Alox5ap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Alox5ap	0.03	0.02	9.0e-05	0.03	0.04	0.02	0.03	2.4e-04	4.3e-05	1.1e-03	1.9e-04
2	BLA	gene expression	Alox5ap	0.11	0.06	5.9e-07	0.15	0.13	0.13	0.14	2.2e-08	1.8e-07	1.6e-07	7.9e-08
3	LHb	gene expression	Alox5ap	0.16	0.12	3.1e-03	0.12	0.11	0.1	0.1	7.1e-04	1.5e-03	1.8e-03	2.6e-03
4	RMTg	intron excision ratio	chr12_5757703_5757795	0.18	0.1	3.9e-04	0.06	0.05	0.01	0.03	8.5e-03	1.8e-02	1.5e-01	5.0e-02
5	RMTg	intron excision ratio	chr12_5757703_5765051	0.2	0.11	1.7e-04	0.09	0.05	0.01	0.05	2.0e-03	1.5e-02	1.3e-01	2.0e-02
6	Brain	gene expression	Alox5ap	0.11	0.06	1.4e-10	0.12	0.12	0.1	0.12	3.0e-11	4.6e-11	1.9e-09	2.8e-11
7	Liver	gene expression	Alox5ap	0.12	0.06	1.8e-12	0.08	0.07	0.06	0.07	2.7e-09	1.1e-08	1.7e-07	1.0e-08
8	Brain	intron excision ratio	chr12_5757703_5765051	0.07	0.05	6.6e-03	0.01	0.01	0	0	2.1e-02	3.9e-02	2.0e-01	1.5e-01
9	pVTA	gene expression	Alox5ap	0.32	0.1	2.8e-16	0.25	0.27	0.25	0.25	5.0e-11	4.5e-12	3.1e-11	2.6e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	2.4	4.0	11.7	-3.4	1.9	1.4	1.7	-1.7	-1.9	1.9	-2.0	-1.4
Area under the delay curve	0.4	0.4	1.1	1.1	-0.8	-0.1	-0.4	0.4	0.2	-0.6	0.8	0.4
BMI with tail	1.6	5.0	8.3	-2.9	2.6	2.3	2.2	-2.2	-2.2	1.9	-2.1	-1.7
BMI without tail	0.5	1.0	1.9	0.6	-0.5	-1.1	-0.8	0.8	0.9	-1.3	1.4	1.2
Body weight	2.3	9.7	28.9	-5.4	2.9	3.3	2.8	-2.8	-2.8	2.4	-2.6	-1.9
Weight adjusted by age	1.0	1.2	2.4	0.1	-0.9	-0.9	-1.2	1.2	1.1	-1.3	0.9	1.5
Bone surface	1.4	2.5	9.1	-3.0	1.4	1.3	1.2	-1.2	-1.4	1.4	-1.6	-0.9
Bone volume	3.3	5.6	12.6	-3.6	2.4	2.0	2.1	-2.1	-2.2	2.2	-2.4	-1.8
Breakpoint value in progressive ratio session	0.1	0.2	0.4	0.5	-0.6	-0.2	-0.3	0.3	0.3	-0.4	0.5	0.2
Number of licking bursts	0.5	0.6	2.2	-0.1	-0.5	-1.5	-0.6	0.6	0.8	-0.6	0.6	1.1
Context. condit. distance diff. score	1.2	1.4	2.4	-1.5	1.1	1.3	1.1	-1.1	-1.4	1.0	-0.9	-1.2
Locomotion velocity, session 1	0.9	1.0	1.4	0.8	-1.1	-0.7	-1.2	1.2	0.8	-1.1	0.7	1.1
Locomotion distance, session 1	2.1	2.6	3.5	1.3	-1.6	-1.4	-1.9	1.9	1.6	-1.8	1.1	1.8
Locomotion velocity, session 2	1.7	2.0	3.4	0.6	-1.2	-1.3	-1.6	1.6	1.5	-1.4	1.2	1.8
Locomotion distance, session 2	4.2	5.8	7.2	1.7	-2.5	-2.7	-2.6	2.6	2.5	-2.4	1.8	2.7
Locomotion velocity, session 3	0.7	0.9	1.5	-0.9	1.0	1.0	0.8	-0.8	-0.9	0.9	-1.2	-0.9
Locomotion distance, session 3	0.1	0.2	0.3	0.5	-0.5	-0.2	-0.5	0.5	0.3	-0.5	0.0	0.2
Stereotopy head waving bouts, day 3	1.3	1.5	2.3	0.3	-1.0	-1.1	-1.4	1.4	1.3	-1.2	1.5	1.5
Stereotopy head waving duration, day 3	0.1	0.1	0.3	0.1	-0.2	-0.4	-0.4	0.4	0.3	-0.2	0.5	0.4
Locomotion velocity, session 7	0.1	0.1	0.3	0.4	-0.2	0.2	0.2	-0.2	-0.3	0.1	-0.6	-0.3
Locomotion distance, session 7	0.1	0.1	0.5	0.7	-0.6	-0.1	0.0	-0.0	0.0	-0.1	-0.3	-0.1
Stereotopy head waving bouts, day 7	2.5	2.8	4.0	2.0	-1.7	-1.8	-1.7	1.7	1.6	-1.6	1.6	1.3
Stereotopy head waving duration, day 7	1.1	1.4	2.0	1.2	-1.1	-1.4	-1.2	1.2	1.1	-1.1	1.3	0.9
Locomotion velocity, session 8	1.3	1.6	2.0	1.0	-1.4	-1.1	-1.4	1.4	1.3	-1.4	0.9	1.3
Locomotion distance, session 8	0.4	0.5	0.9	-0.3	-0.9	-0.9	-0.7	0.7	0.6	-0.8	0.4	0.8
Degree of sensitization distance	0.2	0.2	0.4	0.6	-0.5	-0.4	-0.2	0.2	0.4	-0.3	0.4	0.4
Degree of sensitization stereotypy	0.6	0.7	1.2	1.1	-0.8	-1.1	-0.9	0.9	0.7	-0.8	0.6	0.5
Conditioned locomotion	0.5	0.6	2.0	0.6	-1.0	-1.4	-0.6	0.6	0.9	-0.4	0.1	0.6
Cocaine response after cond. corrected	0.5	0.5	0.9	-0.1	0.7	0.5	0.8	-0.8	-0.9	0.9	-0.7	-0.9
Cocaine response after cond. not corrected	0.8	0.9	1.3	-0.2	0.9	0.4	1.1	-1.1	-1.1	1.1	-1.0	-1.2
Cocaine response before conditioning	0.3	0.3	0.5	-0.4	0.4	0.1	0.7	-0.7	-0.5	0.5	-0.7	-0.6
Saline control response	4.5	5.9	7.0	1.7	-2.6	-2.3	-2.6	2.6	2.5	-2.6	2.2	2.5
Bone: connectivity density	0.6	1.0	5.8	-2.4	0.4	0.3	0.6	-0.6	-0.7	0.8	-1.0	-0.2
Bone: cortical apparent density	0.4	0.5	0.8	-0.7	0.9	0.6	0.6	-0.6	-0.7	0.9	-0.4	-0.7
Bone: cortical area	1.0	1.6	4.2	-2.0	1.2	1.4	1.1	-1.1	-1.2	1.0	-1.0	-0.9
Bone: cortical porosity	1.8	2.0	2.6	1.2	-1.3	-1.5	-1.6	1.6	1.5	-1.2	1.3	1.4
Bone: cortical porosity	2.0	2.2	2.8	1.4	-1.6	-1.4	-1.7	1.7	1.5	-1.3	1.4	1.4
Bone: cortical thickness	0.8	1.3	3.5	-1.9	1.1	1.1	1.1	-1.1	-1.1	1.0	-0.9	-0.9
Bone: cortical thickness	1.2	1.4	2.5	1.2	-1.6	-1.5	-1.1	1.1	1.0	-0.9	1.2	0.8
Bone: cortical tissue density	0.3	0.4	0.7	-0.6	0.8	0.5	0.6	-0.6	-0.7	0.9	-0.4	-0.7
Condit. Reinf. active minus inactive responses	1.0	1.1	2.0	-1.3	1.0	1.4	0.9	-0.9	-1.1	0.7	-0.7	-0.8
Condit. Reinf. active-inactive response ratio	1.8	2.0	3.0	-1.4	1.4	1.7	1.4	-1.4	-1.7	1.2	-1.1	-1.3
Condit. Reinf. active responses	0.1	0.2	0.4	-0.6	0.5	0.6	0.3	-0.3	-0.4	0.2	-0.0	-0.2
Condit. Reinf. inactive responses	0.4	0.5	0.6	0.8	-0.4	-0.7	-0.7	0.7	0.7	-0.7	0.8	0.7
Incentive salience index mean	0.3	0.4	1.0	-0.6	0.7	1.0	0.5	-0.5	-0.7	0.5	-0.3	-0.6
Condit. Reinf. lever presses	0.0	0.0	0.2	0.1	0.4	0.2	-0.1	0.1	-0.0	0.3	0.1	-0.1
Condit. Reinf. active minus inactive responses	1.1	1.4	2.6	1.2	-1.6	-1.4	-1.0	1.0	0.9	-1.1	1.0	1.1
Condit. Reinf. active-inactive response ratio	2.1	2.2	2.9	1.5	-1.6	-1.6	-1.4	1.4	1.1	-1.5	1.7	1.4
Condit. Reinf. active responses	0.5	0.8	1.7	0.8	-1.3	-0.9	-0.9	0.9	0.6	-0.8	0.6	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	-0.2	-0.1	0.5	-0.1	0.1	-0.2	0.3	-0.5	-0.2
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.4	0.3	0.6	0.5	-0.5	-0.8	0.5	-0.4	-0.6
Condit. Reinf. lever reinforcers received	0.4	0.6	1.5	0.7	-1.2	-0.8	-0.8	0.8	0.5	-0.7	0.5	0.8
Conditioned reinforcement - actives	0.2	0.2	0.5	-0.7	-0.4	-0.2	-0.5	0.5	0.6	-0.1	0.0	0.6
Conditioned reinforcement - inactives	0.1	0.1	0.2	-0.4	0.5	0.1	0.0	-0.0	-0.1	0.4	-0.2	-0.2
Conditioned locomotion	0.0	0.0	0.2	0.1	-0.2	0.3	-0.1	0.1	0.2	-0.1	0.2	0.4
Patch foraging indifference point 0 sec	1.1	1.8	2.3	-1.4	1.2	1.0	1.5	-1.5	-1.1	1.5	-1.5	-1.2
Patch foraging indifference point AUC	0.1	0.1	0.3	-0.1	0.1	0.1	-0.4	0.4	0.5	-0.4	0.2	0.5
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.3	-0.1	0.3	0.2	-0.2	-0.4	0.2	-0.2	-0.2
Delay disc. indifference point, 16s delay	0.2	0.2	0.6	0.1	0.5	0.8	0.5	-0.5	-0.7	0.1	0.1	-0.5
Delay disc. indifference point, 2s delay	0.6	0.6	2.0	1.3	-1.4	-0.4	-0.8	0.8	0.6	-0.4	0.2	0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	0.4	-0.2	0.1	0.0	-0.0	-0.0	-0.4	0.7	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	0.6	-0.0	0.5	0.0	-0.0	-0.2	-0.3	0.5	0.0
Delay disc. indifference point, 8s delay	0.4	0.4	1.0	1.0	-0.9	-0.4	-0.4	0.4	0.3	-0.6	0.7	0.4
Indifference point function ln k	0.1	0.1	0.3	-0.4	-0.5	-0.3	0.0	-0.0	0.0	0.1	-0.3	-0.0
Indifference point function log k	0.1	0.1	0.3	-0.4	-0.5	-0.3	0.0	-0.0	0.0	0.1	-0.3	-0.0
Patch foraging total patch changes 0 sec	0.9	1.4	2.0	-1.3	0.8	1.0	1.3	-1.3	-1.0	1.4	-1.4	-1.2
Patch foraging total patch changes 12 sec	1.9	2.5	3.0	-1.6	1.6	1.3	1.7	-1.7	-1.3	1.7	-1.7	-1.4
Patch foraging total patch changes 18 sec	0.4	0.5	1.0	-0.6	1.0	0.2	0.8	-0.8	-0.4	0.8	-0.8	-0.6
Patch foraging total patch changes 24 sec	0.2	0.2	0.5	-0.3	0.2	0.2	0.6	-0.6	-0.3	0.7	-0.4	-0.5
Patch foraging total patch changes 6 sec	0.1	0.2	0.5	-0.2	-0.3	0.2	0.5	-0.5	-0.5	0.7	-0.4	-0.6
Patch foraging time to switch 0 sec	0.4	0.6	1.1	0.2	0.9	0.2	0.8	-0.8	-0.9	1.0	-0.4	-1.0
Patch foraging water rate 0 sec	0.1	0.2	0.9	-0.9	-0.5	0.6	0.1	-0.1	0.0	-0.1	-0.3	0.2
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.3	-0.7	0.1	-0.5	0.5	0.4	-0.7	0.7	0.6
Patch foraging water rate 18 sec	0.8	1.1	1.9	1.1	-1.1	-0.4	-1.0	1.0	0.9	-1.2	1.4	1.0
Patch foraging water rate 24 sec	1.6	2.3	4.3	0.6	-2.1	-1.0	-1.5	1.5	1.4	-1.8	1.6	1.7
Patch foraging water rate 6 sec	0.5	0.7	1.5	-1.2	0.4	1.0	0.9	-0.9	-0.8	0.6	-0.7	-0.7
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.8	0.9	-0.4	-0.2	0.1	-0.1	-0.2	0.4	-0.3	-0.5
Distance traveled before self-admin	1.1	1.2	1.7	-0.7	1.3	1.1	1.1	-1.1	-1.1	1.2	-0.9	-1.2
Distance traveled after self-admin	0.1	0.1	0.5	0.2	-0.7	-0.0	-0.2	0.2	0.2	-0.2	0.1	0.2
Extensor digitorum longus weight	0.4	1.6	5.4	-2.3	1.2	0.8	0.9	-0.9	-1.0	1.1	-1.6	-0.8
Bone: elastic displacement	1.5	1.7	2.2	1.0	-0.9	-0.9	-1.5	1.5	1.4	-1.5	1.4	1.5
Bone: elastic work	0.3	0.4	0.6	-0.2	-0.6	-0.2	-0.7	0.7	0.6	-0.7	0.8	0.8
Bone: endosteal estimation	0.2	0.5	0.9	-0.1	-1.0	-0.6	-0.8	0.8	0.7	-0.9	0.4	0.9
Bone: endosteal perimeter	0.1	0.1	0.9	-1.0	0.1	0.4	0.2	-0.2	-0.3	0.0	-0.3	-0.1
Epididymis fat weight	3.8	8.8	11.2	-3.4	2.9	3.3	2.9	-2.9	-2.7	2.7	-3.1	-2.6
Delta time in closed arm before/after self-admin	0.1	0.1	0.5	-0.7	0.4	0.4	0.0	-0.0	-0.1	0.3	-0.5	-0.2
Delta time in open arm before/after self-admin	0.5	0.5	2.7	1.7	-0.7	-0.8	-0.4	0.4	0.5	-0.2	0.5	0.0
Diff in mean of infusions in LGA sessions	0.2	0.2	0.4	0.3	0.3	0.6	0.4	-0.4	-0.6	-0.1	0.1	-0.5
Delay discount exponential model param	0.3	0.4	1.3	-1.1	0.8	0.0	0.3	-0.3	-0.1	0.6	-0.8	-0.3
Extinction: sum of active levers before priming	1.8	1.8	2.4	-1.2	1.5	1.3	1.3	-1.3	-1.4	1.3	-1.2	-1.2
Active lever presses in extinction session 6	2.4	2.4	3.4	-1.8	1.2	1.3	1.5	-1.5	-1.6	1.6	-1.8	-1.4
Bone: final force	0.1	0.1	0.5	-0.4	-0.3	-0.2	-0.3	0.3	0.2	-0.3	0.7	0.4
Bone: final moment	0.1	0.1	0.4	-0.4	-0.2	-0.1	-0.2	0.2	0.2	-0.4	0.6	0.4
Food consumed during 24 hour testing period	1.4	1.7	2.7	1.7	-1.1	-1.3	-1.2	1.2	1.3	-1.4	1.1	1.2
Glucose	0.4	0.6	1.0	-1.0	0.3	0.6	1.0	-1.0	-0.7	0.7	-0.8	-0.8
Heart weight	0.6	0.8	1.9	0.5	-1.1	-0.6	-0.6	0.6	0.8	-1.4	1.2	1.0
Delay discount hyperbolic model param	0.4	0.4	1.4	-1.2	0.9	0.1	0.5	-0.5	-0.2	0.6	-0.8	-0.4
Intermittent access intake day 1-15 change	1.0	1.0	1.8	0.5	-0.8	-1.3	-1.2	1.2	1.1	-0.8	0.6	1.1
Intermittent access intake escalation	1.1	1.1	1.6	0.5	-0.7	-1.3	-1.2	1.2	1.1	-0.8	0.8	1.2
Intermittent access intake escalation 2	0.7	0.7	1.4	0.5	-0.7	-1.2	-0.8	0.8	0.8	-0.9	0.6	0.9
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.8	-0.3	0.7	0.9	0.5	-0.5	-0.6	0.2	0.3	-0.2
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.0	-0.1	0.9	0.9	0.5	-0.5	-0.6	0.8	-0.8	-1.0
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	0.1	-0.1	-0.1	0.0	0.1
Intermittent access day 1 total infusions	1.5	1.8	3.1	1.4	-1.7	-1.4	-1.5	1.5	1.5	-0.7	0.7	1.0
Intermittent access day 15 total infusions	3.3	3.7	5.1	1.6	-2.1	-2.1	-2.3	2.3	2.2	-1.4	1.4	1.8
Intermittent access terminal intake (last 3 days)	2.0	2.2	3.1	1.4	-1.7	-1.7	-1.7	1.7	1.7	-0.9	0.9	1.3
Intermittent access total infusions	2.9	3.3	4.3	1.9	-2.1	-1.9	-2.1	2.1	2.1	-1.1	1.2	1.5
Intermittent access day 1 locomotion	0.7	0.7	1.3	1.1	-1.1	-0.9	-1.0	1.0	0.9	-0.3	0.4	0.6
Intermittent access day 15 total locomotion	2.6	2.8	4.5	1.9	-2.1	-1.6	-1.7	1.7	1.7	-1.3	1.1	1.5
Intermittent access total locomotion	2.0	2.2	3.7	1.9	-1.9	-1.4	-1.6	1.6	1.6	-0.9	0.9	1.2
Intermittent access standard deviation	0.1	0.1	0.2	-0.0	-0.2	-0.3	-0.4	0.4	0.4	-0.2	0.4	0.5
Left kidney weight	1.2	3.4	10.6	-3.3	1.4	2.3	1.6	-1.6	-1.6	1.2	-1.7	-1.0
Right kidney weight	2.1	5.9	18.2	-4.3	2.1	2.6	2.1	-2.1	-2.0	1.8	-2.4	-1.4
Cocaine induced anxiety	0.1	0.2	0.3	-0.2	0.3	0.3	0.4	-0.4	-0.4	0.0	-0.6	-0.5
Post-drug Anxiety	0.5	0.6	1.8	1.3	-0.8	-0.9	-0.5	0.5	0.6	-0.6	0.8	0.3
Baseline Anxiety	0.1	0.1	0.3	0.4	0.4	0.3	0.3	-0.3	-0.3	0.6	0.1	-0.5
Tail length	1.5	4.5	5.8	1.0	-2.2	-2.1	-2.2	2.2	2.2	-2.2	2.4	2.3
Length with tail	0.3	1.2	8.4	-2.9	0.2	1.1	0.5	-0.5	-0.5	0.4	-0.5	-0.1
Length without tail	6.6	14.3	28.4	-5.3	3.1	4.3	3.5	-3.5	-3.6	3.5	-3.8	-3.0
Times rat made contact with spout	1.6	1.8	2.3	0.9	-1.3	-1.2	-1.4	1.4	1.3	-1.5	1.4	1.5
Lifetime Intake	1.6	1.8	2.6	1.4	-1.6	-1.5	-1.6	1.6	1.6	-0.6	0.7	1.0
Liver weight, left	1.2	1.8	5.2	-2.3	1.0	1.6	1.1	-1.1	-0.9	1.2	-1.5	-0.9
Liver weight, right	0.5	0.9	4.7	-2.2	0.7	0.7	0.7	-0.7	-0.5	0.5	-0.8	-0.1
Locomotor activity	0.1	0.1	0.3	-0.5	0.2	0.1	-0.1	0.1	-0.1	-0.5	0.4	0.4
Locomotor testing distance	0.1	0.2	0.8	-0.7	0.9	0.5	0.4	-0.4	-0.5	-0.1	-0.0	-0.0
Locomotor testing rearing	0.0	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1	-0.2	-0.2	0.1
Locomotion in novel chamber	4.9	6.1	7.1	2.2	-1.9	-2.5	-2.7	2.7	2.6	-2.6	2.4	2.6
Locomotion in novel chamber post-restriction	3.7	4.5	6.9	1.2	-1.4	-1.5	-2.3	2.3	2.1	-2.6	2.6	2.4
Fecal boli incidents, locomotor time 1	0.2	0.2	1.0	-1.0	-0.2	0.2	0.5	-0.5	-0.4	0.2	-0.5	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	0.6	0.6	0.5	0.1	-0.1	-0.1	0.1	-0.0	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.6	-0.1	0.5	0.2	0.1	-0.1	-0.1	0.4	-0.7	-0.6
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.1	0.4	-0.2	0.2	-0.2	-0.3	-0.2	0.4	0.1
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.1	0.5	-0.0	0.3	-0.3	-0.4	0.0	0.2	-0.1
Rest time, locomotor task time 1	0.6	0.7	0.9	1.0	-0.4	-0.9	-0.9	0.9	0.8	-0.8	0.8	0.8
Distance moved, locomotor task time 1	0.1	0.1	0.3	-0.6	0.1	0.4	0.1	-0.1	-0.2	0.0	-0.2	0.1
Vertical activity count, locomotor time 1	0.6	0.6	1.5	-1.2	1.0	1.0	0.8	-0.8	-0.7	0.4	-0.4	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.7	-0.7	0.3	0.2	0.3	-0.3	-0.4	0.6	-0.9	-0.5
Bouts of movement, locomotor time 2	0.4	0.4	1.9	-1.4	0.9	0.0	0.3	-0.3	-0.2	0.7	-0.8	-0.2
Total resting periods, locomotor time 2	0.8	0.9	2.5	-1.6	1.3	0.5	0.6	-0.6	-0.6	1.1	-1.1	-0.5
Rest time, locomotor task time 2	0.1	0.1	0.4	0.7	0.1	0.3	-0.0	0.0	-0.0	-0.1	-0.0	-0.2
Distance moved, locomotor task time 2	0.2	0.2	0.7	-0.4	-0.2	-0.3	-0.4	0.4	0.3	-0.4	0.4	0.8
Vertical activity count, locomotor time 2	0.5	0.5	2.2	-1.5	1.2	0.8	0.3	-0.3	-0.5	0.1	0.2	0.3
Light reinforcement 1	0.0	0.1	0.3	0.5	0.3	-0.0	-0.2	0.2	0.3	0.1	-0.0	-0.0
Light reinforcement 2	0.3	0.4	1.5	-0.5	1.2	0.7	0.5	-0.5	-0.4	0.6	-0.4	-0.4
Bone: marrow area	0.3	0.6	1.0	-0.0	-1.0	-0.7	-0.8	0.8	0.7	-0.9	0.4	0.9
Bone: maximum diameter	0.3	0.5	2.6	-1.6	0.5	0.8	0.5	-0.5	-0.6	0.4	-0.5	-0.3
Bone: maximum force	0.1	0.1	0.7	-0.8	-0.1	0.3	0.1	-0.1	-0.2	0.0	0.2	0.0
Bone: maximum moment	0.1	0.1	0.7	-0.8	0.1	0.3	0.1	-0.1	-0.2	-0.0	0.2	0.0
Mean time between licks in bursts	0.2	0.3	0.6	0.7	-0.6	-0.4	-0.6	0.6	0.8	-0.3	0.5	0.6
Mean num. licks in bursts	0.3	0.4	0.8	0.9	-0.7	0.2	-0.6	0.6	0.4	-0.7	0.7	0.3
Cd content in liver	0.3	0.3	0.7	0.6	0.5	-0.2	-0.5	0.5	0.1	-0.7	0.8	0.4
Co content in liver	1.8	2.1	3.2	1.8	-0.7	-1.4	-1.7	1.7	1.5	-1.5	1.0	1.4
Cu content in liver	1.8	2.2	4.0	-2.0	1.6	1.5	1.3	-1.3	-1.7	1.2	-1.4	-1.1
Fe content in liver	8.5	10.2	17.0	-4.1	3.1	3.1	3.1	-3.1	-3.1	3.2	-2.8	-2.7
K content in liver	0.6	0.6	0.9	0.9	-0.5	-0.9	-0.8	0.8	0.7	-0.7	1.0	0.6
Mg content in liver	0.7	0.7	1.4	1.2	-1.1	-0.9	-0.8	0.8	0.7	-0.6	0.8	0.6
Mn content in liver	0.3	0.3	0.9	0.2	-0.4	-0.9	-0.6	0.6	0.7	-0.5	0.5	0.7
Na content in liver	0.3	0.3	2.1	0.2	-1.4	-0.6	-0.1	0.1	0.3	0.0	0.3	0.0
Rb content in liver	1.0	1.3	2.0	-0.0	0.6	1.4	1.1	-1.1	-1.4	1.1	-1.2	-1.4
Se content in liver	3.2	3.9	5.0	-1.9	2.2	2.0	1.9	-1.9	-2.1	2.1	-1.8	-1.9
Sr content in liver	0.6	0.6	1.2	-0.0	0.1	-0.7	-0.8	0.8	0.7	-0.8	1.1	0.9
Zn content in liver	0.8	0.9	2.9	-1.7	1.2	0.7	0.6	-0.6	-0.8	0.7	-0.8	-0.4
Bone: minimum diameter	0.0	0.0	0.1	-0.2	-0.0	0.3	0.1	-0.1	-0.1	-0.3	0.0	0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.6	0.5	0.3	0.3	-0.3	-0.3	0.4	-0.3	-0.2
Time in novel zone, hab. session 1	0.1	0.1	0.1	-0.4	-0.1	0.2	0.3	-0.3	-0.3	0.1	-0.4	-0.2
Total zone transitions, hab. session 1	4.0	5.6	6.5	2.4	-2.5	-2.2	-2.5	2.5	2.3	-2.4	2.1	2.3
Total locomotion distance, hab. session 1	0.9	1.3	2.2	1.5	-1.4	-1.1	-1.2	1.2	1.1	-1.0	0.7	0.9
Locomotion velocity, hab. session 1	1.2	1.6	3.6	1.9	-1.4	-1.3	-1.3	1.3	1.2	-1.1	0.9	0.9
Time in familiar zone, hab. session 2	2.4	2.5	3.5	-1.6	1.4	1.9	1.5	-1.5	-1.4	1.5	-1.7	-1.6
Time in novel zone, hab. session 2	1.1	1.1	1.6	1.2	-1.0	-1.2	-1.0	1.0	0.8	-1.0	1.3	1.0
Total zone transitions, hab. session 2	5.1	6.6	8.0	1.9	-2.5	-2.7	-2.8	2.8	2.5	-2.6	2.3	2.8
Total locomotion distance, hab. session 2	3.3	4.4	5.5	2.0	-2.1	-2.3	-2.2	2.2	2.1	-2.1	1.8	2.0
Locomotion velocity, hab. session 2	3.4	4.6	5.9	2.1	-2.2	-2.4	-2.2	2.2	2.2	-2.1	1.9	2.1
Novel to familiar place preference ratio	0.1	0.1	0.2	0.3	-0.3	-0.1	-0.4	0.4	0.3	-0.3	0.4	0.4
Novelty place preference	0.0	0.0	0.0	0.1	-0.2	0.1	-0.2	0.2	0.1	-0.1	0.1	0.1
Time in novel zone, NPP test	0.0	0.0	0.0	-0.1	-0.1	0.2	-0.1	0.1	-0.0	-0.1	-0.1	0.1
Total zone transitions, NPP test	2.1	3.0	3.8	1.1	-1.7	-1.9	-1.9	1.9	1.8	-1.8	1.3	1.9
Total locomotion distance, NPP test	1.5	2.0	2.6	1.6	-1.4	-1.6	-1.4	1.4	1.4	-1.3	1.2	1.2
Locomotion velocity, NPP test	2.4	3.4	4.3	2.0	-1.9	-2.1	-1.9	1.9	1.8	-1.7	1.6	1.6
Intraocular pressure	0.5	0.7	1.2	-0.9	0.4	1.1	0.8	-0.8	-1.0	0.9	-0.9	-0.9
Delta distance traveled before/after self-admin	2.4	2.6	3.9	1.2	-2.0	-1.3	-1.6	1.6	1.6	-1.7	1.6	1.8
Delta ambulatory time before/after self-admin	1.5	1.6	2.4	1.0	-1.5	-1.0	-1.3	1.3	1.3	-1.4	1.2	1.5
Parametrial fat weight	0.1	0.3	0.6	-0.8	0.7	0.7	0.5	-0.5	-0.4	0.3	-0.0	-0.3
Pavlov. Cond. lever latency	2.6	3.3	6.1	-2.5	1.8	1.9	1.7	-1.7	-1.9	1.6	-1.7	-1.5
Pavlov. Cond. magazine entry latency	3.1	4.0	4.5	2.1	-2.1	-2.1	-1.9	1.9	2.0	-2.0	2.1	1.8
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	0.9	-0.3	-0.4	-0.5	0.5	0.4	-0.4	0.8	0.3
Pavlov. Cond. index score	2.0	2.6	3.8	2.0	-1.7	-1.7	-1.5	1.5	1.7	-1.4	1.7	1.3
Pavlov. Cond. latency score	2.8	3.5	5.1	2.3	-1.9	-2.0	-1.8	1.8	1.9	-1.7	1.9	1.6
Pavlov. Cond. lever contacts	1.7	2.1	5.0	2.2	-1.2	-1.4	-1.3	1.3	1.4	-1.2	1.4	1.0
Pavlov. Cond. magazine entry number	1.8	2.2	3.2	-1.6	1.8	1.6	1.3	-1.3	-1.5	1.4	-1.5	-1.2
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.7	-0.4	0.8	0.8	0.5	-0.5	-0.6	0.4	-0.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.9	1.7	-1.3	-1.5	-1.2	1.2	1.4	-1.2	1.5	1.1
Pavlov. Cond. response bias	1.6	1.9	3.0	1.7	-1.4	-1.4	-1.3	1.3	1.4	-1.3	1.5	1.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.5	0.3	0.0	0.2	-0.2	0.1	0.1	-0.5	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.0	0.1	0.1	0.1	-0.1	-0.3	0.3	0.6	-0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.0	0.0	-0.3	0.0	0.0	0.1
Pavlov. Cond. index score	0.1	0.1	0.3	0.3	-0.3	-0.1	-0.2	0.2	-0.1	-0.0	0.6	0.1
Pavlov. Cond. latency score	0.0	0.1	0.3	0.3	-0.3	-0.0	-0.1	0.1	-0.2	0.1	0.5	-0.0
Pavlov. Cond. lever contacts	0.1	0.2	0.4	0.3	0.3	0.4	0.4	-0.4	-0.6	0.5	-0.2	-0.5
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.1	-0.3	-0.5	-0.3	0.3	0.5	-0.5	-0.2	0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.2	1.0	-1.1	-1.1	-0.8	0.8	1.0	-0.9	0.5	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.3	-0.3	-0.1	-0.2	0.2	-0.0	-0.1	0.6	0.1
Pavlov. Cond. response bias	0.1	0.2	0.4	0.4	0.2	0.4	0.4	-0.4	-0.6	0.6	-0.1	-0.6
Time in closed arm before self-admin	0.2	0.2	0.5	-0.3	-0.6	-0.6	-0.4	0.4	0.5	-0.4	0.1	0.7
Time in closed arm after self-admin	0.4	0.4	0.7	-0.8	-0.7	-0.4	-0.7	0.7	0.7	-0.4	-0.4	0.8
Time in open arm before self-admin	0.1	0.1	0.5	-0.7	0.2	0.6	0.3	-0.3	-0.2	-0.1	-0.0	-0.1
Time in open arm after self-admin	0.1	0.1	0.6	0.8	0.1	0.0	-0.0	0.0	-0.0	0.0	0.4	-0.2
Bone: periosteal estimation	0.1	0.2	1.3	-1.1	-0.0	0.3	0.0	-0.0	-0.1	-0.2	-0.1	0.2
Bone: periosteal perimeter	0.7	1.2	2.9	-1.7	0.9	1.2	1.0	-1.0	-1.0	0.9	-1.0	-0.9
Bone: post-yield work	0.1	0.1	0.3	-0.5	0.5	0.6	0.2	-0.2	-0.3	0.2	-0.1	-0.2
Progressive ratio test 1 active lever presses	0.9	0.9	1.6	0.5	-1.2	-0.9	-1.3	1.3	1.2	-0.5	0.3	1.0
Progressive ratio test 1 breakpoint	1.6	1.6	2.4	0.8	-1.5	-1.2	-1.6	1.6	1.5	-0.9	0.8	1.3
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.5	0.0	-0.7	-0.5	-0.7	0.7	0.6	-0.4	0.6	0.6
Progressive ratio test 2 active lever presses	1.9	2.0	2.6	1.0	-1.6	-1.4	-1.6	1.6	1.5	-1.3	1.4	1.5
Progressive ratio test 2 breakpoint	2.7	3.0	3.8	1.4	-1.9	-1.7	-1.9	1.9	1.8	-1.5	1.8	1.7
Progressive ratio test 2 inactive lever presses	0.4	0.5	1.0	0.3	-0.5	-0.4	-0.7	0.7	0.6	-0.8	1.0	0.7
Incentive Sensitization - Responses	0.8	0.8	1.9	1.0	-0.8	-0.7	-0.8	0.8	0.8	-1.0	1.4	0.8
Incentive Sensitization - Breakpoint	0.9	0.9	2.0	1.0	-0.9	-0.8	-0.8	0.8	0.8	-1.1	1.4	0.8
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.2	-0.2	0.1	0.1	-0.1	-0.1	0.3	-0.1	-0.2
Progressive ratio	0.2	0.3	0.6	0.8	-0.1	-0.6	-0.6	0.6	0.7	-0.3	0.5	0.2
Food seeking constrained by brief footshock	0.1	0.2	0.6	-0.7	0.8	0.1	-0.1	0.1	0.1	0.1	-0.6	0.0
Seeking ratio, punishment vs. effort	0.1	0.1	0.8	-0.9	0.1	0.1	0.1	-0.1	-0.1	0.0	-0.5	0.2
Retroperitoneal fat weight	4.2	13.8	17.0	-3.6	3.2	4.1	3.8	-3.8	-3.7	3.7	-3.6	-3.8
Reaction time number correct	0.1	0.2	0.4	-0.2	-0.1	0.5	-0.4	0.4	0.4	-0.7	0.1	0.6
Reaction time mean minus median	2.1	2.8	5.3	2.3	-2.2	-1.6	-1.5	1.5	1.5	-1.4	1.7	1.1
Reaction time mean minus median AUC	1.8	2.4	5.4	2.3	-2.2	-1.4	-1.3	1.3	1.4	-1.2	1.3	0.8
Reaction time num false alarms	0.3	0.3	0.7	0.4	-0.5	-0.9	-0.6	0.6	0.5	-0.6	0.5	0.5
Reaction time num false alarms AUC	0.0	0.0	0.1	-0.2	0.3	-0.2	-0.0	0.0	-0.1	-0.1	-0.1	-0.1
Reaction time trials correct on left	0.1	0.2	0.4	-0.2	-0.1	0.5	-0.4	0.4	0.4	-0.7	0.1	0.6
Reaction time trials on left	0.1	0.2	0.5	-0.2	-0.2	0.5	-0.5	0.5	0.4	-0.7	0.2	0.6
Reaction time mean	0.4	0.5	2.9	1.7	-0.8	-0.5	-0.3	0.3	0.2	-0.3	0.6	-0.0
Reaction time mean AUC	0.3	0.4	2.5	1.6	-0.7	-0.2	-0.2	0.2	0.2	-0.2	0.5	-0.1
Median of all reaction times	0.1	0.2	1.2	1.1	-0.0	-0.0	0.3	-0.3	-0.4	0.2	0.0	-0.5
Reaction time omissions	0.5	0.6	1.6	1.3	-0.9	-0.8	-0.8	0.8	0.9	-0.5	0.4	0.4
Reaction time false alarm rate	0.1	0.1	0.2	-0.2	0.4	-0.3	0.3	-0.3	-0.4	0.3	-0.2	-0.4
Reaction time premature initiation rate	5.5	7.3	11.6	3.4	-3.1	-2.7	-2.7	2.7	2.6	-2.4	2.4	2.1
Reaction time premature initiations	5.3	7.5	9.7	3.1	-3.1	-2.4	-2.9	2.9	2.7	-2.7	2.4	2.3
Std. dev. reaction times	0.9	1.3	4.1	2.0	-1.5	-0.8	-0.9	0.9	0.9	-0.9	1.2	0.5
Reaction time trials completed	0.1	0.2	0.5	-0.2	-0.2	0.5	-0.5	0.5	0.4	-0.7	0.2	0.6
Reaction time trials AUC	0.1	0.1	0.3	-0.4	0.0	0.6	-0.3	0.3	0.2	-0.5	-0.0	0.4
Run reversals in cocaine runway, females	0.3	0.3	0.5	0.7	-0.3	-0.2	-0.7	0.7	0.6	-0.4	0.6	0.5
Run reversals in cocaine runway, males	0.4	0.4	1.4	-1.2	0.8	0.5	0.2	-0.2	-0.2	0.6	-0.7	-0.2
Latency to leave start box in cocaine runway	3.1	3.4	4.9	-1.2	1.3	1.2	2.0	-2.0	-1.9	2.1	-2.1	-2.2
Latency to leave start box in cocaine runway, F	5.0	5.4	6.8	-2.0	1.8	1.9	2.4	-2.4	-2.4	2.6	-2.6	-2.6
Latency to leave start box in cocaine runway, M	0.6	0.6	1.0	1.0	-0.9	-0.9	-0.5	0.5	0.7	-0.8	0.7	0.5
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.1	-0.0	0.1	0.1	-0.1	0.0	0.2	-0.1	-0.1
Total sessions with >9 infusions	0.3	0.3	0.9	-0.1	-1.0	-0.5	-0.6	0.6	0.6	0.2	-0.0	0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.2	-0.3	-0.3	-0.4	0.4	0.4	0.0	0.4	0.3
Short access day 10 total inactive lever presses	0.2	0.3	1.4	0.6	0.3	-0.1	-0.0	0.0	-0.1	-0.7	1.2	0.3
Short access day 1 total infusions	0.1	0.1	0.4	-0.2	-0.2	-0.3	-0.4	0.4	0.4	0.6	-0.4	-0.0
Short access day 10 total infusions	1.6	1.8	3.0	0.9	-1.7	-1.3	-1.7	1.7	1.7	-0.6	0.4	1.1
Short access total infusions	0.5	0.6	1.1	0.5	-0.9	-0.8	-1.0	1.0	1.0	0.1	0.1	0.5
Short access day 1 locomotion	0.3	0.3	0.7	0.4	-0.5	-0.3	-0.8	0.8	0.8	-0.1	0.3	0.6
Short access day 10 total locomotion	0.2	0.2	0.8	-0.7	0.0	0.2	-0.0	0.0	0.0	0.8	-0.9	-0.1
Short access total locomotion	0.5	0.5	0.9	0.7	-0.9	-0.6	-0.9	0.9	0.9	-0.1	0.1	0.6
One hour access (0.3 mA shock)	2.4	2.9	3.3	1.8	-1.7	-1.7	-1.7	1.7	1.7	-1.4	1.8	1.6
Compulsive drug intake	0.1	0.1	0.5	0.6	-0.1	-0.2	-0.2	0.2	0.1	-0.3	0.7	0.0
One hour access (shock baseline)	1.1	1.3	1.7	1.0	-1.1	-1.1	-1.2	1.2	1.3	-1.0	1.0	1.3
Social response proportion	1.2	1.3	2.6	0.6	-1.6	-0.2	-1.1	1.1	1.1	-1.4	1.2	1.3
Social responses	1.9	2.4	5.0	1.5	-2.2	-1.0	-1.6	1.6	1.4	-1.5	1.6	1.3
Social time	0.1	0.1	0.3	0.3	0.5	0.4	0.2	-0.2	-0.2	0.0	0.2	-0.3
Soleus weight	0.3	0.9	2.9	-1.7	1.0	0.5	0.9	-0.9	-0.8	1.0	-0.8	-0.8
Bone: stiffness	0.0	0.1	0.1	-0.3	-0.3	-0.1	0.2	-0.2	-0.2	0.3	0.2	-0.2
Tibialis anterior weight	0.1	0.4	3.1	-1.8	0.4	-0.2	0.0	-0.0	-0.1	0.1	-0.4	0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.0	-0.1	0.3	0.4	-0.4	-0.5	0.5	0.1	-0.5
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	-0.3	0.5	0.5	0.6	-0.6	-0.4	0.3	-0.2	-0.3
Time to tail flick, test, before self-admin	0.1	0.1	0.7	-0.9	-0.1	-0.0	0.1	-0.1	-0.2	0.3	-0.6	-0.1
Time to tail flick, test, after self-admin	0.4	0.4	1.2	-0.5	0.5	0.6	0.4	-0.4	-0.5	0.8	-1.1	-0.6
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.5	-0.6	1.2	1.0	0.9	-0.9	-0.8	0.6	-1.0	-0.7
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	0.6	0.2	0.2	-0.1	0.1	0.1	-0.1	0.1	-0.0
Tibia length	0.3	0.9	3.3	-1.8	0.5	0.6	0.9	-0.9	-0.7	0.8	-0.8	-0.6
Ambulatory time before self-admin	0.4	0.4	0.9	-0.3	0.9	0.5	0.6	-0.6	-0.5	0.7	-0.5	-0.7
Ambulatory time after self-admin	0.1	0.1	0.5	0.2	-0.7	-0.1	-0.3	0.3	0.3	-0.2	0.1	0.4
Bone: tissue strength	0.5	0.5	1.2	-1.1	0.9	1.1	0.6	-0.6	-0.5	0.2	-0.4	-0.3
Total heroin consumption	0.1	0.1	0.4	0.6	0.1	0.1	0.2	-0.2	-0.2	0.4	0.1	-0.4
Bone: trabecular number	1.2	1.8	6.7	-2.6	1.2	0.9	1.0	-1.0	-1.2	1.3	-1.4	-0.8
Bone: trabecular spacing	0.1	0.2	0.4	0.4	0.3	0.5	0.5	-0.5	-0.3	0.4	-0.2	-0.6
Bone: trabecular thickness	2.3	2.7	6.9	-2.6	1.8	1.2	1.5	-1.5	-1.6	1.5	-1.4	-1.2
Bone: trabecular tissue density	1.6	2.2	3.1	-1.0	1.4	1.8	1.4	-1.4	-1.5	1.7	-1.3	-1.7
Water consumed over 24 hours	1.0	1.1	1.7	0.6	-1.2	-0.9	-1.1	1.1	1.1	-1.3	0.7	1.3
Number of responses in last shaping day	0.1	0.1	0.3	-0.1	-0.4	-0.0	-0.5	0.5	0.5	-0.4	-0.3	0.4