Hub : Genes

Alyref

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Alyref 0.34 0.17 7.9e-06 0.15 0.13 0.16 0.12 1.6e-04 5.4e-04 1.2e-04 1.0e-03
2 Adipose gene expression Alyref 0.29 0.12 0.0e+00 0.23 0.22 0.22 0.23 5.9e-25 2.5e-24 1.1e-23 7.4e-25
3 Adipose mRNA stability Alyref 0.07 0.06 7.3e-06 0.06 0.04 0.04 0.05 6.7e-07 3.5e-05 1.6e-05 2.9e-06
4 Liver mRNA stability Alyref 0.13 0.1 3.0e-05 0.05 0.04 0.03 0.05 5.8e-06 1.3e-05 1.0e-04 7.2e-06
5 NAcc gene expression Alyref 0.05 0.03 4.4e-10 0.07 0.07 0.06 0.07 4.3e-11 1.3e-10 5.0e-10 1.5e-10
6 PL gene expression Alyref 0.21 0.09 0.0e+00 0.28 0.28 0.28 0.28 9.5e-31 7.4e-31 2.5e-30 1.4e-30
7 Brain gene expression Alyref 0.15 0.08 1.5e-14 0.15 0.16 0.15 0.16 2.9e-14 7.9e-15 4.3e-14 1.6e-14
8 pVTA gene expression Alyref 0.09 0.05 1.0e-07 0.06 0.09 0.09 0.09 1.5e-05 6.6e-08 1.1e-07 1.9e-07
9 OFC gene expression Alyref 0.33 0.15 1.4e-05 0.08 0.05 0.15 0.1 5.7e-03 2.6e-02 2.0e-04 1.9e-03
10 IC gene expression Alyref 0.16 0.1 2.3e-04 0.06 0.07 0.07 0.08 1.7e-03 6.9e-04 8.1e-04 2.1e-04
11 BLA gene expression Alyref 0.15 0.08 3.7e-08 0.16 0.15 0.14 0.15 8.7e-09 3.6e-08 7.8e-08 3.3e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.20.30.50.6-0.6-0.6-0.60.70.60.60.40.30.70.6
Area under the delay curve1.82.12.7-1.41.51.51.5-1.6-1.5-1.5-1.5-1.2-1.2-1.3
BMI with tail0.62.24.61.5-1.5-1.5-1.51.61.41.61.10.42.11.2
BMI without tail3.29.711.73.2-3.2-3.2-3.23.33.13.32.72.33.43.2
Body weight3.314.616.54.0-4.1-4.1-4.14.03.93.93.73.13.53.6
Weight adjusted by age2.94.37.02.1-2.6-2.6-2.61.82.02.11.90.22.11.6
Bone surface0.20.30.90.6-0.5-0.5-0.50.60.60.50.60.90.00.6
Bone volume0.20.40.60.7-0.6-0.6-0.60.80.70.70.60.70.50.7
Breakpoint value in progressive ratio session0.50.71.10.6-0.8-0.8-0.80.60.81.01.10.90.80.4
Number of licking bursts0.10.10.10.3-0.3-0.3-0.30.30.30.20.20.30.10.4
Context. condit. distance diff. score0.81.03.60.8-1.0-1.0-1.01.00.80.90.3-0.41.90.9
Locomotion velocity, session 12.93.15.2-1.81.91.91.9-2.0-1.7-1.8-1.3-0.7-2.3-1.7
Locomotion distance, session 12.73.54.6-2.11.81.81.8-1.8-1.9-1.9-2.2-2.0-1.0-1.7
Locomotion velocity, session 25.86.78.0-2.82.72.72.7-2.7-2.6-2.7-2.4-1.6-2.8-2.5
Locomotion distance, session 20.30.50.9-0.80.70.70.7-0.7-0.7-0.7-0.9-0.8-0.1-0.5
Locomotion velocity, session 32.22.53.1-1.61.71.71.7-1.6-1.6-1.6-1.4-1.0-1.7-1.7
Locomotion distance, session 34.04.34.9-2.22.12.12.1-2.1-2.2-2.1-2.1-2.0-1.6-2.2
Stereotopy head waving bouts, day 30.70.81.6-0.90.90.90.9-0.9-0.9-0.9-0.7-0.3-1.3-1.0
Stereotopy head waving duration, day 30.50.60.9-0.80.70.70.7-0.8-0.8-0.8-0.7-0.5-1.0-0.9
Locomotion velocity, session 70.80.91.6-1.00.90.90.9-0.8-1.0-0.9-1.0-1.3-0.5-1.1
Locomotion distance, session 72.83.57.0-2.11.71.71.7-1.7-1.9-1.8-2.3-2.6-0.5-1.7
Stereotopy head waving bouts, day 70.30.30.50.6-0.6-0.6-0.60.70.60.60.60.40.60.5
Stereotopy head waving duration, day 70.30.40.60.7-0.7-0.7-0.70.70.70.60.70.60.30.5
Locomotion velocity, session 80.40.51.0-0.80.70.70.7-0.6-0.7-0.7-1.0-1.00.2-0.4
Locomotion distance, session 80.50.74.00.2-0.6-0.6-0.60.60.30.4-0.4-1.02.00.7
Degree of sensitization distance0.80.81.70.8-0.9-0.9-0.90.90.90.90.60.31.31.1
Degree of sensitization stereotypy0.50.61.00.8-0.8-0.8-0.80.80.70.80.60.31.00.7
Conditioned locomotion4.85.66.82.5-2.5-2.5-2.52.62.42.42.01.42.62.5
Cocaine response after cond. corrected0.10.10.2-0.20.40.40.4-0.4-0.2-0.1-0.1-0.0-0.1-0.3
Cocaine response after cond. not corrected0.60.71.1-0.81.01.01.0-1.0-0.8-0.7-0.7-0.3-0.7-0.7
Cocaine response before conditioning0.81.01.4-1.10.90.90.9-1.0-1.1-1.1-1.2-0.8-0.9-0.9
Saline control response3.14.14.72.2-2.1-2.1-2.12.12.12.01.91.81.72.1
Bone: connectivity density0.00.00.0-0.1-0.0-0.0-0.00.2-0.0-0.1-0.20.00.10.2
Bone: cortical apparent density3.24.45.4-2.22.12.12.1-2.2-2.2-2.1-2.1-2.1-1.6-2.3
Bone: cortical area6.19.411.73.4-3.1-3.1-3.13.23.23.23.22.92.22.8
Bone: cortical porosity0.70.83.20.9-0.6-0.6-0.60.60.70.71.21.8-0.30.6
Bone: cortical porosity1.31.43.81.3-1.0-1.0-1.01.01.11.11.51.90.21.0
Bone: cortical thickness4.88.010.53.2-2.8-2.8-2.82.93.02.93.23.01.72.5
Bone: cortical thickness1.31.52.01.4-1.2-1.2-1.21.21.31.41.41.01.11.0
Bone: cortical tissue density3.64.95.9-2.32.22.22.2-2.3-2.3-2.2-2.2-2.2-1.8-2.4
Condit. Reinf. active minus inactive responses2.93.23.71.9-1.8-1.8-1.81.91.81.91.71.51.81.9
Condit. Reinf. active-inactive response ratio1.31.41.81.2-1.2-1.2-1.21.31.21.21.10.71.31.1
Condit. Reinf. active responses5.06.27.22.6-2.5-2.5-2.52.72.62.62.42.22.32.7
Condit. Reinf. inactive responses1.21.52.01.2-1.1-1.1-1.11.31.21.21.21.41.11.4
Incentive salience index mean2.22.73.31.7-1.7-1.7-1.71.81.71.71.61.41.61.7
Condit. Reinf. lever presses0.00.10.20.1-0.2-0.2-0.20.30.20.1-0.0-0.20.40.1
Condit. Reinf. active minus inactive responses0.50.71.10.8-0.9-0.9-0.90.80.80.80.81.00.71.0
Condit. Reinf. active-inactive response ratio2.02.34.11.6-1.5-1.5-1.51.41.61.51.72.00.71.6
Condit. Reinf. active responses0.10.10.40.2-0.3-0.3-0.30.20.20.30.10.20.70.5
Condit. Reinf. inactive responses0.70.91.9-1.10.90.90.9-0.9-1.0-0.8-1.2-1.40.0-0.8
Condit. Reinf. lever presses0.30.52.10.4-0.6-0.6-0.60.60.50.70.2-0.31.40.7
Condit. Reinf. lever reinforcers received0.20.21.30.2-0.4-0.4-0.40.30.30.40.1-0.11.10.6
Conditioned reinforcement - actives0.10.11.0-0.10.00.00.0-0.1-0.3-0.3-0.4-1.0-0.0-0.2
Conditioned reinforcement - inactives0.60.91.90.9-1.4-1.4-1.40.50.80.80.7-0.10.90.5
Conditioned locomotion0.10.10.30.4-0.5-0.5-0.50.00.00.1-0.1-0.30.30.1
Patch foraging indifference point 0 sec0.10.20.30.4-0.6-0.6-0.60.40.40.50.3-0.00.50.2
Patch foraging indifference point AUC0.00.00.10.00.00.00.00.20.10.10.00.20.30.3
Delay disc. indifference point, 0s delay0.10.11.10.1-0.3-0.3-0.3-0.1-0.00.0-0.1-1.10.2-0.2
Delay disc. indifference point, 16s delay1.31.42.8-1.20.90.90.9-1.3-1.4-1.2-1.7-1.7-0.1-1.0
Delay disc. indifference point, 2s delay0.50.61.4-0.60.60.60.6-1.0-0.7-0.7-0.7-1.2-0.5-0.8
Delay disc. indifference point, 24s delay5.56.27.7-2.62.52.52.5-2.8-2.6-2.6-2.3-1.6-2.4-2.6
Delay disc. indifference point, 4s delay0.60.61.0-0.71.01.01.0-0.8-0.6-0.6-0.5-0.1-1.0-0.5
Delay disc. indifference point, 8s delay1.01.21.8-1.01.21.21.2-1.3-1.0-1.1-0.8-0.5-1.3-1.0
Indifference point function ln k0.61.11.6-1.10.90.90.9-1.1-1.1-1.1-1.2-1.3-0.6-1.2
Indifference point function log k0.61.11.6-1.10.90.90.9-1.1-1.1-1.1-1.2-1.3-0.6-1.2
Patch foraging total patch changes 0 sec0.10.30.60.4-0.6-0.6-0.60.50.40.50.3-0.10.70.3
Patch foraging total patch changes 12 sec0.10.10.60.1-0.1-0.1-0.10.20.30.30.40.80.00.3
Patch foraging total patch changes 18 sec0.10.10.6-0.2-0.0-0.0-0.00.0-0.10.0-0.4-0.70.80.1
Patch foraging total patch changes 24 sec0.81.42.51.2-1.4-1.4-1.41.01.11.21.00.01.60.8
Patch foraging total patch changes 6 sec0.40.60.90.7-0.8-0.8-0.80.70.80.80.90.90.30.6
Patch foraging time to switch 0 sec0.40.80.9-0.90.90.90.9-0.9-0.9-1.0-0.9-0.6-0.9-0.9
Patch foraging water rate 0 sec2.14.56.42.1-2.3-2.3-2.32.12.12.21.81.12.52.1
Patch foraging water rate 12 sec0.30.61.90.7-0.8-0.8-0.80.70.60.80.30.01.41.0
Patch foraging water rate 18 sec0.81.32.51.1-1.3-1.3-1.31.21.01.10.60.21.61.2
Patch foraging water rate 24 sec2.94.19.81.9-2.2-2.2-2.22.01.82.11.20.13.12.0
Patch foraging water rate 6 sec0.20.20.50.3-0.6-0.6-0.60.40.40.40.20.20.70.5
Seeking ratio, delayed vs. immediate footshock1.31.62.51.4-1.1-1.1-1.11.61.41.41.30.51.31.4
Distance traveled before self-admin1.11.41.81.1-1.3-1.3-1.31.11.31.31.30.81.10.7
Distance traveled after self-admin1.01.32.71.1-1.2-1.2-1.21.21.11.20.80.31.60.9
Extensor digitorum longus weight0.20.63.00.5-0.7-0.7-0.70.70.50.70.0-0.61.70.9
Bone: elastic displacement1.41.72.21.5-1.3-1.3-1.31.41.31.41.41.20.81.2
Bone: elastic work7.19.312.73.4-2.9-2.9-2.93.13.23.23.63.61.72.8
Bone: endosteal estimation0.00.10.5-0.1-0.1-0.1-0.10.1-0.00.0-0.3-0.40.70.4
Bone: endosteal perimeter0.71.51.81.3-1.3-1.3-1.31.31.31.21.31.30.81.2
Epididymis fat weight1.65.67.92.5-2.5-2.5-2.52.72.32.51.91.32.82.2
Delta time in closed arm before/after self-admin0.10.10.2-0.2-0.2-0.2-0.2-0.0-0.2-0.3-0.4-0.5-0.20.1
Delta time in open arm before/after self-admin0.10.10.50.0-0.2-0.2-0.20.0-0.1-0.0-0.2-0.70.5-0.4
Diff in mean of infusions in LGA sessions0.10.10.20.3-0.4-0.4-0.40.30.40.40.50.10.40.3
Delay discount exponential model param2.83.13.91.8-1.9-1.9-1.92.01.81.81.71.21.61.6
Extinction: sum of active levers before priming0.50.50.8-0.70.70.70.7-0.7-0.8-0.7-0.7-0.7-0.7-0.9
Active lever presses in extinction session 60.40.41.5-0.80.50.50.5-1.0-0.6-0.5-0.2-0.1-0.6-1.2
Bone: final force6.810.812.73.6-3.3-3.3-3.33.33.43.43.33.02.83.3
Bone: final moment7.812.514.93.9-3.6-3.6-3.63.63.63.73.63.32.93.5
Food consumed during 24 hour testing period0.50.70.90.9-0.9-0.9-0.90.90.80.90.70.61.00.7
Glucose7.311.517.8-3.43.73.73.7-3.8-3.3-3.3-2.3-1.3-4.2-3.6
Heart weight0.71.11.51.1-0.9-0.9-0.90.91.11.21.21.20.91.0
Delay discount hyperbolic model param2.52.83.71.7-1.8-1.8-1.81.91.71.71.61.11.61.6
Intermittent access intake day 1-15 change0.30.61.60.9-0.4-0.4-0.40.70.90.91.11.30.30.8
Intermittent access intake escalation0.30.61.50.9-0.4-0.4-0.40.70.80.81.01.20.30.7
Intermittent access intake escalation 21.31.42.91.4-1.0-1.0-1.01.11.41.41.71.30.70.9
Intermitt. access day 1 inactive lever presses1.24.45.92.0-2.1-2.1-2.12.02.02.11.72.42.32.1
Intermitt. access day 15 inactive lever presses0.71.52.81.3-1.6-1.6-1.61.01.11.10.7-0.11.70.9
Intermitt. access escalation Index0.40.50.90.8-0.8-0.8-0.80.70.70.70.5-0.01.00.7
Intermittent access day 1 total infusions0.00.10.20.4-0.3-0.3-0.30.40.30.30.2-0.00.20.2
Intermittent access day 15 total infusions0.40.71.21.1-0.8-0.8-0.80.80.90.90.80.40.70.8
Intermittent access terminal intake (last 3 days)0.71.01.51.2-1.0-1.0-1.01.01.11.11.10.40.80.9
Intermittent access total infusions0.20.30.60.8-0.5-0.5-0.50.50.60.60.5-0.00.40.5
Intermittent access day 1 locomotion0.10.10.20.3-0.5-0.5-0.50.10.10.1-0.0-0.20.2-0.0
Intermittent access day 15 total locomotion0.40.71.31.0-0.7-0.7-0.70.70.80.80.91.10.40.8
Intermittent access total locomotion0.30.40.70.7-0.7-0.7-0.70.40.50.50.50.80.40.5
Intermittent access standard deviation0.20.41.1-0.40.70.70.7-0.7-0.5-0.5-0.1-0.0-0.9-1.0
Left kidney weight0.00.10.90.2-0.1-0.1-0.10.20.20.10.41.0-0.50.1
Right kidney weight0.00.10.40.0-0.0-0.0-0.00.10.1-0.10.20.6-0.6-0.2
Cocaine induced anxiety0.71.02.31.1-1.0-1.0-1.00.41.11.11.51.10.50.3
Post-drug Anxiety0.20.20.6-0.10.30.30.3-0.7-0.00.00.50.7-0.5-0.8
Baseline Anxiety2.22.63.4-1.71.81.81.8-1.5-1.6-1.6-1.5-0.9-1.6-1.5
Tail length4.115.917.64.2-4.2-4.2-4.24.04.14.03.93.83.04.1
Length with tail2.08.810.83.1-3.2-3.2-3.22.83.12.93.33.31.52.7
Length without tail0.20.71.70.9-0.9-0.9-0.90.40.80.71.31.0-0.30.1
Times rat made contact with spout1.01.12.91.1-0.9-0.9-0.90.81.11.01.41.70.20.9
Lifetime Intake0.00.00.20.4-0.2-0.2-0.20.10.20.20.1-0.30.10.1
Liver weight, left0.71.11.8-1.11.01.01.0-1.0-1.0-1.1-0.9-0.6-1.3-1.2
Liver weight, right3.05.37.52.4-2.7-2.7-2.72.32.32.22.01.81.82.0
Locomotor activity0.71.11.9-1.30.90.90.9-1.1-1.1-1.1-1.1-1.0-0.7-1.4
Locomotor testing distance1.22.14.6-1.61.01.01.0-1.4-1.6-1.5-1.8-2.2-0.5-1.8
Locomotor testing rearing0.30.62.0-0.80.30.30.3-0.8-0.9-0.7-1.1-1.40.0-0.9
Locomotion in novel chamber0.20.31.6-0.3-0.2-0.2-0.2-0.4-0.5-0.5-0.7-1.30.0-0.7
Locomotion in novel chamber post-restriction2.74.38.72.2-1.5-1.5-1.52.32.32.22.33.01.22.4
Fecal boli incidents, locomotor time 10.30.40.7-0.60.60.60.6-0.5-0.7-0.7-0.8-0.5-0.4-0.5
Change in fecal boli incidents, locomotor task2.32.33.6-1.51.71.71.7-1.6-1.3-1.3-0.8-1.0-1.9-1.6
Time >=10cm from walls, locomotor time 10.60.61.50.7-0.4-0.4-0.41.00.80.60.51.20.61.1
Bouts of movement, locomotor time 11.82.12.5-1.61.61.61.6-1.5-1.5-1.4-1.4-0.7-1.4-1.3
Total resting periods, locomotor time 12.52.73.6-1.81.91.91.9-1.7-1.6-1.6-1.4-0.7-1.8-1.6
Rest time, locomotor task time 10.50.71.4-0.90.90.90.9-1.0-0.7-0.7-0.50.1-1.2-0.9
Distance moved, locomotor task time 10.40.60.80.9-0.8-0.8-0.80.70.80.80.60.00.90.8
Vertical activity count, locomotor time 10.71.62.71.4-1.4-1.4-1.41.21.21.20.90.11.61.2
Time >=10cm from walls, locomotor time 20.10.10.50.10.20.20.20.10.1-0.10.20.4-0.70.3
Bouts of movement, locomotor time 20.81.21.5-1.11.21.21.2-1.2-1.2-1.2-1.2-0.5-1.0-0.9
Total resting periods, locomotor time 20.40.61.0-0.70.80.80.8-0.8-0.9-0.9-1.0-0.4-0.7-0.5
Rest time, locomotor task time 20.10.20.4-0.30.50.50.5-0.2-0.3-0.3-0.20.7-0.6-0.0
Distance moved, locomotor task time 20.10.10.50.1-0.3-0.3-0.3-0.10.10.10.0-0.70.10.0
Vertical activity count, locomotor time 20.10.20.30.1-0.6-0.6-0.60.30.20.2-0.1-0.40.60.2
Light reinforcement 11.02.44.41.6-1.6-1.6-1.61.91.51.51.00.12.11.5
Light reinforcement 22.23.44.52.1-1.9-1.9-1.92.11.91.81.61.11.81.8
Bone: marrow area0.00.10.6-0.1-0.1-0.1-0.10.1-0.10.0-0.3-0.40.70.4
Bone: maximum diameter1.52.83.31.8-1.8-1.8-1.81.81.81.61.81.80.91.4
Bone: maximum force6.311.212.83.6-3.4-3.4-3.43.43.43.53.43.22.83.4
Bone: maximum moment7.112.514.43.8-3.5-3.5-3.53.63.63.73.63.42.93.6
Mean time between licks in bursts0.92.32.6-1.61.51.51.5-1.6-1.6-1.6-1.6-1.3-1.3-1.4
Mean num. licks in bursts0.10.20.40.4-0.4-0.4-0.40.30.40.50.70.50.30.3
Cd content in liver0.40.40.9-0.80.60.60.6-0.6-0.6-0.5-0.9-0.90.6-0.1
Co content in liver0.00.00.10.2-0.2-0.2-0.20.20.10.10.10.20.00.0
Cu content in liver0.91.12.51.1-0.9-0.9-0.90.91.01.01.21.60.30.9
Fe content in liver0.40.51.6-0.70.50.50.5-0.6-0.7-0.6-0.9-1.30.1-0.7
K content in liver1.71.62.21.3-1.5-1.5-1.51.41.21.20.80.41.51.3
Mg content in liver0.40.51.20.5-0.8-0.8-0.80.80.50.5-0.0-0.31.10.8
Mn content in liver0.10.10.20.3-0.4-0.4-0.40.30.30.20.20.4-0.10.2
Na content in liver0.10.10.50.0-0.2-0.2-0.20.1-0.0-0.0-0.2-0.70.3-0.1
Rb content in liver2.12.44.21.5-1.6-1.6-1.61.71.61.61.20.92.11.6
Se content in liver0.40.50.90.7-0.9-0.9-0.90.70.60.70.50.11.00.6
Sr content in liver0.30.20.9-0.40.40.40.4-0.6-0.4-0.5-0.10.1-0.9-0.6
Zn content in liver1.71.92.81.4-1.4-1.4-1.41.41.41.31.31.70.81.7
Bone: minimum diameter3.97.18.32.9-2.8-2.8-2.82.82.72.72.72.52.12.4
Time in familiar zone, hab. session 10.00.00.1-0.10.20.20.2-0.2-0.1-0.00.0-0.0-0.1-0.1
Time in novel zone, hab. session 10.00.00.00.0-0.2-0.2-0.20.20.10.0-0.0-0.00.20.1
Total zone transitions, hab. session 10.30.41.1-0.60.60.60.6-0.6-0.6-0.5-0.8-1.10.2-0.5
Total locomotion distance, hab. session 10.20.41.80.3-0.5-0.5-0.50.50.30.50.0-0.71.30.2
Locomotion velocity, hab. session 10.30.41.80.4-0.6-0.6-0.60.50.30.50.0-0.71.30.2
Time in familiar zone, hab. session 20.30.31.0-0.60.50.50.5-0.5-0.6-0.4-0.7-1.00.2-0.5
Time in novel zone, hab. session 20.10.10.3-0.10.20.20.2-0.1-0.1-0.2-0.10.3-0.6-0.0
Total zone transitions, hab. session 20.20.20.7-0.40.20.20.2-0.2-0.3-0.2-0.8-0.80.80.1
Total locomotion distance, hab. session 20.60.82.80.6-0.9-0.9-0.90.80.70.70.1-0.31.70.9
Locomotion velocity, hab. session 20.91.23.30.9-1.2-1.2-1.21.10.91.00.40.01.81.1
Novel to familiar place preference ratio2.83.14.11.9-1.7-1.7-1.71.61.81.92.02.01.21.7
Novelty place preference2.72.93.91.9-1.6-1.6-1.61.61.71.82.02.01.11.6
Time in novel zone, NPP test2.22.43.21.7-1.5-1.5-1.51.51.61.61.81.71.11.5
Total zone transitions, NPP test0.30.52.1-0.70.30.30.3-0.3-0.6-0.5-1.1-1.40.7-0.2
Total locomotion distance, NPP test0.40.52.70.2-0.6-0.6-0.60.50.20.3-0.4-1.11.60.4
Locomotion velocity, NPP test0.40.62.80.4-0.8-0.8-0.80.70.50.6-0.1-0.91.70.6
Intraocular pressure1.01.42.31.2-1.0-1.0-1.01.11.11.21.01.31.31.5
Delta distance traveled before/after self-admin0.20.20.8-0.40.40.40.4-0.2-0.4-0.4-0.7-0.90.2-0.4
Delta ambulatory time before/after self-admin0.91.11.8-1.01.11.11.1-0.9-1.1-1.1-1.3-1.2-0.5-0.8
Parametrial fat weight0.71.72.21.4-1.4-1.4-1.41.31.21.21.01.01.31.5
Pavlov. Cond. lever latency0.91.13.9-1.10.80.80.8-0.8-1.0-0.7-1.5-2.00.8-0.6
Pavlov. Cond. magazine entry latency1.92.54.51.8-1.4-1.4-1.41.51.71.62.02.10.61.4
Pavlov. Cond. change in total contacts0.20.20.80.5-0.1-0.1-0.10.20.40.40.70.9-0.30.1
Pavlov. Cond. index score3.03.86.12.2-1.8-1.8-1.82.02.01.92.42.50.71.7
Pavlov. Cond. latency score2.32.85.91.9-1.5-1.5-1.51.61.81.62.12.40.21.4
Pavlov. Cond. lever contacts0.70.92.31.0-0.8-0.8-0.80.90.90.71.21.5-0.20.6
Pavlov. Cond. magazine entry number1.92.45.3-1.81.21.21.2-1.4-1.6-1.5-2.1-2.3-0.3-1.3
Pavlov. Cond. intertrial magazine entries0.40.41.30.6-0.7-0.7-0.70.70.60.60.3-0.01.10.8
Pavlov. Cond. lever-magazine prob. diff.2.93.65.52.1-1.8-1.8-1.81.92.01.92.32.30.81.7
Pavlov. Cond. response bias1.51.84.41.5-1.1-1.1-1.11.21.41.31.92.10.01.1
Pavlov. Cond. lever latency1.21.64.4-1.11.31.31.3-1.3-1.1-1.3-0.7-0.0-2.1-1.3
Pavlov. Cond. magazine entry latency1.51.84.0-1.51.21.21.2-1.2-1.4-1.2-1.8-2.00.0-1.1
Pavlov. Cond. change in total contacts0.20.31.6-0.40.20.20.2-0.2-0.3-0.1-0.7-1.31.1-0.1
Pavlov. Cond. index score0.20.31.4-0.30.00.00.0-0.1-0.20.0-0.6-1.21.2-0.0
Pavlov. Cond. latency score0.20.31.4-0.3-0.0-0.0-0.0-0.0-0.20.0-0.6-1.21.20.0
Pavlov. Cond. lever contacts0.91.24.00.9-1.1-1.1-1.11.10.91.10.5-0.22.01.2
Pavlov. Cond. magazine entry number0.91.23.51.2-0.9-0.9-0.90.91.10.91.41.9-0.30.9
Pavlov. Cond. intertrial magazine entries1.62.53.11.7-1.6-1.6-1.61.51.61.61.51.51.41.8
Pavlov. Cond. lever-magazine prob. diff.0.30.41.9-0.50.30.30.3-0.3-0.5-0.2-0.8-1.41.0-0.3
Pavlov. Cond. response bias0.20.31.80.1-0.3-0.3-0.30.30.10.3-0.2-0.81.30.4
Time in closed arm before self-admin0.50.61.3-0.61.11.11.1-0.6-0.6-0.6-0.20.4-1.1-0.6
Time in closed arm after self-admin1.31.43.4-1.21.41.41.4-1.1-1.0-1.1-0.60.4-1.9-0.9
Time in open arm before self-admin0.20.20.40.3-0.6-0.6-0.60.20.20.1-0.1-0.60.40.4
Time in open arm after self-admin0.10.10.60.1-0.3-0.3-0.30.20.00.1-0.2-0.70.8-0.0
Bone: periosteal estimation1.93.94.52.1-2.1-2.1-2.12.12.02.01.91.71.81.9
Bone: periosteal perimeter3.35.79.42.6-2.3-2.3-2.32.42.52.32.83.10.82.1
Bone: post-yield work0.00.00.1-0.20.10.10.1-0.1-0.1-0.1-0.2-0.20.10.0
Progressive ratio test 1 active lever presses0.40.40.70.8-0.7-0.7-0.70.70.70.70.60.30.70.5
Progressive ratio test 1 breakpoint0.40.50.80.9-0.8-0.8-0.80.80.80.80.70.40.70.6
Progressive ratio test 1 inactive lever presses3.44.96.12.2-2.4-2.4-2.42.32.12.21.71.72.52.1
Progressive ratio test 2 active lever presses0.30.31.00.6-0.3-0.3-0.30.50.50.50.51.00.40.6
Progressive ratio test 2 breakpoint0.30.31.10.6-0.4-0.4-0.40.50.50.60.51.00.40.7
Progressive ratio test 2 inactive lever presses0.20.30.50.7-0.6-0.6-0.60.40.60.60.60.50.50.4
Incentive Sensitization - Responses0.20.32.10.4-0.2-0.2-0.20.40.50.50.51.40.30.7
Incentive Sensitization - Breakpoint0.20.32.00.3-0.2-0.2-0.20.40.40.40.41.40.20.7
Sum of active levers in priming session hrs 5-60.50.41.10.4-0.4-0.4-0.40.40.70.90.90.71.00.4
Progressive ratio0.81.21.4-1.21.11.11.1-1.2-1.2-1.2-1.1-1.0-1.0-1.0
Food seeking constrained by brief footshock0.20.30.5-0.40.70.70.7-0.5-0.4-0.4-0.2-0.1-0.6-0.5
Seeking ratio, punishment vs. effort0.10.20.40.6-0.3-0.3-0.30.50.40.50.40.30.60.4
Retroperitoneal fat weight3.916.821.64.4-4.5-4.5-4.54.34.04.23.52.24.63.9
Reaction time number correct0.51.15.10.3-0.9-0.9-0.90.80.30.5-0.5-1.52.30.7
Reaction time mean minus median0.10.20.8-0.30.40.40.4-0.4-0.4-0.5-0.1-0.4-0.9-0.7
Reaction time mean minus median AUC0.00.00.30.1-0.1-0.1-0.1-0.1-0.0-0.20.1-0.2-0.6-0.2
Reaction time num false alarms0.20.30.3-0.50.50.50.5-0.5-0.6-0.5-0.6-0.4-0.4-0.5
Reaction time num false alarms AUC0.40.70.9-0.80.70.70.7-0.9-0.9-0.9-0.9-0.8-0.6-0.8
Reaction time trials correct on left0.51.15.10.3-0.9-0.9-0.90.80.30.5-0.5-1.52.30.7
Reaction time trials on left0.61.15.20.4-0.9-0.9-0.90.80.30.5-0.6-1.62.30.7
Reaction time mean0.30.40.70.7-0.7-0.7-0.70.80.60.60.5-0.10.80.5
Reaction time mean AUC0.30.40.90.7-0.8-0.8-0.80.80.50.50.3-0.41.00.4
Median of all reaction times0.50.71.40.9-0.9-0.9-0.90.90.70.80.5-0.11.20.7
Reaction time omissions0.30.51.00.5-1.0-1.0-1.00.60.40.50.2-0.60.80.2
Reaction time false alarm rate0.81.12.8-0.91.11.11.1-1.1-1.0-1.0-0.60.1-1.7-1.1
Reaction time premature initiation rate1.62.22.9-1.61.61.61.6-1.7-1.6-1.5-1.5-1.1-0.9-1.5
Reaction time premature initiations0.71.22.9-1.20.90.90.9-1.1-1.1-1.0-1.5-1.70.5-0.9
Std. dev. reaction times0.20.41.2-0.60.50.50.5-0.6-0.6-0.6-0.7-1.1-0.4-0.8
Reaction time trials completed0.61.15.20.4-0.9-0.9-0.90.80.30.5-0.6-1.62.30.7
Reaction time trials AUC0.61.15.40.4-1.0-1.0-1.00.80.40.5-0.5-1.62.30.7
Run reversals in cocaine runway, females0.80.81.1-0.81.11.11.1-0.7-0.9-0.8-1.1-0.8-0.1-0.9
Run reversals in cocaine runway, males1.21.22.31.1-1.0-1.0-1.01.11.31.21.51.20.50.9
Latency to leave start box in cocaine runway0.40.50.8-0.50.90.90.9-0.6-0.7-0.7-0.8-0.6-0.6-0.5
Latency to leave start box in cocaine runway, F0.30.31.1-0.30.40.40.4-0.3-0.6-0.5-0.9-1.00.2-0.2
Latency to leave start box in cocaine runway, M0.20.20.7-0.20.70.70.7-0.3-0.2-0.20.00.5-0.8-0.2
Std. dev. time between licks in bursts0.70.93.20.7-0.9-0.9-0.91.10.60.7-0.0-0.61.81.0
Total sessions with >9 infusions0.30.41.6-0.40.30.30.3-0.6-0.6-0.6-0.7-1.3-0.6-0.8
Short access day 1 total inactive lever presses0.10.20.40.2-0.5-0.5-0.50.1-0.00.0-0.3-0.70.5-0.0
Short access day 10 total inactive lever presses1.84.34.82.0-2.1-2.1-2.12.12.12.21.92.12.02.1
Short access day 1 total infusions1.62.14.1-1.31.31.31.3-1.3-1.5-1.5-1.5-2.0-1.2-1.6
Short access day 10 total infusions1.01.21.61.3-1.1-1.1-1.11.11.21.21.21.20.81.0
Short access total infusions0.10.10.50.1-0.1-0.1-0.1-0.2-0.1-0.1-0.2-0.70.0-0.4
Short access day 1 locomotion0.30.40.9-0.40.70.70.7-0.5-0.5-0.6-0.4-0.5-0.9-0.8
Short access day 10 total locomotion0.10.20.9-0.30.20.20.2-0.5-0.2-0.30.10.1-1.0-0.7
Short access total locomotion0.10.10.50.10.00.00.0-0.3-0.1-0.10.20.0-0.7-0.5
One hour access (0.3 mA shock)0.30.30.60.8-0.4-0.4-0.40.70.50.60.40.60.60.8
Compulsive drug intake0.91.12.30.9-1.1-1.1-1.11.10.90.90.50.81.51.2
One hour access (shock baseline)0.00.00.10.3-0.0-0.0-0.00.10.10.00.1-0.3-0.20.1
Social response proportion0.30.31.2-0.60.20.20.2-0.8-0.6-0.5-0.7-1.10.0-0.6
Social responses0.10.20.9-0.30.10.10.1-0.2-0.3-0.3-0.5-0.9-0.0-0.5
Social time0.10.10.4-0.20.20.20.2-0.1-0.2-0.2-0.4-0.60.1-0.3
Soleus weight1.64.65.42.3-2.2-2.2-2.22.12.22.12.12.21.52.2
Bone: stiffness0.71.11.41.1-1.1-1.1-1.11.01.11.11.01.11.01.2
Tibialis anterior weight0.00.00.20.1-0.2-0.2-0.20.10.10.1-0.00.10.20.4
Time to tail flick, vehicle, before self-admin0.30.30.5-0.50.70.70.7-0.5-0.5-0.6-0.5-0.4-0.7-0.4
Time to tail flick, vehicle, after self-admin1.82.43.2-1.51.41.41.4-1.7-1.7-1.8-1.7-1.5-1.6-1.5
Time to tail flick, test, before self-admin0.40.40.7-0.50.80.80.8-0.9-0.5-0.5-0.30.2-0.8-0.3
Time to tail flick, test, after self-admin1.21.32.4-1.21.01.01.0-1.4-1.1-1.1-0.8-0.8-1.5-1.3
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.0-0.4-0.4-0.4-0.1-0.1-0.1-0.3-0.60.3-0.0
Delta time to tail flick, test, before/after SA0.50.50.9-0.70.50.50.5-0.7-0.6-0.7-0.4-0.8-0.9-0.9
Tibia length10.328.538.85.9-5.2-5.2-5.25.35.55.35.86.23.05.3
Ambulatory time before self-admin2.43.64.31.9-2.1-2.1-2.11.92.02.12.01.41.81.5
Ambulatory time after self-admin0.70.81.70.9-1.0-1.0-1.01.00.91.00.60.21.30.6
Bone: tissue strength2.72.73.31.7-1.8-1.8-1.81.81.61.61.41.21.61.8
Total heroin consumption0.10.10.30.1-0.4-0.4-0.4-0.10.20.30.3-0.30.5-0.5
Bone: trabecular number0.00.00.10.1-0.0-0.0-0.00.10.10.00.20.3-0.30.1
Bone: trabecular spacing0.70.94.50.5-0.8-0.8-0.80.80.50.7-0.2-1.02.10.8
Bone: trabecular thickness0.50.72.90.9-0.5-0.5-0.50.50.70.71.21.7-0.40.5
Bone: trabecular tissue density0.91.41.6-1.31.21.21.2-1.2-1.2-1.2-1.2-1.0-0.9-1.0
Water consumed over 24 hours0.10.20.8-0.20.30.30.3-0.4-0.2-0.30.10.6-0.9-0.4
Number of responses in last shaping day0.20.20.90.2-0.5-0.5-0.5-0.2-0.1-0.1-0.2-0.9-0.1-0.5