Hub : Genes

Ap1b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ap1b1 0.04 0.03 8.4e-04 0.04 0.04 0.03 0.04 5.6e-05 2.3e-04 1.5e-03 2.6e-04
2 IC gene expression Ap1b1 0.2 0.12 9.0e-08 0.16 0.14 0.14 0.14 2.1e-07 2.4e-06 2.7e-06 2.0e-06
3 PL isoform ratio XM_063273010.1 0.02 0.02 9.1e-03 0.01 0.01 0 0.01 2.2e-02 1.2e-02 9.9e-02 3.8e-02
4 BLA gene expression Ap1b1 0.21 0.11 5.4e-09 0.13 0.14 0.14 0.14 1.5e-07 8.6e-08 1.3e-07 1.2e-07
5 LHb mRNA stability Ap1b1 0.15 0.11 3.4e-03 0.05 0.11 0.04 0.05 2.3e-02 1.5e-03 3.9e-02 2.2e-02
6 IC isoform ratio XM_063273010.1 0.1 0.08 4.1e-04 0.08 0.07 0.06 0.07 4.3e-04 7.7e-04 1.4e-03 8.8e-04
7 NAcc gene expression Ap1b1 0.03 0.02 1.5e-04 0.01 0.02 0.01 0.01 3.2e-03 2.9e-04 1.9e-03 7.9e-03
8 PL gene expression Ap1b1 0.14 0.1 4.4e-11 0.09 0.11 0.1 0.1 8.3e-10 8.5e-12 8.0e-11 1.2e-10
9 Liver gene expression Ap1b1 0.2 0.16 3.2e-10 0.08 0.08 0.09 0.09 3.8e-09 6.4e-09 6.3e-10 5.8e-10
10 Liver alternative polyA XM_063273010.1 0.19 0.12 1.9e-07 0.07 0.06 0.06 0.07 6.0e-08 2.3e-07 8.3e-07 8.4e-08
11 Liver alternative polyA NM_001308298.1 0.13 0.09 4.6e-06 0.06 0.05 0.05 0.05 8.7e-07 1.1e-06 5.6e-06 1.5e-06
12 IL gene expression Ap1b1 0.22 0.14 1.5e-03 0.04 0.09 0.07 0.06 3.9e-02 4.0e-03 1.1e-02 2.0e-02
13 Liver isoform ratio NM_001308298.1 0.3 0.15 4.3e-05 0.03 0.04 0.04 0.03 1.9e-04 9.7e-06 3.0e-05 4.0e-04
14 Adipose gene expression Ap1b1 0.27 0.12 0.0e+00 0.15 0.15 0.15 0.15 3.4e-16 1.2e-16 2.7e-16 4.8e-16
15 Brain intron excision ratio chr14_84142997_84143817 0.04 0.04 7.5e-03 0.02 0.02 0.02 0.02 3.1e-03 3.9e-03 5.2e-03 6.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.20.40.8-0.6-0.6-0.30.70.70.50.80.80.9-0.10.10.9-0.5-0.90.8
Area under the delay curve1.92.94.82.22.22.1-2.0-2.0-1.8-1.8-1.8-1.8-1.61.5-1.4-1.00.2-0.2
BMI with tail0.10.20.70.30.30.2-0.5-0.5-0.1-0.6-0.6-0.50.3-0.2-0.70.40.7-0.8
BMI without tail0.20.81.71.01.11.3-0.8-0.8-0.8-0.6-0.6-0.6-1.31.3-0.2-0.9-0.60.8
Body weight0.94.17.02.52.52.6-2.3-2.3-2.3-2.0-2.0-2.0-2.12.2-1.5-1.4-0.10.2
Weight adjusted by age0.20.61.90.80.71.0-0.5-0.5-0.4-0.3-0.3-0.2-1.41.40.1-1.2-0.90.8
Bone surface0.10.20.90.30.30.4-0.3-0.3-0.3-0.2-0.1-0.0-0.50.5-0.1-0.9-0.40.0
Bone volume0.10.20.90.20.20.4-0.1-0.1-0.2-0.00.10.2-0.50.50.1-1.0-0.60.3
Breakpoint value in progressive ratio session0.30.50.80.90.80.9-0.9-0.9-0.7-0.8-0.8-0.7-0.60.6-0.7-0.50.1-0.3
Number of licking bursts0.82.33.91.81.82.0-1.7-1.7-1.9-1.4-1.3-1.3-1.71.7-1.0-1.4-0.30.3
Context. condit. distance diff. score2.93.55.5-2.3-2.3-2.32.22.22.22.01.91.91.8-1.81.51.3-0.10.3
Locomotion velocity, session 11.41.64.90.30.3-0.3-0.7-0.7-0.4-1.1-1.1-1.21.5-1.5-1.51.82.2-1.8
Locomotion distance, session 10.81.01.6-1.1-1.0-0.81.11.11.01.21.31.30.1-0.11.3-0.4-1.00.9
Locomotion velocity, session 21.01.24.20.10.1-0.5-0.5-0.5-0.1-0.8-0.9-0.91.5-1.5-1.31.31.9-2.1
Locomotion distance, session 21.42.03.7-1.7-1.6-1.91.41.41.71.11.11.11.8-1.80.61.10.5-1.0
Locomotion velocity, session 32.52.84.3-2.1-2.1-1.92.02.02.02.02.02.01.1-1.11.70.2-0.80.5
Locomotion distance, session 30.10.10.9-0.1-0.1-0.10.10.10.20.20.20.3-0.10.10.1-0.9-0.4-0.4
Stereotopy head waving bouts, day 30.81.01.6-1.2-1.2-1.11.21.21.21.21.21.20.6-0.61.0-0.0-0.60.3
Stereotopy head waving duration, day 31.41.72.7-1.6-1.6-1.61.41.41.61.31.21.21.4-1.40.91.20.2-0.0
Locomotion velocity, session 70.10.10.20.40.40.3-0.4-0.4-0.3-0.4-0.4-0.4-0.20.2-0.4-0.30.2-0.5
Locomotion distance, session 70.30.40.9-0.6-0.6-0.80.50.50.60.30.30.21.0-1.00.00.80.6-0.6
Stereotopy head waving bouts, day 70.00.00.1-0.1-0.10.00.10.1-0.00.10.10.2-0.10.10.2-0.0-0.20.3
Stereotopy head waving duration, day 70.10.20.5-0.2-0.20.10.20.2-0.00.40.40.5-0.40.40.5-0.6-0.70.7
Locomotion velocity, session 81.31.63.9-1.3-1.3-1.71.01.01.40.60.60.52.0-2.00.01.41.1-1.5
Locomotion distance, session 85.78.413.6-3.6-3.6-3.73.33.33.42.92.92.83.0-3.02.22.20.1-0.0
Degree of sensitization distance1.31.44.7-1.1-1.1-1.51.01.01.10.60.60.51.8-1.80.22.21.1-0.4
Degree of sensitization stereotypy0.10.10.30.40.40.5-0.4-0.4-0.6-0.3-0.3-0.3-0.50.5-0.2-0.1-0.10.5
Conditioned locomotion1.51.82.9-1.4-1.5-1.11.61.61.51.71.71.70.0-0.01.7-0.3-1.21.3
Cocaine response after cond. corrected1.11.72.81.61.61.7-1.5-1.4-1.5-1.3-1.2-1.3-1.41.4-0.9-0.9-0.10.3
Cocaine response after cond. not corrected1.42.03.61.71.71.9-1.4-1.4-1.6-1.1-1.1-1.0-1.91.9-0.6-1.4-0.70.8
Cocaine response before conditioning0.30.40.7-0.7-0.7-0.50.70.70.80.80.80.80.0-0.00.8-0.3-0.70.4
Saline control response0.50.61.3-0.9-0.9-1.10.80.80.90.60.50.51.1-1.10.20.70.5-0.7
Bone: connectivity density0.30.40.8-0.7-0.7-0.50.80.80.60.80.90.90.1-0.10.8-0.3-0.70.6
Bone: cortical apparent density0.40.61.40.90.91.0-0.9-0.9-1.2-0.8-0.7-0.7-0.80.8-0.5-0.7-0.10.2
Bone: cortical area1.52.54.41.91.92.1-1.7-1.7-1.8-1.4-1.3-1.2-2.02.0-0.9-1.8-0.60.3
Bone: cortical porosity0.10.10.30.10.10.3-0.0-0.0-0.20.00.10.1-0.40.40.2-0.3-0.40.5
Bone: cortical porosity0.20.20.4-0.4-0.4-0.30.50.50.30.50.50.5-0.00.00.60.1-0.40.6
Bone: cortical thickness1.22.15.81.31.31.8-1.1-1.0-1.4-0.6-0.5-0.4-2.32.3-0.0-2.4-1.51.1
Bone: cortical thickness1.31.63.0-1.2-1.2-0.71.41.41.11.61.61.6-0.30.31.7-0.6-1.61.6
Bone: cortical tissue density0.40.71.51.01.01.1-0.9-0.9-1.2-0.8-0.8-0.8-0.80.8-0.6-0.60.00.1
Condit. Reinf. active minus inactive responses1.21.43.20.90.90.4-1.1-1.2-0.8-1.4-1.4-1.50.6-0.6-1.60.81.7-1.8
Condit. Reinf. active-inactive response ratio2.52.78.10.30.3-0.5-0.7-0.8-0.1-1.3-1.4-1.52.0-2.0-1.92.42.8-2.7
Condit. Reinf. active responses0.40.51.40.50.60.2-0.7-0.7-0.5-0.8-0.8-0.90.4-0.4-1.00.31.0-1.2
Condit. Reinf. inactive responses0.50.62.60.00.10.40.10.1-0.20.40.50.6-1.11.10.7-1.6-1.40.9
Incentive salience index mean0.91.12.01.01.10.7-1.2-1.2-0.9-1.3-1.3-1.30.0-0.0-1.4-0.01.0-1.4
Condit. Reinf. lever presses0.10.20.90.30.40.4-0.3-0.3-0.2-0.2-0.2-0.1-0.50.5-0.1-0.9-0.4-0.2
Condit. Reinf. active minus inactive responses0.30.50.8-0.9-0.9-0.90.80.80.90.70.70.50.9-0.90.50.70.10.1
Condit. Reinf. active-inactive response ratio0.00.10.3-0.1-0.2-0.30.10.10.2-0.0-0.0-0.10.5-0.5-0.10.50.4-0.2
Condit. Reinf. active responses0.50.71.4-1.0-1.0-1.10.80.81.00.60.60.51.2-1.20.41.00.4-0.2
Condit. Reinf. inactive responses0.50.71.4-1.0-1.0-1.10.80.80.90.60.50.51.2-1.20.31.20.6-0.4
Condit. Reinf. lever presses0.40.61.1-1.0-1.0-0.90.90.91.00.90.90.90.6-0.60.80.2-0.30.1
Condit. Reinf. lever reinforcers received0.40.61.1-0.9-0.9-1.00.70.70.80.60.60.51.1-1.10.30.80.3-0.2
Conditioned reinforcement - actives0.10.40.70.80.90.7-0.7-0.7-0.5-0.6-0.7-0.6-0.60.6-0.5-0.5-0.0-0.3
Conditioned reinforcement - inactives0.30.81.31.21.11.0-1.1-1.1-1.0-1.1-1.1-1.0-0.60.6-0.9-0.30.4-0.3
Conditioned locomotion0.71.01.81.31.21.3-1.0-1.0-1.1-0.8-0.8-0.8-1.31.3-0.5-1.1-0.40.2
Patch foraging indifference point 0 sec0.72.13.51.81.81.9-1.6-1.6-1.6-1.3-1.3-1.3-1.61.6-0.9-1.2-0.30.2
Patch foraging indifference point AUC0.00.10.20.30.20.2-0.3-0.3-0.3-0.4-0.4-0.30.0-0.0-0.40.00.3-0.5
Delay disc. indifference point, 0s delay0.91.01.91.21.21.4-1.0-1.0-1.0-0.8-0.8-0.7-1.31.3-0.5-1.0-0.50.5
Delay disc. indifference point, 16s delay1.82.64.21.91.91.5-1.9-1.9-1.4-2.0-2.1-2.0-0.60.6-1.9-0.01.2-1.2
Delay disc. indifference point, 2s delay1.41.64.11.21.21.6-0.9-0.8-1.0-0.5-0.4-0.4-2.02.00.1-1.8-1.41.4
Delay disc. indifference point, 24s delay0.71.21.81.31.31.0-1.3-1.3-1.3-1.3-1.3-1.3-0.40.3-1.3-0.20.7-0.8
Delay disc. indifference point, 4s delay2.22.34.31.91.92.1-1.6-1.6-1.7-1.2-1.2-1.1-2.01.9-0.7-1.6-0.70.7
Delay disc. indifference point, 8s delay0.61.01.71.31.31.1-1.2-1.2-1.0-1.2-1.2-1.2-0.70.6-1.0-0.30.4-0.4
Indifference point function ln k0.10.30.9-0.4-0.4-0.10.40.40.10.60.60.7-0.40.40.7-0.8-0.90.8
Indifference point function log k0.10.30.9-0.4-0.4-0.10.40.40.10.60.60.7-0.40.40.7-0.8-0.90.8
Patch foraging total patch changes 0 sec0.72.13.41.81.81.8-1.6-1.6-1.7-1.4-1.4-1.4-1.51.5-1.1-1.1-0.1-0.1
Patch foraging total patch changes 12 sec0.81.11.81.31.31.3-1.1-1.1-1.2-0.9-0.9-0.9-1.31.3-0.7-0.8-0.20.2
Patch foraging total patch changes 18 sec1.12.64.71.81.81.3-1.8-1.9-1.7-2.0-2.0-2.2-0.30.3-2.00.41.5-1.5
Patch foraging total patch changes 24 sec0.30.92.5-0.9-0.9-1.30.80.81.20.60.50.21.3-1.30.21.60.8-0.7
Patch foraging total patch changes 6 sec1.01.72.61.51.51.6-1.5-1.5-1.6-1.4-1.3-1.3-1.21.2-1.1-1.10.1-0.3
Patch foraging time to switch 0 sec0.10.30.5-0.6-0.6-0.60.70.70.70.70.60.50.3-0.30.60.5-0.20.4
Patch foraging water rate 0 sec0.51.92.81.61.61.4-1.7-1.7-1.6-1.6-1.6-1.5-0.80.7-1.5-0.70.7-1.0
Patch foraging water rate 12 sec0.00.00.10.0-0.00.1-0.1-0.10.1-0.1-0.1-0.00.0-0.0-0.1-0.30.0-0.3
Patch foraging water rate 18 sec0.51.13.9-0.3-0.30.20.70.70.51.01.01.1-1.11.11.4-1.0-1.72.0
Patch foraging water rate 24 sec0.30.41.10.30.3-0.0-0.4-0.4-0.2-0.6-0.6-0.70.6-0.6-0.80.81.0-1.0
Patch foraging water rate 6 sec0.20.30.80.60.60.7-0.5-0.5-0.4-0.3-0.3-0.3-0.90.9-0.1-0.9-0.50.3
Seeking ratio, delayed vs. immediate footshock0.00.00.20.20.1-0.0-0.1-0.10.2-0.1-0.2-0.20.2-0.2-0.10.40.3-0.2
Distance traveled before self-admin0.40.82.40.30.40.8-0.1-0.1-0.10.30.30.4-1.41.50.7-1.4-1.41.4
Distance traveled after self-admin0.61.13.3-0.1-0.10.50.40.40.10.70.80.9-1.31.31.2-1.5-1.81.7
Extensor digitorum longus weight2.28.614.83.53.53.8-3.2-3.2-3.5-2.7-2.5-2.4-3.53.5-1.8-3.0-0.80.6
Bone: elastic displacement0.60.71.6-0.8-0.8-0.50.90.90.61.11.11.1-0.20.21.2-0.2-1.01.3
Bone: elastic work0.60.83.00.10.10.60.20.2-0.20.50.60.6-1.31.31.0-1.2-1.51.7
Bone: endosteal estimation0.00.10.20.50.50.4-0.4-0.4-0.4-0.3-0.3-0.3-0.30.3-0.2-0.10.00.1
Bone: endosteal perimeter0.41.01.71.31.31.2-1.2-1.2-1.2-1.1-1.1-1.1-0.80.8-1.0-0.30.4-0.2
Epididymis fat weight0.20.82.70.80.71.1-0.7-0.7-0.9-0.4-0.3-0.3-1.41.4-0.1-1.7-0.90.5
Delta time in closed arm before/after self-admin6.46.09.6-3.0-3.0-2.92.92.83.12.62.52.52.2-2.02.21.9-0.30.6
Delta time in open arm before/after self-admin5.16.19.53.13.12.8-2.9-2.9-2.6-2.7-2.8-2.7-2.02.1-2.4-1.40.7-1.1
Diff in mean of infusions in LGA sessions0.00.10.1-0.2-0.2-0.20.30.30.30.30.30.20.10.00.30.2-0.10.3
Delay discount exponential model param2.02.74.6-2.1-2.1-2.01.91.91.81.71.81.71.5-1.41.41.0-0.10.1
Extinction: sum of active levers before priming0.20.31.30.30.20.0-0.4-0.4-0.3-0.5-0.6-0.60.3-0.3-0.70.20.7-1.2
Active lever presses in extinction session 60.20.20.5-0.1-0.10.00.30.30.50.40.40.4-0.40.50.6-0.4-0.70.5
Bone: final force0.10.20.40.50.50.6-0.5-0.5-0.5-0.4-0.4-0.4-0.60.6-0.2-0.6-0.20.0
Bone: final moment0.20.40.70.70.70.8-0.6-0.6-0.7-0.4-0.4-0.4-0.90.9-0.2-0.8-0.40.3
Food consumed during 24 hour testing period1.22.44.21.61.61.2-1.8-1.9-1.6-2.0-1.9-1.8-0.10.1-2.0-0.21.4-1.7
Glucose21.534.159.05.95.94.2-6.7-6.7-5.8-7.3-7.4-7.40.1-0.1-7.71.56.2-6.2
Heart weight0.60.92.70.30.3-0.2-0.6-0.6-0.5-0.9-0.9-1.01.0-1.1-1.21.01.6-1.6
Delay discount hyperbolic model param2.12.64.5-2.1-2.1-2.11.91.91.81.61.61.61.7-1.61.21.20.1-0.1
Intermittent access intake day 1-15 change0.21.22.11.01.00.8-1.2-1.3-1.2-1.3-1.3-1.3-0.20.2-1.4-0.21.0-1.4
Intermittent access intake escalation0.20.91.60.90.80.7-1.1-1.1-1.1-1.2-1.1-1.1-0.10.1-1.2-0.20.9-1.3
Intermittent access intake escalation 20.10.20.30.50.30.3-0.5-0.5-0.6-0.5-0.5-0.6-0.10.0-0.50.00.4-0.4
Intermitt. access day 1 inactive lever presses0.00.21.0-0.5-0.4-0.50.20.20.40.10.10.20.8-0.9-0.11.00.6-0.1
Intermitt. access day 15 inactive lever presses0.52.54.41.51.41.1-1.8-1.8-1.8-2.0-1.9-2.0-0.20.1-2.10.31.7-1.7
Intermitt. access escalation Index0.20.72.70.10.0-0.3-0.4-0.4-0.4-0.7-0.7-0.90.9-0.9-1.11.01.5-1.6
Intermittent access day 1 total infusions0.20.51.50.90.80.9-0.4-0.4-0.3-0.1-0.2-0.2-1.21.20.2-0.9-0.90.8
Intermittent access day 15 total infusions0.82.03.51.91.71.7-1.6-1.6-1.5-1.4-1.5-1.5-1.41.5-1.2-1.20.0-0.5
Intermittent access terminal intake (last 3 days)0.81.32.61.61.51.4-1.2-1.2-1.0-1.1-1.2-1.2-1.41.4-0.8-1.0-0.2-0.2
Intermittent access total infusions1.11.32.31.51.41.4-1.1-1.1-1.0-0.9-1.0-1.0-1.41.5-0.6-1.1-0.40.1
Intermittent access day 1 locomotion0.20.31.00.1-0.00.10.30.30.30.50.50.4-0.60.60.7-0.5-0.91.0
Intermittent access day 15 total locomotion0.31.32.31.41.51.4-1.3-1.3-1.1-1.2-1.3-1.2-1.01.1-1.0-0.60.1-0.3
Intermittent access total locomotion0.91.12.11.41.31.3-1.1-1.1-1.0-1.0-1.0-1.1-1.21.2-0.7-0.9-0.2-0.1
Intermittent access standard deviation0.10.61.0-0.6-0.8-0.60.90.90.81.01.01.00.2-0.21.0-0.1-0.80.8
Left kidney weight0.10.73.40.40.30.8-0.0-0.0-0.60.20.30.4-1.21.20.7-0.7-1.11.8
Right kidney weight0.32.49.7-0.2-0.20.50.80.80.11.31.41.4-1.71.71.9-1.6-2.53.1
Cocaine induced anxiety0.82.33.81.81.71.7-1.8-1.8-1.9-1.6-1.6-1.5-1.31.2-1.4-1.30.2-0.7
Post-drug Anxiety1.51.73.21.51.51.3-1.5-1.5-1.8-1.5-1.4-1.5-0.90.8-1.4-0.90.5-0.8
Baseline Anxiety0.10.20.4-0.3-0.3-0.50.20.20.20.00.0-0.10.6-0.6-0.20.60.6-0.6
Tail length1.36.813.33.03.03.5-2.5-2.4-3.1-1.9-1.7-1.7-3.63.5-0.8-2.8-1.51.9
Length with tail1.66.913.03.13.13.5-2.6-2.6-3.1-2.0-1.8-1.9-3.63.6-1.0-2.8-1.31.6
Length without tail0.10.40.80.70.70.9-0.7-0.7-0.7-0.6-0.6-0.5-0.80.8-0.4-0.8-0.20.1
Times rat made contact with spout1.31.55.10.30.3-0.3-0.7-0.7-0.3-1.1-1.1-1.11.5-1.5-1.61.32.1-2.2
Lifetime Intake1.01.22.51.51.41.4-1.0-1.0-0.8-0.7-0.8-0.8-1.61.6-0.4-1.3-0.70.4
Liver weight, left0.71.22.8-0.8-0.8-0.41.11.10.71.31.41.4-0.40.41.5-0.7-1.51.7
Liver weight, right1.01.72.9-1.4-1.4-1.01.51.51.61.61.61.70.3-0.21.6-0.2-1.21.2
Locomotor activity1.11.72.91.41.41.1-1.5-1.5-1.1-1.6-1.7-1.6-0.10.1-1.60.61.3-1.0
Locomotor testing distance0.30.71.90.80.81.1-0.5-0.5-0.7-0.3-0.2-0.1-1.41.40.2-1.1-0.91.1
Locomotor testing rearing0.62.23.31.71.81.8-1.7-1.7-1.8-1.5-1.5-1.5-1.41.4-1.2-1.20.0-0.2
Locomotion in novel chamber2.43.35.1-2.0-2.2-1.82.22.22.32.22.22.20.7-0.72.10.2-1.21.1
Locomotion in novel chamber post-restriction0.92.86.3-1.9-1.8-2.21.41.41.71.00.90.82.5-2.50.32.31.4-1.2
Fecal boli incidents, locomotor time 10.00.10.4-0.4-0.3-0.40.20.20.10.10.10.20.5-0.7-0.10.40.4-0.4
Change in fecal boli incidents, locomotor task0.70.71.80.50.40.0-0.6-0.6-0.5-0.9-0.8-1.00.8-0.8-1.10.81.3-1.3
Time >=10cm from walls, locomotor time 10.00.00.20.0-0.0-0.0-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.30.30.4-0.3
Bouts of movement, locomotor time 10.81.12.00.80.90.5-1.0-1.1-0.8-1.2-1.3-1.40.4-0.3-1.40.71.4-1.4
Total resting periods, locomotor time 10.91.02.70.40.5-0.0-0.7-0.7-0.4-1.0-1.1-1.20.9-0.8-1.31.11.6-1.6
Rest time, locomotor task time 10.20.30.80.10.1-0.1-0.3-0.3-0.3-0.5-0.5-0.50.7-0.6-0.70.40.8-0.9
Distance moved, locomotor task time 10.20.51.40.60.50.8-0.3-0.3-0.5-0.0-0.00.1-1.21.20.3-0.9-0.91.1
Vertical activity count, locomotor time 10.00.20.60.50.40.6-0.3-0.3-0.2-0.1-0.1-0.0-0.80.70.1-0.4-0.50.7
Time >=10cm from walls, locomotor time 20.00.10.40.00.0-0.1-0.1-0.10.3-0.2-0.3-0.20.4-0.4-0.30.70.5-0.6
Bouts of movement, locomotor time 20.00.00.00.10.1-0.10.10.10.10.10.1-0.1-0.1-0.10.10.1-0.00.0
Total resting periods, locomotor time 20.00.00.10.20.2-0.1-0.0-0.00.0-0.1-0.1-0.30.1-0.2-0.10.10.2-0.3
Rest time, locomotor task time 20.10.10.4-0.4-0.4-0.50.30.20.10.10.20.10.6-0.6-0.10.30.4-0.5
Distance moved, locomotor task time 20.00.00.0-0.1-0.1-0.00.10.10.10.10.10.20.1-0.10.10.2-0.00.2
Vertical activity count, locomotor time 20.00.00.20.10.10.2-0.1-0.10.10.0-0.00.1-0.20.20.1-0.0-0.20.4
Light reinforcement 10.10.62.50.30.30.5-0.0-0.0-0.30.30.30.3-1.21.20.5-1.6-1.30.7
Light reinforcement 20.30.72.10.60.60.7-0.1-0.1-0.20.20.10.1-1.51.40.5-1.1-1.21.2
Bone: marrow area0.00.10.10.40.40.3-0.3-0.3-0.2-0.2-0.3-0.3-0.20.2-0.20.00.00.1
Bone: maximum diameter3.16.39.33.03.02.7-3.0-3.0-3.0-3.0-3.0-2.9-1.41.4-2.7-0.91.2-1.3
Bone: maximum force0.20.31.10.40.40.6-0.3-0.3-0.4-0.1-0.1-0.0-0.90.90.2-1.0-0.80.5
Bone: maximum moment0.30.51.60.50.50.8-0.4-0.4-0.5-0.1-0.1-0.0-1.21.20.2-1.3-1.00.8
Mean time between licks in bursts0.31.73.61.01.00.5-1.3-1.3-1.0-1.6-1.6-1.60.7-0.7-1.81.11.9-1.7
Mean num. licks in bursts0.92.36.2-1.4-1.4-1.91.01.01.40.50.40.32.5-2.5-0.22.11.7-1.8
Cd content in liver0.60.71.10.80.80.6-0.9-0.9-0.8-1.0-1.0-1.0-0.00.0-1.10.20.8-0.8
Co content in liver0.30.31.20.20.20.6-0.2-0.2-0.60.00.10.2-0.90.90.2-1.1-0.80.6
Cu content in liver0.20.20.40.40.40.3-0.6-0.6-0.6-0.6-0.6-0.60.00.0-0.60.00.5-0.5
Fe content in liver1.62.04.1-1.6-1.6-1.91.41.41.51.11.01.12.0-2.00.61.70.7-0.6
K content in liver2.12.17.51.01.01.6-0.7-0.7-1.1-0.2-0.10.1-2.42.30.4-2.7-1.91.2
Mg content in liver0.40.42.10.40.40.6-0.3-0.3-0.5-0.1-0.10.0-1.11.00.1-1.5-0.80.3
Mn content in liver0.70.83.30.10.10.50.10.2-0.10.50.50.6-1.31.30.7-1.8-1.50.8
Na content in liver1.92.23.11.81.81.6-1.8-1.8-1.7-1.7-1.7-1.7-0.90.9-1.6-0.80.6-1.0
Rb content in liver1.61.94.11.51.51.7-1.3-1.3-1.4-1.0-0.9-0.9-2.02.0-0.5-1.8-0.80.5
Se content in liver1.11.35.80.70.71.2-0.5-0.5-0.6-0.1-0.10.1-1.91.90.3-2.4-1.70.7
Sr content in liver3.53.04.42.02.01.8-2.1-2.1-2.0-2.1-2.1-2.1-0.90.9-1.9-0.51.0-1.0
Zn content in liver0.30.41.50.30.30.6-0.3-0.2-0.6-0.00.00.1-1.01.00.2-1.2-0.80.6
Bone: minimum diameter0.10.10.3-0.1-0.1-0.00.20.20.30.30.30.4-0.30.30.4-0.4-0.60.4
Time in familiar zone, hab. session 10.20.20.3-0.4-0.4-0.40.50.50.60.50.50.50.1-0.10.5-0.0-0.30.2
Time in novel zone, hab. session 10.40.40.90.70.70.9-0.6-0.6-0.7-0.4-0.4-0.3-0.90.9-0.2-0.8-0.40.5
Total zone transitions, hab. session 10.00.00.20.00.0-0.0-0.1-0.1-0.2-0.2-0.1-0.10.2-0.2-0.3-0.10.2-0.5
Total locomotion distance, hab. session 10.10.20.90.30.30.4-0.2-0.2-0.2-0.1-0.1-0.0-0.60.60.0-0.9-0.50.0
Locomotion velocity, hab. session 10.00.00.30.10.1-0.0-0.1-0.10.0-0.2-0.2-0.10.1-0.1-0.2-0.20.2-0.5
Time in familiar zone, hab. session 21.11.32.8-1.2-1.2-1.41.21.21.41.00.90.81.3-1.30.81.70.40.2
Time in novel zone, hab. session 21.61.73.81.41.41.6-1.4-1.4-1.6-1.2-1.1-0.9-1.51.5-0.9-2.0-0.5-0.1
Total zone transitions, hab. session 20.40.50.70.80.80.8-0.9-0.8-0.9-0.8-0.7-0.7-0.60.6-0.7-0.90.1-0.4
Total locomotion distance, hab. session 20.50.71.00.90.90.8-1.0-1.0-0.9-1.0-1.0-1.0-0.40.4-1.0-0.70.4-0.9
Locomotion velocity, hab. session 20.70.91.31.11.11.0-1.1-1.1-1.1-1.1-1.1-1.1-0.60.6-1.0-0.80.3-0.8
Novel to familiar place preference ratio1.11.42.41.21.20.9-1.4-1.4-1.3-1.5-1.5-1.5-0.00.0-1.60.31.2-1.1
Novelty place preference1.21.52.61.21.21.0-1.4-1.4-1.3-1.6-1.6-1.5-0.00.0-1.60.31.2-1.2
Time in novel zone, NPP test1.11.42.41.21.20.9-1.4-1.4-1.3-1.5-1.5-1.5-0.10.1-1.50.21.2-1.1
Total zone transitions, NPP test0.60.91.5-1.0-1.0-0.81.11.11.01.21.21.2-0.00.01.2-0.6-1.10.7
Total locomotion distance, NPP test0.20.30.4-0.5-0.5-0.40.60.60.50.60.70.6-0.00.00.6-0.5-0.60.4
Locomotion velocity, NPP test0.10.10.2-0.2-0.2-0.10.30.30.30.40.40.4-0.20.20.4-0.4-0.50.3
Intraocular pressure0.50.91.80.70.70.3-0.9-0.9-0.9-1.1-1.1-1.10.6-0.5-1.30.61.3-1.3
Delta distance traveled before/after self-admin0.50.50.8-0.9-0.9-0.90.90.90.80.80.80.80.7-0.80.60.6-0.10.2
Delta ambulatory time before/after self-admin0.40.71.2-1.1-1.1-1.01.01.00.80.90.91.00.8-0.90.70.5-0.10.2
Parametrial fat weight3.89.016.62.62.71.6-3.2-3.2-2.5-3.7-3.8-3.90.7-0.7-4.11.73.8-3.7
Pavlov. Cond. lever latency0.40.60.90.90.90.7-0.9-0.9-0.8-0.9-1.0-1.0-0.20.2-0.90.30.7-0.4
Pavlov. Cond. magazine entry latency2.02.64.5-2.0-2.0-2.01.91.92.11.71.71.71.4-1.41.40.8-0.30.0
Pavlov. Cond. change in total contacts0.50.50.70.80.80.8-0.8-0.8-0.8-0.8-0.7-0.7-0.50.5-0.7-0.80.1-0.6
Pavlov. Cond. index score2.12.74.3-2.0-2.0-1.92.02.02.11.91.91.91.1-1.11.60.2-0.80.3
Pavlov. Cond. latency score1.72.23.4-1.8-1.8-1.61.81.81.81.71.71.70.9-0.91.50.2-0.80.4
Pavlov. Cond. lever contacts1.11.32.1-1.4-1.4-1.11.31.31.31.41.41.40.5-0.51.3-0.3-0.90.4
Pavlov. Cond. magazine entry number2.33.05.22.22.22.1-2.0-2.0-2.3-1.8-1.8-1.8-1.61.6-1.4-0.60.30.3
Pavlov. Cond. intertrial magazine entries0.70.82.40.80.81.1-0.5-0.4-0.7-0.2-0.1-0.1-1.61.60.3-1.1-1.01.1
Pavlov. Cond. lever-magazine prob. diff.2.63.25.1-2.2-2.2-2.02.22.22.32.12.12.11.1-1.11.80.2-0.90.4
Pavlov. Cond. response bias1.51.83.0-1.7-1.6-1.41.61.61.71.61.61.70.7-0.71.4-0.4-1.00.2
Pavlov. Cond. lever latency2.73.88.82.22.22.6-1.7-1.7-2.0-1.2-1.1-0.9-3.03.0-0.4-2.5-1.51.4
Pavlov. Cond. magazine entry latency0.10.10.2-0.5-0.5-0.40.40.40.30.40.50.40.3-0.30.3-0.2-0.20.1
Pavlov. Cond. change in total contacts0.10.30.8-0.4-0.5-0.60.30.20.40.10.1-0.00.9-0.9-0.20.80.7-0.6
Pavlov. Cond. index score0.81.22.6-1.3-1.3-1.51.01.01.20.80.80.61.6-1.60.41.20.6-0.7
Pavlov. Cond. latency score0.91.52.6-1.5-1.5-1.61.31.31.41.01.00.91.6-1.60.61.00.4-0.4
Pavlov. Cond. lever contacts2.73.98.3-2.3-2.3-2.61.81.82.21.41.31.12.9-2.90.62.51.3-1.2
Pavlov. Cond. magazine entry number0.10.10.50.30.30.4-0.1-0.1-0.10.0-0.00.0-0.70.70.2-0.4-0.50.6
Pavlov. Cond. intertrial magazine entries0.00.00.00.10.10.0-0.1-0.1-0.0-0.1-0.1-0.00.0-0.0-0.10.20.2-0.1
Pavlov. Cond. lever-magazine prob. diff.0.91.32.4-1.4-1.4-1.51.21.21.30.90.90.81.6-1.60.51.10.5-0.5
Pavlov. Cond. response bias1.42.04.9-1.5-1.5-1.81.11.11.30.80.70.62.2-2.20.21.91.2-1.1
Time in closed arm before self-admin0.20.41.00.50.40.8-0.3-0.2-0.4-0.00.00.3-1.00.90.3-1.0-1.01.0
Time in closed arm after self-admin2.22.53.9-1.9-1.9-1.61.81.91.81.81.82.01.0-0.91.70.7-0.81.1
Time in open arm before self-admin0.40.50.9-0.9-0.9-0.90.90.90.90.80.80.70.6-0.70.60.4-0.20.1
Time in open arm after self-admin1.41.52.81.31.30.8-1.4-1.4-0.8-1.5-1.6-1.7-0.10.1-1.60.21.2-1.6
Bone: periosteal estimation0.51.22.11.31.31.4-1.2-1.2-1.2-1.0-0.9-0.9-1.31.3-0.6-1.0-0.30.3
Bone: periosteal perimeter1.01.93.11.71.71.8-1.6-1.6-1.7-1.4-1.4-1.4-1.41.4-1.1-0.90.1-0.0
Bone: post-yield work0.00.00.20.20.20.2-0.2-0.2-0.2-0.2-0.1-0.1-0.30.3-0.1-0.4-0.1-0.0
Progressive ratio test 1 active lever presses0.40.71.21.11.01.0-0.8-0.8-0.7-0.6-0.7-0.7-1.11.1-0.4-0.9-0.40.1
Progressive ratio test 1 breakpoint0.40.61.11.11.01.0-0.8-0.8-0.7-0.6-0.7-0.7-1.01.0-0.4-0.8-0.30.0
Progressive ratio test 1 inactive lever presses1.64.26.32.52.42.5-2.4-2.4-2.4-2.2-2.2-2.0-1.81.8-1.8-1.50.3-0.6
Progressive ratio test 2 active lever presses0.60.91.61.21.31.2-1.1-1.1-0.9-1.0-1.0-1.0-0.91.0-0.8-0.8-0.0-0.3
Progressive ratio test 2 breakpoint0.60.81.31.11.21.0-1.0-1.0-0.8-0.9-1.0-1.0-0.80.8-0.8-0.60.1-0.5
Progressive ratio test 2 inactive lever presses0.61.93.01.61.61.3-1.6-1.6-1.3-1.6-1.7-1.6-0.70.7-1.6-0.30.8-1.2
Incentive Sensitization - Responses0.10.40.70.60.80.5-0.7-0.7-0.5-0.8-0.8-0.8-0.10.2-0.80.10.5-0.6
Incentive Sensitization - Breakpoint0.10.30.60.50.70.4-0.6-0.6-0.4-0.7-0.7-0.7-0.00.1-0.70.20.5-0.6
Sum of active levers in priming session hrs 5-60.10.10.70.10.00.4-0.2-0.2-0.6-0.1-0.00.1-0.30.5-0.0-0.8-0.40.1
Progressive ratio0.00.10.3-0.1-0.3-0.10.40.40.40.50.40.5-0.10.10.5-0.1-0.60.6
Food seeking constrained by brief footshock2.43.07.21.71.72.3-1.3-1.3-1.8-0.8-0.7-0.7-2.72.7-0.0-2.3-1.61.9
Seeking ratio, punishment vs. effort0.30.61.30.70.81.0-0.7-0.7-1.1-0.5-0.4-0.5-1.11.1-0.2-1.1-0.50.6
Retroperitoneal fat weight0.83.66.71.61.60.9-1.9-2.0-1.6-2.3-2.3-2.50.6-0.6-2.61.22.5-2.4
Reaction time number correct0.00.21.00.00.0-0.1-0.2-0.2-0.0-0.4-0.4-0.30.4-0.4-0.50.10.6-1.0
Reaction time mean minus median0.31.74.7-1.2-1.2-1.60.80.81.00.40.40.32.2-2.2-0.12.11.5-1.0
Reaction time mean minus median AUC0.11.02.1-1.2-1.1-1.30.90.91.00.70.70.71.4-1.40.41.20.6-0.3
Reaction time num false alarms0.40.62.60.00.10.40.20.20.00.50.60.6-1.01.00.8-1.6-1.51.0
Reaction time num false alarms AUC0.51.13.6-0.1-0.10.30.50.50.20.90.91.0-1.21.21.2-1.8-1.91.5
Reaction time trials correct on left0.00.21.00.00.0-0.1-0.2-0.2-0.0-0.4-0.4-0.30.4-0.4-0.50.10.6-1.0
Reaction time trials on left0.00.20.9-0.0-0.0-0.2-0.2-0.20.0-0.3-0.3-0.30.4-0.4-0.50.10.6-1.0
Reaction time mean0.30.82.4-0.9-0.9-1.10.70.70.70.50.40.51.3-1.30.21.50.8-0.2
Reaction time mean AUC0.41.02.2-1.1-1.1-1.31.01.00.90.80.80.81.4-1.40.51.50.50.1
Median of all reaction times0.30.41.5-0.6-0.6-0.70.50.50.40.40.40.40.9-0.90.21.20.50.1
Reaction time omissions1.01.62.5-1.6-1.6-1.61.41.41.31.31.31.31.3-1.31.01.0-0.00.2
Reaction time false alarm rate1.01.34.1-0.1-0.10.40.50.50.10.91.01.1-1.31.31.3-1.7-2.01.9
Reaction time premature initiation rate2.43.75.9-2.3-2.3-1.82.32.32.02.32.42.40.8-0.82.20.1-1.41.3
Reaction time premature initiations0.72.13.3-1.8-1.8-1.51.71.71.61.71.71.80.8-0.81.5-0.0-0.90.5
Std. dev. reaction times0.51.64.7-1.2-1.1-1.50.80.81.00.50.40.32.1-2.1-0.02.21.4-0.8
Reaction time trials completed0.00.20.9-0.0-0.0-0.2-0.2-0.20.0-0.3-0.3-0.30.4-0.4-0.50.10.6-1.0
Reaction time trials AUC0.00.10.80.10.10.0-0.3-0.3-0.1-0.4-0.4-0.30.3-0.3-0.5-0.00.5-0.9
Run reversals in cocaine runway, females0.70.81.4-1.1-1.0-1.10.90.91.00.70.70.61.2-1.20.41.20.4-0.1
Run reversals in cocaine runway, males0.30.40.70.70.70.8-0.6-0.6-0.8-0.5-0.4-0.4-0.70.7-0.2-0.6-0.30.5
Latency to leave start box in cocaine runway0.20.20.70.10.00.40.10.1-0.10.20.30.3-0.80.80.5-0.7-0.90.8
Latency to leave start box in cocaine runway, F0.81.02.50.80.71.2-0.5-0.5-0.9-0.2-0.1-0.1-1.61.60.3-1.5-1.21.3
Latency to leave start box in cocaine runway, M0.40.30.8-0.7-0.7-0.70.60.60.90.50.30.40.6-0.60.30.80.2-0.4
Std. dev. time between licks in bursts0.10.10.3-0.1-0.1-0.2-0.0-0.00.1-0.1-0.1-0.10.5-0.5-0.30.50.5-0.5
Total sessions with >9 infusions0.91.12.5-0.6-0.7-0.41.01.01.01.31.21.4-0.50.51.5-0.9-1.61.3
Short access day 1 total inactive lever presses1.83.66.62.32.32.6-2.0-2.0-2.0-1.7-1.7-1.4-2.42.4-1.1-2.0-0.70.5
Short access day 10 total inactive lever presses0.00.00.20.20.20.3-0.2-0.2-0.2-0.2-0.2-0.0-0.10.1-0.10.10.00.4
Short access day 1 total infusions0.51.02.6-0.5-0.6-0.30.91.00.81.21.21.3-0.60.51.4-1.0-1.61.3
Short access day 10 total infusions0.20.41.30.0-0.00.10.40.40.60.60.50.6-0.60.60.8-0.7-1.10.8
Short access total infusions0.50.72.20.60.50.7-0.0-0.00.10.30.20.3-1.41.40.7-1.4-1.51.1
Short access day 1 locomotion1.42.35.3-0.9-1.0-0.51.41.51.01.81.81.9-0.80.72.1-1.6-2.31.9
Short access day 10 total locomotion0.31.42.7-0.8-0.8-0.51.21.21.11.41.41.5-0.40.41.6-0.7-1.61.5
Short access total locomotion1.31.93.7-1.0-1.1-0.71.51.51.31.71.71.8-0.40.41.9-0.9-1.91.7
One hour access (0.3 mA shock)1.21.42.51.61.61.5-1.3-1.3-1.1-1.1-1.2-1.1-1.31.3-0.9-1.1-0.2-0.3
Compulsive drug intake1.01.42.6-1.5-1.4-1.41.41.41.61.31.21.21.1-1.11.11.1-0.20.4
One hour access (shock baseline)0.71.83.21.81.71.6-1.5-1.5-1.2-1.4-1.5-1.5-1.41.4-1.2-1.00.0-0.6
Social response proportion1.72.24.11.31.30.9-1.6-1.6-1.5-1.9-1.8-1.70.5-0.5-2.00.71.9-1.7
Social responses2.12.74.91.61.61.1-1.9-1.9-1.8-2.1-2.1-2.00.2-0.2-2.20.31.8-1.9
Social time0.30.51.70.20.2-0.1-0.5-0.5-0.4-0.7-0.7-0.70.8-0.8-0.91.01.3-0.9
Soleus weight0.82.36.11.61.52.0-1.1-1.1-1.4-0.6-0.6-0.6-2.52.50.1-1.7-1.41.7
Bone: stiffness0.00.00.1-0.2-0.2-0.20.20.20.30.10.10.10.2-0.20.10.10.0-0.0
Tibialis anterior weight0.82.74.52.12.12.1-1.9-1.9-1.9-1.8-1.7-1.8-1.51.6-1.4-1.00.20.0
Time to tail flick, vehicle, before self-admin0.00.10.20.00.00.10.10.10.10.20.20.1-0.20.30.3-0.3-0.40.5
Time to tail flick, vehicle, after self-admin0.10.20.3-0.5-0.5-0.60.60.60.50.50.60.40.5-0.40.50.5-0.00.3
Time to tail flick, test, before self-admin0.20.20.6-0.00.00.20.20.20.20.30.30.4-0.50.50.5-0.5-0.70.7
Time to tail flick, test, after self-admin2.02.14.41.61.71.9-1.4-1.4-1.7-1.2-1.1-1.2-1.92.1-0.7-1.7-0.60.5
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.2-0.2-0.40.20.20.40.10.10.00.5-0.50.00.70.4-0.2
Delta time to tail flick, test, before/after SA0.81.01.91.01.00.9-1.1-1.1-1.2-1.2-1.2-1.4-0.30.5-1.2-0.20.7-0.9
Tibia length0.51.45.3-0.4-0.40.10.90.90.61.21.21.1-1.31.31.6-0.8-1.82.3
Ambulatory time before self-admin0.51.44.30.80.81.3-0.5-0.4-0.6-0.0-0.00.1-2.02.10.5-2.0-1.71.5
Ambulatory time after self-admin0.40.72.1-0.0-0.00.50.30.30.10.60.60.7-1.11.20.9-1.2-1.51.4
Bone: tissue strength0.10.10.20.30.30.2-0.3-0.3-0.3-0.4-0.4-0.40.1-0.1-0.40.30.4-0.1
Total heroin consumption0.00.00.0-0.0-0.1-0.10.20.20.20.20.20.10.00.10.2-0.1-0.20.1
Bone: trabecular number0.20.41.3-0.3-0.30.00.50.50.20.60.70.7-0.60.60.9-0.7-1.11.1
Bone: trabecular spacing0.91.32.01.41.41.2-1.4-1.4-1.4-1.4-1.4-1.3-0.60.6-1.3-0.30.7-0.7
Bone: trabecular thickness1.41.93.0-1.5-1.5-1.21.61.61.51.71.71.70.3-0.31.70.0-1.11.3
Bone: trabecular tissue density0.50.82.4-0.4-0.4-0.80.10.10.4-0.2-0.2-0.41.5-1.5-0.61.61.5-1.2
Water consumed over 24 hours0.81.62.91.21.20.9-1.5-1.5-1.3-1.6-1.6-1.60.2-0.2-1.7-0.01.3-1.6
Number of responses in last shaping day0.20.20.4-0.6-0.5-0.50.50.50.40.50.40.70.3-0.40.3-0.2-0.2-0.4