Hub : Genes

Alox5ap

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 LHb gene expression Alox5ap 0.17 0.15 6.1e-03 0.08 0.1 0.07 0.06 5.3e-03 1.9e-03 1.1e-02 1.3e-02
2 NAcc gene expression Alox5ap 0.03 0.01 5.6e-06 0.04 0.04 0.04 0.04 1.6e-06 1.7e-06 7.5e-07 9.0e-07
3 BLA gene expression Alox5ap 0.11 0.06 9.8e-07 0.15 0.1 0.1 0.12 2.9e-08 4.3e-06 6.5e-06 4.7e-07
4 pVTA gene expression Alox5ap 0.2 0.07 0.0e+00 0.29 0.29 0.29 0.3 5.7e-24 6.4e-24 5.9e-24 4.4e-24
5 NAcc intron excision ratio chr12_10794016_10801362 0.03 0.02 1.7e-05 0.03 0.03 0.03 0.03 1.0e-05 4.1e-05 7.4e-05 5.5e-05
6 RMTg intron excision ratio chr12_10794016_10801362 0.13 0.09 6.5e-03 0.04 0.03 -0 0.02 2.8e-02 6.4e-02 3.5e-01 1.2e-01
7 Brain gene expression Alox5ap 0.11 0.06 6.0e-11 0.12 0.12 0.12 0.12 4.8e-11 4.9e-11 4.7e-11 6.6e-11
8 Liver gene expression Alox5ap 0.1 0.05 8.9e-12 0.08 0.07 0.05 0.07 8.1e-09 3.9e-08 1.1e-06 7.1e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density2.54.59.8-3.13.11.9-1.6-1.6-1.61.71.6
Area under the delay curve0.30.41.10.9-1.1-0.70.40.40.3-0.2-0.7
BMI with tail2.17.410.7-3.13.13.3-2.5-2.5-2.52.52.1
BMI without tail0.10.31.1-0.4-0.4-0.10.50.40.4-0.5-1.1
Body weight2.510.931.2-5.64.83.0-2.3-2.3-2.32.41.9
Weight adjusted by age0.30.81.20.4-0.1-0.91.01.01.0-1.0-1.1
Bone surface1.32.66.7-2.62.61.4-1.0-1.0-1.01.21.0
Bone volume2.85.59.9-3.13.12.3-2.0-1.9-1.92.12.0
Breakpoint value in progressive ratio session0.10.20.50.1-0.6-0.60.40.30.3-0.3-0.7
Number of licking bursts0.10.40.7-0.20.0-0.60.70.70.7-0.9-0.6
Context. condit. distance diff. score1.21.52.0-1.31.21.1-1.4-1.1-1.11.41.1
Locomotion velocity, session 10.80.91.30.7-0.8-0.81.11.11.1-0.8-1.0
Locomotion distance, session 12.12.73.51.4-1.3-1.31.81.91.9-1.6-1.8
Locomotion velocity, session 21.61.93.00.7-0.8-1.01.71.61.6-1.7-1.5
Locomotion distance, session 24.05.67.21.6-1.7-2.42.72.62.6-2.6-2.5
Locomotion velocity, session 30.70.81.1-0.80.81.1-0.9-0.8-0.80.90.9
Locomotion distance, session 30.10.10.40.1-0.6-0.40.30.40.4-0.2-0.5
Stereotopy head waving bouts, day 31.01.21.80.8-0.7-0.91.21.41.4-1.2-1.2
Stereotopy head waving duration, day 30.20.20.70.9-0.3-0.30.40.40.4-0.3-0.2
Locomotion velocity, session 70.10.10.50.7-0.40.1-0.2-0.3-0.30.40.2
Locomotion distance, session 70.10.20.70.8-0.6-0.5-0.0-0.1-0.10.0-0.0
Stereotopy head waving bouts, day 72.73.24.01.6-2.0-1.71.81.81.8-1.8-1.7
Stereotopy head waving duration, day 71.21.51.71.1-1.3-1.11.21.31.3-1.2-1.3
Locomotion velocity, session 81.31.61.81.0-1.1-1.31.31.31.3-1.3-1.3
Locomotion distance, session 80.30.40.5-0.10.1-0.70.70.70.7-0.6-0.6
Degree of sensitization distance0.20.20.91.0-0.6-0.50.30.20.2-0.4-0.2
Degree of sensitization stereotypy0.60.71.20.8-1.1-0.60.80.80.8-0.8-0.8
Conditioned locomotion0.50.61.30.9-0.4-1.10.70.60.6-0.9-0.4
Cocaine response after cond. corrected0.40.50.8-0.20.20.8-0.8-0.8-0.80.90.9
Cocaine response after cond. not corrected0.60.91.3-0.40.40.9-1.0-1.1-1.11.11.1
Cocaine response before conditioning0.30.30.5-0.60.60.3-0.6-0.7-0.70.60.6
Saline control response3.44.86.71.4-1.4-2.62.32.42.4-2.2-2.4
Bone: connectivity density0.81.34.8-2.12.20.4-0.4-0.4-0.40.50.5
Bone: cortical apparent density0.40.71.2-0.70.90.8-0.8-0.7-0.70.91.1
Bone: cortical area0.81.42.9-1.71.61.0-1.0-1.0-1.01.00.9
Bone: cortical porosity2.32.53.01.5-1.4-1.41.61.71.7-1.7-1.4
Bone: cortical porosity2.22.42.91.7-1.5-1.61.51.61.6-1.6-1.3
Bone: cortical thickness0.71.22.3-1.51.50.9-0.9-0.9-0.90.90.9
Bone: cortical thickness0.70.81.90.8-0.8-1.40.90.80.8-0.8-0.5
Bone: cortical tissue density0.30.51.0-0.50.80.8-0.7-0.6-0.60.81.0
Condit. Reinf. active minus inactive responses0.91.11.6-1.01.31.3-1.0-1.0-0.91.10.7
Condit. Reinf. active-inactive response ratio1.92.02.8-0.91.31.6-1.5-1.5-1.51.71.2
Condit. Reinf. active responses0.10.10.3-0.40.50.6-0.2-0.2-0.20.30.2
Condit. Reinf. inactive responses0.50.60.80.7-0.9-0.70.90.80.8-0.8-0.6
Incentive salience index mean0.30.40.9-0.60.60.9-0.6-0.5-0.50.60.5
Condit. Reinf. lever presses0.10.10.30.3-0.40.50.10.10.2-0.20.2
Condit. Reinf. active minus inactive responses0.81.22.20.9-1.2-1.51.11.01.1-0.9-1.1
Condit. Reinf. active-inactive response ratio1.11.82.61.2-1.6-1.31.31.21.3-1.1-1.5
Condit. Reinf. active responses0.50.81.80.5-0.7-1.31.00.90.9-0.6-0.8
Condit. Reinf. inactive responses0.00.10.2-0.40.4-0.30.10.20.10.10.2
Condit. Reinf. lever presses0.20.30.7-0.70.40.3-0.5-0.5-0.50.80.5
Condit. Reinf. lever reinforcers received0.40.61.50.3-0.6-1.20.80.80.8-0.5-0.7
Conditioned reinforcement - actives0.10.30.6-0.60.3-0.50.60.60.6-0.8-0.2
Conditioned reinforcement - inactives0.00.10.5-0.70.40.3-0.2-0.2-0.20.10.3
Conditioned locomotion0.00.10.3-0.50.20.0-0.1-0.1-0.1-0.10.3
Patch foraging indifference point 0 sec0.72.13.0-1.61.71.1-1.4-1.5-1.51.11.6
Patch foraging indifference point AUC0.00.00.1-0.20.30.10.10.20.2-0.2-0.3
Delay disc. indifference point, 0s delay0.10.10.2-0.40.4-0.1-0.3-0.2-0.20.30.2
Delay disc. indifference point, 16s delay0.20.20.60.0-0.20.5-0.4-0.6-0.60.80.1
Delay disc. indifference point, 2s delay0.50.61.40.9-0.9-1.20.50.80.7-0.5-0.3
Delay disc. indifference point, 24s delay0.10.10.50.5-0.7-0.2-0.1-0.0-0.10.1-0.4
Delay disc. indifference point, 4s delay0.10.20.70.6-0.80.1-0.1-0.0-0.10.2-0.3
Delay disc. indifference point, 8s delay0.10.20.50.7-0.7-0.70.40.30.2-0.2-0.5
Indifference point function ln k0.00.10.2-0.40.5-0.50.20.10.2-0.2-0.0
Indifference point function log k0.00.10.2-0.40.5-0.50.20.10.2-0.2-0.0
Patch foraging total patch changes 0 sec0.61.72.6-1.41.60.8-1.3-1.4-1.41.01.5
Patch foraging total patch changes 12 sec2.33.13.9-1.82.01.6-1.7-1.8-1.81.51.8
Patch foraging total patch changes 18 sec0.30.60.9-0.31.00.7-0.9-0.9-0.90.50.9
Patch foraging total patch changes 24 sec0.10.40.6-0.50.60.2-0.7-0.8-0.80.40.8
Patch foraging total patch changes 6 sec0.20.40.6-0.60.6-0.0-0.7-0.7-0.70.50.8
Patch foraging time to switch 0 sec0.20.61.20.2-0.50.9-0.8-0.8-0.80.81.1
Patch foraging water rate 0 sec0.10.31.3-1.01.2-0.2-0.2-0.2-0.20.1-0.1
Patch foraging water rate 12 sec0.10.20.5-0.30.1-0.70.40.40.4-0.2-0.7
Patch foraging water rate 18 sec0.71.52.21.3-1.5-1.01.21.11.1-0.9-1.4
Patch foraging water rate 24 sec1.31.82.90.4-0.7-1.71.51.41.5-1.2-1.7
Patch foraging water rate 6 sec0.50.71.2-0.91.10.5-0.8-0.9-0.90.90.6
Seeking ratio, delayed vs. immediate footshock0.10.10.40.2-0.6-0.3-0.1-0.2-0.10.20.5
Distance traveled before self-admin0.40.91.5-0.20.41.1-1.0-1.1-1.11.01.2
Distance traveled after self-admin0.20.40.91.0-0.3-0.90.50.50.5-0.6-0.4
Extensor digitorum longus weight0.51.95.0-1.92.21.2-1.0-1.0-1.00.91.1
Bone: elastic displacement1.51.92.51.2-1.3-0.91.51.61.6-1.4-1.5
Bone: elastic work0.40.50.6-0.60.1-0.70.80.80.8-0.7-0.7
Bone: endosteal estimation0.20.51.2-0.30.0-1.10.70.70.7-0.7-1.0
Bone: endosteal perimeter0.10.31.2-1.10.80.2-0.3-0.3-0.30.30.0
Epididymis fat weight1.67.910.4-2.93.22.9-2.8-2.8-2.82.62.5
Delta time in closed arm before/after self-admin0.10.10.2-0.40.50.3-0.1-0.0-0.00.10.3
Delta time in open arm before/after self-admin0.80.92.41.5-1.6-1.00.60.60.6-0.6-0.4
Diff in mean of infusions in LGA sessions0.20.40.8-0.0-0.40.5-0.7-0.8-0.80.90.2
Delay discount exponential model param0.30.51.5-1.01.20.7-0.3-0.4-0.30.10.7
Extinction: sum of active levers before priming0.91.42.2-1.31.11.5-1.1-1.2-1.21.20.8
Active lever presses in extinction session 61.31.31.9-1.41.40.7-1.1-1.2-1.21.21.1
Bone: final force0.10.20.6-0.30.1-0.80.50.50.5-0.5-0.6
Bone: final moment0.10.20.4-0.30.1-0.60.50.40.5-0.5-0.6
Food consumed during 24 hour testing period0.81.62.11.3-1.4-1.11.21.21.2-1.2-1.4
Glucose0.50.91.2-0.80.80.6-0.9-1.1-1.10.91.0
Heart weight0.10.21.1-1.00.50.20.20.20.2-0.2-0.7
Delay discount hyperbolic model param0.30.41.3-1.01.10.7-0.3-0.4-0.30.10.6
Intermittent access intake day 1-15 change0.10.30.60.30.0-0.30.70.80.7-0.7-0.1
Intermittent access intake escalation0.00.10.30.10.3-0.20.40.50.5-0.50.1
Intermittent access intake escalation 20.00.00.10.30.1-0.10.20.20.2-0.20.1
Intermitt. access day 1 inactive lever presses0.00.51.2-1.10.50.7-0.6-0.7-0.70.70.1
Intermitt. access day 15 inactive lever presses0.10.40.8-0.10.20.8-0.8-0.7-0.70.70.9
Intermitt. access escalation Index0.00.00.1-0.1-0.00.3-0.0-0.1-0.00.2-0.0
Intermittent access day 1 total infusions0.82.23.31.3-1.7-1.81.41.41.4-1.5-1.4
Intermittent access day 15 total infusions0.61.52.30.8-0.9-1.51.31.41.4-1.4-0.9
Intermittent access terminal intake (last 3 days)0.50.81.20.8-0.8-1.10.91.01.0-1.1-0.5
Intermittent access total infusions0.70.91.40.6-1.0-1.20.91.00.9-1.1-0.6
Intermittent access day 1 locomotion0.20.41.00.5-0.6-1.00.60.70.6-0.7-0.4
Intermittent access day 15 total locomotion0.72.54.51.4-1.4-2.11.51.61.6-1.7-1.2
Intermittent access total locomotion1.01.22.30.8-1.0-1.51.01.11.1-1.2-0.7
Intermittent access standard deviation0.10.40.8-0.60.60.7-0.5-0.5-0.50.40.9
Left kidney weight1.310.427.8-5.34.42.5-2.5-2.5-2.52.62.0
Right kidney weight1.712.232.0-5.74.73.1-2.7-2.8-2.82.72.0
Cocaine induced anxiety0.00.10.30.5-0.2-0.30.10.10.1-0.1-0.5
Post-drug Anxiety0.10.10.20.5-0.40.2-0.3-0.4-0.30.30.4
Baseline Anxiety0.61.02.0-0.80.41.0-1.0-1.0-1.01.01.4
Tail length0.63.45.8-0.7-0.6-2.42.01.91.9-2.0-2.4
Length with tail0.62.512.9-3.62.6-0.40.20.20.2-0.1-0.4
Length without tail2.211.427.5-5.25.12.7-2.6-2.5-2.52.62.4
Times rat made contact with spout1.41.62.30.8-0.7-1.21.41.41.4-1.3-1.5
Lifetime Intake0.50.71.10.5-1.0-1.00.80.80.8-1.0-0.4
Liver weight, left0.61.03.4-1.81.80.2-0.6-0.5-0.50.30.3
Liver weight, right0.50.93.8-2.01.60.7-0.3-0.3-0.40.30.2
Locomotor activity0.00.10.2-0.40.3-0.10.10.10.10.1-0.5
Locomotor testing distance0.20.40.7-0.70.80.8-0.5-0.6-0.60.70.2
Locomotor testing rearing0.00.00.10.40.1-0.0-0.0-0.0-0.00.0-0.0
Locomotion in novel chamber7.410.012.52.2-2.4-2.93.53.53.5-3.5-3.4
Locomotion in novel chamber post-restriction1.64.98.00.9-1.9-1.52.52.62.6-2.2-2.8
Fecal boli incidents, locomotor time 10.10.31.1-1.10.80.1-0.5-0.5-0.60.40.2
Change in fecal boli incidents, locomotor task0.10.10.40.2-0.30.6-0.00.00.1-0.0-0.0
Time >=10cm from walls, locomotor time 10.00.10.3-0.50.20.20.10.00.2-0.00.3
Bouts of movement, locomotor time 10.00.00.10.2-0.10.3-0.1-0.0-0.10.1-0.3
Total resting periods, locomotor time 10.00.10.20.0-0.00.4-0.2-0.2-0.20.3-0.1
Rest time, locomotor task time 10.40.70.90.8-0.8-0.80.80.90.9-0.9-0.9
Distance moved, locomotor task time 10.00.00.1-0.20.40.1-0.1-0.2-0.20.20.1
Vertical activity count, locomotor time 10.10.71.2-0.90.91.1-0.7-0.8-0.70.70.4
Time >=10cm from walls, locomotor time 20.10.20.7-0.70.90.2-0.1-0.1-0.10.20.5
Bouts of movement, locomotor time 20.20.61.8-1.31.40.7-0.3-0.3-0.30.20.8
Total resting periods, locomotor time 20.31.12.5-1.61.61.2-0.6-0.6-0.70.51.1
Rest time, locomotor task time 20.00.10.40.2-0.6-0.00.00.10.10.0-0.2
Distance moved, locomotor task time 20.20.20.30.20.4-0.40.60.50.6-0.4-0.5
Vertical activity count, locomotor time 20.10.30.8-0.80.90.9-0.2-0.2-0.10.4-0.1
Light reinforcement 10.00.10.60.8-0.40.3-0.00.10.1-0.30.3
Light reinforcement 20.20.41.3-0.10.31.2-0.6-0.5-0.50.50.7
Bone: marrow area0.20.61.4-0.3-0.0-1.20.80.80.7-0.8-1.0
Bone: maximum diameter0.30.61.9-1.41.20.6-0.5-0.5-0.50.50.4
Bone: maximum force0.10.10.5-0.70.5-0.40.10.20.2-0.1-0.1
Bone: maximum moment0.10.10.4-0.60.5-0.30.20.20.2-0.2-0.2
Mean time between licks in bursts0.10.30.70.8-0.6-0.70.50.50.5-0.6-0.2
Mean num. licks in bursts0.20.51.31.1-0.8-0.50.50.60.6-0.4-0.8
Cd content in liver1.01.12.00.9-1.2-0.41.11.21.1-1.0-1.4
Co content in liver2.12.43.61.9-1.5-1.11.61.61.6-1.6-1.4
Cu content in liver1.01.22.3-0.91.21.5-1.1-0.9-1.01.30.9
Fe content in liver6.27.68.5-2.82.92.8-2.7-2.7-2.72.72.7
K content in liver0.10.10.20.2-0.40.10.30.30.3-0.1-0.2
Mg content in liver0.30.30.90.9-0.9-0.40.40.40.4-0.3-0.3
Mn content in liver0.50.60.80.6-0.5-0.70.90.80.8-0.8-0.9
Na content in liver0.10.10.7-0.80.4-0.3-0.2-0.1-0.20.00.3
Rb content in liver0.50.61.00.8-0.40.5-0.9-0.8-0.81.00.8
Se content in liver4.25.07.4-1.92.22.7-2.2-2.1-2.12.32.3
Sr content in liver0.50.40.7-0.0-0.2-0.20.80.80.8-0.8-0.8
Zn content in liver0.40.51.5-1.21.10.7-0.3-0.2-0.20.40.3
Bone: minimum diameter0.00.00.10.1-0.2-0.20.10.00.0-0.1-0.4
Time in familiar zone, hab. session 10.20.20.7-0.50.80.7-0.3-0.3-0.30.30.4
Time in novel zone, hab. session 10.10.10.1-0.30.1-0.3-0.3-0.3-0.30.30.2
Total zone transitions, hab. session 14.15.86.91.7-2.3-2.62.52.52.5-2.3-2.5
Total locomotion distance, hab. session 11.11.52.11.4-1.4-1.41.21.11.1-1.1-1.0
Locomotion velocity, hab. session 11.42.03.51.8-1.9-1.51.31.21.2-1.2-1.1
Time in familiar zone, hab. session 21.82.12.8-0.91.61.2-1.7-1.5-1.51.41.6
Time in novel zone, hab. session 20.91.01.70.8-1.3-0.81.10.90.9-0.8-1.0
Total zone transitions, hab. session 24.76.17.81.6-1.8-2.32.82.82.8-2.6-2.8
Total locomotion distance, hab. session 23.34.34.81.9-2.0-2.02.22.12.1-2.1-2.1
Locomotion velocity, hab. session 23.34.55.01.9-2.0-2.02.22.22.2-2.2-2.1
Novel to familiar place preference ratio0.10.10.20.1-0.4-0.10.40.40.4-0.3-0.3
Novelty place preference0.00.00.0-0.1-0.20.00.20.20.2-0.0-0.1
Time in novel zone, NPP test0.00.00.1-0.20.00.00.10.10.10.0-0.1
Total zone transitions, NPP test2.13.04.01.0-1.2-1.72.02.02.0-1.9-2.0
Total locomotion distance, NPP test1.62.23.11.4-1.7-1.31.51.51.5-1.4-1.4
Locomotion velocity, NPP test2.53.54.51.8-2.1-1.71.91.91.9-1.9-1.7
Intraocular pressure0.50.81.2-0.80.90.5-0.9-0.9-1.01.10.9
Delta distance traveled before/after self-admin3.23.64.81.6-1.3-2.22.01.91.9-1.9-2.0
Delta ambulatory time before/after self-admin1.42.32.81.6-1.0-1.61.51.61.6-1.5-1.7
Parametrial fat weight1.02.44.2-2.01.51.4-1.5-1.4-1.31.51.6
Pavlov. Cond. lever latency2.53.25.9-2.42.41.2-1.7-1.5-1.51.71.4
Pavlov. Cond. magazine entry latency2.73.44.41.6-2.1-1.91.91.71.7-2.0-1.9
Pavlov. Cond. change in total contacts0.30.31.00.9-1.00.00.40.40.4-0.4-0.3
Pavlov. Cond. index score2.12.64.31.8-2.1-1.41.61.41.4-1.7-1.5
Pavlov. Cond. latency score2.83.65.52.1-2.3-1.61.91.71.7-2.0-1.7
Pavlov. Cond. lever contacts2.42.96.02.4-2.4-1.21.51.31.4-1.6-1.3
Pavlov. Cond. magazine entry number1.82.33.3-1.41.81.6-1.5-1.3-1.31.61.5
Pavlov. Cond. intertrial magazine entries0.20.30.6-0.40.40.8-0.5-0.5-0.50.60.3
Pavlov. Cond. lever-magazine prob. diff.1.62.03.61.7-1.9-1.11.41.21.2-1.5-1.3
Pavlov. Cond. response bias2.02.54.11.7-2.0-1.41.61.31.4-1.6-1.5
Pavlov. Cond. lever latency0.00.00.2-0.30.50.20.0-0.0-0.0-0.2-0.0
Pavlov. Cond. magazine entry latency0.00.00.10.0-0.20.0-0.1-0.1-0.10.10.3
Pavlov. Cond. change in total contacts0.00.00.0-0.10.0-0.10.10.20.20.0-0.1
Pavlov. Cond. index score0.10.10.30.3-0.5-0.30.20.20.3-0.1-0.1
Pavlov. Cond. latency score0.00.10.20.2-0.4-0.40.20.20.2-0.1-0.1
Pavlov. Cond. lever contacts0.10.10.20.2-0.40.1-0.3-0.2-0.20.40.3
Pavlov. Cond. magazine entry number0.00.10.20.10.1-0.10.30.20.2-0.2-0.5
Pavlov. Cond. intertrial magazine entries0.20.51.20.4-0.6-1.10.80.70.6-0.7-0.8
Pavlov. Cond. lever-magazine prob. diff.0.00.10.20.2-0.5-0.30.20.20.3-0.1-0.1
Pavlov. Cond. response bias0.10.10.30.3-0.50.1-0.3-0.3-0.20.40.4
Time in closed arm before self-admin0.30.40.7-0.30.4-0.70.80.70.7-0.7-0.8
Time in closed arm after self-admin0.80.91.2-0.50.8-1.01.01.11.1-1.1-0.9
Time in open arm before self-admin0.00.00.1-0.20.10.1-0.2-0.3-0.30.10.1
Time in open arm after self-admin0.40.41.81.2-1.3-0.20.10.20.2-0.1-0.2
Bone: periosteal estimation0.10.20.9-1.00.7-0.30.10.10.1-0.1-0.3
Bone: periosteal perimeter0.61.22.3-1.51.40.8-1.0-1.0-1.00.90.8
Bone: post-yield work0.10.10.4-0.20.60.5-0.3-0.2-0.20.20.3
Progressive ratio test 1 active lever presses0.50.91.40.3-0.6-1.11.01.11.1-1.2-0.8
Progressive ratio test 1 breakpoint0.50.91.30.3-0.6-1.11.01.11.1-1.1-0.8
Progressive ratio test 1 inactive lever presses0.10.20.4-0.1-0.5-0.60.30.30.3-0.3-0.6
Progressive ratio test 2 active lever presses0.60.81.4-0.3-0.7-1.21.01.00.9-1.0-1.0
Progressive ratio test 2 breakpoint0.60.81.3-0.3-0.7-1.10.90.90.9-1.0-1.0
Progressive ratio test 2 inactive lever presses0.10.30.7-0.7-0.5-0.50.50.50.5-0.5-0.9
Incentive Sensitization - Responses0.10.10.5-0.7-0.50.00.30.20.1-0.1-0.5
Incentive Sensitization - Breakpoint0.10.10.4-0.6-0.6-0.00.30.20.2-0.2-0.5
Sum of active levers in priming session hrs 5-60.20.20.6-0.80.7-0.2-0.2-0.3-0.30.10.3
Progressive ratio0.10.30.60.4-0.7-0.10.70.70.8-0.7-0.1
Food seeking constrained by brief footshock0.20.31.1-0.21.10.9-0.2-0.1-0.10.30.3
Seeking ratio, punishment vs. effort0.10.10.8-0.30.9-0.1-0.0-0.0-0.10.1-0.2
Retroperitoneal fat weight2.310.313.3-3.63.52.4-3.2-3.2-3.13.23.3
Reaction time number correct0.10.20.5-0.70.3-0.20.40.40.4-0.4-0.6
Reaction time mean minus median0.53.55.52.3-2.4-2.31.61.51.5-1.6-1.5
Reaction time mean minus median AUC0.53.35.82.2-2.3-2.41.41.41.4-1.5-1.3
Reaction time num false alarms0.10.30.50.2-0.3-0.60.50.70.6-0.4-0.6
Reaction time num false alarms AUC0.00.00.1-0.20.30.1-0.00.10.00.2-0.1
Reaction time trials correct on left0.10.20.5-0.70.3-0.20.40.40.4-0.4-0.6
Reaction time trials on left0.10.20.4-0.60.3-0.30.40.50.5-0.4-0.6
Reaction time mean0.51.03.92.0-1.8-0.70.30.30.3-0.3-0.4
Reaction time mean AUC0.40.93.82.0-1.7-0.60.30.30.3-0.2-0.3
Median of all reaction times0.30.52.31.5-1.20.1-0.3-0.3-0.20.30.2
Reaction time omissions0.30.61.71.3-0.7-0.80.60.60.6-0.7-0.3
Reaction time false alarm rate0.10.10.2-0.00.30.3-0.3-0.2-0.30.40.3
Reaction time premature initiation rate4.77.29.82.8-2.9-3.12.62.72.7-2.5-2.2
Reaction time premature initiations2.47.29.72.4-2.6-3.12.72.82.8-2.5-2.5
Std. dev. reaction times0.62.04.52.0-2.1-1.71.00.91.0-1.0-1.0
Reaction time trials completed0.10.20.4-0.60.3-0.30.40.50.5-0.4-0.6
Reaction time trials AUC0.00.20.6-0.80.4-0.10.30.30.3-0.2-0.4
Run reversals in cocaine runway, females0.20.20.91.0-0.7-0.10.30.40.3-0.3-0.2
Run reversals in cocaine runway, males0.20.21.2-0.41.10.2-0.20.10.10.10.4
Latency to leave start box in cocaine runway3.14.25.9-1.42.11.5-2.1-2.3-2.22.22.4
Latency to leave start box in cocaine runway, F4.55.66.9-2.02.61.9-2.3-2.5-2.52.42.6
Latency to leave start box in cocaine runway, M0.10.10.40.3-0.1-0.70.20.10.2-0.2-0.0
Std. dev. time between licks in bursts0.00.00.1-0.20.2-0.3-0.0-0.0-0.0-0.10.1
Total sessions with >9 infusions0.10.10.3-0.20.2-0.30.10.20.2-0.30.5
Short access day 1 total inactive lever presses0.10.21.0-1.00.40.1-0.2-0.2-0.20.20.4
Short access day 10 total inactive lever presses0.10.81.1-0.90.50.9-0.9-1.0-1.01.10.4
Short access day 1 total infusions0.10.10.20.0-0.1-0.30.30.40.4-0.50.2
Short access day 10 total infusions0.40.71.10.6-0.7-1.00.80.90.9-1.0-0.6
Short access total infusions0.20.30.40.3-0.6-0.60.50.50.5-0.70.0
Short access day 1 locomotion0.10.20.40.2-0.2-0.20.40.60.5-0.6-0.2
Short access day 10 total locomotion0.10.41.3-1.01.10.3-0.4-0.3-0.40.30.6
Short access total locomotion0.00.10.10.1-0.2-0.30.20.20.2-0.40.1
One hour access (0.3 mA shock)2.42.93.41.2-1.8-1.81.71.71.7-1.8-1.6
Compulsive drug intake0.50.82.21.5-1.0-0.80.70.70.7-0.5-0.7
One hour access (shock baseline)0.20.50.80.0-0.9-0.70.70.70.7-0.9-0.9
Social response proportion1.01.22.00.6-1.0-1.41.11.11.1-1.1-1.4
Social responses2.22.95.31.5-1.8-2.31.61.61.6-1.5-1.6
Social time0.20.21.00.8-1.00.4-0.1-0.1-0.10.1-0.1
Soleus weight0.31.02.1-1.31.51.0-0.8-0.8-0.70.70.9
Bone: stiffness0.00.10.3-0.50.1-0.5-0.1-0.2-0.10.00.1
Tibialis anterior weight0.20.62.5-1.51.60.10.00.10.1-0.1-0.1
Time to tail flick, vehicle, before self-admin0.40.61.0-0.50.40.4-0.9-0.8-0.81.00.9
Time to tail flick, vehicle, after self-admin0.30.71.6-1.30.80.7-0.7-0.8-0.80.70.8
Time to tail flick, test, before self-admin0.30.41.6-1.31.1-0.50.20.10.1-0.00.1
Time to tail flick, test, after self-admin0.30.40.7-0.40.80.5-0.6-0.5-0.50.60.8
Delta time to tail flick, vehicle, before/after SA1.11.21.9-1.21.11.4-1.0-1.0-1.01.00.9
Delta time to tail flick, test, before/after SA0.10.20.91.0-0.60.30.00.10.1-0.1-0.0
Tibia length0.51.45.3-2.31.80.4-0.6-0.7-0.70.50.6
Ambulatory time before self-admin0.10.30.7-0.00.20.7-0.6-0.7-0.70.60.8
Ambulatory time after self-admin0.30.51.11.0-0.2-0.90.60.70.7-0.6-0.5
Bone: tissue strength0.50.51.4-1.11.20.8-0.5-0.5-0.50.40.2
Total heroin consumption0.20.21.00.8-1.00.00.10.00.00.0-0.1
Bone: trabecular number1.12.15.7-2.32.41.2-0.9-0.9-0.91.01.1
Bone: trabecular spacing0.20.30.50.0-0.20.5-0.7-0.7-0.70.50.6
Bone: trabecular thickness2.23.16.1-2.42.51.6-1.4-1.4-1.41.51.4
Bone: trabecular tissue density1.22.13.3-1.51.21.3-1.5-1.3-1.31.61.8
Water consumed over 24 hours0.91.72.60.4-0.7-1.41.51.51.5-1.4-1.6
Number of responses in last shaping day0.00.10.2-0.10.40.2-0.3-0.2-0.20.10.3