Hub : Genes

Alb

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Alb 0.19 0.09 3.1e-07 0.15 0.19 0.13 0.2 5.7e-07 1.3e-08 2.2e-06 6.1e-09
2 Brain gene expression Alb 0.25 0.03 0.0e+00 0.47 0.5 0.5 0.5 3.8e-48 1.4e-52 2.2e-52 6.0e-53
3 NAcc gene expression Alb 0.31 0.09 0.0e+00 0.38 0.41 0.39 0.42 6.1e-46 2.5e-51 1.3e-48 2.1e-52
4 BLA gene expression Alb 0.28 0.1 1.1e-16 0.29 0.3 0.28 0.33 9.0e-16 1.4e-16 4.0e-15 1.5e-18
5 Liver mRNA stability Alb 0.33 0.11 0.0e+00 0.36 0.37 0.35 0.36 1.1e-41 1.8e-43 1.6e-40 1.1e-41
6 OFC gene expression Alb 0.59 0.14 5.7e-12 0.26 0.42 0.39 0.39 5.5e-07 4.0e-11 2.8e-10 2.8e-10
7 PL mRNA stability Alb 0.03 0.02 4.8e-03 0.01 0.03 0.01 0.01 1.2e-02 7.8e-04 2.4e-02 7.6e-03
8 IL gene expression Alb 0.57 0.12 3.4e-14 0.31 0.5 0.43 0.47 4.3e-08 9.0e-14 1.5e-11 6.3e-13
9 PL gene expression Alb 0.52 0.11 0.0e+00 0.43 0.54 0.56 0.57 1.6e-51 5.0e-70 4.6e-74 1.2e-75
10 LHb gene expression Alb 0.59 0.14 5.2e-09 0.29 0.29 0.3 0.3 1.1e-07 1.0e-07 7.4e-08 7.5e-08
11 Adipose gene expression Alb 0.68 0.11 0.0e+00 0.5 0.49 0.49 0.5 2.2e-63 1.3e-62 4.7e-62 1.5e-63
12 Adipose mRNA stability Alb 0.05 0.03 7.8e-05 0.02 0.02 0.02 0.01 1.6e-03 2.3e-03 5.1e-03 1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density2.13.55.2-2.0-2.0-2.0-2.01.8-1.9-1.6-1.8-1.62.31.4-1.8
Area under the delay curve0.40.41.9-0.1-0.1-0.2-0.20.4-0.4-0.5-0.4-0.8-0.2-1.11.4
BMI with tail2.06.69.7-3.1-3.1-3.1-3.12.7-2.2-2.5-2.2-2.32.52.0-1.1
BMI without tail0.30.51.3-0.9-0.8-0.9-0.80.5-0.3-0.4-0.3-0.40.71.0-1.1
Body weight0.41.93.21.31.31.21.2-1.21.61.31.71.6-1.20.7-1.8
Weight adjusted by age0.10.10.3-0.2-0.2-0.2-0.20.2-0.20.1-0.1-0.20.60.5-0.5
Bone surface0.51.05.5-0.6-0.7-0.7-0.70.4-0.4-0.2-0.40.01.11.6-2.3
Bone volume0.71.23.1-1.0-1.0-1.0-1.01.0-1.0-0.8-0.9-0.61.31.2-1.8
Breakpoint value in progressive ratio session0.10.10.50.20.30.20.2-0.30.30.30.30.4-0.10.4-0.7
Number of licking bursts1.01.11.81.21.21.21.2-1.11.21.01.21.0-1.3-0.50.2
Context. condit. distance diff. score2.73.25.9-1.6-1.6-1.6-1.62.1-2.2-2.4-2.3-2.31.1-1.00.9
Locomotion velocity, session 10.80.82.1-0.7-0.7-0.7-0.71.3-1.2-1.5-1.2-1.00.5-0.30.4
Locomotion distance, session 12.12.75.0-1.4-1.4-1.4-1.42.0-2.1-2.2-2.0-1.91.1-0.61.1
Locomotion velocity, session 20.30.31.5-0.4-0.4-0.3-0.21.0-0.7-1.2-0.7-0.4-0.10.10.1
Locomotion distance, session 20.60.82.8-0.4-0.4-0.3-0.31.0-1.0-1.3-1.0-0.9-0.1-1.01.7
Locomotion velocity, session 31.01.12.5-0.7-0.7-0.7-0.71.3-1.4-1.6-1.4-1.30.5-1.00.5
Locomotion distance, session 32.73.05.6-1.6-1.6-1.6-1.62.1-2.2-2.4-2.1-2.01.2-0.50.6
Stereotopy head waving bouts, day 30.20.20.90.20.20.20.20.3-0.4-0.4-0.3-0.3-0.4-0.81.0
Stereotopy head waving duration, day 30.20.20.7-0.1-0.1-0.1-0.10.2-0.6-0.3-0.6-0.60.2-0.80.5
Locomotion velocity, session 70.70.81.3-0.6-0.6-0.6-0.60.8-1.1-1.0-1.1-1.10.6-0.91.0
Locomotion distance, session 70.40.50.9-0.5-0.6-0.5-0.50.7-0.9-0.7-0.9-0.80.6-0.60.9
Stereotopy head waving bouts, day 70.50.60.8-0.7-0.7-0.7-0.80.9-0.8-0.9-0.8-0.60.80.4-0.7
Stereotopy head waving duration, day 70.10.10.1-0.2-0.1-0.2-0.20.4-0.3-0.4-0.3-0.30.2-0.10.1
Locomotion velocity, session 85.97.110.4-2.7-2.7-2.7-2.72.9-3.1-3.1-3.2-3.22.3-0.71.2
Locomotion distance, session 83.95.710.3-2.2-2.2-2.2-2.22.8-2.9-3.2-3.0-2.91.6-1.01.4
Degree of sensitization distance1.21.22.71.01.01.01.0-1.51.41.61.41.2-0.80.10.0
Degree of sensitization stereotypy0.00.00.1-0.1-0.0-0.1-0.10.2-0.0-0.20.00.10.00.2-0.3
Conditioned locomotion0.20.20.8-0.4-0.3-0.3-0.4-0.1-0.30.3-0.4-0.50.9-0.60.7
Cocaine response after cond. corrected0.20.20.50.40.30.40.4-0.60.40.70.50.4-0.1-0.1-0.3
Cocaine response after cond. not corrected0.20.21.5-0.2-0.3-0.2-0.2-0.0-0.00.20.00.10.60.8-1.2
Cocaine response before conditioning1.11.33.3-1.1-1.2-1.1-1.11.0-0.8-0.8-0.7-0.51.31.7-1.8
Saline control response0.60.81.1-1.0-1.0-1.0-1.01.0-1.0-0.9-1.0-0.81.00.5-0.4
Bone: connectivity density2.33.65.6-2.1-2.1-2.1-2.11.9-2.0-1.7-2.0-1.82.41.0-1.3
Bone: cortical apparent density0.30.41.0-0.5-0.5-0.5-0.50.8-0.8-1.0-0.7-0.70.0-0.50.9
Bone: cortical area1.11.73.2-1.4-1.3-1.4-1.41.1-1.2-0.9-1.1-0.91.71.2-1.8
Bone: cortical porosity0.10.10.3-0.1-0.1-0.1-0.1-0.2-0.00.3-0.1-0.20.5-0.3-0.3
Bone: cortical porosity0.10.10.4-0.1-0.1-0.1-0.1-0.30.10.40.0-0.00.5-0.0-0.6
Bone: cortical thickness3.65.98.3-2.8-2.7-2.8-2.82.5-2.4-2.1-2.4-2.12.91.8-1.6
Bone: cortical thickness0.60.72.2-0.8-0.7-0.9-0.80.5-0.4-0.2-0.3-0.21.01.3-1.5
Bone: cortical tissue density0.30.30.9-0.4-0.4-0.4-0.40.8-0.7-0.9-0.6-0.6-0.1-0.40.9
Condit. Reinf. active minus inactive responses0.80.91.71.11.11.11.1-0.70.90.61.01.1-1.3-0.40.1
Condit. Reinf. active-inactive response ratio1.01.11.71.21.21.21.2-0.91.00.81.11.2-1.3-0.30.6
Condit. Reinf. active responses0.20.20.70.60.60.60.6-0.10.2-0.10.30.5-0.8-0.50.3
Condit. Reinf. inactive responses0.20.20.6-0.4-0.4-0.4-0.40.6-0.6-0.8-0.6-0.40.30.1-0.5
Incentive salience index mean0.00.10.20.20.20.20.20.00.0-0.20.00.1-0.4-0.50.3
Condit. Reinf. lever presses0.50.61.0-0.9-0.9-0.9-0.90.8-0.9-0.7-0.9-0.81.00.20.0
Condit. Reinf. active minus inactive responses0.30.41.2-0.5-0.4-0.5-0.50.9-0.7-1.1-0.6-0.50.10.6-0.0
Condit. Reinf. active-inactive response ratio0.80.93.00.50.60.50.6-0.60.80.80.91.1-0.21.6-1.7
Condit. Reinf. active responses0.20.31.3-0.1-0.2-0.1-0.10.8-0.6-1.1-0.6-0.5-0.4-0.20.7
Condit. Reinf. inactive responses0.70.83.1-0.4-0.5-0.4-0.40.9-0.9-1.2-0.9-1.0-0.2-1.21.8
Condit. Reinf. lever presses0.40.50.90.80.80.80.8-0.80.80.60.70.5-1.0-0.60.2
Condit. Reinf. lever reinforcers received0.30.41.4-0.2-0.2-0.2-0.20.9-0.7-1.2-0.6-0.6-0.4-0.20.8
Conditioned reinforcement - actives0.60.61.90.90.90.90.9-0.40.50.10.50.4-1.1-0.91.4
Conditioned reinforcement - inactives0.60.71.10.80.80.80.7-1.00.91.11.00.8-0.30.6-1.0
Conditioned locomotion2.83.44.92.22.22.22.2-1.91.71.71.71.5-2.0-1.50.9
Patch foraging indifference point 0 sec0.40.71.6-0.6-0.7-0.7-0.80.9-0.9-1.3-1.0-1.20.4-0.4-0.0
Patch foraging indifference point AUC0.10.21.10.30.40.20.2-0.5-0.00.5-0.1-0.10.2-1.0-0.2
Delay disc. indifference point, 0s delay0.10.10.30.10.10.20.20.2-0.1-0.5-0.0-0.1-0.5-0.10.5
Delay disc. indifference point, 16s delay0.40.41.0-0.5-0.4-0.5-0.50.6-0.4-0.8-0.6-0.9-0.0-0.71.0
Delay disc. indifference point, 2s delay0.20.31.50.30.40.40.4-0.20.00.1-0.0-0.2-0.3-1.20.9
Delay disc. indifference point, 24s delay0.90.83.11.11.10.90.7-0.60.40.40.4-0.1-1.2-1.80.9
Delay disc. indifference point, 4s delay1.21.24.7-0.4-0.4-0.4-0.40.9-1.0-1.2-1.0-1.2-0.0-1.82.2
Delay disc. indifference point, 8s delay0.40.41.0-0.6-0.6-0.6-0.60.7-0.7-0.6-0.6-0.70.5-0.31.0
Indifference point function ln k0.20.31.6-0.6-0.6-0.5-0.40.6-0.1-0.7-0.1-0.2-0.11.3-0.4
Indifference point function log k0.20.31.6-0.6-0.6-0.5-0.40.6-0.1-0.7-0.1-0.2-0.11.3-0.4
Patch foraging total patch changes 0 sec0.40.61.5-0.6-0.7-0.7-0.70.8-0.9-1.2-1.0-1.20.4-0.50.0
Patch foraging total patch changes 12 sec0.60.72.7-0.2-0.2-0.4-0.50.5-0.7-0.8-0.8-1.1-0.1-1.41.6
Patch foraging total patch changes 18 sec0.20.20.40.70.60.60.6-0.30.30.10.30.4-0.6-0.2-0.5
Patch foraging total patch changes 24 sec0.91.13.1-0.4-0.4-0.4-0.50.8-1.1-1.4-1.2-1.40.0-1.51.8
Patch foraging total patch changes 6 sec0.71.02.8-0.6-0.6-0.8-0.80.6-1.0-0.9-1.1-1.50.5-1.71.1
Patch foraging time to switch 0 sec0.10.21.2-0.3-0.3-0.4-0.40.5-0.2-0.4-0.10.00.21.10.4
Patch foraging water rate 0 sec0.20.30.80.30.30.40.4-0.70.40.60.30.00.0-0.9-0.9
Patch foraging water rate 12 sec0.30.41.1-0.5-0.5-0.5-0.50.2-0.7-0.3-0.7-0.90.9-1.10.1
Patch foraging water rate 18 sec0.10.10.30.20.20.30.4-0.20.2-0.10.20.1-0.5-0.50.2
Patch foraging water rate 24 sec0.81.11.61.21.21.21.3-1.01.11.01.11.2-1.1-0.3-0.4
Patch foraging water rate 6 sec0.50.73.40.80.80.80.8-0.80.50.50.40.1-0.8-1.80.5
Seeking ratio, delayed vs. immediate footshock0.20.21.60.40.40.40.4-0.30.10.10.0-0.1-0.5-1.30.6
Distance traveled before self-admin2.22.43.51.81.71.81.8-1.61.51.31.41.1-1.9-1.21.0
Distance traveled after self-admin4.44.99.12.42.32.52.6-1.81.81.31.81.7-3.0-2.12.8
Extensor digitorum longus weight7.027.737.2-6.1-6.0-6.1-6.15.4-4.8-4.5-4.7-4.25.95.2-3.1
Bone: elastic displacement2.02.24.0-1.7-1.7-1.7-1.71.5-1.2-1.1-1.1-0.91.72.0-1.2
Bone: elastic work1.92.44.4-1.7-1.8-1.7-1.81.4-1.2-1.0-1.0-0.81.92.1-1.7
Bone: endosteal estimation1.83.95.12.22.22.32.3-2.12.12.02.12.2-2.0-0.5-0.6
Bone: endosteal perimeter0.91.92.71.41.51.41.4-1.51.41.61.41.6-0.90.2-1.3
Epididymis fat weight0.30.61.90.70.70.70.8-0.60.60.60.60.4-1.1-0.91.4
Delta time in closed arm before/after self-admin0.10.10.2-0.3-0.3-0.3-0.30.3-0.3-0.2-0.4-0.20.40.3-0.5
Delta time in open arm before/after self-admin0.70.71.90.80.70.60.5-0.80.80.80.60.2-0.9-1.11.4
Diff in mean of infusions in LGA sessions0.70.81.80.70.70.60.6-0.60.90.91.01.2-0.61.4-0.9
Delay discount exponential model param0.40.42.00.1-0.00.10.1-0.30.30.40.40.80.21.3-1.4
Extinction: sum of active levers before priming0.40.41.40.60.70.60.6-0.70.30.40.20.1-0.5-1.20.8
Active lever presses in extinction session 62.32.22.91.61.61.61.7-1.61.71.51.71.6-1.7-0.2-0.4
Bone: final force0.30.62.10.60.50.60.6-0.80.71.00.70.9-0.10.4-1.5
Bone: final moment0.50.81.60.90.80.90.9-1.00.91.21.01.1-0.50.2-1.2
Food consumed during 24 hour testing period0.50.60.9-0.9-0.9-0.9-1.00.7-0.8-0.6-0.8-0.91.00.20.5
Glucose0.60.92.21.11.11.11.1-0.70.70.40.70.6-1.5-1.00.8
Heart weight0.30.41.90.30.20.20.2-0.70.70.80.60.30.00.3-1.4
Delay discount hyperbolic model param0.60.62.70.20.10.20.2-0.40.60.60.61.00.11.5-1.7
Intermittent access intake day 1-15 change0.30.30.50.60.60.50.5-0.30.70.30.70.6-0.60.20.1
Intermittent access intake escalation1.11.11.71.21.21.21.1-0.81.30.71.31.1-1.3-0.00.5
Intermittent access intake escalation 23.43.34.52.12.12.12.0-1.82.01.72.01.9-2.0-0.50.8
Intermitt. access day 1 inactive lever presses5.45.87.2-2.6-2.7-2.6-2.72.6-2.6-2.6-2.6-2.72.50.4-0.1
Intermitt. access day 15 inactive lever presses0.60.73.40.10.10.0-0.0-0.60.71.00.70.70.61.3-1.9
Intermitt. access escalation Index0.70.62.30.40.40.50.5-0.50.70.70.81.2-0.61.5-0.7
Intermittent access day 1 total infusions0.91.11.81.21.21.21.1-1.30.91.00.80.6-1.0-1.3-0.4
Intermittent access day 15 total infusions2.62.94.32.12.02.01.9-1.71.81.41.71.4-2.0-1.40.4
Intermittent access terminal intake (last 3 days)5.05.47.62.82.82.72.6-2.52.42.22.32.0-2.5-1.60.4
Intermittent access total infusions2.83.14.32.12.12.02.0-2.01.81.81.71.4-1.8-1.50.2
Intermittent access day 1 locomotion0.80.81.31.11.11.11.1-1.00.80.80.80.6-0.9-0.9-0.5
Intermittent access day 15 total locomotion1.71.85.81.51.41.51.4-1.11.00.50.80.1-1.7-2.41.3
Intermittent access total locomotion2.42.84.12.01.91.91.9-1.71.71.41.61.2-2.0-1.50.7
Intermittent access standard deviation0.20.21.50.40.40.30.3-0.20.1-0.00.0-0.3-0.3-1.2-0.0
Left kidney weight1.23.25.51.71.81.71.8-2.32.22.32.01.5-1.3-0.8-1.5
Right kidney weight1.95.39.12.42.42.42.3-2.92.73.02.62.1-1.6-0.8-1.2
Cocaine induced anxiety1.31.53.51.11.11.11.1-0.91.21.31.41.9-0.91.5-0.7
Post-drug Anxiety0.80.91.71.01.01.01.1-0.70.90.81.01.3-1.20.40.4
Baseline Anxiety1.21.27.4-0.3-0.3-0.3-0.30.7-0.9-1.0-1.0-1.1-0.3-1.62.7
Tail length3.29.812.83.63.63.53.5-3.43.33.43.43.4-3.1-0.6-0.8
Length with tail4.917.824.75.04.94.94.8-4.54.44.24.44.2-4.5-1.7-0.5
Length without tail2.04.57.02.62.52.52.5-1.91.91.61.91.7-2.7-1.81.1
Times rat made contact with spout0.30.41.5-0.7-0.7-0.7-0.7-0.1-0.30.4-0.4-0.61.20.30.0
Lifetime Intake2.12.43.41.81.81.81.7-1.81.51.71.41.3-1.4-1.4-0.1
Liver weight, left0.20.31.5-0.1-0.0-0.1-0.10.1-0.5-0.3-0.5-0.6-0.0-1.21.2
Liver weight, right0.30.53.10.10.10.10.1-0.1-0.4-0.0-0.5-0.70.1-1.81.4
Locomotor activity0.00.00.20.10.00.0-0.0-0.0-0.1-0.1-0.1-0.4-0.1-0.5-0.1
Locomotor testing distance0.71.22.7-1.1-1.1-1.1-1.11.1-1.2-1.3-1.3-1.60.8-0.60.5
Locomotor testing rearing0.30.51.2-0.5-0.6-0.5-0.50.8-0.9-1.1-0.9-1.00.2-0.6-0.2
Locomotion in novel chamber0.40.52.3-0.3-0.3-0.3-0.30.5-0.6-0.7-0.6-0.9-0.2-1.51.1
Locomotion in novel chamber post-restriction0.50.61.50.70.80.70.7-0.80.80.40.60.1-1.1-1.2-0.0
Fecal boli incidents, locomotor time 10.20.20.7-0.1-0.10.00.1-0.40.30.80.30.30.60.7-0.6
Change in fecal boli incidents, locomotor task1.00.91.41.21.21.00.9-0.91.10.91.11.2-1.10.2-0.6
Time >=10cm from walls, locomotor time 10.60.61.20.70.70.50.4-0.70.81.00.90.9-0.41.1-1.0
Bouts of movement, locomotor time 10.20.20.40.60.60.30.2-0.60.50.50.40.0-0.6-0.4-0.1
Total resting periods, locomotor time 10.40.50.80.90.90.60.5-0.80.70.80.70.4-0.8-0.50.4
Rest time, locomotor task time 10.60.71.01.01.00.90.8-1.00.91.00.90.8-0.70.10.1
Distance moved, locomotor task time 10.10.10.3-0.4-0.4-0.3-0.10.2-0.3-0.2-0.3-0.20.5-0.10.2
Vertical activity count, locomotor time 10.40.41.30.60.60.60.7-0.40.40.10.40.1-1.0-1.20.7
Time >=10cm from walls, locomotor time 20.30.31.1-0.2-0.2-0.5-0.60.3-0.30.0-0.2-0.10.71.0-1.0
Bouts of movement, locomotor time 20.60.62.70.80.70.60.5-0.20.1-0.20.0-0.2-0.9-1.61.4
Total resting periods, locomotor time 20.50.52.10.90.80.70.6-0.30.3-0.00.20.0-0.9-1.41.1
Rest time, locomotor task time 20.40.51.00.90.90.50.3-0.90.51.00.40.0-0.3-0.90.9
Distance moved, locomotor task time 20.70.81.7-1.1-1.2-0.8-0.61.0-0.7-0.9-0.6-0.20.81.3-0.7
Vertical activity count, locomotor time 20.10.10.4-0.0-0.00.10.20.4-0.0-0.70.00.1-0.60.1-0.0
Light reinforcement 10.10.10.5-0.1-0.1-0.1-0.1-0.1-0.2-0.1-0.3-0.50.3-0.6-0.7
Light reinforcement 20.71.02.1-0.9-0.9-0.9-0.90.4-1.1-0.5-1.2-1.41.4-1.1-0.6
Bone: marrow area1.63.44.42.12.02.12.1-2.02.01.92.02.1-1.9-0.4-0.6
Bone: maximum diameter0.40.75.0-0.0-0.0-0.0-0.0-0.30.20.50.30.60.51.3-2.2
Bone: maximum force0.20.42.80.10.10.10.1-0.50.30.80.30.40.50.4-1.7
Bone: maximum moment0.30.52.10.40.40.40.4-0.80.61.00.60.60.10.2-1.4
Mean time between licks in bursts1.21.72.51.31.31.31.3-1.51.61.51.61.4-1.3-0.2-0.2
Mean num. licks in bursts1.21.53.6-1.4-1.4-1.4-1.40.8-1.2-0.5-1.3-1.31.90.30.0
Cd content in liver1.01.12.60.60.60.60.6-1.11.11.51.11.2-0.01.2-1.6
Co content in liver1.11.32.01.31.21.31.3-1.00.90.70.90.8-1.4-1.31.0
Cu content in liver0.50.61.2-0.8-0.7-0.8-0.70.6-0.9-0.6-0.9-1.10.8-0.90.5
Fe content in liver0.91.03.2-0.9-0.9-0.8-0.91.0-1.0-1.0-0.9-0.81.10.8-1.8
K content in liver2.52.44.7-1.1-1.0-1.1-1.11.2-1.8-1.5-1.9-2.11.0-2.22.0
Mg content in liver0.80.94.1-0.3-0.3-0.3-0.30.3-1.0-0.4-1.1-1.20.6-2.01.2
Mn content in liver1.71.93.3-1.4-1.5-1.4-1.41.8-1.6-1.8-1.5-1.31.00.60.2
Na content in liver3.13.36.2-1.4-1.3-1.4-1.41.5-2.1-1.8-2.3-2.51.4-2.21.9
Rb content in liver1.11.32.01.21.31.21.2-1.01.31.01.31.4-1.40.2-0.8
Se content in liver1.21.53.0-1.0-0.9-1.0-1.01.1-1.4-1.3-1.6-1.71.1-1.20.9
Sr content in liver0.70.74.4-0.1-0.1-0.1-0.1-0.20.30.40.30.60.41.6-2.1
Zn content in liver1.11.22.3-0.9-0.9-0.9-0.91.1-1.2-1.2-1.2-1.40.6-1.01.5
Bone: minimum diameter3.87.19.43.13.13.03.0-3.02.82.92.82.8-2.6-1.2-0.1
Time in familiar zone, hab. session 12.72.64.2-1.7-1.6-1.7-1.71.6-1.9-1.6-1.9-2.01.6-0.50.6
Time in novel zone, hab. session 17.17.09.42.82.82.82.9-2.83.02.83.13.1-2.7-0.2-0.2
Total zone transitions, hab. session 11.11.65.8-0.4-0.4-0.4-0.41.1-1.2-1.6-1.2-1.4-0.2-1.92.4
Total locomotion distance, hab. session 11.31.95.2-0.8-0.7-0.8-0.90.8-1.3-1.2-1.5-1.90.6-2.32.3
Locomotion velocity, hab. session 12.12.95.6-1.4-1.3-1.4-1.41.4-1.9-1.7-2.0-2.41.1-1.92.1
Time in familiar zone, hab. session 20.20.20.9-0.4-0.4-0.4-0.4-0.2-0.20.5-0.3-0.51.0-0.30.3
Time in novel zone, hab. session 20.80.82.31.00.90.91.0-0.40.90.10.91.1-1.50.4-0.4
Total zone transitions, hab. session 20.10.10.4-0.3-0.3-0.3-0.30.5-0.3-0.6-0.3-0.4-0.1-0.20.6
Total locomotion distance, hab. session 20.10.20.7-0.3-0.3-0.3-0.30.2-0.3-0.3-0.4-0.60.1-0.70.8
Locomotion velocity, hab. session 20.50.61.5-0.6-0.5-0.6-0.60.6-0.7-0.8-0.8-1.10.3-1.11.2
Novel to familiar place preference ratio0.10.10.40.20.20.20.2-0.1-0.1-0.1-0.2-0.1-0.0-0.7-0.4
Novelty place preference0.10.10.60.40.30.40.4-0.40.10.20.00.0-0.2-0.8-0.4
Time in novel zone, NPP test0.20.21.00.60.50.60.6-0.50.20.20.10.1-0.4-1.0-0.2
Total zone transitions, NPP test0.91.32.6-1.2-1.1-1.1-1.21.5-1.2-1.6-1.2-1.00.80.7-0.1
Total locomotion distance, NPP test1.01.42.2-1.2-1.1-1.2-1.21.2-1.4-1.3-1.4-1.51.2-0.50.3
Locomotion velocity, NPP test1.41.92.6-1.5-1.4-1.5-1.51.5-1.6-1.6-1.6-1.61.4-0.1-0.0
Intraocular pressure1.62.33.71.41.41.51.5-1.81.91.71.81.7-1.40.4-0.7
Delta distance traveled before/after self-admin0.40.43.30.40.40.40.40.20.0-0.30.10.3-0.9-0.51.8
Delta ambulatory time before/after self-admin0.30.43.20.20.20.20.20.5-0.2-0.5-0.10.2-0.7-0.11.8
Parametrial fat weight0.30.72.20.80.80.70.7-0.80.80.80.80.8-0.40.4-1.5
Pavlov. Cond. lever latency0.20.31.30.30.40.30.3-0.40.40.60.50.70.10.7-1.1
Pavlov. Cond. magazine entry latency0.30.41.3-0.5-0.6-0.5-0.50.5-0.5-0.6-0.6-0.90.1-0.71.2
Pavlov. Cond. change in total contacts0.20.20.6-0.2-0.2-0.2-0.20.4-0.4-0.6-0.4-0.4-0.1-0.50.8
Pavlov. Cond. index score0.91.22.4-0.9-1.0-0.9-0.91.1-1.1-1.3-1.2-1.40.4-0.81.5
Pavlov. Cond. latency score0.70.91.5-0.9-0.9-0.9-0.91.0-1.0-1.1-1.1-1.20.5-0.51.2
Pavlov. Cond. lever contacts0.50.61.4-0.6-0.7-0.6-0.60.9-0.8-1.1-0.8-0.90.1-0.51.2
Pavlov. Cond. magazine entry number0.60.71.30.70.80.70.7-0.90.81.10.91.1-0.20.6-1.1
Pavlov. Cond. intertrial magazine entries0.40.41.1-0.3-0.3-0.4-0.30.7-0.7-0.9-0.7-0.8-0.0-1.01.0
Pavlov. Cond. lever-magazine prob. diff.1.11.32.3-1.0-1.1-1.0-1.01.2-1.2-1.4-1.3-1.50.5-0.71.5
Pavlov. Cond. response bias0.40.52.4-0.3-0.3-0.3-0.30.6-0.6-0.8-0.6-0.8-0.2-1.01.5
Pavlov. Cond. lever latency0.10.10.4-0.1-0.0-0.1-0.10.6-0.4-0.7-0.4-0.1-0.0-0.10.4
Pavlov. Cond. magazine entry latency0.91.11.90.90.90.90.9-1.31.31.41.31.2-0.60.5-1.0
Pavlov. Cond. change in total contacts0.10.20.5-0.5-0.6-0.6-0.6-0.0-0.20.2-0.3-0.60.7-0.1-0.0
Pavlov. Cond. index score0.60.82.10.60.60.60.6-1.21.21.41.10.9-0.30.6-1.0
Pavlov. Cond. latency score0.40.51.30.20.20.20.2-0.80.81.10.80.60.10.9-1.1
Pavlov. Cond. lever contacts0.20.31.00.40.30.30.3-0.90.61.00.50.2-0.1-0.3-0.2
Pavlov. Cond. magazine entry number0.50.61.2-0.6-0.6-0.6-0.60.9-1.0-1.1-1.0-0.90.4-0.60.9
Pavlov. Cond. intertrial magazine entries0.00.00.10.10.10.20.20.1-0.1-0.3-0.0-0.0-0.2-0.20.2
Pavlov. Cond. lever-magazine prob. diff.0.60.82.00.60.50.60.6-1.21.21.41.10.8-0.30.5-1.0
Pavlov. Cond. response bias0.50.71.50.80.70.80.8-1.21.01.20.90.6-0.6-0.4-0.1
Time in closed arm before self-admin0.20.31.0-0.5-0.5-0.4-0.40.40.0-0.40.0-0.10.31.0-0.8
Time in closed arm after self-admin1.61.62.3-1.4-1.4-1.4-1.31.5-1.3-1.5-1.3-1.11.20.9-0.6
Time in open arm before self-admin0.10.20.60.50.50.50.5-0.1-0.10.20.10.7-0.00.5-0.3
Time in open arm after self-admin1.61.82.41.51.41.31.3-1.51.21.51.10.7-1.2-1.51.3
Bone: periosteal estimation0.30.72.40.70.70.70.7-0.80.70.80.81.0-0.40.5-1.5
Bone: periosteal perimeter0.10.21.9-0.2-0.2-0.3-0.30.0-0.20.1-0.2-0.10.70.5-1.4
Bone: post-yield work1.62.14.91.51.51.41.4-2.11.62.21.51.3-0.8-0.8-0.4
Progressive ratio test 1 active lever presses5.05.27.52.72.72.72.6-2.62.12.42.01.7-2.2-2.30.2
Progressive ratio test 1 breakpoint4.14.36.32.52.52.42.3-2.41.92.11.81.5-2.0-2.10.1
Progressive ratio test 1 inactive lever presses0.50.51.2-0.6-0.7-0.7-0.70.3-0.7-0.4-0.8-1.11.0-0.8-0.2
Progressive ratio test 2 active lever presses3.33.55.12.22.32.22.1-2.11.71.81.71.4-1.8-1.90.9
Progressive ratio test 2 breakpoint1.51.72.71.51.61.51.4-1.51.11.31.00.8-1.1-1.70.6
Progressive ratio test 2 inactive lever presses0.60.71.21.01.00.90.8-1.00.80.90.80.4-0.6-1.10.3
Incentive Sensitization - Responses2.22.23.01.71.71.71.6-1.61.71.51.71.6-1.5-0.20.3
Incentive Sensitization - Breakpoint2.42.53.31.81.81.71.7-1.71.81.61.81.7-1.6-0.30.4
Sum of active levers in priming session hrs 5-60.10.10.50.10.0-0.0-0.1-0.0-0.30.1-0.3-0.30.4-0.70.0
Progressive ratio0.30.30.5-0.7-0.7-0.6-0.60.6-0.6-0.5-0.5-0.30.60.6-0.3
Food seeking constrained by brief footshock0.10.10.4-0.2-0.3-0.3-0.30.4-0.3-0.5-0.3-0.10.20.6-0.5
Seeking ratio, punishment vs. effort0.00.10.10.30.30.30.2-0.30.20.20.10.1-0.1-0.20.3
Retroperitoneal fat weight0.41.42.91.31.31.31.3-1.21.40.91.30.9-1.7-0.90.0
Reaction time number correct0.91.31.81.21.31.21.1-1.11.31.01.31.3-1.20.3-0.9
Reaction time mean minus median0.91.32.01.11.21.01.0-1.41.31.41.21.2-0.50.5-1.2
Reaction time mean minus median AUC0.91.22.50.91.00.80.7-1.41.41.61.31.2-0.40.7-1.2
Reaction time num false alarms0.81.05.4-0.3-0.4-0.4-0.40.7-0.9-1.0-1.0-1.2-0.1-1.42.3
Reaction time num false alarms AUC0.81.16.0-0.3-0.3-0.4-0.40.8-0.8-1.0-0.9-1.2-0.2-1.42.5
Reaction time trials correct on left0.91.31.81.21.31.21.1-1.11.31.01.31.3-1.20.3-0.9
Reaction time trials on left0.91.31.91.21.31.21.2-1.11.31.01.31.4-1.20.4-1.0
Reaction time mean0.91.22.21.01.01.01.0-1.21.31.31.41.5-0.80.9-0.7
Reaction time mean AUC0.81.11.91.01.11.01.0-1.11.31.21.31.4-0.90.5-0.4
Median of all reaction times0.81.02.00.91.01.01.0-1.01.21.11.31.4-0.90.7-0.3
Reaction time omissions0.30.52.80.10.10.10.1-0.10.40.20.50.8-0.21.7-1.2
Reaction time false alarm rate1.21.77.4-0.7-0.8-0.7-0.81.0-1.2-1.3-1.3-1.60.2-1.52.7
Reaction time premature initiation rate0.40.61.2-0.5-0.5-0.6-0.70.6-0.8-0.7-0.9-1.10.7-0.81.0
Reaction time premature initiations0.00.10.40.10.10.0-0.10.1-0.2-0.1-0.2-0.40.1-0.60.3
Std. dev. reaction times0.60.81.30.91.00.90.9-1.01.01.01.11.1-0.60.6-0.6
Reaction time trials completed0.91.31.91.21.31.21.2-1.11.31.01.31.4-1.20.4-1.0
Reaction time trials AUC1.21.82.61.41.51.41.3-1.21.51.21.51.6-1.40.4-1.1
Run reversals in cocaine runway, females0.50.50.9-0.6-0.6-0.5-0.50.9-1.0-0.9-0.9-0.50.90.0-0.3
Run reversals in cocaine runway, males0.70.74.5-0.1-0.1-0.1-0.1-0.20.50.50.50.70.41.6-2.1
Latency to leave start box in cocaine runway1.11.21.91.31.31.21.2-1.11.20.81.10.8-1.4-0.6-0.8
Latency to leave start box in cocaine runway, F0.80.91.31.11.11.11.1-1.00.90.60.80.4-1.2-1.2-0.3
Latency to leave start box in cocaine runway, M1.71.62.51.11.11.11.1-1.11.51.21.61.5-1.11.3-1.6
Std. dev. time between licks in bursts0.20.20.40.40.40.40.4-0.60.50.50.50.2-0.5-0.60.2
Total sessions with >9 infusions0.70.81.11.11.01.00.9-0.90.71.00.80.9-0.3-0.0-1.1
Short access day 1 total inactive lever presses0.00.00.1-0.00.00.00.0-0.00.1-0.10.0-0.2-0.1-0.30.2
Short access day 10 total inactive lever presses3.43.85.2-2.2-2.2-2.2-2.32.1-2.0-2.0-1.9-2.12.10.9-0.4
Short access day 1 total infusions0.30.31.40.60.60.60.5-0.60.20.60.20.0-0.2-1.20.1
Short access day 10 total infusions0.60.72.51.00.90.90.8-0.90.50.80.50.3-0.5-1.6-0.2
Short access total infusions0.60.71.01.00.90.90.9-1.00.71.00.70.8-0.5-0.5-0.6
Short access day 1 locomotion2.12.23.21.81.71.71.7-1.51.31.21.20.9-1.7-1.81.1
Short access day 10 total locomotion0.20.20.50.70.60.60.6-0.40.30.20.30.1-0.6-0.70.2
Short access total locomotion0.60.61.11.01.01.01.0-0.70.60.70.60.7-0.7-0.60.1
One hour access (0.3 mA shock)4.55.26.92.62.62.62.6-2.42.32.02.21.8-2.6-2.10.9
Compulsive drug intake3.83.85.6-2.4-2.4-2.3-2.32.1-2.0-2.0-1.9-1.72.01.2-0.0
One hour access (shock baseline)6.87.911.63.43.43.33.3-3.02.72.72.62.3-2.8-2.30.9
Social response proportion0.20.30.60.50.40.50.5-0.70.60.80.60.6-0.3-0.10.3
Social responses0.30.41.00.80.70.70.6-0.20.3-0.20.30.1-1.0-1.00.5
Social time0.20.30.50.40.50.60.6-0.60.70.60.70.7-0.60.0-0.2
Soleus weight4.814.119.5-4.1-4.0-4.1-4.14.4-4.2-4.3-4.2-4.03.41.01.1
Bone: stiffness0.20.32.20.30.30.30.3-0.4-0.20.1-0.3-0.4-0.1-1.50.2
Tibialis anterior weight3.311.315.2-3.9-3.9-3.9-3.93.6-3.4-3.3-3.4-3.33.52.0-0.5
Time to tail flick, vehicle, before self-admin2.02.13.11.61.51.51.5-1.61.71.51.71.4-1.8-0.10.4
Time to tail flick, vehicle, after self-admin0.50.51.9-0.2-0.3-0.2-0.20.9-0.8-1.2-0.8-0.6-0.3-0.51.4
Time to tail flick, test, before self-admin0.30.30.4-0.6-0.6-0.6-0.60.6-0.5-0.6-0.4-0.50.5-0.10.5
Time to tail flick, test, after self-admin2.52.64.11.81.82.02.0-1.51.61.21.61.8-2.0-0.90.3
Delta time to tail flick, vehicle, before/after SA1.51.53.0-1.2-1.2-1.1-1.11.5-1.6-1.7-1.5-1.21.0-0.30.4
Delta time to tail flick, test, before/after SA1.41.32.01.41.31.41.4-1.10.90.90.91.2-1.3-0.90.3
Tibia length1.33.76.92.02.02.12.0-1.92.12.02.32.6-1.70.8-0.8
Ambulatory time before self-admin1.81.83.01.61.51.61.5-1.41.21.01.10.7-1.7-1.50.9
Ambulatory time after self-admin3.74.08.62.22.12.22.3-1.41.50.91.51.3-2.9-2.02.8
Bone: tissue strength0.20.21.10.40.40.40.4-0.50.30.40.2-0.0-0.3-1.10.6
Total heroin consumption2.73.15.92.12.12.12.1-1.51.71.11.71.7-2.4-0.71.0
Bone: trabecular number1.52.43.2-1.7-1.6-1.7-1.71.6-1.7-1.6-1.7-1.61.80.4-0.9
Bone: trabecular spacing0.10.10.8-0.1-0.3-0.2-0.20.1-0.2-0.1-0.2-0.40.1-0.30.9
Bone: trabecular thickness0.60.81.3-0.9-0.8-0.9-0.90.9-0.8-0.9-0.8-0.70.90.6-1.1
Bone: trabecular tissue density0.10.10.4-0.1-0.1-0.2-0.10.3-0.2-0.4-0.2-0.20.1-0.2-0.6
Water consumed over 24 hours0.10.10.30.30.20.30.2-0.60.40.60.20.1-0.0-0.10.1
Number of responses in last shaping day1.11.12.7-0.9-0.9-0.9-1.00.7-0.9-0.8-1.0-1.60.6-1.51.2