Hub : Genes

Als2cl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL intron excision ratio chr8_119746568_119746853 0.37 0.22 5.7e-07 0.05 0.06 0.06 0.05 3.8e-06 4.5e-07 5.7e-07 1.8e-06
2 NAcc gene expression Als2cl 0.02 0.02 1.1e-03 0.02 0.02 0.01 0.02 1.6e-03 6.0e-04 4.9e-03 1.7e-03
3 PL gene expression Als2cl 0.03 0.03 4.6e-03 0.01 0.02 0.02 0.01 7.2e-03 3.8e-03 5.9e-03 7.7e-03
4 NAcc intron excision ratio chr8_119746568_119746853 0.02 0.02 3.6e-04 0.02 0.02 0.02 0.02 9.1e-04 3.8e-04 1.2e-03 1.1e-03
5 Brain intron excision ratio chr8_119746114_119746853 0.13 0.14 1.7e-04 0.02 0.04 0.02 0.03 2.3e-03 1.1e-04 7.9e-03 9.9e-04
6 PL intron excision ratio chr8_119746114_119746853 0.03 0.03 9.0e-04 0.03 0.02 0.02 0.02 8.0e-04 1.4e-03 6.0e-03 1.6e-03
7 Adipose gene expression Als2cl 0.24 0.14 1.7e-03 0 0.01 0 -0 1.2e-01 1.8e-02 2.4e-01 5.1e-01
8 Brain gene expression Als2cl 0.59 0.19 7.0e-09 0.08 0.11 0.11 0.09 5.9e-08 2.2e-10 3.9e-10 5.2e-09
9 Liver gene expression Als2cl 0.55 0.17 7.0e-14 0.07 0.13 0.12 0.09 2.8e-08 2.8e-14 3.2e-13 1.4e-10
10 Adipose alternative polyA XM_039082659.2 0.04 0.04 5.5e-04 0.03 0.02 0.03 0.03 4.9e-04 9.1e-04 2.5e-04 5.1e-04
11 pVTA intron excision ratio chr8_119746114_119746853 0.08 0.08 2.5e-05 0.05 0.05 0.06 0.05 4.6e-05 6.7e-05 2.9e-05 1.0e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.00.00.20.00.00.10.1-0.0-0.1-0.00.10.1-0.5-0.0
Area under the delay curve1.41.72.2-1.5-1.5-1.5-1.51.51.4-1.2-1.4-1.1-0.70.8
BMI with tail0.30.95.00.30.60.50.5-1.0-0.52.2-0.1-1.2-0.9-0.6
BMI without tail0.41.44.11.41.31.31.2-1.3-1.12.00.40.1-0.2-1.0
Body weight4.218.331.64.44.94.84.8-5.1-4.75.63.62.31.0-3.6
Weight adjusted by age0.00.10.7-0.00.00.00.0-0.1-0.0-0.00.10.10.90.1
Bone surface0.10.20.4-0.4-0.4-0.4-0.40.40.5-0.0-0.6-0.6-0.20.4
Bone volume0.00.10.1-0.3-0.2-0.2-0.20.20.20.1-0.3-0.4-0.00.2
Breakpoint value in progressive ratio session0.10.10.2-0.3-0.4-0.4-0.40.40.2-0.4-0.3-0.2-0.5-0.2
Number of licking bursts0.10.20.4-0.6-0.4-0.4-0.40.30.4-0.5-0.1-0.3-0.40.2
Context. condit. distance diff. score0.10.10.8-0.10.00.00.0-0.1-0.00.2-0.0-0.2-0.90.1
Locomotion velocity, session 10.20.20.7-0.4-0.3-0.3-0.30.00.20.3-0.2-0.7-0.80.2
Locomotion distance, session 10.81.03.90.91.01.01.0-1.3-0.92.00.4-0.3-0.4-0.7
Locomotion velocity, session 20.40.51.5-0.6-0.6-0.6-0.70.40.70.2-0.9-1.2-0.70.4
Locomotion distance, session 20.30.41.8-0.3-0.1-0.1-0.2-0.30.11.2-0.5-1.3-1.00.0
Locomotion velocity, session 30.30.31.30.50.30.30.3-0.3-0.11.1-0.4-0.5-0.8-0.3
Locomotion distance, session 31.11.12.8-0.8-0.9-0.9-1.00.81.00.2-1.4-1.5-1.70.6
Stereotopy head waving bouts, day 30.10.21.4-0.10.10.10.2-0.2-0.20.00.40.21.2-0.1
Stereotopy head waving duration, day 30.30.40.90.30.50.50.6-0.6-0.60.01.00.80.8-0.3
Locomotion velocity, session 70.30.40.50.70.70.70.7-0.6-0.70.60.60.5-0.6-0.3
Locomotion distance, session 70.40.62.4-0.7-0.7-0.7-0.70.60.6-0.3-0.6-0.7-1.50.6
Stereotopy head waving bouts, day 70.10.10.40.1-0.2-0.2-0.20.50.4-0.5-0.40.10.60.1
Stereotopy head waving duration, day 70.10.20.50.70.40.40.4-0.3-0.30.30.10.40.3-0.4
Locomotion velocity, session 80.40.52.30.50.50.50.5-0.7-0.41.5-0.1-0.6-1.0-0.6
Locomotion distance, session 80.60.93.50.40.50.50.4-0.8-0.41.9-0.2-1.0-1.8-0.3
Degree of sensitization distance1.31.42.41.11.21.21.3-1.1-1.40.31.61.60.9-0.7
Degree of sensitization stereotypy0.10.10.40.5-0.0-0.0-0.10.40.3-0.5-0.40.40.6-0.1
Conditioned locomotion2.73.14.3-1.7-2.0-2.0-2.02.11.9-2.0-1.7-1.2-0.31.6
Cocaine response after cond. corrected0.20.20.30.50.50.50.5-0.5-0.50.30.50.50.5-0.3
Cocaine response after cond. not corrected1.31.52.01.31.41.41.4-1.4-1.31.31.21.00.9-1.0
Cocaine response before conditioning0.91.12.71.11.21.21.1-1.3-1.11.60.70.3-0.0-1.0
Saline control response0.91.24.01.01.01.01.0-0.9-1.10.31.21.42.0-0.4
Bone: connectivity density0.30.51.2-0.7-0.7-0.7-0.70.80.7-1.1-0.4-0.1-0.80.6
Bone: cortical apparent density0.20.30.5-0.4-0.6-0.6-0.60.70.6-0.6-0.7-0.4-0.40.3
Bone: cortical area0.10.21.0-0.6-0.4-0.4-0.40.20.3-0.1-0.1-0.51.00.4
Bone: cortical porosity0.10.20.8-0.4-0.3-0.3-0.30.40.3-0.90.00.3-0.20.2
Bone: cortical porosity0.10.10.8-0.4-0.2-0.2-0.20.30.1-0.90.30.4-0.30.1
Bone: cortical thickness0.20.42.90.20.40.40.4-0.5-0.40.40.40.21.7-0.3
Bone: cortical thickness0.00.00.0-0.00.00.00.0-0.1-0.10.00.20.0-0.00.0
Bone: cortical tissue density0.20.30.5-0.3-0.6-0.6-0.60.70.6-0.6-0.7-0.3-0.40.3
Condit. Reinf. active minus inactive responses0.20.20.90.40.40.40.4-0.2-0.4-0.40.60.90.4-0.1
Condit. Reinf. active-inactive response ratio0.40.41.20.60.60.60.6-0.4-0.7-0.20.91.10.6-0.2
Condit. Reinf. active responses0.10.10.50.1-0.1-0.1-0.10.40.2-0.7-0.10.50.10.0
Condit. Reinf. inactive responses0.60.71.5-0.6-0.9-0.9-0.91.11.0-0.8-1.2-0.7-0.30.3
Incentive salience index mean0.00.00.1-0.2-0.2-0.2-0.20.20.2-0.3-0.1-0.0-0.30.2
Condit. Reinf. lever presses1.21.72.6-1.4-1.4-1.4-1.41.21.4-0.6-1.4-1.6-1.31.0
Condit. Reinf. active minus inactive responses1.62.03.21.41.51.51.5-1.6-1.51.81.10.61.7-1.0
Condit. Reinf. active-inactive response ratio1.31.52.41.51.31.31.3-1.3-1.11.60.80.61.4-0.9
Condit. Reinf. active responses1.41.94.41.31.41.41.4-1.5-1.41.41.20.82.1-1.0
Condit. Reinf. inactive responses0.10.10.3-0.5-0.3-0.3-0.30.20.1-0.40.1-0.20.40.1
Condit. Reinf. lever presses1.82.54.41.81.81.81.8-1.8-1.72.11.20.80.9-1.3
Condit. Reinf. lever reinforcers received1.72.44.21.41.61.61.6-1.7-1.61.61.40.92.0-1.1
Conditioned reinforcement - actives1.62.87.6-2.8-1.6-1.6-1.61.01.0-0.6-0.8-2.1-2.70.6
Conditioned reinforcement - inactives1.42.03.8-2.0-1.6-1.6-1.61.41.4-1.1-1.2-1.5-0.80.9
Conditioned locomotion0.40.51.6-1.2-0.7-0.7-0.60.30.4-0.1-0.3-1.0-1.30.2
Patch foraging indifference point 0 sec0.81.52.61.01.41.31.4-1.5-1.41.11.61.0-1.0-0.7
Patch foraging indifference point AUC0.00.00.20.10.10.10.1-0.1-0.10.2-0.20.00.5-0.4
Delay disc. indifference point, 0s delay0.00.00.1-0.4-0.0-0.00.0-0.1-0.20.10.1-0.10.1-0.3
Delay disc. indifference point, 16s delay0.80.91.2-1.0-1.1-1.1-1.11.01.1-0.8-1.0-0.8-0.30.8
Delay disc. indifference point, 2s delay0.30.30.5-0.7-0.6-0.6-0.60.60.5-0.5-0.6-0.4-0.50.0
Delay disc. indifference point, 24s delay0.91.01.3-1.0-1.0-1.0-1.01.11.1-0.9-1.0-0.8-1.00.7
Delay disc. indifference point, 4s delay1.51.62.1-1.4-1.4-1.4-1.41.51.4-1.2-1.4-1.0-0.50.8
Delay disc. indifference point, 8s delay1.61.92.4-1.6-1.5-1.5-1.51.51.5-1.3-1.4-1.2-0.90.9
Indifference point function ln k0.30.41.9-0.5-0.5-0.5-0.60.20.50.6-0.7-1.4-0.60.7
Indifference point function log k0.30.41.9-0.5-0.5-0.5-0.60.20.50.6-0.7-1.4-0.60.7
Patch foraging total patch changes 0 sec0.91.73.20.91.41.41.4-1.6-1.51.21.81.0-0.8-0.7
Patch foraging total patch changes 12 sec0.60.81.11.01.11.11.1-1.0-0.90.71.01.0-0.4-0.4
Patch foraging total patch changes 18 sec2.03.16.01.01.91.91.9-2.0-2.21.22.51.60.1-1.7
Patch foraging total patch changes 24 sec1.72.94.01.71.91.91.9-2.0-1.91.81.71.3-0.3-1.3
Patch foraging total patch changes 6 sec0.10.10.30.50.40.40.4-0.3-0.30.10.40.5-0.5-0.0
Patch foraging time to switch 0 sec0.20.30.9-0.4-0.6-0.6-0.60.70.6-0.9-0.5-0.0-0.70.3
Patch foraging water rate 0 sec0.20.51.00.10.60.60.6-0.9-0.80.90.80.11.0-0.2
Patch foraging water rate 12 sec0.20.51.10.90.70.70.7-0.8-0.71.00.40.10.9-0.1
Patch foraging water rate 18 sec0.10.21.20.50.30.30.3-0.4-0.11.1-0.2-0.40.50.3
Patch foraging water rate 24 sec0.71.02.31.11.01.01.0-0.9-1.10.70.80.91.5-0.7
Patch foraging water rate 6 sec0.40.61.41.00.80.80.8-0.9-0.81.20.50.30.8-0.2
Seeking ratio, delayed vs. immediate footshock1.51.83.6-1.9-1.6-1.6-1.51.41.3-1.2-1.1-1.30.20.9
Distance traveled before self-admin0.20.20.4-0.6-0.5-0.5-0.50.40.3-0.4-0.4-0.4-0.60.4
Distance traveled after self-admin0.10.20.7-0.3-0.4-0.4-0.40.40.4-0.3-0.4-0.30.20.8
Extensor digitorum longus weight0.20.61.3-0.9-0.8-0.8-0.80.60.7-0.3-0.6-1.0-1.20.7
Bone: elastic displacement0.10.10.20.10.20.20.2-0.3-0.30.00.50.30.5-0.2
Bone: elastic work0.40.51.40.60.70.70.7-0.9-0.71.20.50.00.5-0.6
Bone: endosteal estimation0.10.20.80.20.40.40.4-0.5-0.50.30.60.3-0.9-0.2
Bone: endosteal perimeter1.02.12.8-1.6-1.6-1.6-1.61.31.5-0.9-1.3-1.7-1.51.3
Epididymis fat weight0.31.01.80.81.11.11.1-1.0-1.10.81.01.00.4-1.3
Delta time in closed arm before/after self-admin0.30.30.4-0.5-0.6-0.6-0.60.60.5-0.5-0.6-0.6-0.40.4
Delta time in open arm before/after self-admin0.30.30.60.80.70.70.6-0.6-0.40.50.50.6-0.3-0.2
Diff in mean of infusions in LGA sessions0.00.00.2-0.00.00.00.0-0.0-0.1-0.00.1-0.0-0.0-0.5
Delay discount exponential model param1.61.82.41.51.51.51.5-1.6-1.51.31.51.10.7-0.8
Extinction: sum of active levers before priming0.20.21.3-0.5-0.1-0.1-0.0-0.1-0.2-0.00.2-0.1-1.2-0.4
Active lever presses in extinction session 60.20.20.60.10.30.30.4-0.4-0.60.30.50.2-0.4-0.8
Bone: final force0.91.42.31.21.31.31.3-1.4-1.31.51.10.60.8-0.9
Bone: final moment1.11.72.91.31.41.41.4-1.6-1.41.71.20.60.9-1.0
Food consumed during 24 hour testing period1.21.72.31.31.41.41.4-1.5-1.51.51.20.71.1-0.9
Glucose0.71.11.71.31.21.21.2-1.2-1.11.30.80.7-0.4-0.9
Heart weight1.42.23.41.21.71.61.7-1.9-1.71.81.60.80.3-1.3
Delay discount hyperbolic model param1.92.12.71.61.61.61.6-1.6-1.61.41.51.20.7-0.9
Intermittent access intake day 1-15 change0.61.22.9-1.5-1.1-1.1-1.10.80.9-0.6-0.7-1.2-1.70.6
Intermittent access intake escalation0.81.63.0-1.7-1.3-1.3-1.31.11.1-0.8-0.9-1.3-1.70.7
Intermittent access intake escalation 20.20.21.0-0.7-0.4-0.4-0.30.20.2-0.1-0.1-0.5-1.00.1
Intermitt. access day 1 inactive lever presses0.00.10.2-0.2-0.4-0.4-0.40.40.4-0.3-0.5-0.40.30.3
Intermitt. access day 15 inactive lever presses1.02.13.7-1.1-1.5-1.5-1.51.61.5-1.3-1.5-1.11.91.1
Intermitt. access escalation Index0.00.00.0-0.1-0.1-0.1-0.10.00.10.0-0.1-0.20.10.1
Intermittent access day 1 total infusions0.20.30.8-0.9-0.6-0.6-0.60.30.4-0.2-0.3-0.7-0.10.3
Intermittent access day 15 total infusions1.21.84.0-2.0-1.4-1.4-1.41.11.2-0.8-0.9-1.6-1.70.8
Intermittent access terminal intake (last 3 days)1.01.33.0-1.7-1.2-1.2-1.20.80.9-0.6-0.7-1.4-1.70.6
Intermittent access total infusions1.41.74.0-2.0-1.4-1.4-1.41.01.1-0.6-0.9-1.7-1.40.8
Intermittent access day 1 locomotion0.10.10.20.30.30.30.3-0.4-0.30.40.30.10.5-0.2
Intermittent access day 15 total locomotion0.30.62.7-0.9-0.6-0.6-0.60.30.5-0.2-0.3-0.9-1.60.4
Intermittent access total locomotion0.81.02.6-1.4-1.0-1.0-1.00.70.8-0.4-0.6-1.2-1.60.6
Intermittent access standard deviation0.00.00.2-0.00.00.00.0-0.1-0.00.10.1-0.1-0.5-0.0
Left kidney weight0.52.44.01.81.81.81.8-1.7-1.52.01.10.90.8-1.5
Right kidney weight0.21.12.30.81.21.21.2-1.3-1.21.50.90.30.1-1.1
Cocaine induced anxiety0.00.00.1-0.00.10.10.1-0.1-0.20.10.20.10.1-0.3
Post-drug Anxiety0.00.00.1-0.3-0.2-0.2-0.20.20.1-0.2-0.2-0.1-0.1-0.0
Baseline Anxiety0.10.10.1-0.1-0.3-0.3-0.30.30.3-0.3-0.3-0.20.10.3
Tail length4.015.720.64.54.54.54.5-4.0-4.33.23.84.02.2-3.3
Length with tail7.331.941.06.26.46.46.4-6.1-6.25.45.44.93.2-4.8
Length without tail6.219.827.04.45.15.05.0-5.2-5.05.04.43.02.0-3.7
Times rat made contact with spout0.30.30.50.70.60.60.6-0.5-0.60.30.60.70.3-0.4
Lifetime Intake1.61.93.9-2.0-1.5-1.5-1.51.11.2-0.7-1.0-1.7-1.70.9
Liver weight, left0.61.02.61.11.01.01.0-0.7-1.00.40.81.21.6-0.9
Liver weight, right1.32.23.01.71.71.71.7-1.5-1.71.41.31.41.2-1.2
Locomotor activity5.07.911.02.93.23.23.2-3.3-3.23.03.02.1-0.2-2.0
Locomotor testing distance4.27.710.92.83.13.13.1-3.3-3.23.03.02.00.1-2.1
Locomotor testing rearing0.20.51.30.20.60.60.6-0.8-0.80.41.10.5-0.9-0.3
Locomotion in novel chamber0.10.20.7-0.9-0.4-0.4-0.40.20.3-0.1-0.1-0.60.30.2
Locomotion in novel chamber post-restriction0.40.71.20.60.90.90.9-0.9-1.10.80.90.6-0.7-0.9
Fecal boli incidents, locomotor time 10.30.40.50.60.70.70.7-0.7-0.70.60.60.50.6-0.7
Change in fecal boli incidents, locomotor task0.00.00.3-0.1-0.0-0.0-0.00.0-0.0-0.10.00.00.60.1
Time >=10cm from walls, locomotor time 10.20.20.6-0.1-0.4-0.4-0.40.50.6-0.6-0.40.00.60.8
Bouts of movement, locomotor time 10.20.21.80.30.20.20.2-0.1-0.2-0.10.20.41.4-0.2
Total resting periods, locomotor time 10.20.21.40.10.10.10.1-0.1-0.3-0.10.20.41.2-0.3
Rest time, locomotor task time 10.40.51.0-1.0-0.8-0.8-0.80.80.4-0.9-0.6-0.20.4-0.0
Distance moved, locomotor task time 10.81.21.91.41.31.31.3-1.3-1.11.21.00.70.2-0.6
Vertical activity count, locomotor time 10.30.61.61.30.90.90.9-0.8-0.50.70.70.7-0.3-0.2
Time >=10cm from walls, locomotor time 20.91.42.11.51.31.31.2-1.2-1.21.01.01.01.2-0.9
Bouts of movement, locomotor time 20.10.10.4-0.10.10.10.1-0.4-0.40.60.2-0.4-0.1-0.4
Total resting periods, locomotor time 20.00.10.4-0.4-0.1-0.1-0.1-0.2-0.20.4-0.0-0.6-0.2-0.2
Rest time, locomotor task time 20.00.00.2-0.4-0.1-0.1-0.10.1-0.0-0.1-0.0-0.10.1-0.1
Distance moved, locomotor task time 20.60.71.51.21.01.00.9-0.8-0.70.70.70.90.6-0.4
Vertical activity count, locomotor time 20.00.00.20.40.10.10.1-0.10.10.1-0.00.0-0.50.2
Light reinforcement 10.30.71.91.41.01.01.0-0.8-0.71.00.40.7-0.6-0.3
Light reinforcement 20.30.41.40.4-0.4-0.4-0.40.60.70.2-1.2-0.6-0.70.8
Bone: marrow area0.10.30.90.20.40.40.4-0.6-0.50.40.70.3-0.9-0.2
Bone: maximum diameter0.30.61.1-1.0-0.9-0.9-0.90.60.8-0.4-0.6-1.00.10.8
Bone: maximum force0.61.11.61.01.21.21.2-1.3-1.21.21.10.60.6-0.7
Bone: maximum moment0.71.21.91.01.21.21.2-1.4-1.21.31.10.60.7-0.8
Mean time between licks in bursts0.61.42.6-1.6-1.3-1.3-1.31.01.2-0.7-0.9-1.50.31.3
Mean num. licks in bursts0.30.51.01.00.80.80.8-0.7-0.70.70.50.70.6-0.4
Cd content in liver0.10.10.4-0.5-0.3-0.3-0.30.20.3-0.0-0.2-0.5-0.60.3
Co content in liver0.81.01.5-1.2-1.2-1.1-1.11.11.0-1.2-0.6-0.7-0.11.0
Cu content in liver3.33.95.02.22.22.22.2-2.2-2.12.01.81.60.6-1.8
Fe content in liver1.11.42.61.01.21.21.2-1.1-1.30.21.61.60.9-0.9
K content in liver0.30.30.90.60.40.40.4-0.4-0.31.0-0.2-0.3-0.7-0.4
Mg content in liver1.31.43.8-0.7-0.9-0.9-1.00.61.00.6-1.5-1.9-1.80.8
Mn content in liver0.30.41.50.40.10.10.1-0.2-0.11.2-0.6-0.8-1.2-0.0
Na content in liver0.60.71.80.70.70.70.7-0.5-0.8-0.31.11.30.9-0.6
Rb content in liver1.21.43.50.50.90.90.9-0.8-1.2-0.61.91.81.8-0.4
Se content in liver0.10.10.30.50.10.10.10.10.10.3-0.5-0.10.1-0.4
Sr content in liver1.00.92.90.2-0.1-0.1-0.2-0.10.41.7-1.4-1.7-1.40.0
Zn content in liver1.71.93.51.41.61.61.5-1.7-1.51.91.20.60.4-1.2
Bone: minimum diameter0.30.61.2-1.0-0.9-0.9-0.90.60.8-0.3-0.7-1.10.30.8
Time in familiar zone, hab. session 11.00.92.4-1.3-1.1-1.1-1.01.00.9-1.6-0.2-0.20.40.8
Time in novel zone, hab. session 10.40.41.11.00.70.70.7-0.5-0.60.70.10.50.3-0.5
Total zone transitions, hab. session 10.71.03.11.10.90.90.9-1.0-0.71.80.1-0.2-1.5-0.6
Total locomotion distance, hab. session 10.20.30.70.80.60.60.5-0.4-0.40.8-0.00.2-0.4-0.4
Locomotion velocity, hab. session 10.20.30.80.80.60.60.6-0.5-0.40.90.00.2-0.6-0.5
Time in familiar zone, hab. session 20.40.41.1-1.1-0.7-0.7-0.70.40.5-0.4-0.2-0.80.70.5
Time in novel zone, hab. session 20.10.10.80.20.20.20.2-0.1-0.2-0.10.20.4-0.90.1
Total zone transitions, hab. session 20.50.73.70.50.30.30.2-0.5-0.11.5-0.5-0.9-1.9-0.1
Total locomotion distance, hab. session 20.30.41.00.80.60.60.5-0.5-0.41.0-0.1-0.0-0.9-0.5
Locomotion velocity, hab. session 20.20.30.90.80.40.40.4-0.3-0.20.9-0.3-0.1-0.9-0.5
Novel to familiar place preference ratio0.70.81.00.81.01.01.0-1.0-1.00.90.90.7-0.7-0.5
Novelty place preference0.70.71.00.81.01.01.0-1.0-1.00.80.90.7-0.7-0.5
Time in novel zone, NPP test0.90.91.31.01.11.11.1-1.1-1.10.81.10.9-0.4-0.6
Total zone transitions, NPP test2.23.210.71.91.81.81.8-2.0-1.63.30.6-0.2-1.3-1.5
Total locomotion distance, NPP test0.81.02.71.31.11.11.1-1.1-0.91.60.30.3-0.4-1.0
Locomotion velocity, NPP test0.81.23.21.41.21.21.2-1.1-0.91.80.30.2-0.6-1.0
Intraocular pressure0.91.43.21.11.21.21.2-1.0-1.3-0.01.71.80.1-0.8
Delta distance traveled before/after self-admin0.10.10.30.40.20.20.1-0.10.10.20.00.10.50.4
Delta ambulatory time before/after self-admin0.70.92.01.41.11.11.0-1.0-0.70.90.80.80.8-0.2
Parametrial fat weight0.51.23.31.81.31.31.2-1.1-0.81.40.50.80.5-0.4
Pavlov. Cond. lever latency3.54.45.72.22.42.42.4-2.2-2.41.42.42.30.9-1.7
Pavlov. Cond. magazine entry latency5.97.69.9-3.2-3.1-3.1-3.12.83.0-2.1-2.7-2.9-1.22.3
Pavlov. Cond. change in total contacts1.21.32.4-1.5-1.3-1.3-1.31.11.1-1.2-0.7-0.90.21.0
Pavlov. Cond. index score5.06.38.2-2.9-2.9-2.9-2.92.62.8-1.9-2.5-2.7-1.12.1
Pavlov. Cond. latency score4.96.28.0-2.8-2.8-2.8-2.82.52.8-1.8-2.5-2.7-1.12.1
Pavlov. Cond. lever contacts2.22.63.7-1.7-1.8-1.8-1.81.61.8-0.9-1.9-1.9-0.61.2
Pavlov. Cond. magazine entry number6.07.510.33.23.13.13.1-2.8-3.02.32.52.81.2-2.4
Pavlov. Cond. intertrial magazine entries0.40.50.70.70.80.80.8-0.7-0.80.40.80.80.2-0.7
Pavlov. Cond. lever-magazine prob. diff.4.55.57.2-2.7-2.7-2.7-2.72.42.6-1.8-2.3-2.5-1.02.0
Pavlov. Cond. response bias5.46.78.8-3.0-2.9-2.9-2.92.62.8-1.9-2.6-2.8-1.22.1
Pavlov. Cond. lever latency0.71.02.8-1.0-1.1-1.0-1.01.21.0-1.7-0.6-0.10.60.6
Pavlov. Cond. magazine entry latency0.40.53.4-0.4-0.3-0.3-0.30.00.40.7-0.6-1.1-1.80.3
Pavlov. Cond. change in total contacts2.03.25.51.92.02.02.0-2.2-1.92.31.60.91.0-1.1
Pavlov. Cond. index score0.30.52.00.60.60.60.6-0.8-0.51.40.1-0.4-0.8-0.3
Pavlov. Cond. latency score0.30.41.70.40.40.40.4-0.6-0.41.3-0.0-0.5-0.8-0.2
Pavlov. Cond. lever contacts0.91.22.81.21.21.21.2-1.3-1.11.70.80.4-0.5-0.7
Pavlov. Cond. magazine entry number0.40.52.90.60.40.40.4-0.0-0.3-0.60.51.21.7-0.5
Pavlov. Cond. intertrial magazine entries0.50.72.3-1.1-0.9-0.9-0.90.90.7-1.5-0.1-0.00.60.6
Pavlov. Cond. lever-magazine prob. diff.0.30.42.00.50.50.50.5-0.7-0.41.40.0-0.5-0.9-0.2
Pavlov. Cond. response bias0.30.41.70.40.50.40.4-0.7-0.41.30.1-0.5-1.2-0.1
Time in closed arm before self-admin0.91.22.30.21.11.11.2-1.3-1.51.11.40.6-0.1-1.2
Time in closed arm after self-admin0.20.21.0-1.0-0.4-0.4-0.40.20.0-0.1-0.1-0.5-0.3-0.0
Time in open arm before self-admin0.91.01.7-0.7-1.1-1.1-1.21.21.3-1.0-1.2-0.90.20.6
Time in open arm after self-admin0.20.31.2-0.3-0.4-0.4-0.40.40.6-0.4-0.4-0.3-1.10.4
Bone: periosteal estimation0.00.10.2-0.10.20.20.2-0.4-0.30.30.4-0.10.00.0
Bone: periosteal perimeter0.81.32.1-1.5-1.3-1.3-1.31.01.2-0.9-0.9-1.2-0.61.1
Bone: post-yield work0.10.21.90.10.10.10.1-0.2-0.10.40.0-0.2-1.40.0
Progressive ratio test 1 active lever presses0.20.21.4-0.50.00.00.1-0.3-0.40.30.3-0.4-1.2-0.3
Progressive ratio test 1 breakpoint0.20.21.5-0.5-0.0-0.00.0-0.2-0.30.30.2-0.4-1.2-0.3
Progressive ratio test 1 inactive lever presses0.20.31.2-1.1-0.6-0.7-0.60.40.3-0.3-0.3-0.80.20.1
Progressive ratio test 2 active lever presses1.72.04.0-2.0-1.6-1.6-1.61.31.3-0.9-1.2-1.7-1.10.9
Progressive ratio test 2 breakpoint1.82.13.9-2.0-1.6-1.6-1.61.31.4-0.9-1.2-1.7-1.00.9
Progressive ratio test 2 inactive lever presses1.62.76.8-2.6-1.9-1.9-1.91.41.4-1.0-1.3-2.10.10.9
Incentive Sensitization - Responses1.72.33.2-1.7-1.8-1.8-1.81.61.7-1.2-1.5-1.6-0.11.2
Incentive Sensitization - Breakpoint1.82.43.2-1.7-1.8-1.8-1.81.61.7-1.2-1.5-1.6-0.11.2
Sum of active levers in priming session hrs 5-60.10.00.20.0-0.0-0.0-0.00.1-0.1-0.2-0.00.1-0.5-0.5
Progressive ratio1.92.94.21.41.91.91.9-2.0-2.11.71.91.40.9-1.3
Food seeking constrained by brief footshock0.91.12.0-1.4-1.2-1.2-1.21.01.1-0.7-1.0-1.2-0.10.9
Seeking ratio, punishment vs. effort3.55.16.8-2.3-2.6-2.6-2.62.42.6-1.9-2.4-2.2-0.61.9
Retroperitoneal fat weight1.25.08.62.92.62.62.6-2.3-2.12.21.82.01.3-1.6
Reaction time number correct0.20.41.0-1.0-0.7-0.7-0.70.50.5-0.5-0.2-0.6-0.00.6
Reaction time mean minus median0.10.10.60.70.30.30.2-0.1-0.10.5-0.3-0.00.6-0.2
Reaction time mean minus median AUC0.10.30.70.80.60.60.5-0.5-0.50.60.20.40.6-0.3
Reaction time num false alarms0.20.30.7-0.8-0.5-0.5-0.50.30.3-0.70.1-0.2-0.70.4
Reaction time num false alarms AUC0.10.10.4-0.5-0.2-0.2-0.20.20.1-0.60.30.1-0.50.3
Reaction time trials correct on left0.20.41.0-1.0-0.7-0.7-0.70.50.5-0.5-0.2-0.6-0.00.6
Reaction time trials on left0.20.41.0-1.0-0.7-0.7-0.70.50.5-0.6-0.2-0.6-0.10.6
Reaction time mean0.00.00.10.20.10.10.1-0.1-0.10.00.20.2-0.3-0.3
Reaction time mean AUC0.00.00.00.10.10.10.1-0.0-0.1-0.10.10.1-0.2-0.2
Median of all reaction times0.00.10.4-0.1-0.0-0.00.0-0.0-0.0-0.20.20.2-0.6-0.2
Reaction time omissions0.20.31.7-0.2-0.4-0.4-0.40.60.3-1.30.10.50.30.3
Reaction time false alarm rate0.00.10.2-0.2-0.1-0.1-0.10.10.1-0.40.20.3-0.40.1
Reaction time premature initiation rate1.82.56.52.51.71.71.6-1.3-1.31.01.01.72.0-0.8
Reaction time premature initiations0.81.43.71.91.21.21.1-0.9-0.90.70.71.11.9-0.3
Std. dev. reaction times0.10.20.30.60.40.40.4-0.4-0.40.40.30.30.0-0.4
Reaction time trials completed0.20.41.0-1.0-0.7-0.7-0.70.50.5-0.6-0.2-0.6-0.10.6
Reaction time trials AUC0.30.51.4-1.2-0.8-0.8-0.80.60.6-0.6-0.3-0.7-0.10.7
Run reversals in cocaine runway, females1.11.11.7-0.8-1.1-1.1-1.11.31.3-1.3-1.2-0.5-0.41.0
Run reversals in cocaine runway, males1.01.03.81.60.90.90.8-0.7-0.40.50.50.92.00.0
Latency to leave start box in cocaine runway0.30.31.50.70.50.50.4-0.4-0.10.40.30.41.20.3
Latency to leave start box in cocaine runway, F0.60.71.11.10.90.90.9-1.0-0.80.90.80.60.8-0.1
Latency to leave start box in cocaine runway, M0.80.71.4-0.7-1.0-1.0-1.01.11.2-0.9-1.0-0.50.40.5
Std. dev. time between licks in bursts2.83.86.2-2.5-2.2-2.2-2.21.72.0-1.2-1.6-2.3-1.71.9
Total sessions with >9 infusions0.40.50.7-0.8-0.8-0.8-0.80.70.8-0.5-0.7-0.9-0.60.6
Short access day 1 total inactive lever presses2.43.26.0-2.5-2.0-2.0-2.01.61.7-1.1-1.5-2.1-1.51.2
Short access day 10 total inactive lever presses0.10.32.90.50.30.30.2-0.2-0.20.10.10.31.7-0.2
Short access day 1 total infusions2.23.03.9-1.8-2.0-2.0-2.01.91.9-1.5-1.7-1.7-0.51.4
Short access day 10 total infusions1.72.23.5-1.9-1.6-1.6-1.61.31.5-1.0-1.3-1.7-1.41.1
Short access total infusions2.53.24.5-2.1-2.0-2.0-2.01.71.8-1.3-1.6-1.9-1.71.4
Short access day 1 locomotion0.50.60.8-0.7-0.9-0.9-0.90.80.9-0.6-0.8-0.8-0.50.7
Short access day 10 total locomotion0.10.21.40.00.20.20.2-0.3-0.30.30.30.0-1.2-0.2
Short access total locomotion0.30.32.9-0.3-0.2-0.2-0.30.10.2-0.0-0.2-0.4-1.70.2
One hour access (0.3 mA shock)0.60.72.1-1.5-0.7-0.7-0.70.30.4-0.1-0.2-1.1-1.50.2
Compulsive drug intake0.50.61.0-0.6-0.9-0.9-0.91.01.0-0.9-0.9-0.40.10.8
One hour access (shock baseline)0.40.72.9-1.4-0.6-0.6-0.60.20.30.0-0.1-1.1-1.70.1
Social response proportion0.30.31.00.80.40.40.4-0.2-0.4-0.20.30.81.0-0.2
Social responses0.20.30.70.90.60.60.6-0.5-0.50.60.30.40.2-0.1
Social time0.60.81.5-0.1-0.8-0.8-0.91.11.1-0.8-1.2-0.40.90.9
Soleus weight3.39.913.43.43.63.63.6-3.6-3.53.72.92.20.3-2.5
Bone: stiffness0.20.30.80.40.50.50.5-0.6-0.50.50.50.40.9-0.3
Tibialis anterior weight0.00.10.8-0.00.20.20.2-0.4-0.20.60.2-0.3-0.9-0.1
Time to tail flick, vehicle, before self-admin1.71.82.51.11.41.41.4-1.3-1.61.01.31.31.4-1.4
Time to tail flick, vehicle, after self-admin0.10.10.30.60.40.40.4-0.3-0.20.40.20.30.60.1
Time to tail flick, test, before self-admin0.20.20.40.6-0.2-0.2-0.20.40.5-0.4-0.70.10.20.4
Time to tail flick, test, after self-admin0.10.10.5-0.7-0.4-0.4-0.40.30.3-0.2-0.2-0.50.3-0.1
Delta time to tail flick, vehicle, before/after SA0.50.51.1-0.5-0.7-0.7-0.70.60.9-0.4-0.8-0.80.11.0
Delta time to tail flick, test, before/after SA0.30.31.7-1.3-0.3-0.3-0.2-0.0-0.10.10.2-0.5-0.8-0.3
Tibia length5.415.027.14.24.44.44.3-4.6-4.25.23.11.91.2-3.3
Ambulatory time before self-admin0.40.61.2-1.1-0.9-0.9-0.90.80.6-0.7-0.7-0.7-0.80.5
Ambulatory time after self-admin0.00.00.30.1-0.1-0.1-0.10.20.2-0.1-0.20.00.10.5
Bone: tissue strength2.92.93.61.71.91.91.9-1.9-1.91.71.71.41.3-1.4
Total heroin consumption1.61.92.61.61.61.61.6-1.5-1.41.31.41.20.1-1.3
Bone: trabecular number0.50.91.5-1.0-1.0-1.0-1.00.90.9-0.9-0.8-0.7-1.20.7
Bone: trabecular spacing1.52.04.71.51.41.41.4-1.3-1.31.01.11.32.2-1.1
Bone: trabecular thickness0.10.10.60.30.20.20.1-0.1-0.10.5-0.2-0.2-0.8-0.1
Bone: trabecular tissue density0.30.40.90.90.70.70.7-0.7-0.60.90.20.30.5-0.6
Water consumed over 24 hours0.10.10.60.20.10.10.1-0.2-0.10.4-0.0-0.10.7-0.1
Number of responses in last shaping day0.20.20.6-0.8-0.5-0.5-0.50.40.3-0.2-0.3-0.50.40.1