Hub : Genes

Afp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_012493.2 0.05 0.03 1.5e-05 0.04 0.03 0.03 0.03 5.6e-05 1.9e-04 1.7e-04 3.7e-04
2 Adipose isoform ratio NM_012493.2 0.05 0.03 2.0e-05 0.04 0.03 0.03 0.03 7.4e-05 3.1e-04 2.0e-04 4.6e-04
3 Adipose alternative TSS XM_039091614.1 0.05 0.03 1.6e-05 0.04 0.03 0.03 0.03 5.8e-05 2.2e-04 2.0e-04 3.7e-04
4 Adipose isoform ratio XM_039091614.1 0.05 0.04 2.2e-05 0.03 0.03 0.03 0.03 1.1e-04 5.0e-04 3.2e-04 7.2e-04
5 Liver gene expression Afp 0.32 0.16 2.6e-04 0 0.02 0.03 0.01 1.5e-01 1.7e-03 1.6e-04 3.2e-02
6 Adipose gene expression Afp 0.64 0.09 0.0e+00 0.46 0.54 0.56 0.55 1.8e-57 6.0e-71 1.0e-75 5.8e-73
7 IL gene expression Afp 0.23 0.12 2.6e-04 0.12 0.15 0.13 0.14 6.7e-04 1.6e-04 4.2e-04 2.7e-04
8 BLA gene expression Afp 0.06 0.04 5.2e-03 0.03 0.03 0 0.03 6.3e-03 7.2e-03 3.3e-01 7.6e-03
9 NAcc gene expression Afp 0.26 0.09 0.0e+00 0.28 0.26 0.27 0.28 1.7e-32 1.2e-29 2.0e-31 4.4e-32
10 PL gene expression Afp 0.26 0.1 0.0e+00 0.25 0.19 0.24 0.25 4.4e-27 5.8e-21 8.2e-26 2.1e-27
11 Brain gene expression Afp 0.13 0.09 3.2e-07 0.08 0.08 0.09 0.08 7.0e-08 1.5e-07 2.3e-08 4.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.52.64.5-2.1-2.12.12.1-1.5-1.90.71.51.4-0.30.5
Area under the delay curve0.60.61.9-0.1-0.10.10.1-0.30.61.0-1.0-1.21.4-1.2
BMI with tail1.54.99.0-3.0-3.03.03.0-1.2-2.90.81.71.9-0.70.9
BMI without tail0.30.61.2-0.7-0.70.70.7-0.8-1.1-0.20.50.9-0.90.7
Body weight0.41.73.31.51.5-1.4-1.41.00.8-1.80.10.6-1.81.3
Weight adjusted by age0.30.31.5-0.1-0.10.10.10.7-0.3-0.31.20.3-0.60.7
Bone surface0.81.52.7-0.9-0.91.01.0-0.9-1.3-0.71.61.6-1.31.5
Bone volume0.61.01.5-1.2-1.21.21.2-0.4-1.1-0.01.21.2-0.70.8
Breakpoint value in progressive ratio session0.10.20.40.20.2-0.2-0.20.3-0.1-0.60.60.5-0.60.5
Number of licking bursts0.91.02.81.21.2-1.2-1.21.71.4-0.7-0.3-0.5-0.2-0.0
Context. condit. distance diff. score2.22.66.2-1.7-1.71.71.7-0.5-0.42.5-1.0-1.22.0-2.1
Locomotion velocity, session 10.60.61.1-0.9-0.90.90.91.10.21.0-0.4-0.30.8-0.8
Locomotion distance, session 11.51.94.2-1.6-1.61.51.50.4-0.22.1-1.1-0.81.6-1.6
Locomotion velocity, session 20.30.41.7-0.5-0.50.50.51.30.20.6-0.3-0.20.5-0.6
Locomotion distance, session 20.81.12.3-0.6-0.60.60.61.10.71.4-1.2-1.11.5-1.4
Locomotion velocity, session 31.01.12.7-0.9-0.90.90.90.40.11.6-1.0-1.11.3-1.5
Locomotion distance, session 31.81.93.4-1.9-1.91.81.80.7-0.61.9-0.3-0.51.2-1.3
Stereotopy head waving bouts, day 30.50.61.10.20.2-0.2-0.21.00.80.7-1.0-1.00.9-1.0
Stereotopy head waving duration, day 30.40.51.0-0.2-0.20.20.2-0.60.21.0-0.9-1.01.0-1.0
Locomotion velocity, session 70.70.81.9-0.8-0.80.80.8-0.5-0.11.4-0.8-0.81.3-1.2
Locomotion distance, session 70.40.50.9-0.8-0.80.70.7-0.7-0.20.9-0.3-0.40.8-0.7
Stereotopy head waving bouts, day 70.20.20.7-0.4-0.40.50.50.8-0.40.30.30.4-0.0-0.1
Stereotopy head waving duration, day 70.00.10.50.00.00.00.00.70.10.2-0.0-0.00.1-0.2
Locomotion velocity, session 84.75.69.5-3.1-3.13.13.1-1.9-1.73.0-0.3-0.62.2-1.8
Locomotion distance, session 82.84.29.2-2.4-2.42.42.4-0.3-0.63.0-1.0-1.22.4-2.3
Degree of sensitization distance0.70.71.21.11.1-1.0-1.0-1.10.2-1.10.10.2-0.70.8
Degree of sensitization stereotypy0.10.11.00.20.2-0.2-0.21.00.2-0.20.00.2-0.10.0
Conditioned locomotion0.60.86.5-0.6-0.60.60.6-2.5-0.40.50.2-0.10.4-0.1
Cocaine response after cond. corrected0.20.20.40.70.7-0.7-0.70.60.3-0.3-0.5-0.2-0.20.0
Cocaine response after cond. not corrected0.20.20.5-0.0-0.00.00.00.3-0.5-0.40.30.6-0.70.6
Cocaine response before conditioning1.41.72.7-1.4-1.41.41.4-0.8-1.6-0.31.61.7-1.11.2
Saline control response0.30.40.7-0.9-0.90.90.9-0.2-0.70.40.00.60.10.1
Bone: connectivity density2.23.46.2-2.3-2.32.42.4-2.5-2.11.11.31.10.20.2
Bone: cortical apparent density0.30.41.3-0.3-0.30.20.21.10.50.7-0.4-0.50.8-0.8
Bone: cortical area0.71.01.8-1.2-1.21.21.2-0.7-1.30.21.01.2-0.40.7
Bone: cortical porosity0.20.21.8-0.2-0.20.20.2-1.4-0.50.10.20.0-0.00.1
Bone: cortical porosity0.30.32.2-0.2-0.20.20.2-1.5-0.6-0.10.50.3-0.30.4
Bone: cortical thickness2.33.86.5-2.5-2.52.62.6-1.0-2.50.91.81.8-0.20.7
Bone: cortical thickness0.50.61.9-0.4-0.40.40.40.2-1.2-0.60.91.4-0.91.0
Bone: cortical tissue density0.30.31.5-0.2-0.20.10.11.20.50.6-0.4-0.50.7-0.8
Condit. Reinf. active minus inactive responses0.70.82.21.11.1-1.1-1.11.51.2-0.7-0.1-0.3-0.20.0
Condit. Reinf. active-inactive response ratio0.80.91.91.11.1-1.1-1.11.41.2-0.90.2-0.2-0.40.2
Condit. Reinf. active responses0.40.42.40.50.5-0.5-0.51.50.9-0.1-0.5-0.50.1-0.3
Condit. Reinf. inactive responses0.10.10.3-0.5-0.50.50.50.4-0.30.4-0.20.00.1-0.1
Incentive salience index mean0.10.10.30.20.2-0.3-0.30.60.50.2-0.3-0.40.3-0.5
Condit. Reinf. lever presses0.30.40.7-0.8-0.80.80.8-0.6-0.80.60.10.30.2-0.2
Condit. Reinf. active minus inactive responses0.30.32.8-0.3-0.30.30.31.70.10.4-0.20.10.4-0.4
Condit. Reinf. active-inactive response ratio0.90.92.00.70.7-0.7-0.70.8-0.3-1.41.01.1-1.41.3
Condit. Reinf. active responses0.71.06.40.00.0-0.0-0.02.50.90.7-0.9-0.71.0-1.1
Condit. Reinf. inactive responses0.91.12.1-0.4-0.40.40.41.30.71.3-1.3-1.11.4-1.5
Condit. Reinf. lever presses0.60.81.31.01.0-1.0-1.00.61.10.0-1.2-0.80.4-0.6
Condit. Reinf. lever reinforcers received0.71.05.4-0.0-0.00.00.02.30.90.8-0.9-0.71.1-1.1
Conditioned reinforcement - actives1.11.13.50.90.9-0.9-0.91.91.40.2-0.8-1.01.1-0.9
Conditioned reinforcement - inactives0.50.62.00.80.8-0.8-0.80.20.2-1.00.20.3-1.40.8
Conditioned locomotion2.63.16.42.22.2-2.2-2.21.42.5-0.6-1.8-1.6-0.0-0.5
Patch foraging indifference point 0 sec0.50.71.7-0.7-0.70.70.7-0.6-0.11.3-1.2-1.00.8-1.1
Patch foraging indifference point AUC0.60.75.40.10.1-0.1-0.1-2.30.20.6-0.8-0.80.5-0.7
Delay disc. indifference point, 0s delay0.20.21.10.00.0-0.0-0.01.10.60.2-0.5-0.40.4-0.5
Delay disc. indifference point, 16s delay0.50.51.2-0.6-0.60.60.6-0.6-0.00.9-0.6-0.71.1-0.9
Delay disc. indifference point, 2s delay0.60.61.60.40.4-0.4-0.4-0.30.80.7-1.3-1.21.1-1.0
Delay disc. indifference point, 24s delay1.41.43.01.01.0-1.0-1.0-0.11.40.7-1.5-1.71.3-1.5
Delay disc. indifference point, 4s delay1.92.04.9-0.3-0.30.30.30.51.31.9-1.6-2.02.2-2.2
Delay disc. indifference point, 8s delay0.20.20.6-0.5-0.50.50.5-0.1-0.10.50.2-0.10.8-0.3
Indifference point function ln k0.40.64.4-0.3-0.30.30.32.1-0.5-0.40.60.8-0.40.6
Indifference point function log k0.40.64.4-0.3-0.30.30.32.1-0.5-0.40.60.8-0.40.6
Patch foraging total patch changes 0 sec0.50.81.7-0.6-0.60.60.6-0.9-0.11.3-1.1-1.00.9-1.1
Patch foraging total patch changes 12 sec1.01.32.9-0.3-0.30.40.4-1.10.41.6-1.4-1.41.7-1.7
Patch foraging total patch changes 18 sec0.10.10.60.40.4-0.4-0.40.10.7-0.2-0.2-0.5-0.2-0.1
Patch foraging total patch changes 24 sec1.72.05.3-0.5-0.50.50.5-0.90.52.1-2.1-1.81.8-2.3
Patch foraging total patch changes 6 sec1.21.83.8-0.6-0.60.60.6-1.90.31.9-1.5-1.71.6-1.8
Patch foraging time to switch 0 sec0.30.41.5-0.3-0.30.30.31.1-0.4-0.51.21.0-0.40.7
Patch foraging water rate 0 sec0.30.41.50.40.4-0.4-0.4-1.20.30.3-1.2-0.80.1-0.4
Patch foraging water rate 12 sec0.40.72.5-0.4-0.40.40.4-1.6-0.11.1-1.0-0.90.7-0.9
Patch foraging water rate 18 sec0.40.51.60.50.5-0.5-0.51.20.70.3-1.3-0.70.4-0.6
Patch foraging water rate 24 sec0.81.22.31.41.4-1.4-1.41.51.2-0.9-0.6-0.4-0.70.2
Patch foraging water rate 6 sec0.71.12.60.90.9-0.9-0.90.11.20.6-1.6-1.51.1-1.1
Seeking ratio, delayed vs. immediate footshock0.40.51.50.20.2-0.2-0.2-0.10.60.7-1.2-1.20.7-1.0
Distance traveled before self-admin1.81.93.11.81.8-1.8-1.80.11.7-0.2-1.7-1.30.7-0.9
Distance traveled after self-admin4.95.410.72.62.6-2.6-2.63.03.3-0.1-2.3-2.01.1-1.4
Extensor digitorum longus weight5.521.841.5-5.8-5.85.95.9-1.9-6.41.04.95.1-1.52.3
Bone: elastic displacement1.82.04.1-1.5-1.51.51.50.1-1.9-0.21.82.0-0.91.2
Bone: elastic work1.92.45.5-1.5-1.51.51.50.3-1.9-0.52.12.4-1.21.5
Bone: endosteal estimation1.53.35.62.42.4-2.3-2.32.32.0-1.5-1.1-0.6-0.60.3
Bone: endosteal perimeter0.51.12.11.41.4-1.4-1.40.41.0-1.3-0.20.1-0.90.7
Epididymis fat weight0.30.71.00.80.8-0.9-0.90.90.90.0-1.0-0.90.9-0.5
Delta time in closed arm before/after self-admin0.20.21.3-0.3-0.30.30.3-1.1-0.40.30.30.30.4-0.3
Delta time in open arm before/after self-admin0.50.52.70.50.5-0.5-0.5-1.60.30.1-0.8-0.80.6-0.2
Diff in mean of infusions in LGA sessions1.31.43.00.50.5-0.5-0.51.2-0.3-1.71.61.5-1.51.7
Delay discount exponential model param0.70.82.20.00.0-0.0-0.00.4-0.7-1.01.01.3-1.51.3
Extinction: sum of active levers before priming0.70.71.80.50.5-0.5-0.5-1.30.80.6-1.3-0.90.5-0.9
Active lever presses in extinction session 61.71.63.01.71.7-1.7-1.71.21.2-1.3-0.2-0.1-1.00.5
Bone: final force0.30.41.00.50.5-0.5-0.50.70.0-1.00.50.6-0.80.9
Bone: final moment0.40.61.30.90.9-0.9-0.91.10.5-1.10.20.3-0.70.8
Food consumed during 24 hour testing period0.30.40.6-0.8-0.80.80.8-0.8-0.80.50.20.40.1-0.0
Glucose1.11.63.81.31.3-1.2-1.22.01.60.1-1.4-1.30.7-1.0
Heart weight0.20.31.10.20.2-0.1-0.1-1.0-0.3-0.60.30.2-1.00.9
Delay discount hyperbolic model param1.11.13.10.10.1-0.1-0.10.4-0.8-1.31.31.5-1.81.6
Intermittent access intake day 1-15 change0.70.73.40.50.5-0.5-0.51.80.4-1.00.40.2-1.00.9
Intermittent access intake escalation1.41.45.61.11.1-1.1-1.12.41.1-1.30.0-0.1-1.00.9
Intermittent access intake escalation 22.32.34.02.02.0-2.0-2.01.41.6-1.5-0.8-0.5-1.10.7
Intermitt. access day 1 inactive lever presses3.03.26.9-2.6-2.62.62.6-0.8-1.71.90.20.20.4-0.6
Intermitt. access day 15 inactive lever presses1.41.65.00.00.0-0.0-0.0-0.6-1.0-1.51.61.5-2.22.0
Intermitt. access escalation Index1.21.12.20.50.5-0.5-0.51.3-0.4-1.51.51.4-0.91.3
Intermittent access day 1 total infusions0.80.91.61.11.1-1.1-1.1-0.61.20.2-1.3-1.00.5-0.8
Intermittent access day 15 total infusions1.92.14.01.91.9-1.9-1.91.12.0-0.7-1.2-1.2-0.1-0.2
Intermittent access terminal intake (last 3 days)3.33.66.82.62.6-2.6-2.60.92.4-1.0-1.7-1.4-0.2-0.2
Intermittent access total infusions1.82.03.71.91.9-1.9-1.90.31.9-0.6-1.2-1.1-0.1-0.3
Intermittent access day 1 locomotion0.70.71.61.01.0-1.0-1.00.61.3-0.1-1.0-0.90.1-0.5
Intermittent access day 15 total locomotion2.93.17.41.41.4-1.4-1.41.42.40.8-2.5-2.71.3-1.6
Intermittent access total locomotion2.12.44.61.91.9-1.9-1.91.62.1-0.4-1.7-1.50.1-0.5
Intermittent access standard deviation0.30.41.60.20.2-0.2-0.2-0.60.80.5-0.8-1.30.2-0.5
Left kidney weight0.71.93.21.81.8-1.8-1.8-1.51.1-1.2-0.7-0.8-1.00.8
Right kidney weight1.02.95.52.32.3-2.4-2.4-1.31.4-1.6-0.9-0.8-1.20.9
Cocaine induced anxiety1.82.14.71.11.1-1.1-1.11.70.2-2.21.41.5-1.61.8
Post-drug Anxiety0.60.71.11.01.0-1.0-1.01.00.7-1.1-0.10.3-0.20.5
Baseline Anxiety1.81.96.2-0.3-0.30.30.30.10.61.8-1.6-1.62.5-2.3
Tail length2.37.013.83.73.7-3.7-3.71.92.8-2.5-1.0-0.7-1.30.8
Length with tail3.613.125.55.05.0-5.0-5.02.64.4-2.7-2.2-1.9-1.00.3
Length without tail1.94.19.02.52.5-2.5-2.51.73.0-0.5-1.8-2.00.6-0.9
Times rat made contact with spout1.61.814.2-0.8-0.80.80.8-3.8-1.60.30.20.5-0.20.4
Lifetime Intake1.41.62.91.71.7-1.7-1.70.21.7-0.5-1.1-1.0-0.1-0.3
Liver weight, left0.61.03.50.40.4-0.4-0.40.50.81.1-1.9-1.11.3-1.4
Liver weight, right0.81.44.10.40.4-0.4-0.4-0.20.81.4-1.6-1.62.0-1.7
Locomotor activity0.20.31.40.20.2-0.2-0.2-0.10.50.6-1.2-0.60.7-0.7
Locomotor testing distance0.50.92.5-0.8-0.80.80.8-0.10.01.6-1.1-0.91.3-1.3
Locomotor testing rearing0.30.51.2-0.5-0.50.50.50.20.31.1-0.7-0.90.6-1.0
Locomotion in novel chamber0.70.92.2-0.3-0.30.30.3-0.10.51.3-1.1-1.51.5-1.3
Locomotion in novel chamber post-restriction0.70.82.30.80.8-0.8-0.8-0.61.00.3-1.1-1.50.5-0.8
Fecal boli incidents, locomotor time 10.30.31.90.30.3-0.3-0.3-0.4-0.3-0.61.40.4-0.20.7
Change in fecal boli incidents, locomotor task1.31.23.51.21.2-1.2-1.21.90.7-1.30.50.4-1.00.8
Time >=10cm from walls, locomotor time 11.01.01.71.01.0-1.0-1.00.90.2-1.30.90.9-1.11.2
Bouts of movement, locomotor time 10.10.10.30.50.5-0.5-0.50.10.6-0.0-0.1-0.40.1-0.1
Total resting periods, locomotor time 10.30.30.60.80.8-0.8-0.80.40.7-0.2-0.1-0.50.1-0.1
Rest time, locomotor task time 10.40.51.01.01.0-1.0-1.00.60.5-0.70.20.0-0.20.2
Distance moved, locomotor task time 10.20.30.7-0.7-0.70.70.7-0.8-0.30.2-0.20.0-0.20.2
Vertical activity count, locomotor time 10.60.61.70.50.5-0.5-0.50.21.10.4-1.3-1.20.7-0.9
Time >=10cm from walls, locomotor time 20.50.51.1-0.2-0.20.20.20.3-0.9-0.70.91.0-1.01.1
Bouts of movement, locomotor time 21.11.23.10.50.5-0.5-0.50.61.11.0-1.5-1.81.4-1.5
Total resting periods, locomotor time 20.80.82.20.50.5-0.5-0.50.30.90.7-1.4-1.51.1-1.2
Rest time, locomotor task time 20.60.72.20.80.8-0.8-0.8-1.50.30.3-0.8-0.90.6-0.6
Distance moved, locomotor task time 21.01.21.8-1.3-1.31.31.30.5-1.1-0.30.81.3-1.11.0
Vertical activity count, locomotor time 20.40.54.8-0.1-0.10.10.12.20.4-0.1-0.4-0.0-0.2-0.1
Light reinforcement 10.40.63.7-0.1-0.10.20.2-1.90.00.8-0.9-1.00.5-0.8
Light reinforcement 21.62.212.2-1.1-1.11.11.1-3.5-0.81.6-0.8-0.91.0-1.0
Bone: marrow area1.32.95.12.22.2-2.2-2.22.31.9-1.4-1.0-0.5-0.60.4
Bone: maximum diameter0.40.81.90.00.00.00.0-0.6-0.7-1.01.11.3-1.31.4
Bone: maximum force0.10.20.50.20.2-0.2-0.2-0.1-0.3-0.60.60.6-0.60.7
Bone: maximum moment0.10.30.50.60.6-0.6-0.60.30.1-0.70.20.3-0.50.6
Mean time between licks in bursts0.81.22.41.51.5-1.5-1.50.80.8-1.2-0.0-0.0-0.70.5
Mean num. licks in bursts2.12.514.1-1.4-1.41.41.4-3.8-2.00.90.20.50.3-0.0
Cd content in liver1.21.33.00.50.5-0.5-0.5-0.6-0.8-1.61.41.3-1.71.7
Co content in liver1.21.43.01.31.3-1.3-1.31.31.7-0.1-1.0-1.30.5-0.8
Cu content in liver0.60.71.6-0.4-0.40.30.3-0.80.21.3-1.2-0.71.2-1.2
Fe content in liver0.40.40.7-0.8-0.80.80.8-0.6-0.70.40.80.5-0.40.0
K content in liver3.73.77.9-1.2-1.21.21.2-2.3-0.02.8-1.9-2.02.7-2.5
Mg content in liver2.22.26.3-0.5-0.50.50.5-2.50.22.0-1.5-1.82.1-1.9
Mn content in liver0.91.02.0-1.4-1.41.41.41.0-0.90.9-0.00.60.6-0.4
Na content in liver4.64.811.2-1.2-1.21.21.2-2.00.23.3-2.5-2.23.3-3.2
Rb content in liver1.11.43.91.41.4-1.3-1.32.01.2-1.20.30.1-0.70.5
Se content in liver1.82.24.4-1.3-1.31.21.2-2.1-0.32.1-1.2-1.21.8-1.7
Sr content in liver1.31.22.7-0.3-0.30.30.3-1.0-1.0-1.11.61.6-1.51.5
Zn content in liver0.80.92.3-0.5-0.50.60.60.30.31.5-1.0-0.91.3-1.4
Bone: minimum diameter2.95.410.43.23.2-3.2-3.21.62.9-1.6-1.8-1.3-0.50.1
Time in familiar zone, hab. session 12.01.93.4-1.7-1.71.71.7-1.2-1.11.8-0.2-0.41.4-1.2
Time in novel zone, hab. session 14.64.58.42.92.9-2.9-2.91.62.0-2.5-0.2-0.1-1.51.2
Total zone transitions, hab. session 11.92.66.5-0.4-0.40.40.40.61.12.3-2.3-2.12.4-2.5
Total locomotion distance, hab. session 12.33.37.3-0.7-0.70.70.7-1.60.42.7-2.2-2.22.7-2.7
Locomotion velocity, hab. session 12.63.68.6-1.3-1.31.31.3-1.7-0.12.9-1.9-1.92.7-2.6
Time in familiar zone, hab. session 20.60.76.3-0.3-0.30.30.3-2.5-0.60.40.1-0.00.1-0.0
Time in novel zone, hab. session 21.21.27.70.80.8-0.8-0.82.80.9-1.00.00.2-0.50.4
Total zone transitions, hab. session 20.10.10.3-0.3-0.30.30.30.60.00.4-0.4-0.20.5-0.3
Total locomotion distance, hab. session 20.30.30.8-0.3-0.30.30.3-0.50.10.8-0.8-0.70.9-0.7
Locomotion velocity, hab. session 20.60.92.0-0.6-0.60.50.5-0.60.11.4-1.2-1.01.4-1.2
Novel to familiar place preference ratio0.30.30.70.00.00.00.0-0.80.10.6-0.7-0.80.7-0.7
Novelty place preference0.30.31.10.20.2-0.2-0.2-1.10.20.5-0.8-0.80.7-0.7
Time in novel zone, NPP test0.50.51.10.40.4-0.4-0.4-0.70.50.5-1.0-1.10.8-0.9
Total zone transitions, NPP test0.50.71.7-1.2-1.21.11.11.3-0.60.60.40.50.2-0.1
Total locomotion distance, NPP test0.81.12.2-1.2-1.21.21.2-1.0-0.61.5-0.5-0.51.1-1.0
Locomotion velocity, NPP test0.91.22.2-1.5-1.51.41.4-0.8-0.91.4-0.2-0.20.9-0.8
Intraocular pressure0.81.12.21.41.4-1.5-1.50.00.4-1.4-0.30.2-1.00.7
Delta distance traveled before/after self-admin0.91.08.50.40.4-0.4-0.42.91.0-0.0-0.1-0.30.4-0.3
Delta ambulatory time before/after self-admin0.91.010.10.20.2-0.2-0.23.20.8-0.10.20.00.2-0.2
Parametrial fat weight0.20.51.50.70.7-0.7-0.7-0.10.0-1.00.20.2-1.20.8
Pavlov. Cond. lever latency0.40.51.10.30.3-0.3-0.3-0.1-0.2-1.01.00.9-1.01.0
Pavlov. Cond. magazine entry latency0.40.51.3-0.4-0.40.40.4-0.30.01.1-0.8-0.81.2-1.0
Pavlov. Cond. change in total contacts0.20.30.8-0.1-0.10.10.10.90.30.6-0.6-0.50.7-0.7
Pavlov. Cond. index score0.81.02.4-0.9-0.90.90.90.2-0.11.5-1.1-0.81.5-1.3
Pavlov. Cond. latency score0.60.81.7-0.9-0.90.90.90.0-0.31.3-0.8-0.61.2-1.0
Pavlov. Cond. lever contacts0.50.51.1-0.5-0.50.50.50.90.21.0-0.7-0.61.1-1.0
Pavlov. Cond. magazine entry number0.50.61.40.60.6-0.6-0.6-0.40.0-1.20.80.7-1.21.1
Pavlov. Cond. intertrial magazine entries0.50.71.60.10.10.10.10.80.71.1-0.9-1.01.2-1.3
Pavlov. Cond. lever-magazine prob. diff.0.91.12.6-0.9-0.90.90.90.1-0.11.6-1.1-0.81.5-1.4
Pavlov. Cond. response bias0.70.81.9-0.1-0.10.10.10.80.61.2-1.3-1.11.4-1.4
Pavlov. Cond. lever latency0.20.32.5-0.2-0.20.10.11.60.30.10.10.10.1-0.2
Pavlov. Cond. magazine entry latency0.60.71.40.90.9-0.9-0.9-0.70.1-1.20.20.3-1.20.9
Pavlov. Cond. change in total contacts0.40.54.4-0.2-0.20.20.2-2.1-0.60.5-0.3-0.00.3-0.2
Pavlov. Cond. index score0.60.72.10.70.7-0.7-0.7-1.5-0.3-1.00.30.5-1.11.1
Pavlov. Cond. latency score0.60.72.00.30.3-0.3-0.3-1.4-0.7-1.00.60.8-1.21.2
Pavlov. Cond. lever contacts0.30.43.40.50.5-0.5-0.5-1.9-0.0-0.0-0.6-0.30.1-0.0
Pavlov. Cond. magazine entry number0.50.61.5-0.5-0.50.50.50.90.21.1-0.5-0.61.2-1.0
Pavlov. Cond. intertrial magazine entries0.10.10.70.10.1-0.1-0.10.80.30.2-0.3-0.30.4-0.4
Pavlov. Cond. lever-magazine prob. diff.0.50.72.40.70.7-0.7-0.7-1.6-0.3-0.90.20.4-1.01.0
Pavlov. Cond. response bias0.40.52.00.90.9-0.9-0.9-1.40.4-0.3-0.6-0.5-0.10.0
Time in closed arm before self-admin0.40.41.7-0.3-0.30.30.31.3-0.6-0.40.10.4-1.20.7
Time in closed arm after self-admin0.80.81.7-1.3-1.31.31.30.0-1.10.8-0.10.40.2-0.3
Time in open arm before self-admin0.20.30.80.50.5-0.5-0.50.90.3-0.40.80.6-0.10.1
Time in open arm after self-admin1.01.13.01.21.2-1.2-1.2-1.70.8-0.1-0.8-1.00.7-0.4
Bone: periosteal estimation0.30.71.70.90.9-0.9-0.91.30.5-1.00.00.4-0.80.8
Bone: periosteal perimeter0.00.10.3-0.1-0.10.10.1-0.5-0.3-0.10.20.4-0.30.3
Bone: post-yield work0.91.32.81.71.7-1.6-1.6-0.90.8-0.8-0.9-0.7-0.30.2
Progressive ratio test 1 active lever presses3.63.86.72.62.6-2.6-2.6-0.12.6-0.5-2.0-1.80.4-0.8
Progressive ratio test 1 breakpoint3.13.25.62.42.4-2.4-2.4-0.12.4-0.4-1.9-1.70.4-0.8
Progressive ratio test 1 inactive lever presses0.50.61.3-0.7-0.70.70.7-1.2-0.41.1-0.6-0.70.4-0.6
Progressive ratio test 2 active lever presses2.52.75.12.12.1-2.1-2.10.22.3-0.4-1.8-1.60.2-0.7
Progressive ratio test 2 breakpoint1.21.42.71.41.4-1.4-1.4-0.11.6-0.0-1.5-1.40.3-0.7
Progressive ratio test 2 inactive lever presses0.50.51.10.80.8-0.8-0.80.11.0-0.1-0.9-0.9-0.2-0.1
Incentive Sensitization - Responses1.41.52.61.61.6-1.6-1.61.11.3-1.2-0.4-0.1-0.80.5
Incentive Sensitization - Breakpoint1.61.62.91.71.7-1.7-1.71.21.4-1.2-0.4-0.2-0.80.5
Sum of active levers in priming session hrs 5-60.20.20.9-0.1-0.10.10.1-0.9-0.10.4-0.6-0.30.2-0.3
Progressive ratio0.20.20.5-0.5-0.50.50.5-0.0-0.70.10.70.6-0.20.1
Food seeking constrained by brief footshock0.20.21.1-0.5-0.50.50.50.3-0.5-0.10.10.5-1.00.2
Seeking ratio, punishment vs. effort0.00.00.20.00.0-0.0-0.0-0.10.2-0.0-0.5-0.2-0.2-0.0
Retroperitoneal fat weight0.51.72.61.61.6-1.6-1.61.61.5-0.6-1.3-1.10.1-0.3
Reaction time number correct0.71.03.31.11.1-1.1-1.11.80.7-1.20.10.2-0.70.7
Reaction time mean minus median0.50.71.31.01.0-1.0-1.0-0.60.1-1.10.10.5-1.00.9
Reaction time mean minus median AUC0.70.91.71.01.0-1.0-1.0-0.9-0.3-1.3-0.10.9-1.21.2
Reaction time num false alarms0.91.32.7-0.6-0.60.60.60.20.61.6-1.4-1.71.7-1.6
Reaction time num false alarms AUC1.11.53.1-0.5-0.50.50.50.50.71.6-1.7-1.71.8-1.7
Reaction time trials correct on left0.71.03.31.11.1-1.1-1.11.80.7-1.20.10.2-0.70.7
Reaction time trials on left0.81.13.51.11.1-1.1-1.11.90.6-1.30.20.3-0.80.8
Reaction time mean0.91.22.71.11.1-1.1-1.10.80.2-1.60.71.0-1.41.3
Reaction time mean AUC0.71.01.91.21.2-1.1-1.11.00.5-1.40.30.6-1.11.0
Median of all reaction times0.81.12.31.11.1-1.1-1.11.20.4-1.50.70.8-1.11.1
Reaction time omissions0.60.92.10.40.4-0.3-0.31.0-0.5-1.30.71.4-1.51.2
Reaction time false alarm rate1.31.83.9-0.9-0.90.80.8-0.60.42.0-1.6-1.71.9-1.9
Reaction time premature initiation rate0.30.40.9-0.6-0.60.60.6-0.5-0.01.0-0.9-0.70.5-0.8
Reaction time premature initiations0.10.20.9-0.0-0.00.00.00.40.30.3-1.0-0.60.1-0.4
Std. dev. reaction times0.40.61.20.90.9-0.9-0.90.40.2-1.1-0.00.6-1.00.8
Reaction time trials completed0.81.13.51.11.1-1.1-1.11.90.6-1.30.20.3-0.80.8
Reaction time trials AUC1.01.54.61.31.3-1.3-1.32.10.8-1.50.30.3-1.00.9
Run reversals in cocaine runway, females0.30.20.9-0.5-0.50.50.50.90.00.6-0.4-0.10.1-0.3
Run reversals in cocaine runway, males1.21.13.2-0.1-0.10.10.1-0.0-1.2-1.31.11.7-1.81.5
Latency to leave start box in cocaine runway1.01.11.91.41.4-1.4-1.40.51.3-0.3-0.8-0.90.5-0.6
Latency to leave start box in cocaine runway, F1.31.42.21.31.3-1.3-1.30.21.40.4-1.5-1.51.1-1.2
Latency to leave start box in cocaine runway, M1.51.43.41.11.1-1.1-1.10.70.0-1.81.21.1-1.61.4
Std. dev. time between licks in bursts0.40.50.70.80.8-0.8-0.80.80.70.0-0.7-0.50.5-0.5
Total sessions with >9 infusions0.50.50.80.90.9-0.9-0.90.60.7-0.9-0.10.1-0.90.5
Short access day 1 total inactive lever presses0.10.10.30.10.1-0.1-0.10.30.40.2-0.2-0.5-0.1-0.1
Short access day 10 total inactive lever presses2.22.45.1-2.3-2.32.32.3-0.5-1.81.01.20.4-0.20.1
Short access day 1 total infusions0.40.51.20.50.5-0.5-0.5-0.50.90.5-0.5-1.10.8-0.8
Short access day 10 total infusions0.70.71.90.80.8-0.8-0.8-0.01.20.3-1.4-1.10.3-0.7
Short access total infusions0.30.40.70.90.9-0.9-0.90.10.7-0.4-0.3-0.2-0.40.1
Short access day 1 locomotion2.02.24.71.71.7-1.7-1.71.32.2-0.0-1.2-1.80.8-0.9
Short access day 10 total locomotion0.40.51.00.60.6-0.6-0.60.91.00.2-0.8-0.90.5-0.5
Short access total locomotion0.60.61.20.90.9-0.9-0.91.11.0-0.3-0.5-0.5-0.2-0.1
One hour access (0.3 mA shock)3.64.28.02.62.6-2.6-2.61.62.8-0.7-1.9-1.90.4-0.6
Compulsive drug intake2.72.85.1-2.3-2.32.32.3-1.1-2.11.01.41.20.30.1
One hour access (shock baseline)5.15.911.03.23.2-3.2-3.21.43.3-0.9-2.2-2.20.3-0.7
Social response proportion0.20.20.30.60.6-0.6-0.6-0.5-0.1-0.4-0.2-0.00.00.3
Social responses0.81.12.30.80.8-0.8-0.80.91.20.5-1.5-1.31.1-1.1
Social time0.20.30.60.80.8-0.7-0.70.40.3-0.5-0.70.1-0.20.2
Soleus weight2.67.816.3-3.9-3.94.04.0-0.3-2.82.81.01.01.7-0.9
Bone: stiffness0.71.12.50.40.4-0.4-0.4-0.10.91.1-1.6-1.61.4-1.5
Tibialis anterior weight2.37.814.6-3.8-3.83.83.8-1.9-3.61.81.92.00.40.2
Time to tail flick, vehicle, before self-admin0.90.92.01.41.4-1.4-1.40.40.8-1.00.0-0.2-0.10.3
Time to tail flick, vehicle, after self-admin1.11.23.0-0.2-0.20.20.21.51.11.2-1.2-0.81.7-1.6
Time to tail flick, test, before self-admin0.10.10.3-0.5-0.50.50.50.1-0.40.40.3-0.10.0-0.1
Time to tail flick, test, after self-admin2.42.54.42.12.1-2.1-2.11.42.0-0.6-1.4-0.80.1-0.8
Delta time to tail flick, vehicle, before/after SA0.90.92.0-1.0-1.01.01.00.60.31.4-1.1-0.30.9-1.2
Delta time to tail flick, test, before/after SA1.51.32.21.41.4-1.4-1.40.31.5-0.1-1.4-0.70.7-1.0
Tibia length1.33.77.22.12.1-2.2-2.22.71.5-2.50.20.7-1.81.6
Ambulatory time before self-admin2.02.14.51.61.6-1.6-1.60.31.80.3-2.1-1.60.9-1.3
Ambulatory time after self-admin4.75.110.02.32.3-2.3-2.33.23.10.1-2.6-2.11.2-1.6
Bone: tissue strength0.50.51.00.60.6-0.6-0.60.00.80.5-0.7-1.00.8-0.9
Total heroin consumption2.22.64.82.12.1-2.1-2.12.22.1-0.8-0.9-0.60.3-0.4
Bone: trabecular number1.01.53.0-1.7-1.71.71.7-1.1-1.21.10.70.60.4-0.3
Bone: trabecular spacing0.10.10.3-0.0-0.0-0.0-0.00.40.10.4-0.4-0.40.6-0.4
Bone: trabecular thickness0.30.40.7-0.8-0.80.80.8-0.5-0.60.40.50.6-0.20.0
Bone: trabecular tissue density0.10.10.50.20.2-0.3-0.30.70.60.2-0.2-0.30.2-0.4
Water consumed over 24 hours0.10.21.4-0.0-0.00.00.0-1.2-0.40.0-0.4-0.20.00.1
Number of responses in last shaping day1.21.23.1-0.9-0.90.90.9-0.80.41.6-0.1-1.51.8-1.3