Hub : Genes

Ankra2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL isoform ratio NM_207595.2 0.05 0.05 1.0e-02 0 0.01 0.01 0.01 2.1e-01 1.2e-02 7.8e-03 2.8e-02
2 NAcc mRNA stability Ankra2 0.14 0.06 0.0e+00 0.21 0.22 0.2 0.21 2.2e-31 6.7e-32 3.1e-30 5.0e-31
3 LHb mRNA stability Ankra2 0.19 0.1 4.4e-04 0.11 0.1 0.09 0.09 1.5e-03 2.0e-03 4.6e-03 3.4e-03
4 Brain mRNA stability Ankra2 0.09 0.04 8.4e-14 0.15 0.09 0.15 0.15 1.6e-13 6.6e-09 5.5e-14 3.5e-14
5 Eye mRNA stability Ankra2 0.51 0.2 7.8e-03 0.07 0.02 0.04 0.14 3.0e-02 1.7e-01 8.4e-02 3.6e-03
6 PL mRNA stability Ankra2 0.06 0.03 2.0e-09 0.09 0.08 0.08 0.08 1.1e-09 3.8e-09 2.3e-09 1.7e-09
7 Adipose mRNA stability Ankra2 0.02 0.01 2.3e-03 0.02 0.01 0.01 0.02 2.6e-03 4.8e-02 6.8e-03 4.0e-03
8 Liver gene expression Ankra2 0.06 0.04 2.8e-07 0.05 0.06 0.05 0.05 5.0e-06 8.2e-07 1.3e-06 1.3e-06
9 IC mRNA stability Ankra2 0.08 0.04 8.6e-05 0.06 0.08 0.06 0.06 1.6e-03 2.2e-04 1.9e-03 1.5e-03
10 pVTA mRNA stability Ankra2 0.11 0.05 2.4e-11 0.14 0.13 0.14 0.15 5.5e-11 7.4e-11 4.0e-11 7.8e-12
11 Liver mRNA stability Ankra2 0.05 0.03 4.5e-05 0.04 0.02 0.03 0.03 2.8e-05 9.1e-04 7.8e-04 4.2e-04
12 BLA mRNA stability Ankra2 0.18 0.08 4.7e-08 0.1 0.1 0.1 0.08 7.2e-06 4.3e-06 1.0e-05 3.6e-05
13 Adipose gene expression Ankra2 0.1 0.04 4.8e-06 0.04 0.04 0.03 0.03 2.9e-05 6.8e-05 2.1e-04 1.9e-04
14 LHb isoform ratio NM_207595.2 0.25 0.14 7.0e-03 0 0.04 0.08 0.08 2.3e-01 4.6e-02 6.7e-03 6.5e-03
15 BLA gene expression Ankra2 0.15 0.08 2.6e-03 0.02 0.02 0.01 0.02 2.3e-02 4.5e-02 1.6e-01 3.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.10.32.1-0.1-0.4-0.6-0.4-1.4-0.4-0.60.4-0.4-0.3-0.2-0.00.1-0.10.2
Area under the delay curve0.60.71.50.70.71.10.80.70.51.2-1.20.90.61.00.8-0.2-0.2-0.9
BMI with tail1.55.011.23.32.42.71.82.12.12.3-2.32.22.11.91.52.22.80.5
BMI without tail1.23.76.92.62.02.12.01.52.21.7-1.82.12.21.61.81.52.20.7
Body weight1.77.213.73.02.63.62.73.72.73.4-3.03.02.52.12.11.42.2-0.0
Weight adjusted by age0.20.32.9-1.0-0.1-0.40.10.20.0-0.40.20.20.20.20.4-1.7-0.50.2
Bone surface0.10.20.60.80.80.60.50.10.20.4-0.70.50.50.50.40.40.1-0.2
Bone volume0.20.40.9-0.4-0.6-0.8-0.7-0.8-0.9-0.90.6-0.7-0.7-0.5-0.70.1-0.40.1
Breakpoint value in progressive ratio session0.10.11.7-0.0-0.3-0.1-0.1-1.3-0.10.20.2-0.3-0.2-0.10.20.00.00.1
Number of licking bursts0.30.52.90.1-0.5-0.2-0.8-1.7-0.8-0.21.0-0.6-0.6-0.5-0.00.80.40.0
Context. condit. distance diff. score1.41.72.6-1.6-1.5-1.3-1.6-0.9-1.5-1.11.5-1.5-1.6-1.5-1.5-0.2-0.70.3
Locomotion velocity, session 10.60.61.4-0.4-1.1-1.0-0.9-0.4-0.8-1.21.1-0.9-0.7-0.8-1.0-0.00.5-0.1
Locomotion distance, session 10.91.11.8-0.6-1.2-1.0-1.3-1.0-1.0-1.11.1-1.3-1.1-1.1-1.30.70.70.7
Locomotion velocity, session 21.01.23.9-1.4-1.3-1.2-0.4-0.6-0.9-1.21.0-0.8-0.8-0.8-0.6-0.7-1.4-2.0
Locomotion distance, session 21.72.44.2-1.1-2.0-1.9-1.8-1.3-1.5-1.92.0-1.9-1.5-1.6-1.80.40.30.8
Locomotion velocity, session 30.20.30.6-0.4-0.6-0.5-0.70.5-0.6-0.40.7-0.4-0.6-0.6-0.7-0.0-0.00.0
Locomotion distance, session 30.10.21.1-0.20.4-0.3-0.11.10.2-0.50.00.10.10.0-0.4-0.6-0.10.3
Stereotopy head waving bouts, day 30.81.02.3-0.7-1.3-0.6-1.2-0.2-1.5-0.40.9-1.1-1.4-1.5-1.20.70.20.0
Stereotopy head waving duration, day 30.30.41.80.1-0.50.7-0.20.2-0.70.8-0.2-0.2-0.6-0.8-0.31.30.6-0.5
Locomotion velocity, session 71.21.32.0-1.2-1.3-1.2-1.1-0.0-1.4-0.91.4-1.1-1.2-1.4-1.3-0.2-1.0-1.0
Locomotion distance, session 70.30.41.1-1.0-0.6-0.5-0.3-0.4-0.5-0.30.7-0.5-0.5-0.6-0.2-0.7-1.1-0.9
Stereotopy head waving bouts, day 71.11.32.6-0.7-1.2-0.6-1.2-1.1-1.6-0.61.2-1.3-1.5-1.6-1.00.9-0.5-0.8
Stereotopy head waving duration, day 70.10.10.60.1-0.3-0.0-0.3-0.2-0.4-0.00.3-0.3-0.4-0.5-0.20.8-0.2-0.6
Locomotion velocity, session 83.84.68.6-2.5-2.5-2.9-2.1-1.3-2.0-2.62.6-2.3-2.1-2.0-2.2-1.0-1.7-1.1
Locomotion distance, session 81.52.24.2-2.0-1.8-1.8-1.6-1.2-1.4-1.51.8-1.7-1.5-1.5-1.5-0.9-0.80.4
Degree of sensitization distance0.70.81.7-0.8-1.3-0.6-0.7-1.3-1.1-0.41.1-1.0-1.0-1.1-0.60.2-0.5-0.6
Degree of sensitization stereotypy0.70.81.6-0.3-0.8-0.4-1.0-1.1-1.2-0.50.9-1.0-1.2-1.2-0.71.0-0.4-0.6
Conditioned locomotion0.40.41.40.81.00.70.40.10.40.6-0.70.30.50.50.20.80.81.2
Cocaine response after cond. corrected0.20.20.50.50.50.20.60.70.60.3-0.40.60.60.70.30.10.40.5
Cocaine response after cond. not corrected0.10.10.90.1-0.10.10.10.90.10.20.00.30.10.2-0.10.10.60.6
Cocaine response before conditioning0.60.71.4-0.6-1.1-0.5-1.20.2-1.2-0.51.0-0.8-1.1-1.2-1.10.20.0-0.2
Saline control response0.20.21.10.60.70.60.10.00.20.6-0.50.30.20.30.20.30.21.1
Bone: connectivity density0.30.51.21.10.80.70.7-0.80.50.8-0.80.50.60.61.00.70.3-0.2
Bone: cortical apparent density1.01.42.3-0.8-1.3-1.4-1.4-0.7-1.3-1.51.4-1.3-1.2-1.5-1.40.1-0.10.6
Bone: cortical area0.40.62.0-0.6-0.3-0.6-0.81.2-1.0-0.60.0-0.5-0.7-0.7-1.4-0.1-1.0-0.5
Bone: cortical porosity2.62.910.11.2-1.10.2-1.70.6-1.20.40.6-1.0-1.3-1.2-1.93.22.73.2
Bone: cortical porosity3.33.510.40.5-1.7-0.4-2.30.2-2.0-0.11.2-1.8-2.0-1.9-2.63.22.12.6
Bone: cortical thickness0.81.34.1-0.8-0.9-1.2-1.60.4-1.7-1.10.8-1.2-1.3-1.1-2.0-0.1-0.60.4
Bone: cortical thickness0.50.53.10.2-0.10.1-0.41.8-0.9-0.0-0.1-0.2-0.6-0.9-1.11.0-0.5-0.4
Bone: cortical tissue density1.01.42.3-0.8-1.4-1.4-1.3-0.7-1.2-1.41.4-1.3-1.2-1.5-1.40.2-0.10.7
Condit. Reinf. active minus inactive responses0.60.72.9-0.7-0.8-0.4-0.6-1.7-1.0-0.40.6-0.7-0.8-0.90.10.0-1.0-1.0
Condit. Reinf. active-inactive response ratio0.20.20.9-0.2-0.3-0.1-0.3-1.0-0.5-0.10.3-0.3-0.4-0.40.20.4-0.4-0.4
Condit. Reinf. active responses0.60.72.7-0.9-0.9-0.5-0.5-1.6-0.8-0.50.7-0.6-0.8-0.80.2-0.5-1.1-1.1
Condit. Reinf. inactive responses0.40.52.9-1.2-0.3-0.30.2-0.30.1-0.30.0-0.0-0.10.10.4-1.7-1.2-1.1
Incentive salience index mean0.50.62.7-1.0-0.80.0-0.3-1.6-0.80.00.4-0.4-0.7-0.80.5-0.7-0.9-1.3
Condit. Reinf. lever presses0.30.42.2-1.2-0.50.0-0.1-1.0-0.3-0.00.1-0.1-0.3-0.40.6-1.5-0.5-0.9
Condit. Reinf. active minus inactive responses0.91.22.2-1.5-1.2-1.5-0.9-1.1-1.0-1.31.3-0.8-0.7-0.8-0.6-1.5-1.40.1
Condit. Reinf. active-inactive response ratio0.20.21.2-0.2-0.6-0.7-0.50.0-0.4-0.40.7-0.2-0.1-0.1-0.5-0.20.11.1
Condit. Reinf. active responses0.91.33.1-1.6-1.1-1.5-1.0-1.0-1.0-1.31.3-0.7-0.7-0.8-0.6-1.8-1.10.3
Condit. Reinf. inactive responses0.20.21.8-0.70.30.20.3-0.20.20.1-0.30.40.20.10.5-1.3-0.6-0.4
Condit. Reinf. lever presses0.60.91.4-0.9-1.0-1.2-1.0-1.2-0.8-1.11.2-0.7-0.7-0.6-0.6-0.9-0.31.1
Condit. Reinf. lever reinforcers received0.60.82.6-1.1-0.8-1.3-0.8-0.8-0.7-1.11.1-0.5-0.4-0.4-0.5-1.6-0.70.7
Conditioned reinforcement - actives2.64.48.82.33.01.52.61.92.71.5-2.12.32.82.82.0-0.00.50.5
Conditioned reinforcement - inactives0.30.51.50.91.20.21.01.01.00.0-0.60.50.90.90.20.20.10.1
Conditioned locomotion1.21.64.61.42.10.31.42.11.60.5-1.11.21.71.40.50.1-0.10.4
Patch foraging indifference point 0 sec0.81.63.7-0.41.21.01.51.51.11.0-1.01.51.21.21.4-1.9-1.1-1.1
Patch foraging indifference point AUC0.50.81.41.10.91.10.80.00.91.2-0.90.91.01.00.90.20.9-0.4
Delay disc. indifference point, 0s delay2.93.25.1-1.7-2.2-1.6-1.8-2.0-2.2-1.51.9-1.8-2.0-2.1-1.3-0.8-1.8-1.7
Delay disc. indifference point, 16s delay1.11.22.10.81.40.91.31.41.21.0-1.51.21.31.40.9-0.2-0.1-0.6
Delay disc. indifference point, 2s delay0.60.63.0-0.7-0.6-0.3-0.1-0.1-0.6-0.1-0.0-0.1-0.40.00.2-1.4-1.7-1.7
Delay disc. indifference point, 24s delay2.02.24.00.91.41.91.70.51.62.0-1.81.81.71.81.9-0.60.8-0.1
Delay disc. indifference point, 4s delay0.80.81.80.2-1.2-0.2-0.9-1.0-1.2-0.30.6-0.9-1.3-1.0-0.71.4-0.3-0.9
Delay disc. indifference point, 8s delay0.91.13.90.60.91.71.01.10.62.0-1.41.00.81.00.9-0.10.3-0.6
Indifference point function ln k0.20.31.60.70.0-0.2-0.20.8-0.2-0.10.1-0.1-0.1-0.2-0.51.30.30.9
Indifference point function log k0.20.31.60.70.0-0.2-0.20.8-0.2-0.10.1-0.1-0.1-0.2-0.51.30.30.9
Patch foraging total patch changes 0 sec0.91.74.0-0.51.21.11.61.51.11.1-1.11.51.21.21.4-2.0-1.2-1.2
Patch foraging total patch changes 12 sec0.60.81.70.91.01.30.90.70.71.3-1.01.10.80.90.90.00.70.0
Patch foraging total patch changes 18 sec0.40.62.5-0.40.50.60.60.80.40.6-0.50.70.40.40.5-1.2-1.0-1.6
Patch foraging total patch changes 24 sec1.01.76.40.91.51.61.32.51.31.6-1.51.51.21.10.70.10.60.1
Patch foraging total patch changes 6 sec0.91.42.80.31.21.51.50.61.31.2-1.21.51.21.21.7-1.0-0.2-1.2
Patch foraging time to switch 0 sec0.30.62.6-1.6-0.8-0.3-0.7-0.1-0.7-0.50.4-0.6-0.9-1.0-0.4-1.1-0.90.0
Patch foraging water rate 0 sec0.20.51.51.20.70.60.70.90.50.8-0.40.60.60.50.21.20.70.5
Patch foraging water rate 12 sec1.12.27.61.4-0.6-0.7-1.71.3-1.3-0.41.1-0.9-1.0-0.9-2.22.81.72.2
Patch foraging water rate 18 sec0.81.34.92.20.90.50.21.50.50.6-0.30.70.70.8-0.21.91.91.0
Patch foraging water rate 24 sec0.91.33.71.91.11.10.31.80.51.2-0.80.60.50.4-0.31.91.40.8
Patch foraging water rate 6 sec0.81.24.30.3-0.9-0.8-1.21.2-1.4-0.70.9-1.0-1.0-1.4-2.11.30.20.5
Seeking ratio, delayed vs. immediate footshock0.40.53.50.80.70.50.5-1.90.50.1-0.40.10.60.50.90.40.40.5
Distance traveled before self-admin0.20.20.60.8-0.30.8-0.4-0.0-0.40.70.0-0.1-0.6-0.3-0.10.70.6-0.5
Distance traveled after self-admin0.70.92.30.40.91.31.00.11.10.7-0.81.21.11.11.5-0.90.5-0.3
Extensor digitorum longus weight0.10.42.10.00.60.60.41.40.40.5-0.60.50.40.60.0-0.50.60.7
Bone: elastic displacement1.92.212.01.0-1.1-0.8-1.30.5-0.8-0.50.9-1.0-0.6-0.7-1.82.22.23.5
Bone: elastic work1.31.78.11.1-0.6-0.3-1.01.1-0.5-0.10.3-0.6-0.4-0.7-1.52.02.42.8
Bone: endosteal estimation0.20.32.2-0.10.30.20.51.50.30.3-0.40.40.20.10.10.0-0.6-1.2
Bone: endosteal perimeter0.10.21.10.30.10.00.20.3-0.0-0.2-0.10.0-0.10.1-0.01.0-0.5-1.0
Epididymis fat weight1.65.611.43.22.42.82.13.42.42.4-2.32.52.22.11.61.52.41.2
Delta time in closed arm before/after self-admin0.10.10.8-0.3-0.2-0.5-0.0-0.9-0.20.20.3-0.5-0.0-0.2-0.1-0.2-0.30.4
Delta time in open arm before/after self-admin0.10.10.50.40.30.20.20.70.2-0.5-0.20.50.30.20.30.10.2-0.1
Diff in mean of infusions in LGA sessions0.20.20.5-0.4-0.7-0.3-0.5-0.4-0.60.10.3-0.6-0.7-0.6-0.50.1-0.10.1
Delay discount exponential model param0.80.91.7-0.8-0.8-1.2-1.0-0.8-0.7-1.31.3-1.0-0.8-1.2-1.00.20.20.9
Extinction: sum of active levers before priming0.20.22.00.3-0.30.10.1-1.40.00.40.3-0.10.0-0.00.50.20.2-0.0
Active lever presses in extinction session 62.02.03.71.31.91.41.70.51.71.5-1.91.51.71.81.5-0.20.30.1
Bone: final force0.81.23.5-0.7-1.3-0.8-1.40.8-1.4-0.80.7-1.1-1.3-1.7-1.90.60.20.4
Bone: final moment0.61.03.3-0.4-1.0-0.5-1.21.2-1.2-0.50.4-0.9-1.1-1.6-1.80.80.50.5
Food consumed during 24 hour testing period0.10.21.40.70.1-0.0-0.1-0.1-0.20.00.20.20.00.50.20.60.1-1.2
Glucose2.43.87.0-2.0-2.3-2.6-2.1-1.5-2.0-2.62.1-2.1-2.1-2.0-2.1-0.1-1.40.5
Heart weight1.42.26.51.71.11.91.01.11.02.5-1.41.31.20.91.11.02.41.5
Delay discount hyperbolic model param0.60.61.3-0.6-0.6-1.0-0.8-0.5-0.5-1.11.1-0.8-0.6-1.0-0.80.30.41.0
Intermittent access intake day 1-15 change0.10.20.80.80.3-0.6-0.10.40.0-0.90.3-0.10.10.2-0.40.7-0.10.2
Intermittent access intake escalation0.10.20.90.60.2-0.7-0.10.10.0-1.00.3-0.10.20.2-0.30.4-0.20.4
Intermittent access intake escalation 20.10.10.50.70.5-0.40.10.50.2-0.70.10.10.30.3-0.20.3-0.20.2
Intermitt. access day 1 inactive lever presses0.20.61.6-0.9-0.3-1.3-0.60.1-0.6-1.10.9-0.9-0.6-0.8-1.3-0.5-0.7-0.1
Intermitt. access day 15 inactive lever presses0.40.92.0-0.7-0.9-1.4-0.9-1.0-0.9-1.31.2-1.1-0.9-1.1-1.00.3-0.50.1
Intermitt. access escalation Index0.60.91.70.1-1.3-1.1-1.0-0.3-1.0-0.91.1-0.8-1.1-1.1-1.01.30.00.3
Intermittent access day 1 total infusions4.16.612.53.53.02.63.02.62.92.7-2.52.72.82.62.31.61.50.1
Intermittent access day 15 total infusions1.21.96.32.51.71.01.51.51.50.8-1.31.31.51.31.01.30.70.4
Intermittent access terminal intake (last 3 days)1.41.86.42.51.70.91.41.31.50.8-1.21.21.51.40.91.40.70.3
Intermittent access total infusions2.32.77.02.62.11.51.81.81.81.4-1.71.61.81.61.21.50.90.3
Intermittent access day 1 locomotion1.92.44.51.81.81.71.61.91.62.1-1.91.61.61.41.11.00.80.3
Intermittent access day 15 total locomotion2.54.610.22.32.62.02.33.22.32.4-2.32.32.42.31.50.80.90.1
Intermittent access total locomotion2.22.67.12.21.91.31.62.71.71.7-1.71.61.81.60.91.20.70.3
Intermittent access standard deviation0.10.20.80.90.60.40.60.00.60.4-0.40.40.60.50.50.30.20.2
Left kidney weight4.621.333.75.25.15.84.84.24.95.6-5.15.14.84.74.52.13.60.7
Right kidney weight4.018.431.34.44.85.64.74.54.65.3-5.14.84.44.14.11.32.90.3
Cocaine induced anxiety0.20.31.4-0.20.31.00.2-0.30.11.2-1.00.40.10.10.8-0.50.10.5
Post-drug Anxiety0.80.93.30.10.71.60.70.60.61.8-1.61.00.50.51.1-0.20.40.4
Baseline Anxiety0.10.10.9-0.1-0.10.10.10.90.10.0-0.00.1-0.0-0.1-0.3-0.00.1-0.2
Tail length0.31.03.30.60.61.41.41.81.01.4-0.91.10.80.41.00.3-0.2-0.5
Length with tail0.93.911.40.81.72.62.43.42.02.5-2.32.31.81.61.8-0.7-0.0-0.7
Length without tail0.51.76.50.41.12.01.22.50.81.9-1.71.40.80.90.9-0.6-0.1-1.0
Times rat made contact with spout1.51.76.22.51.21.40.5-0.30.71.1-0.91.21.21.41.31.42.10.5
Lifetime Intake2.63.17.32.72.21.62.01.82.01.6-1.81.71.91.81.41.61.00.3
Liver weight, left1.01.73.71.81.11.91.01.50.91.7-1.51.40.91.21.01.11.2-0.0
Liver weight, right1.42.55.02.11.82.21.51.91.31.8-1.81.61.41.11.11.31.3-0.0
Locomotor activity0.10.20.90.50.10.3-0.20.5-0.4-0.00.10.10.0-0.1-0.20.20.60.9
Locomotor testing distance0.91.63.01.01.71.21.41.71.20.8-1.21.71.71.51.2-1.00.10.3
Locomotor testing rearing0.61.23.11.81.81.21.11.00.70.8-1.11.11.31.10.8-0.10.40.3
Locomotion in novel chamber0.20.21.00.3-0.2-1.0-0.3-0.6-0.3-0.60.6-0.4-0.2-0.4-0.30.5-0.3-0.1
Locomotion in novel chamber post-restriction0.20.20.8-0.2-0.5-0.1-0.5-0.9-0.20.30.3-0.5-0.5-0.4-0.20.70.80.6
Fecal boli incidents, locomotor time 10.20.30.70.40.90.80.60.10.50.6-0.80.60.70.50.7-0.20.40.1
Change in fecal boli incidents, locomotor task0.20.21.30.90.1-0.5-0.0-0.70.4-0.00.4-0.20.20.3-0.11.20.40.3
Time >=10cm from walls, locomotor time 10.80.82.51.21.00.10.41.01.10.6-0.30.40.70.8-0.01.31.31.6
Bouts of movement, locomotor time 10.10.10.2-0.2-0.50.1-0.3-0.3-0.30.20.20.0-0.3-0.30.20.1-0.1-0.3
Total resting periods, locomotor time 10.10.10.3-0.2-0.30.3-0.2-0.2-0.20.6-0.00.2-0.2-0.30.30.10.0-0.2
Rest time, locomotor task time 10.91.12.0-0.3-1.3-0.9-1.4-0.2-1.0-0.81.3-1.1-1.2-1.3-1.21.30.61.0
Distance moved, locomotor task time 11.11.73.00.21.70.81.70.41.60.8-1.41.31.51.61.6-1.5-0.7-0.9
Vertical activity count, locomotor time 10.71.64.7-0.11.50.81.6-0.21.30.5-1.41.11.31.51.4-2.2-1.2-1.3
Time >=10cm from walls, locomotor time 20.20.30.60.60.60.40.30.70.60.5-0.40.50.50.50.20.60.80.7
Bouts of movement, locomotor time 20.10.10.7-0.80.0-0.00.20.10.3-0.1-0.20.30.10.40.4-0.3-0.3-0.3
Total resting periods, locomotor time 20.10.21.0-1.0-0.5-0.4-0.3-0.4-0.2-0.40.3-0.1-0.40.00.2-0.2-0.5-0.4
Rest time, locomotor task time 21.62.03.3-0.5-1.6-1.4-1.7-1.2-1.7-1.61.8-1.6-1.7-1.6-1.31.2-0.8-0.7
Distance moved, locomotor task time 20.81.01.90.61.31.01.11.01.31.0-1.41.11.10.90.9-0.30.60.5
Vertical activity count, locomotor time 20.40.61.11.01.10.60.70.50.90.5-0.90.71.01.00.40.10.60.7
Light reinforcement 10.51.22.40.91.41.51.00.71.01.5-1.31.31.21.31.00.20.6-0.0
Light reinforcement 21.01.54.31.41.11.60.71.00.71.7-1.30.90.90.90.61.32.11.3
Bone: marrow area0.10.32.0-0.10.20.20.51.40.20.3-0.40.30.1-0.00.00.1-0.7-1.3
Bone: maximum diameter0.40.72.90.30.90.70.81.70.40.6-1.10.80.50.50.30.2-0.8-1.5
Bone: maximum force0.20.41.7-0.3-0.5-0.5-0.71.3-0.6-0.50.2-0.3-0.5-0.8-1.10.10.10.3
Bone: maximum moment0.20.42.8-0.1-0.3-0.3-0.51.7-0.4-0.2-0.0-0.1-0.3-0.6-1.10.30.30.4
Mean time between licks in bursts0.00.10.2-0.4-0.30.50.20.4-0.20.5-0.30.1-0.20.00.1-0.1-0.2-0.3
Mean num. licks in bursts0.60.91.80.81.00.90.91.21.00.8-1.41.21.21.20.8-0.50.5-0.0
Cd content in liver0.30.41.2-0.2-0.4-0.4-0.8-0.3-0.8-0.30.4-0.6-0.6-0.4-0.90.70.11.1
Co content in liver0.20.20.70.30.30.10.00.80.30.1-0.00.50.40.70.1-0.50.70.8
Cu content in liver0.20.21.6-0.6-0.1-0.1-0.0-0.7-0.10.00.10.10.00.10.4-1.3-0.00.2
Fe content in liver2.42.95.3-0.8-1.7-1.3-2.3-1.3-2.2-1.41.6-2.1-2.3-2.0-2.21.5-0.20.7
K content in liver0.40.40.80.10.70.70.30.20.40.7-0.90.60.40.80.7-0.8-0.5-0.4
Mg content in liver0.60.61.3-0.6-0.6-0.8-1.1-0.4-1.0-0.90.6-0.9-1.0-0.8-1.10.1-0.60.4
Mn content in liver2.73.04.8-1.4-1.7-1.9-2.1-0.7-2.2-2.11.7-1.9-2.1-1.8-2.10.5-1.50.3
Na content in liver0.40.51.20.20.81.00.70.10.50.8-1.10.60.40.40.8-0.8-0.4-0.6
Rb content in liver0.50.53.90.70.40.2-0.20.50.30.0-0.20.20.20.5-0.30.81.42.0
Se content in liver1.51.82.9-1.5-1.3-1.5-1.4-0.9-1.5-1.71.4-1.3-1.5-1.2-1.2-0.7-1.6-1.1
Sr content in liver0.40.43.1-0.20.0-0.40.10.3-0.0-0.50.10.10.00.10.0-0.3-1.4-1.8
Zn content in liver0.40.41.30.50.80.40.4-0.10.60.5-0.60.60.71.10.5-0.40.71.0
Bone: minimum diameter1.42.65.3-1.8-1.4-1.9-1.80.3-1.9-2.11.3-1.7-1.9-1.5-2.3-0.4-1.6-0.5
Time in familiar zone, hab. session 10.70.73.71.3-0.00.3-0.50.4-0.00.60.0-0.0-0.20.2-0.41.61.41.9
Time in novel zone, hab. session 11.71.76.2-0.21.10.71.80.21.30.4-0.81.31.41.21.8-1.4-1.1-2.5
Total zone transitions, hab. session 10.70.92.2-0.6-0.9-1.0-0.8-1.2-1.0-1.51.1-1.1-0.9-1.3-0.80.3-0.5-0.5
Total locomotion distance, hab. session 10.40.61.6-0.3-0.9-0.8-0.9-0.2-0.9-1.31.0-0.9-0.8-1.0-1.10.40.20.0
Locomotion velocity, hab. session 10.91.32.8-0.5-1.2-1.0-1.4-0.5-1.3-1.41.2-1.4-1.3-1.5-1.70.70.30.4
Time in familiar zone, hab. session 23.03.26.02.51.91.61.52.41.91.7-1.71.71.81.90.71.31.62.0
Time in novel zone, hab. session 21.51.65.1-1.8-1.1-0.8-0.5-1.9-1.1-0.60.8-0.9-1.0-1.20.1-1.2-1.6-2.3
Total zone transitions, hab. session 20.20.21.0-0.7-0.1-0.20.2-0.50.2-0.30.2-0.10.1-0.20.3-1.0-0.5-0.8
Total locomotion distance, hab. session 20.10.21.3-0.7-0.2-0.5-0.2-0.30.2-0.60.3-0.20.00.0-0.1-1.1-0.00.1
Locomotion velocity, hab. session 20.20.21.0-0.7-0.3-0.6-0.3-0.40.1-0.70.5-0.3-0.1-0.1-0.2-1.00.00.1
Novel to familiar place preference ratio0.10.11.2-0.40.1-0.10.1-0.5-0.0-0.0-0.1-0.10.1-0.10.2-1.1-0.4-0.0
Novelty place preference0.20.21.8-0.50.1-0.10.2-0.4-0.00.1-0.1-0.00.1-0.10.3-1.3-0.8-0.5
Time in novel zone, NPP test0.20.21.3-0.50.0-0.10.1-0.6-0.10.1-0.1-0.1-0.0-0.20.2-1.1-0.8-0.4
Total zone transitions, NPP test1.11.53.0-1.0-1.7-1.1-1.3-1.4-1.4-1.31.4-1.5-1.3-1.7-1.20.40.20.3
Total locomotion distance, NPP test1.62.23.3-1.2-1.8-1.6-1.8-1.1-1.7-1.81.8-1.8-1.6-1.8-1.70.1-0.20.4
Locomotion velocity, NPP test1.62.33.4-1.2-1.8-1.5-1.8-1.0-1.7-1.81.8-1.8-1.7-1.8-1.70.1-0.20.3
Intraocular pressure2.63.86.3-1.8-2.0-2.2-1.9-2.0-2.1-2.22.2-2.5-2.0-2.4-2.20.0-1.2-0.8
Delta distance traveled before/after self-admin0.70.71.70.51.00.61.20.21.30.2-0.81.11.31.11.20.00.30.0
Delta ambulatory time before/after self-admin0.40.51.30.40.80.41.0-0.21.00.1-0.60.91.10.91.1-0.10.2-0.0
Parametrial fat weight0.41.04.21.6-0.00.6-0.10.80.10.4-0.20.10.1-0.3-0.42.02.01.5
Pavlov. Cond. lever latency0.10.20.40.2-0.5-0.6-0.40.1-0.3-0.50.7-0.4-0.4-0.4-0.60.3-0.2-0.1
Pavlov. Cond. magazine entry latency1.31.73.4-0.01.11.71.60.51.21.8-1.41.41.11.21.8-1.0-0.6-1.6
Pavlov. Cond. change in total contacts0.80.94.8-0.80.50.70.8-0.20.40.7-0.90.50.40.61.0-1.3-1.4-2.2
Pavlov. Cond. index score1.11.42.8-0.41.01.41.40.21.01.5-1.41.20.91.01.6-1.3-0.8-1.7
Pavlov. Cond. latency score0.91.12.2-0.31.01.31.20.20.91.4-1.31.10.91.01.5-1.1-0.5-1.2
Pavlov. Cond. lever contacts0.30.41.7-1.20.20.10.3-0.30.10.1-0.50.10.00.10.5-1.3-1.0-0.9
Pavlov. Cond. magazine entry number3.03.86.9-0.3-1.8-2.3-2.4-1.1-2.0-2.52.1-2.2-1.9-1.9-2.61.50.72.2
Pavlov. Cond. intertrial magazine entries0.50.61.4-0.7-0.9-0.9-0.7-0.8-0.7-1.20.6-0.8-0.8-0.9-0.6-0.1-0.60.5
Pavlov. Cond. lever-magazine prob. diff.1.11.34.0-0.80.81.11.30.10.81.2-1.11.00.70.81.5-1.6-1.2-2.0
Pavlov. Cond. response bias1.41.73.6-0.31.11.51.60.91.11.6-1.51.41.11.11.7-1.2-0.9-1.9
Pavlov. Cond. lever latency0.40.61.70.40.70.90.71.30.90.9-1.00.60.60.50.30.50.90.2
Pavlov. Cond. magazine entry latency1.11.32.41.31.31.01.31.31.11.1-1.21.51.41.51.2-0.10.3-0.5
Pavlov. Cond. change in total contacts0.50.71.5-0.6-1.0-1.0-1.0-0.2-1.2-0.71.0-0.9-1.0-0.9-1.1-0.2-0.8-0.2
Pavlov. Cond. index score0.00.10.30.30.1-0.20.10.3-0.10.00.10.30.20.30.2-0.4-0.6-0.3
Pavlov. Cond. latency score0.20.20.40.60.50.10.40.50.30.3-0.20.70.60.60.5-0.4-0.4-0.2
Pavlov. Cond. lever contacts0.70.92.5-0.6-1.0-1.2-1.0-1.6-1.2-1.11.3-0.9-0.9-0.8-0.5-0.3-1.0-0.1
Pavlov. Cond. magazine entry number0.60.71.4-1.2-1.0-0.8-0.8-1.1-0.6-0.90.9-1.0-0.9-0.9-0.6-0.3-0.20.2
Pavlov. Cond. intertrial magazine entries0.30.51.9-1.3-0.4-0.4-0.2-0.1-0.3-0.50.3-0.4-0.6-0.1-0.2-1.0-1.4-1.1
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.30.1-0.20.10.2-0.1-0.00.10.30.20.30.2-0.3-0.5-0.3
Pavlov. Cond. response bias0.20.31.0-0.1-0.5-0.7-0.6-1.0-0.8-0.60.7-0.5-0.5-0.4-0.3-0.1-0.6-0.1
Time in closed arm before self-admin1.11.42.9-0.5-1.5-1.5-1.5-0.5-1.4-1.71.2-1.2-1.4-1.3-1.40.9-0.4-0.1
Time in closed arm after self-admin1.31.42.7-1.2-1.7-1.5-1.4-0.7-1.4-1.21.3-1.4-1.4-1.3-1.30.1-0.60.0
Time in open arm before self-admin2.72.95.40.82.01.82.1-0.22.02.1-1.51.72.12.12.3-1.60.5-0.2
Time in open arm after self-admin1.61.73.70.91.71.51.7-0.01.60.8-1.11.61.71.71.9-0.80.6-0.1
Bone: periosteal estimation0.20.42.9-0.3-0.0-0.3-0.31.7-0.5-0.2-0.1-0.2-0.4-0.5-1.00.3-1.0-0.9
Bone: periosteal perimeter0.20.31.6-0.20.2-0.00.21.2-0.2-0.2-0.50.1-0.10.0-0.40.2-1.1-1.3
Bone: post-yield work0.20.31.0-0.60.30.40.50.30.40.2-0.70.40.30.20.5-1.0-0.7-0.6
Progressive ratio test 1 active lever presses1.11.42.41.41.51.21.51.41.50.9-1.31.21.41.31.00.50.50.1
Progressive ratio test 1 breakpoint1.11.42.31.41.51.11.41.51.50.8-1.31.21.41.40.90.50.50.2
Progressive ratio test 1 inactive lever presses1.92.76.22.52.21.01.91.42.00.8-1.51.72.11.91.21.40.70.3
Progressive ratio test 2 active lever presses3.64.211.83.42.71.72.41.52.51.2-2.02.12.52.21.91.40.90.2
Progressive ratio test 2 breakpoint3.43.810.93.32.61.62.31.32.41.1-1.92.02.42.11.81.30.90.2
Progressive ratio test 2 inactive lever presses2.64.211.23.32.81.62.52.12.51.1-2.02.02.52.31.51.20.9-0.2
Incentive Sensitization - Responses2.43.412.43.52.21.62.00.32.00.8-1.51.92.11.82.01.91.20.0
Incentive Sensitization - Breakpoint2.63.412.63.52.21.52.00.32.00.8-1.51.82.11.81.92.01.20.0
Sum of active levers in priming session hrs 5-60.60.64.00.9-0.5-0.0-0.5-0.9-0.60.50.5-0.6-0.6-0.8-0.32.00.60.1
Progressive ratio0.00.00.2-0.20.10.10.1-0.40.1-0.40.00.10.10.10.20.20.0-0.1
Food seeking constrained by brief footshock1.01.36.12.0-0.10.4-0.41.20.00.10.20.10.1-0.0-0.82.52.11.5
Seeking ratio, punishment vs. effort0.50.72.71.3-0.40.1-0.61.2-0.40.40.2-0.2-0.3-0.3-0.91.61.30.9
Retroperitoneal fat weight0.31.14.31.90.31.00.11.90.31.0-0.30.70.30.3-0.12.11.40.8
Reaction time number correct0.71.33.1-1.4-1.1-1.4-1.40.6-1.2-0.91.1-1.2-1.3-1.0-1.8-0.7-0.9-0.5
Reaction time mean minus median0.51.12.0-0.5-1.4-1.2-1.1-0.6-1.2-1.01.4-1.1-1.1-1.0-0.91.1-0.3-1.2
Reaction time mean minus median AUC0.20.41.6-0.0-0.8-0.6-0.70.0-0.6-0.40.8-0.6-0.7-0.6-0.71.30.3-0.7
Reaction time num false alarms0.30.41.20.50.80.80.50.50.80.7-1.10.70.50.50.50.30.50.3
Reaction time num false alarms AUC0.60.92.01.01.11.30.60.90.91.1-1.40.90.70.60.60.91.00.7
Reaction time trials correct on left0.71.33.1-1.4-1.1-1.4-1.40.6-1.2-0.91.1-1.2-1.3-1.0-1.8-0.7-0.9-0.5
Reaction time trials on left0.81.53.5-1.5-1.2-1.5-1.50.5-1.3-1.11.2-1.3-1.4-1.1-1.9-0.7-0.9-0.5
Reaction time mean1.52.55.2-1.5-1.8-2.3-1.5-1.5-1.6-2.22.0-1.7-1.5-1.2-1.3-0.2-1.2-0.9
Reaction time mean AUC1.11.74.0-1.3-1.5-2.0-1.2-1.2-1.2-2.01.7-1.4-1.2-1.0-1.1-0.2-1.0-0.7
Median of all reaction times1.21.73.9-1.3-1.5-2.0-1.3-1.1-1.3-2.01.6-1.4-1.2-1.0-1.2-0.4-1.1-0.5
Reaction time omissions1.62.34.6-1.6-1.8-1.9-1.8-1.4-1.6-2.11.7-1.6-1.6-1.6-1.4-0.6-0.4-0.3
Reaction time false alarm rate1.21.73.31.51.41.81.20.31.31.4-1.71.31.10.91.41.11.20.9
Reaction time premature initiation rate3.04.18.41.92.22.12.22.92.22.1-1.72.52.42.21.80.41.50.8
Reaction time premature initiations0.91.77.90.91.41.01.22.81.41.2-0.81.61.51.40.6-0.20.80.4
Std. dev. reaction times1.01.93.5-0.8-1.7-1.9-1.4-1.4-1.4-1.91.9-1.5-1.3-1.3-1.10.8-0.3-0.8
Reaction time trials completed0.81.53.5-1.5-1.2-1.5-1.50.5-1.3-1.11.2-1.3-1.4-1.1-1.9-0.7-0.9-0.5
Reaction time trials AUC0.71.43.3-1.5-1.1-1.5-1.50.5-1.2-1.11.1-1.2-1.3-1.0-1.8-0.8-0.9-0.5
Run reversals in cocaine runway, females0.20.21.2-0.70.4-0.50.20.30.6-0.10.10.20.50.50.3-1.1-0.20.3
Run reversals in cocaine runway, males0.50.54.31.4-0.0-0.2-0.3-0.6-0.2-0.50.3-0.5-0.3-0.1-0.32.10.60.4
Latency to leave start box in cocaine runway0.30.41.5-1.0-0.80.1-0.5-0.8-0.7-0.10.1-0.6-0.8-1.2-0.4-0.30.10.2
Latency to leave start box in cocaine runway, F0.20.20.8-0.20.40.80.5-0.10.30.5-0.90.40.4-0.20.5-0.8-0.1-0.2
Latency to leave start box in cocaine runway, M1.61.53.1-1.4-1.8-1.0-1.4-1.2-1.4-0.81.4-1.4-1.5-1.5-1.00.0-0.10.5
Std. dev. time between licks in bursts0.50.71.80.40.71.21.0-0.20.71.2-1.00.90.80.91.3-0.30.2-0.7
Total sessions with >9 infusions1.41.74.72.21.50.91.41.51.61.1-1.01.21.51.50.91.50.70.4
Short access day 1 total inactive lever presses0.30.41.00.80.70.70.90.00.80.9-1.00.50.60.70.60.40.30.2
Short access day 10 total inactive lever presses0.10.30.9-1.0-0.1-0.6-0.5-0.5-0.4-0.90.5-0.5-0.4-0.5-0.7-0.4-0.4-0.2
Short access day 1 total infusions1.11.42.81.61.50.81.60.51.70.9-1.01.11.51.31.20.70.50.3
Short access day 10 total infusions0.70.92.31.31.10.70.81.50.90.7-0.70.60.91.00.11.50.50.2
Short access total infusions1.51.94.72.21.61.21.61.21.71.2-1.21.21.51.51.01.60.80.2
Short access day 1 locomotion1.41.73.21.61.80.51.51.71.81.1-1.21.51.81.70.90.20.20.5
Short access day 10 total locomotion1.22.25.3-1.4-1.3-2.0-1.9-0.0-1.6-1.21.7-1.8-1.6-1.6-2.30.2-1.00.3
Short access total locomotion0.20.32.40.40.4-0.3-0.11.60.20.5-0.10.00.20.1-0.70.6-0.20.5
One hour access (0.3 mA shock)3.13.510.73.32.51.72.11.12.11.2-1.81.72.12.01.61.71.10.1
Compulsive drug intake0.50.55.40.70.20.30.3-2.30.3-0.3-0.20.20.50.31.20.10.2-0.1
One hour access (shock baseline)1.21.85.22.21.71.01.32.31.31.1-1.31.21.21.20.31.50.60.2
Social response proportion4.95.59.2-3.0-2.6-2.8-2.5-2.4-2.3-2.82.6-2.7-2.4-2.3-2.3-1.6-1.2-0.5
Social responses1.11.45.7-2.0-0.8-1.5-0.8-0.9-0.7-1.51.2-1.0-0.6-0.6-0.9-2.4-0.9-0.1
Social time0.81.22.8-1.4-1.1-1.5-1.0-0.6-1.1-1.71.2-1.0-0.8-0.6-1.1-1.2-0.50.3
Soleus weight0.61.88.10.11.31.41.32.81.41.4-1.71.31.10.80.6-1.10.6-0.9
Bone: stiffness0.20.41.6-1.0-0.4-0.3-0.20.4-0.4-0.30.0-0.2-0.5-0.7-0.3-0.7-1.1-1.3
Tibialis anterior weight1.55.07.5-2.3-2.5-2.6-2.6-2.1-2.4-2.62.5-2.7-2.4-2.4-2.4-0.20.10.8
Time to tail flick, vehicle, before self-admin0.40.42.70.50.60.70.41.60.30.4-0.80.60.40.50.1-0.10.2-0.3
Time to tail flick, vehicle, after self-admin0.91.23.92.01.21.20.7-0.20.61.7-1.20.70.70.80.91.80.7-0.2
Time to tail flick, test, before self-admin0.70.73.51.0-0.5-0.8-0.90.1-0.8-0.51.0-0.7-0.7-0.8-1.01.90.10.1
Time to tail flick, test, after self-admin0.91.02.5-0.6-0.9-1.4-1.2-1.6-1.2-1.01.1-1.1-1.0-0.9-0.5-0.2-0.70.2
Delta time to tail flick, vehicle, before/after SA0.30.31.50.70.30.20.1-1.20.10.7-0.40.10.20.30.41.20.20.2
Delta time to tail flick, test, before/after SA0.50.53.0-1.7-0.4-0.3-0.3-0.9-0.4-0.30.1-0.4-0.4-0.30.2-1.7-0.60.1
Tibia length0.10.31.20.1-0.20.5-0.31.1-0.20.6-0.5-0.2-0.4-0.6-0.80.80.20.5
Ambulatory time before self-admin0.10.10.60.1-0.30.8-0.3-0.0-0.30.80.00.1-0.4-0.10.2-0.10.5-0.4
Ambulatory time after self-admin0.10.20.7-0.10.10.60.3-0.50.30.0-0.20.50.30.40.8-0.40.3-0.2
Bone: tissue strength0.30.32.8-1.0-0.3-0.50.1-0.20.2-0.60.00.10.30.30.2-1.7-0.20.2
Total heroin consumption0.80.94.3-0.5-1.1-0.5-1.0-2.1-0.9-0.40.8-1.1-1.1-1.1-0.60.5-0.2-0.0
Bone: trabecular number0.10.21.80.20.1-0.20.2-1.3-0.0-0.3-0.00.00.10.20.60.1-0.4-0.7
Bone: trabecular spacing1.52.04.7-0.8-1.6-1.2-2.00.2-1.7-1.41.6-1.6-1.9-1.6-2.20.8-0.00.7
Bone: trabecular thickness1.62.03.1-1.3-1.6-1.5-1.4-1.6-1.7-1.41.3-1.8-1.6-1.7-1.50.0-1.0-0.3
Bone: trabecular tissue density0.71.02.2-0.8-1.5-0.8-1.3-0.7-1.1-0.61.2-1.0-1.1-1.3-1.00.00.71.2
Water consumed over 24 hours1.01.34.22.01.01.20.50.10.71.1-0.61.11.01.11.11.32.00.3
Number of responses in last shaping day0.50.61.71.11.10.80.81.30.70.5-0.60.70.80.80.40.00.4-0.1