Hub : Genes

Ap1b1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Ap1b1 0.04 0.03 8.4e-04 0.04 0.04 0.03 0.04 5.6e-05 2.3e-04 1.2e-03 2.6e-04
2 IC gene expression Ap1b1 0.2 0.12 9.0e-08 0.16 0.14 0.14 0.14 2.1e-07 2.4e-06 2.7e-06 2.0e-06
3 BLA gene expression Ap1b1 0.21 0.11 5.4e-09 0.13 0.14 0.14 0.14 1.5e-07 8.6e-08 1.3e-07 1.2e-07
4 LHb mRNA stability Ap1b1 0.15 0.11 3.4e-03 0.05 0.11 0.04 0.05 2.3e-02 1.5e-03 4.0e-02 2.2e-02
5 IC isoform ratio XM_063273010.1 0.1 0.08 4.1e-04 0.08 0.07 0.06 0.07 4.3e-04 7.7e-04 1.4e-03 9.5e-04
6 NAcc gene expression Ap1b1 0.03 0.02 1.5e-04 0.01 0.02 0.01 0.01 3.2e-03 2.9e-04 1.9e-03 8.0e-03
7 PL gene expression Ap1b1 0.14 0.1 4.4e-11 0.09 0.11 0.1 0.1 8.3e-10 8.5e-12 8.0e-11 1.3e-10
8 Liver gene expression Ap1b1 0.2 0.16 3.2e-10 0.08 0.08 0.09 0.09 3.8e-09 6.4e-09 8.1e-10 5.3e-10
9 Liver alternative polyA XM_063273010.1 0.19 0.12 1.9e-07 0.07 0.06 0.06 0.07 6.0e-08 2.3e-07 8.5e-07 8.3e-08
10 Liver alternative polyA NM_001308298.1 0.13 0.09 4.6e-06 0.06 0.05 0.05 0.05 8.7e-07 1.1e-06 5.6e-06 1.6e-06
11 IL gene expression Ap1b1 0.22 0.14 1.5e-03 0.04 0.09 0.07 0.05 3.9e-02 4.0e-03 1.1e-02 2.0e-02
12 Liver isoform ratio NM_001308298.1 0.3 0.15 4.3e-05 0.03 0.04 0.04 0.03 1.9e-04 9.7e-06 3.0e-05 3.3e-04
13 Adipose gene expression Ap1b1 0.27 0.12 0.0e+00 0.15 0.15 0.15 0.15 3.4e-16 1.2e-16 2.7e-16 5.1e-16
14 Brain intron excision ratio chr14_84142997_84143817 0.04 0.04 7.5e-03 0.02 0.02 0.02 0.02 3.1e-03 3.9e-03 5.2e-03 7.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.30.50.80.60.60.70.7-0.50.80.80.90.1-0.10.9-0.5-0.9-0.8
Area under the delay curve2.42.74.8-2.2-2.2-2.0-2.01.8-1.8-1.8-1.81.6-1.5-1.4-1.00.20.2
BMI with tail0.10.20.7-0.3-0.3-0.5-0.50.1-0.6-0.6-0.5-0.30.2-0.70.40.70.8
BMI without tail0.30.81.7-1.0-1.1-0.8-0.80.8-0.6-0.6-0.61.3-1.3-0.2-0.9-0.6-0.8
Body weight0.93.86.4-2.5-2.5-2.3-2.32.3-2.0-2.0-2.02.1-2.2-1.5-1.4-0.1-0.2
Weight adjusted by age0.40.61.9-0.8-0.7-0.5-0.50.4-0.3-0.3-0.21.4-1.40.1-1.2-0.9-0.8
Bone surface0.10.20.9-0.3-0.3-0.3-0.30.3-0.2-0.1-0.00.5-0.5-0.1-0.9-0.4-0.0
Bone volume0.10.20.9-0.2-0.2-0.1-0.10.2-0.00.10.20.5-0.50.1-1.0-0.6-0.3
Breakpoint value in progressive ratio session0.40.50.8-0.9-0.8-0.9-0.90.7-0.8-0.8-0.70.6-0.6-0.7-0.50.10.3
Number of licking bursts1.32.23.5-1.8-1.8-1.7-1.71.9-1.4-1.3-1.31.7-1.7-1.0-1.4-0.3-0.3
Context. condit. distance diff. score2.83.35.52.32.32.22.2-2.22.01.91.9-1.81.81.51.3-0.1-0.3
Locomotion velocity, session 11.61.74.9-0.3-0.3-0.7-0.70.4-1.1-1.1-1.2-1.51.5-1.51.82.21.8
Locomotion distance, session 10.81.01.61.11.01.11.1-1.01.21.31.3-0.10.11.3-0.4-1.0-0.9
Locomotion velocity, session 21.11.34.2-0.1-0.1-0.5-0.50.1-0.8-0.9-0.9-1.51.5-1.31.31.92.1
Locomotion distance, session 21.31.83.41.71.61.41.4-1.71.11.11.1-1.81.80.61.10.51.0
Locomotion velocity, session 32.42.84.32.12.12.02.0-2.02.02.02.0-1.11.11.70.2-0.8-0.5
Locomotion distance, session 30.10.10.90.10.10.10.1-0.20.20.20.30.1-0.10.1-0.9-0.40.4
Stereotopy head waving bouts, day 30.81.01.61.21.21.21.2-1.21.21.21.2-0.60.61.0-0.0-0.6-0.3
Stereotopy head waving duration, day 31.31.62.61.61.61.41.4-1.61.31.21.2-1.41.40.91.20.20.0
Locomotion velocity, session 70.10.10.2-0.4-0.4-0.4-0.40.3-0.4-0.4-0.40.2-0.2-0.4-0.30.20.5
Locomotion distance, session 70.30.30.90.60.60.50.5-0.60.30.30.2-1.01.00.00.80.60.6
Stereotopy head waving bouts, day 70.00.00.10.10.10.10.10.00.10.10.20.1-0.10.2-0.0-0.2-0.3
Stereotopy head waving duration, day 70.20.20.50.20.20.20.20.00.40.40.50.4-0.40.5-0.6-0.7-0.7
Locomotion velocity, session 81.31.53.91.31.31.01.0-1.40.60.60.5-2.02.00.01.41.11.5
Locomotion distance, session 85.58.012.93.63.63.33.3-3.42.92.92.8-3.03.02.22.20.10.0
Degree of sensitization distance1.31.44.71.11.11.01.0-1.10.60.60.5-1.81.80.22.21.10.4
Degree of sensitization stereotypy0.10.10.3-0.4-0.4-0.4-0.40.6-0.3-0.3-0.30.5-0.5-0.2-0.1-0.1-0.5
Conditioned locomotion1.61.82.91.41.51.61.6-1.51.71.71.7-0.00.01.7-0.3-1.2-1.3
Cocaine response after cond. corrected1.31.62.6-1.6-1.6-1.5-1.41.5-1.3-1.2-1.31.4-1.4-0.9-0.9-0.1-0.3
Cocaine response after cond. not corrected1.61.93.6-1.7-1.7-1.4-1.41.6-1.1-1.1-1.01.9-1.9-0.6-1.4-0.7-0.8
Cocaine response before conditioning0.40.40.70.70.70.70.7-0.80.80.80.8-0.00.00.8-0.3-0.7-0.4
Saline control response0.40.61.10.90.90.80.8-0.90.60.50.5-1.11.10.20.70.50.7
Bone: connectivity density0.30.50.80.70.70.80.8-0.60.80.90.9-0.10.10.8-0.3-0.7-0.6
Bone: cortical apparent density0.40.61.4-0.9-0.9-0.9-0.91.2-0.8-0.7-0.70.8-0.8-0.5-0.7-0.1-0.2
Bone: cortical area1.52.44.0-1.9-1.9-1.7-1.71.8-1.4-1.3-1.22.0-2.0-0.9-1.8-0.6-0.3
Bone: cortical porosity0.10.10.3-0.1-0.1-0.0-0.00.20.00.10.10.4-0.40.2-0.3-0.4-0.5
Bone: cortical porosity0.20.20.40.40.40.50.5-0.30.50.50.50.0-0.00.60.1-0.4-0.6
Bone: cortical thickness1.22.05.8-1.3-1.3-1.1-1.01.4-0.6-0.5-0.42.3-2.3-0.0-2.4-1.5-1.1
Bone: cortical thickness1.41.73.01.21.21.41.4-1.11.61.61.60.3-0.31.7-0.6-1.6-1.6
Bone: cortical tissue density0.50.71.5-1.0-1.0-0.9-0.91.2-0.8-0.8-0.80.8-0.8-0.6-0.60.0-0.1
Condit. Reinf. active minus inactive responses1.31.53.2-0.9-0.9-1.1-1.20.8-1.4-1.4-1.5-0.60.6-1.60.81.71.8
Condit. Reinf. active-inactive response ratio2.72.98.1-0.3-0.3-0.7-0.80.1-1.3-1.4-1.5-2.02.0-1.92.42.82.7
Condit. Reinf. active responses0.40.61.4-0.5-0.6-0.7-0.70.5-0.8-0.8-0.9-0.40.4-1.00.31.01.2
Condit. Reinf. inactive responses0.50.62.6-0.0-0.10.10.10.20.40.50.61.1-1.10.7-1.6-1.4-0.9
Incentive salience index mean0.91.12.0-1.0-1.1-1.2-1.20.9-1.3-1.3-1.3-0.00.0-1.4-0.01.01.4
Condit. Reinf. lever presses0.10.20.9-0.3-0.4-0.3-0.30.2-0.2-0.2-0.10.5-0.5-0.1-0.9-0.40.2
Condit. Reinf. active minus inactive responses0.40.50.80.90.90.80.8-0.90.70.70.5-0.90.90.50.70.1-0.1
Condit. Reinf. active-inactive response ratio0.10.10.30.10.20.10.1-0.2-0.0-0.0-0.1-0.50.5-0.10.50.40.2
Condit. Reinf. active responses0.50.71.41.01.00.80.8-1.00.60.60.5-1.21.20.41.00.40.2
Condit. Reinf. inactive responses0.50.71.41.01.00.80.8-0.90.60.50.5-1.21.20.31.20.60.4
Condit. Reinf. lever presses0.50.61.11.01.00.90.9-1.00.90.90.9-0.60.60.80.2-0.3-0.1
Condit. Reinf. lever reinforcers received0.40.51.10.90.90.70.7-0.80.60.60.5-1.11.10.30.80.30.2
Conditioned reinforcement - actives0.20.40.7-0.8-0.9-0.7-0.70.5-0.6-0.7-0.60.6-0.6-0.5-0.5-0.00.3
Conditioned reinforcement - inactives0.50.81.3-1.2-1.1-1.1-1.11.0-1.1-1.1-1.00.6-0.6-0.9-0.30.40.3
Conditioned locomotion0.71.01.8-1.3-1.2-1.0-1.01.1-0.8-0.8-0.81.3-1.3-0.5-1.1-0.4-0.2
Patch foraging indifference point 0 sec1.12.03.4-1.8-1.8-1.6-1.61.6-1.3-1.3-1.31.6-1.6-0.9-1.2-0.3-0.2
Patch foraging indifference point AUC0.10.10.2-0.3-0.2-0.3-0.30.3-0.4-0.4-0.3-0.00.0-0.40.00.30.5
Delay disc. indifference point, 0s delay0.80.91.7-1.2-1.2-1.0-1.01.0-0.8-0.8-0.71.3-1.3-0.5-1.0-0.5-0.5
Delay disc. indifference point, 16s delay2.42.64.2-1.9-1.9-1.9-1.91.4-2.0-2.1-2.00.6-0.6-1.9-0.01.21.2
Delay disc. indifference point, 2s delay1.41.54.1-1.2-1.2-0.9-0.81.0-0.5-0.4-0.42.0-2.00.1-1.8-1.4-1.4
Delay disc. indifference point, 24s delay1.11.21.8-1.3-1.3-1.3-1.31.3-1.3-1.3-1.30.4-0.3-1.3-0.20.70.8
Delay disc. indifference point, 4s delay2.12.24.1-1.9-1.9-1.6-1.61.7-1.2-1.2-1.12.0-1.9-0.7-1.6-0.7-0.7
Delay disc. indifference point, 8s delay0.81.01.7-1.3-1.3-1.2-1.21.0-1.2-1.2-1.20.7-0.6-1.0-0.30.40.4
Indifference point function ln k0.20.30.90.40.40.40.4-0.10.60.60.70.4-0.40.7-0.8-0.9-0.8
Indifference point function log k0.20.30.90.40.40.40.4-0.10.60.60.70.4-0.40.7-0.8-0.9-0.8
Patch foraging total patch changes 0 sec1.02.03.4-1.8-1.8-1.6-1.61.7-1.4-1.4-1.41.5-1.5-1.1-1.1-0.10.1
Patch foraging total patch changes 12 sec0.81.01.7-1.3-1.3-1.1-1.11.2-0.9-0.9-0.91.3-1.3-0.7-0.8-0.2-0.2
Patch foraging total patch changes 18 sec1.72.74.7-1.8-1.8-1.8-1.91.7-2.0-2.0-2.20.3-0.3-2.00.41.51.5
Patch foraging total patch changes 24 sec0.50.92.50.90.90.80.8-1.20.60.50.2-1.31.30.21.60.80.7
Patch foraging total patch changes 6 sec1.11.62.6-1.5-1.5-1.5-1.51.6-1.4-1.3-1.31.2-1.2-1.1-1.10.10.3
Patch foraging time to switch 0 sec0.10.30.50.60.60.70.7-0.70.70.60.5-0.30.30.60.5-0.2-0.4
Patch foraging water rate 0 sec0.91.92.8-1.6-1.6-1.7-1.71.6-1.6-1.6-1.50.8-0.7-1.5-0.70.71.0
Patch foraging water rate 12 sec0.00.00.1-0.00.0-0.1-0.1-0.1-0.1-0.1-0.0-0.00.0-0.1-0.30.00.3
Patch foraging water rate 18 sec0.81.23.90.30.30.70.7-0.51.01.01.11.1-1.11.4-1.0-1.7-2.0
Patch foraging water rate 24 sec0.30.41.1-0.3-0.3-0.4-0.40.2-0.6-0.6-0.7-0.60.6-0.80.81.01.0
Patch foraging water rate 6 sec0.20.30.8-0.6-0.6-0.5-0.50.4-0.3-0.3-0.30.9-0.9-0.1-0.9-0.5-0.3
Seeking ratio, delayed vs. immediate footshock0.00.00.2-0.2-0.1-0.1-0.1-0.2-0.1-0.2-0.2-0.20.2-0.10.40.30.2
Distance traveled before self-admin0.60.82.4-0.3-0.4-0.1-0.10.10.30.30.41.4-1.50.7-1.4-1.4-1.4
Distance traveled after self-admin0.91.13.30.10.10.40.4-0.10.70.80.91.3-1.31.2-1.5-1.8-1.7
Extensor digitorum longus weight2.18.212.6-3.5-3.5-3.2-3.23.5-2.7-2.5-2.43.5-3.5-1.8-3.0-0.8-0.6
Bone: elastic displacement0.70.81.60.80.80.90.9-0.61.11.11.10.2-0.21.2-0.2-1.0-1.3
Bone: elastic work0.70.93.0-0.1-0.10.20.20.20.50.60.61.3-1.31.0-1.2-1.5-1.7
Bone: endosteal estimation0.00.10.2-0.5-0.5-0.4-0.40.4-0.3-0.3-0.30.3-0.3-0.2-0.10.0-0.1
Bone: endosteal perimeter0.51.01.7-1.3-1.3-1.2-1.21.2-1.1-1.1-1.10.8-0.8-1.0-0.30.40.2
Epididymis fat weight0.20.82.7-0.8-0.7-0.7-0.70.9-0.4-0.3-0.31.4-1.4-0.1-1.7-0.9-0.5
Delta time in closed arm before/after self-admin6.25.89.63.03.02.92.8-3.12.62.52.5-2.22.02.21.9-0.3-0.6
Delta time in open arm before/after self-admin6.05.99.5-3.1-3.1-2.9-2.92.6-2.7-2.8-2.72.0-2.1-2.4-1.40.71.1
Diff in mean of infusions in LGA sessions0.00.10.10.20.20.30.3-0.30.30.30.2-0.1-0.00.30.2-0.1-0.3
Delay discount exponential model param2.32.64.62.12.11.91.9-1.81.71.81.7-1.51.41.41.0-0.1-0.1
Extinction: sum of active levers before priming0.30.31.3-0.3-0.2-0.4-0.40.3-0.5-0.6-0.6-0.30.3-0.70.20.71.2
Active lever presses in extinction session 60.20.20.50.10.10.30.3-0.50.40.40.40.4-0.50.6-0.4-0.7-0.5
Bone: final force0.10.20.4-0.5-0.5-0.5-0.50.5-0.4-0.4-0.40.6-0.6-0.2-0.6-0.2-0.0
Bone: final moment0.20.40.7-0.7-0.7-0.6-0.60.7-0.4-0.4-0.40.9-0.9-0.2-0.8-0.4-0.3
Food consumed during 24 hour testing period1.82.54.2-1.6-1.6-1.8-1.91.6-2.0-1.9-1.80.1-0.1-2.0-0.21.41.7
Glucose22.435.359.0-5.9-5.9-6.7-6.75.8-7.3-7.4-7.4-0.10.1-7.71.56.26.2
Heart weight0.61.02.7-0.3-0.3-0.6-0.60.5-0.9-0.9-1.0-1.01.1-1.21.01.61.6
Delay discount hyperbolic model param2.32.54.52.12.11.91.9-1.81.61.61.6-1.71.61.21.20.10.1
Intermittent access intake day 1-15 change0.61.22.1-1.0-1.0-1.2-1.31.2-1.3-1.3-1.30.2-0.2-1.4-0.21.01.4
Intermittent access intake escalation0.40.91.6-0.9-0.8-1.1-1.11.1-1.2-1.1-1.10.1-0.1-1.2-0.20.91.3
Intermittent access intake escalation 20.20.20.3-0.5-0.3-0.5-0.50.6-0.5-0.5-0.60.1-0.0-0.50.00.40.4
Intermitt. access day 1 inactive lever presses0.10.21.00.50.40.20.2-0.40.10.10.2-0.80.9-0.11.00.60.1
Intermitt. access day 15 inactive lever presses1.32.64.4-1.5-1.4-1.8-1.81.8-2.0-1.9-2.00.2-0.1-2.10.31.71.7
Intermitt. access escalation Index0.60.82.7-0.1-0.0-0.4-0.40.4-0.7-0.7-0.9-0.90.9-1.11.01.51.6
Intermittent access day 1 total infusions0.30.51.5-0.9-0.8-0.4-0.40.3-0.1-0.2-0.21.2-1.20.2-0.9-0.9-0.8
Intermittent access day 15 total infusions1.32.03.5-1.9-1.7-1.6-1.61.5-1.4-1.5-1.51.4-1.5-1.2-1.20.00.5
Intermittent access terminal intake (last 3 days)1.01.32.6-1.6-1.5-1.2-1.21.0-1.1-1.2-1.21.4-1.4-0.8-1.0-0.20.2
Intermittent access total infusions1.01.22.3-1.5-1.4-1.1-1.11.0-0.9-1.0-1.01.4-1.5-0.6-1.1-0.4-0.1
Intermittent access day 1 locomotion0.20.31.0-0.10.00.30.3-0.30.50.50.40.6-0.60.7-0.5-0.9-1.0
Intermittent access day 15 total locomotion0.71.22.3-1.4-1.5-1.3-1.31.1-1.2-1.3-1.21.0-1.1-1.0-0.60.10.3
Intermittent access total locomotion0.91.02.1-1.4-1.3-1.1-1.11.0-1.0-1.0-1.11.2-1.2-0.7-0.9-0.20.1
Intermittent access standard deviation0.30.61.00.60.80.90.9-0.81.01.01.0-0.20.21.0-0.1-0.8-0.8
Left kidney weight0.10.73.4-0.4-0.3-0.0-0.00.60.20.30.41.2-1.20.7-0.7-1.1-1.8
Right kidney weight0.62.59.70.20.20.80.8-0.11.31.41.41.7-1.71.9-1.6-2.5-3.1
Cocaine induced anxiety1.62.23.8-1.8-1.7-1.8-1.81.9-1.6-1.6-1.51.3-1.2-1.4-1.30.20.7
Post-drug Anxiety1.61.73.2-1.5-1.5-1.5-1.51.8-1.5-1.4-1.50.9-0.8-1.4-0.90.50.8
Baseline Anxiety0.10.20.40.30.30.20.2-0.20.00.0-0.1-0.60.6-0.20.60.60.6
Tail length1.66.413.3-3.0-3.0-2.5-2.43.1-1.9-1.7-1.73.6-3.5-0.8-2.8-1.5-1.9
Length with tail1.56.513.0-3.1-3.1-2.6-2.63.1-2.0-1.8-1.83.6-3.6-1.0-2.8-1.3-1.6
Length without tail0.10.40.7-0.7-0.7-0.7-0.70.7-0.6-0.6-0.50.8-0.8-0.4-0.8-0.2-0.1
Times rat made contact with spout1.41.65.1-0.3-0.3-0.7-0.70.3-1.1-1.1-1.2-1.51.5-1.61.32.12.2
Lifetime Intake1.01.22.5-1.5-1.4-1.0-1.00.8-0.7-0.8-0.81.6-1.6-0.4-1.3-0.7-0.4
Liver weight, left0.81.32.80.80.81.11.1-0.71.31.41.40.4-0.41.5-0.7-1.5-1.7
Liver weight, right1.01.82.91.41.41.51.5-1.61.61.61.7-0.30.21.6-0.2-1.2-1.2
Locomotor activity1.11.72.9-1.4-1.4-1.5-1.51.1-1.6-1.7-1.60.1-0.1-1.60.61.31.0
Locomotor testing distance0.40.71.9-0.8-0.8-0.5-0.50.7-0.3-0.2-0.11.4-1.40.2-1.1-0.9-1.1
Locomotor testing rearing1.02.13.2-1.7-1.8-1.7-1.71.8-1.5-1.5-1.51.4-1.4-1.2-1.20.00.2
Locomotion in novel chamber2.63.35.12.02.22.22.2-2.32.22.22.2-0.70.72.10.2-1.2-1.1
Locomotion in novel chamber post-restriction1.62.76.31.91.81.41.4-1.71.00.90.8-2.52.50.32.31.41.2
Fecal boli incidents, locomotor time 10.10.10.40.40.30.20.2-0.10.10.10.2-0.50.7-0.10.40.40.4
Change in fecal boli incidents, locomotor task0.80.71.8-0.5-0.4-0.6-0.60.5-0.9-0.8-1.0-0.80.8-1.10.81.31.3
Time >=10cm from walls, locomotor time 10.10.10.2-0.00.0-0.2-0.20.2-0.2-0.2-0.2-0.20.2-0.30.30.40.3
Bouts of movement, locomotor time 11.01.22.0-0.8-0.9-1.0-1.10.8-1.2-1.3-1.4-0.40.3-1.40.71.41.4
Total resting periods, locomotor time 11.01.12.7-0.4-0.5-0.7-0.70.4-1.0-1.1-1.2-0.90.8-1.31.11.61.6
Rest time, locomotor task time 10.20.30.8-0.1-0.1-0.3-0.30.3-0.5-0.5-0.5-0.70.6-0.70.40.80.9
Distance moved, locomotor task time 10.30.51.4-0.6-0.5-0.3-0.30.5-0.0-0.00.11.2-1.20.3-0.9-0.9-1.1
Vertical activity count, locomotor time 10.10.20.6-0.5-0.4-0.3-0.30.2-0.1-0.1-0.00.8-0.70.1-0.4-0.5-0.7
Time >=10cm from walls, locomotor time 20.10.10.4-0.0-0.0-0.1-0.1-0.3-0.2-0.3-0.2-0.40.4-0.30.70.50.6
Bouts of movement, locomotor time 20.00.00.0-0.1-0.10.10.1-0.10.10.1-0.10.10.10.10.1-0.0-0.0
Total resting periods, locomotor time 20.00.00.1-0.2-0.2-0.0-0.0-0.0-0.1-0.1-0.3-0.10.2-0.10.10.20.3
Rest time, locomotor task time 20.10.10.40.40.40.30.2-0.10.10.20.1-0.60.6-0.10.30.40.5
Distance moved, locomotor task time 20.00.00.00.10.10.10.1-0.10.10.10.2-0.10.10.10.2-0.0-0.2
Vertical activity count, locomotor time 20.00.00.2-0.1-0.1-0.1-0.1-0.10.0-0.00.10.2-0.20.1-0.0-0.2-0.4
Light reinforcement 10.20.62.5-0.3-0.3-0.0-0.00.30.30.30.31.2-1.20.5-1.6-1.3-0.7
Light reinforcement 20.40.72.1-0.6-0.6-0.1-0.10.20.20.10.11.5-1.40.5-1.1-1.2-1.2
Bone: marrow area0.00.10.1-0.4-0.4-0.3-0.30.2-0.2-0.3-0.30.2-0.2-0.20.00.0-0.1
Bone: maximum diameter3.36.29.3-3.0-3.0-3.0-3.03.0-3.0-3.0-2.91.4-1.4-2.7-0.91.21.3
Bone: maximum force0.20.31.1-0.4-0.4-0.3-0.30.4-0.1-0.1-0.00.9-0.90.2-1.0-0.8-0.5
Bone: maximum moment0.30.51.6-0.5-0.5-0.4-0.40.5-0.1-0.1-0.01.2-1.20.2-1.3-1.0-0.8
Mean time between licks in bursts0.81.83.6-1.0-1.0-1.3-1.31.0-1.6-1.6-1.6-0.70.7-1.81.11.91.7
Mean num. licks in bursts1.42.26.21.41.41.01.0-1.40.50.40.3-2.52.5-0.22.11.71.8
Cd content in liver0.60.71.1-0.8-0.8-0.9-0.90.8-1.0-1.0-1.00.0-0.0-1.10.20.80.8
Co content in liver0.30.31.2-0.2-0.2-0.2-0.20.60.00.10.20.9-0.90.2-1.1-0.8-0.6
Cu content in liver0.20.20.4-0.4-0.4-0.6-0.60.6-0.6-0.6-0.6-0.0-0.0-0.60.00.50.5
Fe content in liver1.61.94.11.61.61.41.4-1.51.11.01.0-2.02.00.61.70.70.6
K content in liver2.12.07.5-1.0-1.0-0.7-0.71.1-0.2-0.10.12.4-2.30.4-2.7-1.9-1.2
Mg content in liver0.40.42.1-0.4-0.4-0.3-0.30.5-0.1-0.10.01.1-1.00.1-1.5-0.8-0.3
Mn content in liver0.70.83.3-0.1-0.10.10.20.10.50.50.61.3-1.30.7-1.8-1.5-0.8
Na content in liver2.02.23.1-1.8-1.8-1.8-1.81.7-1.7-1.7-1.70.9-0.9-1.6-0.80.61.0
Rb content in liver1.51.84.1-1.5-1.5-1.3-1.31.4-1.0-0.9-0.92.0-2.0-0.5-1.8-0.8-0.5
Se content in liver1.11.35.8-0.7-0.7-0.5-0.50.6-0.1-0.10.11.9-1.90.3-2.4-1.7-0.7
Sr content in liver3.43.04.4-2.0-2.0-2.1-2.12.0-2.1-2.1-2.00.9-0.9-1.9-0.51.01.0
Zn content in liver0.30.41.5-0.3-0.3-0.3-0.20.6-0.00.00.11.0-1.00.2-1.2-0.8-0.6
Bone: minimum diameter0.10.10.30.10.10.20.2-0.30.30.30.40.3-0.30.4-0.4-0.6-0.4
Time in familiar zone, hab. session 10.20.20.30.40.40.50.5-0.60.50.50.5-0.10.10.5-0.0-0.3-0.2
Time in novel zone, hab. session 10.40.40.9-0.7-0.7-0.6-0.60.7-0.4-0.4-0.30.9-0.9-0.2-0.8-0.4-0.5
Total zone transitions, hab. session 10.00.00.2-0.0-0.0-0.1-0.10.2-0.2-0.1-0.1-0.20.2-0.3-0.10.20.5
Total locomotion distance, hab. session 10.10.20.9-0.3-0.3-0.2-0.20.2-0.1-0.1-0.00.6-0.60.0-0.9-0.5-0.0
Locomotion velocity, hab. session 10.00.00.3-0.1-0.1-0.1-0.1-0.0-0.2-0.2-0.1-0.10.1-0.2-0.20.20.5
Time in familiar zone, hab. session 21.21.22.81.21.21.21.2-1.41.00.90.8-1.31.30.81.70.4-0.2
Time in novel zone, hab. session 21.71.73.8-1.4-1.4-1.4-1.41.6-1.2-1.1-0.91.5-1.5-0.9-2.0-0.50.1
Total zone transitions, hab. session 20.40.50.7-0.8-0.8-0.9-0.80.9-0.8-0.7-0.70.6-0.6-0.7-0.90.10.4
Total locomotion distance, hab. session 20.50.71.0-0.9-0.9-1.0-1.00.9-1.0-1.0-1.00.4-0.4-1.0-0.70.40.9
Locomotion velocity, hab. session 20.70.91.3-1.1-1.1-1.1-1.11.1-1.1-1.1-1.10.6-0.6-1.0-0.80.30.8
Novel to familiar place preference ratio1.31.52.4-1.2-1.2-1.4-1.41.3-1.5-1.5-1.50.0-0.0-1.60.31.21.1
Novelty place preference1.41.52.6-1.2-1.2-1.4-1.41.3-1.6-1.6-1.50.0-0.0-1.60.31.21.2
Time in novel zone, NPP test1.31.42.4-1.2-1.2-1.4-1.41.3-1.5-1.5-1.50.1-0.1-1.50.21.21.1
Total zone transitions, NPP test0.71.01.51.01.01.11.1-1.01.21.21.20.0-0.01.2-0.6-1.1-0.7
Total locomotion distance, NPP test0.20.30.40.50.50.60.6-0.50.60.70.60.0-0.00.6-0.5-0.6-0.4
Locomotion velocity, NPP test0.10.10.20.20.20.30.3-0.30.40.40.40.2-0.20.4-0.4-0.5-0.3
Intraocular pressure0.70.91.8-0.7-0.7-0.9-0.90.9-1.1-1.1-1.1-0.60.5-1.30.61.31.3
Delta distance traveled before/after self-admin0.50.50.80.90.90.90.9-0.80.80.80.8-0.70.80.60.6-0.1-0.2
Delta ambulatory time before/after self-admin0.60.71.21.11.11.01.0-0.80.90.91.0-0.80.90.70.5-0.1-0.2
Parametrial fat weight4.09.416.6-2.6-2.7-3.2-3.22.5-3.7-3.8-3.9-0.70.7-4.11.73.83.7
Pavlov. Cond. lever latency0.50.60.9-0.9-0.9-0.9-0.90.8-0.9-1.0-1.00.2-0.2-0.90.30.70.4
Pavlov. Cond. magazine entry latency1.92.54.52.02.01.91.9-2.11.71.71.7-1.41.41.40.8-0.3-0.0
Pavlov. Cond. change in total contacts0.50.50.7-0.8-0.8-0.8-0.80.8-0.8-0.7-0.70.5-0.5-0.7-0.80.10.6
Pavlov. Cond. index score2.12.64.32.02.02.02.0-2.11.91.91.9-1.11.11.60.2-0.8-0.3
Pavlov. Cond. latency score1.72.13.41.81.81.81.8-1.81.71.71.7-0.90.91.50.2-0.8-0.4
Pavlov. Cond. lever contacts1.11.32.11.41.41.31.3-1.31.41.41.4-0.50.51.3-0.3-0.9-0.4
Pavlov. Cond. magazine entry number2.32.85.2-2.2-2.2-2.0-2.02.3-1.8-1.8-1.81.6-1.6-1.4-0.60.3-0.3
Pavlov. Cond. intertrial magazine entries0.60.82.4-0.8-0.8-0.5-0.40.7-0.2-0.1-0.11.6-1.60.3-1.1-1.0-1.1
Pavlov. Cond. lever-magazine prob. diff.2.63.25.12.22.22.22.2-2.32.12.12.1-1.11.11.80.2-0.9-0.4
Pavlov. Cond. response bias1.51.83.01.71.61.61.6-1.71.61.61.7-0.70.71.4-0.4-1.0-0.2
Pavlov. Cond. lever latency2.73.68.8-2.2-2.2-1.7-1.72.0-1.2-1.1-0.93.0-3.0-0.4-2.5-1.5-1.4
Pavlov. Cond. magazine entry latency0.10.10.20.50.50.40.4-0.30.40.50.4-0.30.30.3-0.2-0.2-0.1
Pavlov. Cond. change in total contacts0.20.30.80.40.50.30.2-0.40.10.1-0.0-0.90.9-0.20.80.70.6
Pavlov. Cond. index score0.81.12.61.31.31.01.0-1.20.80.80.6-1.61.60.41.20.60.7
Pavlov. Cond. latency score1.01.42.51.51.51.31.3-1.41.01.00.9-1.61.60.61.00.40.4
Pavlov. Cond. lever contacts2.73.78.32.32.31.81.8-2.21.41.31.1-2.92.90.62.51.31.2
Pavlov. Cond. magazine entry number0.10.10.5-0.3-0.3-0.1-0.10.10.0-0.00.00.7-0.70.2-0.4-0.5-0.6
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.1-0.1-0.10.0-0.1-0.1-0.1-0.00.0-0.10.20.20.1
Pavlov. Cond. lever-magazine prob. diff.0.91.22.41.41.41.21.2-1.30.90.90.8-1.61.60.51.10.50.5
Pavlov. Cond. response bias1.41.94.91.51.51.11.1-1.30.80.70.6-2.22.20.21.91.21.1
Time in closed arm before self-admin0.30.41.0-0.5-0.4-0.3-0.20.4-0.00.00.31.0-0.90.3-1.0-1.0-1.0
Time in closed arm after self-admin2.42.53.91.91.91.81.9-1.81.81.82.0-1.00.91.70.7-0.8-1.1
Time in open arm before self-admin0.50.50.80.90.90.90.9-0.90.80.80.7-0.60.70.60.4-0.2-0.1
Time in open arm after self-admin1.41.62.8-1.3-1.3-1.4-1.40.8-1.5-1.6-1.70.1-0.1-1.60.21.21.6
Bone: periosteal estimation0.51.11.8-1.3-1.3-1.2-1.21.2-1.0-0.9-0.91.3-1.3-0.6-1.0-0.3-0.3
Bone: periosteal perimeter1.11.93.0-1.7-1.7-1.6-1.61.7-1.4-1.4-1.41.4-1.4-1.1-0.90.10.0
Bone: post-yield work0.00.00.2-0.2-0.2-0.2-0.20.2-0.2-0.1-0.10.3-0.3-0.1-0.4-0.10.0
Progressive ratio test 1 active lever presses0.50.61.2-1.1-1.0-0.8-0.80.7-0.6-0.7-0.71.1-1.1-0.4-0.9-0.4-0.1
Progressive ratio test 1 breakpoint0.50.61.1-1.1-1.0-0.8-0.80.7-0.6-0.7-0.71.0-1.0-0.4-0.8-0.3-0.0
Progressive ratio test 1 inactive lever presses2.84.06.3-2.5-2.4-2.4-2.42.4-2.2-2.2-2.01.8-1.8-1.8-1.50.30.6
Progressive ratio test 2 active lever presses0.70.91.6-1.2-1.3-1.1-1.10.9-1.0-1.0-1.00.9-1.0-0.8-0.8-0.00.3
Progressive ratio test 2 breakpoint0.60.71.3-1.1-1.2-1.0-1.00.8-0.9-1.0-1.00.8-0.8-0.8-0.60.10.5
Progressive ratio test 2 inactive lever presses1.11.93.0-1.6-1.6-1.6-1.61.3-1.6-1.7-1.60.7-0.7-1.6-0.30.81.2
Incentive Sensitization - Responses0.30.40.7-0.6-0.8-0.7-0.70.5-0.8-0.8-0.80.1-0.2-0.80.10.50.6
Incentive Sensitization - Breakpoint0.20.30.6-0.5-0.7-0.6-0.60.4-0.7-0.7-0.70.0-0.1-0.70.20.50.6
Sum of active levers in priming session hrs 5-60.10.10.7-0.1-0.0-0.2-0.20.6-0.1-0.00.10.3-0.5-0.0-0.8-0.4-0.1
Progressive ratio0.10.20.30.10.30.40.4-0.40.50.40.50.1-0.10.5-0.1-0.6-0.6
Food seeking constrained by brief footshock2.32.97.2-1.7-1.7-1.3-1.31.8-0.8-0.7-0.72.7-2.7-0.0-2.3-1.6-1.9
Seeking ratio, punishment vs. effort0.40.61.3-0.7-0.8-0.7-0.71.1-0.5-0.4-0.51.1-1.1-0.2-1.1-0.5-0.6
Retroperitoneal fat weight0.93.86.7-1.6-1.6-1.9-2.01.6-2.3-2.3-2.5-0.60.6-2.61.22.52.4
Reaction time number correct0.10.21.0-0.0-0.0-0.2-0.20.0-0.4-0.4-0.3-0.40.4-0.50.10.61.0
Reaction time mean minus median0.71.64.71.21.20.80.8-1.00.40.40.3-2.22.2-0.12.11.51.0
Reaction time mean minus median AUC0.40.92.11.21.10.90.9-1.00.70.70.7-1.41.40.41.20.60.3
Reaction time num false alarms0.50.72.6-0.0-0.10.20.2-0.00.50.60.61.0-1.00.8-1.6-1.5-1.0
Reaction time num false alarms AUC0.81.23.60.10.10.50.5-0.20.90.91.01.2-1.21.2-1.8-1.9-1.5
Reaction time trials correct on left0.10.21.0-0.0-0.0-0.2-0.20.0-0.4-0.4-0.3-0.40.4-0.50.10.61.0
Reaction time trials on left0.10.20.90.00.0-0.2-0.2-0.0-0.3-0.3-0.3-0.40.4-0.50.10.61.0
Reaction time mean0.50.72.40.90.90.70.7-0.70.50.40.5-1.31.30.21.50.80.2
Reaction time mean AUC0.61.02.21.11.11.01.0-0.90.80.80.8-1.41.40.51.50.5-0.1
Median of all reaction times0.30.41.50.60.60.50.5-0.40.40.40.4-0.90.90.21.20.5-0.1
Reaction time omissions1.01.52.51.61.61.41.4-1.31.31.31.3-1.31.31.01.0-0.0-0.2
Reaction time false alarm rate1.01.44.10.10.10.50.5-0.10.91.01.11.3-1.31.3-1.7-2.0-1.9
Reaction time premature initiation rate2.73.75.92.32.32.32.3-2.02.32.42.4-0.80.82.20.1-1.4-1.3
Reaction time premature initiations1.12.03.31.81.81.71.7-1.61.71.71.8-0.80.81.5-0.0-0.9-0.5
Std. dev. reaction times0.81.54.71.21.10.80.8-1.00.50.40.3-2.12.1-0.02.21.40.8
Reaction time trials completed0.10.20.90.00.0-0.2-0.2-0.0-0.3-0.3-0.3-0.40.4-0.50.10.61.0
Reaction time trials AUC0.10.10.8-0.1-0.1-0.3-0.30.1-0.4-0.4-0.3-0.30.3-0.5-0.00.50.9
Run reversals in cocaine runway, females0.80.81.41.11.00.90.9-1.00.70.70.6-1.21.20.41.20.40.1
Run reversals in cocaine runway, males0.30.30.7-0.7-0.7-0.6-0.60.8-0.5-0.4-0.40.7-0.7-0.2-0.6-0.3-0.5
Latency to leave start box in cocaine runway0.20.30.7-0.1-0.00.10.10.10.20.30.30.8-0.80.5-0.7-0.9-0.8
Latency to leave start box in cocaine runway, F0.80.92.5-0.8-0.7-0.5-0.50.9-0.2-0.1-0.11.6-1.60.3-1.5-1.2-1.3
Latency to leave start box in cocaine runway, M0.30.30.80.70.70.60.6-0.90.50.30.4-0.60.60.30.80.20.4
Std. dev. time between licks in bursts0.10.10.30.10.1-0.0-0.0-0.1-0.1-0.1-0.1-0.50.5-0.30.50.50.5
Total sessions with >9 infusions0.91.22.50.60.71.01.0-1.01.31.21.40.5-0.51.5-0.9-1.6-1.3
Short access day 1 total inactive lever presses2.63.45.8-2.3-2.3-2.0-2.02.0-1.7-1.7-1.42.4-2.4-1.1-2.0-0.7-0.5
Short access day 10 total inactive lever presses0.00.00.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.00.1-0.1-0.10.10.0-0.4
Short access day 1 total infusions0.81.12.60.50.60.91.0-0.81.21.21.30.6-0.51.4-1.0-1.6-1.3
Short access day 10 total infusions0.30.41.3-0.00.00.40.4-0.60.60.50.60.6-0.60.8-0.7-1.1-0.8
Short access total infusions0.60.82.2-0.6-0.5-0.0-0.0-0.10.30.20.31.4-1.40.7-1.4-1.5-1.1
Short access day 1 locomotion2.02.45.30.91.01.41.5-1.01.81.81.90.8-0.72.1-1.6-2.3-1.9
Short access day 10 total locomotion0.81.42.70.80.81.21.2-1.11.41.41.50.4-0.41.6-0.7-1.6-1.5
Short access total locomotion1.72.03.71.01.11.51.5-1.31.71.71.80.4-0.41.9-0.9-1.9-1.7
One hour access (0.3 mA shock)1.21.42.5-1.6-1.6-1.3-1.31.1-1.1-1.2-1.11.3-1.3-0.9-1.1-0.20.3
Compulsive drug intake1.21.42.61.51.41.41.4-1.61.31.21.2-1.11.11.11.1-0.2-0.4
One hour access (shock baseline)1.21.83.2-1.8-1.7-1.5-1.51.2-1.4-1.5-1.51.4-1.4-1.2-1.00.00.6
Social response proportion2.02.34.1-1.3-1.3-1.6-1.61.5-1.9-1.8-1.7-0.50.5-2.00.71.91.7
Social responses2.22.84.9-1.6-1.6-1.9-1.91.8-2.1-2.1-2.0-0.20.2-2.20.31.81.9
Social time0.40.61.7-0.2-0.2-0.5-0.50.4-0.7-0.7-0.7-0.80.8-0.91.01.30.9
Soleus weight0.72.26.1-1.6-1.5-1.1-1.11.4-0.6-0.6-0.62.5-2.50.1-1.7-1.4-1.7
Bone: stiffness0.00.00.10.20.20.20.2-0.30.10.10.1-0.20.20.10.10.00.0
Tibialis anterior weight0.82.64.5-2.1-2.1-1.9-1.91.9-1.8-1.7-1.81.5-1.6-1.4-1.00.2-0.0
Time to tail flick, vehicle, before self-admin0.10.10.2-0.0-0.00.10.1-0.10.20.20.10.2-0.30.3-0.3-0.4-0.5
Time to tail flick, vehicle, after self-admin0.20.20.30.50.50.60.6-0.50.50.60.4-0.50.40.50.5-0.0-0.3
Time to tail flick, test, before self-admin0.20.20.60.0-0.00.20.2-0.20.30.30.40.5-0.50.5-0.5-0.7-0.7
Time to tail flick, test, after self-admin1.92.04.4-1.6-1.7-1.4-1.41.7-1.2-1.1-1.21.9-2.1-0.7-1.7-0.6-0.5
Delta time to tail flick, vehicle, before/after SA0.10.10.50.20.20.20.2-0.40.10.10.0-0.50.50.00.70.40.2
Delta time to tail flick, test, before/after SA1.01.01.9-1.0-1.0-1.1-1.11.2-1.2-1.2-1.40.3-0.5-1.2-0.20.70.9
Tibia length0.61.55.30.40.40.90.9-0.61.21.21.11.3-1.31.6-0.8-1.8-2.3
Ambulatory time before self-admin0.91.44.3-0.8-0.8-0.5-0.40.6-0.0-0.00.12.0-2.10.5-2.0-1.7-1.5
Ambulatory time after self-admin0.60.72.10.00.00.30.3-0.10.60.60.71.1-1.20.9-1.2-1.5-1.4
Bone: tissue strength0.10.10.2-0.3-0.3-0.3-0.30.3-0.4-0.4-0.4-0.10.1-0.40.30.40.1
Total heroin consumption0.00.00.00.00.10.20.2-0.20.20.20.1-0.0-0.10.2-0.1-0.2-0.1
Bone: trabecular number0.30.51.30.30.30.50.5-0.20.60.70.70.6-0.60.9-0.7-1.1-1.1
Bone: trabecular spacing1.01.32.0-1.4-1.4-1.4-1.41.4-1.4-1.4-1.30.6-0.6-1.3-0.30.70.7
Bone: trabecular thickness1.62.03.01.51.51.61.6-1.51.71.71.7-0.30.31.70.0-1.1-1.3
Bone: trabecular tissue density0.60.82.40.40.40.10.1-0.4-0.2-0.2-0.4-1.51.5-0.61.61.51.2
Water consumed over 24 hours1.21.72.9-1.2-1.2-1.5-1.51.3-1.6-1.6-1.6-0.20.2-1.7-0.01.31.6
Number of responses in last shaping day0.20.20.40.60.50.50.5-0.40.50.40.7-0.30.40.3-0.2-0.20.4