Hub : Genes

Ap3d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Ap3d1 0.38 0.22 1.2e-03 0.04 0.02 0.05 0.04 4.2e-03 3.3e-02 1.5e-03 1.9e-03
2 Liver gene expression Ap3d1 0.09 0.06 2.8e-11 0.08 0.09 0.09 0.09 2.2e-09 1.4e-10 4.4e-10 3.1e-10
3 NAcc gene expression Ap3d1 0.03 0.04 2.3e-03 0.02 0.02 0.01 0.02 7.2e-04 1.4e-03 3.0e-03 9.0e-04
4 pVTA mRNA stability Ap3d1 0.09 0.06 2.2e-07 0.06 0.07 0.07 0.07 8.9e-06 1.6e-06 2.4e-06 1.5e-06
5 NAcc mRNA stability Ap3d1 0.07 0.04 8.5e-15 0.1 0.1 0.1 0.1 2.7e-14 1.6e-14 2.4e-14 3.0e-14
6 LHb mRNA stability Ap3d1 0.15 0.1 9.0e-04 0.13 0.1 0.12 0.11 4.9e-04 2.0e-03 9.7e-04 1.6e-03
7 Liver intron excision ratio chr7_9650697_9651063 0.03 0.03 1.3e-04 0.03 0.03 0.03 0.03 1.2e-04 1.9e-04 1.4e-04 1.2e-04
8 Liver mRNA stability Ap3d1 0.03 0.03 1.1e-04 0.03 0.03 0.02 0.03 1.2e-04 1.9e-04 1.5e-03 2.6e-04
9 Brain mRNA stability Ap3d1 0.13 0.07 2.3e-15 0.15 0.14 0.15 0.14 7.6e-14 2.3e-13 1.2e-13 3.8e-13
10 Adipose gene expression Ap3d1 0.18 0.11 0.0e+00 0.18 0.17 0.19 0.18 4.3e-20 6.4e-19 3.1e-20 1.4e-19
11 PL mRNA stability Ap3d1 0.13 0.09 1.1e-13 0.12 0.12 0.12 0.12 4.8e-13 2.2e-13 6.8e-13 3.3e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.30.61.50.70.10.90.9-0.50.7-0.70.70.7-0.7-1.2
Area under the delay curve1.62.43.0-1.51.6-1.4-1.3-1.61.6-1.61.61.6-1.7-1.6
BMI with tail6.422.426.5-4.84.9-5.1-5.1-4.84.6-4.64.74.6-4.6-4.1
BMI without tail1.16.18.7-2.92.6-2.8-2.8-2.42.3-2.32.32.4-2.2-1.9
Body weight0.94.04.9-1.92.1-2.2-2.2-2.01.9-1.92.02.1-1.9-1.7
Weight adjusted by age0.10.41.0-1.00.7-0.8-0.8-0.50.5-0.50.50.5-0.3-0.3
Bone surface0.61.13.81.6-0.62.02.00.00.4-0.40.30.2-0.4-1.1
Bone volume0.61.13.91.5-0.52.02.0-0.00.4-0.40.30.4-0.4-1.2
Breakpoint value in progressive ratio session2.34.25.01.6-2.21.61.82.2-2.22.2-2.2-2.21.82.2
Number of licking bursts0.10.20.5-0.70.2-0.6-0.60.1-0.20.2-0.2-0.10.30.5
Context. condit. distance diff. score0.30.40.5-0.70.7-0.7-0.7-0.70.6-0.60.60.7-0.6-0.6
Locomotion velocity, session 10.50.62.21.5-0.81.11.10.5-0.50.5-0.5-0.30.40.1
Locomotion distance, session 10.30.42.31.5-0.40.90.90.10.1-0.10.10.1-0.1-0.5
Locomotion velocity, session 23.54.110.33.2-2.22.62.61.8-1.61.6-1.6-1.71.51.1
Locomotion distance, session 21.72.37.32.7-1.62.12.11.2-1.01.0-1.0-1.11.00.5
Locomotion velocity, session 36.06.97.82.4-2.72.52.52.7-2.72.7-2.7-2.82.62.5
Locomotion distance, session 30.00.00.0-0.20.0-0.1-0.10.0-0.10.1-0.1-0.10.00.1
Stereotopy head waving bouts, day 34.65.57.32.7-2.52.52.52.3-2.22.2-2.2-2.52.21.9
Stereotopy head waving duration, day 35.66.98.62.9-2.82.72.72.7-2.52.5-2.5-2.92.52.3
Locomotion velocity, session 70.50.61.00.5-0.71.01.00.8-0.80.8-0.8-0.60.80.5
Locomotion distance, session 70.20.21.0-1.00.5-0.7-0.7-0.30.1-0.10.10.3-0.20.0
Stereotopy head waving bouts, day 70.10.20.40.60.00.40.4-0.20.4-0.40.40.1-0.4-0.7
Stereotopy head waving duration, day 70.40.41.61.3-0.61.11.10.4-0.20.2-0.2-0.40.2-0.2
Locomotion velocity, session 80.60.72.91.7-0.81.41.40.5-0.30.3-0.3-0.30.3-0.1
Locomotion distance, session 80.10.20.91.0-0.40.60.60.3-0.20.2-0.2-0.10.20.0
Degree of sensitization distance0.40.50.8-0.70.7-0.6-0.6-0.70.7-0.70.70.9-0.7-0.7
Degree of sensitization stereotypy1.71.92.9-0.81.3-0.9-0.9-1.51.5-1.51.51.5-1.6-1.7
Conditioned locomotion1.21.43.0-1.51.3-1.7-1.7-1.11.0-1.01.00.9-0.8-0.5
Cocaine response after cond. corrected3.95.99.2-3.02.6-3.0-3.0-2.32.1-2.12.12.2-2.1-1.7
Cocaine response after cond. not corrected4.36.210.1-3.22.7-3.0-3.0-2.42.2-2.22.22.2-2.1-1.7
Cocaine response before conditioning0.40.51.00.7-0.81.01.00.7-0.60.6-0.7-0.70.50.5
Saline control response0.10.20.5-0.70.4-0.7-0.7-0.30.2-0.20.10.3-0.5-0.0
Bone: connectivity density0.40.61.70.10.50.20.2-0.81.0-1.01.00.9-0.9-1.3
Bone: cortical apparent density0.71.11.5-1.01.1-0.9-0.9-1.11.1-1.11.11.0-1.2-1.1
Bone: cortical area0.40.71.7-0.20.70.00.1-0.91.0-1.01.01.1-1.0-1.3
Bone: cortical porosity0.20.20.60.8-0.40.80.80.3-0.20.2-0.2-0.00.3-0.0
Bone: cortical porosity0.20.20.50.7-0.10.70.7-0.10.2-0.20.20.4-0.2-0.5
Bone: cortical thickness1.01.72.5-0.91.3-0.7-0.7-1.41.4-1.41.51.5-1.5-1.6
Bone: cortical thickness0.10.10.3-0.4-0.1-0.3-0.20.3-0.40.4-0.4-0.40.40.6
Bone: cortical tissue density0.50.81.0-0.80.9-0.7-0.7-0.90.9-0.90.90.8-1.0-0.9
Condit. Reinf. active minus inactive responses4.14.65.62.2-2.22.02.12.2-2.22.2-2.2-2.42.12.0
Condit. Reinf. active-inactive response ratio2.22.32.91.1-1.51.11.21.6-1.71.7-1.7-1.71.61.7
Condit. Reinf. active responses3.44.47.42.7-2.32.32.32.0-1.91.9-1.9-2.11.91.6
Condit. Reinf. inactive responses0.70.93.01.7-1.11.41.40.8-0.60.6-0.6-0.40.60.3
Incentive salience index mean2.12.64.32.1-1.71.81.91.6-1.51.5-1.5-1.61.41.2
Condit. Reinf. lever presses0.20.31.21.1-0.30.70.8-0.10.2-0.20.20.2-0.3-0.6
Condit. Reinf. active minus inactive responses2.03.14.21.2-1.71.31.31.9-2.02.0-2.0-1.91.92.0
Condit. Reinf. active-inactive response ratio0.20.30.9-0.3-0.2-0.5-0.50.5-0.70.7-0.7-0.50.71.0
Condit. Reinf. active responses2.33.34.01.4-1.81.71.71.9-1.91.9-2.0-1.91.71.8
Condit. Reinf. inactive responses1.01.42.31.0-1.21.51.51.2-1.21.2-1.2-1.20.90.9
Condit. Reinf. lever presses1.82.63.21.1-1.61.31.31.7-1.81.8-1.8-1.71.61.8
Condit. Reinf. lever reinforcers received1.72.43.21.0-1.51.31.31.7-1.71.7-1.8-1.71.51.7
Conditioned reinforcement - actives0.51.83.60.6-1.20.80.81.4-1.51.5-1.5-1.31.91.6
Conditioned reinforcement - inactives0.00.10.2-0.40.2-0.5-0.5-0.0-0.00.0-0.0-0.10.20.2
Conditioned locomotion6.79.911.42.7-3.33.03.03.3-3.43.4-3.4-3.03.13.0
Patch foraging indifference point 0 sec0.10.30.5-0.30.5-0.2-0.2-0.60.7-0.70.60.7-0.6-0.7
Patch foraging indifference point AUC0.61.31.80.9-1.10.80.81.2-1.31.3-1.3-1.11.31.3
Delay disc. indifference point, 0s delay7.78.712.1-1.92.9-2.1-2.1-3.23.3-3.33.23.3-3.1-3.5
Delay disc. indifference point, 16s delay0.10.20.5-0.40.4-0.3-0.2-0.50.4-0.40.50.3-0.7-0.5
Delay disc. indifference point, 2s delay6.47.28.9-2.22.7-2.1-2.2-2.82.9-2.92.82.8-3.0-2.9
Delay disc. indifference point, 24s delay0.40.61.2-1.10.8-0.9-0.8-0.70.6-0.60.70.8-0.8-0.6
Delay disc. indifference point, 4s delay1.41.52.3-1.11.2-0.7-0.7-1.31.3-1.31.41.1-1.5-1.5
Delay disc. indifference point, 8s delay0.71.21.7-1.31.2-1.3-1.2-1.11.0-1.01.01.2-1.0-0.9
Indifference point function ln k0.10.20.6-0.80.5-0.3-0.3-0.40.4-0.40.40.3-0.5-0.4
Indifference point function log k0.10.20.6-0.80.5-0.3-0.3-0.40.4-0.40.40.3-0.5-0.4
Patch foraging total patch changes 0 sec0.10.20.4-0.30.4-0.2-0.2-0.50.6-0.60.50.6-0.5-0.6
Patch foraging total patch changes 12 sec0.40.51.3-0.90.7-1.1-1.2-0.60.6-0.60.50.7-0.4-0.2
Patch foraging total patch changes 18 sec0.51.11.31.1-1.11.11.11.1-1.11.1-1.1-0.91.01.0
Patch foraging total patch changes 24 sec0.00.10.20.4-0.30.30.30.3-0.20.2-0.2-0.10.10.2
Patch foraging total patch changes 6 sec0.20.30.70.8-0.60.60.70.5-0.40.4-0.5-0.30.60.3
Patch foraging time to switch 0 sec0.62.43.8-0.31.3-0.7-0.8-1.61.9-1.91.81.7-1.7-1.9
Patch foraging water rate 0 sec0.10.41.0-1.00.0-0.6-0.60.3-0.60.6-0.7-0.40.60.8
Patch foraging water rate 12 sec0.41.54.3-2.11.3-1.8-1.8-0.90.7-0.70.70.8-0.7-0.3
Patch foraging water rate 18 sec0.41.02.4-1.2-0.1-1.0-1.00.7-1.01.0-1.0-0.90.81.5
Patch foraging water rate 24 sec0.71.03.4-1.90.7-1.8-1.8-0.2-0.10.1-0.20.10.10.6
Patch foraging water rate 6 sec0.60.82.0-0.4-0.5-0.1-0.10.9-1.21.2-1.1-1.01.01.4
Seeking ratio, delayed vs. immediate footshock3.34.76.32.1-2.32.52.42.2-2.22.2-2.2-2.11.71.8
Distance traveled before self-admin0.10.20.5-0.40.3-0.2-0.1-0.40.2-0.20.20.6-0.7-0.5
Distance traveled after self-admin0.00.00.10.1-0.20.20.20.2-0.30.3-0.30.0-0.10.1
Extensor digitorum longus weight4.116.320.9-4.54.3-4.6-4.6-4.03.7-3.73.83.9-3.8-3.2
Bone: elastic displacement0.20.20.30.5-0.50.50.50.4-0.40.4-0.4-0.50.50.4
Bone: elastic work0.30.40.7-0.40.6-0.1-0.1-0.60.7-0.70.70.8-0.7-0.8
Bone: endosteal estimation0.20.40.7-0.40.6-0.2-0.3-0.70.7-0.70.70.7-0.7-0.9
Bone: endosteal perimeter0.20.61.41.0-0.81.21.20.6-0.50.5-0.5-0.60.60.2
Epididymis fat weight0.00.20.7-0.50.2-0.8-0.80.1-0.10.1-0.2-0.30.10.5
Delta time in closed arm before/after self-admin1.00.93.3-1.80.8-1.7-1.6-0.40.2-0.20.20.3-0.20.3
Delta time in open arm before/after self-admin0.50.60.7-0.40.8-0.8-0.7-0.80.8-0.80.80.7-0.9-0.8
Diff in mean of infusions in LGA sessions1.01.72.21.4-1.41.21.41.4-1.31.3-1.3-1.51.01.3
Delay discount exponential model param1.42.02.51.4-1.51.31.21.4-1.41.4-1.4-1.41.61.4
Extinction: sum of active levers before priming0.71.01.90.4-1.00.40.51.1-1.31.3-1.3-1.00.91.4
Active lever presses in extinction session 62.42.42.91.6-1.71.61.71.6-1.61.6-1.6-1.31.41.3
Bone: final force1.32.13.6-1.01.4-0.6-0.6-1.51.6-1.61.61.8-1.7-1.9
Bone: final moment1.11.73.0-0.81.2-0.5-0.5-1.41.4-1.41.51.6-1.5-1.7
Food consumed during 24 hour testing period0.30.71.3-1.20.9-0.8-0.8-0.80.8-0.80.80.8-0.9-0.7
Glucose2.54.04.6-2.12.1-2.1-2.1-2.01.9-1.91.82.1-2.0-1.8
Heart weight0.61.01.80.3-0.80.30.21.0-1.21.2-1.1-1.21.11.4
Delay discount hyperbolic model param2.73.54.41.8-1.91.61.51.9-1.91.9-1.9-1.92.12.0
Intermittent access intake day 1-15 change1.37.08.62.0-2.62.12.12.8-2.92.9-2.9-2.72.92.9
Intermittent access intake escalation1.16.27.71.9-2.52.02.02.6-2.72.7-2.7-2.52.82.7
Intermittent access intake escalation 23.25.46.21.9-2.32.02.02.4-2.52.5-2.5-2.42.52.5
Intermitt. access day 1 inactive lever presses0.00.51.1-0.5-0.3-0.4-0.40.6-1.01.0-1.0-0.50.71.1
Intermitt. access day 15 inactive lever presses0.10.40.60.7-0.70.70.70.6-0.60.6-0.6-0.70.80.5
Intermitt. access escalation Index0.31.01.9-0.40.9-0.3-0.3-1.11.2-1.21.21.2-0.9-1.4
Intermittent access day 1 total infusions0.10.20.4-0.3-0.3-0.0-0.00.5-0.60.6-0.6-0.50.60.7
Intermittent access day 15 total infusions1.53.84.81.2-1.91.61.62.1-2.22.2-2.2-2.02.22.1
Intermittent access terminal intake (last 3 days)1.42.53.30.9-1.61.31.31.7-1.81.8-1.8-1.61.81.7
Intermittent access total infusions1.01.22.00.4-1.10.80.81.2-1.31.3-1.3-1.11.41.2
Intermittent access day 1 locomotion1.01.93.10.5-1.30.60.61.5-1.61.6-1.6-1.61.61.8
Intermittent access day 15 total locomotion1.55.87.51.8-2.41.71.72.5-2.72.7-2.7-2.62.72.7
Intermittent access total locomotion2.53.04.01.0-1.71.21.21.8-2.02.0-2.0-1.81.92.0
Intermittent access standard deviation1.58.08.92.5-2.92.72.72.9-3.03.0-3.0-2.73.02.7
Left kidney weight0.00.10.3-0.40.2-0.6-0.60.0-0.20.2-0.1-0.10.20.4
Right kidney weight0.32.13.10.9-1.30.90.91.5-1.61.6-1.6-1.61.61.8
Cocaine induced anxiety0.51.53.31.8-1.31.71.71.1-0.90.9-0.9-0.90.80.6
Post-drug Anxiety1.01.23.11.8-1.21.51.50.9-0.70.7-0.7-0.90.40.4
Baseline Anxiety0.00.10.1-0.0-0.20.20.20.3-0.30.3-0.3-0.3-0.10.3
Tail length2.513.414.53.2-3.73.63.63.8-3.83.8-3.8-3.63.83.5
Length with tail1.98.49.02.8-2.92.72.73.0-3.03.0-3.0-2.93.02.8
Length without tail0.00.00.10.10.1-0.2-0.2-0.10.0-0.00.00.1-0.1-0.0
Times rat made contact with spout0.20.20.5-0.70.5-0.7-0.7-0.30.2-0.20.20.3-0.3-0.0
Lifetime Intake0.50.71.10.2-0.80.50.50.9-1.01.0-1.0-0.81.11.0
Liver weight, left0.91.61.9-1.41.3-1.4-1.4-1.31.3-1.31.21.1-1.3-1.1
Liver weight, right0.61.01.7-1.31.1-1.2-1.2-0.90.8-0.80.80.9-0.9-0.7
Locomotor activity3.14.88.32.4-2.42.92.92.1-2.02.0-2.0-1.81.71.5
Locomotor testing distance1.23.05.21.8-1.92.32.31.7-1.61.6-1.6-1.41.31.2
Locomotor testing rearing0.00.10.2-0.4-0.20.00.00.3-0.30.3-0.4-0.30.20.4
Locomotion in novel chamber1.11.52.20.8-1.20.80.81.3-1.51.5-1.4-1.11.21.4
Locomotion in novel chamber post-restriction0.51.62.00.6-1.31.31.41.4-1.31.3-1.3-1.41.01.3
Fecal boli incidents, locomotor time 10.71.82.8-1.11.4-1.7-1.7-1.41.3-1.31.21.5-1.3-1.0
Change in fecal boli incidents, locomotor task0.30.31.20.3-0.61.11.10.5-0.40.4-0.4-0.30.4-0.0
Time >=10cm from walls, locomotor time 10.30.41.20.10.5-0.0-0.0-0.60.6-0.60.51.1-0.6-1.0
Bouts of movement, locomotor time 10.30.40.70.7-0.60.50.50.6-0.70.7-0.7-0.60.80.7
Total resting periods, locomotor time 10.50.50.60.8-0.70.70.70.7-0.70.7-0.8-0.70.80.7
Rest time, locomotor task time 10.20.30.50.7-0.50.60.60.5-0.40.4-0.6-0.50.40.3
Distance moved, locomotor task time 10.30.81.8-0.40.8-0.2-0.2-1.01.0-1.01.11.2-0.9-1.3
Vertical activity count, locomotor time 10.00.20.8-0.90.5-0.3-0.3-0.40.3-0.30.30.5-0.3-0.3
Time >=10cm from walls, locomotor time 20.41.21.8-1.31.2-1.2-1.2-1.10.9-0.90.81.4-1.0-0.8
Bouts of movement, locomotor time 20.10.41.71.3-0.60.90.90.4-0.30.3-0.4-0.50.60.1
Total resting periods, locomotor time 20.10.41.71.3-0.60.90.90.4-0.30.3-0.3-0.40.50.0
Rest time, locomotor task time 20.40.71.41.2-0.91.11.10.8-0.70.7-0.7-0.70.70.5
Distance moved, locomotor task time 20.50.71.1-1.00.9-1.0-1.0-0.80.7-0.70.70.8-0.6-0.6
Vertical activity count, locomotor time 20.30.61.4-1.20.9-1.2-1.2-0.60.5-0.50.50.6-0.4-0.2
Light reinforcement 12.210.012.13.5-3.43.43.43.2-3.13.1-2.9-3.12.92.7
Light reinforcement 21.22.63.61.8-1.71.91.91.6-1.41.4-1.5-1.61.41.3
Bone: marrow area0.20.40.7-0.40.6-0.3-0.3-0.70.7-0.70.70.7-0.7-0.8
Bone: maximum diameter0.81.63.41.7-1.31.81.91.1-1.01.0-1.0-1.00.90.6
Bone: maximum force1.12.23.3-1.11.5-0.8-0.8-1.61.6-1.61.61.7-1.7-1.8
Bone: maximum moment1.01.82.8-1.01.3-0.7-0.7-1.41.5-1.51.51.6-1.5-1.7
Mean time between licks in bursts1.06.27.02.1-2.62.32.32.6-2.62.6-2.6-2.62.62.5
Mean num. licks in bursts0.00.10.20.10.20.00.0-0.30.3-0.30.30.2-0.4-0.4
Cd content in liver0.20.20.40.6-0.50.50.50.4-0.40.4-0.4-0.40.30.4
Co content in liver1.72.02.41.2-1.41.21.21.5-1.61.6-1.5-1.51.51.5
Cu content in liver0.30.30.91.0-0.50.90.90.3-0.30.3-0.3-0.20.3-0.1
Fe content in liver0.20.20.40.2-0.40.10.10.4-0.50.5-0.5-0.50.60.6
K content in liver0.10.10.40.7-0.20.50.50.0-0.00.00.00.1-0.1-0.3
Mg content in liver0.30.30.70.8-0.60.70.70.5-0.50.5-0.4-0.50.50.3
Mn content in liver1.61.84.72.0-1.42.22.21.0-0.80.8-0.7-0.80.90.2
Na content in liver0.81.01.7-0.30.9-0.5-0.5-1.11.1-1.11.11.2-1.1-1.3
Rb content in liver0.20.20.50.7-0.20.70.7-0.10.2-0.20.30.2-0.3-0.5
Se content in liver0.20.20.40.5-0.50.40.40.5-0.50.5-0.5-0.50.60.5
Sr content in liver0.00.00.1-0.30.1-0.3-0.3-0.0-0.00.0-0.0-0.00.00.1
Zn content in liver4.14.87.61.3-2.01.11.12.3-2.52.5-2.5-2.42.52.7
Bone: minimum diameter0.10.10.30.20.10.40.4-0.20.3-0.30.30.3-0.3-0.5
Time in familiar zone, hab. session 11.82.02.81.1-1.41.21.21.5-1.41.4-1.4-1.71.51.5
Time in novel zone, hab. session 11.01.12.0-0.51.0-0.4-0.4-1.11.1-1.11.11.3-1.2-1.4
Total zone transitions, hab. session 10.91.24.22.1-1.21.51.50.8-0.70.7-0.7-0.80.70.3
Total locomotion distance, hab. session 11.21.86.52.5-1.32.02.00.9-0.60.6-0.6-0.80.60.1
Locomotion velocity, hab. session 11.62.37.32.7-1.62.12.01.2-1.01.0-1.0-1.21.00.5
Time in familiar zone, hab. session 25.86.68.21.8-2.62.02.02.8-2.82.8-2.8-2.82.82.9
Time in novel zone, hab. session 24.44.86.5-1.52.2-1.6-1.6-2.42.4-2.42.42.4-2.4-2.6
Total zone transitions, hab. session 20.50.71.61.10.30.30.3-0.70.9-0.90.90.7-0.9-1.2
Total locomotion distance, hab. session 21.01.45.32.3-1.21.51.40.9-0.70.7-0.7-1.00.70.4
Locomotion velocity, hab. session 21.11.46.22.5-1.21.61.50.8-0.60.6-0.6-0.90.60.3
Novel to familiar place preference ratio3.54.56.6-1.52.1-1.4-1.4-2.32.3-2.32.32.5-2.4-2.6
Novelty place preference2.12.74.3-1.11.6-1.0-1.0-1.81.8-1.81.82.0-1.9-2.1
Time in novel zone, NPP test2.63.14.6-1.31.7-1.1-1.1-1.91.9-1.91.92.1-2.0-2.2
Total zone transitions, NPP test0.20.21.41.2-0.00.20.2-0.30.4-0.40.40.2-0.4-0.5
Total locomotion distance, NPP test0.20.31.31.1-0.00.40.4-0.30.5-0.50.50.3-0.4-0.7
Locomotion velocity, NPP test0.20.32.01.4-0.30.60.6-0.00.2-0.20.2-0.0-0.1-0.4
Intraocular pressure0.20.30.8-0.70.1-0.9-0.90.2-0.40.4-0.4-0.30.30.8
Delta distance traveled before/after self-admin0.30.40.50.6-0.60.60.50.6-0.60.6-0.6-0.70.70.7
Delta ambulatory time before/after self-admin0.20.40.60.7-0.60.80.60.6-0.50.5-0.5-0.60.70.5
Parametrial fat weight0.00.00.10.2-0.00.20.2-0.10.1-0.1-0.00.2-0.1-0.2
Pavlov. Cond. lever latency0.20.20.7-0.80.1-0.6-0.60.2-0.30.3-0.3-0.10.30.6
Pavlov. Cond. magazine entry latency2.93.74.21.9-2.01.81.82.0-1.91.9-1.9-2.01.91.9
Pavlov. Cond. change in total contacts0.00.00.10.3-0.20.20.20.2-0.20.2-0.2-0.20.20.1
Pavlov. Cond. index score0.40.51.21.1-0.70.90.90.6-0.50.5-0.5-0.70.50.3
Pavlov. Cond. latency score0.40.51.51.2-0.71.01.00.5-0.40.4-0.4-0.60.40.1
Pavlov. Cond. lever contacts0.10.20.40.7-0.00.50.5-0.20.3-0.30.30.1-0.3-0.6
Pavlov. Cond. magazine entry number0.70.91.2-0.91.0-0.8-0.8-1.00.9-0.90.91.1-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.0-0.3-0.1-0.10.5-0.60.6-0.6-0.70.60.8
Pavlov. Cond. lever-magazine prob. diff.0.50.61.21.1-0.91.01.00.7-0.60.6-0.6-0.80.60.5
Pavlov. Cond. response bias0.70.91.21.0-1.00.90.91.0-0.90.9-0.9-1.11.00.9
Pavlov. Cond. lever latency0.71.01.3-0.71.0-1.2-1.2-1.11.1-1.11.10.9-0.9-0.9
Pavlov. Cond. magazine entry latency0.30.50.70.4-0.70.80.80.7-0.80.8-0.7-0.60.70.5
Pavlov. Cond. change in total contacts0.40.91.20.5-0.90.90.91.0-1.11.1-1.1-0.91.01.0
Pavlov. Cond. index score0.60.91.10.6-0.91.01.01.0-1.01.0-1.0-0.90.90.9
Pavlov. Cond. latency score0.60.91.30.7-1.01.11.11.0-1.01.0-1.0-0.80.90.8
Pavlov. Cond. lever contacts0.50.81.00.4-0.90.90.91.0-1.01.0-1.0-0.90.80.9
Pavlov. Cond. magazine entry number0.70.91.3-0.60.9-1.1-1.1-0.91.0-1.00.90.9-0.9-0.7
Pavlov. Cond. intertrial magazine entries0.20.40.8-0.70.7-0.9-0.9-0.50.5-0.50.50.4-0.7-0.3
Pavlov. Cond. lever-magazine prob. diff.0.61.01.30.7-1.01.11.11.0-1.01.0-1.0-0.90.90.8
Pavlov. Cond. response bias1.62.22.70.9-1.51.41.41.6-1.61.6-1.6-1.51.51.5
Time in closed arm before self-admin0.40.61.2-0.10.6-0.2-0.2-0.81.0-1.01.00.9-1.1-1.1
Time in closed arm after self-admin0.10.10.4-0.1-0.30.00.10.4-0.40.4-0.4-0.50.20.6
Time in open arm before self-admin0.20.30.50.2-0.50.70.50.5-0.60.6-0.6-0.20.70.4
Time in open arm after self-admin0.80.91.1-0.91.0-0.9-1.0-1.00.9-0.90.91.0-0.7-0.9
Bone: periosteal estimation0.30.61.5-0.10.60.10.1-0.80.9-0.90.90.9-0.9-1.2
Bone: periosteal perimeter0.10.31.10.8-0.41.01.10.2-0.10.1-0.1-0.00.1-0.3
Bone: post-yield work0.50.91.0-1.01.0-0.9-0.9-1.00.9-0.91.00.9-0.9-0.9
Progressive ratio test 1 active lever presses0.10.20.4-0.5-0.1-0.3-0.30.3-0.40.4-0.4-0.50.60.6
Progressive ratio test 1 breakpoint0.10.20.4-0.5-0.1-0.3-0.30.3-0.40.4-0.4-0.50.60.6
Progressive ratio test 1 inactive lever presses0.10.30.60.2-0.50.20.20.6-0.70.7-0.7-0.80.70.8
Progressive ratio test 2 active lever presses0.40.61.2-0.4-0.4-0.1-0.10.7-1.01.0-1.0-0.71.11.1
Progressive ratio test 2 breakpoint0.50.71.3-0.3-0.5-0.1-0.10.8-1.01.0-1.0-0.81.21.1
Progressive ratio test 2 inactive lever presses0.10.20.50.1-0.40.20.20.5-0.60.6-0.6-0.40.70.5
Incentive Sensitization - Responses0.10.30.5-0.60.1-0.7-0.70.1-0.40.4-0.4-0.10.60.6
Incentive Sensitization - Breakpoint0.10.20.5-0.4-0.0-0.6-0.50.2-0.50.5-0.5-0.20.70.6
Sum of active levers in priming session hrs 5-60.00.00.1-0.20.1-0.1-0.1-0.10.0-0.00.00.2-0.4-0.0
Progressive ratio0.10.41.5-0.40.7-1.2-1.2-0.60.5-0.50.50.4-0.2-0.1
Food seeking constrained by brief footshock0.10.10.20.5-0.40.10.20.3-0.30.3-0.3-0.40.30.4
Seeking ratio, punishment vs. effort0.10.30.90.6-0.60.90.90.5-0.40.4-0.4-0.50.20.2
Retroperitoneal fat weight0.41.94.2-1.61.5-2.1-2.0-1.21.1-1.11.01.0-1.1-0.6
Reaction time number correct0.20.72.6-1.60.9-1.3-1.3-0.60.4-0.40.50.3-0.4-0.1
Reaction time mean minus median0.10.81.20.6-0.90.80.70.9-1.01.0-1.1-0.91.00.8
Reaction time mean minus median AUC0.00.10.30.3-0.00.50.5-0.10.1-0.10.10.3-0.2-0.6
Reaction time num false alarms0.10.10.8-0.90.4-0.5-0.5-0.20.1-0.10.00.10.0-0.0
Reaction time num false alarms AUC0.10.21.0-1.00.5-0.7-0.7-0.20.1-0.10.00.10.10.1
Reaction time trials correct on left0.20.72.6-1.60.9-1.3-1.3-0.60.4-0.40.50.3-0.4-0.1
Reaction time trials on left0.20.72.5-1.60.9-1.2-1.2-0.60.5-0.50.50.3-0.4-0.1
Reaction time mean0.00.10.30.30.10.30.2-0.20.3-0.30.20.3-0.1-0.5
Reaction time mean AUC0.00.10.30.20.20.20.2-0.30.4-0.40.30.4-0.2-0.6
Median of all reaction times0.30.41.0-0.00.5-0.1-0.1-0.70.8-0.80.70.7-0.6-1.0
Reaction time omissions0.10.20.40.7-0.50.60.60.3-0.30.3-0.4-0.20.10.1
Reaction time false alarm rate0.00.00.0-0.20.2-0.1-0.1-0.20.1-0.10.00.2-0.1-0.2
Reaction time premature initiation rate0.91.31.90.7-1.10.80.81.3-1.21.2-1.4-1.31.31.4
Reaction time premature initiations0.31.02.1-0.1-0.80.20.21.1-1.11.1-1.2-1.21.21.5
Std. dev. reaction times0.10.20.30.5-0.40.50.50.4-0.50.5-0.5-0.30.50.2
Reaction time trials completed0.20.72.5-1.60.9-1.2-1.2-0.60.5-0.50.50.3-0.4-0.1
Reaction time trials AUC0.20.72.8-1.70.9-1.3-1.3-0.60.4-0.40.40.3-0.30.0
Run reversals in cocaine runway, females0.50.51.10.7-0.81.01.00.7-0.60.6-0.6-0.60.50.4
Run reversals in cocaine runway, males1.41.62.71.6-1.31.51.71.2-1.01.0-1.1-1.30.70.9
Latency to leave start box in cocaine runway0.40.61.90.7-0.91.41.20.7-0.70.7-0.6-0.30.40.2
Latency to leave start box in cocaine runway, F0.20.30.70.3-0.10.80.8-0.20.2-0.20.20.7-0.5-0.8
Latency to leave start box in cocaine runway, M1.91.82.40.8-1.41.10.91.5-1.51.5-1.5-1.51.51.5
Std. dev. time between licks in bursts0.61.12.21.1-1.01.51.50.9-0.80.8-0.8-0.81.00.5
Total sessions with >9 infusions0.30.40.6-0.0-0.50.20.20.6-0.80.8-0.8-0.60.70.8
Short access day 1 total inactive lever presses0.20.41.00.6-0.60.30.30.7-0.70.7-0.7-0.71.00.8
Short access day 10 total inactive lever presses0.00.10.2-0.40.0-0.5-0.50.2-0.40.4-0.40.00.20.5
Short access day 1 total infusions0.20.40.60.5-0.60.50.50.6-0.60.6-0.6-0.70.80.6
Short access day 10 total infusions0.10.10.3-0.4-0.2-0.2-0.20.3-0.40.4-0.4-0.50.40.5
Short access total infusions0.30.40.70.1-0.60.30.30.7-0.80.8-0.8-0.60.80.8
Short access day 1 locomotion1.01.72.10.8-1.31.11.11.4-1.41.4-1.4-1.41.31.3
Short access day 10 total locomotion2.08.210.81.8-2.82.02.03.0-3.23.2-3.2-3.03.23.3
Short access total locomotion1.92.93.91.0-1.71.31.31.8-2.02.0-2.0-1.71.71.9
One hour access (0.3 mA shock)0.00.00.1-0.30.1-0.3-0.3-0.0-0.00.0-0.0-0.10.20.1
Compulsive drug intake0.91.32.4-0.31.0-0.4-0.4-1.21.3-1.31.31.4-1.5-1.6
One hour access (shock baseline)0.30.71.40.0-0.70.30.30.8-0.90.9-0.9-1.11.21.1
Social response proportion0.70.92.21.5-1.01.11.10.9-0.70.7-0.6-0.91.00.7
Social responses6.99.011.43.3-3.23.43.43.0-2.92.9-2.8-2.82.92.5
Social time0.40.60.9-0.70.8-0.9-0.9-0.80.8-0.80.80.8-0.8-0.6
Soleus weight8.424.627.1-4.85.2-4.7-4.7-5.15.1-5.15.15.0-5.1-4.7
Bone: stiffness2.44.35.5-1.72.1-1.5-1.5-2.22.2-2.22.32.3-2.2-2.3
Tibialis anterior weight1.03.64.5-2.12.0-1.9-1.9-1.91.7-1.71.71.9-2.1-1.8
Time to tail flick, vehicle, before self-admin0.10.10.20.3-0.30.30.30.2-0.20.2-0.2-0.2-0.40.0
Time to tail flick, vehicle, after self-admin0.20.41.2-0.1-0.4-0.3-0.10.7-0.70.7-0.7-0.90.81.1
Time to tail flick, test, before self-admin0.30.41.10.9-0.61.01.00.4-0.30.3-0.3-0.40.50.1
Time to tail flick, test, after self-admin0.10.10.20.3-0.30.30.30.3-0.20.2-0.2-0.40.10.2
Delta time to tail flick, vehicle, before/after SA0.30.41.4-1.00.5-1.2-1.0-0.30.2-0.20.20.00.20.3
Delta time to tail flick, test, before/after SA0.10.10.4-0.50.1-0.6-0.60.1-0.20.2-0.2-0.30.10.5
Tibia length0.92.53.11.5-1.61.41.41.6-1.61.6-1.6-1.71.81.6
Ambulatory time before self-admin0.00.10.4-0.40.3-0.3-0.2-0.40.2-0.20.20.6-0.7-0.4
Ambulatory time after self-admin0.00.00.00.0-0.10.20.10.0-0.10.1-0.10.1-0.2-0.1
Bone: tissue strength1.81.92.4-1.11.4-1.2-1.2-1.51.5-1.51.51.5-1.4-1.5
Total heroin consumption1.41.72.11.3-1.41.41.41.3-1.31.3-1.3-1.31.01.1
Bone: trabecular number0.30.71.91.2-0.81.41.40.6-0.40.4-0.4-0.50.40.0
Bone: trabecular spacing0.60.82.8-1.60.8-1.6-1.7-0.40.1-0.10.10.1-0.10.4
Bone: trabecular thickness0.71.02.21.2-0.11.51.5-0.50.7-0.70.70.9-0.7-1.5
Bone: trabecular tissue density1.11.92.8-1.41.5-1.7-1.7-1.41.3-1.31.31.4-1.3-1.0
Water consumed over 24 hours0.51.01.7-0.90.9-0.5-0.5-1.01.1-1.11.11.1-1.3-1.2
Number of responses in last shaping day1.41.82.40.7-1.30.91.01.5-1.51.5-1.5-1.51.41.5