin0.50.50.80.4-0.40.6-0.60.70.5-0.90.90.90.9-0.90.8
Distance traveled after self-admin0.60.71.0-1.01.0-0.90.9-0.8-1.00.8-0.8-0.8-0.60.7-0.8
Extensor digitorum longus weight4.618.022.54.7-4.74.6-4.54.13.9-4.24.24.14.1-4.03.6
Bone: elastic displacement0.30.30.4-0.70.7-0.60.6-0.5-0.50.5-0.5-0.5-0.50.5-0.5
Bone: elastic work0.20.20.40.0-0.00.5-0.50.60.6-0.50.50.60.7-0.60.2
Bone: endosteal estimation0.20.40.60.3-0.30.6-0.60.80.8-0.70.70.80.7-0.80.5
Bone: endosteal perimeter0.20.51.4-1.21.2-0.70.7-0.4-0.40.5-0.5-0.5-0.50.4-0.8
Epididymis fat weight0.20.50.9-0.20.2-0.70.6-0.8-0.80.8-0.8-0.8-0.90.8-0.5
Delta time in closed arm before/after self-admin0.70.62.51.6-1.61.0-0.90.30.3-0.40.40.40.4-0.40.1
Delta time in open arm before/after self-admin1.31.21.60.9-0.91.1-1.11.31.2-1.11.11.11.2-1.11.3
Diff in mean of infusions in LGA sessions1.82.02.4-1.31.2-1.51.5-1.4-1.41.5-1.5-1.5-1.61.4-1.3
Delay discount exponential model param2.22.33.0-1.41.3-1.61.5-1.7-1.51.5-1.5-1.5-1.61.5-1.2
Extinction: sum of active levers before priming1.41.42.3-0.70.6-1.11.1-1.5-1.41.2-1.2-1.2-1.21.2-1.4
Active lever presses in extinction session 63.02.93.4-1.91.8-1.81.8-1.8-1.81.6-1.6-1.6-1.51.6-1.7
Bone: final force1.32.13.00.8-0.81.4-1.41.61.6-1.61.61.61.7-1.61.2
Bone: final moment1.01.62.40.6-0.61.2-1.21.41.4-1.41.41.41.5-1.41.0
Food consumed during 24 hour testing period0.60.71.00.8-0.80.9-0.80.70.7-0.90.91.00.8-0.90.4
Glucose1.32.02.31.5-1.51.5-1.51.41.3-1.41.41.41.5-1.41.2
Heart weight0.40.50.8-0.20.2-0.60.6-0.8-0.80.9-0.9-0.8-0.90.9-0.8
Delay discount hyperbolic model param3.03.23.9-1.51.5-1.81.8-2.0-1.91.9-1.9-1.9-1.91.8-1.5
Intermittent access intake day 1-15 change7.27.18.0-2.42.4-2.72.7-2.8-2.82.7-2.7-2.7-2.62.7-2.8
Intermittent access intake escalation7.17.08.6-2.02.0-2.52.6-2.9-2.92.7-2.7-2.7-2.72.7-2.9
Intermittent access intake escalation 28.78.610.3-2.22.2-2.82.8-3.2-3.23.1-3.1-3.1-2.93.1-3.2
Intermitt. access day 1 inactive lever presses0.30.30.8-0.20.2-0.40.4-0.7-0.90.5-0.5-0.5-0.50.5-0.9
Intermitt. access day 15 inactive lever presses0.60.60.8-0.50.5-0.70.7-0.8-0.80.9-0.9-0.9-0.80.9-0.8
Intermitt. access escalation Index0.40.40.6-0.10.10.3-0.30.70.7-0.80.80.80.6-0.80.7
Intermittent access day 1 total infusions0.00.00.10.0-0.00.2-0.20.20.3-0.20.20.20.2-0.20.2
Intermittent access day 15 total infusions2.32.53.1-1.31.3-1.51.5-1.8-1.71.7-1.7-1.7-1.61.7-1.8
Intermittent access terminal intake (last 3 days)1.31.41.8-1.11.1-1.11.1-1.3-1.21.2-1.2-1.2-1.11.2-1.3
Intermittent access total infusions0.30.30.5-0.50.5-0.50.5-0.7-0.60.5-0.5-0.5-0.50.5-0.6
Intermittent access day 1 locomotion0.40.40.6-0.60.6-0.60.6-0.7-0.60.7-0.7-0.7-0.80.7-0.6
Intermittent access day 15 total locomotion3.84.04.6-1.81.8-2.12.1-2.1-2.22.0-2.0-2.0-2.12.0-1.9
Intermittent access total locomotion1.01.21.4-1.21.2-1.11.1-1.2-1.21.0-1.0-1.0-1.01.0-1.0
Intermittent access standard deviation3.33.54.3-1.51.5-1.81.8-2.1-2.11.9-1.9-1.9-1.81.9-2.0
Left kidney weight0.00.10.4-0.60.6-0.30.3-0.0-0.00.1-0.1-0.10.00.10.0
Right kidney weight1.44.04.7-2.22.1-2.12.1-2.0-2.02.0-2.0-2.0-1.82.0-2.0
Cocaine induced anxiety0.50.61.4-1.21.2-0.90.9-0.6-0.60.7-0.7-0.7-0.40.6-0.2
Post-drug Anxiety0.40.41.0-1.01.0-0.70.7-0.3-0.30.7-0.7-0.7-0.50.6-0.0
Baseline Anxiety0.20.20.40.1-0.1-0.20.2-0.3-0.30.6-0.6-0.6-0.60.6-0.6
Tail length3.310.011.3-2.82.8-3.13.1-3.2-3.33.3-3.3-3.3-3.13.2-3.4
Length with tail2.07.28.8-3.02.9-2.72.8-2.6-2.62.6-2.6-2.6-2.42.6-2.7
Length without tail0.10.21.0-1.01.0-0.40.4-0.00.0-0.00.0-0.0-0.00.00.0
Times rat made contact with spout0.20.20.60.8-0.80.5-0.50.30.3-0.30.30.30.3-0.30.2
Lifetime Intake0.10.10.2-0.40.4-0.30.3-0.5-0.30.3-0.3-0.3-0.30.3-0.4
Liver weight, left2.54.05.62.4-2.42.1-2.11.91.9-1.81.81.81.8-1.82.1
Liver weight, right1.93.14.11.7-1.71.7-1.71.71.8-1.81.81.71.7-1.72.0
Locomotor activity3.25.28.6-2.92.9-2.52.5-2.1-2.12.0-2.0-2.0-1.82.0-2.0
Locomotor testing distance2.03.45.0-2.22.2-2.02.0-1.8-1.71.7-1.7-1.7-1.51.7-1.7
Locomotor testing rearing0.10.10.40.1-0.1-0.10.1-0.3-0.30.4-0.4-0.4-0.30.4-0.6
Locomotion in novel chamber0.30.30.7-0.20.2-0.60.6-0.8-0.80.7-0.7-0.6-0.50.6-0.4
Locomotion in novel chamber post-restriction0.91.02.0-0.91.0-0.91.0-1.0-0.91.0-1.0-1.0-1.11.0-1.4
Fecal boli incidents, locomotor time 11.81.93.11.7-1.71.4-1.41.11.2-1.21.21.21.4-1.21.7
Change in fecal boli incidents, locomotor task0.40.41.3-1.11.1-0.50.5-0.4-0.30.3-0.3-0.3-0.20.2-1.0
Time >=10cm from walls, locomotor time 10.50.51.40.1-0.10.5-0.50.70.6-0.70.70.71.2-0.71.0
Bouts of movement, locomotor time 10.20.20.3-0.30.3-0.40.4-0.5-0.50.5-0.5-0.5-0.40.5-0.5
Total resting periods, locomotor time 10.30.30.4-0.50.5-0.50.5-0.5-0.60.5-0.5-0.5-0.50.5-0.6
Rest time, locomotor task time 10.20.20.4-0.60.6-0.50.5-0.5-0.50.3-0.3-0.3-0.50.3-0.3
Distance moved, locomotor task time 10.50.61.10.1-0.20.6-0.60.90.9-0.80.80.81.1-0.80.8
Vertical activity count, locomotor time 10.10.10.20.3-0.20.4-0.40.10.2-0.20.20.20.3-0.2-0.4
Time >=10cm from walls, locomotor time 21.11.21.91.3-1.31.2-1.21.00.8-1.01.01.01.4-1.00.9
Bouts of movement, locomotor time 20.30.30.9-1.01.0-0.80.7-0.3-0.40.3-0.3-0.3-0.50.3-0.1
Total resting periods, locomotor time 20.30.30.9-0.90.9-0.70.7-0.2-0.40.3-0.3-0.3-0.50.3-0.0
Rest time, locomotor task time 20.50.60.9-1.00.9-0.80.8-0.5-0.70.7-0.7-0.7-0.60.7-0.4
Distance moved, locomotor task time 20.70.81.31.1-1.11.0-1.00.80.8-0.80.80.80.8-0.80.8
Vertical activity count, locomotor time 20.60.61.51.2-1.21.0-1.00.50.5-0.70.70.70.7-0.70.5
Light reinforcement 15.610.112.0-3.33.3-3.53.5-3.1-3.13.2-3.2-3.2-3.23.2-2.6
Light reinforcement 21.92.63.3-1.81.8-1.81.7-1.5-1.51.5-1.5-1.5-1.71.6-1.3
Bone: marrow area0.20.50.70.3-0.30.6-0.60.80.8-0.80.80.80.7-0.80.5
Bone: maximum diameter0.61.23.0-1.71.7-1.21.2-0.8-0.80.8-0.8-0.8-0.80.8-1.0
Bone: maximum force1.22.12.90.9-0.91.5-1.51.61.6-1.51.51.51.7-1.61.0
Bone: maximum moment1.01.72.40.8-0.81.3-1.31.51.5-1.41.41.41.5-1.40.9
Mean time between licks in bursts4.46.27.0-2.12.1-2.52.5-2.6-2.62.6-2.6-2.6-2.52.6-2.5
Mean num. licks in bursts0.00.10.1-0.00.00.2-0.20.30.3-0.30.30.30.2-0.30.2
Cd content in liver0.20.20.30.3-0.30.4-0.40.50.5-0.50.50.50.5-0.50.5
Co content in liver0.60.70.9-0.60.6-0.80.8-0.9-0.90.9-0.9-0.9-0.90.8-0.8
Cu content in liver0.20.20.3-0.20.20.2-0.20.60.5-0.50.50.50.6-0.50.6
Fe content in liver0.00.00.10.1-0.1-0.10.1-0.3-0.20.3-0.3-0.3-0.30.2-0.2
K content in liver0.10.10.3-0.40.4-0.10.10.30.2-0.30.30.30.3-0.40.6
Mg content in liver0.10.10.3-0.50.5-0.00.00.40.2-0.30.30.30.4-0.40.5
Mn content in liver0.91.03.9-2.02.0-1.11.1-0.5-0.50.5-0.5-0.5-0.50.4-0.5
Na content in liver1.21.32.30.5-0.50.9-0.91.21.2-1.21.21.31.2-1.31.5
Rb content in liver0.50.71.10.0-0.00.6-0.60.90.9-1.01.01.00.9-1.01.0
Se content in liver0.10.10.2-0.50.5-0.50.5-0.4-0.40.2-0.2-0.3-0.40.3-0.3
Sr content in liver0.10.10.20.4-0.40.0-0.0-0.3-0.30.2-0.2-0.2-0.30.2-0.4
Zn content in liver2.12.33.5-0.50.5-1.31.3-1.8-1.91.6-1.6-1.7-1.81.7-1.8
Bone: minimum diameter0.00.10.2-0.40.40.0-0.00.30.3-0.30.30.30.3-0.3-0.1
Time in familiar zone, hab. session 12.72.53.5-1.21.2-1.41.4-1.6-1.51.8-1.8-1.8-1.71.7-1.9
Time in novel zone, hab. session 11.31.31.90.4-0.40.9-0.91.21.1-1.41.41.31.3-1.31.2
Total zone transitions, hab. session 10.71.02.5-1.61.6-1.21.2-0.7-0.80.8-0.8-0.8-0.80.7-0.2
Total locomotion distance, hab. session 10.91.34.0-2.02.0-1.31.3-0.6-0.60.8-0.8-0.8-0.70.7-0.2
Locomotion velocity, hab. session 11.21.74.1-2.02.0-1.61.6-1.0-1.01.1-1.1-1.1-1.01.0-0.3
Time in familiar zone, hab. session 26.87.18.4-2.02.0-2.52.5-2.8-2.72.9-2.9-2.8-2.82.8-2.9
Time in novel zone, hab. session 25.15.16.11.6-1.62.1-2.22.42.4-2.52.52.42.4-2.42.3
Total zone transitions, hab. session 20.50.63.1-0.30.30.2-0.20.80.8-0.70.70.70.7-0.81.8
Total locomotion distance, hab. session 20.71.02.0-1.41.4-1.21.2-0.7-0.70.8-0.8-0.9-0.80.80.1
Locomotion velocity, hab. session 20.70.92.3-1.51.5-1.21.2-0.6-0.60.7-0.7-0.7-0.70.70.4
Novel to familiar place preference ratio4.74.85.91.4-1.42.0-2.02.32.3-2.42.42.42.4-2.42.4
Novelty place preference2.93.03.91.0-1.01.5-1.51.91.8-2.02.01.91.9-1.91.9
Time in novel zone, NPP test3.33.34.21.1-1.11.7-1.72.01.9-2.02.02.02.0-2.02.0
Total zone transitions, NPP test0.10.21.6-0.30.3-0.10.10.30.3-0.20.20.20.2-0.21.3
Total locomotion distance, NPP test0.20.21.3-0.30.3-0.0-0.00.50.5-0.30.30.30.4-0.41.1
Locomotion velocity, NPP test0.10.20.8-0.60.6-0.30.30.20.2-0.00.00.00.1-0.10.9
Intraocular pressure0.20.30.60.8-0.70.0-0.0-0.5-0.40.5-0.5-0.5-0.40.5-0.6
Delta distance traveled before/after self-admin1.82.02.3-1.31.4-1.41.4-1.3-1.31.5-1.5-1.5-1.41.5-1.3
Delta ambulatory time before/after self-admin1.82.02.2-1.51.5-1.51.5-1.3-1.31.5-1.5-1.4-1.41.4-1.3
Parametrial fat weight0.50.91.6-0.80.8-0.90.9-1.1-1.01.0-1.0-1.0-0.81.0-1.3
Pavlov. Cond. lever latency0.10.10.30.4-0.40.00.0-0.4-0.40.4-0.4-0.3-0.30.3-0.6
Pavlov. Cond. magazine entry latency2.93.84.3-1.71.7-2.02.0-2.0-2.02.0-2.0-2.0-2.12.1-1.8
Pavlov. Cond. change in total contacts0.00.00.1-0.30.3-0.30.3-0.2-0.20.1-0.1-0.2-0.20.20.0
Pavlov. Cond. index score0.30.40.8-0.90.9-0.80.8-0.5-0.50.5-0.5-0.5-0.60.6-0.3
Pavlov. Cond. latency score0.30.41.1-1.11.1-0.80.7-0.4-0.40.4-0.4-0.4-0.50.5-0.1
Pavlov. Cond. lever contacts0.10.10.5-0.70.7-0.20.20.20.2-0.30.30.20.1-0.20.5
Pavlov. Cond. magazine entry number0.60.81.00.8-0.81.0-1.00.90.9-0.90.90.91.0-0.90.7
Pavlov. Cond. intertrial magazine entries0.20.20.40.1-0.1-0.30.3-0.6-0.60.6-0.6-0.5-0.60.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.60.81.3-1.11.1-1.01.0-0.8-0.80.8-0.8-0.8-0.90.9-0.6
Pavlov. Cond. response bias1.01.21.5-1.11.1-1.21.2-1.1-1.11.1-1.1-1.1-1.21.2-0.9
Pavlov. Cond. lever latency0.91.32.41.2-1.21.0-1.01.11.0-1.11.11.20.9-1.11.5
Pavlov. Cond. magazine entry latency0.50.61.1-0.80.8-0.70.7-0.7-0.70.7-0.7-0.7-0.60.7-1.1
Pavlov. Cond. change in total contacts0.91.22.1-1.01.0-1.01.0-1.1-1.11.1-1.1-1.1-1.01.1-1.4
Pavlov. Cond. index score1.11.42.5-1.11.1-1.01.1-1.1-1.11.2-1.2-1.2-1.01.2-1.6
Pavlov. Cond. latency score1.01.22.1-1.21.2-1.01.0-1.0-1.01.1-1.1-1.1-0.91.1-1.5
Pavlov. Cond. lever contacts0.91.22.5-0.90.9-0.91.0-1.1-1.11.1-1.1-1.2-1.01.2-1.6
Pavlov. Cond. magazine entry number0.81.01.91.1-1.10.9-1.00.91.0-0.90.91.00.9-0.91.4
Pavlov. Cond. intertrial magazine entries0.20.30.80.9-0.90.7-0.70.40.4-0.40.40.40.4-0.40.4
Pavlov. Cond. lever-magazine prob. diff.1.01.32.3-1.21.2-1.11.1-1.1-1.11.1-1.1-1.2-0.91.2-1.5
Pavlov. Cond. response bias2.12.84.7-1.41.4-1.51.6-1.7-1.71.7-1.7-1.8-1.61.8-2.2
Time in closed arm before self-admin1.01.12.30.3-0.30.8-0.81.21.3-1.21.21.21.1-1.21.5
Time in closed arm after self-admin0.00.00.00.0-0.0-0.10.1-0.1-0.10.1-0.1-0.1-0.20.1-0.1
Time in open arm before self-admin0.91.01.7-0.80.8-1.01.0-1.1-1.20.9-0.9-0.9-0.90.9-1.3
Time in open arm after self-admin0.70.80.90.9-0.90.9-0.90.90.8-0.90.90.90.9-0.90.7
Bone: periosteal estimation0.40.81.20.0-0.00.7-0.71.11.1-1.11.11.11.1-1.10.6
Bone: periosteal perimeter0.10.20.9-1.01.0-0.30.30.00.0-0.00.00.00.1-0.0-0.3
Bone: post-yield work0.50.70.90.9-0.90.9-0.90.80.8-0.80.80.80.8-0.80.5
Progressive ratio test 1 active lever presses0.10.10.20.4-0.40.3-0.30.10.2-0.20.20.20.0-0.20.1
Progressive ratio test 1 breakpoint0.10.10.20.5-0.50.4-0.40.20.3-0.30.30.30.1-0.30.2
Progressive ratio test 1 inactive lever presses0.00.00.0-0.20.2-0.10.1-0.1-0.10.0-0.0-0.0-0.20.0-0.0
Progressive ratio test 2 active lever presses0.30.30.6-0.20.2-0.40.4-0.7-0.70.5-0.5-0.5-0.50.5-0.8
Progressive ratio test 2 breakpoint0.30.30.5-0.50.5-0.50.5-0.7-0.70.5-0.5-0.5-0.50.5-0.7
Progressive ratio test 2 inactive lever presses0.10.10.2-0.40.4-0.20.2-0.3-0.20.2-0.2-0.2-0.10.1-0.2
Incentive Sensitization - Responses0.30.30.7-0.20.2-0.40.4-0.7-0.80.4-0.4-0.4-0.40.4-0.8
Incentive Sensitization - Breakpoint0.30.30.7-0.30.3-0.40.5-0.7-0.80.5-0.5-0.5-0.50.5-0.8
Sum of active levers in priming session hrs 5-60.00.00.0-0.0-0.0-0.00.0-0.1-0.1-0.00.00.00.1-0.00.1
Progressive ratio0.30.30.90.9-0.90.5-0.50.40.3-0.30.30.30.3-0.30.9
Food seeking constrained by brief footshock0.10.10.2-0.20.3-0.40.4-0.3-0.30.3-0.3-0.3-0.40.30.2
Seeking ratio, punishment vs. effort0.20.20.6-0.70.8-0.50.5-0.3-0.30.3-0.3-0.3-0.40.2-0.4
Retroperitoneal fat weight0.31.01.51.2-1.21.0-1.11.01.0-0.90.90.90.8-0.90.9
Reaction time number correct0.40.61.71.3-1.31.0-1.00.50.5-0.60.60.70.4-0.6-0.0
Reaction time mean minus median0.81.01.8-0.90.8-0.91.0-1.0-1.11.0-1.0-1.1-1.01.0-1.3
Reaction time mean minus median AUC0.10.10.3-0.60.5-0.10.10.20.2-0.10.10.10.2-0.2-0.1
Reaction time num false alarms0.10.10.50.4-0.40.4-0.40.10.0-0.20.20.20.1-0.1-0.7
Reaction time num false alarms AUC0.10.20.50.7-0.70.5-0.50.10.1-0.20.20.20.1-0.2-0.6
Reaction time trials correct on left0.40.61.71.3-1.31.0-1.00.50.5-0.60.60.70.4-0.6-0.0
Reaction time trials on left0.40.61.61.2-1.31.0-1.00.50.5-0.70.70.70.4-0.70.0
Reaction time mean0.00.00.1-0.30.20.0-0.00.20.2-0.00.00.00.2-0.1-0.0
Reaction time mean AUC0.00.00.1-0.20.20.1-0.10.30.3-0.10.10.10.3-0.20.0
Median of all reaction times0.20.30.60.2-0.20.5-0.50.80.7-0.60.60.60.7-0.60.6
Reaction time omissions0.20.30.6-0.70.7-0.70.7-0.5-0.60.4-0.4-0.4-0.50.4-0.4
Reaction time false alarm rate0.00.00.10.0-0.00.2-0.10.10.1-0.10.10.10.1-0.1-0.3
Reaction time premature initiation rate1.31.72.2-0.90.8-1.21.2-1.4-1.41.4-1.4-1.5-1.31.5-1.4
Reaction time premature initiations0.81.22.4-0.20.2-0.80.8-1.3-1.21.2-1.2-1.2-1.21.2-1.5
Std. dev. reaction times0.20.30.6-0.70.6-0.50.5-0.5-0.50.5-0.5-0.6-0.40.5-0.7
Reaction time trials completed0.40.61.61.2-1.31.0-1.00.50.5-0.70.70.70.4-0.70.0
Reaction time trials AUC0.40.61.81.3-1.31.0-0.90.40.4-0.60.60.60.3-0.6-0.1
Run reversals in cocaine runway, females0.40.40.7-0.80.8-0.70.7-0.5-0.60.5-0.5-0.5-0.60.5-0.7
Run reversals in cocaine runway, males1.31.21.9-1.31.4-1.21.2-1.0-1.01.0-1.0-1.0-1.21.0-0.9
Latency to leave start box in cocaine runway0.91.02.9-1.71.6-1.11.1-0.8-0.80.7-0.7-0.7-0.50.7-0.7
Latency to leave start box in cocaine runway, F0.30.30.9-1.01.0-0.10.10.20.3-0.40.40.40.7-0.50.5
Latency to leave start box in cocaine runway, M3.23.13.8-1.21.0-1.61.6-1.9-1.91.9-1.9-1.9-1.91.9-1.9
Std. dev. time between licks in bursts0.91.02.0-1.41.4-1.01.0-0.8-0.80.9-0.9-0.9-0.80.8-1.3
Total sessions with >9 infusions0.10.10.2-0.40.40.0-0.0-0.00.1-0.30.30.30.3-0.3-0.0
Short access day 1 total inactive lever presses0.00.00.1-0.20.2-0.30.2-0.3-0.20.1-0.1-0.1-0.30.10.2
Short access day 10 total inactive lever presses0.00.00.20.1-0.1-0.10.1-0.3-0.40.2-0.2-0.20.00.2-0.2
Short access day 1 total infusions0.10.20.6-0.80.8-0.40.4-0.3-0.10.2-0.2-0.2-0.20.1-0.0
Short access day 10 total infusions0.00.00.1-0.10.1-0.10.1-0.3-0.20.1-0.1-0.1-0.40.1-0.3
Short access total infusions0.00.00.1-0.20.2-0.00.0-0.10.0-0.10.10.10.1-0.10.0
Short access day 1 locomotion1.01.12.2-1.51.5-1.11.1-1.0-0.90.9-0.9-0.9-0.90.8-1.0
Short access day 10 total locomotion4.24.76.1-2.02.0-2.22.2-2.5-2.42.0-2.0-2.0-2.12.0-2.3
Short access total locomotion1.01.01.5-1.21.2-1.01.0-1.1-1.00.8-0.8-0.8-0.80.8-1.0
One hour access (0.3 mA shock)0.10.10.20.3-0.30.4-0.40.30.4-0.40.40.40.3-0.40.3
Compulsive drug intake1.41.41.90.7-0.71.1-1.11.21.2-1.31.31.31.4-1.31.2
One hour access (shock baseline)0.10.20.4-0.10.1-0.20.2-0.5-0.40.4-0.4-0.4-0.60.4-0.5
Social response proportion0.50.60.9-0.91.0-0.90.9-0.6-0.60.8-0.8-0.7-0.70.8-0.1
Social responses6.98.911.6-3.33.4-3.13.1-2.8-2.82.9-2.9-2.9-2.72.8-2.8
Social time0.70.92.01.1-1.00.8-0.90.90.9-0.70.70.71.0-0.81.4
Soleus weight9.126.529.44.9-4.95.4-5.45.25.2-5.35.35.25.2-5.24.5
Bone: stiffness3.04.75.91.7-1.72.3-2.22.32.3-2.32.32.32.4-2.31.8
Tibialis anterior weight1.24.34.92.0-2.02.1-2.12.11.9-2.22.22.22.1-2.11.7
Time to tail flick, vehicle, before self-admin0.40.41.2-1.11.1-0.70.7-0.4-0.40.3-0.3-0.3-0.40.3-0.3
Time to tail flick, vehicle, after self-admin0.20.30.40.4-0.4-0.20.2-0.5-0.40.6-0.6-0.6-0.60.6-0.6
Time to tail flick, test, before self-admin0.20.20.7-0.80.8-0.50.5-0.2-0.00.2-0.2-0.2-0.20.20.1
Time to tail flick, test, after self-admin0.20.20.4-0.60.6-0.50.5-0.3-0.30.3-0.3-0.3-0.50.3-0.2
Delta time to tail flick, vehicle, before/after SA0.40.41.71.3-1.30.8-0.70.30.4-0.10.10.10.2-0.20.1
Delta time to tail flick, test, before/after SA0.20.20.40.1-0.0-0.30.3-0.4-0.50.5-0.5-0.4-0.60.5-0.5
Tibia length1.02.93.5-1.51.5-1.61.6-1.7-1.71.8-1.8-1.9-1.71.8-1.6
Ambulatory time before self-admin0.40.40.70.4-0.40.5-0.50.60.4-0.80.80.80.8-0.80.7
Ambulatory time after self-admin0.30.40.6-0.70.7-0.70.7-0.6-0.80.5-0.5-0.5-0.40.5-0.5
Bone: tissue strength1.81.72.01.1-1.11.3-1.31.41.4-1.31.31.31.4-1.31.4
Total heroin consumption2.02.32.6-1.61.5-1.61.6-1.6-1.51.4-1.4-1.5-1.51.5-1.6
Bone: trabecular number0.50.82.7-1.61.6-1.01.0-0.6-0.60.5-0.5-0.5-0.60.5-0.6
Bone: trabecular spacing0.50.63.01.7-1.70.8-0.80.10.1-0.00.00.00.2-0.1-0.0
Bone: trabecular thickness0.70.82.5-1.61.6-0.20.20.70.7-0.80.80.70.8-0.70.6
Bone: trabecular tissue density1.62.33.51.9-1.91.6-1.61.41.4-1.31.31.31.4-1.31.6
Water consumed over 24 hours0.60.81.10.3-0.30.8-0.81.01.0-1.01.01.11.0-1.00.8
Number of responses in last shaping day0.20.20.4-0.70.7-0.40.4-0.6-0.40.3-0.3-0.3-0.40.3-0.6