Alyref

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Alyref	0.32	0.13	0.0e+00	0.24	0.23	0.23	0.24	3.9e-26	1.0e-25	1.7e-25	6.1e-26
2	IL	gene expression	Alyref	0.31	0.16	7.5e-05	0.12	0.08	0.07	0.09	7.7e-04	4.9e-03	1.1e-02	3.9e-03
3	PL	gene expression	Alyref	0.24	0.09	0.0e+00	0.32	0.33	0.33	0.33	2.2e-35	3.4e-37	7.9e-37	9.8e-37
4	Brain	gene expression	Alyref	0.14	0.08	1.3e-12	0.13	0.14	0.14	0.13	4.5e-12	9.8e-13	1.5e-12	2.1e-12
5	NAcc	gene expression	Alyref	0.07	0.04	9.9e-10	0.08	0.08	0.07	0.08	3.5e-09	8.4e-10	1.7e-08	4.2e-09
6	OFC	gene expression	Alyref	0.31	0.15	4.7e-05	0.07	0.04	0.1	0.03	7.8e-03	4.7e-02	1.9e-03	6.4e-02
7	BLA	gene expression	Alyref	0.19	0.09	9.0e-11	0.18	0.18	0.18	0.18	3.6e-10	4.5e-10	1.0e-09	1.0e-09
8	pVTA	gene expression	Alyref	0.1	0.06	1.0e-04	0.1	0.07	0.07	0.08	5.6e-05	4.8e-04	6.7e-04	2.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.2	0.3	0.4	0.6	-0.6	0.6	0.5	0.5	-0.1	-0.6	-0.5
Area under the delay curve	2.0	2.1	2.5	-1.6	1.6	-1.5	-1.5	-1.4	1.3	1.3	1.3
BMI with tail	0.7	2.1	2.7	1.6	-1.6	1.5	1.7	1.5	-0.7	-1.4	-1.5
BMI without tail	7.0	14.4	19.0	3.7	-3.7	3.8	3.9	3.7	-2.5	-4.4	-4.3
Body weight	4.6	19.4	22.9	4.8	-4.8	4.5	4.5	4.5	-3.7	-4.2	-4.2
Weight adjusted by age	3.5	4.0	6.6	2.6	-2.6	1.9	2.1	2.0	-1.6	-1.4	-1.5
Bone surface	0.2	0.4	0.5	0.7	-0.7	0.7	0.6	0.6	-0.7	-0.6	-0.6
Bone volume	0.3	0.5	0.6	0.7	-0.7	0.7	0.7	0.7	-0.5	-0.8	-0.6
Breakpoint value in progressive ratio session	0.4	0.4	0.9	0.6	-0.6	0.6	0.8	0.7	-1.0	-0.2	-0.1
Number of licking bursts	0.1	0.1	0.2	0.5	-0.5	0.4	0.3	0.3	0.0	-0.4	-0.4
Context. condit. distance diff. score	0.6	0.8	1.1	1.0	-1.0	0.9	0.8	0.8	-0.1	-1.0	-1.0
Locomotion velocity, session 1	2.8	3.1	4.0	-2.0	2.0	-1.8	-1.8	-1.7	0.8	1.8	1.8
Locomotion distance, session 1	2.8	3.6	4.7	-1.8	1.8	-1.9	-1.9	-2.0	2.2	1.7	1.7
Locomotion velocity, session 2	5.5	6.5	7.4	-2.7	2.7	-2.6	-2.7	-2.6	1.7	2.5	2.5
Locomotion distance, session 2	0.3	0.4	0.8	-0.6	0.6	-0.7	-0.7	-0.7	0.9	0.4	0.4
Locomotion velocity, session 3	2.3	2.7	3.4	-1.7	1.7	-1.7	-1.6	-1.6	1.3	1.8	1.9
Locomotion distance, session 3	3.9	4.2	4.6	-2.1	2.1	-2.1	-2.0	-2.1	1.8	2.1	2.1
Stereotopy head waving bouts, day 3	0.7	0.8	1.1	-1.0	1.0	-0.9	-1.0	-0.9	0.6	1.0	1.0
Stereotopy head waving duration, day 3	0.4	0.5	0.6	-0.7	0.7	-0.7	-0.7	-0.7	0.5	0.7	0.7
Locomotion velocity, session 7	0.8	0.9	1.2	-0.9	0.9	-1.0	-0.9	-1.0	0.9	1.1	1.1
Locomotion distance, session 7	2.8	3.5	5.5	-1.7	1.7	-1.9	-1.9	-2.0	2.3	1.7	1.7
Stereotopy head waving bouts, day 7	0.2	0.2	0.2	0.5	-0.5	0.5	0.5	0.4	-0.5	-0.3	-0.4
Stereotopy head waving duration, day 7	0.4	0.5	0.9	0.7	-0.7	0.7	0.6	0.7	-0.9	-0.5	-0.5
Locomotion velocity, session 8	0.3	0.3	0.5	-0.6	0.6	-0.6	-0.7	-0.7	0.7	0.3	0.3
Locomotion distance, session 8	0.2	0.3	0.6	0.6	-0.6	0.4	0.4	0.2	0.7	-0.7	-0.7
Degree of sensitization distance	0.8	0.8	1.1	0.9	-0.9	0.9	0.8	0.8	-0.4	-1.0	-1.1
Degree of sensitization stereotypy	0.5	0.6	0.7	0.8	-0.8	0.8	0.8	0.8	-0.8	-0.6	-0.7
Conditioned locomotion	5.2	6.1	7.1	2.6	-2.6	2.5	2.5	2.5	-1.6	-2.6	-2.7
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	0.4	-0.3	-0.1	-0.1	0.2	0.2	0.2
Cocaine response after cond. not corrected	0.6	0.6	1.0	-1.0	1.0	-0.8	-0.7	-0.7	0.6	0.6	0.7
Cocaine response before conditioning	0.8	1.0	1.4	-1.0	1.0	-1.0	-1.2	-1.1	0.8	0.9	1.0
Saline control response	3.7	4.9	5.1	2.2	-2.2	2.3	2.2	2.2	-2.0	-2.2	-2.3
Bone: connectivity density	0.0	0.0	0.1	0.1	-0.1	0.0	-0.1	-0.1	0.3	-0.1	-0.1
Bone: cortical apparent density	3.2	4.3	4.6	-2.1	2.1	-2.1	-2.0	-2.0	2.1	2.1	2.1
Bone: cortical area	7.1	10.7	11.6	3.4	-3.4	3.4	3.4	3.3	-3.2	-3.0	-3.0
Bone: cortical porosity	0.6	0.7	2.3	0.6	-0.6	0.7	0.9	0.9	-1.5	-0.4	-0.4
Bone: cortical porosity	0.9	1.0	2.4	0.9	-0.9	0.9	1.1	1.1	-1.5	-0.6	-0.7
Bone: cortical thickness	5.5	9.0	10.2	3.1	-3.1	3.1	3.1	3.1	-3.2	-2.6	-2.7
Bone: cortical thickness	1.8	2.1	2.6	1.5	-1.5	1.5	1.6	1.6	-1.3	-1.2	-1.3
Bone: cortical tissue density	3.8	5.0	5.3	-2.2	2.2	-2.3	-2.1	-2.2	2.2	2.3	2.3
Condit. Reinf. active minus inactive responses	3.0	3.4	3.6	1.8	-1.8	1.8	1.9	1.8	-1.7	-1.9	-1.9
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.6	1.2	-1.2	1.2	1.3	1.2	-0.9	-1.1	-1.1
Condit. Reinf. active responses	5.3	6.5	7.3	2.5	-2.5	2.6	2.5	2.5	-2.4	-2.7	-2.7
Condit. Reinf. inactive responses	1.5	1.8	2.2	1.2	-1.2	1.3	1.3	1.3	-1.4	-1.5	-1.5
Incentive salience index mean	2.3	2.8	2.9	1.7	-1.7	1.7	1.6	1.6	-1.6	-1.7	-1.7
Condit. Reinf. lever presses	0.0	0.0	0.1	0.2	-0.2	0.1	0.0	0.0	-0.1	-0.1	-0.1
Condit. Reinf. active minus inactive responses	1.2	1.5	2.2	1.2	-1.2	1.2	1.1	1.2	-1.2	-1.4	-1.5
Condit. Reinf. active-inactive response ratio	2.8	2.9	3.7	1.6	-1.6	1.7	1.6	1.7	-1.9	-1.8	-1.8
Condit. Reinf. active responses	0.3	0.5	1.0	0.6	-0.6	0.6	0.6	0.6	-0.4	-0.9	-1.0
Condit. Reinf. inactive responses	0.4	0.5	1.1	-0.7	0.7	-0.8	-0.6	-0.7	1.0	0.6	0.6
Condit. Reinf. lever presses	0.3	0.4	0.6	0.6	-0.6	0.5	0.7	0.6	0.2	-0.7	-0.8
Condit. Reinf. lever reinforcers received	0.3	0.5	0.9	0.6	-0.6	0.6	0.7	0.6	-0.2	-0.9	-1.0
Conditioned reinforcement - actives	0.1	0.1	0.2	0.5	-0.5	0.2	0.0	0.1	0.3	-0.3	-0.1
Conditioned reinforcement - inactives	1.9	2.1	2.8	1.7	-1.7	1.4	1.4	1.4	-1.4	-1.2	-1.3
Conditioned locomotion	0.2	0.2	0.7	0.8	-0.8	0.3	0.2	0.3	-0.1	-0.3	-0.1
Patch foraging indifference point 0 sec	0.1	0.2	0.4	0.6	-0.6	0.4	0.5	0.4	-0.0	-0.1	-0.2
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.2	0.2	-0.0	-0.0	0.0	0.2	-0.3	-0.2
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	0.0	-0.0	-0.2	-0.2	-0.2	0.3	0.3	0.4
Delay disc. indifference point, 16s delay	1.8	1.8	3.9	-1.0	1.0	-1.4	-1.4	-1.4	2.0	1.1	1.2
Delay disc. indifference point, 2s delay	0.4	0.4	0.5	-0.7	0.7	-0.7	-0.7	-0.6	0.2	0.7	0.7
Delay disc. indifference point, 24s delay	6.3	6.1	6.8	-2.5	2.5	-2.5	-2.5	-2.4	2.0	2.6	2.6
Delay disc. indifference point, 4s delay	0.6	0.7	1.3	-1.1	1.1	-0.8	-0.8	-0.8	0.5	0.6	0.5
Delay disc. indifference point, 8s delay	1.1	1.2	1.8	-1.3	1.3	-1.1	-1.0	-1.0	0.6	1.1	1.0
Indifference point function ln k	0.8	1.2	1.5	-0.9	0.9	-1.1	-1.0	-1.1	1.2	1.2	1.1
Indifference point function log k	0.8	1.2	1.5	-0.9	0.9	-1.1	-1.0	-1.1	1.2	1.2	1.1
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	0.6	-0.6	0.4	0.5	0.4	0.1	-0.2	-0.3
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.0	-0.0	0.1	0.2	0.2	-0.1	-0.1	-0.1
Patch foraging total patch changes 18 sec	0.1	0.2	1.1	0.0	-0.0	-0.2	-0.1	-0.2	1.1	0.1	0.1
Patch foraging total patch changes 24 sec	0.7	0.9	1.6	1.2	-1.2	0.9	1.1	1.0	-0.3	-0.6	-0.8
Patch foraging total patch changes 6 sec	0.4	0.6	0.6	0.8	-0.8	0.7	0.8	0.8	-0.7	-0.6	-0.7
Patch foraging time to switch 0 sec	0.5	0.8	0.9	-0.8	0.8	-0.9	-0.9	-0.9	0.7	0.9	0.9
Patch foraging water rate 0 sec	2.8	4.5	5.2	2.3	-2.3	2.1	2.2	2.1	-1.6	-2.2	-2.1
Patch foraging water rate 12 sec	0.3	0.4	0.8	0.7	-0.7	0.6	0.7	0.6	-0.0	-0.8	-0.9
Patch foraging water rate 18 sec	0.8	1.1	1.6	1.3	-1.3	1.0	1.0	0.9	-0.5	-1.1	-1.1
Patch foraging water rate 24 sec	2.5	3.4	4.4	2.1	-2.1	1.8	2.0	1.8	-0.6	-1.9	-2.1
Patch foraging water rate 6 sec	0.2	0.2	0.4	0.6	-0.6	0.4	0.4	0.3	-0.3	-0.5	-0.5
Seeking ratio, delayed vs. immediate footshock	1.7	1.9	2.3	1.2	-1.2	1.5	1.4	1.5	-1.3	-1.4	-1.4
Distance traveled before self-admin	1.3	1.3	2.6	1.1	-1.1	1.2	1.4	1.3	-1.6	-0.6	-0.6
Distance traveled after self-admin	0.6	0.7	0.9	0.9	-0.9	0.9	0.9	0.8	-0.5	-0.8	-0.9
Extensor digitorum longus weight	0.1	0.3	0.4	0.6	-0.6	0.5	0.5	0.4	0.6	-0.7	-0.6
Bone: elastic displacement	1.3	1.5	1.9	1.2	-1.2	1.3	1.4	1.3	-1.1	-1.1	-1.1
Bone: elastic work	7.2	9.3	11.4	2.9	-2.9	3.1	3.3	3.3	-3.4	-2.8	-2.7
Bone: endosteal estimation	0.0	0.1	0.2	0.2	-0.2	0.1	0.2	0.1	0.5	-0.4	-0.3
Bone: endosteal perimeter	0.8	1.6	1.7	1.3	-1.3	1.3	1.3	1.3	-1.3	-1.2	-1.1
Epididymis fat weight	1.2	2.8	3.8	1.9	-1.9	1.8	1.8	1.7	-1.0	-1.6	-1.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.1	-0.4	-0.2	0.3	0.1	0.0
Delta time in open arm before/after self-admin	0.1	0.1	0.1	0.3	-0.3	0.1	0.2	0.1	0.3	0.2	0.2
Diff in mean of infusions in LGA sessions	0.3	0.3	0.9	-0.4	0.4	-0.5	-0.5	-0.5	0.3	0.6	1.0
Delay discount exponential model param	2.9	3.0	3.8	2.0	-2.0	1.8	1.7	1.7	-1.5	-1.6	-1.6
Extinction: sum of active levers before priming	1.8	1.8	3.4	-1.1	1.1	-1.3	-1.2	-1.3	0.9	1.6	1.8
Active lever presses in extinction session 6	0.4	0.3	1.2	-0.1	0.1	-0.5	-0.3	-0.3	-0.1	1.1	1.1
Bone: final force	6.7	10.8	11.6	3.4	-3.4	3.4	3.4	3.4	-3.1	-3.2	-3.1
Bone: final moment	7.6	12.3	13.4	3.6	-3.6	3.6	3.7	3.6	-3.3	-3.4	-3.3
Food consumed during 24 hour testing period	0.6	0.8	1.1	1.0	-1.0	0.8	0.8	0.8	-1.1	-0.7	-0.8
Glucose	3.2	4.9	6.7	-2.6	2.6	-2.3	-2.0	-2.0	0.9	2.4	2.4
Heart weight	0.4	0.6	0.8	0.7	-0.7	0.8	0.9	0.9	-0.6	-0.8	-0.8
Delay discount hyperbolic model param	2.7	2.9	3.7	1.9	-1.9	1.8	1.7	1.7	-1.4	-1.6	-1.5
Intermittent access intake day 1-15 change	1.0	1.0	1.2	0.8	-0.8	1.0	1.0	1.1	-1.0	-1.1	-0.9
Intermittent access intake escalation	0.9	0.9	1.0	0.9	-0.9	0.9	1.0	1.0	-0.9	-1.0	-0.9
Intermittent access intake escalation 2	2.2	2.1	3.3	1.4	-1.4	1.5	1.6	1.6	-1.8	-1.1	-1.0
Intermitt. access day 1 inactive lever presses	1.4	1.5	1.9	1.3	-1.3	1.2	1.3	1.3	-1.4	-0.8	-1.0
Intermitt. access day 15 inactive lever presses	1.5	1.7	2.8	1.7	-1.7	1.2	1.2	1.2	-1.0	-1.0	-1.2
Intermitt. access escalation Index	1.2	1.1	1.8	1.4	-1.4	1.0	0.9	0.9	-0.4	-1.1	-1.1
Intermittent access day 1 total infusions	0.4	0.4	0.9	0.4	-0.4	0.7	0.7	0.7	-0.4	-0.7	-0.9
Intermittent access day 15 total infusions	0.9	1.1	1.3	1.0	-1.0	1.0	1.0	1.0	-0.7	-1.1	-1.2
Intermittent access terminal intake (last 3 days)	1.5	1.7	1.8	1.3	-1.3	1.4	1.3	1.3	-1.1	-1.3	-1.3
Intermittent access total infusions	0.7	0.8	1.2	0.8	-0.8	0.9	0.9	0.9	-0.7	-1.0	-1.1
Intermittent access day 1 locomotion	0.6	0.6	1.0	1.0	-1.0	0.7	0.6	0.7	-0.4	-0.8	-0.8
Intermittent access day 15 total locomotion	0.5	0.5	0.7	0.7	-0.7	0.8	0.7	0.8	-0.8	-0.8	-0.8
Intermittent access total locomotion	0.7	0.8	1.0	1.0	-1.0	0.8	0.8	0.8	-0.8	-0.9	-0.8
Intermittent access standard deviation	0.4	0.4	1.0	-0.6	0.6	-0.5	-0.4	-0.4	-0.2	1.0	0.9
Left kidney weight	0.0	0.1	0.3	0.2	-0.2	0.3	0.1	0.2	-0.5	-0.0	0.0
Right kidney weight	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.3	-0.2	0.2	0.3	0.2
Cocaine induced anxiety	4.4	5.1	8.4	2.1	-2.1	2.3	2.6	2.5	-2.9	-1.6	-1.5
Post-drug Anxiety	0.5	0.5	1.4	0.5	-0.5	0.7	0.9	0.8	-1.2	-0.1	-0.4
Baseline Anxiety	8.2	8.7	10.2	-2.9	2.9	-3.1	-3.2	-3.1	3.1	2.7	2.5
Tail length	7.1	21.5	25.2	4.7	-4.7	4.7	4.5	4.5	-3.9	-5.0	-4.9
Length with tail	2.9	10.8	12.8	3.6	-3.6	3.4	3.2	3.3	-3.3	-3.0	-2.9
Length without tail	0.3	0.7	2.0	-0.4	0.4	-0.6	-0.8	-0.6	-0.1	1.4	1.4
Times rat made contact with spout	1.2	1.4	3.6	1.0	-1.0	1.1	1.1	1.2	-1.9	-0.9	-0.9
Lifetime Intake	0.2	0.2	0.3	0.4	-0.4	0.5	0.4	0.4	-0.4	-0.5	-0.6
Liver weight, left	0.1	0.2	0.4	-0.5	0.5	-0.4	-0.3	-0.3	-0.0	0.6	0.7
Liver weight, right	2.3	3.9	5.2	2.2	-2.2	2.0	1.7	1.8	-2.3	-1.8	-1.6
Locomotor activity	0.8	1.2	1.8	-1.0	1.0	-1.1	-1.0	-1.1	1.1	1.4	1.2
Locomotor testing distance	1.0	1.6	3.1	-0.8	0.8	-1.2	-1.2	-1.2	1.8	1.6	1.3
Locomotor testing rearing	0.3	0.5	1.2	-0.3	0.3	-0.7	-0.6	-0.7	1.1	0.8	0.6
Locomotion in novel chamber	0.2	0.3	0.9	0.0	-0.0	-0.5	-0.5	-0.5	0.9	0.7	0.5
Locomotion in novel chamber post-restriction	2.5	3.0	4.2	1.1	-1.1	1.9	1.8	1.8	-1.8	-2.0	-2.1
Fecal boli incidents, locomotor time 1	0.6	0.7	0.8	-0.8	0.8	-0.9	-0.9	-0.9	0.8	0.7	0.8
Change in fecal boli incidents, locomotor task	2.4	2.3	3.7	-1.9	1.9	-1.4	-1.3	-1.3	0.9	1.6	1.3
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.1	0.4	-0.4	0.8	0.5	0.6	-0.0	-1.0	-1.0
Bouts of movement, locomotor time 1	2.1	2.2	2.5	-1.6	1.6	-1.6	-1.5	-1.5	1.3	1.5	1.4
Total resting periods, locomotor time 1	2.6	2.8	3.6	-1.9	1.9	-1.7	-1.7	-1.7	1.3	1.6	1.6
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.6	0.6	-0.5	-0.4	-0.4	0.0	0.6	0.5
Distance moved, locomotor task time 1	0.6	0.6	0.7	0.8	-0.8	0.9	0.8	0.8	-0.2	-0.9	-0.8
Vertical activity count, locomotor time 1	1.3	1.3	2.1	1.4	-1.4	1.2	1.1	1.1	-0.4	-1.1	-1.1
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.1	0.1	0.1	-0.1	0.0	0.0	-0.2	-0.3
Bouts of movement, locomotor time 2	1.3	1.4	1.7	-1.3	1.3	-1.3	-1.3	-1.3	1.1	1.0	0.8
Total resting periods, locomotor time 2	0.8	0.9	1.1	-1.0	1.0	-1.0	-1.1	-1.0	1.0	0.7	0.5
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.5	0.5	-0.3	-0.4	-0.3	-0.0	0.0	0.1
Distance moved, locomotor task time 2	0.0	0.1	0.1	0.4	-0.4	0.1	0.1	0.1	0.3	-0.0	-0.2
Vertical activity count, locomotor time 2	0.2	0.2	0.5	0.7	-0.7	0.3	0.2	0.2	0.4	-0.3	-0.5
Light reinforcement 1	1.0	1.9	2.6	1.6	-1.6	1.6	1.5	1.4	-0.5	-1.3	-1.3
Light reinforcement 2	2.3	3.0	3.8	1.9	-1.9	1.9	1.8	1.8	-1.5	-1.6	-1.5
Bone: marrow area	0.0	0.1	0.2	0.2	-0.2	0.1	0.1	0.1	0.5	-0.4	-0.3
Bone: maximum diameter	1.7	3.2	3.7	1.9	-1.9	1.9	1.7	1.8	-1.8	-1.6	-1.6
Bone: maximum force	6.8	11.7	12.3	3.4	-3.4	3.5	3.5	3.5	-3.2	-3.5	-3.4
Bone: maximum moment	7.6	13.1	14.1	3.6	-3.6	3.7	3.8	3.7	-3.4	-3.6	-3.5
Mean time between licks in bursts	1.8	2.6	2.9	-1.6	1.6	-1.6	-1.6	-1.6	1.7	1.5	1.6
Mean num. licks in bursts	0.2	0.3	1.2	0.3	-0.3	0.3	0.5	0.5	-1.1	-0.3	-0.2
Cd content in liver	1.9	2.1	2.4	-1.5	1.5	-1.5	-1.4	-1.5	1.4	1.3	1.3
Co content in liver	0.1	0.2	0.3	-0.3	0.3	-0.4	-0.3	-0.4	0.5	0.5	0.5
Cu content in liver	0.3	0.3	1.8	0.4	-0.4	0.4	0.4	0.5	-1.3	-0.2	-0.2
Fe content in liver	1.2	1.4	1.9	-1.0	1.0	-1.2	-1.1	-1.2	1.4	1.2	1.2
K content in liver	2.4	2.4	3.2	1.8	-1.8	1.6	1.5	1.5	-1.2	-1.5	-1.5
Mg content in liver	0.3	0.3	0.4	0.7	-0.7	0.5	0.3	0.3	0.2	-0.6	-0.7
Mn content in liver	0.3	0.4	0.7	0.6	-0.6	0.6	0.5	0.5	-0.8	-0.5	-0.6
Na content in liver	0.0	0.0	0.1	0.2	-0.2	0.0	-0.0	-0.0	-0.1	0.3	0.1
Rb content in liver	1.1	1.3	2.0	1.2	-1.2	1.2	1.1	1.1	-0.6	-1.2	-1.4
Se content in liver	0.4	0.4	0.5	0.7	-0.7	0.7	0.7	0.7	-0.4	-0.7	-0.7
Sr content in liver	0.3	0.2	0.5	-0.5	0.5	-0.4	-0.3	-0.3	-0.1	0.6	0.7
Zn content in liver	0.0	0.1	0.2	-0.1	0.1	-0.2	-0.4	-0.3	-0.3	0.1	0.1
Bone: minimum diameter	3.7	6.8	7.8	2.8	-2.8	2.7	2.7	2.7	-2.6	-2.4	-2.2
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.3	0.3	-0.2	-0.0	-0.0	-0.0	0.0	-0.0
Time in novel zone, hab. session 1	0.0	0.0	0.0	0.2	-0.2	0.1	0.0	0.0	-0.0	-0.1	-0.0
Total zone transitions, hab. session 1	0.3	0.4	0.7	-0.6	0.6	-0.7	-0.6	-0.6	0.8	0.5	0.6
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.5	-0.5	0.3	0.5	0.3	0.1	-0.3	-0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.3	0.6	-0.6	0.4	0.5	0.3	0.1	-0.3	-0.2
Time in familiar zone, hab. session 2	0.2	0.2	0.5	-0.4	0.4	-0.5	-0.3	-0.4	0.7	0.4	0.5
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3	-0.2	0.1	0.1	0.1
Total zone transitions, hab. session 2	0.1	0.2	0.8	-0.3	0.3	-0.4	-0.4	-0.4	0.9	-0.0	-0.0
Total locomotion distance, hab. session 2	0.5	0.6	1.0	0.9	-0.9	0.7	0.7	0.6	-0.0	-1.0	-0.9
Locomotion velocity, hab. session 2	0.8	1.0	1.5	1.2	-1.2	1.0	0.9	0.9	-0.3	-1.2	-1.2
Novel to familiar place preference ratio	3.0	3.1	4.4	1.6	-1.6	1.7	1.9	1.9	-2.1	-1.6	-1.5
Novelty place preference	2.8	2.9	4.4	1.5	-1.5	1.7	1.8	1.8	-2.1	-1.5	-1.5
Time in novel zone, NPP test	2.3	2.4	3.4	1.4	-1.4	1.5	1.6	1.6	-1.9	-1.4	-1.4
Total zone transitions, NPP test	0.3	0.5	2.0	-0.4	0.4	-0.6	-0.7	-0.7	1.4	0.3	0.3
Total locomotion distance, NPP test	0.2	0.2	0.5	0.5	-0.5	0.3	0.2	0.1	0.7	-0.5	-0.5
Locomotion velocity, NPP test	0.2	0.3	0.5	0.7	-0.7	0.5	0.5	0.4	0.4	-0.6	-0.6
Intraocular pressure	0.8	1.1	1.8	0.9	-0.9	1.0	1.1	1.1	-0.7	-1.4	-1.3
Delta distance traveled before/after self-admin	0.3	0.4	1.6	-0.4	0.4	-0.5	-0.6	-0.6	1.3	0.2	0.1
Delta ambulatory time before/after self-admin	1.1	1.2	3.0	-0.9	0.9	-1.1	-1.2	-1.2	1.7	0.7	0.6
Parametrial fat weight	2.0	3.8	4.3	2.1	-2.1	2.0	2.0	2.0	-1.6	-2.1	-1.8
Pavlov. Cond. lever latency	0.8	1.0	3.6	-0.8	0.8	-0.9	-0.7	-0.9	1.9	0.6	0.6
Pavlov. Cond. magazine entry latency	2.3	2.9	5.5	1.5	-1.5	1.7	1.8	1.8	-2.3	-1.5	-1.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.2	-0.2	0.3	0.4	0.4	-0.9	-0.0	-0.0
Pavlov. Cond. index score	3.1	4.0	6.8	1.9	-1.9	2.0	1.9	2.0	-2.6	-1.7	-1.7
Pavlov. Cond. latency score	2.3	3.0	6.4	1.6	-1.6	1.7	1.6	1.7	-2.5	-1.4	-1.4
Pavlov. Cond. lever contacts	0.6	0.8	2.1	0.8	-0.8	0.9	0.7	0.8	-1.4	-0.6	-0.6
Pavlov. Cond. magazine entry number	1.8	2.2	5.1	-1.2	1.2	-1.4	-1.5	-1.6	2.2	1.2	1.2
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.8	0.7	-0.7	0.6	0.6	0.6	0.0	-0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	3.3	4.1	6.6	2.0	-2.0	2.0	2.0	2.1	-2.6	-1.7	-1.7
Pavlov. Cond. response bias	1.8	2.2	4.8	1.3	-1.3	1.4	1.5	1.5	-2.2	-1.2	-1.2
Pavlov. Cond. lever latency	0.7	0.9	1.2	-1.1	1.1	-0.9	-1.1	-0.9	0.0	1.0	1.1
Pavlov. Cond. magazine entry latency	1.6	1.9	3.8	-1.2	1.2	-1.4	-1.3	-1.4	1.9	1.2	1.2
Pavlov. Cond. change in total contacts	0.2	0.2	1.4	-0.1	0.1	-0.3	-0.1	-0.3	1.2	0.3	0.2
Pavlov. Cond. index score	0.1	0.2	1.2	-0.0	0.0	-0.3	-0.0	-0.2	1.1	0.2	0.2
Pavlov. Cond. latency score	0.1	0.1	1.0	0.1	-0.1	-0.2	0.0	-0.1	1.0	0.1	0.0
Pavlov. Cond. lever contacts	1.0	1.4	1.8	1.3	-1.3	1.2	1.3	1.1	-0.1	-1.3	-1.3
Pavlov. Cond. magazine entry number	1.1	1.3	3.6	0.9	-0.9	1.1	1.0	1.1	-1.9	-1.1	-1.0
Pavlov. Cond. intertrial magazine entries	2.2	2.8	3.7	1.6	-1.6	1.7	1.6	1.7	-1.5	-1.9	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.6	-0.2	0.2	-0.4	-0.2	-0.4	1.3	0.3	0.3
Pavlov. Cond. response bias	0.2	0.2	0.3	0.5	-0.5	0.3	0.4	0.3	0.6	-0.4	-0.5
Time in closed arm before self-admin	0.3	0.3	0.9	-0.9	0.9	-0.3	-0.2	-0.2	-0.2	0.3	0.4
Time in closed arm after self-admin	0.8	0.8	1.5	-1.2	1.2	-0.8	-0.9	-0.7	0.0	0.9	0.9
Time in open arm before self-admin	0.1	0.1	0.3	0.2	-0.2	-0.3	-0.5	-0.4	0.5	0.2	0.2
Time in open arm after self-admin	0.1	0.1	0.5	0.0	-0.0	-0.3	-0.3	-0.4	0.7	0.4	0.3
Bone: periosteal estimation	2.4	4.9	5.5	2.4	-2.4	2.3	2.3	2.2	-1.8	-2.2	-2.1
Bone: periosteal perimeter	3.4	5.6	7.8	2.3	-2.3	2.4	2.4	2.4	-2.8	-2.1	-2.0
Bone: post-yield work	0.0	0.0	0.1	0.0	-0.0	-0.0	-0.1	-0.1	0.3	-0.2	-0.2
Progressive ratio test 1 active lever presses	1.4	1.5	1.7	1.2	-1.2	1.3	1.2	1.2	-1.0	-1.3	-1.2
Progressive ratio test 1 breakpoint	1.8	1.9	2.2	1.3	-1.3	1.5	1.4	1.4	-1.1	-1.5	-1.4
Progressive ratio test 1 inactive lever presses	3.2	3.6	4.4	2.1	-2.1	1.9	1.9	1.9	-1.4	-1.9	-1.8
Progressive ratio test 2 active lever presses	0.5	0.5	0.8	0.6	-0.6	0.7	0.7	0.7	-0.7	-0.8	-0.9
Progressive ratio test 2 breakpoint	0.6	0.7	1.1	0.8	-0.8	0.8	0.8	0.8	-0.6	-1.0	-1.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.6	0.8	-0.8	0.8	0.8	0.8	-0.8	-0.6	-0.8
Incentive Sensitization - Responses	0.2	0.2	0.6	0.2	-0.2	0.5	0.5	0.5	-0.3	-0.6	-0.8
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.2	-0.2	0.4	0.4	0.4	-0.2	-0.5	-0.6
Sum of active levers in priming session hrs 5-6	0.7	0.7	1.3	0.6	-0.6	0.8	1.2	1.0	-1.1	-0.6	-0.6
Progressive ratio	0.5	0.5	0.7	-0.7	0.7	-0.8	-0.8	-0.8	0.5	0.8	0.7
Food seeking constrained by brief footshock	0.2	0.3	0.5	-0.7	0.7	-0.5	-0.4	-0.4	-0.2	0.5	0.7
Seeking ratio, punishment vs. effort	0.1	0.2	0.3	0.4	-0.4	0.5	0.5	0.5	-0.3	-0.5	-0.4
Retroperitoneal fat weight	5.2	17.1	20.0	4.5	-4.5	4.3	4.4	4.2	-3.2	-4.0	-3.8
Reaction time number correct	0.4	0.6	2.4	0.8	-0.8	0.3	0.3	0.2	1.5	-0.7	-0.7
Reaction time mean minus median	0.1	0.1	0.4	-0.3	0.3	-0.3	-0.4	-0.3	-0.1	0.5	0.6
Reaction time mean minus median AUC	0.0	0.0	0.0	0.2	-0.2	0.0	-0.1	-0.0	-0.2	0.0	0.2
Reaction time num false alarms	0.2	0.3	0.4	-0.5	0.5	-0.6	-0.5	-0.6	0.6	0.6	0.5
Reaction time num false alarms AUC	0.6	0.9	1.1	-0.8	0.8	-1.0	-0.9	-1.0	1.1	0.9	0.9
Reaction time trials correct on left	0.4	0.6	2.4	0.8	-0.8	0.3	0.3	0.2	1.5	-0.7	-0.7
Reaction time trials on left	0.4	0.6	2.5	0.9	-0.9	0.3	0.3	0.2	1.6	-0.7	-0.7
Reaction time mean	0.2	0.3	0.5	0.7	-0.7	0.6	0.7	0.6	-0.1	-0.6	-0.5
Reaction time mean AUC	0.2	0.3	0.6	0.8	-0.8	0.6	0.6	0.5	0.3	-0.5	-0.4
Median of all reaction times	0.3	0.4	0.6	0.7	-0.7	0.7	0.7	0.7	0.0	-0.7	-0.5
Reaction time omissions	0.2	0.3	0.8	0.9	-0.9	0.4	0.4	0.3	0.2	-0.1	-0.2
Reaction time false alarm rate	0.7	1.0	1.3	-1.1	1.1	-1.0	-1.0	-0.9	0.1	1.2	1.1
Reaction time premature initiation rate	1.4	1.9	2.3	-1.5	1.5	-1.5	-1.3	-1.3	1.1	1.4	1.2
Reaction time premature initiations	0.8	1.2	3.3	-0.9	0.9	-1.1	-1.0	-1.1	1.8	0.8	0.7
Std. dev. reaction times	0.3	0.4	0.7	-0.5	0.5	-0.6	-0.6	-0.7	0.9	0.7	0.8
Reaction time trials completed	0.4	0.6	2.5	0.9	-0.9	0.3	0.3	0.2	1.6	-0.7	-0.7
Reaction time trials AUC	0.5	0.7	2.4	0.9	-0.9	0.4	0.4	0.2	1.5	-0.7	-0.7
Run reversals in cocaine runway, females	0.8	0.7	2.0	-0.8	0.8	-0.7	-0.7	-0.8	1.4	0.8	0.7
Run reversals in cocaine runway, males	1.2	1.2	2.7	0.9	-0.9	1.1	1.1	1.2	-1.6	-0.8	-0.9
Latency to leave start box in cocaine runway	0.3	0.3	0.5	-0.6	0.6	-0.5	-0.5	-0.6	0.7	0.2	0.1
Latency to leave start box in cocaine runway, F	0.3	0.3	1.2	-0.3	0.3	-0.5	-0.6	-0.6	1.1	0.3	0.1
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.2	0.2	0.2	0.2	0.2	-0.4	-0.4	-0.4
Std. dev. time between licks in bursts	0.7	0.8	1.2	1.1	-1.1	0.9	0.8	0.7	0.4	-1.0	-1.1
Total sessions with >9 infusions	0.2	0.2	0.4	-0.4	0.4	-0.5	-0.6	-0.6	0.5	0.4	0.4
Short access day 1 total inactive lever presses	0.1	0.1	0.3	0.5	-0.5	-0.0	-0.2	-0.1	0.4	-0.0	-0.3
Short access day 10 total inactive lever presses	3.9	4.3	5.2	1.9	-1.9	2.1	2.2	2.2	-2.2	-1.9	-2.3
Short access day 1 total infusions	1.9	2.0	2.5	-1.3	1.3	-1.4	-1.5	-1.5	1.3	1.5	1.6
Short access day 10 total infusions	0.7	0.7	1.0	0.7	-0.7	0.9	0.8	0.9	-1.0	-1.0	-0.9
Short access total infusions	0.0	0.0	0.0	-0.1	0.1	0.0	-0.0	-0.0	-0.1	-0.0	-0.0
Short access day 1 locomotion	0.5	0.6	0.8	-0.8	0.8	-0.7	-0.8	-0.8	0.4	0.8	0.9
Short access day 10 total locomotion	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.3	-0.2	-0.3	0.5	0.6
Short access total locomotion	0.4	0.5	0.6	-0.8	0.8	-0.7	-0.8	-0.7	0.1	0.7	0.7
One hour access (0.3 mA shock)	1.8	2.1	2.7	1.4	-1.4	1.5	1.4	1.4	-1.1	-1.6	-1.6
Compulsive drug intake	0.6	0.6	0.9	0.9	-0.9	0.7	0.8	0.8	-0.4	-0.8	-0.6
One hour access (shock baseline)	0.2	0.3	0.5	0.6	-0.6	0.5	0.3	0.4	-0.3	-0.6	-0.7
Social response proportion	0.4	0.4	0.7	-0.4	0.4	-0.7	-0.7	-0.7	0.8	0.5	0.7
Social responses	0.1	0.1	0.3	-0.0	0.0	-0.3	-0.4	-0.4	0.4	0.5	0.6
Social time	0.1	0.1	0.4	-0.3	0.3	-0.3	-0.3	-0.4	0.6	0.4	0.3
Soleus weight	1.6	4.7	5.3	2.3	-2.3	2.2	2.1	2.1	-2.0	-2.2	-2.1
Bone: stiffness	1.0	1.5	1.9	1.3	-1.3	1.2	1.2	1.2	-1.1	-1.4	-1.3
Tibialis anterior weight	0.0	0.1	0.3	0.3	-0.3	0.3	0.2	0.2	-0.2	-0.6	-0.4
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.2	-0.2	0.3	0.2	0.2	-0.3	-0.4	-0.3
Time to tail flick, vehicle, after self-admin	2.6	2.8	3.4	-1.7	1.7	-1.7	-1.8	-1.8	1.4	1.5	1.6
Time to tail flick, test, before self-admin	0.1	0.1	0.5	0.1	-0.1	0.2	0.2	0.3	-0.7	-0.4	-0.6
Time to tail flick, test, after self-admin	0.3	0.3	0.7	-0.1	0.1	-0.6	-0.6	-0.6	0.4	0.8	0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.6	-0.3	0.3	-0.6	-0.7	-0.7	0.8	0.5	0.4
Delta time to tail flick, test, before/after SA	0.8	0.7	1.3	-0.6	0.6	-0.8	-0.8	-0.8	0.8	1.1	1.1
Tibia length	9.9	27.8	30.3	5.3	-5.3	5.4	5.3	5.4	-5.5	-5.0	-5.1
Ambulatory time before self-admin	2.6	2.7	4.1	1.6	-1.6	1.7	1.9	1.8	-2.0	-1.1	-1.1
Ambulatory time after self-admin	0.4	0.4	0.6	0.7	-0.7	0.7	0.7	0.7	-0.4	-0.5	-0.6
Bone: tissue strength	1.6	1.6	1.9	1.3	-1.3	1.3	1.3	1.2	-0.8	-1.4	-1.3
Total heroin consumption	0.1	0.2	0.5	0.3	-0.3	0.1	0.3	0.2	-0.6	0.5	0.7
Bone: trabecular number	0.0	0.0	0.0	0.1	-0.1	0.1	0.0	0.1	0.0	-0.1	-0.1
Bone: trabecular spacing	0.3	0.4	0.5	0.7	-0.7	0.5	0.6	0.4	0.6	-0.7	-0.7
Bone: trabecular thickness	0.3	0.4	1.5	0.4	-0.4	0.5	0.6	0.7	-1.2	-0.5	-0.3
Bone: trabecular tissue density	1.0	1.4	1.5	-1.2	1.2	-1.2	-1.2	-1.2	1.1	1.1	1.2
Water consumed over 24 hours	0.1	0.1	0.5	-0.2	0.2	-0.2	-0.2	-0.2	-0.7	0.3	0.4
Number of responses in last shaping day	1.2	1.3	2.7	1.6	-1.6	1.1	1.0	1.0	-0.7	-0.7	-0.7