Hub : Genes

Aif1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Aif1 0.11 0.06 4.2e-05 0.1 0.08 0.08 0.09 3.6e-06 7.8e-05 5.9e-05 2.1e-05
2 pVTA gene expression Aif1 0.22 0.1 3.5e-14 0.11 0.16 0.15 0.12 2.2e-09 1.8e-12 3.4e-12 1.4e-09
3 LHb gene expression Aif1 0.11 0.07 9.0e-03 0.05 0.11 0.06 0.07 2.1e-02 1.5e-03 1.3e-02 7.7e-03
4 Liver gene expression Aif1 0.15 0.06 0.0e+00 0.16 0.15 0.18 0.18 1.3e-17 1.1e-16 9.4e-20 8.2e-20
5 Adipose gene expression Aif1 0.21 0.08 0.0e+00 0.24 0.26 0.26 0.26 2.8e-26 4.7e-29 1.1e-28 3.9e-29
6 Brain gene expression Aif1 0.16 0.07 5.0e-13 0.07 0.12 0.1 0.11 5.8e-07 1.8e-11 6.3e-10 1.6e-10
7 IL gene expression Aif1 0.37 0.14 2.3e-05 0.03 0.13 0.1 0.09 5.5e-02 5.5e-04 2.5e-03 4.4e-03
8 Liver mRNA stability Aif1 0.07 0.04 2.8e-07 0.06 0.03 0.05 0.03 1.2e-07 1.1e-04 3.0e-06 1.1e-04
9 PL gene expression Aif1 0.14 0.06 0.0e+00 0.2 0.19 0.19 0.2 3.8e-21 8.0e-21 8.6e-21 2.8e-21
10 NAcc gene expression Aif1 0.1 0.05 1.3e-15 0.1 0.1 0.1 0.11 7.0e-15 2.4e-14 2.4e-15 8.7e-16
11 pVTA intron excision ratio chr20_3655783_3655890 0.06 0.04 4.8e-03 0.02 0.02 0.01 0.01 1.2e-02 1.2e-02 5.1e-02 3.7e-02
12 Liver intron excision ratio chr20_3655783_3655890 0.06 0.04 9.8e-03 -0 -0 -0 0 4.4e-01 8.9e-01 6.6e-01 3.7e-01
13 Adipose intron excision ratio chr20_3655564_3655722 0.2 0.1 1.8e-03 -0 -0 0 0 4.1e-01 9.1e-01 9.9e-02 1.6e-01
14 Adipose intron excision ratio chr20_3655783_3655890 0.18 0.1 7.7e-03 -0 -0 0 0 5.7e-01 7.3e-01 3.2e-01 3.7e-01
15 IC gene expression Aif1 0.14 0.07 3.8e-05 0.12 0.08 0.08 0.11 6.7e-06 3.6e-04 2.6e-04 3.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density1.12.03.61.91.21.81.71.51.61.11.81.71.3-0.4-1.90.60.00.0
Area under the delay curve0.20.31.4-1.2-0.4-0.5-0.5-0.6-0.8-0.5-0.5-0.3-0.3-0.40.3-0.00.00.0
BMI with tail0.62.26.5-2.3-2.6-1.4-1.4-1.4-0.7-0.9-1.9-1.8-2.3-0.31.4-0.70.00.0
BMI without tail2.57.512.3-3.0-3.5-3.3-3.2-3.2-3.1-3.0-3.1-3.2-3.3-1.61.4-2.20.00.0
Body weight2.310.328.2-5.3-3.8-3.7-3.6-3.4-2.4-2.0-4.1-4.1-4.00.23.6-0.80.00.0
Weight adjusted by age2.33.47.4-1.8-2.4-2.3-2.0-2.0-1.5-1.1-2.5-2.7-2.20.52.70.40.00.0
Bone surface0.00.10.4-0.30.30.20.00.20.40.50.00.00.00.60.40.20.00.0
Bone volume0.00.00.20.10.10.30.20.10.40.20.30.2-0.0-0.1-0.30.10.00.0
Breakpoint value in progressive ratio session0.20.20.60.60.80.40.50.40.20.20.70.50.7-0.2-0.7-0.10.00.0
Number of licking bursts0.30.51.5-0.11.20.80.60.60.81.10.40.70.91.20.40.60.00.0
Context. condit. distance diff. score5.06.010.52.72.82.82.73.03.23.22.02.22.52.80.22.80.00.0
Locomotion velocity, session 10.10.20.50.50.70.40.60.20.20.30.50.60.60.1-0.20.20.00.0
Locomotion distance, session 11.01.22.80.60.81.51.61.41.10.91.71.41.40.1-1.30.40.00.0
Locomotion velocity, session 20.30.40.90.00.90.80.90.60.50.70.80.90.80.3-0.20.20.00.0
Locomotion distance, session 21.72.34.80.71.22.02.21.91.91.91.81.61.71.1-0.61.60.00.0
Locomotion velocity, session 30.40.51.8-0.0-0.6-0.6-0.6-0.8-1.0-1.1-0.2-0.4-0.5-1.4-0.6-1.10.00.0
Locomotion distance, session 31.61.73.11.51.41.61.71.61.21.01.81.61.7-0.1-1.50.60.00.0
Stereotopy head waving bouts, day 30.81.03.0-1.7-0.4-1.0-1.2-1.3-0.8-0.4-1.4-1.1-0.80.41.6-0.30.00.0
Stereotopy head waving duration, day 31.72.04.4-1.6-1.1-1.8-1.9-2.1-1.7-1.3-1.9-1.6-1.4-0.51.4-1.10.00.0
Locomotion velocity, session 75.96.411.82.52.43.23.43.13.12.83.02.92.81.1-1.52.50.00.0
Locomotion distance, session 75.36.812.62.52.63.33.53.12.72.43.53.33.40.4-2.21.90.00.0
Stereotopy head waving bouts, day 71.31.44.0-2.0-0.4-1.2-1.4-1.2-1.8-1.5-0.9-0.5-0.7-1.2-0.1-1.90.00.0
Stereotopy head waving duration, day 71.21.54.0-2.0-0.7-1.3-1.5-1.4-1.7-1.4-1.2-0.8-1.0-1.10.2-1.80.00.0
Locomotion velocity, session 81.31.55.2-0.21.71.01.01.01.31.80.40.71.32.31.31.60.00.0
Locomotion distance, session 86.59.417.12.43.13.73.83.84.14.12.82.83.23.30.03.60.00.0
Degree of sensitization distance0.40.51.40.20.70.60.60.50.81.00.50.40.61.20.81.00.00.0
Degree of sensitization stereotypy0.50.62.8-1.20.1-0.4-0.5-0.3-1.2-1.0-0.10.2-0.1-1.0-0.8-1.70.00.0
Conditioned locomotion0.40.52.2-0.9-0.5-0.4-0.5-0.50.20.4-0.8-0.8-0.61.01.50.80.00.0
Cocaine response after cond. corrected1.62.04.70.71.01.71.51.62.22.11.01.11.21.60.22.10.00.0
Cocaine response after cond. not corrected0.40.41.9-0.40.40.30.20.20.81.0-0.2-0.10.21.41.11.10.00.0
Cocaine response before conditioning4.45.39.7-2.5-1.7-3.0-3.0-3.1-3.0-2.5-2.6-2.6-2.4-0.81.6-2.30.00.0
Saline control response4.56.011.4-1.2-2.6-2.9-2.9-3.0-3.2-3.4-2.1-2.4-2.6-3.0-0.2-2.80.00.0
Bone: connectivity density1.32.05.22.31.31.81.61.62.01.61.41.51.10.5-1.01.10.00.0
Bone: cortical apparent density0.40.61.5-0.1-1.2-0.7-0.7-1.1-0.6-0.9-0.5-0.7-0.9-1.2-0.4-0.60.00.0
Bone: cortical area0.20.32.7-1.6-0.3-0.4-0.3-0.3-0.4-0.1-0.3-0.5-0.20.30.5-0.50.00.0
Bone: cortical porosity1.41.65.6-0.9-0.6-1.4-1.2-1.3-2.4-2.1-0.7-0.6-0.6-1.7-0.4-1.80.00.0
Bone: cortical porosity1.01.03.9-1.1-0.3-1.2-1.0-1.1-2.0-1.6-0.7-0.5-0.4-1.00.1-1.40.00.0
Bone: cortical thickness0.50.82.8-1.7-1.1-0.5-0.5-0.6-0.9-1.0-0.1-0.4-0.5-1.4-0.9-1.50.00.0
Bone: cortical thickness0.70.82.3-0.8-1.2-0.7-0.6-0.5-1.0-1.2-0.1-0.6-0.7-1.4-0.9-1.50.00.0
Bone: cortical tissue density0.40.61.5-0.0-1.2-0.7-0.8-1.1-0.6-0.9-0.6-0.7-0.9-1.1-0.3-0.60.00.0
Condit. Reinf. active minus inactive responses0.40.51.61.30.70.30.60.9-0.2-0.30.90.70.8-0.4-1.0-0.50.00.0
Condit. Reinf. active-inactive response ratio0.50.52.1-0.1-0.4-0.7-0.6-0.2-1.2-1.2-0.2-0.4-0.4-0.9-0.6-1.40.00.0
Condit. Reinf. active responses0.80.93.51.90.90.91.21.20.50.31.31.01.0-0.4-1.20.20.00.0
Condit. Reinf. inactive responses1.92.45.42.31.31.92.01.51.61.12.11.81.6-0.6-1.91.00.00.0
Incentive salience index mean2.02.44.71.61.91.82.02.21.51.61.81.61.91.2-0.61.30.00.0
Condit. Reinf. lever presses4.86.812.41.92.83.03.23.03.43.52.52.32.82.7-0.03.30.00.0
Condit. Reinf. active minus inactive responses1.21.53.1-1.0-1.1-1.7-1.6-1.8-1.6-1.4-1.4-1.5-1.3-0.60.9-1.00.00.0
Condit. Reinf. active-inactive response ratio1.51.73.1-1.6-1.1-1.7-1.7-1.7-1.5-1.1-1.8-1.6-1.30.11.5-0.60.00.0
Condit. Reinf. active responses0.40.61.20.5-0.5-1.0-1.0-1.1-1.0-1.0-0.7-0.9-0.7-0.70.2-0.90.00.0
Condit. Reinf. inactive responses0.30.33.01.70.2-0.1-0.00.0-0.1-0.50.3-0.0-0.0-0.7-0.7-0.70.00.0
Condit. Reinf. lever presses0.20.21.21.10.2-0.2-0.2-0.2-0.5-0.6-0.10.0-0.2-0.7-0.4-0.70.00.0
Condit. Reinf. lever reinforcers received0.40.51.00.6-0.2-0.9-0.9-1.0-1.0-1.0-0.5-0.7-0.5-0.70.1-1.00.00.0
Conditioned reinforcement - actives0.10.21.0-1.0-0.7-0.30.1-0.0-0.4-0.40.0-0.2-0.1-0.3-0.40.00.00.0
Conditioned reinforcement - inactives0.30.41.4-0.9-1.2-0.7-0.3-0.5-0.9-0.9-0.4-0.6-0.6-0.9-0.2-0.20.00.0
Conditioned locomotion0.10.10.7-0.2-0.4-0.10.10.3-0.00.0-0.2-0.3-0.20.00.10.80.00.0
Patch foraging indifference point 0 sec1.73.26.0-0.8-2.3-2.1-2.0-2.4-2.2-2.4-1.6-1.8-2.1-2.30.0-1.40.00.0
Patch foraging indifference point AUC0.30.41.1-1.0-0.1-0.6-0.7-0.9-1.1-0.8-0.4-0.3-0.3-0.7-0.1-1.00.00.0
Delay disc. indifference point, 0s delay0.30.31.2-0.60.30.40.50.40.60.80.20.30.50.80.81.10.00.0
Delay disc. indifference point, 16s delay0.40.51.2-1.0-0.9-0.5-0.5-0.7-1.0-0.9-0.4-0.2-0.6-1.1-0.4-0.60.00.0
Delay disc. indifference point, 2s delay0.70.83.3-1.8-0.7-1.0-0.8-1.1-1.2-0.7-1.0-0.9-0.60.11.00.20.00.0
Delay disc. indifference point, 24s delay1.01.22.6-0.9-1.2-1.2-1.3-1.4-1.6-1.4-1.3-0.9-1.2-1.00.6-0.50.00.0
Delay disc. indifference point, 4s delay1.11.22.2-1.3-0.7-1.4-1.4-1.5-1.5-1.2-1.3-1.2-1.1-0.70.7-0.70.00.0
Delay disc. indifference point, 8s delay0.10.10.2-0.40.10.10.20.2-0.2-0.00.30.30.4-0.1-0.30.30.00.0
Indifference point function ln k0.10.20.60.00.80.50.60.50.30.60.60.60.80.7-0.20.30.00.0
Indifference point function log k0.10.20.60.00.80.50.60.50.30.60.60.60.80.7-0.20.30.00.0
Patch foraging total patch changes 0 sec1.83.56.5-1.0-2.4-2.2-2.1-2.5-2.4-2.6-1.6-1.8-2.1-2.4-0.1-1.50.00.0
Patch foraging total patch changes 12 sec1.92.54.6-1.0-1.7-1.7-1.8-2.1-2.0-2.1-1.5-1.4-1.7-2.10.1-1.70.00.0
Patch foraging total patch changes 18 sec0.60.94.20.1-1.3-0.7-0.7-0.8-0.9-1.4-0.1-0.5-0.9-2.1-1.0-1.10.00.0
Patch foraging total patch changes 24 sec0.30.63.40.7-0.70.10.0-0.1-0.4-0.80.30.3-0.3-1.9-1.7-0.60.00.0
Patch foraging total patch changes 6 sec1.72.64.9-1.0-2.2-1.7-1.7-1.9-1.9-2.2-1.6-1.4-1.9-2.2-0.1-1.40.00.0
Patch foraging time to switch 0 sec0.20.31.10.6-0.70.40.40.41.10.7-0.1-0.2-0.30.50.70.90.00.0
Patch foraging water rate 0 sec0.20.42.3-1.5-0.8-0.6-0.6-0.7-0.7-0.5-0.6-0.6-0.6-0.10.30.10.00.0
Patch foraging water rate 12 sec0.20.31.70.50.20.30.40.6-0.0-0.20.80.60.5-0.6-1.3-0.60.00.0
Patch foraging water rate 18 sec0.10.20.6-0.1-0.4-0.6-0.7-0.4-0.6-0.6-0.8-0.5-0.7-0.4-0.1-0.30.00.0
Patch foraging water rate 24 sec0.20.32.0-1.4-0.4-0.4-0.5-0.3-0.6-0.6-0.1-0.1-0.2-0.5-0.7-0.70.00.0
Patch foraging water rate 6 sec0.10.11.0-0.3-0.20.00.20.1-0.2-0.30.40.20.2-0.4-1.0-0.30.00.0
Seeking ratio, delayed vs. immediate footshock1.21.55.4-0.2-0.2-1.4-1.6-1.6-1.8-1.7-0.6-0.8-0.7-1.4-0.6-2.30.00.0
Distance traveled before self-admin0.30.31.10.20.40.30.10.41.01.1-0.3-0.2-0.20.71.00.80.00.0
Distance traveled after self-admin1.11.42.8-1.1-0.8-1.4-1.7-1.5-1.1-0.9-1.6-1.5-1.5-0.51.3-1.20.00.0
Extensor digitorum longus weight0.10.41.8-0.2-0.0-0.1-0.2-0.30.50.6-0.7-0.4-0.41.11.31.10.00.0
Bone: elastic displacement0.40.52.8-0.5-0.6-0.4-0.3-0.8-1.0-1.1-0.1-0.0-0.3-1.7-0.9-0.60.00.0
Bone: elastic work0.50.63.7-1.9-0.9-0.7-0.6-1.0-0.9-0.7-0.6-0.5-0.7-0.80.1-0.30.00.0
Bone: endosteal estimation1.94.114.8-2.3-1.0-2.4-2.4-2.0-1.3-0.6-2.8-2.7-2.02.03.80.20.00.0
Bone: endosteal perimeter0.61.36.9-0.50.7-0.3-0.30.10.61.1-0.9-0.8-0.22.62.61.20.00.0
Epididymis fat weight1.34.618.0-1.4-4.2-1.7-1.6-1.9-1.8-2.8-1.1-1.8-2.6-3.2-1.6-2.00.00.0
Delta time in closed arm before/after self-admin0.60.51.4-1.1-1.0-0.5-0.6-0.8-0.1-0.0-1.0-0.9-0.80.71.20.50.00.0
Delta time in open arm before/after self-admin0.20.21.40.1-0.3-0.5-0.2-0.0-0.7-0.8-0.1-0.3-0.4-1.2-0.4-0.60.00.0
Diff in mean of infusions in LGA sessions3.74.58.12.32.22.62.72.82.52.32.72.42.60.8-1.21.40.00.0
Delay discount exponential model param0.40.41.61.20.50.70.70.81.10.80.70.50.50.6-0.30.20.00.0
Extinction: sum of active levers before priming0.40.41.10.40.60.70.70.30.80.90.40.50.70.70.51.00.00.0
Active lever presses in extinction session 60.10.10.60.2-0.6-0.10.2-0.1-0.3-0.4-0.0-0.0-0.3-0.8-0.50.40.00.0
Bone: final force1.32.110.3-3.2-2.0-1.3-1.5-1.3-1.0-0.9-1.7-1.6-1.8-0.20.9-0.60.00.0
Bone: final moment1.22.08.6-2.9-1.9-1.4-1.5-1.4-1.1-1.0-1.6-1.6-1.8-0.30.9-0.60.00.0
Food consumed during 24 hour testing period0.40.62.4-0.9-0.2-0.0-0.1-0.00.70.9-0.7-0.6-0.41.31.51.30.00.0
Glucose1.21.96.20.91.50.70.80.91.31.9-0.00.31.02.52.22.20.00.0
Heart weight2.74.17.2-2.7-2.4-2.6-2.3-2.3-2.5-2.1-2.4-2.4-2.1-0.71.8-1.10.00.0
Delay discount hyperbolic model param0.50.61.91.40.60.90.81.01.31.00.70.60.50.7-0.30.40.00.0
Intermittent access intake day 1-15 change0.10.21.40.40.4-0.1-0.2-0.2-0.3-0.40.30.20.1-0.4-0.4-1.20.00.0
Intermittent access intake escalation0.30.73.70.40.1-0.5-0.6-0.7-1.0-1.20.10.0-0.2-1.3-1.1-1.90.00.0
Intermittent access intake escalation 20.20.21.00.40.8-0.1-0.1-0.3-0.2-0.30.30.30.3-0.3-0.5-1.00.00.0
Intermitt. access day 1 inactive lever presses0.20.73.2-1.10.30.30.20.10.81.2-0.2-0.10.41.81.60.90.00.0
Intermitt. access day 15 inactive lever presses0.30.72.2-1.5-0.9-0.8-0.8-1.2-0.6-0.4-1.0-1.0-0.90.11.2-0.20.00.0
Intermitt. access escalation Index2.23.15.21.72.22.22.22.32.12.12.01.92.10.9-0.81.50.00.0
Intermittent access day 1 total infusions0.40.71.90.60.20.81.41.20.40.31.10.90.9-0.6-1.11.00.00.0
Intermittent access day 15 total infusions0.30.42.30.50.00.00.30.1-0.6-0.80.60.40.3-1.3-1.5-0.80.00.0
Intermittent access terminal intake (last 3 days)0.40.51.9-0.1-0.6-0.6-0.2-0.3-1.1-1.2-0.1-0.2-0.3-1.4-1.0-0.90.00.0
Intermittent access total infusions0.20.31.40.1-0.4-0.20.20.2-0.6-0.80.20.10.0-1.2-1.2-0.20.00.0
Intermittent access day 1 locomotion0.20.20.90.90.10.30.50.90.40.20.40.20.1-0.2-0.60.60.00.0
Intermittent access day 15 total locomotion0.10.20.5-0.6-0.4-0.7-0.7-0.1-0.4-0.5-0.6-0.7-0.7-0.40.4-0.50.00.0
Intermittent access total locomotion0.10.20.7-0.2-0.4-0.5-0.30.1-0.5-0.6-0.2-0.4-0.4-0.8-0.4-0.40.00.0
Intermittent access standard deviation1.12.44.4-1.4-2.1-2.0-1.8-1.7-1.9-1.9-1.6-1.8-1.8-1.00.5-1.50.00.0
Left kidney weight2.210.322.3-4.7-3.9-3.9-3.8-3.7-3.1-2.9-3.7-4.1-3.9-1.22.5-1.80.00.0
Right kidney weight1.98.420.1-4.5-3.5-3.4-3.4-3.4-2.4-2.2-3.5-3.8-3.7-0.62.7-1.20.00.0
Cocaine induced anxiety0.40.51.40.70.90.70.70.81.01.10.30.40.51.20.61.00.00.0
Post-drug Anxiety0.10.10.50.4-0.0-0.3-0.3-0.40.00.1-0.4-0.5-0.30.20.70.10.00.0
Baseline Anxiety0.30.40.9-0.0-1.0-0.6-0.7-0.9-0.7-0.7-0.5-0.6-0.5-0.8-0.0-0.60.00.0
Tail length2.07.814.2-3.7-2.0-3.8-3.7-3.5-3.2-2.4-3.6-3.5-2.8-0.13.0-1.20.00.0
Length with tail2.29.421.0-4.6-2.4-3.8-3.7-3.6-2.6-1.8-4.1-4.1-3.30.74.1-0.20.00.0
Length without tail1.96.018.8-4.3-2.4-2.2-2.2-2.1-0.50.1-3.2-3.2-2.72.24.11.40.00.0
Times rat made contact with spout1.11.37.80.80.30.30.2-0.1-0.7-1.10.80.90.3-2.8-2.2-1.70.00.0
Lifetime Intake0.20.20.9-0.1-0.5-0.30.20.2-0.7-0.70.1-0.1-0.1-0.9-1.0-0.00.00.0
Liver weight, left0.91.48.0-0.9-0.1-0.9-0.9-0.40.20.6-1.4-1.4-0.92.22.80.90.00.0
Liver weight, right1.01.710.6-2.0-0.2-0.9-0.8-0.9-0.10.5-1.5-1.3-0.91.83.31.00.00.0
Locomotor activity1.01.53.1-1.0-0.2-1.7-1.7-1.8-1.5-1.3-1.5-1.5-1.3-0.40.7-1.30.00.0
Locomotor testing distance0.30.51.2-0.5-0.3-1.0-0.9-1.0-0.6-0.5-0.8-1.1-0.70.30.8-0.20.00.0
Locomotor testing rearing0.40.71.8-0.8-0.7-1.1-1.1-1.2-0.4-0.3-1.2-1.2-1.10.51.30.20.00.0
Locomotion in novel chamber0.10.10.4-0.7-0.0-0.2-0.3-0.3-0.2-0.2-0.2-0.1-0.2-0.1-0.3-0.40.00.0
Locomotion in novel chamber post-restriction0.71.12.4-1.1-1.6-1.3-1.3-1.3-1.0-1.0-1.2-1.4-1.3-0.50.3-0.40.00.0
Fecal boli incidents, locomotor time 10.10.10.70.9-0.50.00.4-0.10.40.2-0.0-0.2-0.2-0.3-0.00.90.00.0
Change in fecal boli incidents, locomotor task0.60.63.4-1.8-0.1-0.2-0.40.00.00.5-0.4-0.40.11.51.60.30.00.0
Time >=10cm from walls, locomotor time 11.41.45.5-1.5-0.8-0.8-1.0-0.70.20.5-1.8-1.4-1.41.82.30.70.00.0
Bouts of movement, locomotor time 10.60.72.61.11.61.00.80.90.90.80.91.10.90.1-0.5-0.10.00.0
Total resting periods, locomotor time 10.50.52.00.81.40.90.60.70.90.80.70.90.70.2-0.30.10.00.0
Rest time, locomotor task time 10.10.10.4-0.30.0-0.5-0.4-0.7-0.3-0.2-0.7-0.5-0.50.10.5-0.10.00.0
Distance moved, locomotor task time 10.10.21.0-1.0-0.6-0.3-0.5-0.4-0.4-0.3-0.3-0.3-0.4-0.20.00.00.00.0
Vertical activity count, locomotor time 10.10.20.6-0.7-0.7-0.4-0.6-0.2-0.4-0.4-0.2-0.5-0.4-0.0-0.3-0.40.00.0
Time >=10cm from walls, locomotor time 20.71.12.9-0.9-1.1-1.0-1.0-0.8-0.30.1-1.5-1.5-1.01.41.70.90.00.0
Bouts of movement, locomotor time 20.20.41.8-0.40.5-0.6-0.7-0.8-0.9-0.8-0.4-0.2-0.3-0.40.2-1.30.00.0
Total resting periods, locomotor time 20.20.31.6-0.30.8-0.5-0.6-0.7-0.9-0.7-0.4-0.1-0.2-0.30.2-1.30.00.0
Rest time, locomotor task time 20.91.23.50.31.60.90.70.81.61.70.10.60.61.91.41.10.00.0
Distance moved, locomotor task time 20.50.62.8-1.2-1.7-0.7-0.6-0.7-0.6-0.6-0.6-0.8-0.9-0.5-0.20.60.00.0
Vertical activity count, locomotor time 20.30.41.9-0.4-1.4-0.7-0.6-0.5-0.5-0.6-0.6-0.9-0.7-0.10.10.50.00.0
Light reinforcement 10.10.20.7-0.3-0.30.40.10.20.80.7-0.1-0.0-0.30.60.20.60.00.0
Light reinforcement 20.30.41.6-0.6-0.00.30.10.31.01.0-0.4-0.3-0.41.30.91.20.00.0
Bone: marrow area2.04.515.3-2.3-1.2-2.6-2.5-2.1-1.4-0.7-2.9-2.8-2.22.03.90.10.00.0
Bone: maximum diameter0.40.73.8-1.01.00.30.40.60.71.2-0.00.00.51.91.40.70.00.0
Bone: maximum force0.91.68.7-2.9-1.7-1.1-1.3-1.0-0.8-0.6-1.6-1.4-1.60.21.1-0.20.00.0
Bone: maximum moment0.91.67.3-2.7-1.6-1.2-1.3-1.1-0.9-0.7-1.5-1.4-1.50.11.1-0.20.00.0
Mean time between licks in bursts0.40.92.40.71.50.80.90.71.01.30.80.71.21.50.61.00.00.0
Mean num. licks in bursts0.81.36.90.4-1.0-0.7-0.6-0.8-1.2-1.7-0.1-0.3-0.9-2.6-1.4-1.60.00.0
Cd content in liver0.30.42.10.5-0.40.60.70.41.00.70.30.10.00.2-0.11.50.00.0
Co content in liver0.80.93.4-1.0-1.9-1.0-0.8-1.1-0.7-0.8-0.9-1.3-1.2-0.40.8-0.20.00.0
Cu content in liver1.01.24.82.10.70.80.70.6-0.1-0.51.11.10.8-1.8-2.2-1.00.00.0
Fe content in liver0.40.51.5-0.6-1.2-0.8-0.7-0.9-0.7-0.9-0.6-0.7-1.0-0.8-0.5-0.30.00.0
K content in liver0.80.81.60.20.81.31.11.21.11.01.21.21.00.5-0.40.40.00.0
Mg content in liver1.91.94.10.71.71.71.61.61.82.01.41.41.51.80.41.00.00.0
Mn content in liver2.32.68.11.11.61.31.51.72.02.31.00.81.42.81.42.20.00.0
Na content in liver0.50.52.6-0.40.40.30.20.4-0.4-0.41.00.70.8-0.7-1.6-1.20.00.0
Rb content in liver0.70.81.81.10.51.00.91.11.31.20.60.60.71.10.71.30.00.0
Se content in liver0.50.53.20.21.80.70.60.50.50.90.30.80.80.90.60.30.00.0
Sr content in liver0.40.41.2-0.9-0.6-0.7-0.6-0.4-0.2-0.1-0.7-0.7-0.70.61.10.50.00.0
Zn content in liver0.20.20.70.00.10.20.40.10.50.60.20.00.30.80.80.60.00.0
Bone: minimum diameter0.51.05.1-1.10.3-0.3-0.2-0.10.50.9-0.7-0.9-0.22.22.31.10.00.0
Time in familiar zone, hab. session 11.51.56.22.10.50.70.70.5-0.1-0.71.21.20.8-2.2-2.5-1.10.00.0
Time in novel zone, hab. session 11.41.45.0-1.6-0.8-1.2-1.2-0.8-0.5-0.0-1.6-1.5-1.11.72.20.50.00.0
Total zone transitions, hab. session 10.50.71.71.10.91.01.01.30.90.81.10.91.10.7-0.40.20.00.0
Total locomotion distance, hab. session 10.71.02.30.80.81.21.31.51.11.11.31.01.30.9-0.40.70.00.0
Locomotion velocity, hab. session 10.40.51.40.40.50.80.91.20.70.71.10.71.00.7-0.30.20.00.0
Time in familiar zone, hab. session 20.30.32.40.60.2-0.1-0.20.1-0.4-0.70.30.2-0.0-1.0-0.8-1.60.00.0
Time in novel zone, hab. session 20.30.30.8-0.6-0.8-0.7-0.6-0.6-0.6-0.4-0.9-0.7-0.70.00.60.50.00.0
Total zone transitions, hab. session 20.40.61.20.00.61.00.90.81.11.11.00.70.90.8-0.20.50.00.0
Total locomotion distance, hab. session 21.82.44.61.01.32.01.92.12.12.01.81.61.81.4-0.61.20.00.0
Locomotion velocity, hab. session 22.33.15.51.01.62.32.22.32.32.22.11.92.11.6-0.71.50.00.0
Novel to familiar place preference ratio0.10.10.2-0.10.10.20.20.1-0.2-0.10.40.40.3-0.3-0.30.10.00.0
Novelty place preference0.10.10.2-0.4-0.0-0.1-0.1-0.2-0.5-0.30.20.20.2-0.4-0.2-0.10.00.0
Time in novel zone, NPP test0.10.10.5-0.5-0.2-0.3-0.3-0.3-0.7-0.6-0.10.0-0.0-0.4-0.1-0.30.00.0
Total zone transitions, NPP test1.62.44.01.51.41.92.02.02.01.81.71.61.81.3-0.61.40.00.0
Total locomotion distance, NPP test2.12.95.51.10.92.12.32.32.32.12.01.61.81.6-0.52.10.00.0
Locomotion velocity, NPP test3.14.48.11.61.32.72.82.72.92.62.52.02.31.6-0.82.40.00.0
Intraocular pressure0.30.42.31.50.50.60.40.80.70.30.60.60.4-0.5-0.80.50.00.0
Delta distance traveled before/after self-admin3.03.27.0-1.8-1.6-2.2-2.2-2.3-2.7-2.4-1.7-1.7-1.6-1.50.4-2.10.00.0
Delta ambulatory time before/after self-admin1.82.24.7-1.8-1.1-1.9-1.9-2.0-2.2-1.9-1.4-1.4-1.2-0.90.6-1.80.00.0
Parametrial fat weight0.20.51.6-1.0-1.3-0.6-0.7-0.30.2-0.2-0.9-1.1-1.30.20.90.20.00.0
Pavlov. Cond. lever latency2.63.36.7-1.0-2.6-2.1-2.2-1.9-1.9-2.2-1.9-2.0-2.3-1.70.3-2.00.00.0
Pavlov. Cond. magazine entry latency0.91.14.61.32.10.91.10.90.50.71.31.31.60.3-0.60.20.00.0
Pavlov. Cond. change in total contacts0.20.21.4-0.41.20.40.50.30.00.30.50.60.80.2-0.30.10.00.0
Pavlov. Cond. index score2.22.87.31.22.71.82.01.91.51.91.81.92.31.5-0.41.50.00.0
Pavlov. Cond. latency score2.32.97.60.92.81.92.01.91.62.01.92.02.31.5-0.41.50.00.0
Pavlov. Cond. lever contacts2.93.56.50.62.32.12.21.92.22.51.71.82.12.20.12.50.00.0
Pavlov. Cond. magazine entry number0.60.83.3-1.5-1.8-0.8-0.9-0.9-0.5-0.6-0.9-1.1-1.2-0.40.4-0.20.00.0
Pavlov. Cond. intertrial magazine entries0.20.31.31.0-0.90.10.1-0.20.2-0.3-0.0-0.2-0.5-1.1-0.90.10.00.0
Pavlov. Cond. lever-magazine prob. diff.2.32.87.31.42.71.92.01.91.61.81.91.92.31.4-0.51.40.00.0
Pavlov. Cond. response bias1.51.95.21.52.31.51.61.51.31.51.41.51.81.1-0.31.20.00.0
Pavlov. Cond. lever latency0.30.41.4-0.80.10.40.40.20.81.00.20.00.51.20.71.10.00.0
Pavlov. Cond. magazine entry latency0.00.10.2-0.40.20.20.20.00.10.20.00.30.20.20.30.40.00.0
Pavlov. Cond. change in total contacts0.40.71.8-0.3-0.5-0.9-0.9-0.8-1.3-1.3-0.6-0.5-0.7-1.0-0.3-1.30.00.0
Pavlov. Cond. index score0.10.10.40.20.0-0.3-0.4-0.3-0.6-0.6-0.4-0.0-0.3-0.6-0.1-0.60.00.0
Pavlov. Cond. latency score0.20.30.60.0-0.2-0.5-0.6-0.5-0.8-0.8-0.5-0.2-0.5-0.8-0.0-0.70.00.0
Pavlov. Cond. lever contacts0.30.31.20.6-0.1-0.4-0.5-0.3-0.7-0.9-0.3-0.1-0.6-1.1-0.5-1.10.00.0
Pavlov. Cond. magazine entry number0.00.00.20.4-0.0-0.2-0.1-0.1-0.2-0.20.1-0.20.0-0.1-0.2-0.40.00.0
Pavlov. Cond. intertrial magazine entries0.40.72.51.51.60.70.70.90.70.80.80.81.00.6-0.1-0.00.00.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.40.30.0-0.3-0.4-0.3-0.5-0.5-0.3-0.0-0.3-0.6-0.1-0.50.00.0
Pavlov. Cond. response bias0.10.10.40.60.50.10.00.2-0.2-0.30.10.4-0.0-0.5-0.4-0.50.00.0
Time in closed arm before self-admin0.10.10.50.0-0.3-0.3-0.3-0.3-0.2-0.1-0.4-0.4-0.20.30.70.20.00.0
Time in closed arm after self-admin0.20.21.6-1.3-0.9-0.2-0.2-0.5-0.2-0.1-0.4-0.4-0.30.20.50.30.00.0
Time in open arm before self-admin0.30.31.00.81.00.30.40.3-0.1-0.00.70.60.7-0.1-0.9-0.30.00.0
Time in open arm after self-admin0.20.30.80.80.2-0.6-0.30.0-0.8-0.8-0.2-0.3-0.3-0.9-0.3-0.70.00.0
Bone: periosteal estimation1.32.77.4-2.4-1.0-2.0-1.9-1.6-1.3-0.7-2.1-2.2-1.61.32.7-0.40.00.0
Bone: periosteal perimeter0.30.52.4-1.20.2-0.5-0.4-0.2-0.10.3-0.7-0.7-0.21.31.60.10.00.0
Bone: post-yield work0.60.94.80.20.40.0-0.10.50.91.1-0.8-0.5-0.22.21.91.30.00.0
Progressive ratio test 1 active lever presses0.10.10.4-0.2-0.6-0.10.30.3-0.2-0.10.1-0.1-0.00.1-0.10.60.00.0
Progressive ratio test 1 breakpoint0.10.10.4-0.3-0.7-0.10.20.2-0.2-0.20.0-0.2-0.10.2-0.10.60.00.0
Progressive ratio test 1 inactive lever presses0.10.10.4-0.1-0.60.30.40.50.30.10.40.10.10.2-0.20.10.00.0
Progressive ratio test 2 active lever presses0.40.51.30.80.40.71.00.90.30.11.20.90.9-0.5-1.1-0.10.00.0
Progressive ratio test 2 breakpoint0.50.51.50.80.40.70.90.90.2-0.01.20.90.9-0.6-1.2-0.30.00.0
Progressive ratio test 2 inactive lever presses0.10.20.8-0.8-0.20.30.70.60.30.50.30.20.40.50.30.90.00.0
Incentive Sensitization - Responses0.50.71.61.01.10.80.90.70.30.21.31.11.2-0.7-1.1-0.60.00.0
Incentive Sensitization - Breakpoint0.60.81.81.11.10.91.00.80.40.31.41.21.2-0.7-1.2-0.60.00.0
Sum of active levers in priming session hrs 5-60.10.10.30.4-0.0-0.3-0.2-0.6-0.3-0.3-0.2-0.1-0.1-0.40.30.20.00.0
Progressive ratio3.14.98.0-2.8-2.4-2.7-2.8-2.7-2.5-2.4-2.3-2.5-2.6-1.20.8-2.30.00.0
Food seeking constrained by brief footshock0.20.31.00.3-0.3-0.5-0.4-0.4-0.7-0.8-0.3-0.2-0.6-1.0-0.3-0.50.00.0
Seeking ratio, punishment vs. effort1.62.44.92.21.81.81.91.91.51.51.71.91.80.6-0.61.40.00.0
Retroperitoneal fat weight0.00.20.7-0.8-0.40.30.40.30.60.50.1-0.1-0.1-0.10.30.70.00.0
Reaction time number correct0.71.43.6-0.6-1.9-1.4-1.3-1.1-1.4-1.6-1.0-1.4-1.3-1.1-0.4-1.30.00.0
Reaction time mean minus median0.82.16.21.32.51.61.51.81.81.81.11.51.41.3-0.41.30.00.0
Reaction time mean minus median AUC0.92.24.81.32.21.71.71.81.91.91.21.61.51.3-0.51.70.00.0
Reaction time num false alarms0.10.10.5-0.70.70.30.1-0.10.00.30.40.50.60.2-0.3-0.30.00.0
Reaction time num false alarms AUC0.10.21.2-1.10.6-0.0-0.2-0.4-0.4-0.00.20.30.40.0-0.3-0.80.00.0
Reaction time trials correct on left0.71.43.6-0.6-1.9-1.4-1.3-1.1-1.4-1.6-1.0-1.4-1.3-1.1-0.4-1.30.00.0
Reaction time trials on left0.81.43.5-0.6-1.9-1.5-1.3-1.2-1.4-1.6-1.0-1.4-1.3-1.1-0.4-1.30.00.0
Reaction time mean2.33.77.81.42.32.01.92.22.72.81.11.51.62.60.92.70.00.0
Reaction time mean AUC2.23.57.21.52.32.01.92.12.62.71.11.51.52.40.72.60.00.0
Median of all reaction times2.02.86.71.11.71.71.61.82.42.50.81.11.22.41.02.60.00.0
Reaction time omissions1.21.84.10.91.91.41.31.31.92.00.91.11.21.60.51.80.00.0
Reaction time false alarm rate0.30.52.4-0.61.50.70.50.20.30.80.60.91.00.7-0.00.10.00.0
Reaction time premature initiation rate0.60.92.9-1.7-1.3-0.8-0.9-1.1-0.4-0.3-1.1-1.1-1.00.21.30.50.00.0
Reaction time premature initiations1.32.25.5-2.0-2.3-1.7-1.7-1.9-1.3-1.3-1.7-1.9-1.8-0.51.1-0.30.00.0
Std. dev. reaction times0.91.75.40.92.31.41.21.41.61.80.71.21.21.50.51.40.00.0
Reaction time trials completed0.81.43.5-0.6-1.9-1.5-1.3-1.2-1.4-1.6-1.0-1.4-1.3-1.1-0.4-1.30.00.0
Reaction time trials AUC0.61.23.3-0.5-1.8-1.3-1.2-1.0-1.2-1.4-0.9-1.3-1.2-1.0-0.4-1.20.00.0
Run reversals in cocaine runway, females0.10.10.50.2-0.7-0.3-0.1-0.0-0.2-0.4-0.0-0.3-0.2-0.3-0.30.00.00.0
Run reversals in cocaine runway, males0.30.30.9-0.51.00.50.50.50.70.80.30.40.60.60.40.60.00.0
Latency to leave start box in cocaine runway1.01.22.3-0.90.71.21.41.01.31.51.10.91.41.40.31.40.00.0
Latency to leave start box in cocaine runway, F0.81.01.8-0.20.81.21.31.01.21.31.11.01.31.0-0.11.30.00.0
Latency to leave start box in cocaine runway, M0.30.32.1-1.5-0.10.30.30.20.40.60.20.10.40.90.60.40.00.0
Std. dev. time between licks in bursts0.50.73.0-0.40.80.10.0-0.30.61.1-0.4-0.10.21.71.71.10.00.0
Total sessions with >9 infusions0.30.31.0-0.4-0.6-0.6-0.3-0.1-1.0-1.0-0.2-0.3-0.3-0.8-0.9-0.30.00.0
Short access day 1 total inactive lever presses0.20.32.2-1.5-0.3-0.20.2-0.1-0.10.2-0.4-0.4-0.10.60.41.20.00.0
Short access day 10 total inactive lever presses0.41.11.90.51.31.31.21.41.41.41.21.11.31.0-0.10.20.00.0
Short access day 1 total infusions0.10.10.6-0.0-0.3-0.10.30.4-0.3-0.2-0.1-0.0-0.0-0.0-0.10.70.00.0
Short access day 10 total infusions0.10.10.60.1-0.10.20.40.4-0.1-0.30.40.40.2-0.7-0.80.10.00.0
Short access total infusions0.10.10.4-0.4-0.6-0.10.30.2-0.5-0.50.0-0.0-0.1-0.5-0.60.50.00.0
Short access day 1 locomotion1.11.43.11.41.41.41.31.81.21.21.31.41.30.5-0.80.70.00.0
Short access day 10 total locomotion0.71.44.2-0.8-0.8-1.4-1.6-1.1-1.0-0.6-1.7-1.6-1.30.72.1-0.50.00.0
Short access total locomotion0.10.20.8-0.0-0.2-0.2-0.20.30.10.3-0.5-0.4-0.30.90.80.60.00.0
One hour access (0.3 mA shock)2.32.75.81.42.02.02.01.91.51.32.42.12.30.5-1.70.20.00.0
Compulsive drug intake3.64.39.31.42.62.52.12.52.93.01.92.02.42.50.21.30.00.0
One hour access (shock baseline)0.30.52.50.1-0.3-0.30.1-0.3-0.8-1.10.50.2-0.0-1.6-1.4-0.80.00.0
Social response proportion0.70.81.9-0.7-1.0-1.2-0.8-1.0-0.7-0.5-1.3-1.4-1.00.81.40.40.00.0
Social responses0.81.02.1-1.1-1.0-1.3-1.1-1.5-1.2-0.9-1.3-1.3-1.1-0.00.9-0.50.00.0
Social time1.21.64.3-0.42.11.31.11.11.72.10.61.01.32.00.81.10.00.0
Soleus weight0.92.814.4-1.60.70.10.10.11.22.0-0.8-0.50.13.83.52.30.00.0
Bone: stiffness0.10.21.0-1.0-0.7-0.4-0.5-0.0-0.2-0.2-0.5-0.6-0.70.10.1-0.40.00.0
Tibialis anterior weight0.10.42.0-0.3-0.8-0.3-0.6-0.9-0.5-0.8-0.4-0.3-0.7-1.4-0.7-0.50.00.0
Time to tail flick, vehicle, before self-admin1.71.83.71.31.91.81.41.41.81.61.71.71.50.1-0.90.20.00.0
Time to tail flick, vehicle, after self-admin0.40.51.30.61.10.80.90.80.80.80.90.71.10.0-0.20.70.00.0
Time to tail flick, test, before self-admin0.30.31.30.50.80.10.10.2-0.3-0.40.60.60.5-0.5-1.2-1.00.00.0
Time to tail flick, test, after self-admin1.31.43.51.61.61.11.20.50.60.31.71.51.3-1.2-1.9-0.20.00.0
Delta time to tail flick, vehicle, before/after SA0.20.10.40.0-0.20.10.50.5-0.3-0.30.50.20.4-0.4-0.70.60.00.0
Delta time to tail flick, test, before/after SA0.50.51.10.90.20.91.00.51.00.70.90.70.6-0.2-0.50.80.00.0
Tibia length1.64.313.9-2.9-1.6-2.1-2.3-1.9-0.9-0.4-3.0-2.7-2.21.93.70.60.00.0
Ambulatory time before self-admin0.10.10.40.30.40.40.30.40.70.60.00.2-0.00.00.10.50.00.0
Ambulatory time after self-admin1.31.53.1-1.4-0.9-1.5-1.5-1.8-1.3-1.1-1.5-1.4-1.4-0.91.0-1.10.00.0
Bone: tissue strength0.70.74.4-2.1-1.1-0.4-0.5-0.7-0.2-0.1-1.0-0.6-0.90.10.70.80.00.0
Total heroin consumption0.00.00.1-0.10.4-0.00.0-0.1-0.00.10.2-0.00.2-0.2-0.1-0.20.00.0
Bone: trabecular number1.72.85.51.91.32.22.11.91.91.32.32.11.7-0.6-2.30.70.00.0
Bone: trabecular spacing2.33.07.1-2.7-1.7-2.2-2.0-1.9-1.8-1.2-2.2-2.2-1.70.62.3-0.50.00.0
Bone: trabecular thickness1.11.43.31.80.91.51.51.41.51.01.51.40.9-0.2-1.50.60.00.0
Bone: trabecular tissue density0.60.93.0-1.7-0.6-1.1-1.0-1.0-1.6-1.4-0.2-0.5-0.3-0.8-0.1-1.20.00.0
Water consumed over 24 hours0.10.10.6-0.80.20.20.0-0.20.20.4-0.30.1-0.20.30.70.40.00.0
Number of responses in last shaping day0.80.92.9-1.7-0.8-1.1-1.1-0.9-1.1-0.5-1.3-1.1-0.70.61.20.20.00.0