Alpl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	Alpl	0.07	0.05	3.5e-09	0.1	0.09	0.09	0.09	3.7e-09	9.7e-09	1.4e-08	4.8e-09
2	NAcc	gene expression	Alpl	0.03	0.02	1.6e-05	0.03	0.03	0.03	0.03	6.9e-05	2.1e-05	9.7e-05	4.0e-05
3	Adipose	gene expression	Alpl	0.09	0.05	7.4e-14	0.12	0.12	0.12	0.12	1.0e-13	1.1e-13	4.8e-13	2.6e-13
4	Liver	gene expression	Alpl	0.16	0.09	0.0e+00	0.23	0.25	0.24	0.25	5.0e-25	3.5e-27	1.0e-26	4.3e-27
5	pVTA	gene expression	Alpl	0.03	0.03	3.0e-03	0.03	0.03	0.01	0.03	1.5e-03	3.3e-03	3.2e-02	3.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1	0.3
Area under the delay curve	0.4	0.4	0.6	-0.5	0.7	-0.7	-0.8	-0.6
BMI with tail	0.1	0.4	0.8	0.9	-0.7	0.5	0.2	0.4
BMI without tail	1.5	4.5	5.6	2.4	-2.2	2.1	1.9	2.0
Body weight	1.8	7.9	11.7	3.4	-2.6	2.5	2.7	2.7
Weight adjusted by age	1.4	2.2	2.9	1.4	-1.5	1.7	1.4	1.3
Bone surface	0.1	0.1	0.5	0.3	0.2	-0.2	-0.0	0.7
Bone volume	0.0	0.1	0.1	0.2	0.3	-0.3	-0.0	0.3
Breakpoint value in progressive ratio session	1.6	1.9	2.2	1.4	-1.5	1.5	1.2	1.4
Number of licking bursts	0.0	0.0	0.0	0.2	-0.2	0.1	0.1	-0.1
Context. condit. distance diff. score	0.6	0.7	1.0	0.9	-1.0	1.0	0.8	0.4
Locomotion velocity, session 1	1.3	1.4	2.2	-0.6	1.4	-1.5	-1.4	-0.6
Locomotion distance, session 1	2.2	2.7	3.5	-1.5	1.8	-1.9	-1.8	-1.2
Locomotion velocity, session 2	3.7	4.3	5.6	-1.8	2.4	-2.4	-2.1	-1.8
Locomotion distance, session 2	0.9	1.2	2.0	-0.9	1.4	-1.4	-1.1	-0.4
Locomotion velocity, session 3	1.6	1.8	2.5	-1.4	1.1	-1.2	-1.4	-1.6
Locomotion distance, session 3	0.6	0.6	0.9	0.8	-0.9	0.9	0.7	0.5
Stereotopy head waving bouts, day 3	1.2	1.5	2.0	-1.2	1.4	-1.4	-1.1	-0.8
Stereotopy head waving duration, day 3	0.5	0.6	0.9	-0.5	1.0	-1.0	-0.7	-0.5
Locomotion velocity, session 7	2.3	2.5	2.9	1.5	-1.7	1.7	1.5	1.5
Locomotion distance, session 7	0.5	0.6	0.7	0.8	-0.8	0.8	0.7	0.8
Stereotopy head waving bouts, day 7	0.2	0.3	0.6	0.6	-0.3	0.3	0.3	0.8
Stereotopy head waving duration, day 7	0.2	0.3	0.5	0.7	-0.2	0.2	0.3	0.7
Locomotion velocity, session 8	0.6	0.8	1.3	-0.2	1.1	-1.1	-1.2	-0.3
Locomotion distance, session 8	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.2	0.2
Degree of sensitization distance	0.2	0.2	0.4	-0.5	0.6	-0.5	-0.5	-0.2
Degree of sensitization stereotypy	1.4	1.6	2.1	1.3	-1.2	1.1	1.1	1.4
Conditioned locomotion	1.1	1.3	1.7	-1.3	1.1	-1.1	-1.3	-0.7
Cocaine response after cond. corrected	0.2	0.2	0.7	0.0	0.2	-0.1	-0.3	-0.9
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.3	-0.2	0.2	0.1	-0.5
Cocaine response before conditioning	1.1	1.3	1.9	0.8	-1.2	1.1	1.4	1.2
Saline control response	0.1	0.2	0.5	-0.4	0.4	-0.5	-0.7	0.0
Bone: connectivity density	0.3	0.5	1.3	0.8	-0.4	0.4	0.5	1.2
Bone: cortical apparent density	1.6	2.1	3.0	1.2	-1.7	1.7	1.5	1.0
Bone: cortical area	0.7	1.1	1.5	1.1	-0.9	0.9	1.1	1.2
Bone: cortical porosity	0.9	1.0	1.4	-1.1	1.2	-1.1	-0.9	-0.5
Bone: cortical porosity	1.0	1.1	1.8	-1.0	1.3	-1.3	-1.0	-0.4
Bone: cortical thickness	0.4	0.7	0.8	0.7	-0.9	0.9	0.8	0.8
Bone: cortical thickness	0.2	0.3	0.8	-0.4	0.3	-0.3	-0.4	-0.9
Bone: cortical tissue density	1.3	1.8	2.7	1.1	-1.6	1.6	1.4	0.9
Condit. Reinf. active minus inactive responses	0.6	0.6	1.1	-1.1	0.7	-0.6	-0.4	-1.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.5	-0.7	0.4	-0.3	-0.1	-0.4
Condit. Reinf. active responses	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.0	-0.7
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.3	0.4	-0.5	0.2	-0.1
Incentive salience index mean	0.7	0.8	1.7	-1.3	0.6	-0.6	-0.1	-1.3
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.8	0.1	-0.0	0.6	-0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.3	0.3	-0.4	-0.4	-0.6
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.1	-0.7	0.9	-0.9	-1.0	-0.9
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	-0.2	0.1	0.2	0.0
Condit. Reinf. inactive responses	0.9	1.1	1.8	0.9	-1.0	1.0	1.4	1.0
Condit. Reinf. lever presses	0.6	0.8	1.1	-1.0	0.9	-0.9	-0.5	-1.0
Condit. Reinf. lever reinforcers received	0.0	0.0	0.1	0.1	-0.2	0.1	0.3	0.0
Conditioned reinforcement - actives	0.8	1.4	1.9	1.4	-1.1	1.1	1.3	1.1
Conditioned reinforcement - inactives	1.0	1.5	2.8	1.7	-1.0	1.0	1.1	1.3
Conditioned locomotion	2.3	2.9	3.4	1.8	-1.8	1.8	1.8	1.4
Patch foraging indifference point 0 sec	0.1	0.2	0.6	0.6	-0.3	0.3	0.2	0.8
Patch foraging indifference point AUC	1.0	1.4	2.2	0.9	-1.4	1.5	1.3	0.7
Delay disc. indifference point, 0s delay	1.0	1.1	1.6	-0.9	1.1	-1.2	-1.2	-0.8
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.2	0.1	-0.0	-0.1	-0.3
Delay disc. indifference point, 2s delay	0.2	0.2	0.3	-0.4	0.5	-0.5	-0.6	-0.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.5	-0.5	0.3	-0.3	-0.1	-0.7
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	-0.3	0.7	-0.7	-0.7	-0.1
Delay disc. indifference point, 8s delay	0.5	0.6	0.7	-0.7	0.7	-0.7	-0.8	-0.9
Indifference point function ln k	3.5	6.1	7.9	-2.3	2.8	-2.7	-2.4	-2.2
Indifference point function log k	3.5	6.1	7.9	-2.3	2.8	-2.7	-2.4	-2.2
Patch foraging total patch changes 0 sec	0.0	0.1	0.3	0.4	-0.1	0.1	0.0	0.5
Patch foraging total patch changes 12 sec	1.8	2.4	2.8	1.7	-1.4	1.5	1.4	1.6
Patch foraging total patch changes 18 sec	0.8	1.3	1.4	1.1	-1.1	1.2	1.1	1.2
Patch foraging total patch changes 24 sec	0.8	1.4	1.9	1.4	-1.2	1.3	0.9	1.1
Patch foraging total patch changes 6 sec	2.7	4.2	4.8	2.0	-2.1	2.2	1.8	2.1
Patch foraging time to switch 0 sec	1.1	2.2	2.8	1.7	-1.4	1.4	1.4	1.6
Patch foraging water rate 0 sec	1.3	2.8	3.7	-1.5	1.8	-1.8	-1.9	-1.4
Patch foraging water rate 12 sec	1.5	3.1	3.8	-1.7	1.8	-1.7	-1.9	-1.7
Patch foraging water rate 18 sec	1.0	1.5	2.3	-1.1	1.5	-1.5	-1.0	-0.9
Patch foraging water rate 24 sec	2.2	3.1	4.7	-1.3	2.1	-2.2	-1.8	-1.2
Patch foraging water rate 6 sec	3.0	4.4	5.0	-2.0	2.2	-2.2	-2.2	-1.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.5	-0.4	0.4	-0.4	-0.7	-0.2
Distance traveled before self-admin	4.4	5.8	6.9	2.3	-2.6	2.6	2.3	2.1
Distance traveled after self-admin	5.0	6.1	6.9	2.6	-2.5	2.5	2.2	2.6
Extensor digitorum longus weight	0.1	0.5	0.8	-0.6	0.8	-0.8	-0.9	-0.1
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.1	0.3
Bone: elastic work	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1	0.4
Bone: endosteal estimation	0.4	1.0	2.6	1.3	-0.3	0.3	0.8	1.6
Bone: endosteal perimeter	0.2	0.4	0.8	-0.3	0.9	-0.9	-0.5	-0.1
Epididymis fat weight	0.0	0.1	0.2	0.5	0.2	-0.2	-0.2	-0.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.5	0.7	-0.7	-0.2	-0.3
Delta time in open arm before/after self-admin	0.3	0.3	0.7	0.9	-0.3	0.3	0.3	0.5
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	0.3	-0.2	0.2	0.3	0.3
Delay discount exponential model param	0.3	0.3	0.4	0.4	-0.6	0.6	0.7	0.5
Extinction: sum of active levers before priming	0.3	0.3	1.0	0.6	-0.3	0.3	0.3	1.0
Active lever presses in extinction session 6	0.1	0.1	0.3	0.4	-0.3	0.3	0.2	0.5
Bone: final force	1.2	1.8	2.2	1.3	-1.3	1.4	1.3	1.5
Bone: final moment	0.7	1.2	1.5	1.0	-1.0	1.0	1.1	1.2
Food consumed during 24 hour testing period	1.0	1.4	1.5	1.2	-1.2	1.2	1.1	1.2
Glucose	2.6	4.1	5.2	2.1	-2.3	2.2	1.9	1.6
Heart weight	0.8	1.3	1.8	1.1	-1.3	1.2	1.1	0.9
Delay discount hyperbolic model param	0.4	0.5	0.6	0.5	-0.7	0.7	0.8	0.6
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.1	0.3	-0.2	0.1	-0.3
Intermittent access intake escalation	0.0	0.0	0.1	0.0	0.3	-0.2	0.0	-0.3
Intermittent access intake escalation 2	0.4	0.5	0.7	-0.6	0.8	-0.8	-0.4	-0.8
Intermitt. access day 1 inactive lever presses	1.2	4.7	5.4	2.1	-2.1	2.2	2.3	2.0
Intermitt. access day 15 inactive lever presses	0.6	1.3	1.5	1.0	-1.2	1.2	1.1	1.1
Intermitt. access escalation Index	0.2	0.3	0.5	0.5	-0.7	0.6	0.2	0.6
Intermittent access day 1 total infusions	6.4	10.4	11.0	3.2	-3.3	3.3	3.2	3.2
Intermittent access day 15 total infusions	3.1	4.6	5.1	2.3	-2.1	2.2	2.2	1.9
Intermittent access terminal intake (last 3 days)	2.6	3.4	4.2	1.9	-1.8	1.8	2.0	1.5
Intermittent access total infusions	5.2	6.2	6.8	2.5	-2.6	2.6	2.6	2.2
Intermittent access day 1 locomotion	1.9	2.4	2.8	1.6	-1.6	1.5	1.4	1.7
Intermittent access day 15 total locomotion	0.7	1.3	1.9	1.4	-1.0	1.0	1.2	1.2
Intermittent access total locomotion	3.2	3.8	4.4	2.1	-1.9	1.9	2.0	1.8
Intermittent access standard deviation	0.9	1.8	2.4	1.3	-1.3	1.3	1.5	1.3
Left kidney weight	7.1	33.2	38.7	6.2	-5.6	5.6	5.8	5.6
Right kidney weight	3.3	14.9	17.6	4.2	-3.7	3.7	4.2	3.5
Cocaine induced anxiety	0.1	0.2	0.3	0.6	-0.3	0.3	0.5	0.5
Post-drug Anxiety	0.3	0.3	0.4	-0.5	0.5	-0.6	-0.5	-0.7
Baseline Anxiety	1.3	1.5	2.1	-1.4	1.0	-1.1	-1.2	-1.3
Tail length	3.2	12.7	14.5	3.6	-3.3	3.4	3.8	3.7
Length with tail	2.9	12.7	15.3	3.9	-3.2	3.2	3.7	3.8
Length without tail	0.7	2.3	3.2	1.8	-1.4	1.3	1.5	1.6
Times rat made contact with spout	0.3	0.4	0.5	0.5	-0.7	0.7	0.6	0.4
Lifetime Intake	4.5	5.4	6.0	2.3	-2.4	2.4	2.4	2.1
Liver weight, left	1.7	2.8	4.8	1.9	-1.1	1.2	1.7	2.2
Liver weight, right	2.3	4.1	4.9	2.2	-1.7	1.7	2.2	2.2
Locomotor activity	1.0	1.5	1.8	1.3	-1.3	1.1	1.2	1.3
Locomotor testing distance	0.6	1.0	1.7	1.3	-0.8	0.6	0.8	1.3
Locomotor testing rearing	0.7	1.4	2.5	1.6	-0.9	0.7	0.9	1.5
Locomotion in novel chamber	0.4	0.4	1.0	1.0	-0.7	0.4	-0.2	0.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	0.3	0.2	-0.2	-0.1	0.1
Fecal boli incidents, locomotor time 1	4.8	7.0	8.5	2.6	-2.6	2.6	2.5	2.9
Change in fecal boli incidents, locomotor task	5.4	5.3	6.3	-2.4	2.2	-2.2	-2.2	-2.5
Time >=10cm from walls, locomotor time 1	2.7	2.8	3.5	1.4	-1.9	1.8	1.7	1.6
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.0	0.1	-0.2	-0.5	-0.3
Total resting periods, locomotor time 1	0.0	0.0	0.1	0.1	-0.0	-0.0	-0.3	-0.2
Rest time, locomotor task time 1	0.3	0.4	0.8	0.9	-0.5	0.4	0.2	0.8
Distance moved, locomotor task time 1	0.6	0.9	1.3	-1.1	0.8	-0.9	-0.8	-1.1
Vertical activity count, locomotor time 1	0.6	1.4	1.9	-1.4	1.1	-1.0	-1.0	-1.4
Time >=10cm from walls, locomotor time 2	1.2	1.8	2.6	1.1	-1.5	1.6	1.1	1.2
Bouts of movement, locomotor time 2	0.1	0.2	0.5	-0.7	0.0	0.0	-0.3	-0.6
Total resting periods, locomotor time 2	0.2	0.3	0.6	-0.8	0.2	-0.2	-0.5	-0.8
Rest time, locomotor task time 2	0.7	0.9	1.2	1.1	-1.0	0.9	0.7	0.9
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.2	0.1	-0.2	0.0	0.4
Vertical activity count, locomotor time 2	0.3	0.4	0.5	-0.7	0.7	-0.6	-0.5	-0.6
Light reinforcement 1	0.2	0.6	0.8	0.4	-0.9	0.9	0.7	0.8
Light reinforcement 2	0.0	0.0	0.2	-0.4	-0.0	0.1	-0.2	-0.2
Bone: marrow area	0.4	0.9	2.4	1.2	-0.3	0.3	0.7	1.6
Bone: maximum diameter	0.4	0.7	1.3	1.1	-0.5	0.5	0.8	1.1
Bone: maximum force	0.6	1.0	1.2	1.0	-0.9	0.9	1.1	1.1
Bone: maximum moment	0.3	0.5	0.7	0.7	-0.6	0.6	0.8	0.9
Mean time between licks in bursts	0.3	0.7	0.8	-0.7	0.9	-0.9	-0.8	-0.8
Mean num. licks in bursts	0.2	0.3	0.5	0.4	-0.6	0.6	0.6	0.7
Cd content in liver	5.3	5.9	7.1	1.8	-2.7	2.7	2.4	2.5
Co content in liver	0.5	0.6	1.8	0.8	-0.2	0.3	0.6	1.4
Cu content in liver	0.4	0.4	0.8	0.6	-0.6	0.6	0.6	0.9
Fe content in liver	0.1	0.1	0.2	-0.5	0.1	-0.2	-0.0	-0.5
K content in liver	0.0	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.2
Mg content in liver	0.6	0.6	1.2	0.9	-0.7	0.7	0.6	1.1
Mn content in liver	0.8	0.9	1.1	1.0	-1.0	1.0	1.0	0.7
Na content in liver	0.0	0.0	0.1	-0.0	-0.1	0.0	0.3	-0.2
Rb content in liver	4.2	4.9	6.7	2.3	-2.1	2.1	2.0	2.6
Se content in liver	0.1	0.1	0.2	0.5	-0.1	0.0	-0.0	0.2
Sr content in liver	2.8	2.4	2.9	-1.2	1.7	-1.7	-1.6	-1.6
Zn content in liver	2.8	3.2	3.6	1.8	-1.9	1.8	1.5	1.9
Bone: minimum diameter	1.0	1.8	3.2	1.6	-0.8	0.8	1.4	1.8
Time in familiar zone, hab. session 1	1.4	1.4	1.8	1.0	-1.3	1.4	1.0	1.2
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.1	0.2	-0.3	-0.2	0.1
Total zone transitions, hab. session 1	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.3	0.4
Total locomotion distance, hab. session 1	0.2	0.4	0.6	0.3	0.7	-0.7	-0.4	0.8
Locomotion velocity, hab. session 1	0.4	0.5	1.1	-0.2	1.1	-1.0	-0.6	0.1
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.2	-0.5	0.5	0.6	0.4
Time in novel zone, hab. session 2	0.6	0.6	0.8	-0.6	0.7	-0.7	-0.9	-0.9
Total zone transitions, hab. session 2	1.3	1.6	2.1	-1.2	1.4	-1.4	-1.3	-0.8
Total locomotion distance, hab. session 2	1.9	2.5	3.1	-1.5	1.8	-1.7	-1.6	-1.3
Locomotion velocity, hab. session 2	1.4	1.9	2.5	-1.3	1.6	-1.6	-1.4	-1.0
Novel to familiar place preference ratio	1.0	1.1	1.3	1.1	-1.1	1.1	1.0	0.9
Novelty place preference	1.5	1.6	1.8	1.3	-1.3	1.3	1.3	1.1
Time in novel zone, NPP test	1.8	1.9	2.2	1.5	-1.5	1.5	1.3	1.2
Total zone transitions, NPP test	1.1	1.6	2.0	-1.2	1.4	-1.4	-1.3	-1.1
Total locomotion distance, NPP test	1.1	1.5	2.0	-1.2	1.4	-1.4	-1.1	-0.9
Locomotion velocity, NPP test	1.7	2.4	3.0	-1.6	1.7	-1.7	-1.4	-1.3
Intraocular pressure	0.0	0.0	0.1	-0.2	-0.2	0.1	0.2	0.3
Delta distance traveled before/after self-admin	0.4	0.4	0.8	0.9	-0.3	0.3	0.4	0.9
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.4	0.1	-0.1	-0.1	0.5
Parametrial fat weight	0.3	0.7	1.0	0.8	-1.0	1.0	1.0	0.3
Pavlov. Cond. lever latency	1.9	2.4	4.1	2.0	-1.5	1.4	1.0	1.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	0.0	-0.0	0.0	0.2
Pavlov. Cond. change in total contacts	1.6	1.7	2.1	-1.4	1.4	-1.4	-1.1	-1.2
Pavlov. Cond. index score	0.5	0.7	1.6	-1.3	0.7	-0.7	-0.4	-0.8
Pavlov. Cond. latency score	0.8	1.0	2.2	-1.5	0.9	-0.8	-0.6	-1.1
Pavlov. Cond. lever contacts	2.8	3.3	5.2	-2.3	1.8	-1.7	-1.3	-1.9
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.3	0.5	-0.5	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	2.1	2.6	3.1	-1.2	1.7	-1.7	-1.6	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.9	-1.4	0.8	-0.8	-0.6	-0.9
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.8	0.6	-0.6	-0.3	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.8	0.7	-0.5	0.5	0.3	0.9
Pavlov. Cond. magazine entry latency	1.1	1.4	1.8	-0.8	1.4	-1.4	-1.1	-1.1
Pavlov. Cond. change in total contacts	0.1	0.2	0.5	-0.4	0.4	-0.4	-0.1	-0.7
Pavlov. Cond. index score	0.9	1.2	1.5	-0.9	1.2	-1.2	-0.9	-1.2
Pavlov. Cond. latency score	1.2	1.6	2.0	-1.0	1.3	-1.4	-1.1	-1.4
Pavlov. Cond. lever contacts	0.0	0.1	0.2	-0.2	0.1	-0.2	0.1	-0.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	0.3	-0.6	0.6	0.5	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.1	-0.3	0.3	0.4	0.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.6	-0.9	1.2	-1.3	-0.9	-1.2
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.5	0.5	-0.5	-0.3	-0.8
Time in closed arm before self-admin	3.7	4.7	5.7	2.1	-2.4	2.4	2.1	1.9
Time in closed arm after self-admin	0.4	0.5	0.8	0.6	-0.6	0.6	0.9	0.6
Time in open arm before self-admin	1.2	1.4	1.6	-1.3	1.1	-1.1	-1.1	-1.2
Time in open arm after self-admin	0.5	0.5	0.7	-0.6	0.8	-0.8	-0.8	-0.6
Bone: periosteal estimation	0.7	1.4	2.9	1.4	-0.7	0.7	1.1	1.7
Bone: periosteal perimeter	0.2	0.4	0.9	0.9	-0.2	0.2	0.5	0.9
Bone: post-yield work	0.0	0.1	0.1	0.3	0.3	-0.2	0.1	0.3
Progressive ratio test 1 active lever presses	4.3	5.3	5.5	2.3	-2.3	2.3	2.3	2.3
Progressive ratio test 1 breakpoint	4.8	5.9	6.1	2.5	-2.4	2.4	2.4	2.4
Progressive ratio test 1 inactive lever presses	2.2	3.2	3.6	1.7	-1.8	1.8	1.9	1.8
Progressive ratio test 2 active lever presses	5.7	6.7	7.6	2.5	-2.6	2.6	2.8	2.4
Progressive ratio test 2 breakpoint	6.1	7.0	8.0	2.5	-2.7	2.7	2.8	2.5
Progressive ratio test 2 inactive lever presses	5.4	8.8	10.3	3.2	-2.9	2.9	2.9	3.0
Incentive Sensitization - Responses	3.9	5.4	6.3	2.2	-2.3	2.4	2.5	2.2
Incentive Sensitization - Breakpoint	4.1	5.3	6.1	2.2	-2.3	2.3	2.5	2.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.3	0.3	-0.3	-0.5	0.0
Progressive ratio	0.1	0.1	0.1	0.3	-0.2	0.3	0.3	0.3
Food seeking constrained by brief footshock	2.0	2.4	2.8	1.6	-1.5	1.5	1.7	1.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	-0.4	0.3	0.4	0.3
Retroperitoneal fat weight	0.4	1.6	2.0	1.3	-1.3	1.4	1.3	0.8
Reaction time number correct	0.5	1.0	1.3	-0.9	1.1	-1.1	-1.0	-0.7
Reaction time mean minus median	0.6	1.5	1.9	1.4	-1.3	1.3	0.9	1.1
Reaction time mean minus median AUC	1.4	3.4	4.3	2.1	-2.0	2.0	1.5	1.6
Reaction time num false alarms	0.1	0.1	0.3	0.4	-0.3	-0.0	0.1	0.5
Reaction time num false alarms AUC	0.0	0.0	0.1	0.2	0.0	-0.3	-0.2	0.3
Reaction time trials correct on left	0.5	1.0	1.3	-0.9	1.1	-1.1	-1.0	-0.7
Reaction time trials on left	0.5	1.0	1.4	-0.9	1.1	-1.2	-1.0	-0.7
Reaction time mean	0.2	0.3	0.5	0.5	-0.6	0.6	0.5	0.7
Reaction time mean AUC	0.0	0.1	0.2	0.2	-0.2	0.2	0.1	0.5
Median of all reaction times	0.0	0.0	0.1	-0.1	-0.1	0.1	0.2	0.3
Reaction time omissions	0.0	0.1	0.2	0.5	0.1	-0.1	-0.1	0.1
Reaction time false alarm rate	0.1	0.2	0.3	0.5	-0.4	0.2	0.3	0.5
Reaction time premature initiation rate	0.8	1.1	1.7	-0.7	1.2	-1.1	-1.3	-0.9
Reaction time premature initiations	1.2	2.1	3.0	-1.1	1.6	-1.6	-1.7	-1.1
Std. dev. reaction times	0.4	0.7	1.0	1.0	-0.8	0.8	0.4	0.9
Reaction time trials completed	0.5	1.0	1.4	-0.9	1.1	-1.2	-1.0	-0.7
Reaction time trials AUC	0.4	0.7	0.9	-0.7	0.9	-1.0	-0.9	-0.6
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.6	-0.6	0.6	0.4	0.9
Run reversals in cocaine runway, males	3.0	3.0	3.6	1.9	-1.9	1.9	1.3	1.6
Latency to leave start box in cocaine runway	0.5	0.5	0.7	-0.6	0.7	-0.8	-0.7	-0.8
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.2	0.2	-0.2	-0.4	-0.4
Latency to leave start box in cocaine runway, M	1.2	1.1	1.3	-1.0	1.1	-1.2	-0.8	-1.1
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.5	0.3	-0.3	-0.3	-0.6
Total sessions with >9 infusions	1.9	2.4	2.7	1.6	-1.4	1.4	1.6	1.5
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	0.3	-0.3	-0.1	0.2
Short access day 10 total inactive lever presses	0.2	0.4	0.5	0.7	-0.6	0.7	0.5	0.6
Short access day 1 total infusions	2.1	2.8	3.2	1.7	-1.6	1.6	1.8	1.8
Short access day 10 total infusions	3.6	4.6	4.9	2.0	-2.1	2.2	2.2	2.2
Short access total infusions	2.6	3.3	3.7	1.7	-1.7	1.7	1.9	1.9
Short access day 1 locomotion	0.4	0.5	0.6	0.7	-0.7	0.7	0.7	0.6
Short access day 10 total locomotion	2.3	4.2	5.4	2.2	-1.9	1.8	1.9	2.3
Short access total locomotion	3.1	3.7	4.1	1.9	-1.9	1.9	1.9	2.0
One hour access (0.3 mA shock)	3.6	4.2	4.4	2.1	-2.0	2.1	2.1	2.0
Compulsive drug intake	0.9	1.1	1.5	0.9	-1.0	1.1	1.2	1.0
One hour access (shock baseline)	0.8	1.3	1.5	1.2	-1.2	1.2	1.1	0.9
Social response proportion	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1
Social responses	0.1	0.1	0.2	0.4	-0.4	0.2	0.3	0.4
Social time	0.2	0.3	0.5	-0.5	0.5	-0.7	-0.5	-0.5
Soleus weight	0.2	0.6	0.9	-0.5	0.9	-1.0	-0.9	-0.5
Bone: stiffness	0.8	1.3	1.6	1.3	-1.0	0.9	1.2	1.2
Tibialis anterior weight	0.0	0.1	0.3	-0.3	0.3	-0.3	-0.5	-0.1
Time to tail flick, vehicle, before self-admin	0.5	0.5	0.8	-0.9	0.5	-0.5	-0.8	-0.7
Time to tail flick, vehicle, after self-admin	0.5	0.6	1.1	0.5	-0.9	0.9	1.0	0.5
Time to tail flick, test, before self-admin	0.2	0.2	0.4	0.6	-0.3	0.3	0.1	0.6
Time to tail flick, test, after self-admin	0.7	0.7	1.0	0.9	-0.7	0.7	1.0	1.0
Delta time to tail flick, vehicle, before/after SA	1.9	1.8	2.2	1.4	-1.3	1.3	1.5	1.2
Delta time to tail flick, test, before/after SA	0.3	0.3	0.5	-0.7	0.5	-0.5	-0.1	-0.7
Tibia length	0.6	1.7	2.5	1.6	-1.0	1.0	1.3	1.5
Ambulatory time before self-admin	2.7	4.1	4.7	1.9	-2.2	2.2	2.1	1.8
Ambulatory time after self-admin	4.2	5.0	5.9	2.4	-2.1	2.1	2.1	2.4
Bone: tissue strength	0.0	0.0	0.1	-0.2	0.0	-0.0	0.2	0.3
Total heroin consumption	0.4	0.4	0.5	0.5	-0.7	0.7	0.5	0.7
Bone: trabecular number	0.3	0.4	0.6	-0.4	0.8	-0.8	-0.7	-0.5
Bone: trabecular spacing	0.0	0.0	0.1	-0.2	-0.0	-0.0	0.0	-0.3
Bone: trabecular thickness	1.2	1.5	2.4	1.6	-1.0	1.0	1.1	1.5
Bone: trabecular tissue density	0.5	0.8	1.0	0.8	-0.9	0.9	0.9	1.0
Water consumed over 24 hours	0.0	0.0	0.0	-0.0	-0.0	0.0	0.1	0.1
Number of responses in last shaping day	0.6	0.6	0.9	0.6	-0.8	0.8	1.0	0.7