Hub : Genes

Ankrd44

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Ankrd44	0.05	0.03	7.7e-05	0.04	0.03	0.03	0.03	4.7e-05	4.5e-04	1.5e-04	3.9e-04
2	Liver	gene expression	Ankrd44	0.04	0.03	2.1e-04	0.04	0.03	0.04	0.04	2.0e-05	5.8e-04	8.3e-05	3.6e-05
3	Brain	gene expression	Ankrd44	0.13	0.08	6.5e-06	0.04	0.05	0.07	0.05	7.2e-05	1.6e-05	9.6e-07	3.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	7.4	12.4	14.7	3.8	-3.8	2.9
Area under the delay curve	0.1	0.1	0.1	-0.0	0.2	0.4
BMI with tail	3.2	10.3	13.2	-3.6	3.6	-2.2
BMI without tail	0.1	0.3	0.5	-0.4	0.5	-0.7
Body weight	0.5	1.9	3.1	1.7	-1.6	0.4
Weight adjusted by age	1.3	1.5	1.7	1.1	-1.3	1.2
Bone surface	6.9	12.1	14.2	3.8	-3.8	2.8
Bone volume	7.9	13.5	15.5	3.9	-3.9	3.1
Breakpoint value in progressive ratio session	0.0	0.0	0.0	-0.1	0.0	-0.1
Number of licking bursts	0.3	0.4	0.6	-0.7	0.7	-0.2
Context. condit. distance diff. score	1.9	2.3	2.4	-1.5	1.6	-1.5
Locomotion velocity, session 1	0.2	0.3	0.4	-0.6	0.6	0.1
Locomotion distance, session 1	0.0	0.0	0.1	-0.3	0.1	-0.1
Locomotion velocity, session 2	0.2	0.2	0.4	-0.3	0.3	0.6
Locomotion distance, session 2	0.1	0.1	0.1	-0.3	0.3	-0.2
Locomotion velocity, session 3	0.2	0.2	0.7	-0.1	0.0	-0.8
Locomotion distance, session 3	0.1	0.1	0.2	-0.3	0.1	-0.4
Stereotopy head waving bouts, day 3	1.7	2.0	2.2	-1.4	1.3	-1.5
Stereotopy head waving duration, day 3	0.4	0.5	1.0	-0.6	0.5	-1.0
Locomotion velocity, session 7	0.2	0.2	0.6	-0.2	0.2	0.8
Locomotion distance, session 7	0.0	0.0	0.1	-0.0	0.2	0.3
Stereotopy head waving bouts, day 7	0.5	0.6	0.6	0.7	-0.8	0.8
Stereotopy head waving duration, day 7	0.1	0.2	0.2	0.4	-0.5	0.3
Locomotion velocity, session 8	0.2	0.3	0.8	-0.2	0.2	0.9
Locomotion distance, session 8	1.1	1.7	1.9	-1.4	1.3	-1.2
Degree of sensitization distance	0.3	0.3	0.7	0.5	-0.2	0.9
Degree of sensitization stereotypy	0.8	0.9	1.2	0.8	-0.9	1.1
Conditioned locomotion	0.6	0.7	1.1	1.0	-1.0	0.4
Cocaine response after cond. corrected	3.2	3.6	4.8	1.8	-1.7	2.2
Cocaine response after cond. not corrected	4.9	5.5	6.6	2.2	-2.2	2.6
Cocaine response before conditioning	0.0	0.0	0.1	-0.2	0.1	-0.2
Saline control response	0.6	0.7	1.2	-0.7	0.7	-1.1
Bone: connectivity density	4.2	6.5	7.3	2.7	-2.7	2.3
Bone: cortical apparent density	7.2	9.5	11.7	-3.4	3.4	-2.3
Bone: cortical area	0.2	0.2	0.4	0.5	-0.6	0.3
Bone: cortical porosity	3.8	4.2	5.9	2.3	-2.4	1.2
Bone: cortical porosity	5.5	6.0	8.2	2.7	-2.9	1.5
Bone: cortical thickness	1.3	2.1	2.7	-1.6	1.5	-1.2
Bone: cortical thickness	0.5	0.6	1.0	-1.0	0.9	0.1
Bone: cortical tissue density	7.3	9.7	11.9	-3.4	3.5	-2.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.7	0.4	-0.5	0.8
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.3	-0.3	0.9
Condit. Reinf. active responses	1.1	1.3	1.7	1.0	-1.1	1.3
Condit. Reinf. inactive responses	0.3	0.3	0.3	0.6	-0.6	0.5
Incentive salience index mean	0.8	1.0	1.9	0.7	-0.8	1.4
Condit. Reinf. lever presses	0.6	0.8	1.0	0.8	-0.8	1.0
Condit. Reinf. active minus inactive responses	4.0	4.9	5.1	2.3	-2.2	2.2
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.2	1.0	-1.0	1.5
Condit. Reinf. active responses	2.3	3.2	3.7	1.8	-1.7	1.9
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.7	-0.7	0.8
Condit. Reinf. lever presses	0.2	0.3	0.8	-0.1	0.2	0.9
Condit. Reinf. lever reinforcers received	2.5	3.5	4.4	1.8	-1.7	2.1
Conditioned reinforcement - actives	0.2	0.2	0.4	-0.2	0.2	-0.7
Conditioned reinforcement - inactives	0.1	0.1	0.1	0.4	-0.1	0.1
Conditioned locomotion	0.7	0.9	1.1	-0.9	1.1	-0.8
Patch foraging indifference point 0 sec	0.3	0.5	1.0	-0.5	0.4	1.0
Patch foraging indifference point AUC	0.1	0.1	0.1	0.4	-0.3	0.3
Delay disc. indifference point, 0s delay	1.3	1.4	2.0	-1.4	1.4	-0.7
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.1	-0.1	0.5
Delay disc. indifference point, 2s delay	0.6	0.6	1.1	-0.9	1.0	0.1
Delay disc. indifference point, 24s delay	0.4	0.4	0.4	-0.6	0.6	-0.6
Delay disc. indifference point, 4s delay	0.4	0.4	0.6	-0.8	0.7	-0.2
Delay disc. indifference point, 8s delay	0.5	0.5	0.5	0.7	-0.6	0.7
Indifference point function ln k	0.5	0.7	1.1	-1.0	0.9	0.2
Indifference point function log k	0.5	0.7	1.1	-1.0	0.9	0.2
Patch foraging total patch changes 0 sec	0.3	0.5	0.6	-0.8	0.6	0.7
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	-0.4	0.3	0.5
Patch foraging total patch changes 18 sec	0.8	1.0	1.7	-1.3	1.2	0.0
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.1	-0.1	0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.5	-0.2	0.1	0.7
Patch foraging time to switch 0 sec	0.1	0.1	0.4	0.1	-0.1	-0.6
Patch foraging water rate 0 sec	0.0	0.0	0.0	0.2	-0.2	0.2
Patch foraging water rate 12 sec	0.2	0.4	0.9	-0.4	0.3	1.0
Patch foraging water rate 18 sec	0.2	0.3	0.4	0.4	-0.5	0.6
Patch foraging water rate 24 sec	0.0	0.0	0.1	0.2	-0.3	-0.1
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.3	0.2	-0.2
Seeking ratio, delayed vs. immediate footshock	1.6	1.9	2.5	1.5	-1.6	1.0
Distance traveled before self-admin	2.3	2.5	3.1	1.8	-1.6	1.4
Distance traveled after self-admin	0.5	0.6	0.8	-0.8	0.9	-0.5
Extensor digitorum longus weight	2.2	8.5	9.1	-3.0	3.0	-2.7
Bone: elastic displacement	0.3	0.3	0.5	-0.7	0.6	-0.2
Bone: elastic work	1.0	1.3	1.7	1.2	-1.3	0.9
Bone: endosteal estimation	4.8	10.4	12.7	3.5	-3.6	2.5
Bone: endosteal perimeter	4.5	9.2	11.1	3.3	-3.3	2.4
Epididymis fat weight	0.6	1.4	2.3	1.5	-1.4	0.0
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	-0.5	0.5	-0.8
Delta time in open arm before/after self-admin	7.2	7.0	7.5	2.7	-2.7	2.5
Diff in mean of infusions in LGA sessions	0.6	0.7	0.9	0.7	-0.9	1.0
Delay discount exponential model param	0.1	0.1	0.1	0.0	-0.2	-0.4
Extinction: sum of active levers before priming	0.5	0.5	0.8	0.8	-0.9	0.3
Active lever presses in extinction session 6	0.2	0.2	0.3	0.5	-0.4	0.5
Bone: final force	0.7	1.2	1.9	1.3	-1.4	-0.0
Bone: final moment	0.5	0.8	1.2	1.0	-1.1	-0.3
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.1	-0.1	-0.3
Glucose	2.0	2.9	5.3	-1.3	1.4	-2.3
Heart weight	0.0	0.1	0.2	-0.1	0.1	0.4
Delay discount hyperbolic model param	0.1	0.1	0.1	0.2	-0.4	-0.3
Intermittent access intake day 1-15 change	1.1	1.1	1.4	-1.1	0.9	-1.2
Intermittent access intake escalation	0.9	0.9	1.1	-0.9	0.8	-1.0
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.1	-0.2	-0.2
Intermitt. access day 1 inactive lever presses	2.7	2.9	3.6	-1.4	1.8	-1.9
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.2	-0.3	0.4	-0.4
Intermitt. access escalation Index	0.5	0.4	1.2	0.1	-0.2	-1.1
Intermittent access day 1 total infusions	0.2	0.2	0.4	0.6	-0.5	-0.2
Intermittent access day 15 total infusions	0.4	0.5	1.3	-0.2	0.2	-1.1
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.9	-0.3	0.3	-0.9
Intermittent access total infusions	0.2	0.2	0.4	0.3	-0.2	-0.7
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.2	0.4	-0.5
Intermittent access day 15 total locomotion	0.2	0.2	0.3	0.6	-0.5	0.2
Intermittent access total locomotion	0.1	0.1	0.2	0.1	0.1	-0.5
Intermittent access standard deviation	1.4	1.5	2.2	-1.1	1.1	-1.5
Left kidney weight	0.1	0.4	0.5	0.7	-0.6	0.5
Right kidney weight	0.2	0.7	0.8	0.8	-0.9	0.8
Cocaine induced anxiety	0.2	0.3	0.3	-0.6	0.5	-0.4
Post-drug Anxiety	0.0	0.0	0.1	0.0	0.1	0.3
Baseline Anxiety	0.6	0.6	0.7	0.8	-0.7	0.8
Tail length	7.2	21.9	30.5	5.5	-5.4	2.4
Length with tail	8.0	29.4	40.1	6.3	-6.2	3.1
Length without tail	0.9	1.9	2.7	1.6	-1.6	0.8
Times rat made contact with spout	0.1	0.1	0.2	-0.0	0.0	-0.5
Lifetime Intake	0.3	0.3	0.9	-0.1	0.1	-1.0
Liver weight, left	1.7	2.8	3.2	1.8	-1.8	1.4
Liver weight, right	1.3	2.1	2.5	1.6	-1.6	1.2
Locomotor activity	0.1	0.1	0.1	0.4	-0.4	0.0
Locomotor testing distance	0.0	0.1	0.1	0.1	-0.1	0.4
Locomotor testing rearing	0.1	0.2	0.3	0.5	-0.4	0.1
Locomotion in novel chamber	1.5	1.8	2.2	-1.5	1.5	-1.0
Locomotion in novel chamber post-restriction	1.0	1.2	1.6	-1.2	1.3	-0.8
Fecal boli incidents, locomotor time 1	4.5	4.9	5.5	2.1	-2.2	2.3
Change in fecal boli incidents, locomotor task	0.5	0.4	0.6	-0.6	0.5	-0.8
Time >=10cm from walls, locomotor time 1	2.3	2.3	5.4	1.0	-0.8	2.3
Bouts of movement, locomotor time 1	0.4	0.5	0.8	0.5	-0.6	0.9
Total resting periods, locomotor time 1	0.1	0.1	0.3	-0.2	0.1	0.6
Rest time, locomotor task time 1	0.3	0.3	0.4	-0.6	0.5	-0.6
Distance moved, locomotor task time 1	0.4	0.5	0.8	0.6	-0.6	0.9
Vertical activity count, locomotor time 1	0.2	0.2	0.2	-0.4	0.4	-0.5
Time >=10cm from walls, locomotor time 2	2.5	2.7	4.7	1.3	-1.3	2.2
Bouts of movement, locomotor time 2	0.3	0.3	0.4	-0.6	0.6	0.4
Total resting periods, locomotor time 2	0.3	0.3	0.4	-0.6	0.6	0.4
Rest time, locomotor task time 2	0.3	0.3	0.5	-0.5	0.4	-0.7
Distance moved, locomotor task time 2	0.6	0.7	1.4	0.7	-0.6	1.2
Vertical activity count, locomotor time 2	0.2	0.2	0.3	-0.5	0.5	-0.1
Light reinforcement 1	3.5	6.4	6.9	-2.6	2.4	-2.5
Light reinforcement 2	0.0	0.0	0.1	-0.3	0.2	0.0
Bone: marrow area	4.5	9.8	11.8	3.4	-3.4	2.5
Bone: maximum diameter	1.1	2.0	2.4	1.4	-1.6	1.2
Bone: maximum force	1.8	3.1	4.5	2.0	-2.1	0.7
Bone: maximum moment	1.2	2.1	3.2	1.7	-1.8	0.4
Mean time between licks in bursts	0.7	1.0	1.6	-0.8	0.9	-1.3
Mean num. licks in bursts	0.1	0.1	0.2	0.4	-0.5	-0.1
Cd content in liver	0.2	0.2	0.5	0.2	-0.3	-0.7
Co content in liver	0.8	1.0	1.0	-1.0	1.0	-1.0
Cu content in liver	0.1	0.1	0.2	0.3	-0.3	0.4
Fe content in liver	1.3	1.6	2.0	1.4	-1.4	0.8
K content in liver	0.0	0.0	0.0	0.0	-0.0	0.1
Mg content in liver	0.1	0.1	0.2	0.4	-0.4	0.3
Mn content in liver	1.6	1.8	2.4	-1.5	1.4	-1.0
Na content in liver	1.3	1.4	1.8	1.1	-1.0	1.3
Rb content in liver	1.7	2.1	2.9	1.3	-1.3	1.7
Se content in liver	0.1	0.1	0.2	-0.2	0.3	-0.5
Sr content in liver	1.7	1.6	3.7	-0.7	0.7	-1.9
Zn content in liver	0.0	0.0	0.1	-0.1	0.1	-0.2
Bone: minimum diameter	0.7	1.3	1.7	1.2	-1.3	0.8
Time in familiar zone, hab. session 1	0.1	0.0	0.1	-0.1	0.0	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.1	0.1	0.0	0.4
Total zone transitions, hab. session 1	0.3	0.4	1.1	0.3	-0.3	1.0
Total locomotion distance, hab. session 1	0.6	0.8	1.4	0.6	-0.8	1.2
Locomotion velocity, hab. session 1	0.5	0.7	0.9	0.8	-1.0	0.8
Time in familiar zone, hab. session 2	1.0	1.0	1.5	-1.1	1.2	-0.6
Time in novel zone, hab. session 2	0.3	0.3	0.5	0.6	-0.7	0.2
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.2	-0.4	-0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.6	0.6	-0.8	-0.2
Locomotion velocity, hab. session 2	0.4	0.5	1.0	0.8	-1.0	-0.1
Novel to familiar place preference ratio	1.2	1.3	1.7	1.3	-1.2	0.7
Novelty place preference	1.3	1.3	1.8	1.3	-1.3	0.7
Time in novel zone, NPP test	1.0	1.0	1.4	1.2	-1.1	0.6
Total zone transitions, NPP test	0.1	0.1	0.2	-0.4	0.3	-0.3
Total locomotion distance, NPP test	0.1	0.2	0.3	-0.5	0.3	-0.3
Locomotion velocity, NPP test	0.2	0.2	0.3	-0.6	0.4	-0.5
Intraocular pressure	2.9	4.1	5.1	-2.3	2.2	-1.4
Delta distance traveled before/after self-admin	2.6	2.8	3.3	-1.8	1.7	-1.6
Delta ambulatory time before/after self-admin	2.4	2.6	2.9	-1.7	1.5	-1.7
Parametrial fat weight	0.0	0.0	0.0	-0.1	0.0	-0.1
Pavlov. Cond. lever latency	0.6	0.7	1.3	-0.7	0.6	-1.1
Pavlov. Cond. magazine entry latency	0.6	0.7	1.5	0.6	-0.5	1.2
Pavlov. Cond. change in total contacts	0.6	0.6	1.8	0.3	-0.2	1.3
Pavlov. Cond. index score	0.4	0.5	0.9	0.6	-0.5	0.9
Pavlov. Cond. latency score	0.7	0.9	1.4	0.9	-0.8	1.2
Pavlov. Cond. lever contacts	0.3	0.4	0.7	0.6	-0.4	0.8
Pavlov. Cond. magazine entry number	0.7	0.8	1.4	-0.8	0.7	-1.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.9	0.9	-0.9	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	0.4	-0.3	0.9
Pavlov. Cond. response bias	0.3	0.3	0.6	0.5	-0.4	0.8
Pavlov. Cond. lever latency	0.2	0.3	0.9	0.2	-0.2	-1.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	0.1	0.3
Pavlov. Cond. change in total contacts	0.6	0.8	2.3	0.2	-0.2	1.5
Pavlov. Cond. index score	0.2	0.3	0.9	-0.0	0.0	0.9
Pavlov. Cond. latency score	0.2	0.2	0.7	-0.0	0.0	0.8
Pavlov. Cond. lever contacts	0.4	0.6	1.7	0.1	-0.1	1.3
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	-0.6	0.6	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	-0.4	0.4	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.9	-0.1	0.1	1.0
Pavlov. Cond. response bias	0.7	1.0	2.3	0.6	-0.6	1.5
Time in closed arm before self-admin	5.5	6.3	7.4	2.7	-2.7	2.1
Time in closed arm after self-admin	1.8	1.8	2.4	1.3	-1.2	1.6
Time in open arm before self-admin	9.5	10.3	10.5	-3.2	3.2	-3.2
Time in open arm after self-admin	0.3	0.3	0.4	0.7	-0.6	0.4
Bone: periosteal estimation	2.9	5.9	7.5	2.6	-2.7	1.8
Bone: periosteal perimeter	2.1	3.4	4.3	2.0	-2.1	1.4
Bone: post-yield work	0.6	0.8	1.3	1.1	-1.1	0.2
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	-0.1	0.3	-0.9
Progressive ratio test 1 breakpoint	0.2	0.2	0.5	-0.0	0.1	-0.7
Progressive ratio test 1 inactive lever presses	6.5	7.1	12.1	-2.1	2.2	-3.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.1	-0.1	-0.7
Progressive ratio test 2 breakpoint	0.3	0.4	0.9	-0.4	0.4	-0.9
Progressive ratio test 2 inactive lever presses	1.0	1.1	1.9	-0.7	0.9	-1.4
Incentive Sensitization - Responses	0.3	0.3	0.5	0.6	-0.7	-0.0
Incentive Sensitization - Breakpoint	0.2	0.2	0.3	0.5	-0.6	-0.1
Sum of active levers in priming session hrs 5-6	1.0	1.0	1.2	1.1	-1.1	0.7
Progressive ratio	0.7	0.8	1.1	-0.9	1.1	-0.7
Food seeking constrained by brief footshock	0.0	0.0	0.0	0.1	-0.2	-0.2
Seeking ratio, punishment vs. effort	0.9	1.1	1.7	1.1	-1.3	0.6
Retroperitoneal fat weight	0.2	0.5	1.3	-0.3	0.4	-1.1
Reaction time number correct	0.3	0.4	0.6	-0.8	0.7	-0.2
Reaction time mean minus median	0.2	0.3	0.6	0.4	-0.4	-0.8
Reaction time mean minus median AUC	0.1	0.1	0.1	0.4	-0.3	-0.4
Reaction time num false alarms	3.4	4.7	5.8	-2.4	2.2	-1.8
Reaction time num false alarms AUC	4.0	5.5	6.8	-2.6	2.4	-2.0
Reaction time trials correct on left	0.3	0.4	0.6	-0.8	0.7	-0.2
Reaction time trials on left	0.2	0.3	0.5	-0.7	0.6	-0.3
Reaction time mean	0.8	1.1	1.7	1.3	-1.3	0.0
Reaction time mean AUC	0.5	0.6	0.9	1.0	-0.9	-0.4
Median of all reaction times	0.8	1.2	1.8	1.3	-1.3	0.3
Reaction time omissions	0.2	0.2	0.3	0.5	-0.4	-0.5
Reaction time false alarm rate	1.9	2.7	3.3	-1.8	1.7	-1.5
Reaction time premature initiation rate	0.8	1.1	1.6	-1.2	1.3	0.4
Reaction time premature initiations	1.2	1.7	2.5	-1.6	1.6	0.2
Std. dev. reaction times	0.7	1.0	1.6	1.3	-1.2	0.0
Reaction time trials completed	0.2	0.3	0.5	-0.7	0.6	-0.3
Reaction time trials AUC	0.3	0.4	0.6	-0.8	0.7	-0.3
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	-0.0	0.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	-0.2	0.2	0.6
Latency to leave start box in cocaine runway	6.0	6.4	8.1	-2.8	2.8	-1.9
Latency to leave start box in cocaine runway, F	5.2	5.7	7.0	-2.6	2.5	-1.9
Latency to leave start box in cocaine runway, M	0.6	0.6	1.0	-0.9	1.0	-0.2
Std. dev. time between licks in bursts	4.1	4.9	5.4	-2.3	2.3	-2.0
Total sessions with >9 infusions	1.8	2.0	2.9	-1.3	1.2	-1.7
Short access day 1 total inactive lever presses	0.3	0.3	0.5	-0.4	0.7	-0.5
Short access day 10 total inactive lever presses	0.2	0.3	0.4	-0.3	0.6	-0.6
Short access day 1 total infusions	0.6	0.7	1.4	-0.7	0.4	-1.2
Short access day 10 total infusions	0.1	0.1	0.1	0.3	-0.3	-0.2
Short access total infusions	0.5	0.6	1.1	-0.6	0.5	-1.1
Short access day 1 locomotion	0.6	0.7	1.2	-0.6	0.7	-1.1
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	0.2	0.1
Short access total locomotion	0.1	0.1	0.3	0.1	-0.1	-0.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.0	-0.0	-0.3
Compulsive drug intake	0.0	0.0	0.1	-0.2	0.3	-0.0
One hour access (shock baseline)	0.1	0.2	0.2	0.5	-0.5	-0.2
Social response proportion	3.3	3.5	4.6	2.1	-2.1	1.3
Social responses	0.4	0.5	0.7	0.8	-0.9	-0.5
Social time	0.2	0.2	0.5	0.3	-0.2	-0.7
Soleus weight	0.1	0.4	0.4	0.6	-0.6	0.6
Bone: stiffness	2.0	3.1	4.6	2.1	-2.1	0.5
Tibialis anterior weight	0.5	1.8	2.0	-1.4	1.4	-1.2
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.0	-0.2	0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.3	0.5	-0.6	0.6
Time to tail flick, test, before self-admin	0.4	0.4	0.6	-0.7	0.7	-0.2
Time to tail flick, test, after self-admin	1.6	1.6	2.2	-1.1	1.2	-1.5
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	0.1	-0.1
Delta time to tail flick, test, before/after SA	0.6	0.6	0.8	-0.6	0.7	-0.9
Tibia length	4.5	12.6	17.0	4.1	-4.0	2.1
Ambulatory time before self-admin	1.0	1.1	1.4	1.2	-0.9	0.9
Ambulatory time after self-admin	1.7	1.9	2.3	-1.4	1.5	-1.1
Bone: tissue strength	0.4	0.4	0.7	0.5	-0.5	-0.8
Total heroin consumption	0.0	0.0	0.0	0.2	-0.2	-0.0
Bone: trabecular number	4.7	7.3	8.7	2.9	-2.9	2.1
Bone: trabecular spacing	0.3	0.4	0.7	-0.7	0.8	-0.2
Bone: trabecular thickness	2.4	2.9	3.2	1.8	-1.7	1.6
Bone: trabecular tissue density	0.6	0.9	1.4	-0.7	0.8	-1.2
Water consumed over 24 hours	0.4	0.5	0.7	-0.8	0.8	-0.3
Number of responses in last shaping day	2.0	2.1	3.3	-1.2	1.2	-1.8