Hub : Genes

Anapc11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Anapc11	0.21	0.11	6.7e-15	0.14	0.13	0.12	0.14	2.9e-15	1.8e-14	2.9e-13	4.1e-15
2	Liver	mRNA stability	Anapc11	0.11	0.07	1.1e-09	0.09	0.09	0.07	0.08	7.5e-10	8.4e-10	9.6e-09	2.7e-09
3	PL	gene expression	Anapc11	0.04	0.03	8.7e-04	0.02	0.02	0.02	0.02	3.1e-03	1.3e-03	1.3e-03	2.1e-03
4	Adipose	mRNA stability	Anapc11	0.03	0.02	6.3e-03	0.01	0.01	0	0.01	6.9e-02	2.1e-02	7.7e-02	2.8e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.5	0.6	0.7	0.7	-0.8	0.7
Area under the delay curve	1.2	1.4	2.2	-1.5	-1.5	1.1	-0.2
BMI with tail	0.8	2.6	3.3	1.7	1.7	-1.8	1.3
BMI without tail	3.2	9.9	12.1	3.4	3.4	-3.5	2.2
Body weight	2.6	11.2	15.8	4.0	4.0	-3.4	1.2
Weight adjusted by age	1.8	2.7	3.7	1.9	1.9	-1.8	0.5
Bone surface	0.1	0.2	0.4	0.6	0.6	-0.3	-0.0
Bone volume	0.2	0.4	0.6	0.8	0.8	-0.6	0.3
Breakpoint value in progressive ratio session	0.4	0.4	1.0	0.5	0.5	-0.4	-1.0
Number of licking bursts	0.2	0.3	0.6	0.5	0.5	-0.4	0.8
Context. condit. distance diff. score	2.1	2.5	4.8	1.0	1.0	-1.7	2.2
Locomotion velocity, session 1	3.8	4.1	4.9	-2.0	-2.0	2.2	-2.0
Locomotion distance, session 1	1.7	2.1	3.5	-1.9	-1.9	1.1	0.6
Locomotion velocity, session 2	5.1	5.9	7.6	-2.8	-2.8	2.6	-1.2
Locomotion distance, session 2	0.3	0.4	0.9	-0.7	-0.7	0.0	0.9
Locomotion velocity, session 3	2.3	2.6	3.4	-1.7	-1.7	1.8	-1.2
Locomotion distance, session 3	3.0	3.3	4.5	-2.1	-2.1	1.9	-0.6
Stereotopy head waving bouts, day 3	0.8	1.0	1.4	-0.9	-0.9	1.2	-0.9
Stereotopy head waving duration, day 3	0.5	0.6	0.8	-0.8	-0.8	0.9	-0.5
Locomotion velocity, session 7	0.4	0.5	0.7	-0.9	-0.9	0.7	0.1
Locomotion distance, session 7	1.6	2.0	3.0	-1.7	-1.7	0.8	1.2
Stereotopy head waving bouts, day 7	0.2	0.2	0.3	0.6	0.6	-0.5	0.1
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.7	0.7	-0.4	0.1
Locomotion velocity, session 8	0.5	0.6	1.6	-0.6	-0.6	-0.1	1.3
Locomotion distance, session 8	2.4	3.4	9.5	0.6	0.6	-1.8	3.1
Degree of sensitization distance	1.3	1.3	1.8	0.9	0.9	-1.4	1.3
Degree of sensitization stereotypy	0.5	0.6	0.8	0.8	0.8	-0.9	0.5
Conditioned locomotion	5.0	5.7	7.3	2.5	2.5	-2.7	1.8
Cocaine response after cond. corrected	0.2	0.2	0.6	-0.4	-0.4	0.4	-0.8
Cocaine response after cond. not corrected	0.6	0.7	0.8	-0.9	-0.9	0.9	-0.8
Cocaine response before conditioning	0.5	0.6	0.9	-0.9	-0.9	0.8	0.5
Saline control response	2.6	3.5	4.6	2.1	2.1	-2.0	1.0
Bone: connectivity density	0.2	0.3	0.9	0.1	0.1	-0.3	1.0
Bone: cortical apparent density	2.4	3.2	4.5	-2.1	-2.1	1.9	-0.7
Bone: cortical area	4.3	6.7	10.5	3.2	3.2	-2.4	0.2
Bone: cortical porosity	1.1	1.2	4.1	0.5	0.5	0.5	-2.0
Bone: cortical porosity	1.0	1.1	2.7	0.9	0.9	-0.0	-1.7
Bone: cortical thickness	3.1	5.2	8.6	2.9	2.9	-1.8	-0.6
Bone: cortical thickness	0.9	1.1	1.7	1.3	1.3	-1.0	-0.1
Bone: cortical tissue density	2.7	3.6	5.0	-2.2	-2.2	2.0	-0.8
Condit. Reinf. active minus inactive responses	2.4	2.6	3.4	1.8	1.8	-1.8	0.8
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.5	1.2	1.2	-1.2	0.5
Condit. Reinf. active responses	4.2	5.2	6.5	2.5	2.5	-2.5	1.2
Condit. Reinf. inactive responses	1.0	1.2	1.6	1.2	1.2	-1.3	0.6
Incentive salience index mean	2.0	2.4	2.9	1.7	1.7	-1.7	0.9
Condit. Reinf. lever presses	0.2	0.3	0.9	0.3	0.3	-0.5	0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.7	0.7	-0.9	0.5
Condit. Reinf. active-inactive response ratio	1.1	1.2	1.9	1.4	1.4	-1.1	-0.2
Condit. Reinf. active responses	0.2	0.3	0.5	0.2	0.2	-0.7	0.7
Condit. Reinf. inactive responses	0.4	0.5	0.8	-0.9	-0.9	0.3	0.5
Condit. Reinf. lever presses	0.6	0.8	1.4	0.5	0.5	-1.2	1.2
Condit. Reinf. lever reinforcers received	0.4	0.5	1.1	0.3	0.3	-1.0	1.0
Conditioned reinforcement - actives	0.0	0.1	0.1	-0.2	-0.2	0.1	0.4
Conditioned reinforcement - inactives	0.2	0.3	0.6	0.5	0.5	-0.7	0.3
Conditioned locomotion	0.0	0.1	0.2	0.0	0.0	-0.2	0.4
Patch foraging indifference point 0 sec	0.1	0.2	0.2	0.5	0.5	-0.4	0.2
Patch foraging indifference point AUC	0.0	0.1	0.2	0.0	0.0	-0.3	0.4
Delay disc. indifference point, 0s delay	0.0	0.0	0.0	0.1	0.1	-0.1	0.2
Delay disc. indifference point, 16s delay	0.9	1.0	1.3	-1.2	-1.2	0.4	1.1
Delay disc. indifference point, 2s delay	0.5	0.6	0.8	-0.9	-0.9	0.7	-0.5
Delay disc. indifference point, 24s delay	5.3	6.0	7.4	-2.7	-2.7	2.6	-1.5
Delay disc. indifference point, 4s delay	0.4	0.4	0.5	-0.6	-0.6	0.7	-0.4
Delay disc. indifference point, 8s delay	1.1	1.2	1.4	-1.2	-1.2	1.2	-1.0
Indifference point function ln k	0.4	0.6	0.9	-1.0	-1.0	0.8	0.1
Indifference point function log k	0.4	0.6	0.9	-1.0	-1.0	0.8	0.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.5	0.5	-0.6	0.4
Patch foraging total patch changes 12 sec	0.0	0.0	0.1	0.2	0.2	-0.1	-0.4
Patch foraging total patch changes 18 sec	0.2	0.4	1.0	-0.1	-0.1	-0.6	1.0
Patch foraging total patch changes 24 sec	0.7	1.2	1.6	1.1	1.1	-1.3	0.6
Patch foraging total patch changes 6 sec	0.2	0.3	0.4	0.6	0.6	-0.4	-0.3
Patch foraging time to switch 0 sec	0.3	0.7	0.9	-0.9	-0.9	1.0	-0.4
Patch foraging water rate 0 sec	1.9	3.9	5.6	2.0	2.0	-2.4	1.3
Patch foraging water rate 12 sec	0.6	1.3	2.0	0.8	0.8	-1.4	1.4
Patch foraging water rate 18 sec	1.3	2.0	2.7	1.2	1.2	-1.6	1.6
Patch foraging water rate 24 sec	3.8	5.3	7.9	1.9	1.9	-2.8	2.4
Patch foraging water rate 6 sec	0.3	0.4	0.8	0.4	0.4	-0.7	0.9
Seeking ratio, delayed vs. immediate footshock	1.2	1.5	1.9	1.4	1.4	-1.3	0.6
Distance traveled before self-admin	0.6	0.8	1.2	1.1	1.1	-0.8	-0.4
Distance traveled after self-admin	1.2	1.5	2.0	1.2	1.2	-1.4	1.0
Extensor digitorum longus weight	0.5	1.9	4.3	0.7	0.7	-1.5	2.1
Bone: elastic displacement	0.9	1.1	1.7	1.3	1.3	-0.9	-0.2
Bone: elastic work	4.4	5.7	9.0	3.0	3.0	-1.8	-1.3
Bone: endosteal estimation	0.2	0.4	1.4	0.1	0.1	-0.6	1.2
Bone: endosteal perimeter	0.5	1.0	1.7	1.3	1.3	-0.9	0.1
Epididymis fat weight	1.7	5.9	6.9	2.6	2.6	-2.6	1.7
Delta time in closed arm before/after self-admin	0.3	0.3	1.1	-0.1	-0.1	-0.1	1.0
Delta time in open arm before/after self-admin	0.0	0.0	0.0	0.0	0.0	-0.1	0.1
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	0.3	0.3	-0.1	-0.6
Delay discount exponential model param	2.2	2.4	3.4	1.8	1.8	-1.6	0.6
Extinction: sum of active levers before priming	0.5	0.6	0.8	-0.7	-0.7	0.9	-0.7
Active lever presses in extinction session 6	2.0	2.0	4.4	-1.0	-1.0	1.3	-2.1
Bone: final force	5.0	7.9	11.6	3.4	3.4	-2.8	0.7
Bone: final moment	5.5	8.8	13.2	3.6	3.6	-2.9	0.4
Food consumed during 24 hour testing period	0.4	0.6	0.7	0.8	0.8	-0.8	0.4
Glucose	11.2	17.6	21.3	-3.8	-3.8	4.5	-4.6
Heart weight	0.5	0.7	1.0	1.0	1.0	-0.8	-0.4
Delay discount hyperbolic model param	2.0	2.3	3.2	1.8	1.8	-1.5	0.7
Intermittent access intake day 1-15 change	0.2	0.4	0.6	0.6	0.6	-0.4	-0.8
Intermittent access intake escalation	0.2	0.3	0.5	0.6	0.6	-0.4	-0.7
Intermittent access intake escalation 2	0.9	1.0	1.4	1.1	1.1	-0.6	-1.2
Intermitt. access day 1 inactive lever presses	1.0	3.7	5.4	1.9	1.9	-2.3	1.4
Intermitt. access day 15 inactive lever presses	0.8	1.6	2.3	1.0	1.0	-1.5	1.4
Intermitt. access escalation Index	0.6	0.9	1.1	0.8	0.8	-1.0	1.0
Intermittent access day 1 total infusions	0.0	0.1	0.1	0.3	0.3	-0.3	0.2
Intermittent access day 15 total infusions	0.3	0.4	0.5	0.7	0.7	-0.7	0.1
Intermittent access terminal intake (last 3 days)	0.4	0.6	0.8	0.9	0.9	-0.8	-0.1
Intermittent access total infusions	0.2	0.2	0.3	0.5	0.5	-0.5	0.2
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.0	0.0	-0.1	0.3
Intermittent access day 15 total locomotion	0.1	0.3	0.4	0.6	0.6	-0.5	-0.1
Intermittent access total locomotion	0.1	0.1	0.2	0.3	0.3	-0.4	0.1
Intermittent access standard deviation	0.6	1.3	2.9	-0.8	-0.8	1.1	-1.7
Left kidney weight	0.0	0.2	0.7	0.1	0.1	0.4	-0.8
Right kidney weight	0.0	0.1	0.4	0.1	0.1	0.4	-0.6
Cocaine induced anxiety	0.8	1.1	3.7	0.6	0.6	-0.1	-1.9
Post-drug Anxiety	1.4	1.5	4.6	-0.5	-0.5	0.8	-2.1
Baseline Anxiety	1.5	1.8	2.6	-1.6	-1.6	1.4	-0.4
Tail length	2.9	11.3	16.1	4.0	4.0	-3.4	1.1
Length with tail	1.1	4.8	8.0	2.8	2.8	-1.7	-0.7
Length without tail	0.4	1.3	4.4	0.5	0.5	0.5	-2.1
Times rat made contact with spout	0.6	0.7	1.4	0.8	0.8	-0.2	-1.2
Lifetime Intake	0.0	0.0	0.0	0.1	0.1	-0.1	0.0
Liver weight, left	0.7	1.2	1.9	-1.0	-1.0	1.4	-1.0
Liver weight, right	2.3	4.0	5.5	2.3	2.3	-1.9	1.1
Locomotor activity	0.6	0.9	1.3	-1.1	-1.1	1.0	-0.3
Locomotor testing distance	0.7	1.3	2.1	-1.5	-1.5	1.0	0.3
Locomotor testing rearing	0.2	0.4	0.6	-0.8	-0.8	0.3	0.6
Locomotion in novel chamber	0.1	0.2	0.3	-0.4	-0.4	0.1	0.6
Locomotion in novel chamber post-restriction	2.1	3.4	5.1	2.3	2.3	-1.8	0.3
Fecal boli incidents, locomotor time 1	0.2	0.3	0.4	-0.6	-0.6	0.4	0.4
Change in fecal boli incidents, locomotor task	3.2	3.2	4.2	-1.6	-1.6	1.9	-2.0
Time >=10cm from walls, locomotor time 1	1.4	1.5	2.0	1.1	1.1	-1.1	1.4
Bouts of movement, locomotor time 1	1.4	1.5	1.9	-1.4	-1.4	1.4	-0.7
Total resting periods, locomotor time 1	2.1	2.3	2.9	-1.6	-1.6	1.7	-1.0
Rest time, locomotor task time 1	1.0	1.2	1.6	-1.0	-1.0	1.2	-1.3
Distance moved, locomotor task time 1	0.6	0.8	1.0	1.0	1.0	-0.9	0.7
Vertical activity count, locomotor time 1	0.9	2.2	2.4	1.5	1.5	-1.5	1.4
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	0.1	0.1	-0.1
Bouts of movement, locomotor time 2	0.5	0.9	1.3	-1.1	-1.1	0.9	-0.0
Total resting periods, locomotor time 2	0.2	0.4	0.7	-0.8	-0.8	0.5	0.4
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.2	-0.2	0.4	-0.2
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.1	0.1	-0.1	0.2
Vertical activity count, locomotor time 2	0.2	0.3	0.9	0.3	0.3	-0.6	0.9
Light reinforcement 1	1.6	4.0	4.4	1.9	1.9	-2.1	2.1
Light reinforcement 2	2.5	3.9	4.9	2.2	2.2	-1.9	1.4
Bone: marrow area	0.2	0.4	1.3	0.1	0.1	-0.6	1.2
Bone: maximum diameter	1.1	2.0	3.3	1.8	1.8	-1.1	0.1
Bone: maximum force	4.8	8.4	12.0	3.5	3.5	-3.0	0.9
Bone: maximum moment	5.1	8.9	13.1	3.6	3.6	-3.0	0.6
Mean time between licks in bursts	0.7	1.6	2.4	-1.6	-1.6	1.3	-0.1
Mean num. licks in bursts	0.2	0.3	1.2	0.1	0.1	0.0	-1.1
Cd content in liver	0.5	0.6	1.5	-0.6	-0.6	-0.3	1.2
Co content in liver	0.0	0.0	0.0	0.2	0.2	0.0	-0.1
Cu content in liver	0.6	0.7	0.9	0.9	0.9	-0.2	-1.0
Fe content in liver	0.2	0.2	0.3	-0.6	-0.6	0.2	0.5
K content in liver	2.6	2.5	3.2	1.4	1.4	-1.6	1.8
Mg content in liver	2.0	2.1	5.2	0.8	0.8	-1.4	2.3
Mn content in liver	0.1	0.1	0.1	0.3	0.3	-0.2	0.2
Na content in liver	0.2	0.2	0.7	0.1	0.1	-0.3	0.8
Rb content in liver	2.9	3.3	4.5	1.7	1.7	-2.1	1.8
Se content in liver	0.4	0.5	0.7	0.7	0.7	-0.8	0.6
Sr content in liver	1.2	1.0	2.3	-0.6	-0.6	1.0	-1.5
Zn content in liver	1.3	1.4	1.8	1.4	1.4	-1.2	0.7
Bone: minimum diameter	2.7	4.9	7.7	2.8	2.8	-2.0	0.2
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.6
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.2	0.2	-0.2	0.5
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.5	-0.5	0.1	0.5
Total locomotion distance, hab. session 1	0.5	0.6	1.2	0.5	0.5	-0.9	1.1
Locomotion velocity, hab. session 1	0.5	0.7	1.3	0.6	0.6	-0.9	1.1
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.5	-0.5	0.1	0.3
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.1
Total zone transitions, hab. session 2	0.8	1.0	3.5	-0.2	-0.2	-0.8	1.9
Total locomotion distance, hab. session 2	1.9	2.4	5.4	0.9	0.9	-1.7	2.3
Locomotion velocity, hab. session 2	2.1	2.8	5.3	1.2	1.2	-1.9	2.3
Novel to familiar place preference ratio	1.6	1.8	2.7	1.6	1.6	-1.1	-0.8
Novelty place preference	1.5	1.6	2.4	1.6	1.6	-1.0	-0.9
Time in novel zone, NPP test	1.3	1.4	2.0	1.4	1.4	-1.0	-0.6
Total zone transitions, NPP test	1.0	1.4	5.1	-0.3	-0.3	-0.7	2.2
Total locomotion distance, NPP test	1.9	2.5	7.3	0.5	0.5	-1.5	2.7
Locomotion velocity, NPP test	1.6	2.2	5.4	0.7	0.7	-1.5	2.3
Intraocular pressure	0.9	1.2	2.0	1.1	1.1	-1.4	0.9
Delta distance traveled before/after self-admin	0.2	0.2	0.7	-0.2	-0.2	-0.1	0.8
Delta ambulatory time before/after self-admin	0.5	0.6	0.7	-0.8	-0.8	0.4	0.9
Parametrial fat weight	0.7	1.7	1.9	1.4	1.4	-1.4	1.0
Pavlov. Cond. lever latency	0.8	1.0	2.6	-0.8	-0.8	-0.3	1.6
Pavlov. Cond. magazine entry latency	1.2	1.6	2.1	1.5	1.5	-0.6	-1.3
Pavlov. Cond. change in total contacts	0.7	0.7	2.5	0.2	0.2	0.5	-1.6
Pavlov. Cond. index score	1.8	2.3	3.7	1.9	1.9	-1.0	-0.9
Pavlov. Cond. latency score	1.4	1.8	2.6	1.6	1.6	-0.5	-1.2
Pavlov. Cond. lever contacts	0.5	0.6	0.8	0.9	0.9	-0.1	-0.8
Pavlov. Cond. magazine entry number	1.4	1.8	3.6	-1.3	-1.3	0.3	1.9
Pavlov. Cond. intertrial magazine entries	0.9	1.0	1.9	0.7	0.7	-1.2	1.4
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.6	1.9	1.9	-1.0	-0.8
Pavlov. Cond. response bias	1.1	1.4	2.6	1.2	1.2	-0.2	-1.6
Pavlov. Cond. lever latency	1.7	2.3	3.4	-1.2	-1.2	1.8	-1.7
Pavlov. Cond. magazine entry latency	0.9	1.1	1.6	-1.3	-1.3	0.4	1.1
Pavlov. Cond. change in total contacts	0.3	0.4	1.3	-0.2	-0.2	-0.6	1.1
Pavlov. Cond. index score	0.3	0.4	1.3	-0.1	-0.1	-0.6	1.1
Pavlov. Cond. latency score	0.4	0.6	1.7	-0.1	-0.1	-0.7	1.3
Pavlov. Cond. lever contacts	1.4	2.0	2.9	1.0	1.0	-1.7	1.7
Pavlov. Cond. magazine entry number	0.6	0.7	1.1	0.9	0.9	-0.2	-1.0
Pavlov. Cond. intertrial magazine entries	1.3	2.0	2.5	1.6	1.6	-1.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	-0.4	-0.4	-0.4	1.0
Pavlov. Cond. response bias	0.5	0.6	1.6	0.2	0.2	-0.9	1.3
Time in closed arm before self-admin	0.6	0.8	1.6	-0.6	-0.6	1.0	-1.3
Time in closed arm after self-admin	1.6	1.7	2.1	-1.2	-1.2	1.5	-1.4
Time in open arm before self-admin	0.4	0.4	1.4	0.2	0.2	-0.5	1.2
Time in open arm after self-admin	0.3	0.3	0.8	0.2	0.2	-0.5	0.9
Bone: periosteal estimation	1.5	3.1	4.4	2.1	2.1	-1.8	0.7
Bone: periosteal perimeter	2.0	3.4	5.5	2.4	2.4	-1.1	-1.2
Bone: post-yield work	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.6
Progressive ratio test 1 active lever presses	0.3	0.4	0.5	0.7	0.7	-0.7	0.3
Progressive ratio test 1 breakpoint	0.4	0.5	0.6	0.8	0.8	-0.7	0.3
Progressive ratio test 1 inactive lever presses	3.3	4.7	6.1	2.2	2.2	-2.5	1.7
Progressive ratio test 2 active lever presses	0.2	0.2	0.3	0.4	0.4	-0.6	0.3
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	0.5	0.5	-0.6	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.1	0.2	0.4	0.4	-0.4	-0.2
Incentive Sensitization - Responses	0.1	0.2	0.3	0.4	0.4	-0.5	0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.3	0.3	-0.5	0.2
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.8	0.4	0.4	-0.5	-0.9
Progressive ratio	0.7	1.2	1.7	-1.3	-1.3	1.0	-0.4
Food seeking constrained by brief footshock	0.6	0.7	1.5	-0.5	-0.5	0.8	-1.2
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	0.6	0.6	-0.5	0.4
Retroperitoneal fat weight	3.8	16.0	19.4	4.4	4.4	-4.3	2.6
Reaction time number correct	2.4	4.6	12.6	0.9	0.9	-2.1	3.5
Reaction time mean minus median	0.2	0.6	1.2	-0.5	-0.5	0.9	-1.1
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.1	-0.1	0.4	-0.4
Reaction time num false alarms	0.1	0.2	0.2	-0.5	-0.5	0.4	-0.2
Reaction time num false alarms AUC	0.3	0.4	0.7	-0.8	-0.8	0.7	-0.0
Reaction time trials correct on left	2.4	4.6	12.6	0.9	0.9	-2.1	3.5
Reaction time trials on left	2.5	4.7	13.0	0.9	0.9	-2.1	3.6
Reaction time mean	0.2	0.4	0.5	0.7	0.7	-0.7	0.4
Reaction time mean AUC	0.4	0.6	0.8	0.7	0.7	-0.8	0.9
Median of all reaction times	0.6	0.8	1.0	0.8	0.8	-1.0	0.8
Reaction time omissions	0.2	0.3	0.5	0.5	0.5	-0.6	0.7
Reaction time false alarm rate	1.5	2.1	3.3	-1.1	-1.1	1.6	-1.8
Reaction time premature initiation rate	1.3	1.9	2.8	-1.7	-1.7	1.2	-0.5
Reaction time premature initiations	0.6	1.0	2.1	-1.0	-1.0	-0.1	1.5
Std. dev. reaction times	0.1	0.3	0.4	-0.6	-0.6	0.5	-0.1
Reaction time trials completed	2.5	4.7	13.0	0.9	0.9	-2.1	3.6
Reaction time trials AUC	2.5	4.9	13.1	0.9	0.9	-2.2	3.6
Run reversals in cocaine runway, females	0.3	0.3	0.7	-0.5	-0.5	0.1	0.8
Run reversals in cocaine runway, males	0.7	0.7	0.8	0.9	0.9	-0.5	-0.9
Latency to leave start box in cocaine runway	0.2	0.2	0.3	-0.6	-0.6	0.4	0.4
Latency to leave start box in cocaine runway, F	0.6	0.7	2.4	-0.3	-0.3	-0.2	1.6
Latency to leave start box in cocaine runway, M	0.3	0.3	0.8	-0.3	-0.3	0.5	-0.9
Std. dev. time between licks in bursts	2.4	3.2	7.6	1.0	1.0	-1.8	2.8
Total sessions with >9 infusions	0.3	0.3	0.5	-0.7	-0.7	0.6	-0.1
Short access day 1 total inactive lever presses	0.2	0.2	0.8	0.0	0.0	-0.3	0.9
Short access day 10 total inactive lever presses	1.6	3.8	5.0	2.1	2.1	-2.2	1.2
Short access day 1 total infusions	1.0	1.4	1.9	-1.4	-1.4	1.3	-0.2
Short access day 10 total infusions	0.5	0.7	1.0	1.0	1.0	-0.8	-0.2
Short access total infusions	0.0	0.0	0.0	-0.2	-0.2	0.1	-0.1
Short access day 1 locomotion	0.4	0.5	0.7	-0.6	-0.6	0.8	-0.8
Short access day 10 total locomotion	0.5	0.9	2.2	-0.5	-0.5	0.9	-1.5
Short access total locomotion	0.4	0.5	1.2	-0.3	-0.3	0.7	-1.1
One hour access (0.3 mA shock)	0.4	0.4	0.5	0.6	0.6	-0.7	0.6
Compulsive drug intake	1.4	1.6	2.1	1.1	1.1	-1.4	1.5
One hour access (shock baseline)	0.0	0.0	0.0	0.1	0.1	-0.0	0.1
Social response proportion	0.2	0.2	0.3	-0.5	-0.5	0.1	0.5
Social responses	0.1	0.1	0.3	-0.1	-0.1	0.1	0.5
Social time	0.0	0.1	0.2	-0.1	-0.1	0.0	0.5
Soleus weight	1.1	3.3	4.8	2.2	2.2	-1.8	0.6
Bone: stiffness	0.6	1.1	1.3	1.1	1.1	-1.1	0.7
Tibialis anterior weight	0.1	0.2	0.6	0.2	0.2	-0.4	0.8
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.4	-0.6	-0.6	0.6	-0.2
Time to tail flick, vehicle, after self-admin	1.5	2.0	2.7	-1.6	-1.6	1.6	-0.2
Time to tail flick, test, before self-admin	0.5	0.5	0.6	-0.8	-0.8	0.6	-0.6
Time to tail flick, test, after self-admin	1.9	1.9	2.1	-1.4	-1.4	1.5	-1.2
Delta time to tail flick, vehicle, before/after SA	0.2	0.1	0.5	-0.1	-0.1	-0.2	0.7
Delta time to tail flick, test, before/after SA	0.7	0.8	1.0	-0.7	-0.7	1.0	-1.0
Tibia length	6.3	17.4	28.1	5.3	5.3	-3.6	-0.7
Ambulatory time before self-admin	1.5	2.3	3.4	1.8	1.8	-1.6	-0.1
Ambulatory time after self-admin	0.8	0.9	1.2	1.0	1.0	-1.1	0.8
Bone: tissue strength	2.6	2.6	3.1	1.8	1.8	-1.7	1.2
Total heroin consumption	0.2	0.3	1.1	0.0	0.0	0.2	-1.0
Bone: trabecular number	0.0	0.0	0.0	0.1	0.1	0.0	-0.1
Bone: trabecular spacing	2.1	2.8	6.9	0.8	0.8	-1.8	2.6
Bone: trabecular thickness	0.7	0.9	3.1	0.5	0.5	0.3	-1.8
Bone: trabecular tissue density	0.7	1.0	1.5	-1.2	-1.2	1.0	-0.1
Water consumed over 24 hours	0.5	0.6	1.6	-0.3	-0.3	0.9	-1.2
Number of responses in last shaping day	0.0	0.0	0.0	-0.2	-0.2	0.1	0.0