Hub : Genes

Afp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_012493.2 0.05 0.03 9.9e-06 0.03 0.03 0 0.03 6.4e-04 1.1e-04 7.6e-02 4.0e-04
2 Adipose alternative TSS XM_039091614.2 0.05 0.03 9.0e-06 0.03 0.03 0 0.03 6.8e-04 1.1e-04 7.5e-02 3.2e-04
3 Adipose isoform ratio NM_012493.2 0.06 0.04 1.3e-05 0.02 0.03 0.01 0.02 9.8e-04 2.4e-04 6.2e-02 1.1e-03
4 Adipose isoform ratio XM_039091614.2 0.06 0.04 1.6e-05 0.02 0.03 0 0.02 1.9e-03 4.3e-04 9.8e-02 1.7e-03
5 Adipose gene expression Afp 0.69 0.08 0.0e+00 0.48 0.55 0.56 0.56 1.1e-60 1.7e-73 1.8e-75 2.4e-75
6 Liver gene expression Afp 0.41 0.19 2.1e-04 0 0.02 0.04 0.01 1.9e-01 8.7e-04 1.6e-05 1.1e-02
7 Brain gene expression Afp 0.13 0.09 4.5e-07 0.08 0.08 0.07 0.08 9.2e-08 1.5e-07 2.1e-07 8.3e-08
8 IC gene expression Afp 0.16 0.1 2.2e-04 0.09 0.05 0.02 0.09 1.1e-04 5.0e-03 3.9e-02 1.9e-04
9 pVTA gene expression Afp 0.21 0.1 1.6e-07 0.03 0.1 0.1 0.09 1.9e-03 2.4e-08 2.2e-08 7.8e-08
10 BLA gene expression Afp 0.07 0.04 1.7e-03 0.05 0.04 0.04 0.05 1.5e-03 2.2e-03 5.9e-03 8.0e-04
11 NAcc gene expression Afp 0.2 0.06 0.0e+00 0.24 0.22 0.23 0.24 9.7e-37 7.5e-33 1.8e-34 1.3e-35
12 PL gene expression Afp 0.29 0.11 0.0e+00 0.26 0.24 0.24 0.26 9.6e-28 7.0e-26 5.8e-26 1.0e-28
13 IL gene expression Afp 0.24 0.12 1.9e-04 0.17 0.16 0.1 0.17 6.6e-05 1.3e-04 2.3e-03 6.8e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.22.14.31.9-1.91.9-1.92.11.5-1.2-0.1-1.5-1.0-1.2-0.10.2
Area under the delay curve1.01.13.10.6-0.70.6-0.6-0.3-0.11.31.51.21.31.41.70.9
BMI with tail2.07.014.83.7-3.73.7-3.73.93.1-1.50.5-2.2-0.9-1.50.41.4
BMI without tail0.51.53.81.3-1.31.3-1.31.90.8-1.3-0.4-1.7-0.9-1.3-0.60.0
Body weight0.10.41.9-0.60.6-0.60.6-0.2-0.1-0.5-1.2-0.2-0.3-0.6-1.4-0.2
Weight adjusted by age0.20.41.80.1-0.10.1-0.10.5-0.5-0.5-0.3-1.0-0.9-0.4-0.4-1.3
Bone surface0.71.22.40.3-0.30.3-0.31.30.9-1.5-1.3-1.3-1.5-1.5-1.2-1.1
Bone volume0.40.71.40.9-0.90.9-0.91.20.6-1.0-0.6-0.8-0.9-1.0-0.5-0.3
Breakpoint value in progressive ratio session0.10.20.50.0-0.00.0-0.00.2-0.3-0.7-0.5-0.4-0.5-0.6-0.2-0.4
Number of licking bursts0.50.82.7-1.11.1-1.11.1-1.1-1.70.4-0.31.10.20.4-0.0-0.0
Context. condit. distance diff. score2.63.25.72.4-2.42.4-2.41.01.01.12.10.61.41.12.01.9
Locomotion velocity, session 10.70.81.71.3-1.31.3-1.20.5-0.20.30.71.00.50.30.80.8
Locomotion distance, session 11.82.34.52.1-2.12.1-2.10.90.50.81.70.61.20.81.61.6
Locomotion velocity, session 20.40.52.80.9-0.90.8-0.80.3-0.5-0.00.41.70.30.00.30.4
Locomotion distance, session 20.91.32.31.0-1.01.0-1.0-0.0-0.41.11.41.51.31.11.51.3
Locomotion velocity, session 31.31.52.31.5-1.51.5-1.50.30.41.21.50.21.21.21.31.4
Locomotion distance, session 32.12.25.22.3-2.32.3-2.31.20.30.51.50.50.60.51.41.4
Stereotopy head waving bouts, day 30.40.51.10.3-0.30.3-0.3-0.5-0.61.00.91.00.91.00.90.5
Stereotopy head waving duration, day 30.60.71.30.5-0.50.5-0.5-0.30.91.11.2-0.31.01.11.00.8
Locomotion velocity, session 70.91.02.51.0-1.01.0-1.10.20.80.91.3-0.01.00.91.61.2
Locomotion distance, session 70.40.51.30.8-0.80.8-0.80.30.60.50.8-0.40.50.51.20.9
Stereotopy head waving bouts, day 70.30.30.90.7-0.70.7-0.60.5-0.9-0.5-0.10.1-0.3-0.5-0.1-0.3
Stereotopy head waving duration, day 70.10.10.40.3-0.30.3-0.30.1-0.6-0.10.10.20.0-0.10.0-0.2
Locomotion velocity, session 84.55.410.73.2-3.23.3-3.32.12.60.52.2-0.21.00.52.22.4
Locomotion distance, session 83.44.99.53.1-3.13.1-3.11.51.21.02.50.71.41.02.42.2
Degree of sensitization distance0.80.92.3-1.51.5-1.51.5-0.80.2-0.1-0.7-0.5-0.3-0.1-0.5-0.6
Degree of sensitization stereotypy0.10.10.90.1-0.10.1-0.00.0-1.0-0.4-0.20.2-0.1-0.4-0.2-0.2
Conditioned locomotion0.60.64.50.1-0.10.1-0.20.32.1-0.10.3-1.9-0.1-0.10.00.3
Cocaine response after cond. corrected0.10.20.4-0.60.6-0.60.5-0.5-0.60.1-0.2-0.50.10.1-0.2-0.3
Cocaine response after cond. not corrected0.30.30.8-0.10.1-0.10.10.4-0.2-0.7-0.6-0.9-0.6-0.7-0.7-0.8
Cocaine response before conditioning1.21.42.90.8-0.80.8-0.81.71.1-1.6-1.0-0.9-1.5-1.7-1.0-1.1
Saline control response0.30.40.90.9-0.90.9-0.90.90.2-0.70.1-0.7-0.1-0.6-0.00.1
Bone: connectivity density1.62.56.22.0-2.02.1-2.12.22.5-1.00.3-1.5-0.7-0.90.20.3
Bone: cortical apparent density0.40.61.30.9-0.90.9-0.80.1-0.90.60.71.10.50.50.70.6
Bone: cortical area0.71.12.41.1-1.01.1-1.11.40.8-1.1-0.6-1.6-1.0-1.1-0.3-0.6
Bone: cortical porosity0.20.20.80.1-0.10.2-0.20.10.80.30.4-0.90.30.30.40.5
Bone: cortical porosity0.20.21.7-0.20.2-0.10.10.20.9-0.1-0.1-1.3-0.2-0.1-0.2-0.1
Bone: cortical thickness2.03.37.62.4-2.42.4-2.42.81.2-1.6-0.2-1.8-1.4-1.6-0.1-0.3
Bone: cortical thickness0.70.81.80.2-0.20.2-0.10.9-0.5-1.4-1.1-1.2-1.2-1.3-1.0-1.0
Bone: cortical tissue density0.40.51.60.8-0.80.8-0.70.0-1.00.60.71.30.50.50.60.6
Condit. Reinf. active minus inactive responses0.60.61.9-0.80.8-0.90.9-1.0-1.40.4-0.31.20.20.4-0.3-0.5
Condit. Reinf. active-inactive response ratio0.70.82.6-1.01.0-1.11.1-1.0-1.60.2-0.51.2-0.00.3-0.3-0.7
Condit. Reinf. active responses0.20.31.4-0.20.2-0.20.2-0.6-1.10.50.11.20.40.50.10.0
Condit. Reinf. inactive responses0.10.20.40.6-0.60.6-0.60.50.2-0.00.2-0.10.1-0.1-0.00.4
Incentive salience index mean0.10.10.40.0-0.10.0-0.0-0.3-0.30.50.30.70.40.50.30.2
Condit. Reinf. lever presses0.20.30.80.7-0.70.7-0.70.70.9-0.30.2-0.7-0.1-0.30.10.2
Condit. Reinf. active minus inactive responses0.30.41.10.8-0.80.8-0.70.4-1.1-0.20.10.90.0-0.10.10.3
Condit. Reinf. active-inactive response ratio1.01.12.3-0.90.9-0.90.9-0.0-0.9-1.1-1.5-0.3-1.2-1.1-1.5-1.5
Condit. Reinf. active responses0.60.82.50.8-0.80.7-0.7-0.2-1.60.60.71.60.90.70.81.0
Condit. Reinf. inactive responses0.91.12.10.9-0.90.9-0.9-0.1-0.71.01.21.31.31.11.31.5
Condit. Reinf. lever presses0.40.51.3-0.60.6-0.60.6-1.1-0.10.90.50.61.01.00.40.6
Condit. Reinf. lever reinforcers received0.70.92.60.9-0.90.9-0.8-0.1-1.30.70.81.60.90.80.91.1
Conditioned reinforcement - actives0.20.30.80.1-0.10.0-0.0-0.6-0.90.70.60.80.70.60.50.6
Conditioned reinforcement - inactives0.20.31.5-0.60.6-0.50.5-0.30.5-0.1-0.7-0.80.1-0.1-1.2-0.1
Conditioned locomotion1.41.84.8-1.41.4-1.41.4-2.2-1.31.60.40.91.61.50.20.9
Patch foraging indifference point 0 sec0.40.71.51.0-1.01.0-0.90.20.50.70.80.31.00.80.61.2
Patch foraging indifference point AUC0.30.52.6-0.10.10.0-0.1-0.31.60.60.6-1.10.70.50.70.6
Delay disc. indifference point, 0s delay0.20.30.50.4-0.40.3-0.3-0.1-0.60.40.70.70.60.40.70.6
Delay disc. indifference point, 16s delay0.50.61.20.7-0.70.7-0.70.30.30.81.00.90.90.71.10.6
Delay disc. indifference point, 2s delay0.60.71.70.0-0.10.1-0.1-0.70.31.21.20.41.31.21.30.9
Delay disc. indifference point, 24s delay1.61.84.1-0.40.4-0.30.3-1.6-0.42.01.61.61.92.01.60.9
Delay disc. indifference point, 4s delay2.42.55.11.3-1.31.3-1.3-0.3-0.21.92.21.31.82.02.31.8
Delay disc. indifference point, 8s delay0.30.31.00.7-0.70.7-0.70.4-0.30.30.70.60.20.31.0-0.1
Indifference point function ln k0.30.52.80.1-0.1-0.00.10.4-1.7-0.8-0.60.9-0.7-0.7-0.6-0.5
Indifference point function log k0.30.52.80.1-0.1-0.00.10.4-1.7-0.8-0.60.9-0.7-0.7-0.6-0.5
Patch foraging total patch changes 0 sec0.40.71.50.9-0.90.9-0.90.20.50.80.90.11.10.80.61.2
Patch foraging total patch changes 12 sec0.81.02.30.8-0.90.9-0.90.00.71.01.30.51.21.01.51.5
Patch foraging total patch changes 18 sec0.00.00.1-0.20.2-0.20.2-0.3-0.00.3-0.30.30.20.2-0.20.1
Patch foraging total patch changes 24 sec1.32.16.11.2-1.21.3-1.3-0.20.61.51.70.92.01.51.72.5
Patch foraging total patch changes 6 sec1.21.83.61.1-1.11.2-1.2-0.01.61.51.7-0.21.71.41.61.9
Patch foraging time to switch 0 sec0.20.51.40.2-0.20.1-0.10.7-0.4-1.0-0.90.4-1.2-1.0-0.5-1.1
Patch foraging water rate 0 sec0.20.40.8-0.60.5-0.50.5-0.70.50.80.3-0.80.90.8-0.00.7
Patch foraging water rate 12 sec0.40.91.80.6-0.60.7-0.7-0.11.21.11.2-0.61.21.11.01.3
Patch foraging water rate 18 sec0.30.51.3-0.10.1-0.10.1-0.8-0.70.70.61.01.00.80.41.1
Patch foraging water rate 24 sec0.50.72.1-1.01.0-1.01.0-1.1-1.50.2-0.30.60.30.3-0.8-0.2
Patch foraging water rate 6 sec0.81.12.7-0.40.4-0.40.3-1.30.11.61.10.81.61.51.11.3
Seeking ratio, delayed vs. immediate footshock0.40.51.3-0.00.0-0.0-0.0-0.6-0.11.20.90.81.11.10.70.9
Distance traveled before self-admin0.70.91.8-1.21.2-1.21.2-1.3-1.00.80.30.60.90.90.6-0.0
Distance traveled after self-admin3.03.710.7-1.31.3-1.31.3-2.6-3.32.21.22.62.12.11.31.1
Extensor digitorum longus weight4.517.644.04.8-4.74.7-4.66.63.0-5.0-1.3-3.7-4.3-5.0-1.5-1.2
Bone: elastic displacement1.31.53.31.1-1.11.1-1.11.80.6-1.7-0.8-1.2-1.6-1.7-0.5-0.5
Bone: elastic work1.72.35.11.2-1.21.2-1.12.10.4-2.3-1.2-1.4-2.0-2.2-0.9-0.9
Bone: endosteal estimation1.12.44.9-2.22.2-2.22.2-2.1-2.00.4-0.91.00.20.4-0.8-0.9
Bone: endosteal perimeter0.51.22.5-1.61.6-1.51.5-1.0-0.5-0.3-1.1-0.4-0.4-0.2-0.9-1.3
Epididymis fat weight0.31.13.3-0.70.7-0.70.7-1.1-0.91.30.81.81.31.21.20.7
Delta time in closed arm before/after self-admin0.30.20.80.5-0.50.5-0.50.30.90.00.70.2-0.1-0.10.60.3
Delta time in open arm before/after self-admin0.20.20.6-0.60.6-0.60.6-0.20.70.30.4-0.10.20.30.3-0.3
Diff in mean of infusions in LGA sessions1.51.83.3-1.11.1-1.21.2-0.0-1.8-1.4-1.8-0.0-1.7-1.4-1.5-1.6
Delay discount exponential model param1.21.33.5-0.60.6-0.60.60.40.1-1.5-1.7-1.2-1.5-1.6-1.9-1.0
Extinction: sum of active levers before priming0.40.51.6-0.50.4-0.40.4-0.91.00.80.20.30.80.70.31.3
Active lever presses in extinction session 61.21.22.8-1.61.5-1.51.5-1.7-0.90.6-0.01.00.60.8-0.40.0
Bone: final force0.20.40.8-0.70.7-0.70.7-0.2-0.1-0.3-0.8-0.4-0.6-0.3-0.7-0.9
Bone: final moment0.30.50.9-0.90.9-0.90.9-0.6-0.6-0.1-0.7-0.1-0.3-0.1-0.7-0.9
Food consumed during 24 hour testing period0.20.30.70.7-0.70.8-0.80.80.6-0.50.2-0.6-0.2-0.40.40.1
Glucose0.81.33.3-0.90.9-0.90.9-1.6-1.81.30.51.51.11.20.60.4
Heart weight0.50.81.6-0.30.3-0.30.30.81.0-1.1-1.3-0.8-1.1-1.1-1.1-0.9
Delay discount hyperbolic model param1.41.54.1-0.70.8-0.80.80.3-0.2-1.6-1.9-1.0-1.6-1.6-2.0-1.1
Intermittent access intake day 1-15 change0.30.73.4-0.50.4-0.50.5-0.7-1.80.50.01.60.50.6-0.70.0
Intermittent access intake escalation0.30.63.6-0.30.3-0.40.4-0.5-1.90.4-0.01.50.30.5-0.7-0.1
Intermittent access intake escalation 20.91.02.0-0.80.8-0.80.8-1.4-1.11.30.31.21.21.2-0.21.0
Intermitt. access day 1 inactive lever presses0.52.04.62.1-2.12.1-2.11.21.20.31.0-0.20.80.40.71.6
Intermitt. access day 15 inactive lever presses0.40.82.1-0.70.7-0.70.70.21.0-0.9-1.3-1.5-0.8-0.7-1.4-0.7
Intermitt. access escalation Index1.42.03.1-1.71.7-1.71.7-0.6-1.5-1.4-1.70.4-1.5-1.3-1.3-1.3
Intermittent access day 1 total infusions0.20.30.8-0.90.9-0.90.8-0.80.20.4-0.1-0.30.20.1-0.30.1
Intermittent access day 15 total infusions0.50.81.7-0.80.8-0.80.8-1.3-1.11.20.50.91.11.0-0.10.6
Intermittent access terminal intake (last 3 days)1.11.43.4-1.21.1-1.11.1-1.8-0.51.70.80.61.61.40.11.2
Intermittent access total infusions0.50.61.3-0.90.9-0.90.8-1.1-0.11.10.4-0.10.80.7-0.30.6
Intermittent access day 1 locomotion0.20.20.6-0.70.7-0.60.6-0.7-0.50.3-0.2-0.10.40.2-0.60.1
Intermittent access day 15 total locomotion1.32.46.6-0.10.0-0.00.0-1.4-0.32.51.61.52.62.51.31.8
Intermittent access total locomotion1.01.22.6-1.41.4-1.41.4-1.6-1.11.00.20.71.10.9-0.50.5
Intermittent access standard deviation0.30.72.00.5-0.50.6-0.6-0.20.51.41.1-0.01.41.20.21.1
Left kidney weight0.20.92.3-0.60.7-0.60.60.20.8-1.0-1.4-1.5-0.8-1.0-1.4-0.9
Right kidney weight0.62.55.2-2.32.3-2.22.2-1.20.8-0.4-1.8-1.2-0.6-0.4-2.0-1.4
Cocaine induced anxiety2.94.26.9-1.91.9-2.02.0-0.2-2.2-2.2-2.6-0.4-2.3-2.1-2.5-2.6
Post-drug Anxiety2.02.14.7-0.90.9-1.01.00.4-1.7-2.0-1.7-0.1-1.9-1.9-1.5-2.2
Baseline Anxiety1.51.74.71.4-1.41.4-1.40.4-0.10.91.91.11.21.22.21.2
Tail length2.07.816.7-4.14.0-4.04.0-4.1-3.11.6-0.91.41.21.6-0.8-0.7
Length with tail3.113.529.5-5.45.4-5.45.4-5.0-3.71.2-2.12.20.71.2-2.0-1.8
Length without tail0.92.85.4-2.32.3-2.32.3-2.2-1.80.4-1.21.60.00.4-1.3-0.9
Times rat made contact with spout0.80.97.40.0-0.00.1-0.10.82.7-0.5-0.0-1.8-0.3-0.5-0.20.0
Lifetime Intake0.40.51.0-0.90.9-0.80.8-1.00.10.90.3-0.70.60.5-0.40.4
Liver weight, left0.50.92.1-0.50.5-0.40.4-1.2-0.01.31.00.31.41.30.81.4
Liver weight, right1.11.94.50.3-0.30.3-0.4-1.0-0.11.81.90.72.01.81.92.1
Locomotor activity0.20.31.00.1-0.10.1-0.1-0.5-0.10.80.90.61.00.70.60.6
Locomotor testing distance0.40.71.40.9-0.90.9-0.90.1-0.11.01.20.91.00.90.80.7
Locomotor testing rearing0.40.71.21.1-1.11.1-1.10.2-0.30.91.00.70.90.90.60.7
Locomotion in novel chamber1.01.23.40.1-0.20.1-0.1-0.8-0.81.71.41.91.31.51.30.8
Locomotion in novel chamber post-restriction0.30.51.4-0.30.3-0.30.3-0.80.81.10.70.51.01.20.40.3
Fecal boli incidents, locomotor time 10.30.42.3-0.40.4-0.40.30.3-0.3-0.6-0.2-1.1-0.9-0.6-0.3-1.5
Change in fecal boli incidents, locomotor task0.80.81.7-1.11.1-1.11.1-0.8-1.3-0.3-1.20.2-0.5-0.3-1.0-0.7
Time >=10cm from walls, locomotor time 11.31.42.5-0.91.0-0.91.0-0.4-1.5-1.2-1.4-1.2-1.1-1.1-1.4-1.6
Bouts of movement, locomotor time 10.20.20.5-0.50.5-0.50.5-0.7-0.40.60.10.20.30.50.30.3
Total resting periods, locomotor time 10.30.40.8-0.80.8-0.80.8-0.9-0.70.50.10.30.30.50.40.3
Rest time, locomotor task time 10.50.71.5-1.21.2-1.21.2-0.9-1.1-0.1-0.60.2-0.3-0.1-0.4-0.2
Distance moved, locomotor task time 10.10.21.10.3-0.30.3-0.30.50.9-0.10.1-1.0-0.1-0.2-0.30.2
Vertical activity count, locomotor time 10.20.51.3-0.30.2-0.30.3-0.8-0.01.20.81.01.11.00.50.6
Time >=10cm from walls, locomotor time 20.50.81.6-0.10.1-0.10.10.5-0.5-1.1-1.1-1.1-1.1-1.1-1.3-1.3
Bouts of movement, locomotor time 21.01.53.20.2-0.20.2-0.2-1.0-0.01.61.51.71.61.81.81.4
Total resting periods, locomotor time 20.61.12.20.0-0.10.0-0.1-0.80.11.41.21.51.31.51.51.3
Rest time, locomotor task time 20.40.61.0-0.60.6-0.50.5-1.00.71.00.7-0.70.81.00.60.7
Distance moved, locomotor task time 20.60.71.70.5-0.50.4-0.41.2-0.0-1.2-0.8-0.1-1.0-1.3-1.1-0.4
Vertical activity count, locomotor time 20.30.43.1-0.00.0-0.10.2-0.2-1.4-0.0-0.21.70.1-0.2-0.40.0
Light reinforcement 10.30.63.00.3-0.30.4-0.4-0.31.70.90.9-0.21.11.00.40.9
Light reinforcement 21.21.89.50.9-0.91.1-1.10.43.10.81.3-1.71.11.01.01.1
Bone: marrow area1.02.24.4-2.12.1-2.12.1-1.9-1.90.4-0.91.00.20.4-0.7-0.8
Bone: maximum diameter0.51.02.1-0.50.5-0.50.50.40.1-1.3-1.4-1.1-1.3-1.2-1.3-1.4
Bone: maximum force0.20.31.2-0.40.4-0.30.30.00.5-0.4-0.6-1.1-0.6-0.4-0.5-0.7
Bone: maximum moment0.20.30.7-0.60.7-0.60.6-0.40.0-0.2-0.6-0.8-0.3-0.2-0.5-0.7
Mean time between licks in bursts0.51.32.8-1.71.7-1.71.7-1.3-1.30.2-0.80.7-0.20.2-0.8-0.7
Mean num. licks in bursts1.01.69.21.0-1.01.0-1.11.33.0-0.40.5-2.1-0.1-0.40.10.3
Cd content in liver2.83.16.7-0.40.4-0.50.51.5-0.8-2.6-2.3-1.3-2.6-2.6-2.3-2.3
Co content in liver0.60.72.6-0.80.8-0.80.8-0.7-1.60.1-0.71.1-0.20.1-0.7-1.1
Cu content in liver0.10.10.60.2-0.20.3-0.3-0.10.30.20.4-0.70.40.20.30.5
Fe content in liver0.50.61.6-0.40.5-0.40.5-0.10.1-0.7-1.1-0.8-0.9-0.7-1.3-1.2
K content in liver1.91.83.51.3-1.31.3-1.40.21.51.41.8-0.01.41.31.91.3
Mg content in liver0.30.31.20.2-0.20.3-0.3-0.11.10.60.6-0.80.50.60.90.1
Mn content in liver1.01.12.61.5-1.51.5-1.51.6-0.2-0.80.3-0.3-0.5-0.80.4-0.6
Na content in liver3.23.56.81.5-1.51.6-1.70.12.61.72.5-0.22.01.72.62.3
Rb content in liver0.91.03.1-1.11.1-1.21.2-0.7-1.8-0.5-1.00.7-0.7-0.5-0.9-1.0
Se content in liver0.81.02.40.6-0.60.6-0.6-0.21.51.21.30.31.41.21.30.8
Sr content in liver1.31.22.50.2-0.20.2-0.21.20.5-1.6-1.1-1.3-1.5-1.6-1.4-1.2
Zn content in liver0.30.30.70.8-0.80.9-0.90.60.60.20.5-0.40.20.10.50.1
Bone: minimum diameter2.03.68.8-2.82.8-2.72.7-3.0-1.61.2-0.60.51.11.3-0.2-0.6
Time in familiar zone, hab. session 12.12.03.71.9-1.91.9-1.91.21.70.41.4-1.10.50.31.51.2
Time in novel zone, hab. session 14.44.49.7-3.13.1-3.13.1-2.4-2.20.2-1.51.5-0.10.2-1.7-1.2
Total zone transitions, hab. session 12.53.56.21.5-1.51.5-1.5-0.40.52.12.41.82.42.22.52.5
Total locomotion distance, hab. session 12.73.87.71.4-1.41.5-1.5-0.21.82.32.8-0.02.42.32.72.7
Locomotion velocity, hab. session 13.04.27.91.9-2.02.0-2.10.42.02.02.8-0.22.12.02.72.6
Time in familiar zone, hab. session 20.70.74.80.0-0.00.1-0.20.32.10.00.2-2.2-0.0-0.00.1-0.1
Time in novel zone, hab. session 21.21.36.7-0.70.7-0.80.9-0.7-2.6-0.1-0.72.4-0.1-0.1-0.5-0.2
Total zone transitions, hab. session 20.10.20.50.4-0.50.4-0.40.2-0.10.20.40.70.40.20.50.5
Total locomotion distance, hab. session 20.30.30.80.4-0.40.4-0.40.00.60.70.90.20.70.70.80.8
Locomotion velocity, hab. session 20.70.92.00.8-0.80.8-0.80.10.81.01.40.21.11.01.41.2
Novel to familiar place preference ratio0.30.30.60.2-0.20.2-0.2-0.30.70.70.7-0.20.70.70.60.7
Novelty place preference0.30.30.7-0.00.00.0-0.0-0.50.70.80.7-0.30.80.80.60.8
Time in novel zone, NPP test0.40.51.1-0.10.1-0.10.1-0.70.51.00.80.11.01.00.70.9
Total zone transitions, NPP test0.50.82.01.4-1.41.4-1.31.2-0.4-0.50.20.4-0.3-0.40.20.1
Total locomotion distance, NPP test0.91.22.21.4-1.41.5-1.50.81.30.51.2-0.90.60.61.01.0
Locomotion velocity, NPP test1.01.32.91.7-1.71.7-1.71.11.20.21.0-0.90.30.20.80.8
Intraocular pressure1.01.53.8-1.91.9-1.91.9-1.4-0.30.1-0.90.30.10.1-0.9-0.2
Delta distance traveled before/after self-admin1.41.46.90.1-0.10.00.0-1.0-2.61.30.82.21.01.10.90.7
Delta ambulatory time before/after self-admin1.01.28.70.1-0.10.1-0.0-0.7-3.00.80.42.20.50.50.70.4
Parametrial fat weight0.30.81.6-1.11.1-1.11.1-1.3-0.41.0-0.30.40.81.1-0.6-0.1
Pavlov. Cond. lever latency0.60.81.5-0.60.6-0.60.60.20.1-0.9-1.2-1.2-1.1-1.0-1.1-1.2
Pavlov. Cond. magazine entry latency0.40.51.20.8-0.80.8-0.80.30.60.51.00.80.70.51.10.7
Pavlov. Cond. change in total contacts0.40.41.60.5-0.50.4-0.4-0.1-0.60.50.71.30.60.50.70.6
Pavlov. Cond. index score1.01.32.41.2-1.21.2-1.20.30.30.91.51.21.20.91.51.4
Pavlov. Cond. latency score0.70.91.51.1-1.11.1-1.10.40.30.71.20.90.90.71.21.1
Pavlov. Cond. lever contacts0.60.81.90.9-0.90.8-0.80.1-0.40.71.11.40.80.71.01.1
Pavlov. Cond. magazine entry number0.60.82.2-0.80.8-0.80.8-0.10.1-0.7-1.1-1.5-0.9-0.7-1.2-0.9
Pavlov. Cond. intertrial magazine entries0.60.71.50.8-0.80.8-0.8-0.2-0.40.91.20.61.00.91.11.2
Pavlov. Cond. lever-magazine prob. diff.1.11.42.51.2-1.21.2-1.20.30.30.91.51.31.20.91.61.4
Pavlov. Cond. response bias0.91.12.40.7-0.80.7-0.7-0.2-0.11.11.41.61.31.11.51.3
Pavlov. Cond. lever latency0.20.32.80.2-0.20.2-0.1-0.0-1.7-0.1-0.20.9-0.2-0.1-0.20.0
Pavlov. Cond. magazine entry latency0.80.92.0-1.41.4-1.41.4-0.60.1-0.3-1.0-0.4-0.5-0.3-1.0-1.0
Pavlov. Cond. change in total contacts0.20.32.20.2-0.20.3-0.30.31.50.10.4-0.90.30.10.40.3
Pavlov. Cond. index score0.50.61.1-1.11.1-1.01.0-0.31.0-0.3-0.7-0.9-0.3-0.3-0.7-0.8
Pavlov. Cond. latency score0.50.71.5-0.80.8-0.80.80.11.1-0.7-0.9-1.2-0.7-0.7-0.9-0.9
Pavlov. Cond. lever contacts0.30.42.2-0.60.6-0.50.5-0.51.50.30.2-0.80.50.40.2-0.1
Pavlov. Cond. magazine entry number0.60.71.21.0-1.01.0-1.00.2-0.30.61.10.50.70.61.11.1
Pavlov. Cond. intertrial magazine entries0.10.10.40.1-0.10.1-0.1-0.2-0.70.30.30.50.40.30.30.2
Pavlov. Cond. lever-magazine prob. diff.0.50.71.2-1.11.1-1.11.1-0.41.1-0.3-0.7-0.8-0.3-0.3-0.7-0.8
Pavlov. Cond. response bias0.30.40.9-0.90.9-0.90.9-0.80.80.50.0-0.00.50.60.1-0.2
Time in closed arm before self-admin0.50.62.9-0.50.5-0.50.50.1-0.5-0.9-1.30.3-0.7-0.6-1.7-0.5
Time in closed arm after self-admin0.40.51.11.1-1.11.1-1.00.80.4-0.40.50.5-0.1-0.20.10.5
Time in open arm before self-admin0.20.21.0-0.30.3-0.30.3-0.7-1.00.10.00.3-0.0-0.00.5-0.2
Time in open arm after self-admin0.91.01.9-1.21.2-1.21.1-1.40.41.20.80.21.01.21.00.1
Bone: periosteal estimation0.30.61.2-0.90.9-0.90.9-0.6-1.0-0.5-1.1-0.1-0.5-0.4-0.8-1.0
Bone: periosteal perimeter0.10.21.10.1-0.00.1-0.10.20.7-0.4-0.4-1.1-0.4-0.4-0.2-0.5
Bone: post-yield work0.91.43.3-1.81.8-1.71.7-1.40.60.4-0.5-1.30.20.4-0.7-0.7
Progressive ratio test 1 active lever presses1.41.74.3-1.81.8-1.71.7-2.10.51.60.3-0.31.31.1-0.10.5
Progressive ratio test 1 breakpoint1.31.64.1-1.71.7-1.61.6-2.00.51.60.3-0.31.31.2-0.10.5
Progressive ratio test 1 inactive lever presses0.30.42.60.3-0.30.4-0.40.31.10.2-0.0-1.60.40.2-0.40.5
Progressive ratio test 2 active lever presses0.91.12.7-1.31.3-1.21.2-1.60.31.30.3-0.51.31.00.00.8
Progressive ratio test 2 breakpoint0.91.12.6-1.31.2-1.21.1-1.60.31.30.3-0.51.31.00.10.7
Progressive ratio test 2 inactive lever presses0.30.50.8-0.70.7-0.70.6-0.80.50.8-0.0-0.90.90.7-0.50.6
Incentive Sensitization - Responses0.50.71.6-1.31.3-1.31.3-1.2-0.90.1-0.50.40.40.1-0.50.1
Incentive Sensitization - Breakpoint0.60.81.7-1.31.3-1.31.3-1.2-0.90.1-0.50.40.40.1-0.50.1
Sum of active levers in priming session hrs 5-60.40.41.70.4-0.40.5-0.50.21.00.40.6-1.30.70.30.50.5
Progressive ratio0.10.20.60.4-0.40.4-0.40.40.4-0.60.1-0.8-0.4-0.6-0.10.3
Food seeking constrained by brief footshock0.20.31.20.3-0.30.3-0.30.50.3-0.7-0.70.3-0.5-0.6-1.10.3
Seeking ratio, punishment vs. effort0.10.10.2-0.20.2-0.20.2-0.20.30.4-0.20.50.40.4-0.10.3
Retroperitoneal fat weight0.41.93.3-1.71.7-1.81.8-1.7-1.80.5-0.71.80.40.5-1.0-0.4
Reaction time number correct0.40.71.5-1.21.2-1.21.2-0.7-1.0-0.3-0.70.8-0.3-0.2-0.6-0.8
Reaction time mean minus median0.41.12.1-1.51.5-1.41.4-0.80.2-0.5-1.3-1.0-0.5-0.6-1.0-0.5
Reaction time mean minus median AUC0.61.52.7-1.71.7-1.61.6-0.60.3-0.8-1.7-1.3-0.7-0.9-1.2-0.5
Reaction time num false alarms1.01.42.81.0-1.01.0-1.00.0-0.11.31.61.01.41.41.71.5
Reaction time num false alarms AUC0.91.52.81.0-1.01.0-1.0-0.0-0.11.31.61.21.51.41.71.6
Reaction time trials correct on left0.40.71.5-1.21.2-1.21.2-0.7-1.0-0.3-0.70.8-0.3-0.2-0.6-0.8
Reaction time trials on left0.40.81.5-1.21.2-1.21.2-0.7-1.1-0.3-0.80.8-0.4-0.2-0.7-0.9
Reaction time mean1.01.62.8-1.61.6-1.61.6-0.7-1.2-0.8-1.7-0.5-1.0-0.9-1.3-1.3
Reaction time mean AUC0.81.32.4-1.51.5-1.51.5-0.9-1.2-0.4-1.4-0.2-0.6-0.6-1.0-1.1
Median of all reaction times1.01.42.2-1.41.4-1.51.5-0.6-1.5-0.7-1.5-0.1-1.1-0.8-1.1-1.5
Reaction time omissions0.91.33.3-0.30.4-0.40.40.6-1.0-1.8-1.8-0.6-1.4-1.7-1.5-1.2
Reaction time false alarm rate1.41.93.61.2-1.31.2-1.30.10.41.51.90.81.61.51.91.8
Reaction time premature initiation rate0.40.51.40.7-0.70.7-0.70.10.70.80.90.21.20.80.70.6
Reaction time premature initiations0.10.21.00.1-0.10.1-0.1-0.20.30.60.40.61.00.60.30.3
Std. dev. reaction times0.51.01.9-1.31.3-1.31.3-0.8-0.7-0.5-1.4-0.5-0.5-0.6-1.0-0.6
Reaction time trials completed0.40.81.5-1.21.2-1.21.2-0.7-1.1-0.3-0.80.8-0.4-0.2-0.7-0.9
Reaction time trials AUC0.61.12.0-1.41.4-1.41.4-0.8-1.3-0.4-1.00.9-0.5-0.3-0.9-1.0
Run reversals in cocaine runway, females0.30.30.90.6-0.60.6-0.60.1-0.20.60.30.20.40.50.20.9
Run reversals in cocaine runway, males1.21.22.9-0.30.3-0.30.30.90.3-1.7-1.6-0.5-1.6-1.7-1.5-1.2
Latency to leave start box in cocaine runway0.70.82.2-1.01.0-1.01.0-1.5-0.21.00.61.20.91.00.50.3
Latency to leave start box in cocaine runway, F0.91.12.3-0.40.4-0.40.3-1.40.31.51.20.81.51.51.11.1
Latency to leave start box in cocaine runway, M1.11.01.8-1.31.3-1.31.3-0.7-1.1-0.4-0.90.9-0.7-0.4-0.8-1.1
Std. dev. time between licks in bursts0.20.30.7-0.50.5-0.50.5-0.8-0.90.60.30.00.50.60.40.1
Total sessions with >9 infusions0.30.41.6-0.70.7-0.60.6-0.80.50.60.1-1.30.40.3-0.40.1
Short access day 1 total inactive lever presses0.30.40.9-0.20.1-0.10.1-0.60.20.80.80.01.00.90.80.9
Short access day 10 total inactive lever presses0.51.23.21.7-1.71.7-1.61.80.4-0.8-0.2-0.4-0.6-0.6-0.30.1
Short access day 1 total infusions1.01.33.40.3-0.30.4-0.4-0.71.31.81.5-0.81.51.41.51.4
Short access day 10 total infusions0.81.02.10.3-0.30.4-0.4-0.61.01.41.1-1.31.41.10.71.4
Short access total infusions0.20.32.1-0.40.4-0.30.3-0.40.60.40.1-1.40.30.0-0.30.3
Short access day 1 locomotion1.31.64.3-0.70.7-0.60.6-1.8-0.92.11.30.51.71.81.11.3
Short access day 10 total locomotion0.30.51.30.4-0.40.4-0.4-0.4-0.11.00.9-0.41.11.00.70.8
Short access total locomotion0.40.51.3-0.40.4-0.30.3-1.1-0.31.00.5-0.71.10.90.00.8
One hour access (0.3 mA shock)2.02.35.2-1.91.9-1.91.9-2.3-1.61.70.21.31.21.4-0.20.4
Compulsive drug intake1.11.33.11.6-1.61.6-1.51.80.5-1.2-0.4-0.3-1.0-1.1-0.1-0.2
One hour access (shock baseline)1.72.76.4-1.71.6-1.61.5-2.5-0.62.51.00.72.02.20.51.0
Social response proportion0.20.21.4-0.60.6-0.60.6-0.20.2-0.3-0.4-1.2-0.2-0.2-0.2-0.1
Social responses0.70.92.9-0.10.1-0.10.1-1.0-0.91.00.91.71.21.20.91.1
Social time0.20.30.5-0.70.7-0.70.7-0.5-0.6-0.2-0.40.40.1-0.3-0.5-0.0
Soleus weight2.67.518.24.3-4.34.2-4.23.61.5-1.01.7-0.4-0.4-1.01.71.7
Bone: stiffness0.71.23.10.2-0.20.3-0.3-0.90.81.81.50.11.61.71.31.2
Tibialis anterior weight1.86.214.03.5-3.43.4-3.43.72.5-1.90.7-1.8-1.3-1.80.40.7
Time to tail flick, vehicle, before self-admin1.11.12.5-1.61.5-1.61.6-1.4-1.00.40.11.10.30.40.0-0.2
Time to tail flick, vehicle, after self-admin0.50.62.80.4-0.40.4-0.3-0.5-0.80.50.81.70.90.71.01.0
Time to tail flick, test, before self-admin0.40.41.4-0.30.3-0.30.30.2-0.3-0.8-0.50.6-0.8-0.7-1.2-0.8
Time to tail flick, test, after self-admin1.21.33.4-1.51.5-1.51.5-1.8-1.20.3-0.11.30.40.4-0.10.0
Delta time to tail flick, vehicle, before/after SA0.50.51.31.1-1.11.1-1.10.60.5-0.10.40.20.40.00.20.9
Delta time to tail flick, test, before/after SA0.50.51.3-0.50.5-0.50.4-1.2-0.20.80.60.10.90.81.10.7
Tibia length1.33.59.3-2.32.3-2.32.3-1.4-3.1-0.8-2.00.4-0.9-0.7-1.8-2.0
Ambulatory time before self-admin0.40.71.5-0.60.6-0.60.6-1.1-0.51.00.80.51.21.10.80.4
Ambulatory time after self-admin2.83.39.7-0.80.8-0.90.9-2.1-3.12.11.32.92.11.91.41.2
Bone: tissue strength0.30.30.6-0.10.1-0.00.0-0.60.80.80.6-0.10.60.80.60.6
Total heroin consumption2.12.49.0-1.71.7-1.71.8-2.0-3.00.3-0.22.60.40.40.2-0.2
Bone: trabecular number1.01.63.51.9-1.81.9-1.91.61.6-0.40.6-1.1-0.3-0.40.40.7
Bone: trabecular spacing0.10.10.50.1-0.10.1-0.1-0.1-0.70.40.50.20.40.40.50.2
Bone: trabecular thickness0.40.51.21.1-1.11.1-1.10.91.0-0.50.1-0.4-0.3-0.40.10.3
Bone: trabecular tissue density0.10.10.30.4-0.40.4-0.4-0.2-0.50.20.20.20.20.2-0.20.2
Water consumed over 24 hours0.10.10.7-0.30.3-0.30.20.10.8-0.2-0.1-0.8-0.0-0.2-0.1-0.1
Number of responses in last shaping day2.02.26.70.9-1.01.0-1.0-0.30.42.12.60.51.71.92.21.5