Hub : Genes

Amz2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Amz2 0.06 0.04 1.2e-03 0 0 0 -0 9.3e-02 1.0e-01 1.9e-01 3.8e-01
2 OFC gene expression Amz2 0.23 0.11 1.7e-04 0.17 0.2 0.15 0.2 8.7e-05 1.9e-05 1.9e-04 2.2e-05
3 PL gene expression Amz2 0.31 0.14 0.0e+00 0.22 0.2 0.21 0.21 4.4e-24 1.2e-21 2.0e-22 1.6e-22
4 IL gene expression Amz2 0.27 0.12 1.1e-04 0.15 0.14 0.1 0.13 2.2e-04 3.6e-04 2.4e-03 5.7e-04
5 BLA gene expression Amz2 0.23 0.08 1.9e-15 0.27 0.26 0.25 0.26 1.4e-14 7.2e-14 2.0e-13 7.6e-14
6 LHb gene expression Amz2 0.18 0.09 1.3e-03 0.15 0.1 0.12 0.13 2.1e-04 2.3e-03 7.4e-04 6.3e-04
7 NAcc gene expression Amz2 0.18 0.07 0.0e+00 0.2 0.2 0.2 0.2 1.4e-29 1.1e-29 2.5e-29 3.7e-30
8 IC gene expression Amz2 0.26 0.09 5.5e-13 0.35 0.31 0.3 0.33 2.5e-15 1.5e-13 2.9e-13 1.4e-14
9 NAcc alternative polyA XM_039086422.2 0.02 0.01 1.0e-03 0.02 0.03 0.02 0.02 5.7e-04 9.5e-05 1.7e-03 2.1e-04
10 NAcc alternative polyA XM_063269471.1 0.02 0.01 8.1e-03 0.01 0.02 0.01 0.01 1.9e-03 1.2e-03 4.7e-03 3.2e-03
11 NAcc alternative polyA XM_063269471.1 0.02 0.01 1.6e-03 0.02 0.02 0.01 0.02 1.3e-03 1.6e-04 2.1e-03 2.5e-04
12 pVTA gene expression Amz2 0.14 0.07 5.0e-10 0.15 0.12 0.13 0.14 2.8e-12 6.0e-10 7.9e-11 4.0e-11
13 Brain gene expression Amz2 0.18 0.07 0.0e+00 0.21 0.22 0.21 0.21 4.5e-19 5.3e-20 1.2e-19 2.4e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density3.45.89.90.2-3.0-3.0-3.2-3.1-3.1-3.1-2.1-0.70.60.8-2.6-2.7
Area under the delay curve0.20.20.6-0.60.20.30.10.30.30.30.20.7-0.8-0.80.10.7
BMI with tail5.920.228.8-2.75.25.15.15.35.35.15.22.4-2.0-2.55.44.8
BMI without tail9.127.938.3-3.46.16.26.26.26.26.26.12.4-2.0-2.56.25.6
Body weight9.240.551.2-6.06.76.66.36.66.66.67.05.4-5.0-5.56.97.2
Weight adjusted by age3.45.17.0-1.32.62.52.52.62.62.52.11.8-1.6-1.92.52.5
Bone surface3.15.69.5-1.4-3.0-2.9-3.1-3.0-3.0-3.0-2.20.7-0.9-0.6-2.7-2.0
Bone volume2.44.37.1-1.6-2.6-2.4-2.7-2.6-2.6-2.6-2.01.0-1.0-0.8-2.3-1.6
Breakpoint value in progressive ratio session0.50.61.11.01.10.60.50.60.60.70.7-1.01.00.90.50.3
Number of licking bursts0.20.40.9-0.90.40.40.20.30.30.20.51.0-1.0-1.00.30.7
Context. condit. distance diff. score0.20.20.4-0.50.30.30.50.30.30.40.30.6-0.6-0.60.50.5
Locomotion velocity, session 10.10.10.20.10.10.30.10.00.00.1-0.1-0.40.50.40.10.0
Locomotion distance, session 10.10.20.60.40.20.40.10.20.20.10.1-0.60.80.70.1-0.0
Locomotion velocity, session 20.80.92.60.9-0.6-0.4-0.5-0.4-0.4-0.5-0.7-1.51.61.6-0.7-1.0
Locomotion distance, session 20.71.03.71.2-0.3-0.1-0.2-0.1-0.1-0.3-0.3-1.71.91.8-0.3-1.0
Locomotion velocity, session 31.11.22.81.21.21.01.01.01.01.01.0-1.41.71.40.90.2
Locomotion distance, session 30.00.00.1-0.1-0.0-0.1-0.3-0.2-0.2-0.2-0.10.3-0.2-0.3-0.20.0
Stereotopy head waving bouts, day 33.03.59.83.1-0.9-0.9-0.9-1.0-1.0-0.9-1.6-2.82.82.8-1.4-1.7
Stereotopy head waving duration, day 31.82.15.52.3-0.8-0.8-0.8-0.9-0.9-0.8-1.3-2.12.12.1-1.2-1.3
Locomotion velocity, session 70.20.20.30.5-0.3-0.3-0.4-0.3-0.3-0.4-0.3-0.50.60.5-0.3-0.5
Locomotion distance, session 70.20.20.7-0.8-0.4-0.4-0.3-0.2-0.2-0.3-0.00.7-0.6-0.7-0.2-0.0
Stereotopy head waving bouts, day 71.61.83.61.8-0.8-0.9-1.1-1.0-1.0-1.0-0.5-1.91.91.9-0.7-1.6
Stereotopy head waving duration, day 72.73.26.22.5-1.1-1.3-1.5-1.4-1.4-1.4-0.9-2.52.42.4-1.1-2.0
Locomotion velocity, session 80.10.10.2-0.10.10.20.50.30.30.3-0.40.3-0.2-0.30.10.3
Locomotion distance, session 80.10.10.60.20.10.30.40.30.30.2-0.1-0.60.80.60.2-0.1
Degree of sensitization distance0.00.00.1-0.4-0.3-0.20.00.00.0-0.0-0.30.2-0.2-0.1-0.0-0.1
Degree of sensitization stereotypy0.50.61.91.0-0.1-0.2-0.4-0.3-0.3-0.30.4-1.31.41.30.1-0.8
Conditioned locomotion0.40.40.70.1-0.8-0.7-0.8-0.7-0.7-0.7-0.7-0.60.50.6-0.7-0.7
Cocaine response after cond. corrected0.40.51.7-1.0-0.4-0.3-0.4-0.4-0.4-0.3-0.21.3-1.3-1.2-0.00.2
Cocaine response after cond. not corrected0.50.61.9-1.1-0.4-0.3-0.4-0.4-0.4-0.4-0.21.3-1.4-1.3-0.10.2
Cocaine response before conditioning0.10.10.30.2-0.10.10.0-0.0-0.0-0.1-0.2-0.50.50.5-0.4-0.1
Saline control response3.95.28.4-0.82.92.82.82.72.72.82.90.3-0.1-0.42.62.3
Bone: connectivity density6.09.413.41.5-3.5-3.5-3.7-3.6-3.6-3.5-2.7-2.12.02.2-3.1-3.6
Bone: cortical apparent density1.01.45.62.40.50.60.50.60.60.6-0.2-1.91.91.90.1-0.3
Bone: cortical area0.20.31.0-1.00.40.80.40.50.50.60.30.10.0-0.10.40.5
Bone: cortical porosity0.40.43.0-1.7-0.7-0.4-0.4-0.3-0.3-0.4-0.00.7-0.7-0.6-0.2-0.2
Bone: cortical porosity0.91.04.9-2.20.20.40.50.60.60.50.71.4-1.3-1.30.60.8
Bone: cortical thickness2.84.67.02.02.32.42.02.22.22.21.7-2.42.72.31.90.8
Bone: cortical thickness1.82.27.52.40.20.30.10.10.10.2-0.1-2.72.72.60.0-0.9
Bone: cortical tissue density1.01.45.52.30.50.60.50.60.60.5-0.2-1.91.91.90.1-0.3
Condit. Reinf. active minus inactive responses1.41.53.7-1.90.71.00.91.11.11.00.71.6-1.6-1.50.71.4
Condit. Reinf. active-inactive response ratio0.30.31.2-0.9-0.1-0.1-0.10.00.0-0.00.00.9-1.1-0.9-0.10.5
Condit. Reinf. active responses0.70.92.9-1.70.40.80.70.90.90.70.51.2-1.1-1.10.61.0
Condit. Reinf. inactive responses0.00.00.2-0.4-0.10.20.10.20.20.10.0-0.00.20.10.2-0.1
Incentive salience index mean0.40.51.2-1.10.50.60.60.70.70.60.80.8-0.7-0.70.50.7
Condit. Reinf. lever presses0.20.31.10.30.60.50.50.60.60.41.0-0.40.40.40.60.1
Condit. Reinf. active minus inactive responses0.60.83.8-1.9-0.9-0.5-0.8-0.7-0.7-0.7-0.31.0-0.9-0.9-0.6-0.2
Condit. Reinf. active-inactive response ratio0.91.13.7-1.9-1.0-0.8-1.0-0.9-0.9-0.9-0.41.3-1.3-1.2-0.8-0.2
Condit. Reinf. active responses0.50.84.7-2.2-0.8-0.3-0.5-0.5-0.5-0.5-0.31.1-1.0-1.0-0.50.0
Condit. Reinf. inactive responses0.10.10.5-0.2-0.00.30.30.20.20.2-0.2-0.50.70.60.1-0.1
Condit. Reinf. lever presses0.30.42.7-1.60.10.40.40.40.40.40.60.6-0.5-0.60.30.5
Condit. Reinf. lever reinforcers received0.50.74.8-2.2-0.6-0.2-0.5-0.4-0.4-0.4-0.21.2-1.1-1.1-0.40.1
Conditioned reinforcement - actives0.50.91.8-0.0-1.2-1.1-1.1-1.1-1.1-1.1-1.3-0.20.20.3-1.1-0.8
Conditioned reinforcement - inactives0.20.41.2-0.80.20.30.20.20.20.10.21.1-1.0-1.10.10.6
Conditioned locomotion1.11.44.4-2.10.40.60.60.70.70.70.71.8-1.8-1.80.61.2
Patch foraging indifference point 0 sec2.13.86.1-2.01.92.42.42.52.52.41.61.0-0.7-0.91.82.1
Patch foraging indifference point AUC0.91.32.3-1.31.11.41.21.21.21.30.71.0-1.0-1.00.71.5
Delay disc. indifference point, 0s delay0.10.20.5-0.3-0.2-0.3-0.3-0.3-0.3-0.20.20.6-0.7-0.7-0.00.1
Delay disc. indifference point, 16s delay0.91.01.5-1.00.90.90.91.01.01.00.81.0-1.0-1.00.81.2
Delay disc. indifference point, 2s delay0.20.20.7-0.6-0.1-0.1-0.3-0.2-0.2-0.1-0.10.8-0.8-0.8-0.20.3
Delay disc. indifference point, 24s delay0.20.20.9-1.00.00.10.00.10.10.20.40.7-0.7-0.7-0.00.4
Delay disc. indifference point, 4s delay0.00.00.1-0.20.00.1-0.1-0.0-0.00.1-0.20.3-0.4-0.3-0.10.3
Delay disc. indifference point, 8s delay0.10.10.30.50.50.40.20.30.30.40.3-0.10.10.10.10.5
Indifference point function ln k1.52.65.11.8-1.3-1.4-1.3-1.2-1.2-1.3-1.3-2.12.32.2-1.1-1.8
Indifference point function log k1.52.65.11.8-1.3-1.4-1.3-1.2-1.2-1.3-1.3-2.12.32.2-1.1-1.8
Patch foraging total patch changes 0 sec2.03.76.1-1.81.92.52.42.52.52.41.60.8-0.5-0.81.92.0
Patch foraging total patch changes 12 sec1.41.94.6-2.21.01.51.31.31.31.40.81.3-1.3-1.30.81.6
Patch foraging total patch changes 18 sec2.64.06.5-1.32.32.52.52.52.52.51.70.8-0.6-0.91.82.3
Patch foraging total patch changes 24 sec0.71.33.0-1.71.01.31.21.21.21.30.80.9-0.7-0.90.51.3
Patch foraging total patch changes 6 sec4.87.411.1-3.32.63.12.72.72.72.82.02.5-2.4-2.62.23.3
Patch foraging time to switch 0 sec0.20.41.6-0.60.10.00.10.10.10.10.31.2-1.3-1.20.20.4
Patch foraging water rate 0 sec0.30.71.3-0.90.71.11.01.01.01.10.7-0.20.30.20.70.8
Patch foraging water rate 12 sec0.51.12.1-0.01.41.41.21.21.21.31.0-0.30.40.21.21.0
Patch foraging water rate 18 sec0.81.23.41.2-0.7-0.6-0.7-0.7-0.7-0.7-0.4-1.81.81.8-0.5-1.3
Patch foraging water rate 24 sec0.81.12.71.2-0.7-0.7-0.8-0.8-0.8-0.7-0.6-1.61.61.6-0.7-1.1
Patch foraging water rate 6 sec0.40.62.10.90.00.0-0.1-0.1-0.10.10.0-1.41.41.4-0.0-0.4
Seeking ratio, delayed vs. immediate footshock2.42.94.4-1.41.81.81.81.81.81.81.81.6-1.5-1.61.62.1
Distance traveled before self-admin0.10.20.50.10.70.50.50.50.50.60.30.0-0.0-0.10.50.5
Distance traveled after self-admin0.20.20.5-0.60.50.70.40.40.40.5-0.00.4-0.4-0.40.30.7
Extensor digitorum longus weight1.45.49.4-0.63.02.42.12.32.32.33.11.9-1.7-2.02.82.7
Bone: elastic displacement1.21.35.11.70.10.0-0.2-0.1-0.1-0.10.3-2.12.22.10.0-0.8
Bone: elastic work0.50.61.80.40.80.60.30.40.40.51.3-1.11.31.10.9-0.0
Bone: endosteal estimation4.49.733.2-5.8-1.8-1.2-1.6-1.6-1.6-1.5-1.15.0-5.2-4.8-1.40.9
Bone: endosteal perimeter4.29.032.3-5.7-1.8-1.3-1.5-1.5-1.5-1.5-1.24.7-4.8-4.6-1.30.8
Epididymis fat weight5.017.024.6-3.04.74.34.24.24.24.45.03.3-3.2-3.44.44.7
Delta time in closed arm before/after self-admin1.81.73.00.5-1.7-1.7-1.4-1.5-1.5-1.6-1.5-0.20.10.3-1.5-1.4
Delta time in open arm before/after self-admin0.70.72.31.5-0.3-0.5-0.6-0.6-0.6-0.6-0.4-1.21.31.2-0.5-0.9
Diff in mean of infusions in LGA sessions0.50.61.00.51.00.80.90.80.80.90.9-0.50.60.50.80.5
Delay discount exponential model param0.30.31.00.9-0.2-0.3-0.2-0.3-0.3-0.3-0.2-0.91.00.9-0.1-0.7
Extinction: sum of active levers before priming0.70.81.2-1.10.90.90.70.80.80.80.80.9-1.0-1.00.81.1
Active lever presses in extinction session 60.00.00.1-0.2-0.2-0.1-0.1-0.0-0.0-0.00.1-0.20.20.2-0.1-0.3
Bone: final force0.20.30.8-0.9-0.6-0.4-0.8-0.6-0.6-0.5-0.60.5-0.5-0.4-0.6-0.1
Bone: final moment0.20.40.8-0.8-0.7-0.4-0.9-0.7-0.7-0.6-0.80.3-0.4-0.3-0.7-0.3
Food consumed during 24 hour testing period2.63.66.30.32.42.52.42.32.32.31.9-0.50.60.42.41.7
Glucose0.20.30.8-0.20.70.20.10.20.20.30.60.8-0.7-0.90.80.7
Heart weight0.91.53.7-1.91.00.90.80.80.80.91.71.4-1.2-1.41.11.1
Delay discount hyperbolic model param0.30.31.00.8-0.2-0.3-0.1-0.2-0.2-0.3-0.2-1.01.01.0-0.1-0.7
Intermittent access intake day 1-15 change0.61.23.5-1.70.20.50.50.50.50.50.91.7-1.9-1.70.51.1
Intermittent access intake escalation0.71.43.1-1.80.50.90.80.80.80.81.11.6-1.6-1.50.91.2
Intermittent access intake escalation 20.91.03.5-1.8-0.10.10.10.10.10.20.41.7-1.9-1.70.20.8
Intermitt. access day 1 inactive lever presses0.31.01.2-1.10.81.11.01.01.00.91.01.1-1.0-1.10.91.1
Intermitt. access day 15 inactive lever presses0.81.72.0-1.41.11.31.31.31.31.21.31.4-1.4-1.41.31.3
Intermitt. access escalation Index0.10.10.30.10.10.20.20.20.20.30.5-0.50.50.50.3-0.0
Intermittent access day 1 total infusions0.10.20.6-0.10.40.40.50.50.50.50.4-0.60.80.60.40.1
Intermittent access day 15 total infusions1.11.73.9-2.00.91.21.31.31.31.31.41.2-1.1-1.11.21.4
Intermittent access terminal intake (last 3 days)0.91.24.8-2.20.30.50.60.60.60.60.81.5-1.6-1.50.61.1
Intermittent access total infusions0.20.31.3-1.10.20.40.40.50.50.50.40.4-0.3-0.40.40.6
Intermittent access day 1 locomotion1.51.92.7-1.61.21.51.61.61.61.51.60.9-0.6-0.81.51.3
Intermittent access day 15 total locomotion0.50.92.9-1.70.50.70.70.70.70.70.81.2-1.1-1.10.71.0
Intermittent access total locomotion2.42.95.2-2.31.41.71.81.81.81.81.81.4-1.1-1.31.71.8
Intermittent access standard deviation1.02.15.7-2.30.50.70.70.70.70.70.42.4-2.4-2.30.61.5
Left kidney weight0.41.83.8-0.91.61.41.41.61.61.52.00.5-0.4-0.51.81.3
Right kidney weight0.52.25.1-1.41.61.51.31.31.31.52.31.0-0.9-1.01.91.5
Cocaine induced anxiety1.21.72.7-0.1-1.6-1.6-1.6-1.6-1.6-1.6-1.60.5-0.6-0.4-1.5-1.1
Post-drug Anxiety1.11.11.70.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3-0.0-0.00.0-1.3-1.1
Baseline Anxiety0.40.50.60.50.70.80.80.80.80.70.7-0.70.70.70.60.2
Tail length1.97.59.9-3.02.93.02.82.82.83.03.02.0-1.9-2.02.83.1
Length with tail2.611.418.4-4.33.03.02.72.82.83.03.43.9-3.8-4.02.83.9
Length without tail1.44.69.9-2.61.61.51.21.41.41.42.03.1-3.1-3.11.52.4
Times rat made contact with spout0.60.61.4-0.60.90.90.90.90.90.81.20.1-0.1-0.11.10.8
Lifetime Intake0.30.30.7-0.80.50.60.70.70.70.70.60.00.10.00.60.5
Liver weight, left0.20.32.6-1.6-0.30.00.00.00.00.10.20.8-0.7-0.70.00.2
Liver weight, right0.71.22.50.31.31.41.31.41.41.31.2-0.40.50.41.60.8
Locomotor activity0.61.01.9-0.71.11.41.21.21.21.21.4-0.20.40.20.90.8
Locomotor testing distance0.91.63.4-0.91.51.81.51.61.61.51.7-0.00.30.01.01.1
Locomotor testing rearing1.73.46.5-1.02.32.52.22.32.32.22.30.20.1-0.21.61.9
Locomotion in novel chamber0.10.10.20.20.40.40.40.50.50.40.30.2-0.3-0.30.40.3
Locomotion in novel chamber post-restriction0.10.10.30.3-0.3-0.2-0.0-0.1-0.1-0.10.1-0.50.40.5-0.1-0.4
Fecal boli incidents, locomotor time 10.60.81.5-1.1-1.0-0.8-0.8-0.7-0.7-0.7-0.91.2-1.2-1.1-0.6-0.2
Change in fecal boli incidents, locomotor task0.00.00.2-0.10.00.3-0.0-0.0-0.00.1-0.40.1-0.3-0.1-0.40.3
Time >=10cm from walls, locomotor time 10.60.61.61.3-0.4-0.5-0.3-0.5-0.5-0.5-0.9-1.11.21.1-0.6-0.9
Bouts of movement, locomotor time 10.70.71.3-0.60.91.01.11.01.01.01.00.5-0.4-0.51.00.8
Total resting periods, locomotor time 10.30.30.5-0.60.50.50.70.50.50.50.70.6-0.6-0.60.60.5
Rest time, locomotor task time 10.20.30.50.0-0.3-0.7-0.6-0.7-0.7-0.5-0.20.6-0.7-0.7-0.5-0.1
Distance moved, locomotor task time 10.81.22.20.61.41.51.21.31.31.31.0-0.70.70.61.30.8
Vertical activity count, locomotor time 10.40.91.80.51.11.31.11.21.21.10.5-0.60.60.50.90.8
Time >=10cm from walls, locomotor time 21.21.72.90.41.71.61.71.71.71.71.3-0.50.60.41.41.0
Bouts of movement, locomotor time 22.23.56.0-0.22.52.22.32.42.42.42.00.3-0.2-0.42.21.9
Total resting periods, locomotor time 21.52.74.8-0.22.21.92.02.12.12.11.70.4-0.3-0.51.81.7
Rest time, locomotor task time 22.02.64.71.3-1.6-1.9-2.0-2.0-2.0-1.9-1.7-0.20.00.1-2.2-1.5
Distance moved, locomotor task time 22.32.84.20.72.02.02.02.02.02.01.9-1.01.00.92.01.1
Vertical activity count, locomotor time 21.72.33.9-0.21.72.02.01.91.91.91.6-0.60.60.51.91.2
Light reinforcement 10.61.42.40.81.31.41.11.21.21.11.3-1.41.61.30.90.4
Light reinforcement 20.10.20.90.30.50.20.30.50.50.30.9-0.10.20.10.20.2
Bone: marrow area4.39.531.8-5.6-1.8-1.2-1.6-1.6-1.6-1.5-1.24.9-5.1-4.7-1.40.9
Bone: maximum diameter1.42.66.3-2.5-1.6-1.2-1.6-1.5-1.5-1.4-1.41.9-2.0-1.8-1.5-0.2
Bone: maximum force0.40.73.1-1.7-0.7-0.4-0.8-0.6-0.6-0.5-0.51.2-1.2-1.1-0.50.1
Bone: maximum moment0.40.72.8-1.7-0.7-0.4-0.8-0.6-0.6-0.6-0.61.1-1.1-1.0-0.60.0
Mean time between licks in bursts0.92.14.5-1.61.30.91.00.80.81.01.52.1-2.1-2.11.31.6
Mean num. licks in bursts0.10.20.80.60.10.10.30.20.20.20.2-0.80.90.80.3-0.2
Cd content in liver0.90.91.90.8-1.0-1.1-1.4-1.1-1.1-1.2-1.10.0-0.2-0.0-1.3-0.7
Co content in liver0.00.00.20.10.1-0.10.1-0.0-0.0-0.10.50.3-0.3-0.30.2-0.0
Cu content in liver0.10.10.4-0.5-0.3-0.1-0.2-0.2-0.2-0.2-0.20.6-0.6-0.6-0.1-0.1
Fe content in liver0.10.10.3-0.1-0.4-0.4-0.5-0.5-0.5-0.5-0.4-0.00.00.0-0.6-0.3
K content in liver1.01.01.60.5-1.2-1.0-1.1-1.0-1.0-1.1-0.8-0.90.80.9-1.1-1.3
Mg content in liver3.73.75.51.6-2.1-1.9-2.0-2.0-2.0-2.0-1.7-1.81.71.9-2.0-2.3
Mn content in liver4.24.76.82.0-2.1-2.0-2.1-2.0-2.0-2.0-1.9-2.42.32.4-2.1-2.6
Na content in liver0.50.60.90.7-0.7-0.8-0.9-0.9-0.9-0.8-0.9-0.50.40.5-0.9-0.7
Rb content in liver0.70.81.61.3-0.7-0.8-0.8-0.9-0.9-0.9-1.0-0.80.70.7-0.9-0.8
Se content in liver0.30.41.51.0-0.0-0.2-0.2-0.1-0.1-0.1-0.1-1.11.21.1-0.1-0.6
Sr content in liver1.21.11.5-0.91.01.01.21.21.21.11.10.8-0.7-0.81.11.0
Zn content in liver0.60.71.20.2-1.1-0.9-0.9-1.0-1.0-1.0-0.7-0.30.30.3-0.8-1.0
Bone: minimum diameter2.95.324.0-4.9-0.7-0.1-0.5-0.3-0.3-0.3-0.13.8-3.8-3.7-0.21.2
Time in familiar zone, hab. session 10.90.83.0-1.4-0.10.10.00.00.00.0-0.21.7-1.7-1.6-0.00.7
Time in novel zone, hab. session 10.70.72.81.10.0-0.10.10.10.10.00.2-1.61.71.60.2-0.7
Total zone transitions, hab. session 10.71.02.6-0.01.11.11.11.01.01.11.6-0.40.60.41.40.6
Total locomotion distance, hab. session 10.91.22.00.31.31.41.21.21.21.21.3-0.91.00.81.30.6
Locomotion velocity, hab. session 10.81.11.80.31.31.31.21.21.21.21.3-0.70.90.71.30.6
Time in familiar zone, hab. session 20.70.72.2-1.50.20.50.30.30.30.30.11.4-1.4-1.30.20.9
Time in novel zone, hab. session 22.22.24.32.1-1.1-1.3-1.0-1.0-1.0-1.1-0.9-2.12.02.1-0.9-1.8
Total zone transitions, hab. session 21.11.43.30.41.41.21.41.21.21.31.8-0.81.10.81.60.5
Total locomotion distance, hab. session 21.72.23.30.81.81.81.81.71.71.71.5-1.11.31.11.70.9
Locomotion velocity, hab. session 21.41.92.61.11.61.61.61.41.41.51.3-1.41.51.31.40.6
Novel to familiar place preference ratio1.11.24.9-2.20.20.40.20.30.30.30.51.8-1.8-1.80.30.9
Novelty place preference0.80.83.3-1.80.10.20.10.10.10.20.51.5-1.5-1.50.20.7
Time in novel zone, NPP test0.60.62.7-1.70.00.10.00.10.10.10.31.3-1.2-1.30.10.5
Total zone transitions, NPP test0.91.44.51.20.60.90.90.80.80.70.5-1.92.11.90.6-0.2
Total locomotion distance, NPP test1.41.95.81.50.71.11.01.01.00.90.4-2.32.42.30.6-0.3
Locomotion velocity, NPP test1.42.04.11.21.21.61.41.51.51.30.8-1.82.01.81.10.3
Intraocular pressure0.71.01.7-1.11.01.11.21.11.11.10.90.6-0.3-0.51.31.0
Delta distance traveled before/after self-admin0.10.10.30.10.20.50.20.30.30.30.1-0.50.50.50.30.0
Delta ambulatory time before/after self-admin0.10.10.4-0.7-0.5-0.0-0.4-0.3-0.3-0.4-0.50.3-0.4-0.3-0.3-0.2
Parametrial fat weight0.61.32.70.1-1.6-1.5-1.2-1.3-1.3-1.4-1.5-0.1-0.20.1-1.4-1.2
Pavlov. Cond. lever latency2.63.37.91.0-2.1-1.9-2.1-2.0-2.0-2.1-2.8-0.70.50.7-2.3-1.6
Pavlov. Cond. magazine entry latency0.50.61.2-1.10.60.70.80.90.90.80.90.7-0.7-0.70.70.8
Pavlov. Cond. change in total contacts1.51.63.9-1.31.21.11.31.41.41.32.00.9-0.8-0.91.51.1
Pavlov. Cond. index score1.31.72.7-1.41.21.21.41.51.51.31.71.0-1.0-1.01.41.2
Pavlov. Cond. latency score1.82.34.5-1.51.51.41.61.61.61.62.11.1-1.0-1.11.71.4
Pavlov. Cond. lever contacts2.12.56.3-1.01.81.61.71.71.71.72.50.8-0.6-0.82.01.4
Pavlov. Cond. magazine entry number0.50.61.41.2-0.4-0.5-0.7-0.7-0.7-0.6-0.6-0.91.00.9-0.5-0.7
Pavlov. Cond. intertrial magazine entries1.61.94.4-2.10.91.21.11.11.11.10.91.8-1.6-1.81.11.5
Pavlov. Cond. lever-magazine prob. diff.0.91.12.1-1.20.90.91.11.21.21.11.40.8-0.7-0.71.10.9
Pavlov. Cond. response bias0.40.40.9-0.80.50.50.80.80.80.71.00.5-0.5-0.50.60.5
Pavlov. Cond. lever latency0.30.50.90.51.00.60.80.60.60.80.70.3-0.4-0.41.00.7
Pavlov. Cond. magazine entry latency0.10.10.4-0.10.00.20.10.20.20.0-0.60.5-0.6-0.6-0.40.4
Pavlov. Cond. change in total contacts0.20.30.5-0.7-0.7-0.4-0.7-0.5-0.5-0.6-0.70.2-0.1-0.1-0.7-0.3
Pavlov. Cond. index score0.30.30.8-0.9-0.7-0.4-0.6-0.4-0.4-0.6-0.80.5-0.4-0.4-0.9-0.2
Pavlov. Cond. latency score0.20.30.8-0.7-0.6-0.3-0.5-0.3-0.3-0.5-0.80.4-0.3-0.3-0.9-0.2
Pavlov. Cond. lever contacts0.30.50.8-0.3-0.9-0.6-0.8-0.6-0.6-0.7-0.7-0.60.60.6-0.9-0.8
Pavlov. Cond. magazine entry number0.10.10.1-0.1-0.2-0.3-0.1-0.3-0.3-0.10.3-0.30.20.30.3-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.3-0.6-0.5-0.20.0-0.2-0.2-0.2-0.1-0.0-0.00.1-0.1-0.4
Pavlov. Cond. lever-magazine prob. diff.0.20.30.8-0.8-0.7-0.4-0.6-0.4-0.4-0.6-0.80.5-0.4-0.4-0.9-0.2
Pavlov. Cond. response bias0.40.51.0-0.4-1.0-0.7-0.9-0.7-0.7-0.8-0.8-0.20.20.3-1.0-0.7
Time in closed arm before self-admin2.12.64.8-0.31.72.02.22.12.12.01.7-0.60.80.52.11.1
Time in closed arm after self-admin1.01.02.0-0.31.11.11.41.31.31.21.10.1-0.0-0.11.30.8
Time in open arm before self-admin1.01.12.4-0.81.00.80.70.70.70.70.71.5-1.6-1.60.71.4
Time in open arm after self-admin0.20.20.9-0.30.40.10.00.00.00.10.20.9-0.8-0.90.10.6
Bone: periosteal estimation2.24.619.5-4.4-1.2-0.5-1.0-0.9-0.9-0.9-0.83.4-3.4-3.2-0.90.8
Bone: periosteal perimeter2.03.513.6-3.7-0.7-0.3-0.7-0.6-0.6-0.5-0.53.1-3.1-3.0-0.50.9
Bone: post-yield work1.11.55.5-2.3-0.4-0.3-0.3-0.2-0.2-0.30.02.2-2.2-2.1-0.10.5
Progressive ratio test 1 active lever presses2.42.94.4-1.02.12.02.12.12.12.12.10.10.1-0.22.11.7
Progressive ratio test 1 breakpoint2.12.63.9-1.01.91.92.02.02.02.02.00.10.1-0.12.01.6
Progressive ratio test 1 inactive lever presses2.13.04.4-1.81.72.12.12.02.02.02.00.5-0.4-0.52.11.7
Progressive ratio test 2 active lever presses0.50.51.0-0.51.00.80.80.80.80.90.80.3-0.2-0.30.81.0
Progressive ratio test 2 breakpoint0.50.61.1-0.61.00.80.80.90.91.00.80.4-0.3-0.40.81.0
Progressive ratio test 2 inactive lever presses0.30.50.8-0.50.70.90.80.80.80.80.90.2-0.1-0.20.70.7
Incentive Sensitization - Responses0.20.20.7-0.50.40.10.10.10.10.30.10.8-0.8-0.90.00.7
Incentive Sensitization - Breakpoint0.20.30.9-0.50.30.10.00.10.10.20.00.9-0.9-0.9-0.00.7
Sum of active levers in priming session hrs 5-60.40.30.80.40.90.80.50.60.60.70.5-0.50.50.40.50.5
Progressive ratio0.30.41.5-0.5-0.1-0.1-0.2-0.3-0.3-0.2-0.51.2-1.2-1.2-0.00.4
Food seeking constrained by brief footshock0.30.31.0-0.5-0.7-1.0-0.7-0.6-0.6-0.6-0.30.5-0.6-0.50.0-0.4
Seeking ratio, punishment vs. effort0.10.20.50.00.10.00.20.30.30.20.5-0.70.70.70.3-0.3
Retroperitoneal fat weight2.410.117.1-2.43.63.33.33.33.33.44.12.2-2.1-2.33.73.4
Reaction time number correct0.71.31.91.0-1.1-1.4-1.4-1.3-1.3-1.3-0.9-0.91.01.0-1.2-1.2
Reaction time mean minus median0.10.20.6-0.30.20.10.00.10.10.10.50.6-0.7-0.60.50.3
Reaction time mean minus median AUC0.30.81.50.4-1.0-1.2-1.2-1.1-1.1-1.1-0.7-0.50.30.5-0.8-1.0
Reaction time num false alarms0.91.33.5-1.90.71.01.01.01.01.00.71.4-1.2-1.30.61.2
Reaction time num false alarms AUC0.50.83.4-1.80.30.70.70.70.70.70.41.2-1.0-1.10.40.8
Reaction time trials correct on left0.71.31.91.0-1.1-1.4-1.4-1.3-1.3-1.3-0.9-0.91.01.0-1.2-1.2
Reaction time trials on left0.71.42.10.9-1.1-1.4-1.4-1.3-1.3-1.4-0.9-0.90.90.9-1.3-1.3
Reaction time mean0.40.61.20.5-1.0-0.9-0.9-0.8-0.8-0.8-1.1-0.30.00.3-0.8-0.8
Reaction time mean AUC0.30.50.80.6-0.9-0.8-0.8-0.7-0.7-0.7-0.9-0.50.20.5-0.7-0.8
Median of all reaction times0.81.12.20.8-1.3-1.2-1.1-1.1-1.1-1.1-1.5-0.60.30.6-1.1-1.1
Reaction time omissions0.30.40.80.1-0.9-0.7-0.8-0.7-0.7-0.7-0.4-0.30.10.3-0.4-0.8
Reaction time false alarm rate1.31.84.0-2.00.91.31.41.31.31.30.81.6-1.4-1.51.01.4
Reaction time premature initiation rate1.82.53.9-1.81.31.61.41.51.51.51.11.8-1.8-1.80.92.0
Reaction time premature initiations0.20.41.2-1.10.30.50.30.40.40.30.21.0-1.0-1.0-0.10.8
Std. dev. reaction times0.30.51.00.3-1.0-1.0-0.9-0.9-0.9-0.8-0.8-0.2-0.10.2-0.7-0.8
Reaction time trials completed0.71.42.10.9-1.1-1.4-1.4-1.3-1.3-1.4-0.9-0.90.90.9-1.3-1.3
Reaction time trials AUC0.71.31.91.0-1.1-1.4-1.4-1.3-1.3-1.3-1.0-0.90.90.9-1.3-1.2
Run reversals in cocaine runway, females5.15.17.0-1.22.62.32.52.32.32.42.51.8-1.8-1.92.52.6
Run reversals in cocaine runway, males0.10.10.5-0.5-0.4-0.2-0.2-0.2-0.2-0.2-0.40.6-0.7-0.60.1-0.1
Latency to leave start box in cocaine runway2.02.33.31.61.71.61.81.81.81.60.7-1.41.51.31.40.8
Latency to leave start box in cocaine runway, F3.03.46.30.62.52.12.52.52.52.41.4-0.20.40.12.11.8
Latency to leave start box in cocaine runway, M1.41.34.41.70.00.30.10.20.20.1-0.2-2.12.02.1-0.0-0.7
Std. dev. time between licks in bursts0.20.30.80.90.70.40.50.40.40.50.7-0.50.60.50.40.2
Total sessions with >9 infusions1.41.72.9-0.21.71.61.61.61.61.61.5-0.30.50.21.61.2
Short access day 1 total inactive lever presses0.10.10.3-0.10.60.60.40.40.40.40.20.2-0.0-0.20.30.5
Short access day 10 total inactive lever presses0.00.10.2-0.2-0.3-0.1-0.2-0.2-0.2-0.2-0.10.3-0.4-0.3-0.2-0.1
Short access day 1 total infusions0.91.22.10.21.41.31.21.21.21.21.2-0.71.00.71.20.8
Short access day 10 total infusions1.92.43.6-1.41.61.81.91.91.91.91.90.20.0-0.21.91.4
Short access total infusions0.50.60.8-0.30.80.90.90.90.90.90.8-0.50.80.50.90.5
Short access day 1 locomotion3.64.47.0-0.82.62.52.52.52.52.52.60.4-0.1-0.42.52.2
Short access day 10 total locomotion1.52.93.9-1.91.41.81.91.91.91.72.01.4-1.2-1.41.81.7
Short access total locomotion3.64.36.8-1.32.32.42.52.52.52.42.60.8-0.5-0.82.42.1
One hour access (0.3 mA shock)0.20.20.7-0.8-0.4-0.5-0.4-0.3-0.3-0.3-0.30.5-0.5-0.5-0.40.1
Compulsive drug intake0.60.71.2-1.1-1.0-0.9-0.9-0.8-0.8-0.7-0.60.8-0.9-0.8-0.8-0.3
One hour access (shock baseline)0.00.00.1-0.20.20.20.20.20.20.20.20.1-0.0-0.00.20.2
Social response proportion0.40.51.8-1.4-0.6-0.4-0.3-0.3-0.3-0.4-0.31.0-1.1-0.9-0.0-0.1
Social responses0.30.41.5-1.20.40.80.70.70.70.60.50.4-0.3-0.30.70.6
Social time0.50.71.8-1.3-0.8-0.6-0.5-0.7-0.7-0.6-0.11.3-1.3-1.20.1-0.1
Soleus weight0.51.53.4-1.80.80.60.20.40.40.51.41.9-1.7-1.81.21.1
Bone: stiffness0.40.61.8-1.3-0.6-0.4-0.5-0.4-0.4-0.4-0.61.2-1.3-1.1-0.50.1
Tibialis anterior weight1.24.09.7-1.52.32.01.81.81.81.93.11.5-1.4-1.62.62.0
Time to tail flick, vehicle, before self-admin0.50.61.1-0.2-0.7-0.8-0.8-0.7-0.7-0.8-0.50.9-1.1-0.9-0.9-0.1
Time to tail flick, vehicle, after self-admin0.60.71.5-0.7-0.6-1.0-0.8-0.9-0.9-0.8-0.41.2-1.2-1.1-0.7-0.0
Time to tail flick, test, before self-admin1.31.34.2-2.1-0.10.30.20.30.30.20.42.0-2.0-1.90.20.7
Time to tail flick, test, after self-admin0.30.31.4-1.2-0.4-0.1-0.0-0.1-0.1-0.1-0.40.9-0.9-0.80.00.1
Delta time to tail flick, vehicle, before/after SA0.50.40.8-0.3-0.9-0.9-0.8-0.9-0.9-0.8-0.70.2-0.3-0.2-0.6-0.5
Delta time to tail flick, test, before/after SA0.60.61.50.3-0.9-1.0-0.7-0.9-0.9-0.8-1.2-0.20.20.2-0.7-0.7
Tibia length1.54.26.1-1.82.22.21.92.12.12.02.12.0-2.0-2.11.82.5
Ambulatory time before self-admin0.30.41.00.51.00.70.70.70.70.80.4-0.40.40.30.60.5
Ambulatory time after self-admin0.20.20.6-0.30.60.80.50.50.50.5-0.00.1-0.2-0.10.40.6
Bone: tissue strength0.70.72.21.4-0.2-0.2-0.3-0.3-0.3-0.3-0.5-1.41.51.4-0.4-0.7
Total heroin consumption0.10.20.30.4-0.3-0.1-0.4-0.4-0.4-0.3-0.3-0.50.50.6-0.5-0.4
Bone: trabecular number4.67.511.51.0-3.2-3.2-3.4-3.2-3.2-3.3-2.5-1.61.51.7-2.9-3.2
Bone: trabecular spacing2.33.04.9-0.42.12.22.12.22.22.11.30.9-0.9-0.91.72.1
Bone: trabecular thickness0.81.02.0-0.8-1.4-1.2-1.2-1.2-1.2-1.2-1.00.3-0.2-0.2-1.0-1.0
Bone: trabecular tissue density0.60.91.60.21.01.21.21.31.31.20.10.4-0.4-0.40.61.2
Water consumed over 24 hours1.11.42.61.31.11.11.11.11.11.00.9-1.61.61.51.00.2
Number of responses in last shaping day1.41.52.7-0.41.41.71.61.51.51.51.20.2-0.1-0.21.61.2