Hub : Genes

Ap3d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Ap3d1 0.38 0.22 1.2e-03 0.04 0.02 0.05 0.04 4.2e-03 3.3e-02 1.5e-03 2.1e-03
2 Liver gene expression Ap3d1 0.09 0.06 2.8e-11 0.08 0.09 0.09 0.09 2.2e-09 1.4e-10 4.2e-10 3.1e-10
3 NAcc gene expression Ap3d1 0.03 0.04 2.3e-03 0.02 0.02 0.01 0.02 7.2e-04 1.4e-03 3.1e-03 8.4e-04
4 pVTA mRNA stability Ap3d1 0.09 0.06 2.2e-07 0.06 0.07 0.07 0.07 8.9e-06 1.6e-06 2.4e-06 1.4e-06
5 NAcc mRNA stability Ap3d1 0.07 0.04 8.5e-15 0.1 0.1 0.1 0.1 2.7e-14 1.6e-14 2.4e-14 3.0e-14
6 LHb mRNA stability Ap3d1 0.15 0.1 9.0e-04 0.13 0.1 0.12 0.11 4.9e-04 2.0e-03 9.7e-04 1.6e-03
7 Liver intron excision ratio chr7_9650697_9651063 0.03 0.03 1.3e-04 0.03 0.03 0.03 0.03 1.2e-04 1.9e-04 1.4e-04 1.2e-04
8 Liver mRNA stability Ap3d1 0.03 0.03 1.1e-04 0.03 0.03 0.02 0.03 1.2e-04 1.9e-04 1.5e-03 2.6e-04
9 Brain mRNA stability Ap3d1 0.13 0.07 2.3e-15 0.15 0.14 0.15 0.14 7.6e-14 2.3e-13 1.2e-13 4.6e-13
10 Adipose gene expression Ap3d1 0.18 0.11 0.0e+00 0.18 0.17 0.19 0.18 4.3e-20 6.4e-19 3.1e-20 1.3e-19
11 PL mRNA stability Ap3d1 0.13 0.09 1.1e-13 0.12 0.12 0.12 0.12 4.8e-13 2.2e-13 6.7e-13 3.0e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.61.5-0.70.1-0.90.9-0.5-0.7-0.7-0.7-0.70.7-1.2
Area under the delay curve2.12.43.01.51.61.4-1.3-1.6-1.6-1.6-1.6-1.61.7-1.6
BMI with tail6.522.426.54.84.95.1-5.1-4.8-4.6-4.6-4.7-4.64.6-4.1
BMI without tail2.06.18.72.92.62.8-2.8-2.4-2.3-2.3-2.3-2.42.2-1.9
Body weight0.94.04.91.92.12.2-2.2-2.0-1.9-1.9-2.0-2.11.9-1.7
Weight adjusted by age0.30.41.01.00.70.8-0.8-0.5-0.5-0.5-0.5-0.50.3-0.3
Bone surface0.61.13.8-1.6-0.6-2.02.00.0-0.4-0.4-0.3-0.20.4-1.1
Bone volume0.61.13.9-1.5-0.5-2.02.0-0.0-0.4-0.4-0.3-0.40.4-1.2
Breakpoint value in progressive ratio session3.54.25.0-1.6-2.2-1.61.82.22.22.22.22.2-1.82.2
Number of licking bursts0.10.20.40.70.20.6-0.60.10.20.20.20.1-0.30.5
Context. condit. distance diff. score0.30.40.50.70.70.7-0.7-0.7-0.6-0.6-0.6-0.70.6-0.6
Locomotion velocity, session 10.60.62.2-1.5-0.8-1.11.10.50.50.50.50.3-0.40.1
Locomotion distance, session 10.30.42.3-1.5-0.4-0.90.90.1-0.1-0.1-0.1-0.10.1-0.5
Locomotion velocity, session 23.54.110.2-3.2-2.2-2.62.61.81.61.61.61.7-1.51.1
Locomotion distance, session 21.72.37.3-2.7-1.6-2.12.11.21.01.01.01.1-1.00.5
Locomotion velocity, session 36.06.97.8-2.4-2.7-2.52.52.72.72.72.72.8-2.62.5
Locomotion distance, session 30.00.00.00.20.00.1-0.10.00.10.10.10.1-0.00.1
Stereotopy head waving bouts, day 34.75.57.3-2.7-2.5-2.52.52.32.22.22.22.5-2.21.9
Stereotopy head waving duration, day 35.86.98.6-2.9-2.8-2.72.72.72.52.52.52.9-2.52.3
Locomotion velocity, session 70.50.61.0-0.5-0.7-1.01.00.80.80.80.80.6-0.80.5
Locomotion distance, session 70.20.21.01.00.50.7-0.7-0.3-0.1-0.1-0.1-0.30.20.0
Stereotopy head waving bouts, day 70.20.20.4-0.60.0-0.40.4-0.2-0.4-0.4-0.4-0.10.4-0.7
Stereotopy head waving duration, day 70.40.41.6-1.2-0.6-1.11.10.40.20.20.20.4-0.2-0.2
Locomotion velocity, session 80.60.72.8-1.7-0.8-1.41.40.50.30.30.30.3-0.3-0.1
Locomotion distance, session 80.10.20.9-1.0-0.4-0.60.60.30.20.20.20.1-0.20.0
Degree of sensitization distance0.50.50.80.70.70.6-0.6-0.7-0.7-0.7-0.7-0.90.7-0.7
Degree of sensitization stereotypy1.71.92.90.81.30.9-0.9-1.5-1.5-1.5-1.5-1.51.6-1.7
Conditioned locomotion1.21.43.01.51.31.7-1.7-1.1-1.0-1.0-1.0-0.90.8-0.5
Cocaine response after cond. corrected4.95.99.13.02.63.0-3.0-2.3-2.1-2.1-2.1-2.22.1-1.7
Cocaine response after cond. not corrected5.36.210.13.22.73.0-3.0-2.4-2.2-2.2-2.2-2.22.1-1.7
Cocaine response before conditioning0.40.51.0-0.7-0.8-1.01.00.70.60.60.70.7-0.50.5
Saline control response0.10.20.50.70.40.7-0.7-0.3-0.2-0.2-0.1-0.30.5-0.0
Bone: connectivity density0.40.61.7-0.10.5-0.20.2-0.8-1.0-1.0-1.0-0.90.9-1.3
Bone: cortical apparent density0.81.21.51.01.10.9-0.9-1.1-1.1-1.1-1.1-1.01.2-1.1
Bone: cortical area0.50.71.70.30.7-0.00.1-0.9-1.0-1.0-1.0-1.11.0-1.3
Bone: cortical porosity0.20.20.6-0.8-0.4-0.80.80.30.20.20.20.0-0.3-0.0
Bone: cortical porosity0.20.20.5-0.7-0.1-0.70.7-0.1-0.2-0.2-0.2-0.40.2-0.5
Bone: cortical thickness1.01.72.50.91.30.7-0.7-1.4-1.4-1.4-1.5-1.51.5-1.6
Bone: cortical thickness0.10.10.30.4-0.10.3-0.20.30.40.40.40.4-0.40.6
Bone: cortical tissue density0.60.81.00.80.90.7-0.7-0.9-0.9-0.9-0.9-0.81.0-0.9
Condit. Reinf. active minus inactive responses4.24.65.6-2.2-2.2-2.02.12.22.22.22.22.4-2.12.0
Condit. Reinf. active-inactive response ratio2.22.32.9-1.1-1.5-1.11.21.61.71.71.71.7-1.61.7
Condit. Reinf. active responses3.64.47.4-2.7-2.3-2.32.32.01.91.91.92.1-1.91.6
Condit. Reinf. inactive responses0.80.93.0-1.7-1.1-1.41.40.80.60.60.60.4-0.60.3
Incentive salience index mean2.12.64.2-2.1-1.7-1.81.91.61.51.51.51.6-1.41.2
Condit. Reinf. lever presses0.20.31.2-1.1-0.3-0.70.8-0.1-0.2-0.2-0.2-0.20.3-0.6
Condit. Reinf. active minus inactive responses2.43.14.2-1.2-1.7-1.31.31.92.02.02.01.9-1.92.0
Condit. Reinf. active-inactive response ratio0.30.30.90.2-0.20.5-0.50.50.70.70.70.5-0.71.0
Condit. Reinf. active responses2.33.34.0-1.4-1.8-1.71.71.91.91.92.01.9-1.71.8
Condit. Reinf. inactive responses1.11.42.3-1.0-1.2-1.51.51.21.21.21.21.2-0.90.9
Condit. Reinf. lever presses1.92.63.2-1.1-1.6-1.31.31.71.81.81.81.7-1.61.8
Condit. Reinf. lever reinforcers received1.72.43.2-1.0-1.5-1.31.31.71.71.71.81.7-1.51.7
Conditioned reinforcement - actives1.11.83.6-0.6-1.2-0.80.81.41.51.51.51.3-1.91.6
Conditioned reinforcement - inactives0.00.10.20.40.20.5-0.5-0.00.00.00.00.1-0.20.2
Conditioned locomotion7.69.911.4-2.7-3.3-3.03.03.33.43.43.43.0-3.13.0
Patch foraging indifference point 0 sec0.20.30.50.40.50.2-0.2-0.6-0.7-0.7-0.6-0.70.6-0.7
Patch foraging indifference point AUC0.91.31.8-0.9-1.1-0.80.81.21.31.31.31.1-1.31.3
Delay disc. indifference point, 0s delay7.98.712.11.92.92.1-2.1-3.2-3.3-3.3-3.2-3.33.1-3.5
Delay disc. indifference point, 16s delay0.20.20.50.40.40.3-0.2-0.5-0.4-0.4-0.5-0.30.7-0.5
Delay disc. indifference point, 2s delay6.57.28.92.22.72.1-2.2-2.8-2.9-2.9-2.8-2.83.0-2.9
Delay disc. indifference point, 24s delay0.50.61.21.10.80.9-0.8-0.7-0.6-0.6-0.7-0.80.8-0.6
Delay disc. indifference point, 4s delay1.51.52.31.11.20.7-0.7-1.3-1.3-1.3-1.4-1.11.5-1.5
Delay disc. indifference point, 8s delay1.11.21.71.31.21.3-1.2-1.1-1.0-1.0-1.0-1.21.0-0.9
Indifference point function ln k0.10.20.60.80.50.3-0.3-0.4-0.4-0.4-0.4-0.30.5-0.4
Indifference point function log k0.10.20.60.80.50.3-0.3-0.4-0.4-0.4-0.4-0.30.5-0.4
Patch foraging total patch changes 0 sec0.10.20.40.30.40.2-0.2-0.5-0.6-0.6-0.5-0.60.5-0.6
Patch foraging total patch changes 12 sec0.40.51.30.90.71.1-1.2-0.6-0.6-0.6-0.5-0.70.4-0.2
Patch foraging total patch changes 18 sec0.71.11.3-1.1-1.1-1.11.11.11.11.11.10.9-1.01.0
Patch foraging total patch changes 24 sec0.00.10.2-0.4-0.3-0.30.30.30.20.20.20.1-0.10.2
Patch foraging total patch changes 6 sec0.20.30.7-0.8-0.6-0.60.70.50.40.40.50.3-0.60.3
Patch foraging time to switch 0 sec1.22.43.80.31.30.7-0.8-1.6-1.9-1.9-1.8-1.71.7-1.9
Patch foraging water rate 0 sec0.20.41.01.00.00.6-0.60.30.60.60.70.4-0.60.8
Patch foraging water rate 12 sec0.71.54.32.11.31.8-1.8-0.9-0.7-0.7-0.7-0.80.7-0.3
Patch foraging water rate 18 sec0.61.02.41.2-0.11.0-1.00.71.01.01.00.9-0.81.5
Patch foraging water rate 24 sec0.71.03.41.80.71.8-1.8-0.20.10.10.2-0.1-0.10.6
Patch foraging water rate 6 sec0.60.82.00.4-0.50.1-0.10.91.21.21.11.0-1.01.4
Seeking ratio, delayed vs. immediate footshock3.84.76.3-2.1-2.3-2.52.42.22.22.22.22.1-1.71.8
Distance traveled before self-admin0.10.20.50.40.30.2-0.1-0.4-0.2-0.2-0.2-0.60.7-0.5
Distance traveled after self-admin0.00.00.1-0.1-0.2-0.20.20.20.30.30.3-0.00.10.1
Extensor digitorum longus weight4.116.320.94.54.34.6-4.6-4.0-3.7-3.7-3.8-3.93.8-3.2
Bone: elastic displacement0.20.20.3-0.5-0.5-0.50.50.40.40.40.40.5-0.50.4
Bone: elastic work0.30.40.70.40.60.1-0.1-0.6-0.7-0.7-0.7-0.80.7-0.8
Bone: endosteal estimation0.20.40.70.40.60.2-0.3-0.7-0.7-0.7-0.7-0.70.7-0.9
Bone: endosteal perimeter0.30.61.4-1.0-0.8-1.21.20.60.50.50.50.6-0.60.2
Epididymis fat weight0.10.20.70.50.20.8-0.80.10.10.10.20.3-0.10.5
Delta time in closed arm before/after self-admin1.00.93.31.80.81.7-1.6-0.4-0.2-0.2-0.2-0.30.20.3
Delta time in open arm before/after self-admin0.60.60.70.50.80.8-0.7-0.8-0.8-0.8-0.8-0.70.9-0.8
Diff in mean of infusions in LGA sessions1.41.72.2-1.4-1.4-1.21.41.41.31.31.31.5-1.01.3
Delay discount exponential model param1.82.02.5-1.4-1.5-1.31.21.41.41.41.41.4-1.61.4
Extinction: sum of active levers before priming0.91.01.9-0.4-1.0-0.40.51.11.31.31.31.0-0.91.4
Active lever presses in extinction session 62.42.42.9-1.6-1.7-1.61.71.61.61.61.61.3-1.41.3
Bone: final force1.32.13.61.01.40.6-0.6-1.5-1.6-1.6-1.6-1.81.7-1.9
Bone: final moment1.11.73.00.81.20.5-0.5-1.4-1.4-1.4-1.5-1.61.5-1.7
Food consumed during 24 hour testing period0.50.71.31.20.90.8-0.8-0.8-0.8-0.8-0.8-0.80.9-0.7
Glucose2.54.04.62.12.12.1-2.1-2.0-1.9-1.9-1.8-2.12.0-1.8
Heart weight0.61.01.8-0.3-0.8-0.30.21.01.21.21.11.2-1.11.4
Delay discount hyperbolic model param3.13.54.4-1.8-1.9-1.61.51.91.91.91.91.9-2.12.0
Intermittent access intake day 1-15 change3.47.08.6-2.0-2.6-2.12.12.82.92.92.92.7-2.92.9
Intermittent access intake escalation3.06.27.7-1.9-2.5-2.02.02.62.72.72.72.5-2.82.7
Intermittent access intake escalation 24.75.46.2-1.9-2.3-2.02.02.42.52.52.52.4-2.52.5
Intermitt. access day 1 inactive lever presses0.10.51.10.5-0.30.4-0.40.61.01.01.00.5-0.71.1
Intermitt. access day 15 inactive lever presses0.20.40.6-0.7-0.7-0.70.70.60.60.60.60.7-0.80.5
Intermitt. access escalation Index0.71.01.90.40.90.3-0.3-1.1-1.2-1.2-1.2-1.20.9-1.4
Intermittent access day 1 total infusions0.10.20.40.3-0.30.0-0.00.50.60.60.60.5-0.60.7
Intermittent access day 15 total infusions2.53.84.8-1.2-1.9-1.61.62.12.22.22.22.0-2.22.1
Intermittent access terminal intake (last 3 days)1.92.53.3-0.9-1.6-1.31.31.71.81.81.81.6-1.81.7
Intermittent access total infusions1.01.22.0-0.4-1.1-0.80.81.21.31.31.31.1-1.41.2
Intermittent access day 1 locomotion1.51.93.1-0.5-1.3-0.60.61.51.61.61.61.6-1.61.8
Intermittent access day 15 total locomotion3.25.87.5-1.8-2.4-1.71.72.52.72.72.72.6-2.72.7
Intermittent access total locomotion2.53.04.0-1.0-1.7-1.21.21.82.02.02.01.8-1.92.0
Intermittent access standard deviation3.88.08.9-2.5-2.9-2.72.72.93.03.03.02.7-3.02.7
Left kidney weight0.00.10.30.40.20.6-0.60.00.20.20.10.1-0.20.4
Right kidney weight0.52.13.1-0.9-1.3-0.90.91.51.61.61.61.6-1.61.8
Cocaine induced anxiety1.01.53.3-1.8-1.3-1.71.71.10.90.90.90.9-0.80.6
Post-drug Anxiety1.11.23.1-1.8-1.2-1.51.50.90.70.70.70.9-0.40.4
Baseline Anxiety0.10.10.10.0-0.2-0.20.20.30.30.30.30.30.10.3
Tail length3.413.414.5-3.2-3.7-3.63.63.83.83.83.83.6-3.83.5
Length with tail1.98.49.0-2.8-2.9-2.72.73.03.03.03.02.9-3.02.8
Length without tail0.00.00.1-0.10.10.2-0.2-0.1-0.0-0.0-0.0-0.10.1-0.0
Times rat made contact with spout0.20.20.50.70.50.7-0.7-0.3-0.2-0.2-0.2-0.30.3-0.0
Lifetime Intake0.50.71.1-0.2-0.8-0.50.50.91.01.01.00.8-1.11.0
Liver weight, left1.01.61.91.41.31.4-1.4-1.3-1.3-1.3-1.2-1.11.3-1.1
Liver weight, right0.61.01.71.31.11.2-1.2-0.9-0.8-0.8-0.8-0.90.9-0.7
Locomotor activity3.14.88.3-2.4-2.4-2.92.92.12.02.02.01.8-1.71.5
Locomotor testing distance1.63.05.2-1.8-1.9-2.32.31.71.61.61.61.4-1.31.2
Locomotor testing rearing0.00.10.20.4-0.2-0.00.00.30.30.30.40.3-0.20.4
Locomotion in novel chamber1.21.52.2-0.8-1.2-0.80.81.31.51.51.41.1-1.21.4
Locomotion in novel chamber post-restriction1.01.62.0-0.7-1.3-1.31.41.41.31.31.31.4-1.01.3
Fecal boli incidents, locomotor time 11.31.82.81.11.41.7-1.7-1.4-1.3-1.3-1.2-1.51.3-1.0
Change in fecal boli incidents, locomotor task0.30.31.2-0.3-0.6-1.11.10.50.40.40.40.3-0.4-0.0
Time >=10cm from walls, locomotor time 10.40.41.2-0.10.50.0-0.0-0.6-0.6-0.6-0.5-1.10.6-1.0
Bouts of movement, locomotor time 10.40.40.7-0.7-0.6-0.50.50.60.70.70.70.6-0.80.7
Total resting periods, locomotor time 10.50.50.6-0.8-0.7-0.70.70.70.70.70.80.7-0.80.7
Rest time, locomotor task time 10.20.30.5-0.7-0.5-0.60.60.50.40.40.60.5-0.40.3
Distance moved, locomotor task time 10.60.81.80.50.80.2-0.2-1.0-1.0-1.0-1.1-1.20.9-1.3
Vertical activity count, locomotor time 10.10.20.80.90.50.3-0.3-0.4-0.3-0.3-0.3-0.50.3-0.3
Time >=10cm from walls, locomotor time 20.81.21.81.31.21.2-1.2-1.1-0.9-0.9-0.8-1.41.0-0.8
Bouts of movement, locomotor time 20.30.41.7-1.3-0.6-0.90.90.40.30.30.40.5-0.60.1
Total resting periods, locomotor time 20.20.41.7-1.3-0.6-0.90.90.40.30.30.30.4-0.50.0
Rest time, locomotor task time 20.60.71.4-1.2-0.9-1.11.10.80.70.70.70.7-0.70.5
Distance moved, locomotor task time 20.60.71.11.00.91.0-1.0-0.8-0.7-0.7-0.7-0.80.6-0.6
Vertical activity count, locomotor time 20.50.61.41.20.91.2-1.2-0.6-0.5-0.5-0.5-0.60.4-0.2
Light reinforcement 14.110.012.1-3.5-3.4-3.43.43.23.13.12.93.1-2.92.7
Light reinforcement 21.72.63.6-1.8-1.7-1.91.91.61.41.41.51.6-1.41.3
Bone: marrow area0.20.40.70.40.60.3-0.3-0.7-0.7-0.7-0.7-0.70.7-0.8
Bone: maximum diameter0.91.63.4-1.7-1.3-1.81.91.11.01.01.01.0-0.90.6
Bone: maximum force1.22.23.31.11.50.8-0.8-1.6-1.6-1.6-1.6-1.71.7-1.8
Bone: maximum moment1.11.92.81.01.30.7-0.7-1.4-1.5-1.5-1.5-1.61.5-1.7
Mean time between licks in bursts2.66.27.0-2.1-2.6-2.32.32.62.62.62.62.6-2.62.5
Mean num. licks in bursts0.10.10.2-0.10.2-0.00.0-0.3-0.3-0.3-0.3-0.20.4-0.4
Cd content in liver0.20.20.4-0.6-0.5-0.50.50.40.40.40.40.4-0.30.4
Co content in liver1.72.02.4-1.2-1.4-1.21.21.51.61.61.51.5-1.51.5
Cu content in liver0.30.30.9-1.0-0.5-0.90.90.30.30.30.30.2-0.3-0.1
Fe content in liver0.20.20.4-0.2-0.4-0.10.10.40.50.50.50.5-0.60.6
K content in liver0.10.10.4-0.6-0.2-0.50.50.00.00.0-0.0-0.10.1-0.3
Mg content in liver0.30.30.7-0.8-0.6-0.70.70.50.50.50.40.5-0.50.3
Mn content in liver1.61.84.7-2.0-1.4-2.22.21.00.80.80.70.8-0.90.2
Na content in liver0.91.01.70.30.90.5-0.5-1.1-1.1-1.1-1.1-1.21.1-1.3
Rb content in liver0.20.20.5-0.7-0.2-0.70.7-0.1-0.2-0.2-0.3-0.20.3-0.5
Se content in liver0.20.20.4-0.5-0.5-0.40.40.50.50.50.50.5-0.60.5
Sr content in liver0.00.00.10.30.10.3-0.3-0.00.00.00.00.0-0.00.1
Zn content in liver4.34.87.6-1.3-2.0-1.11.12.32.52.52.52.4-2.52.7
Bone: minimum diameter0.10.10.3-0.20.1-0.40.4-0.2-0.3-0.3-0.3-0.30.3-0.5
Time in familiar zone, hab. session 12.12.02.8-1.1-1.4-1.21.21.51.41.41.41.7-1.51.5
Time in novel zone, hab. session 11.11.12.00.51.00.4-0.4-1.1-1.1-1.1-1.1-1.31.2-1.4
Total zone transitions, hab. session 10.91.24.2-2.0-1.2-1.51.50.80.70.70.70.8-0.70.3
Total locomotion distance, hab. session 11.21.86.4-2.5-1.3-2.02.00.90.60.60.60.8-0.60.1
Locomotion velocity, hab. session 11.62.37.3-2.7-1.6-2.12.01.21.01.01.01.2-1.00.5
Time in familiar zone, hab. session 26.26.68.2-1.8-2.6-2.02.02.82.82.82.82.8-2.82.9
Time in novel zone, hab. session 24.74.86.51.52.21.6-1.6-2.4-2.4-2.4-2.4-2.42.4-2.6
Total zone transitions, hab. session 20.50.71.6-1.10.3-0.30.3-0.7-0.9-0.9-0.9-0.70.9-1.2
Total locomotion distance, hab. session 21.01.45.3-2.3-1.2-1.51.40.90.70.70.71.0-0.70.4
Locomotion velocity, hab. session 21.11.46.2-2.5-1.2-1.61.50.80.60.60.60.9-0.60.3
Novel to familiar place preference ratio4.14.56.61.52.11.4-1.4-2.3-2.3-2.3-2.3-2.52.4-2.6
Novelty place preference2.52.74.31.11.61.0-1.0-1.8-1.8-1.8-1.8-2.01.9-2.1
Time in novel zone, NPP test2.93.14.61.31.71.1-1.1-1.9-1.9-1.9-1.9-2.12.0-2.2
Total zone transitions, NPP test0.20.21.4-1.2-0.0-0.20.2-0.3-0.4-0.4-0.4-0.20.4-0.5
Total locomotion distance, NPP test0.20.31.3-1.1-0.0-0.40.4-0.3-0.5-0.5-0.5-0.30.4-0.7
Locomotion velocity, NPP test0.20.32.0-1.4-0.3-0.60.6-0.0-0.2-0.2-0.20.00.1-0.4
Intraocular pressure0.20.30.80.70.10.9-0.90.20.40.40.40.3-0.30.8
Delta distance traveled before/after self-admin0.30.40.5-0.6-0.6-0.60.50.60.60.60.60.7-0.70.7
Delta ambulatory time before/after self-admin0.30.40.6-0.7-0.6-0.80.60.60.50.50.50.6-0.70.5
Parametrial fat weight0.00.00.1-0.2-0.0-0.20.2-0.1-0.1-0.10.0-0.20.1-0.2
Pavlov. Cond. lever latency0.20.20.70.80.10.6-0.60.20.30.30.30.1-0.30.6
Pavlov. Cond. magazine entry latency2.93.74.2-1.9-2.0-1.81.82.01.91.91.92.0-1.91.9
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.2-0.20.20.20.20.20.20.2-0.20.1
Pavlov. Cond. index score0.40.51.1-1.1-0.7-0.90.90.60.50.50.50.7-0.50.3
Pavlov. Cond. latency score0.40.51.5-1.2-0.7-1.01.00.50.40.40.40.6-0.40.1
Pavlov. Cond. lever contacts0.10.20.4-0.6-0.0-0.50.5-0.2-0.3-0.3-0.3-0.10.3-0.6
Pavlov. Cond. magazine entry number0.70.91.20.91.00.8-0.8-1.0-0.9-0.9-0.9-1.11.0-1.0
Pavlov. Cond. intertrial magazine entries0.20.30.60.0-0.30.1-0.10.50.60.60.60.7-0.60.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.2-1.1-0.9-1.01.00.70.60.60.60.8-0.60.5
Pavlov. Cond. response bias0.70.91.2-1.0-1.0-0.90.91.00.90.90.91.1-1.00.9
Pavlov. Cond. lever latency0.81.01.30.71.01.2-1.2-1.1-1.1-1.1-1.1-0.90.9-0.9
Pavlov. Cond. magazine entry latency0.40.50.7-0.4-0.7-0.80.80.70.80.80.70.6-0.70.5
Pavlov. Cond. change in total contacts0.60.91.2-0.5-0.9-0.90.91.01.11.11.10.9-1.01.0
Pavlov. Cond. index score0.70.91.1-0.6-0.9-1.01.01.01.01.01.00.9-0.90.9
Pavlov. Cond. latency score0.70.91.3-0.7-1.0-1.11.11.01.01.01.00.8-0.90.8
Pavlov. Cond. lever contacts0.60.81.0-0.4-0.9-0.90.91.01.01.01.00.9-0.80.9
Pavlov. Cond. magazine entry number0.70.91.30.60.91.1-1.1-0.9-1.0-1.0-0.9-0.90.9-0.7
Pavlov. Cond. intertrial magazine entries0.30.40.80.70.70.9-0.9-0.5-0.5-0.5-0.5-0.40.7-0.3
Pavlov. Cond. lever-magazine prob. diff.0.71.01.3-0.7-1.0-1.11.11.01.01.01.00.9-0.90.8
Pavlov. Cond. response bias1.62.22.7-0.9-1.5-1.41.41.61.61.61.61.5-1.51.5
Time in closed arm before self-admin0.50.61.20.10.60.2-0.2-0.8-1.0-1.0-1.0-0.91.1-1.1
Time in closed arm after self-admin0.10.10.40.1-0.3-0.00.10.40.40.40.40.5-0.20.6
Time in open arm before self-admin0.20.30.5-0.2-0.5-0.70.50.50.60.60.60.2-0.70.4
Time in open arm after self-admin0.80.91.10.91.00.9-1.0-1.0-0.9-0.9-0.9-1.00.7-0.9
Bone: periosteal estimation0.30.61.50.10.6-0.10.1-0.8-0.9-0.9-0.9-0.90.9-1.2
Bone: periosteal perimeter0.20.31.1-0.8-0.4-1.01.10.20.10.10.10.0-0.1-0.3
Bone: post-yield work0.60.91.01.01.00.9-0.9-1.0-0.9-0.9-1.0-0.90.9-0.9
Progressive ratio test 1 active lever presses0.20.20.40.5-0.10.3-0.30.30.40.40.40.5-0.60.6
Progressive ratio test 1 breakpoint0.20.20.40.5-0.10.3-0.30.30.40.40.40.5-0.60.6
Progressive ratio test 1 inactive lever presses0.20.30.6-0.2-0.5-0.20.20.60.70.70.70.8-0.70.8
Progressive ratio test 2 active lever presses0.50.61.20.4-0.40.1-0.10.71.01.01.00.7-1.11.1
Progressive ratio test 2 breakpoint0.60.71.30.3-0.50.1-0.10.81.01.01.00.8-1.21.1
Progressive ratio test 2 inactive lever presses0.10.20.5-0.1-0.4-0.20.20.50.60.60.60.4-0.70.5
Incentive Sensitization - Responses0.20.30.50.60.10.7-0.70.10.40.40.40.1-0.60.6
Incentive Sensitization - Breakpoint0.20.20.50.4-0.00.6-0.50.20.50.50.50.2-0.70.6
Sum of active levers in priming session hrs 5-60.00.00.10.20.10.1-0.1-0.1-0.0-0.0-0.0-0.20.4-0.0
Progressive ratio0.30.41.50.40.71.2-1.2-0.6-0.5-0.5-0.5-0.40.2-0.1
Food seeking constrained by brief footshock0.10.10.2-0.5-0.4-0.10.20.30.30.30.30.4-0.30.4
Seeking ratio, punishment vs. effort0.20.30.9-0.6-0.6-0.90.90.50.40.40.40.5-0.20.2
Retroperitoneal fat weight0.41.94.21.61.52.1-2.0-1.2-1.1-1.1-1.0-1.01.1-0.6
Reaction time number correct0.40.72.61.60.91.3-1.3-0.6-0.4-0.4-0.5-0.30.4-0.1
Reaction time mean minus median0.30.81.2-0.6-0.9-0.80.70.91.01.01.10.9-1.00.8
Reaction time mean minus median AUC0.00.10.3-0.3-0.0-0.50.5-0.1-0.1-0.1-0.1-0.30.2-0.6
Reaction time num false alarms0.10.10.80.90.40.5-0.5-0.2-0.1-0.1-0.0-0.1-0.0-0.0
Reaction time num false alarms AUC0.10.21.01.00.50.7-0.7-0.2-0.1-0.1-0.0-0.1-0.10.1
Reaction time trials correct on left0.40.72.61.60.91.3-1.3-0.6-0.4-0.4-0.5-0.30.4-0.1
Reaction time trials on left0.40.72.51.60.91.2-1.2-0.6-0.5-0.5-0.5-0.30.4-0.1
Reaction time mean0.00.10.3-0.30.1-0.30.2-0.2-0.3-0.3-0.2-0.30.1-0.5
Reaction time mean AUC0.10.10.3-0.20.2-0.20.2-0.3-0.4-0.4-0.3-0.40.2-0.6
Median of all reaction times0.30.41.00.00.50.1-0.1-0.7-0.8-0.8-0.7-0.70.6-1.0
Reaction time omissions0.10.20.4-0.7-0.5-0.60.60.30.30.30.40.2-0.10.1
Reaction time false alarm rate0.00.00.00.20.20.1-0.1-0.2-0.1-0.1-0.0-0.20.1-0.2
Reaction time premature initiation rate1.01.31.9-0.7-1.1-0.80.81.31.21.21.41.3-1.31.4
Reaction time premature initiations0.61.02.10.1-0.8-0.20.21.11.11.11.21.2-1.21.5
Std. dev. reaction times0.10.20.3-0.5-0.4-0.50.50.40.50.50.50.3-0.50.2
Reaction time trials completed0.40.72.51.60.91.2-1.2-0.6-0.5-0.5-0.5-0.30.4-0.1
Reaction time trials AUC0.40.72.81.70.91.3-1.3-0.6-0.4-0.4-0.4-0.30.30.0
Run reversals in cocaine runway, females0.50.51.1-0.7-0.8-1.01.00.70.60.60.60.6-0.50.4
Run reversals in cocaine runway, males1.51.62.7-1.6-1.3-1.51.71.21.01.01.11.3-0.70.9
Latency to leave start box in cocaine runway0.50.61.9-0.7-0.9-1.41.20.70.70.70.60.3-0.40.2
Latency to leave start box in cocaine runway, F0.20.30.7-0.3-0.1-0.80.8-0.2-0.2-0.2-0.2-0.70.5-0.8
Latency to leave start box in cocaine runway, M2.01.82.4-0.8-1.4-1.10.91.51.51.51.51.5-1.51.5
Std. dev. time between licks in bursts0.81.12.2-1.1-1.0-1.51.50.90.80.80.80.8-1.00.5
Total sessions with >9 infusions0.30.40.60.0-0.5-0.20.20.60.80.80.80.6-0.70.8
Short access day 1 total inactive lever presses0.30.41.0-0.6-0.6-0.30.30.70.70.70.70.7-1.00.8
Short access day 10 total inactive lever presses0.10.10.20.40.00.5-0.50.20.40.40.4-0.0-0.20.5
Short access day 1 total infusions0.30.40.6-0.5-0.6-0.50.50.60.60.60.60.7-0.80.6
Short access day 10 total infusions0.10.10.30.4-0.20.2-0.20.30.40.40.40.5-0.40.5
Short access total infusions0.30.40.7-0.1-0.6-0.30.30.70.80.80.80.6-0.80.8
Short access day 1 locomotion1.41.72.1-0.8-1.3-1.11.11.41.41.41.41.4-1.31.3
Short access day 10 total locomotion4.48.210.8-1.8-2.8-2.02.03.03.23.23.23.0-3.23.3
Short access total locomotion2.42.93.9-1.0-1.7-1.31.31.82.02.02.01.7-1.71.9
One hour access (0.3 mA shock)0.00.00.10.30.10.3-0.3-0.00.00.00.00.1-0.20.1
Compulsive drug intake1.11.32.40.31.00.4-0.4-1.2-1.3-1.3-1.3-1.41.5-1.6
One hour access (shock baseline)0.40.71.4-0.0-0.7-0.30.30.80.90.90.91.1-1.21.1
Social response proportion0.80.92.2-1.5-1.0-1.11.10.90.70.70.60.9-1.00.7
Social responses7.09.011.4-3.3-3.2-3.43.43.02.92.92.82.8-2.92.5
Social time0.50.60.90.70.80.9-0.9-0.8-0.8-0.8-0.8-0.80.8-0.6
Soleus weight8.424.627.14.95.24.7-4.7-5.1-5.1-5.1-5.1-5.05.1-4.7
Bone: stiffness2.74.35.51.72.11.5-1.5-2.2-2.2-2.2-2.3-2.32.2-2.3
Tibialis anterior weight1.13.64.52.12.01.9-1.9-1.9-1.7-1.7-1.7-1.92.1-1.8
Time to tail flick, vehicle, before self-admin0.10.10.2-0.3-0.3-0.30.30.20.20.20.20.20.40.0
Time to tail flick, vehicle, after self-admin0.30.41.20.1-0.40.3-0.10.70.70.70.70.9-0.81.1
Time to tail flick, test, before self-admin0.40.41.1-0.9-0.6-1.01.00.40.30.30.30.4-0.50.1
Time to tail flick, test, after self-admin0.10.10.2-0.3-0.3-0.30.30.30.20.20.20.4-0.10.2
Delta time to tail flick, vehicle, before/after SA0.40.41.41.00.51.2-1.0-0.3-0.2-0.2-0.2-0.0-0.20.3
Delta time to tail flick, test, before/after SA0.10.10.40.50.10.6-0.60.10.20.20.20.3-0.10.5
Tibia length0.92.53.1-1.5-1.6-1.41.41.61.61.61.61.7-1.81.6
Ambulatory time before self-admin0.10.10.40.40.30.3-0.2-0.4-0.2-0.2-0.2-0.60.7-0.4
Ambulatory time after self-admin0.00.00.0-0.0-0.1-0.20.10.00.10.10.1-0.10.2-0.1
Bone: tissue strength1.91.92.41.11.41.2-1.2-1.5-1.5-1.5-1.5-1.51.4-1.5
Total heroin consumption1.41.72.1-1.3-1.4-1.41.41.31.31.31.31.3-1.01.1
Bone: trabecular number0.40.71.9-1.2-0.8-1.41.40.60.40.40.40.5-0.40.0
Bone: trabecular spacing0.60.82.81.60.81.6-1.7-0.4-0.1-0.1-0.1-0.10.10.4
Bone: trabecular thickness0.81.02.2-1.2-0.1-1.51.5-0.5-0.7-0.7-0.7-0.90.7-1.5
Bone: trabecular tissue density1.31.92.81.41.51.7-1.7-1.4-1.3-1.3-1.3-1.41.3-1.0
Water consumed over 24 hours0.71.01.70.90.90.5-0.5-1.0-1.1-1.1-1.1-1.11.3-1.2
Number of responses in last shaping day1.61.82.4-0.7-1.3-0.91.01.51.51.51.51.5-1.41.5