Hub : Genes

Ankrd44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Ankrd44 0.04 0.03 2.9e-04 0.04 0.03 0.04 0.04 3.0e-05 5.4e-04 8.8e-05 4.4e-05
2 NAcc gene expression Ankrd44 0.05 0.03 7.1e-05 0.02 0.02 0.02 0.02 1.3e-04 6.3e-04 1.2e-04 3.5e-04
3 pVTA mRNA stability Ankrd44 0.04 0.03 4.1e-03 0.02 0.03 0.02 0.02 1.5e-02 2.2e-03 5.5e-03 1.3e-02
4 Brain gene expression Ankrd44 0.12 0.08 1.4e-05 0.01 0.05 0.06 0.05 3.1e-02 1.6e-05 4.4e-06 4.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density6.210.613.33.7-3.63.2-2.5
Area under the delay curve0.10.10.2-0.4-0.20.1-0.4
BMI with tail3.712.820.1-4.53.5-3.32.8
BMI without tail0.72.12.4-1.31.4-1.51.5
Body weight0.31.33.21.8-0.90.80.5
Weight adjusted by age1.72.63.01.7-1.51.5-1.7
Bone surface5.710.313.23.6-3.33.1-2.8
Bone volume6.611.813.63.7-3.73.4-2.9
Breakpoint value in progressive ratio session0.30.40.50.5-0.50.7-0.7
Number of licking bursts0.10.10.4-0.70.3-0.10.1
Context. condit. distance diff. score2.43.03.2-1.71.7-1.71.8
Locomotion velocity, session 10.20.20.3-0.50.3-0.5-0.2
Locomotion distance, session 10.10.10.3-0.20.4-0.50.2
Locomotion velocity, session 20.20.30.8-0.40.0-0.3-0.9
Locomotion distance, session 20.10.10.2-0.40.4-0.40.1
Locomotion velocity, session 30.50.50.9-0.10.7-0.90.9
Locomotion distance, session 30.20.20.3-0.20.4-0.40.6
Stereotopy head waving bouts, day 32.12.53.2-1.41.7-1.81.5
Stereotopy head waving duration, day 30.81.01.4-0.51.0-1.11.2
Locomotion velocity, session 70.60.72.7-0.2-0.3-0.1-1.7
Locomotion distance, session 70.10.20.6-0.2-0.20.2-0.8
Stereotopy head waving bouts, day 70.40.40.80.7-0.60.5-0.9
Stereotopy head waving duration, day 70.10.10.30.6-0.2-0.1-0.2
Locomotion velocity, session 80.40.41.3-0.3-0.50.4-1.1
Locomotion distance, session 81.42.02.3-1.41.5-1.51.2
Degree of sensitization distance0.80.91.70.3-0.90.9-1.3
Degree of sensitization stereotypy1.01.11.41.0-1.00.9-1.2
Conditioned locomotion0.70.81.21.1-0.91.1-0.2
Cocaine response after cond. corrected4.25.16.41.7-2.42.5-2.2
Cocaine response after cond. not corrected6.07.17.92.2-2.82.8-2.7
Cocaine response before conditioning0.10.10.3-0.10.4-0.5-0.0
Saline control response0.71.02.1-0.60.9-0.91.4
Bone: connectivity density3.85.96.92.6-2.62.3-2.1
Bone: cortical apparent density4.56.18.7-2.92.6-2.31.9
Bone: cortical area0.10.20.30.6-0.30.3-0.3
Bone: cortical porosity2.42.65.22.3-1.51.3-1.1
Bone: cortical porosity3.84.28.02.8-2.01.7-1.3
Bone: cortical thickness1.21.92.2-1.51.5-1.31.3
Bone: cortical thickness0.40.51.3-1.20.1-0.1-0.7
Bone: cortical tissue density4.76.48.9-3.02.7-2.32.0
Condit. Reinf. active minus inactive responses0.80.91.40.5-1.01.2-1.0
Condit. Reinf. active-inactive response ratio0.60.61.30.3-0.80.8-1.1
Condit. Reinf. active responses1.72.23.11.1-1.51.8-1.4
Condit. Reinf. inactive responses0.40.50.90.6-0.80.9-0.5
Incentive salience index mean1.82.22.90.8-1.51.7-1.7
Condit. Reinf. lever presses0.91.21.70.8-1.11.2-1.3
Condit. Reinf. active minus inactive responses4.76.18.42.0-2.72.9-2.2
Condit. Reinf. active-inactive response ratio2.22.53.70.9-1.71.9-1.6
Condit. Reinf. active responses3.44.77.01.5-2.42.6-2.0
Condit. Reinf. inactive responses0.50.60.80.6-0.90.9-0.8
Condit. Reinf. lever presses0.60.81.3-0.3-0.81.1-1.1
Condit. Reinf. lever reinforcers received3.75.17.31.4-2.52.7-2.2
Conditioned reinforcement - actives0.40.71.3-0.50.8-0.71.2
Conditioned reinforcement - inactives0.00.00.10.1-0.20.0-0.2
Conditioned locomotion0.40.61.2-0.80.6-0.31.1
Patch foraging indifference point 0 sec0.51.03.0-0.2-0.60.8-1.7
Patch foraging indifference point AUC0.10.20.20.4-0.50.4-0.5
Delay disc. indifference point, 0s delay1.11.22.5-1.61.0-0.90.6
Delay disc. indifference point, 16s delay0.10.10.30.0-0.40.4-0.5
Delay disc. indifference point, 2s delay0.30.31.2-1.10.00.3-0.3
Delay disc. indifference point, 24s delay0.50.60.6-0.70.8-0.80.8
Delay disc. indifference point, 4s delay0.30.30.8-0.90.5-0.50.3
Delay disc. indifference point, 8s delay0.40.40.70.5-0.70.5-0.9
Indifference point function ln k0.20.30.7-0.90.20.1-0.6
Indifference point function log k0.20.30.7-0.90.20.1-0.6
Patch foraging total patch changes 0 sec0.40.72.0-0.4-0.40.6-1.4
Patch foraging total patch changes 12 sec0.20.30.5-0.1-0.40.7-0.7
Patch foraging total patch changes 18 sec0.40.61.4-1.20.6-0.6-0.6
Patch foraging total patch changes 24 sec0.10.10.20.3-0.30.2-0.4
Patch foraging total patch changes 6 sec0.20.41.1-0.1-0.50.5-1.0
Patch foraging time to switch 0 sec0.20.50.90.20.6-0.90.9
Patch foraging water rate 0 sec0.20.40.60.3-0.50.7-0.8
Patch foraging water rate 12 sec0.51.02.2-0.1-0.81.1-1.5
Patch foraging water rate 18 sec0.40.61.30.7-0.91.1-0.3
Patch foraging water rate 24 sec0.00.00.10.30.1-0.10.1
Patch foraging water rate 6 sec0.00.00.1-0.10.10.10.2
Seeking ratio, delayed vs. immediate footshock1.51.92.81.7-1.41.4-0.9
Distance traveled before self-admin1.21.62.31.5-1.31.3-0.7
Distance traveled after self-admin0.10.20.6-0.70.2-0.10.3
Extensor digitorum longus weight2.39.210.3-3.13.2-3.22.6
Bone: elastic displacement0.10.20.5-0.70.00.20.3
Bone: elastic work0.91.21.71.0-1.21.3-0.6
Bone: endosteal estimation4.39.412.23.5-3.12.9-2.7
Bone: endosteal perimeter3.67.69.73.1-2.72.5-2.6
Epididymis fat weight0.10.20.70.50.0-0.20.8
Delta time in closed arm before/after self-admin0.10.10.2-0.40.4-0.50.0
Delta time in open arm before/after self-admin6.76.67.52.7-2.72.5-2.3
Diff in mean of infusions in LGA sessions0.91.12.20.6-0.90.9-1.5
Delay discount exponential model param0.10.10.10.40.2-0.20.4
Extinction: sum of active levers before priming0.10.10.20.5-0.10.30.3
Active lever presses in extinction session 61.31.32.10.8-1.21.5-1.1
Bone: final force0.50.82.51.6-0.50.50.4
Bone: final moment0.30.51.71.3-0.20.30.5
Food consumed during 24 hour testing period0.20.20.90.20.1-0.00.9
Glucose2.43.87.1-1.31.9-1.72.7
Heart weight0.30.50.80.6-0.60.6-0.9
Delay discount hyperbolic model param0.10.10.20.50.1-0.20.3
Intermittent access intake day 1-15 change1.02.13.5-1.31.4-1.11.9
Intermittent access intake escalation1.32.63.7-1.61.6-1.31.9
Intermittent access intake escalation 20.30.30.9-0.20.5-0.30.9
Intermitt. access day 1 inactive lever presses1.97.08.5-2.92.6-2.42.6
Intermitt. access day 15 inactive lever presses0.40.91.2-1.10.9-0.90.8
Intermitt. access escalation Index0.60.82.50.20.6-0.61.6
Intermittent access day 1 total infusions0.20.20.50.5-0.50.70.0
Intermittent access day 15 total infusions1.11.73.4-1.21.1-0.81.8
Intermittent access terminal intake (last 3 days)1.21.63.2-1.21.1-0.61.8
Intermittent access total infusions0.30.41.2-0.40.4-0.11.1
Intermittent access day 1 locomotion0.00.10.1-0.1-0.20.40.2
Intermittent access day 15 total locomotion0.10.10.40.1-0.40.60.1
Intermittent access total locomotion0.20.20.6-0.50.20.00.8
Intermittent access standard deviation0.30.60.9-1.00.7-0.40.8
Left kidney weight0.10.40.60.7-0.70.8-0.4
Right kidney weight0.20.91.11.0-0.90.9-1.0
Cocaine induced anxiety0.10.10.20.3-0.0-0.2-0.4
Post-drug Anxiety0.00.00.10.2-0.0-0.2-0.1
Baseline Anxiety0.20.20.40.6-0.40.4-0.3
Tail length5.521.642.96.5-4.54.1-2.5
Length with tail5.925.751.57.2-4.94.6-2.5
Length without tail2.78.713.63.7-3.03.0-1.8
Times rat made contact with spout0.20.30.60.00.4-0.50.8
Lifetime Intake0.91.12.6-0.90.9-0.51.6
Liver weight, left1.42.36.62.6-1.31.00.1
Liver weight, right0.50.91.71.3-1.00.9-0.2
Locomotor activity0.00.10.10.3-0.30.3-0.0
Locomotor testing distance0.20.40.60.3-0.70.7-0.7
Locomotor testing rearing0.10.10.20.5-0.40.3-0.3
Locomotion in novel chamber0.60.82.0-1.40.8-0.60.4
Locomotion in novel chamber post-restriction0.81.31.5-1.21.2-1.20.9
Fecal boli incidents, locomotor time 14.36.37.92.3-2.52.4-2.8
Change in fecal boli incidents, locomotor task0.60.60.9-0.70.8-0.60.9
Time >=10cm from walls, locomotor time 13.33.57.70.7-1.81.6-2.8
Bouts of movement, locomotor time 10.60.71.10.5-0.80.8-1.1
Total resting periods, locomotor time 10.20.20.6-0.1-0.40.4-0.8
Rest time, locomotor task time 10.10.10.3-0.30.3-0.30.6
Distance moved, locomotor task time 10.50.70.90.6-0.90.9-0.9
Vertical activity count, locomotor time 10.10.20.5-0.30.6-0.70.2
Time >=10cm from walls, locomotor time 22.63.84.81.1-2.12.1-2.2
Bouts of movement, locomotor time 20.10.20.4-0.7-0.20.3-0.3
Total resting periods, locomotor time 20.10.20.4-0.7-0.10.2-0.4
Rest time, locomotor task time 20.40.60.8-0.50.8-0.90.7
Distance moved, locomotor task time 20.91.11.50.5-1.21.2-1.2
Vertical activity count, locomotor time 20.10.10.4-0.70.2-0.20.1
Light reinforcement 12.66.49.3-2.52.5-1.93.1
Light reinforcement 20.10.10.4-0.2-0.20.70.2
Bone: marrow area4.08.811.33.4-3.02.8-2.7
Bone: maximum diameter1.01.92.41.4-1.31.2-1.5
Bone: maximum force1.32.45.62.4-1.41.3-0.4
Bone: maximum moment0.91.54.02.0-1.01.0-0.2
Mean time between licks in bursts0.71.72.0-1.11.4-1.41.3
Mean num. licks in bursts0.10.10.20.40.0-0.20.4
Cd content in liver0.10.10.20.4-0.20.30.2
Co content in liver0.20.20.3-0.10.5-0.50.4
Cu content in liver0.20.20.40.4-0.50.7-0.2
Fe content in liver1.31.62.11.4-1.31.3-0.9
K content in liver0.10.10.30.1-0.30.3-0.6
Mg content in liver0.30.40.40.6-0.60.6-0.6
Mn content in liver1.61.82.5-1.61.4-1.40.8
Na content in liver1.51.62.01.1-1.41.4-1.1
Rb content in liver1.41.62.30.8-1.31.3-1.5
Se content in liver0.10.10.2-0.1-0.20.40.3
Sr content in liver1.10.92.5-0.00.8-0.71.6
Zn content in liver0.10.10.20.5-0.10.10.2
Bone: minimum diameter0.71.21.61.3-1.01.0-1.0
Time in familiar zone, hab. session 10.30.30.5-0.00.5-0.70.5
Time in novel zone, hab. session 10.20.20.4-0.0-0.50.6-0.6
Total zone transitions, hab. session 10.60.81.90.5-0.80.6-1.4
Total locomotion distance, hab. session 11.01.41.80.8-1.21.3-1.4
Locomotion velocity, hab. session 10.60.91.01.0-0.91.0-0.7
Time in familiar zone, hab. session 20.70.81.3-1.10.7-0.70.8
Time in novel zone, hab. session 20.20.20.40.6-0.40.4-0.3
Total zone transitions, hab. session 20.10.10.20.50.2-0.40.3
Total locomotion distance, hab. session 20.20.20.60.8-0.1-0.00.5
Locomotion velocity, hab. session 20.20.30.91.0-0.1-0.00.4
Novel to familiar place preference ratio1.01.11.61.2-1.11.2-0.3
Novelty place preference1.01.11.61.3-1.11.2-0.3
Time in novel zone, NPP test0.80.91.31.1-1.01.2-0.2
Total zone transitions, NPP test0.10.10.1-0.30.3-0.30.4
Total locomotion distance, NPP test0.10.10.2-0.40.2-0.00.4
Locomotion velocity, NPP test0.10.20.3-0.40.4-0.20.6
Intraocular pressure2.63.74.9-2.22.0-1.81.7
Delta distance traveled before/after self-admin1.31.42.1-1.41.2-1.01.0
Delta ambulatory time before/after self-admin1.11.41.9-1.41.1-0.81.3
Parametrial fat weight0.71.82.3-1.01.4-1.41.5
Pavlov. Cond. lever latency1.51.92.7-0.91.4-1.71.5
Pavlov. Cond. magazine entry latency1.31.72.60.7-1.41.6-1.3
Pavlov. Cond. change in total contacts1.92.13.70.3-1.41.6-1.9
Pavlov. Cond. index score1.01.32.20.7-1.21.5-1.0
Pavlov. Cond. latency score1.62.13.21.0-1.51.8-1.3
Pavlov. Cond. lever contacts1.11.32.00.6-1.11.4-1.2
Pavlov. Cond. magazine entry number1.11.42.2-0.71.3-1.51.1
Pavlov. Cond. intertrial magazine entries0.20.20.60.8-0.50.4-0.0
Pavlov. Cond. lever-magazine prob. diff.1.01.22.00.5-1.21.4-1.1
Pavlov. Cond. response bias0.81.01.50.5-1.11.2-1.0
Pavlov. Cond. lever latency0.50.71.60.40.7-0.71.3
Pavlov. Cond. magazine entry latency0.10.10.3-0.1-0.1-0.2-0.5
Pavlov. Cond. change in total contacts1.01.63.40.1-1.21.3-1.8
Pavlov. Cond. index score0.40.61.3-0.1-0.70.7-1.1
Pavlov. Cond. latency score0.40.51.0-0.1-0.70.6-1.0
Pavlov. Cond. lever contacts0.91.22.4-0.2-1.11.1-1.6
Pavlov. Cond. magazine entry number0.30.40.6-0.50.7-0.60.8
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.30.20.10.3
Pavlov. Cond. lever-magazine prob. diff.0.50.71.6-0.1-0.70.7-1.3
Pavlov. Cond. response bias1.11.52.90.4-1.31.2-1.7
Time in closed arm before self-admin1.92.53.51.9-1.71.6-1.0
Time in closed arm after self-admin1.51.62.60.7-1.31.3-1.6
Time in open arm before self-admin9.310.211.0-3.13.3-3.03.3
Time in open arm after self-admin0.40.40.60.8-0.60.6-0.5
Bone: periosteal estimation2.55.37.12.7-2.22.1-2.1
Bone: periosteal perimeter1.62.73.21.8-1.71.6-1.4
Bone: post-yield work0.40.51.51.2-0.60.5-0.2
Progressive ratio test 1 active lever presses0.50.60.8-0.80.7-0.60.9
Progressive ratio test 1 breakpoint0.20.30.4-0.60.5-0.40.6
Progressive ratio test 1 inactive lever presses6.08.712.0-2.72.9-2.73.5
Progressive ratio test 2 active lever presses0.40.41.0-0.40.6-0.41.0
Progressive ratio test 2 breakpoint0.40.51.0-0.50.6-0.51.0
Progressive ratio test 2 inactive lever presses1.01.63.3-1.11.0-0.91.8
Incentive Sensitization - Responses0.10.20.50.7-0.30.3-0.1
Incentive Sensitization - Breakpoint0.10.10.40.6-0.20.20.0
Sum of active levers in priming session hrs 5-61.31.21.51.2-1.01.2-0.8
Progressive ratio0.30.50.8-0.80.7-0.90.3
Food seeking constrained by brief footshock0.10.10.2-0.10.3-0.40.1
Seeking ratio, punishment vs. effort0.60.91.71.3-0.90.9-0.5
Retroperitoneal fat weight0.41.94.6-0.41.2-1.12.2
Reaction time number correct0.10.20.5-0.70.4-0.30.3
Reaction time mean minus median0.20.51.90.50.3-0.11.4
Reaction time mean minus median AUC0.10.10.40.40.10.10.7
Reaction time num false alarms3.14.45.5-2.32.2-2.11.7
Reaction time num false alarms AUC3.45.36.2-2.52.5-2.31.8
Reaction time trials correct on left0.10.20.5-0.70.4-0.30.3
Reaction time trials on left0.10.20.5-0.70.4-0.30.3
Reaction time mean0.40.61.81.3-0.50.50.5
Reaction time mean AUC0.30.51.01.0-0.10.20.9
Median of all reaction times0.50.72.01.4-0.70.60.1
Reaction time omissions0.40.62.20.30.10.01.5
Reaction time false alarm rate2.02.83.4-1.71.8-1.81.3
Reaction time premature initiation rate0.40.61.4-1.2-0.20.5-0.8
Reaction time premature initiations0.40.62.3-1.50.10.3-0.4
Std. dev. reaction times0.30.61.51.2-0.50.60.5
Reaction time trials completed0.10.20.5-0.70.4-0.30.3
Reaction time trials AUC0.10.30.5-0.70.5-0.40.4
Run reversals in cocaine runway, females0.10.10.20.30.2-0.40.0
Run reversals in cocaine runway, males0.40.40.6-0.2-0.60.7-0.8
Latency to leave start box in cocaine runway4.45.07.4-2.72.2-2.11.7
Latency to leave start box in cocaine runway, F4.85.56.7-2.62.4-2.41.9
Latency to leave start box in cocaine runway, M0.50.51.4-1.20.5-0.60.1
Std. dev. time between licks in bursts3.34.45.5-2.42.1-1.92.0
Total sessions with >9 infusions2.42.94.2-1.71.7-1.32.0
Short access day 1 total inactive lever presses0.40.51.2-1.10.5-0.20.8
Short access day 10 total inactive lever presses0.20.40.7-0.80.6-0.40.6
Short access day 1 total infusions1.62.14.8-1.01.3-1.02.2
Short access day 10 total infusions0.70.92.2-1.00.7-0.31.5
Short access total infusions1.62.03.9-1.41.2-0.82.0
Short access day 1 locomotion1.21.52.2-1.11.1-1.01.5
Short access day 10 total locomotion0.10.31.0-1.00.10.2-0.1
Short access total locomotion1.51.82.6-1.41.2-1.11.6
One hour access (0.3 mA shock)0.20.31.0-0.20.10.31.0
Compulsive drug intake0.60.70.8-0.70.8-0.90.9
One hour access (shock baseline)0.10.20.60.0-0.30.80.4
Social response proportion2.83.14.62.2-1.91.9-0.9
Social responses0.40.61.10.9-0.30.41.1
Social time0.30.41.50.30.3-0.01.2
Soleus weight0.20.50.80.6-0.80.9-0.6
Bone: stiffness1.21.95.82.4-1.00.9-0.2
Tibialis anterior weight0.41.31.7-1.11.2-1.30.8
Time to tail flick, vehicle, before self-admin0.10.10.10.30.2-0.20.1
Time to tail flick, vehicle, after self-admin0.20.20.50.5-0.20.1-0.7
Time to tail flick, test, before self-admin0.50.51.3-1.10.6-0.50.3
Time to tail flick, test, after self-admin0.80.81.1-0.90.9-1.00.8
Delta time to tail flick, vehicle, before/after SA0.10.10.2-0.40.2-0.3-0.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.20.3-0.40.3
Tibia length2.67.316.24.0-2.52.1-1.6
Ambulatory time before self-admin0.50.81.31.1-1.00.9-0.3
Ambulatory time after self-admin0.50.61.3-1.10.6-0.30.9
Bone: tissue strength0.70.71.90.60.5-0.51.4
Total heroin consumption0.10.10.10.3-0.30.4-0.0
Bone: trabecular number3.66.08.52.9-2.72.3-1.8
Bone: trabecular spacing0.20.30.6-0.80.4-0.4-0.3
Bone: trabecular thickness2.32.93.51.7-1.91.8-1.5
Bone: trabecular tissue density0.50.70.9-0.50.9-0.90.9
Water consumed over 24 hours0.20.30.7-0.40.4-0.40.9
Number of responses in last shaping day1.51.72.2-0.91.3-1.41.5