Hub : Genes

Amotl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Amotl2 0.37 0.16 1.2e-05 0.23 0.25 0.22 0.23 3.7e-06 1.3e-06 5.2e-06 3.5e-06
2 Brain gene expression Amotl2 0.1 0.06 3.9e-10 0.06 0.1 0.09 0.09 6.3e-06 8.8e-10 1.2e-08 1.9e-08
3 IC gene expression Amotl2 0.08 0.05 2.6e-03 0.04 0.04 0.03 0.03 1.4e-02 7.3e-03 2.6e-02 2.6e-02
4 pVTA gene expression Amotl2 0.11 0.06 4.6e-07 0.06 0.09 0.08 0.09 1.0e-05 2.2e-07 3.6e-07 9.3e-08
5 BLA gene expression Amotl2 0.25 0.14 3.2e-11 0.19 0.13 0.21 0.12 2.4e-10 2.9e-07 2.7e-11 8.5e-07
6 NAcc gene expression Amotl2 0.11 0.06 0.0e+00 0.12 0.12 0.13 0.13 5.6e-18 5.3e-18 2.4e-19 3.9e-19
7 PL gene expression Amotl2 0.03 0.02 1.4e-03 0.01 0.01 0.01 0.01 3.8e-02 2.2e-02 6.5e-02 6.0e-02
8 Brain mRNA stability Amotl2 0.1 0.07 9.8e-06 0.07 0.05 0.06 0.06 5.2e-07 1.5e-05 4.2e-06 1.1e-06
9 RMTg gene expression Amotl2 0.18 0.12 6.7e-03 0.13 0.1 0.11 0.12 2.4e-04 1.5e-03 7.4e-04 4.0e-04
10 Adipose mRNA stability Amotl2 0.15 0.08 1.5e-11 0.09 0.08 0.09 0.08 3.7e-10 1.3e-09 7.0e-10 2.2e-09
11 Adipose alternative TSS XM_039082102.2 0.08 0.05 1.0e-04 0.04 0.02 0.03 0.03 8.6e-05 1.4e-03 2.5e-04 7.8e-04
12 Adipose alternative TSS XM_006243680.5 0.06 0.04 5.7e-04 0.03 0.02 0.03 0.02 3.0e-04 5.3e-03 7.7e-04 2.0e-03
13 Adipose alternative TSS XM_039082102.2 0.07 0.05 3.2e-04 0.03 0.02 0.03 0.02 1.6e-04 3.1e-03 3.1e-04 9.2e-04
14 Adipose isoform ratio XM_039082102.2 0.07 0.05 6.0e-04 0.03 0.02 0.03 0.02 4.0e-04 6.2e-03 6.9e-04 2.8e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.91.62.70.21.11.31.0-1.3-1.31.50.40.01.6-1.51.5-1.5-1.5
Area under the delay curve1.32.14.81.70.60.30.80.0-0.1-0.11.0-1.5-2.22.0-2.02.02.0
BMI with tail0.41.52.81.71.11.11.2-0.5-0.70.81.3-1.7-1.71.2-1.21.21.2
BMI without tail1.89.719.04.13.53.53.8-3.0-3.13.13.8-4.4-2.01.9-1.91.91.9
Body weight2.510.821.34.64.03.83.9-3.3-3.43.24.1-3.9-2.41.9-1.91.91.9
Weight adjusted by age0.10.41.20.70.70.60.6-1.1-0.90.60.9-0.3-0.10.5-0.50.50.5
Bone surface1.32.55.9-1.3-0.10.3-0.4-0.2-0.10.5-1.31.42.4-2.42.4-2.4-2.4
Bone volume0.91.74.3-0.60.50.70.2-0.7-0.71.0-0.50.72.1-2.02.0-2.0-2.0
Breakpoint value in progressive ratio session0.30.61.4-0.7-1.0-1.2-0.80.61.0-1.1-0.50.0-0.50.7-0.70.70.7
Number of licking bursts0.00.00.20.0-0.00.00.4-0.2-0.30.10.2-0.40.0-0.20.2-0.2-0.2
Context. condit. distance diff. score3.94.79.02.53.02.92.7-2.9-2.82.82.6-1.80.2-0.60.6-0.6-0.6
Locomotion velocity, session 10.50.61.20.30.80.90.6-1.1-0.90.90.4-0.10.8-0.80.8-0.8-0.8
Locomotion distance, session 11.21.53.00.21.01.30.7-1.1-1.01.30.1-0.11.4-1.71.7-1.7-1.7
Locomotion velocity, session 20.00.00.10.20.1-0.1-0.1-0.3-0.1-0.10.30.2-0.30.0-0.00.00.0
Locomotion distance, session 20.00.10.20.40.40.3-0.1-0.4-0.00.10.20.0-0.50.0-0.00.00.0
Locomotion velocity, session 30.30.30.50.20.60.70.4-0.7-0.60.70.3-0.30.6-0.70.7-0.7-0.7
Locomotion distance, session 30.40.51.1-0.6-0.10.1-0.40.20.20.1-0.70.60.8-1.11.1-1.1-1.1
Stereotopy head waving bouts, day 30.30.40.7-0.3-0.6-0.7-0.50.60.5-0.7-0.20.1-0.50.8-0.80.80.8
Stereotopy head waving duration, day 30.30.30.80.0-0.3-0.4-0.30.40.5-0.4-0.1-0.2-0.50.9-0.90.90.9
Locomotion velocity, session 70.70.71.20.41.01.00.7-1.0-1.11.10.4-0.30.8-0.90.9-0.9-0.9
Locomotion distance, session 70.00.00.20.00.0-0.1-0.20.0-0.0-0.1-0.00.4-0.20.2-0.20.20.2
Stereotopy head waving bouts, day 70.50.61.6-0.40.10.4-0.1-0.1-0.20.4-0.30.31.0-1.31.3-1.3-1.3
Stereotopy head waving duration, day 70.40.51.4-0.30.20.50.1-0.2-0.30.6-0.2-0.11.0-1.21.2-1.2-1.2
Locomotion velocity, session 82.32.85.11.62.22.22.0-2.3-2.12.21.8-1.40.6-0.90.9-0.9-0.9
Locomotion distance, session 83.34.89.52.43.02.92.5-3.1-2.82.82.4-1.60.3-0.90.9-0.9-0.9
Degree of sensitization distance0.50.51.40.60.2-0.10.4-0.2-0.3-0.10.7-0.3-0.91.2-1.21.21.2
Degree of sensitization stereotypy1.41.53.5-0.10.71.10.5-0.8-0.91.20.0-0.11.6-1.91.9-1.9-1.9
Conditioned locomotion0.30.41.2-1.0-0.4-0.4-0.30.0-0.0-0.0-0.60.71.1-0.70.7-0.7-0.7
Cocaine response after cond. corrected0.81.22.90.5-0.4-0.7-0.10.60.4-0.90.5-0.3-1.71.7-1.71.71.7
Cocaine response after cond. not corrected0.71.03.00.8-0.0-0.30.20.20.1-0.50.8-0.5-1.71.5-1.51.51.5
Cocaine response before conditioning0.40.50.90.60.91.00.8-1.0-0.90.90.7-0.40.3-0.50.5-0.5-0.5
Saline control response1.11.53.01.01.51.71.4-1.5-1.41.61.0-1.20.6-0.90.9-0.9-0.9
Bone: connectivity density0.20.30.60.10.50.60.5-0.6-0.60.70.20.00.8-0.70.7-0.7-0.7
Bone: cortical apparent density0.71.12.3-1.2-0.6-0.4-0.60.60.4-0.2-1.00.81.1-1.51.5-1.5-1.5
Bone: cortical area1.52.54.80.81.82.01.6-1.8-1.92.20.7-0.81.6-1.51.5-1.5-1.5
Bone: cortical porosity1.71.84.7-0.70.30.70.1-0.5-0.50.9-0.80.42.2-2.12.1-2.1-2.1
Bone: cortical porosity1.61.74.2-0.60.40.80.1-0.6-0.50.9-0.70.32.1-2.02.0-2.0-2.0
Bone: cortical thickness1.01.73.31.21.71.81.7-1.6-1.71.81.3-1.40.5-0.40.4-0.4-0.4
Bone: cortical thickness0.20.20.50.00.40.60.5-0.5-0.50.70.1-0.40.7-0.50.5-0.5-0.5
Bone: cortical tissue density0.61.02.1-1.1-0.6-0.4-0.60.50.4-0.2-1.00.81.1-1.51.5-1.5-1.5
Condit. Reinf. active minus inactive responses0.20.20.70.60.20.20.3-0.1-0.1-0.00.6-0.5-0.80.4-0.40.40.4
Condit. Reinf. active-inactive response ratio1.51.62.81.31.61.71.5-1.5-1.61.61.3-1.30.3-0.70.7-0.7-0.7
Condit. Reinf. active responses0.70.92.90.2-0.7-0.8-0.40.70.7-1.10.3-0.1-1.71.2-1.21.21.2
Condit. Reinf. inactive responses1.31.73.0-0.6-1.4-1.6-1.31.41.5-1.7-0.50.8-1.41.3-1.31.31.3
Incentive salience index mean0.40.51.40.0-0.6-0.7-0.50.80.8-0.9-0.00.1-1.20.8-0.80.80.8
Condit. Reinf. lever presses1.01.52.6-0.5-1.3-1.4-1.31.51.5-1.6-0.70.7-1.31.2-1.21.21.2
Condit. Reinf. active minus inactive responses2.13.26.5-0.9-1.9-2.0-2.02.42.5-2.3-1.61.0-1.51.4-1.41.41.4
Condit. Reinf. active-inactive response ratio1.32.15.20.8-0.5-0.7-0.51.01.1-1.10.1-0.6-2.32.1-2.12.12.1
Condit. Reinf. active responses3.04.48.6-1.4-2.4-2.5-2.52.72.9-2.7-1.81.6-1.41.5-1.51.51.5
Condit. Reinf. inactive responses2.53.87.0-2.5-2.4-2.3-2.52.22.3-2.2-2.22.70.7-0.60.6-0.6-0.6
Condit. Reinf. lever presses1.82.64.7-1.0-1.9-2.0-1.72.12.1-2.2-1.21.2-1.41.3-1.31.31.3
Condit. Reinf. lever reinforcers received3.44.89.2-1.4-2.5-2.6-2.52.93.0-2.9-1.81.4-1.71.7-1.71.71.7
Conditioned reinforcement - actives0.41.72.91.51.51.51.6-1.5-1.41.51.7-1.5-0.70.8-0.80.80.8
Conditioned reinforcement - inactives0.00.00.10.20.20.20.3-0.0-0.30.20.2-0.2-0.1-0.10.1-0.1-0.1
Conditioned locomotion0.40.61.10.50.70.80.9-1.0-0.80.90.8-1.00.10.6-0.60.60.6
Patch foraging indifference point 0 sec0.10.41.10.30.80.90.6-0.9-0.51.00.2-0.51.1-0.30.3-0.3-0.3
Patch foraging indifference point AUC0.61.32.3-0.2-1.0-1.1-0.71.31.0-1.3-0.50.3-1.31.5-1.51.51.5
Delay disc. indifference point, 0s delay0.50.61.20.90.30.20.50.0-0.0-0.00.4-1.0-1.01.1-1.11.11.1
Delay disc. indifference point, 16s delay0.81.13.01.40.70.50.7-0.3-0.30.21.0-1.1-1.71.3-1.31.31.3
Delay disc. indifference point, 2s delay0.80.92.21.50.90.61.0-0.5-0.60.30.9-1.4-0.91.1-1.11.11.1
Delay disc. indifference point, 24s delay1.11.84.91.20.1-0.30.30.30.2-0.60.8-0.8-2.22.1-2.12.12.1
Delay disc. indifference point, 4s delay1.01.12.71.20.30.10.30.20.1-0.30.6-0.8-1.61.6-1.61.61.6
Delay disc. indifference point, 8s delay0.71.12.61.10.20.10.50.30.2-0.20.5-1.1-1.61.5-1.51.51.5
Indifference point function ln k0.41.23.2-0.40.30.60.2-0.4-0.30.7-0.20.21.4-1.81.8-1.8-1.8
Indifference point function log k0.41.23.2-0.40.30.60.2-0.4-0.30.7-0.20.21.4-1.81.8-1.8-1.8
Patch foraging total patch changes 0 sec0.00.11.0-0.10.30.50.2-0.4-0.10.5-0.1-0.21.0-0.10.1-0.1-0.1
Patch foraging total patch changes 12 sec0.20.30.4-0.5-0.6-0.6-0.50.60.6-0.5-0.40.4-0.10.7-0.70.70.7
Patch foraging total patch changes 18 sec0.30.71.30.81.01.11.2-1.1-0.91.10.9-0.90.20.5-0.50.50.5
Patch foraging total patch changes 24 sec0.00.10.10.20.10.10.20.10.10.10.2-0.3-0.20.4-0.40.40.4
Patch foraging total patch changes 6 sec0.10.10.9-0.6-0.20.1-0.20.20.10.1-0.40.31.0-0.20.2-0.2-0.2
Patch foraging time to switch 0 sec0.10.40.7-0.10.40.50.5-0.8-0.70.70.3-0.10.8-0.70.7-0.7-0.7
Patch foraging water rate 0 sec0.41.53.71.00.0-0.10.10.50.5-0.40.4-0.8-1.91.9-1.91.91.9
Patch foraging water rate 12 sec0.41.63.92.01.31.11.5-0.8-0.90.71.5-1.9-1.31.1-1.11.11.1
Patch foraging water rate 18 sec0.41.02.21.51.21.11.1-0.9-0.90.91.2-1.5-0.90.3-0.30.30.3
Patch foraging water rate 24 sec1.21.73.01.51.21.11.3-1.1-0.90.91.4-1.7-1.31.3-1.31.31.3
Patch foraging water rate 6 sec1.11.63.41.81.10.81.2-0.7-0.70.51.4-1.7-1.61.4-1.41.41.4
Seeking ratio, delayed vs. immediate footshock0.81.23.4-1.1-0.10.2-0.3-0.3-0.20.4-0.70.71.8-1.61.6-1.6-1.6
Distance traveled before self-admin0.61.44.21.51.41.51.4-1.0-0.91.31.0-2.0-0.20.7-0.70.70.7
Distance traveled after self-admin0.40.81.90.71.10.91.0-1.3-1.41.01.1-0.50.5-0.60.6-0.6-0.6
Extensor digitorum longus weight0.72.97.21.30.1-0.30.30.30.4-0.71.0-1.2-2.62.7-2.72.72.7
Bone: elastic displacement1.01.22.31.31.41.31.5-1.4-1.31.31.2-1.3-0.10.4-0.40.40.4
Bone: elastic work3.04.08.01.82.62.82.6-2.5-2.52.81.6-2.11.1-0.70.7-0.7-0.7
Bone: endosteal estimation0.51.33.3-0.10.81.10.4-0.8-0.81.2-0.40.31.8-1.61.6-1.6-1.6
Bone: endosteal perimeter0.20.40.9-0.7-0.3-0.1-0.40.20.2-0.0-0.80.81.0-0.80.8-0.8-0.8
Epididymis fat weight0.10.71.41.10.50.50.20.20.30.10.3-0.9-1.11.2-1.21.21.2
Delta time in closed arm before/after self-admin0.20.20.70.30.40.80.30.0-0.20.6-0.2-0.20.3-0.40.4-0.4-0.4
Delta time in open arm before/after self-admin0.20.21.0-0.7-0.4-0.1-0.20.40.40.1-0.6-0.21.0-0.50.5-0.5-0.5
Diff in mean of infusions in LGA sessions0.20.30.60.0-0.3-0.2-0.20.30.6-0.2-0.1-0.7-0.70.8-0.80.80.8
Delay discount exponential model param1.72.35.1-1.8-0.7-0.4-0.90.00.20.1-1.11.62.3-2.12.1-2.1-2.1
Extinction: sum of active levers before priming0.20.41.00.50.70.90.6-0.6-0.40.80.1-1.00.2-0.50.5-0.5-0.5
Active lever presses in extinction session 60.60.61.40.60.00.10.20.20.2-0.10.2-1.2-1.21.1-1.11.11.1
Bone: final force0.71.12.31.11.51.51.3-1.3-1.41.50.9-1.00.5-0.40.4-0.4-0.4
Bone: final moment1.01.63.21.21.71.81.5-1.5-1.61.81.0-1.10.7-0.60.6-0.6-0.6
Food consumed during 24 hour testing period0.61.12.31.01.41.51.1-1.3-1.31.40.7-0.80.4-0.90.9-0.9-0.9
Glucose2.94.68.83.02.42.12.4-2.0-2.21.72.8-2.5-1.41.7-1.71.71.7
Heart weight1.01.52.81.71.21.31.2-0.7-0.70.91.3-1.6-1.31.3-1.31.31.3
Delay discount hyperbolic model param1.41.84.0-1.6-0.5-0.2-0.7-0.10.10.1-0.91.42.0-1.91.9-1.9-1.9
Intermittent access intake day 1-15 change0.31.62.51.61.00.91.3-0.6-1.00.71.5-1.1-1.51.4-1.41.41.4
Intermittent access intake escalation0.21.12.01.40.90.91.2-0.6-0.90.61.4-0.9-1.31.0-1.01.01.0
Intermittent access intake escalation 20.10.20.50.40.30.20.5-0.2-0.50.20.7-0.0-0.60.3-0.30.30.3
Intermitt. access day 1 inactive lever presses0.00.20.7-0.7-0.6-0.4-0.50.50.4-0.4-0.40.8-0.1-0.30.3-0.3-0.3
Intermitt. access day 15 inactive lever presses0.21.12.6-1.3-0.6-0.4-0.70.40.4-0.2-0.71.10.9-1.61.6-1.6-1.6
Intermitt. access escalation Index0.10.20.70.3-0.10.2-0.50.60.8-0.1-0.6-0.3-0.50.3-0.30.30.3
Intermittent access day 1 total infusions0.20.71.50.40.20.10.4-0.6-0.30.20.9-0.6-1.21.2-1.21.21.2
Intermittent access day 15 total infusions0.81.94.31.50.90.71.1-0.8-0.80.51.7-1.2-2.11.7-1.71.71.7
Intermittent access terminal intake (last 3 days)1.83.26.12.21.71.41.9-1.8-1.71.32.5-1.7-1.91.7-1.71.71.7
Intermittent access total infusions1.72.03.71.61.31.21.5-1.4-1.41.21.9-1.4-1.51.3-1.31.31.3
Intermittent access day 1 locomotion0.51.02.80.1-0.3-0.6-0.10.10.2-0.50.4-0.3-1.31.7-1.71.71.7
Intermittent access day 15 total locomotion0.62.44.01.51.31.21.7-1.5-1.41.32.0-1.9-1.41.5-1.51.51.5
Intermittent access total locomotion1.61.92.81.21.00.81.3-1.3-1.20.91.7-1.4-1.41.7-1.71.71.7
Intermittent access standard deviation0.00.21.3-0.4-0.4-0.7-0.40.0-0.1-0.60.41.1-0.20.3-0.30.30.3
Left kidney weight0.54.28.01.12.42.81.8-2.1-2.12.80.8-0.82.3-2.12.1-2.1-2.1
Right kidney weight0.42.66.11.82.42.51.7-2.1-2.02.31.2-1.00.9-0.60.6-0.6-0.6
Cocaine induced anxiety0.30.71.3-0.8-0.6-0.5-0.70.50.5-0.4-0.81.10.5-1.11.1-1.1-1.1
Post-drug Anxiety0.10.10.60.2-0.1-0.2-0.10.10.1-0.40.20.6-0.70.0-0.00.00.0
Baseline Anxiety0.40.81.81.00.50.40.6-0.4-0.40.11.1-0.7-1.31.1-1.11.11.1
Tail length2.010.618.14.24.03.74.0-3.9-3.73.44.0-3.8-1.41.7-1.71.71.7
Length with tail1.67.213.53.73.43.23.3-3.2-3.02.83.3-2.9-1.31.3-1.31.31.3
Length without tail0.42.14.82.21.71.51.6-1.4-1.31.11.9-1.3-1.51.1-1.11.11.1
Times rat made contact with spout0.40.40.70.10.50.50.2-0.8-0.70.60.00.60.8-0.90.9-0.9-0.9
Lifetime Intake1.11.42.31.20.90.71.0-1.1-0.90.71.5-0.9-1.51.4-1.41.41.4
Liver weight, left0.20.41.10.60.30.2-0.0-0.10.2-0.00.4-0.3-1.01.0-1.01.01.0
Liver weight, right0.40.61.41.20.80.60.6-0.7-0.50.50.9-0.6-1.10.8-0.80.80.8
Locomotor activity0.60.92.21.31.31.21.1-1.1-1.11.11.5-1.0-0.4-0.20.2-0.2-0.2
Locomotor testing distance0.30.61.00.70.91.00.8-0.8-0.90.91.0-0.50.2-0.80.8-0.8-0.8
Locomotor testing rearing0.10.51.4-0.4-0.9-1.0-0.81.21.0-1.2-0.50.5-0.80.2-0.20.20.2
Locomotion in novel chamber1.21.74.4-1.6-1.6-1.8-1.61.31.3-1.5-1.12.1-0.2-0.60.6-0.6-0.6
Locomotion in novel chamber post-restriction0.10.41.60.70.2-0.00.5-0.1-0.2-0.10.8-0.7-1.30.8-0.80.80.8
Fecal boli incidents, locomotor time 10.41.13.60.8-0.1-0.5-0.20.30.5-0.90.6-0.2-1.91.6-1.61.61.6
Change in fecal boli incidents, locomotor task1.71.83.8-0.30.71.00.6-1.1-1.11.30.10.31.9-1.91.9-1.9-1.9
Time >=10cm from walls, locomotor time 10.81.02.2-1.1-1.0-0.9-1.31.11.0-0.9-1.21.50.6-0.70.7-0.7-0.7
Bouts of movement, locomotor time 10.20.30.6-0.7-0.8-0.7-0.50.60.6-0.6-0.50.30.1-0.30.3-0.3-0.3
Total resting periods, locomotor time 10.30.40.8-0.7-0.9-0.8-0.70.80.9-0.8-0.70.4-0.0-0.10.1-0.1-0.1
Rest time, locomotor task time 10.30.51.2-0.5-0.7-0.8-1.10.71.0-0.8-0.60.8-0.50.5-0.50.50.5
Distance moved, locomotor task time 10.30.82.10.70.91.01.4-0.9-1.31.10.9-1.50.50.0-0.00.00.0
Vertical activity count, locomotor time 10.00.00.1-0.2-0.2-0.20.10.30.1-0.2-0.2-0.30.30.1-0.10.10.1
Time >=10cm from walls, locomotor time 20.30.91.6-0.1-0.8-1.0-0.91.01.1-1.3-0.50.4-1.11.0-1.01.01.0
Bouts of movement, locomotor time 20.31.01.5-0.5-1.0-1.0-0.81.00.9-1.1-0.30.6-1.11.2-1.21.21.2
Total resting periods, locomotor time 20.20.91.5-0.5-1.0-1.0-0.81.00.9-1.0-0.40.6-1.01.2-1.21.21.2
Rest time, locomotor task time 20.20.30.8-0.4-0.5-0.6-0.80.30.6-0.6-0.50.9-0.00.4-0.40.40.4
Distance moved, locomotor task time 20.60.81.30.20.70.91.1-0.7-1.11.10.4-1.21.1-0.80.8-0.8-0.8
Vertical activity count, locomotor time 20.61.52.5-1.6-1.2-0.8-1.11.21.1-0.7-1.60.81.2-1.31.3-1.3-1.3
Light reinforcement 10.83.46.41.90.90.41.3-0.8-0.70.12.2-1.9-2.52.5-2.52.52.5
Light reinforcement 21.22.85.72.11.91.72.0-2.0-1.91.52.4-2.1-0.70.9-0.90.90.9
Bone: marrow area0.61.43.4-0.10.81.20.4-0.8-0.81.2-0.40.21.8-1.61.6-1.6-1.6
Bone: maximum diameter0.71.32.60.11.01.20.7-1.0-1.01.4-0.10.01.6-1.51.5-1.5-1.5
Bone: maximum force1.52.95.51.02.02.31.7-2.1-2.12.30.9-1.01.7-1.51.5-1.5-1.5
Bone: maximum moment1.93.66.61.22.32.51.9-2.2-2.32.61.0-1.11.8-1.71.7-1.7-1.7
Mean time between licks in bursts0.00.20.6-0.4-0.6-0.7-0.50.70.8-0.7-0.40.2-0.10.3-0.30.30.3
Mean num. licks in bursts0.10.20.40.20.60.60.1-0.6-0.40.6-0.00.60.7-0.50.5-0.5-0.5
Cd content in liver0.91.01.91.11.31.21.4-1.3-1.31.21.3-1.30.00.1-0.10.10.1
Co content in liver0.30.40.7-0.6-0.8-0.8-0.60.60.7-0.8-0.40.4-0.40.6-0.60.60.6
Cu content in liver1.21.43.5-0.70.10.60.2-0.3-0.30.8-0.7-0.31.6-1.91.9-1.9-1.9
Fe content in liver0.60.81.80.81.11.31.1-1.0-1.01.30.5-1.30.5-0.30.3-0.3-0.3
K content in liver4.54.48.4-0.2-1.7-2.0-1.12.11.9-2.2-0.5-0.0-2.62.9-2.92.92.9
Mg content in liver2.22.44.1-0.4-1.4-1.8-1.01.71.5-1.8-0.60.2-1.62.0-2.02.02.0
Mn content in liver0.50.61.5-0.6-1.0-1.0-0.71.20.8-1.0-0.80.1-0.30.7-0.70.70.7
Na content in liver0.10.10.30.2-0.10.0-0.10.20.4-0.2-0.1-0.2-0.60.4-0.40.40.4
Rb content in liver2.83.38.31.50.3-0.10.70.20.0-0.41.3-1.6-2.42.9-2.92.92.9
Se content in liver0.00.00.2-0.1-0.00.10.20.1-0.10.1-0.1-0.20.4-0.30.3-0.3-0.3
Sr content in liver0.40.30.70.60.50.40.7-0.4-0.60.50.8-0.8-0.50.5-0.50.50.5
Zn content in liver0.60.71.50.1-0.6-0.7-0.10.80.6-0.70.2-0.6-1.11.2-1.21.21.2
Bone: minimum diameter0.71.33.2-0.10.81.00.6-0.9-1.01.2-0.10.01.8-1.61.6-1.6-1.6
Time in familiar zone, hab. session 12.02.23.8-1.8-0.8-0.6-1.20.70.6-0.3-1.81.81.9-1.81.8-1.8-1.8
Time in novel zone, hab. session 13.23.57.12.51.71.52.2-1.4-1.61.22.5-2.7-1.71.7-1.71.71.7
Total zone transitions, hab. session 10.50.82.81.20.60.30.4-0.4-0.10.00.9-0.8-1.71.0-1.01.01.0
Total locomotion distance, hab. session 10.10.20.5-0.4-0.5-0.6-0.60.30.7-0.6-0.30.5-0.40.1-0.10.10.1
Locomotion velocity, hab. session 10.10.20.6-0.3-0.4-0.5-0.70.20.8-0.6-0.30.5-0.50.1-0.10.10.1
Time in familiar zone, hab. session 20.50.51.1-1.0-0.9-1.0-0.80.70.7-0.8-0.90.90.4-0.30.3-0.3-0.3
Time in novel zone, hab. session 21.41.53.31.31.51.81.5-1.4-1.51.71.2-1.40.3-0.60.6-0.6-0.6
Total zone transitions, hab. session 20.10.10.40.2-0.1-0.3-0.40.10.3-0.40.10.2-0.6-0.00.0-0.0-0.0
Total locomotion distance, hab. session 20.81.12.3-1.1-1.0-1.2-1.50.91.1-1.1-1.11.50.2-0.70.7-0.7-0.7
Locomotion velocity, hab. session 21.21.63.4-1.4-1.3-1.3-1.81.11.4-1.2-1.51.90.4-1.01.0-1.0-1.0
Novel to familiar place preference ratio0.60.81.30.10.81.10.5-0.8-0.81.20.2-0.21.1-1.21.2-1.2-1.2
Novelty place preference1.01.32.00.21.01.30.8-1.1-1.11.40.4-0.41.3-1.41.4-1.4-1.4
Time in novel zone, NPP test0.81.01.70.30.91.30.8-1.0-1.11.30.5-0.41.0-1.11.1-1.1-1.1
Total zone transitions, NPP test0.10.10.90.50.1-0.1-0.2-0.10.2-0.30.40.1-0.90.4-0.40.40.4
Total locomotion distance, NPP test0.60.81.6-0.3-0.9-1.1-1.00.71.1-1.3-0.30.7-1.20.8-0.80.80.8
Locomotion velocity, NPP test0.50.61.3-0.4-0.9-1.1-1.10.71.1-1.1-0.50.8-0.90.5-0.50.50.5
Intraocular pressure0.40.71.50.10.70.90.4-0.6-0.80.90.00.11.2-1.11.1-1.1-1.1
Delta distance traveled before/after self-admin0.90.92.2-0.30.40.40.4-0.8-1.00.70.30.51.2-1.51.5-1.5-1.5
Delta ambulatory time before/after self-admin0.50.91.9-0.20.50.40.5-0.9-1.10.70.50.41.0-1.41.4-1.4-1.4
Parametrial fat weight2.55.910.13.22.72.42.8-2.3-2.52.13.0-3.0-1.61.9-1.91.91.9
Pavlov. Cond. lever latency0.81.12.01.41.31.21.4-1.2-1.11.11.4-1.3-0.60.2-0.20.20.2
Pavlov. Cond. magazine entry latency1.82.44.2-2.0-1.4-1.1-1.91.21.3-1.0-2.11.91.3-1.51.5-1.5-1.5
Pavlov. Cond. change in total contacts2.02.14.3-1.8-1.7-1.6-2.01.61.6-1.6-1.82.10.5-0.50.5-0.5-0.5
Pavlov. Cond. index score1.82.34.3-2.1-1.6-1.4-1.91.41.5-1.3-2.02.01.2-1.11.1-1.1-1.1
Pavlov. Cond. latency score1.31.73.2-1.8-1.3-1.1-1.61.21.2-0.9-1.81.71.2-1.01.0-1.0-1.0
Pavlov. Cond. lever contacts1.01.22.5-1.6-1.2-1.0-1.41.00.9-0.8-1.51.51.1-0.60.6-0.6-0.6
Pavlov. Cond. magazine entry number2.32.95.12.21.81.52.2-1.6-1.71.42.3-2.2-1.11.2-1.21.21.2
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.10.20.30.1-0.2-0.20.30.10.40.5-0.50.5-0.5-0.5
Pavlov. Cond. lever-magazine prob. diff.2.43.05.5-2.3-2.0-1.8-2.21.81.8-1.6-2.22.31.0-1.01.0-1.0-1.0
Pavlov. Cond. response bias1.62.03.8-1.9-1.6-1.5-1.91.41.4-1.3-1.91.90.9-0.80.8-0.8-0.8
Pavlov. Cond. lever latency2.73.87.31.62.52.62.2-2.6-2.62.71.7-1.51.3-1.11.1-1.1-1.1
Pavlov. Cond. magazine entry latency1.52.13.8-1.7-1.9-1.9-1.91.71.8-1.8-1.71.80.1-0.10.1-0.1-0.1
Pavlov. Cond. change in total contacts1.53.77.6-1.2-2.3-2.6-2.12.42.5-2.7-1.31.3-1.71.4-1.41.41.4
Pavlov. Cond. index score2.33.66.9-1.8-2.5-2.6-2.32.52.6-2.6-1.81.8-0.90.7-0.70.70.7
Pavlov. Cond. latency score2.13.46.3-1.9-2.4-2.5-2.32.42.4-2.5-2.01.9-0.50.4-0.40.40.4
Pavlov. Cond. lever contacts2.23.26.2-1.4-2.3-2.4-2.02.42.4-2.5-1.51.4-1.11.0-1.01.01.0
Pavlov. Cond. magazine entry number3.95.19.12.42.93.03.0-2.9-3.02.92.5-2.50.4-0.40.4-0.4-0.4
Pavlov. Cond. intertrial magazine entries0.20.51.1-0.6-0.8-0.7-0.91.01.0-0.9-0.60.7-0.50.1-0.10.10.1
Pavlov. Cond. lever-magazine prob. diff.2.63.97.6-1.7-2.5-2.7-2.42.62.7-2.8-1.81.8-1.10.9-0.90.90.9
Pavlov. Cond. response bias4.05.610.7-1.8-2.9-3.2-2.73.13.1-3.3-1.91.9-1.61.5-1.51.51.5
Time in closed arm before self-admin0.20.30.6-0.4-0.6-0.8-0.70.60.5-0.7-0.20.7-0.20.5-0.50.50.5
Time in closed arm after self-admin0.70.81.6-0.6-1.0-1.0-1.11.21.2-1.1-0.80.9-0.60.6-0.60.60.6
Time in open arm before self-admin0.30.40.60.30.50.50.7-0.7-0.70.50.5-0.20.2-0.80.8-0.8-0.8
Time in open arm after self-admin1.11.23.0-0.8-0.20.30.10.3-0.10.4-0.8-0.21.7-1.71.7-1.7-1.7
Bone: periosteal estimation1.43.35.60.51.82.21.4-1.8-1.92.30.3-0.42.4-2.12.1-2.1-2.1
Bone: periosteal perimeter0.40.82.3-0.50.20.50.1-0.3-0.40.7-0.60.51.5-1.31.3-1.3-1.3
Bone: post-yield work0.00.00.20.40.10.00.1-0.10.0-0.20.3-0.2-0.50.2-0.20.20.2
Progressive ratio test 1 active lever presses1.32.43.41.61.21.01.7-1.3-1.31.11.8-1.7-1.61.7-1.71.71.7
Progressive ratio test 1 breakpoint1.42.43.31.61.20.91.6-1.2-1.31.01.8-1.8-1.71.8-1.81.81.8
Progressive ratio test 1 inactive lever presses0.10.20.7-0.1-0.3-0.4-0.00.10.1-0.30.40.0-0.80.6-0.60.60.6
Progressive ratio test 2 active lever presses1.11.53.01.61.20.81.2-1.2-1.00.81.7-1.0-1.61.2-1.21.21.2
Progressive ratio test 2 breakpoint1.21.63.11.61.20.81.2-1.2-1.00.81.8-1.0-1.71.2-1.21.21.2
Progressive ratio test 2 inactive lever presses0.10.41.00.60.60.30.5-0.8-0.70.31.0-0.1-0.60.6-0.60.60.6
Incentive Sensitization - Responses0.41.22.91.31.51.11.3-1.7-1.41.21.6-0.7-0.70.3-0.30.30.3
Incentive Sensitization - Breakpoint0.51.12.61.31.41.01.2-1.6-1.31.11.6-0.6-0.70.3-0.30.30.3
Sum of active levers in priming session hrs 5-60.40.41.20.60.60.40.7-0.8-0.70.50.6-1.1-0.20.6-0.60.60.6
Progressive ratio0.61.63.0-1.3-1.6-1.7-1.41.21.3-1.6-0.91.5-0.61.1-1.11.11.1
Food seeking constrained by brief footshock1.31.73.51.11.61.71.6-1.9-1.81.81.3-1.10.8-0.40.4-0.4-0.4
Seeking ratio, punishment vs. effort1.83.97.42.02.52.72.3-2.4-2.42.61.8-2.10.8-1.11.1-1.1-1.1
Retroperitoneal fat weight1.67.011.53.32.11.72.0-1.6-1.61.13.1-2.5-3.43.2-3.23.23.2
Reaction time number correct0.10.30.80.90.50.40.6-0.4-0.40.30.5-0.9-0.50.5-0.50.50.5
Reaction time mean minus median0.10.92.1-0.1-0.9-0.9-0.81.51.3-1.1-0.5-0.2-1.40.9-0.90.90.9
Reaction time mean minus median AUC0.21.13.80.4-0.6-0.7-0.31.21.0-0.90.1-0.7-2.01.3-1.31.31.3
Reaction time num false alarms0.30.51.0-0.7-0.9-1.0-0.81.00.9-1.0-0.70.5-0.10.1-0.10.10.1
Reaction time num false alarms AUC0.10.20.4-0.5-0.6-0.7-0.40.60.5-0.6-0.40.40.10.1-0.10.10.1
Reaction time trials correct on left0.10.30.80.90.50.40.6-0.4-0.40.30.5-0.9-0.50.5-0.50.50.5
Reaction time trials on left0.10.30.80.90.50.40.6-0.3-0.40.20.5-0.9-0.60.6-0.60.60.6
Reaction time mean0.51.23.0-1.2-1.5-1.3-1.31.71.6-1.3-1.30.7-0.5-0.00.0-0.0-0.0
Reaction time mean AUC0.51.23.0-1.2-1.5-1.3-1.31.71.5-1.3-1.40.6-0.3-0.10.1-0.1-0.1
Median of all reaction times0.91.42.7-1.5-1.6-1.3-1.41.61.4-1.3-1.51.00.1-0.50.5-0.5-0.5
Reaction time omissions1.22.04.1-0.2-1.3-1.4-1.11.81.6-1.8-0.40.0-2.01.5-1.51.51.5
Reaction time false alarm rate0.20.20.5-0.7-0.7-0.7-0.50.60.5-0.5-0.50.60.3-0.20.2-0.2-0.2
Reaction time premature initiation rate2.43.88.02.31.40.81.6-1.2-1.40.62.8-1.8-2.62.3-2.32.32.3
Reaction time premature initiations1.23.87.22.41.30.71.6-1.1-1.20.42.7-1.9-2.72.3-2.32.32.3
Std. dev. reaction times0.41.33.5-0.8-1.4-1.3-1.31.91.7-1.5-1.10.2-1.10.5-0.50.50.5
Reaction time trials completed0.10.30.80.90.50.40.6-0.3-0.40.20.5-0.9-0.60.6-0.60.60.6
Reaction time trials AUC0.10.41.01.00.60.50.7-0.4-0.50.30.6-1.0-0.60.6-0.60.60.6
Run reversals in cocaine runway, females1.21.42.6-1.5-1.5-1.4-1.61.41.4-1.3-1.41.50.1-0.20.2-0.2-0.2
Run reversals in cocaine runway, males1.21.42.81.31.71.51.3-1.7-1.71.61.3-0.70.4-0.40.4-0.4-0.4
Latency to leave start box in cocaine runway4.46.111.2-3.3-3.1-2.7-3.02.92.9-2.5-3.12.51.3-1.31.3-1.3-1.3
Latency to leave start box in cocaine runway, F3.03.87.3-2.5-2.6-2.3-2.52.72.7-2.3-2.51.60.4-0.50.5-0.5-0.5
Latency to leave start box in cocaine runway, M2.42.34.4-2.1-1.6-1.4-1.61.21.1-1.1-1.72.11.3-1.41.4-1.4-1.4
Std. dev. time between licks in bursts2.13.97.9-2.0-2.6-2.8-2.22.62.6-2.7-1.81.6-0.80.9-0.90.90.9
Total sessions with >9 infusions0.80.92.60.4-0.1-0.40.00.00.2-0.40.4-0.2-1.41.6-1.61.61.6
Short access day 1 total inactive lever presses0.20.30.9-0.9-0.5-0.5-0.90.40.7-0.3-0.81.00.4-0.20.2-0.2-0.2
Short access day 10 total inactive lever presses0.11.02.0-1.2-1.0-1.1-1.31.01.0-1.0-1.31.40.6-0.50.5-0.5-0.5
Short access day 1 total infusions0.10.10.4-0.2-0.1-0.2-0.50.00.4-0.2-0.40.6-0.00.4-0.40.40.4
Short access day 10 total infusions2.13.55.71.91.41.11.5-1.5-1.31.02.2-1.8-2.12.4-2.42.42.4
Short access total infusions0.81.12.90.60.2-0.10.2-0.2-0.0-0.10.7-0.4-1.51.7-1.71.71.7
Short access day 1 locomotion0.20.40.90.50.30.20.3-0.30.10.10.2-0.7-0.70.9-0.90.90.9
Short access day 10 total locomotion0.51.95.20.3-0.4-0.8-0.20.10.3-0.90.5-0.1-1.92.3-2.32.32.3
Short access total locomotion1.01.64.30.6-0.1-0.40.2-0.10.0-0.40.7-0.7-1.82.1-2.12.12.1
One hour access (0.3 mA shock)1.61.94.21.60.90.71.0-0.8-0.70.31.5-0.9-2.01.8-1.81.81.8
Compulsive drug intake1.11.63.6-1.1-1.4-1.5-1.71.41.6-1.7-1.61.90.20.1-0.10.10.1
One hour access (shock baseline)1.94.97.22.62.12.02.5-2.0-2.01.82.7-2.6-2.22.1-2.12.12.1
Social response proportion0.20.30.5-0.6-0.6-0.7-0.60.70.6-0.6-0.60.60.30.3-0.30.30.3
Social responses1.41.84.80.7-0.3-0.7-0.30.60.4-1.00.5-0.1-1.82.2-2.22.22.2
Social time2.54.07.2-2.3-2.7-2.6-2.62.72.7-2.6-2.22.1-0.10.2-0.20.20.2
Soleus weight5.215.328.35.34.64.14.7-4.0-4.03.64.7-5.0-2.42.6-2.62.62.6
Bone: stiffness0.50.92.3-0.30.40.60.0-0.5-0.50.7-0.40.61.4-1.51.5-1.5-1.5
Tibialis anterior weight0.10.30.70.2-0.2-0.3-0.00.30.3-0.40.1-0.4-0.80.9-0.90.90.9
Time to tail flick, vehicle, before self-admin0.40.51.50.50.2-0.10.1-0.10.1-0.20.5-0.2-1.21.1-1.11.11.1
Time to tail flick, vehicle, after self-admin0.61.22.6-1.5-1.3-1.3-1.41.11.2-1.0-1.31.60.60.1-0.10.10.1
Time to tail flick, test, before self-admin0.20.20.50.70.60.60.4-0.3-0.20.40.4-0.4-0.70.3-0.30.30.3
Time to tail flick, test, after self-admin0.20.20.50.40.60.70.6-0.4-0.60.60.2-0.60.6-0.30.3-0.3-0.3
Delta time to tail flick, vehicle, before/after SA1.21.32.9-1.6-1.0-0.6-1.00.90.8-0.3-1.61.11.7-1.11.1-1.1-1.1
Delta time to tail flick, test, before/after SA0.10.20.7-0.20.00.30.10.1-0.10.3-0.4-0.40.8-0.60.6-0.6-0.6
Tibia length0.92.64.50.41.51.80.9-1.7-1.41.90.2-0.02.0-2.12.1-2.1-2.1
Ambulatory time before self-admin0.41.34.41.51.01.11.1-0.6-0.50.81.0-2.1-0.91.2-1.21.21.2
Ambulatory time after self-admin0.60.92.00.91.00.91.3-1.2-1.41.01.4-1.2-0.20.4-0.40.40.4
Bone: tissue strength4.34.58.93.02.62.32.6-2.3-2.32.02.8-2.6-1.31.1-1.11.11.1
Total heroin consumption0.81.02.40.41.00.91.2-1.6-1.51.21.0-1.10.7-0.60.6-0.6-0.6
Bone: trabecular number0.10.20.8-0.30.10.20.1-0.3-0.30.3-0.10.50.9-0.70.7-0.7-0.7
Bone: trabecular spacing0.91.43.70.3-0.6-0.9-0.60.90.9-1.10.2-0.2-1.91.7-1.71.71.7
Bone: trabecular thickness2.23.05.81.12.12.31.9-2.2-2.22.41.2-1.21.6-1.31.3-1.3-1.3
Bone: trabecular tissue density0.50.81.40.41.01.10.7-1.0-1.01.20.5-0.50.8-1.01.0-1.0-1.0
Water consumed over 24 hours0.61.12.7-0.70.10.2-0.3-0.5-0.40.4-0.61.01.6-1.61.6-1.6-1.6
Number of responses in last shaping day0.10.10.4-0.3-0.3-0.3-0.60.50.6-0.3-0.50.50.10.0-0.00.00.0