Hub : Genes

Anapc10

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr19_45058702_45103979 0.02 0.01 2.6e-04 0.01 0.02 0.02 0.02 7.0e-03 5.3e-04 1.4e-03 1.3e-03
2 NAcc gene expression Anapc10 0.02 0.01 2.4e-04 0 0.01 0.01 0 8.1e-02 2.6e-03 2.0e-02 4.8e-02
3 NAcc intron excision ratio chr19_45058702_45095169 0.03 0.02 5.7e-03 0 0 0 0.01 1.1e-01 9.7e-02 1.2e-01 3.6e-03
4 NAcc isoform ratio NM_001108445.1 0.04 0.02 5.9e-05 0.02 0.02 0.03 0.02 1.8e-04 3.2e-04 6.4e-05 1.2e-04
5 NAcc isoform ratio XM_063278119.1 0.04 0.02 3.8e-05 0.02 0.02 0.02 0.03 1.2e-04 1.2e-04 3.2e-04 5.1e-05
6 Brain alternative polyA XM_008772516.4 0.06 0.03 7.8e-05 0.03 0.02 0.02 0.02 1.8e-03 4.4e-03 4.6e-03 2.6e-03
7 Brain alternative polyA XM_008772516.4 0.07 0.04 1.5e-04 0.04 0.04 0.03 0.04 1.3e-04 1.4e-04 6.3e-04 2.3e-04
8 pVTA gene expression Anapc10 0.06 0.03 2.1e-05 0.07 0.04 0.05 0.04 2.2e-06 2.5e-04 7.6e-05 5.9e-04
9 PL gene expression Anapc10 0.05 0.03 2.8e-04 0.03 0.02 0.02 0.02 8.6e-04 3.0e-03 4.5e-03 4.8e-03
10 Brain isoform ratio XM_063278119.1 0.06 0.04 7.2e-05 0.03 0.05 0.07 0.05 1.6e-03 3.9e-05 6.8e-07 3.4e-05
11 Brain isoform ratio NM_001108445.1 0.05 0.03 4.0e-04 0.03 0.03 0.05 0.04 1.1e-03 3.4e-04 2.2e-05 1.4e-04
12 Brain gene expression Anapc10 0.08 0.05 2.2e-05 0.04 0.05 0.04 0.05 5.1e-05 9.2e-06 5.5e-05 4.2e-05
13 Brain alternative polyA XM_063278119.1 0.04 0.02 6.3e-04 0.02 0.02 0.01 0.02 5.5e-03 5.2e-03 2.7e-02 5.2e-03
14 BLA gene expression Anapc10 0.06 0.04 5.0e-03 0.03 0.03 0.03 0.04 1.3e-02 6.5e-03 7.6e-03 5.4e-03
15 Brain alternative polyA NM_001108445.1 0.06 0.04 1.8e-04 0.03 0.04 0.03 0.04 4.1e-04 2.3e-04 8.1e-04 3.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.42.43.4-1.4-1.41.71.7-1.71.71.7-1.5-1.5-1.31.3-1.6-1.8-1.5-1.3
Area under the delay curve0.10.10.4-0.2-0.20.1-0.1-0.10.60.6-0.1-0.40.3-0.3-0.10.50.5-0.4
BMI with tail1.55.310.82.52.4-3.3-3.02.3-1.1-1.11.31.42.9-3.02.02.82.40.8
BMI without tail0.61.84.1-0.8-0.80.41.0-1.42.02.0-1.4-1.9-0.30.3-1.8-0.7-0.8-2.0
Body weight0.73.25.5-2.0-1.91.41.9-2.22.22.2-2.4-2.1-0.90.9-1.7-0.7-1.1-1.9
Weight adjusted by age0.10.10.4-0.1-0.2-0.3-0.30.30.00.00.70.1-0.40.40.4-0.00.20.1
Bone surface1.42.64.1-1.5-1.51.61.7-1.71.51.5-1.7-1.5-1.61.6-1.6-2.0-1.7-1.3
Bone volume3.25.77.6-2.4-2.42.52.6-2.62.42.4-2.2-2.3-2.32.3-2.3-2.7-2.4-1.9
Breakpoint value in progressive ratio session1.72.14.51.71.8-1.3-1.21.5-1.6-1.61.42.11.0-1.01.20.90.81.8
Number of licking bursts0.71.11.7-0.9-0.91.10.9-1.01.31.3-1.3-1.3-0.80.7-1.2-1.1-0.6-1.3
Context. condit. distance diff. score0.10.10.5-0.7-0.70.20.1-0.00.00.0-0.20.2-0.40.40.40.1-0.30.1
Locomotion velocity, session 10.20.20.60.20.3-0.5-0.40.6-0.6-0.60.30.8-0.10.10.70.2-0.30.6
Locomotion distance, session 10.50.61.00.80.8-0.9-0.80.9-1.0-1.00.61.00.3-0.20.90.70.10.8
Locomotion velocity, session 20.20.20.6-0.4-0.30.20.3-0.40.20.2-0.8-0.5-0.70.7-0.3-0.3-0.7-0.4
Locomotion distance, session 20.00.00.10.20.2-0.2-0.20.3-0.2-0.20.00.3-0.00.10.30.1-0.10.3
Locomotion velocity, session 30.30.31.1-0.5-0.50.40.3-0.20.30.3-0.5-0.3-1.11.1-0.4-0.8-0.8-0.5
Locomotion distance, session 31.41.62.6-0.7-0.60.50.7-1.01.31.3-1.6-1.3-1.41.4-1.4-1.5-1.5-1.5
Stereotopy head waving bouts, day 30.20.20.7-0.1-0.20.2-0.1-0.10.80.8-0.2-0.7-0.30.3-0.4-0.1-0.1-0.9
Stereotopy head waving duration, day 30.10.10.60.20.2-0.2-0.80.60.00.00.40.00.1-0.10.50.40.3-0.2
Locomotion velocity, session 70.40.40.8-0.4-0.40.30.5-0.50.50.5-0.6-0.6-0.90.9-0.6-0.7-0.8-0.7
Locomotion distance, session 70.20.30.4-0.5-0.50.40.6-0.50.60.6-0.3-0.4-0.60.6-0.5-0.5-0.6-0.3
Stereotopy head waving bouts, day 70.50.62.30.80.8-0.30.1-0.50.90.9-0.6-0.80.2-0.3-1.5-0.7-0.1-1.2
Stereotopy head waving duration, day 70.50.62.30.40.3-0.00.3-0.61.11.1-0.7-0.9-0.10.1-1.5-0.9-0.4-1.3
Locomotion velocity, session 81.01.22.50.60.6-0.6-0.71.1-1.4-1.41.01.50.6-0.61.51.00.81.6
Locomotion distance, session 80.20.30.80.00.0-0.5-0.50.7-0.5-0.50.30.90.0-0.00.90.4-0.00.7
Degree of sensitization distance0.20.20.7-0.4-0.40.30.30.1-0.3-0.30.80.40.3-0.30.60.30.40.8
Degree of sensitization stereotypy0.50.52.30.50.5-0.10.4-0.70.80.8-0.8-0.70.0-0.1-1.5-0.9-0.3-1.1
Conditioned locomotion0.30.31.1-0.9-0.91.00.8-0.50.20.2-0.0-0.4-0.40.4-0.2-0.4-0.20.0
Cocaine response after cond. corrected0.91.12.9-1.7-1.71.31.0-0.70.80.8-0.4-0.3-1.41.4-0.1-1.1-1.0-0.2
Cocaine response after cond. not corrected0.40.51.5-1.2-1.20.90.6-0.30.10.1-0.20.1-1.01.00.3-0.6-0.80.2
Cocaine response before conditioning0.80.91.91.31.4-1.1-1.00.8-1.1-1.10.30.71.0-1.10.51.00.70.6
Saline control response1.72.23.9-1.8-1.81.71.6-1.20.70.7-1.3-1.1-2.02.0-1.3-1.5-2.0-1.1
Bone: connectivity density0.40.61.5-0.4-0.40.70.6-0.70.90.9-0.7-0.8-0.70.7-0.9-1.2-0.9-0.8
Bone: cortical apparent density0.20.20.50.60.6-0.7-0.60.50.30.30.60.10.5-0.60.20.30.40.0
Bone: cortical area0.30.51.4-1.2-1.11.11.0-0.6-0.1-0.10.1-0.1-0.80.80.2-0.3-0.60.4
Bone: cortical porosity0.10.10.4-0.2-0.20.50.3-0.1-0.6-0.6-0.10.2-0.30.30.1-0.1-0.30.3
Bone: cortical porosity0.30.31.2-0.7-0.61.10.9-0.6-0.3-0.3-0.5-0.2-0.60.6-0.4-0.5-0.50.0
Bone: cortical thickness1.01.62.50.90.9-0.7-0.91.2-1.4-1.41.61.21.2-1.21.61.51.41.6
Bone: cortical thickness0.60.71.00.70.8-0.9-0.90.9-0.6-0.60.80.70.8-0.80.91.00.80.8
Bone: cortical tissue density0.10.10.30.40.4-0.5-0.40.30.40.40.4-0.10.3-0.3-0.00.10.2-0.2
Condit. Reinf. active minus inactive responses0.10.10.20.50.50.20.4-0.3-0.4-0.40.2-0.00.3-0.3-0.30.10.40.3
Condit. Reinf. active-inactive response ratio0.20.20.60.40.40.00.00.2-0.6-0.60.70.60.5-0.50.30.40.40.8
Condit. Reinf. active responses0.40.51.4-0.2-0.10.71.0-1.20.40.4-0.8-0.9-0.40.4-1.1-0.7-0.4-0.6
Condit. Reinf. inactive responses1.82.23.5-1.0-0.91.31.7-1.91.61.6-1.5-1.7-1.11.1-1.9-1.8-1.2-1.4
Incentive salience index mean0.10.20.70.30.40.40.7-0.70.10.1-0.3-0.40.1-0.1-0.8-0.3-0.2-0.2
Condit. Reinf. lever presses0.40.51.80.30.30.30.7-0.90.80.8-1.0-0.80.1-0.1-1.3-0.5-0.6-0.9
Condit. Reinf. active minus inactive responses0.10.20.5-0.6-0.50.70.2-0.1-0.6-0.6-0.10.2-0.70.60.30.2-0.00.2
Condit. Reinf. active-inactive response ratio0.50.61.6-1.3-1.31.20.9-0.70.30.3-0.6-0.2-1.11.1-0.1-0.6-0.3-0.2
Condit. Reinf. active responses0.10.20.6-0.00.10.3-0.10.2-0.8-0.80.20.30.0-0.10.40.70.50.4
Condit. Reinf. inactive responses0.50.61.30.60.7-0.3-0.50.6-1.1-1.10.70.50.7-0.70.71.10.60.8
Condit. Reinf. lever presses1.92.63.71.81.9-1.8-1.91.6-1.5-1.50.91.21.8-1.81.41.91.81.1
Condit. Reinf. lever reinforcers received0.30.51.30.40.5-0.1-0.50.6-1.1-1.10.40.60.4-0.50.71.10.90.6
Conditioned reinforcement - actives0.61.01.9-1.4-1.30.80.9-1.01.11.1-1.4-0.8-0.90.8-0.8-0.5-0.6-1.1
Conditioned reinforcement - inactives0.40.51.2-0.6-0.60.10.3-0.60.70.7-1.1-0.8-0.90.9-0.7-0.7-0.4-1.0
Conditioned locomotion0.40.50.6-0.8-0.70.80.8-0.70.70.7-0.6-0.6-0.70.7-0.7-0.6-0.4-0.6
Patch foraging indifference point 0 sec0.30.61.8-0.4-0.30.40.6-0.81.11.1-1.1-1.30.1-0.2-1.00.1-0.4-1.0
Patch foraging indifference point AUC0.10.11.00.10.1-0.3-0.0-0.0-0.3-0.3-0.1-0.2-0.40.4-0.2-0.6-1.0-0.2
Delay disc. indifference point, 0s delay0.30.40.90.50.4-0.8-0.90.9-0.7-0.70.60.80.00.00.70.4-0.10.4
Delay disc. indifference point, 16s delay0.91.02.50.60.6-0.8-0.80.8-0.4-0.41.20.71.3-1.31.01.51.60.9
Delay disc. indifference point, 2s delay0.00.10.20.10.0-0.3-0.40.20.20.2-0.3-0.1-0.00.1-0.00.20.3-0.4
Delay disc. indifference point, 24s delay0.20.20.4-0.4-0.50.60.3-0.30.60.60.3-0.50.1-0.2-0.10.40.6-0.2
Delay disc. indifference point, 4s delay0.80.81.5-1.2-1.21.00.6-0.71.01.0-1.1-0.9-0.90.9-0.6-0.5-0.6-1.0
Delay disc. indifference point, 8s delay0.20.20.7-0.3-0.40.40.1-0.30.80.8-0.3-0.90.1-0.2-0.30.30.4-0.6
Indifference point function ln k0.20.31.2-0.5-0.40.20.3-0.51.11.1-1.1-0.50.2-0.3-0.30.10.2-0.6
Indifference point function log k0.20.31.2-0.5-0.40.20.3-0.51.11.1-1.1-0.50.2-0.3-0.30.10.2-0.6
Patch foraging total patch changes 0 sec0.40.72.1-0.6-0.50.60.7-0.91.11.1-1.1-1.50.1-0.2-1.10.1-0.3-1.0
Patch foraging total patch changes 12 sec0.10.10.50.40.4-0.30.1-0.20.10.1-0.0-0.5-0.00.1-0.7-0.0-0.5-0.4
Patch foraging total patch changes 18 sec0.81.33.5-0.6-0.60.80.9-0.90.90.9-1.0-1.2-1.11.1-1.7-1.5-1.9-1.3
Patch foraging total patch changes 24 sec0.61.02.1-0.5-0.51.01.1-1.20.90.9-0.9-1.4-0.70.7-1.4-0.9-1.1-1.0
Patch foraging total patch changes 6 sec0.10.10.4-0.00.0-0.10.1-0.30.40.4-0.6-0.60.2-0.2-0.40.3-0.1-0.4
Patch foraging time to switch 0 sec0.20.31.00.60.6-0.2-0.50.7-0.8-0.80.71.0-0.10.10.50.30.40.7
Patch foraging water rate 0 sec0.10.20.6-0.6-0.50.50.8-0.70.60.6-0.3-0.70.2-0.2-0.30.1-0.3-0.1
Patch foraging water rate 12 sec0.10.20.60.10.1-0.6-0.50.10.70.7-0.20.00.7-0.80.20.50.7-0.4
Patch foraging water rate 18 sec0.60.92.4-0.6-0.60.90.9-1.21.61.6-0.9-1.20.2-0.3-1.0-0.30.2-1.1
Patch foraging water rate 24 sec0.10.10.40.10.0-0.3-0.40.30.40.40.4-0.30.6-0.60.20.10.7-0.1
Patch foraging water rate 6 sec0.10.10.40.50.5-0.00.3-0.10.10.10.50.20.6-0.6-0.10.30.10.5
Seeking ratio, delayed vs. immediate footshock0.10.10.4-0.3-0.3-0.00.0-0.20.50.5-0.60.10.4-0.4-0.00.20.0-0.4
Distance traveled before self-admin0.20.31.00.70.6-1.0-0.90.7-0.2-0.20.10.50.1-0.10.50.00.10.1
Distance traveled after self-admin0.30.30.6-0.4-0.40.20.5-0.60.80.8-0.7-0.1-0.70.7-0.6-0.5-0.4-0.7
Extensor digitorum longus weight1.04.17.62.82.7-2.4-2.22.1-1.5-1.51.81.72.3-2.31.41.61.71.7
Bone: elastic displacement0.00.00.2-0.1-0.10.10.1-0.20.10.1-0.1-0.3-0.10.1-0.4-0.30.0-0.3
Bone: elastic work0.10.10.60.10.10.1-0.10.0-0.3-0.30.50.20.5-0.50.30.40.80.4
Bone: endosteal estimation1.02.13.8-1.6-1.61.31.7-1.61.11.1-1.5-0.9-1.71.8-1.2-1.6-1.9-0.8
Bone: endosteal perimeter2.65.69.7-3.1-3.12.92.8-2.41.11.1-1.8-1.3-3.03.1-1.3-2.4-2.8-0.9
Epididymis fat weight3.210.913.7-3.3-3.23.13.3-3.53.73.7-3.7-3.6-2.92.9-3.4-2.8-2.7-3.4
Delta time in closed arm before/after self-admin0.30.20.7-0.2-0.20.70.8-0.70.20.20.1-0.4-0.10.0-0.8-0.7-0.6-0.4
Delta time in open arm before/after self-admin0.40.41.2-0.00.1-0.2-0.20.5-0.5-0.50.30.40.5-0.51.01.11.11.1
Diff in mean of infusions in LGA sessions1.11.32.11.01.0-1.2-1.21.4-1.4-1.41.11.40.5-0.41.40.70.61.5
Delay discount exponential model param0.20.20.60.40.5-0.3-0.10.3-0.8-0.80.40.6-0.00.10.2-0.3-0.40.6
Extinction: sum of active levers before priming1.21.34.51.81.8-2.1-1.71.00.00.0-0.40.51.1-1.10.31.00.9-0.4
Active lever presses in extinction session 62.92.97.31.71.6-2.7-2.72.0-0.7-0.70.50.71.8-1.81.82.21.80.5
Bone: final force0.10.20.80.10.2-0.10.10.2-0.4-0.40.60.50.3-0.30.60.40.30.9
Bone: final moment0.10.10.5-0.00.1-0.00.20.0-0.3-0.30.50.40.3-0.30.40.30.10.7
Food consumed during 24 hour testing period0.40.61.7-0.4-0.30.51.1-0.80.20.2-0.4-0.5-0.91.0-1.0-1.0-1.3-0.2
Glucose0.20.41.50.30.3-0.2-0.00.5-0.6-0.61.01.20.2-0.10.60.40.11.2
Heart weight0.20.30.80.50.5-0.7-0.60.00.70.7-0.9-0.10.3-0.3-0.10.40.3-0.8
Delay discount hyperbolic model param0.10.20.50.30.3-0.2-0.00.2-0.7-0.70.40.6-0.10.10.2-0.3-0.40.5
Intermittent access intake day 1-15 change0.71.32.6-0.8-0.80.91.1-1.31.61.6-1.2-1.6-0.90.9-1.3-0.9-0.2-1.3
Intermittent access intake escalation0.20.51.3-0.3-0.30.50.6-0.71.11.1-0.6-1.0-0.50.5-0.8-0.50.2-0.7
Intermittent access intake escalation 20.70.81.2-0.6-0.60.60.8-0.91.11.1-0.5-1.1-1.01.1-1.1-1.1-0.6-0.9
Intermitt. access day 1 inactive lever presses0.72.53.9-1.9-1.91.21.3-1.62.02.0-1.8-1.4-1.21.2-1.3-1.1-1.7-1.8
Intermitt. access day 15 inactive lever presses0.00.00.10.1-0.0-0.2-0.20.10.10.10.2-0.30.0-0.00.40.10.10.1
Intermitt. access escalation Index1.11.62.5-1.2-1.21.11.1-1.31.21.2-1.6-1.5-1.11.0-1.3-1.2-1.4-1.6
Intermittent access day 1 total infusions0.10.10.4-0.7-0.60.2-0.1-0.00.30.3-0.4-0.1-0.40.40.0-0.20.1-0.4
Intermittent access day 15 total infusions0.50.71.6-0.7-0.70.40.3-0.61.21.2-1.0-1.0-0.80.8-0.7-0.50.1-1.3
Intermittent access terminal intake (last 3 days)1.41.93.0-1.5-1.51.10.9-1.31.71.7-1.4-1.5-1.41.4-1.3-1.2-0.6-1.7
Intermittent access total infusions0.70.91.5-1.2-1.20.70.6-0.81.11.1-1.1-0.8-1.01.0-0.7-0.7-0.3-1.2
Intermittent access day 1 locomotion0.10.10.40.10.1-0.5-0.60.4-0.1-0.1-0.10.30.4-0.40.40.30.3-0.1
Intermittent access day 15 total locomotion0.91.62.7-1.3-1.20.80.9-1.21.41.4-1.6-1.1-1.41.3-1.3-1.2-0.9-1.6
Intermittent access total locomotion0.10.10.1-0.3-0.2-0.3-0.30.20.20.2-0.40.4-0.30.20.2-0.10.1-0.2
Intermittent access standard deviation2.65.48.2-2.1-2.22.11.9-2.22.72.7-2.0-2.9-2.42.4-2.4-2.3-1.5-2.5
Left kidney weight0.20.71.6-0.6-0.50.40.9-1.00.90.9-1.2-1.0-0.60.5-1.0-0.8-1.0-0.9
Right kidney weight0.10.41.4-0.4-0.30.61.2-1.10.50.5-0.7-0.7-0.30.3-1.0-0.4-0.8-0.3
Cocaine induced anxiety0.10.10.50.40.3-0.4-0.30.3-0.5-0.50.70.1-0.00.10.5-0.00.20.5
Post-drug Anxiety0.10.10.40.30.2-0.10.2-0.1-0.6-0.60.6-0.00.00.00.10.10.10.4
Baseline Anxiety0.40.51.6-0.6-0.60.50.7-0.90.70.7-1.3-0.9-0.20.2-0.90.0-0.5-0.9
Tail length6.625.834.2-5.4-5.25.25.9-5.85.05.0-5.0-5.2-4.64.6-5.3-4.7-4.4-4.4
Length with tail5.122.330.4-5.4-5.25.05.5-5.54.44.4-4.9-4.6-4.44.4-4.6-4.2-4.2-3.9
Length without tail0.41.22.8-1.7-1.51.11.2-1.20.60.6-1.6-0.9-1.11.1-0.4-0.4-1.0-0.6
Times rat made contact with spout0.20.31.10.80.7-1.1-0.80.5-0.2-0.2-0.20.3-0.10.1-0.1-0.2-0.7-0.4
Lifetime Intake0.91.12.0-1.4-1.30.90.6-0.91.31.3-1.2-1.0-1.11.0-0.8-0.7-0.5-1.4
Liver weight, left0.91.52.0-1.3-1.31.11.4-1.31.31.3-1.4-1.0-1.11.1-1.2-1.2-1.3-1.0
Liver weight, right0.30.41.1-1.0-1.00.60.7-0.60.70.7-0.5-0.9-0.30.3-0.6-0.1-0.6-0.5
Locomotor activity0.81.32.81.01.0-1.7-1.61.3-0.9-0.90.40.81.0-1.01.41.50.60.8
Locomotor testing distance0.30.51.40.70.7-1.2-1.10.8-0.5-0.50.10.40.5-0.50.70.90.00.2
Locomotor testing rearing1.22.43.61.71.8-1.9-1.81.8-1.8-1.81.21.71.2-1.11.61.40.71.4
Locomotion in novel chamber1.41.72.71.11.1-1.4-1.11.1-1.2-1.21.21.61.6-1.61.51.31.01.5
Locomotion in novel chamber post-restriction0.20.31.00.20.1-0.7-0.40.4-0.8-0.80.31.00.1-0.10.5-0.2-1.00.3
Fecal boli incidents, locomotor time 10.20.30.8-0.2-0.1-0.10.3-0.40.00.0-0.8-0.7-0.70.8-0.6-0.4-0.9-0.6
Change in fecal boli incidents, locomotor task0.60.61.0-0.8-0.91.00.6-0.61.01.0-0.6-0.9-0.50.4-0.6-0.8-0.6-0.6
Time >=10cm from walls, locomotor time 12.83.05.3-1.2-1.21.91.9-2.01.91.9-1.6-1.9-1.31.2-2.3-2.0-1.4-1.8
Bouts of movement, locomotor time 11.71.92.91.21.1-1.5-1.31.2-1.4-1.41.60.91.4-1.41.51.71.61.1
Total resting periods, locomotor time 11.61.83.41.21.1-1.5-1.11.0-1.0-1.01.50.51.7-1.71.31.81.81.0
Rest time, locomotor task time 11.41.86.2-1.1-1.11.31.5-1.71.31.3-1.3-2.5-0.80.8-1.5-0.6-0.8-1.5
Distance moved, locomotor task time 10.91.34.51.01.0-0.7-1.01.3-1.3-1.31.02.10.8-0.81.10.70.51.5
Vertical activity count, locomotor time 10.20.41.2-0.5-0.50.70.8-0.1-0.2-0.20.50.5-0.70.8-0.4-1.0-1.10.6
Time >=10cm from walls, locomotor time 20.30.51.6-0.1-0.00.50.40.0-1.0-1.01.30.80.4-0.40.60.50.91.1
Bouts of movement, locomotor time 20.50.93.30.70.7-0.8-0.80.30.00.00.3-0.11.4-1.50.71.81.60.1
Total resting periods, locomotor time 20.30.62.10.50.5-0.5-0.5-0.00.40.4-0.0-0.71.1-1.20.31.51.4-0.2
Rest time, locomotor task time 21.11.44.5-0.8-0.80.61.0-1.21.41.4-1.6-2.1-0.70.7-1.3-0.8-0.7-1.4
Distance moved, locomotor task time 21.51.85.10.90.9-0.4-0.81.3-1.8-1.81.82.30.7-0.71.51.01.01.8
Vertical activity count, locomotor time 20.60.82.2-0.3-0.20.80.60.3-1.3-1.31.21.3-0.80.80.5-0.3-0.81.5
Light reinforcement 10.20.41.80.80.8-0.30.8-0.4-0.2-0.20.2-0.0-0.10.2-1.1-1.1-1.30.3
Light reinforcement 20.20.31.40.50.60.41.2-0.6-0.3-0.30.2-0.20.3-0.3-1.0-0.7-0.60.5
Bone: marrow area0.92.03.5-1.5-1.51.31.6-1.51.01.0-1.4-0.8-1.71.7-1.1-1.6-1.9-0.7
Bone: maximum diameter1.42.65.1-2.2-2.32.11.9-1.61.11.1-1.1-1.1-1.91.9-0.8-1.6-1.7-0.7
Bone: maximum force0.10.10.4-0.6-0.50.40.5-0.2-0.1-0.10.10.1-0.10.10.40.10.00.6
Bone: maximum moment0.10.10.4-0.7-0.60.50.7-0.40.10.1-0.1-0.0-0.20.20.2-0.0-0.10.4
Mean time between licks in bursts0.10.20.6-0.2-0.10.40.5-0.60.40.4-0.8-0.3-0.20.2-0.6-0.5-0.3-0.3
Mean num. licks in bursts0.60.92.51.11.1-1.6-1.11.0-0.9-0.90.91.10.5-0.40.80.7-0.00.6
Cd content in liver0.10.10.40.30.4-0.1-0.30.2-0.7-0.70.00.40.3-0.30.40.6-0.00.3
Co content in liver0.40.52.10.90.9-0.40.1-0.20.10.1-0.1-0.31.4-1.4-0.70.20.8-0.1
Cu content in liver1.11.31.71.21.2-0.8-1.01.1-1.3-1.31.11.21.3-1.31.11.21.01.3
Fe content in liver0.40.51.1-0.7-0.70.90.8-0.80.90.90.0-1.0-0.40.3-0.8-0.4-0.1-0.7
K content in liver0.90.82.1-1.3-1.30.80.5-0.60.40.4-0.9-0.6-1.41.4-0.3-0.7-1.0-0.8
Mg content in liver0.40.41.3-1.1-1.11.00.6-0.40.60.6-0.6-0.2-0.80.8-0.0-0.2-0.4-0.2
Mn content in liver1.11.22.4-1.5-1.51.41.1-0.80.90.9-0.7-0.6-1.51.6-0.6-0.9-1.0-0.6
Na content in liver0.20.30.8-0.7-0.60.60.4-0.30.00.0-0.5-0.4-0.70.7-0.1-0.2-0.9-0.3
Rb content in liver0.30.30.80.70.6-0.3-0.50.6-0.5-0.50.90.50.5-0.50.50.50.50.6
Se content in liver0.60.72.50.10.10.2-0.10.6-0.8-0.81.41.10.5-0.41.20.81.11.6
Sr content in liver0.40.31.4-0.7-0.60.30.3-0.50.30.3-1.2-0.6-0.50.5-0.4-0.5-0.5-0.6
Zn content in liver0.10.10.2-0.2-0.20.40.4-0.3-0.0-0.0-0.50.1-0.10.1-0.3-0.1-0.00.0
Bone: minimum diameter1.52.74.9-2.1-2.12.02.2-1.91.11.1-1.2-1.1-1.91.9-1.2-1.7-1.8-0.6
Time in familiar zone, hab. session 10.60.62.01.41.4-0.9-0.40.5-0.5-0.51.10.70.8-0.70.10.30.50.7
Time in novel zone, hab. session 10.30.31.1-0.8-0.80.1-0.4-0.00.60.6-1.1-0.7-0.30.20.0-0.10.0-1.0
Total zone transitions, hab. session 10.10.20.50.50.5-0.7-0.50.4-0.6-0.60.10.5-0.00.10.40.40.00.2
Total locomotion distance, hab. session 10.00.00.2-0.0-0.0-0.10.1-0.0-0.1-0.1-0.00.1-0.40.4-0.1-0.0-0.10.0
Locomotion velocity, hab. session 10.10.10.3-0.2-0.10.20.4-0.30.00.0-0.20.1-0.50.5-0.4-0.2-0.4-0.0
Time in familiar zone, hab. session 20.10.10.20.20.20.10.4-0.20.20.20.4-0.00.3-0.3-0.4-0.20.10.2
Time in novel zone, hab. session 20.20.20.50.30.3-0.4-0.50.5-0.5-0.50.00.40.3-0.30.70.70.70.4
Total zone transitions, hab. session 20.10.10.20.40.4-0.4-0.30.3-0.5-0.5-0.20.4-0.20.20.20.1-0.40.1
Total locomotion distance, hab. session 20.20.20.70.10.20.00.20.2-0.8-0.80.40.7-0.30.30.30.2-0.10.8
Locomotion velocity, hab. session 20.10.20.60.20.3-0.10.10.2-0.7-0.70.40.7-0.20.20.30.2-0.20.8
Novel to familiar place preference ratio0.20.30.90.40.3-0.7-0.90.9-0.3-0.30.50.60.2-0.20.60.40.30.2
Novelty place preference0.40.40.90.60.5-0.8-0.90.9-0.5-0.50.60.70.4-0.40.70.60.40.5
Time in novel zone, NPP test0.20.30.70.50.5-0.8-0.80.8-0.3-0.30.30.50.4-0.40.50.50.40.2
Total zone transitions, NPP test0.50.81.9-0.6-0.50.70.8-0.80.40.4-1.2-0.5-1.21.2-0.9-1.0-1.4-0.7
Total locomotion distance, NPP test1.52.13.6-1.4-1.41.21.3-1.41.01.0-1.7-1.2-1.91.9-1.3-1.4-1.6-1.4
Locomotion velocity, NPP test1.62.34.3-1.6-1.51.41.4-1.50.90.9-1.6-1.2-2.12.1-1.2-1.5-1.8-1.2
Intraocular pressure0.10.20.40.50.5-0.6-0.60.10.30.3-0.2-0.50.4-0.3-0.1-0.20.2-0.4
Delta distance traveled before/after self-admin0.10.10.2-0.5-0.50.30.3-0.20.20.2-0.40.3-0.40.4-0.20.1-0.2-0.1
Delta ambulatory time before/after self-admin0.40.51.0-0.7-0.70.71.0-0.80.60.6-1.0-0.1-0.70.8-0.9-0.3-0.7-0.5
Parametrial fat weight0.71.73.0-1.7-1.61.31.5-1.41.11.1-1.6-1.1-1.21.2-0.9-0.9-1.5-0.9
Pavlov. Cond. lever latency0.10.10.50.20.2-0.3-0.60.7-0.2-0.20.60.4-0.10.10.4-0.20.20.2
Pavlov. Cond. magazine entry latency1.11.42.01.41.4-1.4-1.10.9-1.4-1.40.80.91.3-1.31.01.21.10.9
Pavlov. Cond. change in total contacts0.20.20.40.50.5-0.30.0-0.0-0.5-0.50.20.40.6-0.60.20.30.40.5
Pavlov. Cond. index score0.20.30.70.50.6-0.7-0.40.1-0.8-0.8-0.10.30.6-0.60.50.90.40.4
Pavlov. Cond. latency score0.20.30.60.50.5-0.5-0.30.1-0.7-0.7-0.10.30.6-0.60.40.80.40.4
Pavlov. Cond. lever contacts0.10.10.30.10.2-0.10.1-0.3-0.3-0.3-0.2-0.10.4-0.40.00.50.20.1
Pavlov. Cond. magazine entry number0.81.01.8-1.1-1.21.10.9-0.71.31.3-0.4-0.7-1.01.0-0.8-1.1-0.8-0.8
Pavlov. Cond. intertrial magazine entries0.91.13.4-1.2-1.21.81.7-1.30.70.70.2-0.8-0.80.8-1.0-1.1-0.3-0.3
Pavlov. Cond. lever-magazine prob. diff.0.40.51.10.60.6-0.8-0.50.3-1.0-1.00.10.60.7-0.70.81.00.60.7
Pavlov. Cond. response bias0.40.51.01.01.0-0.8-0.50.2-0.8-0.80.10.30.9-0.90.20.80.60.3
Pavlov. Cond. lever latency1.31.84.6-2.0-2.11.81.3-1.11.11.1-0.5-0.8-1.61.6-0.6-1.2-1.2-0.7
Pavlov. Cond. magazine entry latency0.81.02.51.41.6-0.9-0.50.6-1.2-1.20.80.51.2-1.20.20.80.50.9
Pavlov. Cond. change in total contacts1.11.84.32.02.1-1.8-1.61.3-1.2-1.20.80.91.4-1.40.81.21.20.6
Pavlov. Cond. index score1.92.56.02.32.4-1.9-1.51.3-1.5-1.51.01.01.8-1.80.81.51.21.0
Pavlov. Cond. latency score1.62.15.32.12.3-1.8-1.31.2-1.5-1.50.90.91.6-1.70.61.41.01.0
Pavlov. Cond. lever contacts1.41.95.02.12.2-1.8-1.41.1-1.1-1.10.60.81.7-1.70.51.21.20.7
Pavlov. Cond. magazine entry number1.51.84.3-1.9-2.11.31.0-1.01.51.5-1.0-0.9-1.61.6-0.6-1.2-1.0-1.2
Pavlov. Cond. intertrial magazine entries0.30.40.7-0.8-0.70.60.6-0.60.40.4-0.4-0.6-0.90.8-0.4-0.5-0.8-0.5
Pavlov. Cond. lever-magazine prob. diff.1.72.25.62.22.4-1.8-1.31.2-1.5-1.50.91.01.7-1.70.61.41.11.0
Pavlov. Cond. response bias1.41.94.52.02.1-1.5-1.21.1-1.2-1.20.80.81.7-1.80.61.41.31.0
Time in closed arm before self-admin1.51.93.8-0.9-1.00.80.5-0.81.41.4-1.5-1.1-1.91.9-1.3-1.7-1.4-1.7
Time in closed arm after self-admin1.21.33.5-0.3-0.41.20.9-1.00.90.9-0.4-0.8-1.41.4-1.5-1.9-1.5-1.2
Time in open arm before self-admin0.70.71.30.80.8-0.7-0.60.7-0.9-0.90.60.91.1-1.10.71.10.60.9
Time in open arm after self-admin1.92.04.50.91.0-1.5-1.31.4-1.2-1.20.60.81.6-1.61.92.11.91.6
Bone: periosteal estimation1.02.13.5-1.9-1.81.61.9-1.61.01.0-1.1-0.9-1.71.8-0.9-1.5-1.8-0.5
Bone: periosteal perimeter1.52.75.1-2.3-2.22.21.9-1.50.70.7-1.1-0.8-2.12.1-0.8-1.8-1.9-0.6
Bone: post-yield work0.71.01.5-1.0-1.00.91.2-1.11.11.1-0.9-0.9-0.80.8-0.9-1.1-1.0-0.6
Progressive ratio test 1 active lever presses0.10.20.8-0.9-0.90.2-0.1-0.00.10.1-0.50.1-0.20.10.20.40.2-0.4
Progressive ratio test 1 breakpoint0.10.10.8-0.9-0.90.2-0.10.00.10.1-0.40.1-0.10.10.20.40.3-0.4
Progressive ratio test 1 inactive lever presses0.91.23.5-1.9-1.91.31.2-1.11.01.0-1.0-1.0-0.80.7-0.6-0.5-0.9-0.8
Progressive ratio test 2 active lever presses0.30.40.9-0.8-0.80.10.1-0.30.60.6-0.7-0.1-0.70.7-0.4-0.7-0.6-0.9
Progressive ratio test 2 breakpoint0.30.30.8-0.7-0.80.10.0-0.20.60.6-0.7-0.0-0.70.6-0.3-0.6-0.6-0.9
Progressive ratio test 2 inactive lever presses0.20.30.7-0.7-0.70.30.5-0.50.70.7-0.3-0.3-0.70.7-0.4-0.8-0.6-0.5
Incentive Sensitization - Responses0.10.20.70.30.2-0.8-0.50.4-0.2-0.20.40.7-0.30.40.1-0.8-0.4-0.1
Incentive Sensitization - Breakpoint0.10.20.90.30.1-0.6-0.40.3-0.1-0.10.30.6-0.40.4-0.1-0.9-0.5-0.2
Sum of active levers in priming session hrs 5-66.45.99.83.13.1-2.7-2.32.4-2.2-2.22.32.52.3-2.21.92.22.32.3
Progressive ratio0.50.81.91.11.1-1.4-1.01.1-1.0-1.00.51.00.4-0.40.60.10.40.8
Food seeking constrained by brief footshock1.31.64.4-1.5-1.51.01.2-1.41.41.4-2.1-1.3-0.80.7-0.9-0.8-0.8-1.3
Seeking ratio, punishment vs. effort1.01.52.8-1.6-1.61.71.5-1.51.51.5-1.0-1.4-0.40.4-0.9-0.2-0.5-1.0
Retroperitoneal fat weight1.25.07.9-2.8-2.72.72.8-2.42.32.3-2.0-1.6-1.91.9-1.9-2.0-2.4-1.4
Reaction time number correct0.10.20.5-0.5-0.40.40.3-0.50.70.7-0.3-0.4-0.30.2-0.5-0.2-0.4-0.7
Reaction time mean minus median0.10.20.9-0.4-0.4-0.0-0.20.3-0.6-0.60.40.3-0.20.20.60.40.90.3
Reaction time mean minus median AUC0.20.61.6-0.00.0-0.5-0.70.8-1.1-1.10.80.60.1-0.01.20.71.30.8
Reaction time num false alarms0.60.91.90.70.6-0.6-0.80.9-0.9-0.91.20.41.3-1.30.90.91.40.8
Reaction time num false alarms AUC0.50.72.00.70.7-0.8-0.90.8-0.5-0.50.90.21.2-1.30.80.91.40.5
Reaction time trials correct on left0.10.20.5-0.5-0.40.40.3-0.50.70.7-0.3-0.4-0.30.2-0.5-0.2-0.4-0.7
Reaction time trials on left0.10.10.3-0.4-0.40.30.2-0.40.50.5-0.1-0.2-0.20.2-0.3-0.1-0.3-0.6
Reaction time mean0.50.81.80.20.2-0.8-0.80.9-1.1-1.10.90.60.6-0.61.31.01.30.8
Reaction time mean AUC0.50.81.70.20.3-0.8-0.80.9-1.1-1.10.80.70.6-0.61.31.11.30.8
Median of all reaction times0.40.61.30.30.3-0.8-0.80.8-0.8-0.80.70.50.7-0.71.10.91.10.6
Reaction time omissions3.24.78.71.61.6-1.5-1.82.3-2.6-2.63.02.71.3-1.32.61.82.02.6
Reaction time false alarm rate0.60.92.30.80.8-0.8-0.90.9-0.7-0.70.90.21.3-1.30.81.01.50.7
Reaction time premature initiation rate0.20.30.80.80.9-0.9-0.30.5-0.6-0.60.80.50.4-0.40.10.10.30.5
Reaction time premature initiations0.10.10.30.50.5-0.6-0.20.2-0.3-0.30.60.40.2-0.2-0.1-0.1-0.10.1
Std. dev. reaction times0.10.31.1-0.5-0.5-0.1-0.20.4-0.6-0.60.60.2-0.20.20.80.51.10.4
Reaction time trials completed0.10.10.3-0.4-0.40.30.2-0.40.50.5-0.1-0.2-0.20.2-0.3-0.1-0.3-0.6
Reaction time trials AUC0.10.20.4-0.5-0.40.50.3-0.50.60.6-0.1-0.3-0.30.2-0.4-0.2-0.4-0.6
Run reversals in cocaine runway, females0.90.94.2-1.4-1.42.01.4-0.80.40.40.0-0.4-0.90.8-0.5-0.7-0.50.1
Run reversals in cocaine runway, males0.50.51.4-0.3-0.3-0.10.1-0.61.21.2-0.5-1.20.5-0.5-0.70.10.2-1.1
Latency to leave start box in cocaine runway0.70.81.60.60.6-0.8-1.01.0-1.2-1.20.51.30.5-0.41.30.80.81.1
Latency to leave start box in cocaine runway, F1.71.93.71.11.0-1.7-1.81.7-1.5-1.51.11.70.7-0.71.91.11.01.4
Latency to leave start box in cocaine runway, M0.10.10.4-0.2-0.10.70.6-0.3-0.1-0.1-0.30.1-0.10.1-0.2-0.0-0.10.2
Std. dev. time between licks in bursts0.50.71.4-0.7-0.70.80.9-1.01.01.0-1.2-0.8-0.40.4-1.0-0.9-0.3-0.8
Total sessions with >9 infusions0.20.20.8-0.6-0.6-0.1-0.70.30.20.2-0.9-0.2-0.20.00.10.60.1-0.9
Short access day 1 total inactive lever presses0.60.81.4-1.1-1.10.71.1-1.11.01.0-1.1-1.2-0.70.7-0.7-0.3-0.8-0.7
Short access day 10 total inactive lever presses0.41.02.6-0.7-0.80.20.4-0.70.80.8-1.4-1.2-1.01.0-0.9-1.2-1.6-1.3
Short access day 1 total infusions3.24.27.4-2.7-2.71.81.2-1.62.12.1-2.4-1.8-2.22.1-1.6-1.3-1.7-2.6
Short access day 10 total infusions0.40.51.4-1.2-1.20.70.3-0.30.60.6-0.6-0.3-0.90.8-0.2-0.5-0.5-0.7
Short access total infusions0.70.92.0-1.4-1.40.80.3-0.60.90.9-1.2-0.7-1.11.0-0.6-0.4-0.6-1.3
Short access day 1 locomotion1.51.83.0-1.7-1.71.10.8-1.01.21.2-1.7-1.3-1.61.5-1.1-0.9-1.3-1.7
Short access day 10 total locomotion0.20.41.20.40.4-0.8-1.11.0-0.6-0.60.11.00.5-0.60.90.50.30.2
Short access total locomotion0.30.41.0-0.9-1.00.40.1-0.30.60.6-0.9-0.5-0.70.6-0.3-0.3-0.4-1.0
One hour access (0.3 mA shock)1.01.12.7-0.7-0.70.60.8-1.21.61.6-1.1-1.2-0.70.7-1.3-1.0-0.4-1.4
Compulsive drug intake1.21.52.4-0.8-0.91.21.2-1.31.51.5-1.2-1.4-0.80.8-1.5-1.2-1.2-1.3
One hour access (shock baseline)0.40.72.50.80.8-0.8-0.80.7-0.4-0.40.80.70.8-0.80.80.91.60.6
Social response proportion0.20.21.1-0.1-0.20.40.4-0.20.10.1-0.0-0.1-0.40.5-0.6-0.8-1.0-0.2
Social responses0.30.41.30.60.5-0.7-0.3-0.00.50.5-0.6-0.1-0.50.5-0.9-0.9-1.1-0.9
Social time0.60.81.7-0.4-0.50.20.6-0.80.90.9-1.1-0.7-1.11.1-0.9-1.3-1.2-0.7
Soleus weight1.23.54.8-1.7-1.71.71.5-1.82.22.2-1.9-2.0-1.81.8-1.9-2.0-1.9-2.0
Bone: stiffness0.81.34.20.40.5-0.5-0.40.9-1.4-1.41.21.40.7-0.61.71.21.02.0
Tibialis anterior weight0.10.20.60.70.7-0.8-0.60.30.40.4-0.2-0.20.3-0.3-0.3-0.1-0.1-0.5
Time to tail flick, vehicle, before self-admin1.51.62.8-1.4-1.50.80.7-1.01.71.7-1.6-1.7-1.11.0-0.9-0.6-1.0-1.4
Time to tail flick, vehicle, after self-admin0.30.41.2-0.5-0.50.70.5-0.30.10.10.1-0.6-1.11.1-0.4-0.9-1.1-0.2
Time to tail flick, test, before self-admin0.30.31.50.1-0.00.70.5-0.0-0.6-0.61.20.3-0.50.5-0.1-0.3-0.00.6
Time to tail flick, test, after self-admin0.10.10.40.30.30.10.3-0.20.00.00.4-0.20.6-0.6-0.20.20.20.3
Delta time to tail flick, vehicle, before/after SA0.50.52.20.50.50.1-0.00.4-1.1-1.11.50.60.1-0.10.3-0.2-0.11.0
Delta time to tail flick, test, before/after SA0.20.20.50.00.1-0.3-0.1-0.20.40.4-0.7-0.60.6-0.6-0.10.20.2-0.3
Tibia length0.20.61.60.40.5-0.5-0.20.3-0.8-0.80.40.71.1-1.10.71.20.60.9
Ambulatory time before self-admin0.50.72.10.90.8-1.4-1.41.2-0.5-0.50.20.90.4-0.41.10.50.50.4
Ambulatory time after self-admin0.00.10.30.10.0-0.30.00.00.20.2-0.30.6-0.30.3-0.2-0.1-0.1-0.1
Bone: tissue strength0.10.10.40.30.3-0.1-0.10.2-0.3-0.30.20.30.6-0.70.20.20.50.4
Total heroin consumption1.11.32.81.21.2-1.7-1.51.4-1.4-1.40.41.40.7-0.71.30.80.21.0
Bone: trabecular number0.71.22.1-0.8-0.91.00.9-1.11.41.4-1.2-1.2-0.80.8-1.1-1.2-0.8-1.1
Bone: trabecular spacing0.10.10.6-0.2-0.1-0.4-0.30.3-0.6-0.60.10.30.2-0.20.50.8-0.10.3
Bone: trabecular thickness1.01.22.6-1.1-1.21.61.4-1.21.21.2-0.7-0.9-0.90.9-1.0-1.1-0.7-0.7
Bone: trabecular tissue density1.72.64.91.01.1-1.2-1.31.5-1.5-1.51.21.71.6-1.52.12.21.92.0
Water consumed over 24 hours0.10.20.90.60.6-0.7-0.30.3-0.2-0.20.1-0.1-0.30.3-0.4-0.5-0.9-0.3
Number of responses in last shaping day0.10.20.50.1-0.1-0.3-0.70.20.50.5-0.0-0.4-0.50.50.30.30.4-0.6