Hub : Genes

Afp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS NM_012493.2 0.05 0.03 9.9e-06 0.03 0.03 0 0.03 6.4e-04 1.1e-04 7.6e-02 4.3e-04
2 Adipose alternative TSS XM_039091614.2 0.05 0.03 9.0e-06 0.03 0.03 0 0.03 6.8e-04 1.1e-04 7.5e-02 3.2e-04
3 Adipose isoform ratio NM_012493.2 0.06 0.04 1.3e-05 0.02 0.03 0.01 0.02 9.8e-04 2.4e-04 6.2e-02 1.0e-03
4 Adipose isoform ratio XM_039091614.2 0.06 0.04 1.6e-05 0.02 0.03 0 0.02 1.9e-03 4.3e-04 9.8e-02 1.8e-03
5 Adipose gene expression Afp 0.69 0.08 0.0e+00 0.48 0.55 0.56 0.56 1.1e-60 1.7e-73 1.7e-75 2.5e-75
6 Liver gene expression Afp 0.41 0.19 2.1e-04 0 0.02 0.04 0.01 1.9e-01 8.7e-04 1.7e-05 1.3e-02
7 Brain gene expression Afp 0.13 0.09 4.5e-07 0.08 0.08 0.07 0.08 9.2e-08 1.5e-07 2.1e-07 8.6e-08
8 IC gene expression Afp 0.16 0.1 2.2e-04 0.09 0.05 0.02 0.09 1.1e-04 5.0e-03 3.8e-02 2.0e-04
9 pVTA gene expression Afp 0.21 0.1 1.6e-07 0.03 0.1 0.1 0.09 1.9e-03 2.4e-08 2.2e-08 6.8e-08
10 BLA gene expression Afp 0.07 0.04 1.7e-03 0.05 0.04 0.04 0.05 1.5e-03 2.2e-03 5.9e-03 8.0e-04
11 NAcc gene expression Afp 0.2 0.06 0.0e+00 0.24 0.22 0.23 0.24 9.7e-37 7.5e-33 1.8e-34 1.3e-35
12 PL gene expression Afp 0.29 0.11 0.0e+00 0.26 0.24 0.24 0.26 9.6e-28 7.0e-26 5.8e-26 1.0e-28
13 IL gene expression Afp 0.24 0.12 1.9e-04 0.17 0.16 0.1 0.17 6.6e-05 1.3e-04 2.3e-03 7.2e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density1.12.14.31.9-1.91.9-1.9-2.1-1.5-1.20.11.5-1.01.2-0.1-0.2
Area under the delay curve0.71.13.00.6-0.70.6-0.60.30.11.3-1.5-1.21.3-1.41.7-0.9
BMI with tail2.07.014.83.7-3.73.7-3.7-3.9-3.1-1.5-0.52.2-0.91.50.4-1.4
BMI without tail0.31.53.81.3-1.31.3-1.3-1.9-0.8-1.30.41.7-0.91.3-0.6-0.0
Body weight0.10.41.9-0.60.6-0.60.60.20.0-0.51.20.2-0.30.6-1.40.2
Weight adjusted by age0.10.41.80.1-0.10.1-0.1-0.50.5-0.50.31.0-0.90.4-0.41.3
Bone surface0.61.22.40.3-0.30.3-0.3-1.2-0.9-1.51.31.3-1.51.5-1.21.1
Bone volume0.40.71.40.9-0.90.9-0.9-1.2-0.6-1.00.60.8-0.91.0-0.50.3
Breakpoint value in progressive ratio session0.10.20.50.0-0.00.0-0.0-0.20.3-0.70.50.4-0.50.6-0.20.4
Number of licking bursts0.30.82.7-1.11.1-1.11.11.11.70.40.3-1.10.2-0.4-0.00.0
Context. condit. distance diff. score2.63.25.72.4-2.42.4-2.4-1.0-1.01.1-2.1-0.61.4-1.12.0-1.9
Locomotion velocity, session 10.70.81.71.3-1.31.3-1.2-0.50.20.3-0.7-1.00.5-0.30.8-0.8
Locomotion distance, session 11.82.34.52.1-2.12.1-2.1-0.9-0.50.8-1.7-0.61.2-0.81.6-1.6
Locomotion velocity, session 20.40.52.80.9-0.90.8-0.8-0.30.5-0.0-0.4-1.70.3-0.00.3-0.4
Locomotion distance, session 20.91.32.31.0-1.01.0-1.00.00.41.1-1.4-1.51.3-1.11.5-1.3
Locomotion velocity, session 31.31.52.31.5-1.51.5-1.5-0.3-0.41.2-1.5-0.21.2-1.21.3-1.4
Locomotion distance, session 32.02.25.22.3-2.32.3-2.3-1.2-0.30.5-1.5-0.50.6-0.51.3-1.4
Stereotopy head waving bouts, day 30.40.51.10.3-0.30.3-0.30.50.61.0-0.9-1.00.9-1.00.9-0.5
Stereotopy head waving duration, day 30.50.71.30.5-0.50.5-0.50.3-0.91.1-1.20.31.0-1.11.0-0.8
Locomotion velocity, session 70.91.02.51.0-1.01.0-1.1-0.2-0.80.9-1.30.01.0-0.91.6-1.2
Locomotion distance, session 70.40.51.30.8-0.80.8-0.8-0.3-0.60.5-0.80.40.5-0.51.2-0.9
Stereotopy head waving bouts, day 70.20.30.90.7-0.70.7-0.6-0.50.9-0.50.1-0.1-0.30.5-0.10.3
Stereotopy head waving duration, day 70.10.10.40.3-0.30.3-0.3-0.10.6-0.1-0.1-0.20.00.10.00.2
Locomotion velocity, session 84.55.410.73.2-3.23.3-3.3-2.1-2.60.5-2.20.21.0-0.52.2-2.4
Locomotion distance, session 83.44.99.53.1-3.13.1-3.1-1.5-1.21.0-2.5-0.71.4-1.02.4-2.2
Degree of sensitization distance0.80.92.3-1.51.5-1.51.50.8-0.2-0.10.70.5-0.30.1-0.50.6
Degree of sensitization stereotypy0.10.10.90.1-0.10.1-0.0-0.01.0-0.40.2-0.2-0.10.4-0.20.2
Conditioned locomotion0.50.64.40.1-0.10.1-0.2-0.3-2.1-0.1-0.31.9-0.10.10.0-0.3
Cocaine response after cond. corrected0.10.20.4-0.60.6-0.60.50.50.60.10.20.50.1-0.1-0.20.3
Cocaine response after cond. not corrected0.20.30.8-0.10.1-0.10.1-0.40.2-0.70.60.9-0.60.7-0.70.8
Cocaine response before conditioning1.21.42.90.8-0.80.8-0.8-1.7-1.1-1.61.00.9-1.51.7-1.01.1
Saline control response0.30.40.90.9-0.90.9-0.9-0.9-0.2-0.7-0.10.7-0.10.6-0.0-0.1
Bone: connectivity density1.62.56.22.0-2.02.1-2.1-2.2-2.5-1.0-0.31.5-0.70.90.2-0.3
Bone: cortical apparent density0.40.61.30.9-0.90.9-0.8-0.10.90.6-0.7-1.10.5-0.50.7-0.6
Bone: cortical area0.71.12.41.1-1.01.1-1.1-1.4-0.8-1.10.61.6-1.01.1-0.30.6
Bone: cortical porosity0.20.20.80.1-0.10.2-0.2-0.1-0.80.3-0.40.90.3-0.30.4-0.5
Bone: cortical porosity0.20.21.7-0.20.2-0.10.1-0.2-0.9-0.10.11.3-0.20.1-0.20.1
Bone: cortical thickness2.03.37.62.4-2.42.4-2.4-2.8-1.2-1.60.21.8-1.41.6-0.10.3
Bone: cortical thickness0.70.81.80.2-0.20.2-0.1-0.90.5-1.41.11.2-1.21.3-1.01.0
Bone: cortical tissue density0.30.51.60.8-0.80.8-0.7-0.01.00.6-0.7-1.30.5-0.50.6-0.6
Condit. Reinf. active minus inactive responses0.50.61.9-0.80.8-0.90.91.01.40.40.3-1.20.2-0.4-0.30.5
Condit. Reinf. active-inactive response ratio0.70.82.6-1.01.0-1.11.11.01.60.20.5-1.2-0.0-0.3-0.30.7
Condit. Reinf. active responses0.20.31.4-0.20.2-0.20.20.61.10.5-0.1-1.20.4-0.50.1-0.0
Condit. Reinf. inactive responses0.10.20.40.6-0.60.6-0.6-0.5-0.2-0.0-0.20.10.10.1-0.0-0.4
Incentive salience index mean0.10.10.40.0-0.10.0-0.00.30.30.5-0.3-0.70.4-0.50.3-0.2
Condit. Reinf. lever presses0.20.30.80.7-0.70.7-0.7-0.7-0.9-0.3-0.20.7-0.10.30.1-0.2
Condit. Reinf. active minus inactive responses0.20.41.10.8-0.80.8-0.7-0.41.1-0.2-0.1-0.90.00.10.1-0.3
Condit. Reinf. active-inactive response ratio0.71.12.3-0.90.9-0.90.90.00.9-1.11.50.3-1.21.1-1.51.5
Condit. Reinf. active responses0.60.82.50.8-0.80.7-0.70.21.60.6-0.7-1.60.9-0.70.8-1.0
Condit. Reinf. inactive responses0.81.12.10.9-0.90.9-0.90.10.71.0-1.2-1.31.3-1.11.3-1.5
Condit. Reinf. lever presses0.40.51.3-0.60.6-0.60.61.10.10.9-0.5-0.61.0-1.00.4-0.6
Condit. Reinf. lever reinforcers received0.70.92.60.9-0.90.9-0.80.11.30.7-0.8-1.60.9-0.80.9-1.1
Conditioned reinforcement - actives0.10.30.80.1-0.10.0-0.00.60.90.7-0.6-0.80.7-0.60.5-0.6
Conditioned reinforcement - inactives0.10.31.5-0.60.6-0.50.50.3-0.5-0.10.70.80.10.1-1.20.1
Conditioned locomotion1.21.84.8-1.41.4-1.41.42.21.31.6-0.4-0.91.6-1.50.2-0.9
Patch foraging indifference point 0 sec0.20.71.51.0-1.01.0-0.9-0.2-0.50.7-0.8-0.31.0-0.80.6-1.2
Patch foraging indifference point AUC0.20.52.6-0.10.10.0-0.10.3-1.60.6-0.61.10.7-0.50.7-0.6
Delay disc. indifference point, 0s delay0.20.30.50.4-0.40.3-0.30.10.60.4-0.7-0.70.6-0.40.7-0.6
Delay disc. indifference point, 16s delay0.40.61.20.7-0.70.7-0.7-0.3-0.30.8-1.0-0.90.9-0.71.1-0.6
Delay disc. indifference point, 2s delay0.60.71.70.0-0.10.1-0.10.7-0.31.2-1.2-0.41.3-1.21.3-0.9
Delay disc. indifference point, 24s delay1.11.84.1-0.40.4-0.30.31.60.42.0-1.6-1.61.9-2.01.6-0.9
Delay disc. indifference point, 4s delay2.42.55.11.3-1.31.3-1.30.30.21.9-2.2-1.31.8-2.02.3-1.8
Delay disc. indifference point, 8s delay0.20.31.00.7-0.70.7-0.7-0.40.40.3-0.7-0.60.2-0.31.00.1
Indifference point function ln k0.20.52.80.1-0.1-0.00.1-0.41.7-0.80.6-0.9-0.70.7-0.60.5
Indifference point function log k0.20.52.80.1-0.1-0.00.1-0.41.7-0.80.6-0.9-0.70.7-0.60.5
Patch foraging total patch changes 0 sec0.20.71.50.9-0.90.9-0.9-0.2-0.50.8-0.9-0.11.1-0.80.6-1.2
Patch foraging total patch changes 12 sec0.81.02.30.8-0.90.9-0.9-0.0-0.71.0-1.3-0.51.3-1.01.5-1.5
Patch foraging total patch changes 18 sec0.00.00.1-0.20.2-0.20.20.30.00.30.3-0.30.2-0.2-0.2-0.1
Patch foraging total patch changes 24 sec0.62.26.11.2-1.21.3-1.30.2-0.71.5-1.7-0.92.0-1.51.7-2.5
Patch foraging total patch changes 6 sec1.11.83.61.1-1.11.2-1.20.0-1.61.5-1.70.21.7-1.41.6-1.9
Patch foraging time to switch 0 sec0.10.51.40.2-0.20.1-0.1-0.70.4-1.00.9-0.4-1.21.0-0.51.1
Patch foraging water rate 0 sec0.10.40.8-0.60.5-0.50.50.7-0.60.8-0.30.90.9-0.8-0.0-0.7
Patch foraging water rate 12 sec0.20.91.80.6-0.60.7-0.70.1-1.21.1-1.20.61.2-1.11.0-1.3
Patch foraging water rate 18 sec0.20.51.3-0.10.1-0.10.10.80.70.7-0.6-1.01.0-0.80.4-1.1
Patch foraging water rate 24 sec0.50.72.1-1.01.0-1.01.01.11.40.20.3-0.60.3-0.3-0.80.2
Patch foraging water rate 6 sec0.81.12.7-0.40.4-0.40.31.3-0.11.6-1.1-0.81.6-1.51.1-1.3
Seeking ratio, delayed vs. immediate footshock0.40.51.3-0.00.0-0.0-0.00.60.11.2-0.9-0.81.1-1.10.7-0.9
Distance traveled before self-admin0.40.91.8-1.21.2-1.21.21.31.00.8-0.3-0.60.9-0.90.60.0
Distance traveled after self-admin2.13.710.7-1.31.3-1.31.32.63.32.2-1.2-2.62.1-2.11.3-1.1
Extensor digitorum longus weight4.417.644.04.8-4.74.7-4.6-6.6-3.0-5.01.33.7-4.35.0-1.51.2
Bone: elastic displacement1.21.53.31.1-1.11.1-1.1-1.8-0.6-1.70.81.2-1.61.7-0.50.5
Bone: elastic work1.72.35.11.2-1.21.2-1.1-2.1-0.4-2.31.21.4-2.02.2-0.90.9
Bone: endosteal estimation1.02.44.9-2.22.2-2.22.22.12.00.40.9-1.00.2-0.4-0.80.9
Bone: endosteal perimeter0.51.22.5-1.61.6-1.51.51.00.5-0.31.10.4-0.40.2-0.91.3
Epididymis fat weight0.21.13.3-0.70.7-0.70.71.10.91.3-0.8-1.81.3-1.21.2-0.7
Delta time in closed arm before/after self-admin0.20.20.80.5-0.50.5-0.5-0.3-0.90.0-0.7-0.2-0.10.10.6-0.3
Delta time in open arm before/after self-admin0.20.20.5-0.60.6-0.60.60.2-0.70.3-0.40.10.2-0.30.30.3
Diff in mean of infusions in LGA sessions1.01.83.3-1.11.1-1.21.20.01.8-1.41.80.0-1.71.4-1.51.6
Delay discount exponential model param1.01.33.5-0.60.6-0.60.6-0.4-0.1-1.51.71.2-1.51.6-1.91.0
Extinction: sum of active levers before priming0.30.51.6-0.50.4-0.40.40.9-1.00.8-0.2-0.30.8-0.70.3-1.3
Active lever presses in extinction session 61.21.22.8-1.61.5-1.51.51.70.90.60.0-1.00.6-0.8-0.4-0.0
Bone: final force0.20.40.8-0.70.7-0.70.70.20.1-0.30.80.4-0.60.3-0.70.9
Bone: final moment0.30.50.9-0.90.9-0.90.90.60.6-0.10.70.1-0.30.1-0.70.9
Food consumed during 24 hour testing period0.20.30.70.7-0.70.8-0.8-0.8-0.6-0.5-0.20.6-0.20.40.4-0.1
Glucose0.81.33.3-0.90.9-0.90.91.61.81.3-0.5-1.51.1-1.20.6-0.4
Heart weight0.50.81.6-0.30.3-0.30.3-0.8-1.0-1.11.30.8-1.11.1-1.10.9
Delay discount hyperbolic model param1.21.54.1-0.70.8-0.80.8-0.30.2-1.61.91.0-1.61.6-2.01.1
Intermittent access intake day 1-15 change0.10.73.3-0.50.4-0.50.50.71.80.5-0.0-1.60.5-0.6-0.7-0.0
Intermittent access intake escalation0.10.63.6-0.30.3-0.40.40.51.90.40.0-1.50.3-0.5-0.70.1
Intermittent access intake escalation 20.61.02.0-0.80.8-0.80.81.41.11.3-0.3-1.21.2-1.2-0.2-1.0
Intermitt. access day 1 inactive lever presses0.22.04.62.1-2.12.1-2.1-1.2-1.20.3-1.00.20.8-0.40.7-1.6
Intermitt. access day 15 inactive lever presses0.20.82.1-0.70.7-0.70.7-0.2-1.0-0.91.31.5-0.80.7-1.40.7
Intermitt. access escalation Index0.72.03.1-1.71.7-1.71.70.61.5-1.41.7-0.4-1.51.3-1.31.3
Intermittent access day 1 total infusions0.10.30.8-0.90.9-0.90.80.8-0.20.40.10.30.2-0.1-0.3-0.1
Intermittent access day 15 total infusions0.30.81.7-0.80.8-0.80.81.31.11.2-0.5-0.91.1-1.0-0.1-0.6
Intermittent access terminal intake (last 3 days)0.81.43.4-1.21.1-1.11.11.80.51.7-0.8-0.61.6-1.40.1-1.2
Intermittent access total infusions0.50.61.3-0.90.9-0.90.81.10.11.1-0.40.10.8-0.7-0.3-0.6
Intermittent access day 1 locomotion0.10.20.6-0.70.7-0.60.60.70.50.30.20.10.3-0.2-0.5-0.1
Intermittent access day 15 total locomotion0.62.46.6-0.10.0-0.00.01.40.32.5-1.6-1.52.6-2.51.3-1.8
Intermittent access total locomotion1.01.22.6-1.41.4-1.41.41.61.11.0-0.2-0.71.1-0.9-0.5-0.5
Intermittent access standard deviation0.10.72.00.5-0.50.6-0.60.2-0.51.4-1.10.01.4-1.20.2-1.1
Left kidney weight0.10.92.3-0.60.7-0.60.6-0.2-0.8-1.01.41.5-0.81.0-1.40.9
Right kidney weight0.42.55.2-2.32.3-2.22.21.2-0.8-0.41.81.2-0.60.4-2.01.4
Cocaine induced anxiety1.54.26.9-1.91.9-2.02.00.22.2-2.22.60.4-2.32.1-2.52.6
Post-drug Anxiety1.92.14.7-0.90.9-1.01.0-0.41.7-2.01.70.1-1.91.9-1.52.2
Baseline Anxiety1.01.74.71.4-1.41.4-1.4-0.40.10.9-1.9-1.11.2-1.22.2-1.2
Tail length1.57.816.7-4.14.0-4.04.04.13.11.60.9-1.41.2-1.6-0.80.7
Length with tail3.113.529.5-5.45.4-5.45.45.03.71.22.1-2.20.7-1.2-2.01.8
Length without tail0.52.85.4-2.32.3-2.32.32.21.80.41.2-1.60.0-0.4-1.30.9
Times rat made contact with spout0.80.97.40.0-0.00.1-0.1-0.8-2.7-0.50.01.8-0.30.5-0.2-0.0
Lifetime Intake0.40.51.0-0.90.9-0.80.81.0-0.10.9-0.30.70.6-0.5-0.4-0.4
Liver weight, left0.50.92.1-0.50.5-0.40.41.20.01.3-1.0-0.31.4-1.30.8-1.4
Liver weight, right1.11.94.50.3-0.30.3-0.41.00.11.8-1.9-0.72.0-1.81.9-2.1
Locomotor activity0.20.31.00.1-0.10.1-0.10.50.10.8-0.9-0.61.0-0.70.6-0.6
Locomotor testing distance0.30.71.40.9-0.90.9-0.9-0.10.11.0-1.2-0.91.0-0.90.8-0.7
Locomotor testing rearing0.20.71.21.1-1.11.1-1.1-0.20.20.9-1.0-0.70.9-0.90.6-0.7
Locomotion in novel chamber0.91.23.40.1-0.20.1-0.10.80.81.7-1.4-1.91.3-1.51.3-0.8
Locomotion in novel chamber post-restriction0.20.51.4-0.30.3-0.30.30.8-0.81.1-0.7-0.51.0-1.20.4-0.3
Fecal boli incidents, locomotor time 10.20.42.3-0.40.4-0.40.3-0.30.3-0.60.21.1-0.90.6-0.31.5
Change in fecal boli incidents, locomotor task0.80.81.7-1.11.1-1.11.10.81.3-0.31.2-0.2-0.50.3-1.00.7
Time >=10cm from walls, locomotor time 11.11.42.5-0.91.0-0.91.00.41.5-1.21.41.2-1.11.1-1.41.6
Bouts of movement, locomotor time 10.20.20.5-0.50.5-0.50.50.70.40.6-0.1-0.20.3-0.50.3-0.3
Total resting periods, locomotor time 10.30.40.8-0.80.8-0.80.80.90.70.5-0.1-0.30.3-0.50.4-0.3
Rest time, locomotor task time 10.40.71.5-1.21.2-1.21.20.91.1-0.10.6-0.2-0.30.1-0.40.2
Distance moved, locomotor task time 10.10.21.10.3-0.30.3-0.3-0.5-0.9-0.1-0.11.0-0.00.2-0.3-0.2
Vertical activity count, locomotor time 10.10.51.3-0.30.2-0.30.30.80.01.2-0.8-1.01.1-1.00.5-0.6
Time >=10cm from walls, locomotor time 20.30.81.6-0.10.1-0.10.1-0.50.5-1.11.11.1-1.11.1-1.31.3
Bouts of movement, locomotor time 20.51.53.20.2-0.20.2-0.21.0-0.01.6-1.5-1.71.6-1.81.8-1.4
Total resting periods, locomotor time 20.31.12.20.0-0.10.0-0.10.8-0.11.4-1.2-1.51.3-1.51.5-1.3
Rest time, locomotor task time 20.30.61.0-0.60.6-0.50.51.0-0.71.0-0.70.70.8-1.00.6-0.7
Distance moved, locomotor task time 20.50.71.70.5-0.50.4-0.4-1.20.0-1.20.80.1-1.01.3-1.10.4
Vertical activity count, locomotor time 20.20.43.1-0.00.0-0.10.20.21.4-0.00.2-1.70.10.2-0.4-0.0
Light reinforcement 10.10.63.00.3-0.30.4-0.40.3-1.70.9-0.90.21.1-1.00.4-0.9
Light reinforcement 20.81.89.60.9-0.91.1-1.1-0.4-3.10.8-1.31.71.1-1.01.0-1.1
Bone: marrow area0.92.24.4-2.12.1-2.12.11.91.90.40.9-1.00.2-0.4-0.70.8
Bone: maximum diameter0.51.02.1-0.50.5-0.50.5-0.4-0.1-1.31.41.1-1.31.2-1.31.4
Bone: maximum force0.10.31.2-0.40.4-0.30.3-0.0-0.5-0.40.61.1-0.60.4-0.50.7
Bone: maximum moment0.10.30.7-0.60.7-0.60.60.4-0.0-0.20.60.8-0.30.2-0.50.7
Mean time between licks in bursts0.21.32.8-1.71.7-1.71.71.31.30.20.8-0.7-0.2-0.2-0.80.7
Mean num. licks in bursts0.61.69.11.0-1.01.0-1.1-1.3-3.0-0.4-0.52.1-0.10.40.1-0.3
Cd content in liver2.83.16.7-0.40.4-0.50.5-1.50.9-2.62.31.3-2.62.6-2.32.3
Co content in liver0.60.72.6-0.80.8-0.80.80.71.60.10.7-1.1-0.2-0.1-0.71.1
Cu content in liver0.10.10.60.2-0.20.3-0.30.1-0.30.2-0.40.70.4-0.20.3-0.5
Fe content in liver0.50.61.6-0.40.5-0.40.50.1-0.1-0.71.10.8-0.90.7-1.31.2
K content in liver1.81.83.51.3-1.31.3-1.4-0.2-1.51.4-1.80.01.4-1.31.9-1.3
Mg content in liver0.30.31.20.2-0.20.3-0.30.1-1.10.6-0.60.80.5-0.60.9-0.1
Mn content in liver1.01.12.61.5-1.51.5-1.5-1.60.2-0.8-0.30.3-0.50.80.40.6
Na content in liver3.13.56.81.5-1.51.6-1.7-0.1-2.61.7-2.50.22.0-1.72.6-2.3
Rb content in liver0.91.03.1-1.11.1-1.21.20.71.8-0.51.0-0.7-0.70.5-0.91.0
Se content in liver0.81.02.40.6-0.60.6-0.60.2-1.51.2-1.3-0.31.4-1.21.3-0.8
Sr content in liver1.31.22.50.2-0.20.2-0.2-1.2-0.5-1.61.11.3-1.51.6-1.41.2
Zn content in liver0.30.30.70.8-0.80.9-0.9-0.6-0.60.2-0.50.40.3-0.10.5-0.1
Bone: minimum diameter1.93.68.8-2.82.8-2.72.73.01.61.20.6-0.51.1-1.3-0.20.6
Time in familiar zone, hab. session 11.82.03.71.9-1.91.9-1.9-1.2-1.70.4-1.41.10.5-0.31.5-1.2
Time in novel zone, hab. session 14.04.49.7-3.13.1-3.13.12.42.20.21.5-1.5-0.1-0.2-1.71.2
Total zone transitions, hab. session 12.53.56.21.5-1.51.5-1.50.4-0.52.1-2.4-1.92.4-2.22.5-2.5
Total locomotion distance, hab. session 12.73.87.71.4-1.41.5-1.50.2-1.82.3-2.80.02.4-2.32.7-2.7
Locomotion velocity, hab. session 13.04.27.91.9-2.02.0-2.1-0.4-2.02.0-2.80.22.1-2.02.7-2.6
Time in familiar zone, hab. session 20.60.74.80.0-0.00.1-0.2-0.3-2.10.0-0.22.2-0.00.00.10.1
Time in novel zone, hab. session 21.11.36.7-0.70.7-0.80.90.72.6-0.10.7-2.4-0.10.1-0.50.2
Total zone transitions, hab. session 20.10.20.50.4-0.50.4-0.4-0.20.10.2-0.4-0.70.4-0.20.5-0.5
Total locomotion distance, hab. session 20.30.30.80.4-0.40.4-0.4-0.0-0.60.7-0.9-0.20.7-0.70.8-0.8
Locomotion velocity, hab. session 20.70.92.00.8-0.80.8-0.8-0.1-0.81.0-1.4-0.21.1-1.01.4-1.2
Novel to familiar place preference ratio0.20.30.60.2-0.20.2-0.20.3-0.70.7-0.70.20.7-0.70.6-0.7
Novelty place preference0.30.30.7-0.00.00.0-0.00.5-0.70.8-0.70.30.8-0.80.6-0.8
Time in novel zone, NPP test0.40.51.1-0.10.1-0.10.10.7-0.51.0-0.8-0.11.0-1.00.7-0.9
Total zone transitions, NPP test0.50.82.01.4-1.41.4-1.3-1.20.4-0.5-0.2-0.4-0.30.40.2-0.1
Total locomotion distance, NPP test0.91.22.21.4-1.41.5-1.5-0.8-1.30.5-1.20.90.6-0.61.0-1.0
Locomotion velocity, NPP test0.91.32.91.7-1.71.7-1.7-1.1-1.20.2-1.00.90.3-0.20.8-0.8
Intraocular pressure0.91.53.8-1.91.9-1.91.91.40.30.10.9-0.30.1-0.1-0.90.2
Delta distance traveled before/after self-admin1.31.46.90.1-0.10.00.01.02.61.3-0.8-2.21.0-1.10.9-0.7
Delta ambulatory time before/after self-admin0.71.28.70.1-0.10.1-0.00.72.90.8-0.4-2.20.5-0.50.6-0.4
Parametrial fat weight0.30.81.6-1.11.1-1.11.11.30.41.00.3-0.40.8-1.1-0.60.1
Pavlov. Cond. lever latency0.60.81.5-0.60.6-0.60.6-0.2-0.0-0.91.21.2-1.11.0-1.11.2
Pavlov. Cond. magazine entry latency0.40.51.20.8-0.80.8-0.8-0.3-0.60.5-1.0-0.80.7-0.51.1-0.7
Pavlov. Cond. change in total contacts0.40.41.60.5-0.50.4-0.40.10.60.5-0.7-1.30.6-0.50.7-0.6
Pavlov. Cond. index score1.01.32.41.2-1.21.2-1.2-0.3-0.30.9-1.5-1.21.2-0.91.5-1.4
Pavlov. Cond. latency score0.70.91.51.1-1.11.1-1.1-0.4-0.30.7-1.2-0.90.9-0.71.2-1.1
Pavlov. Cond. lever contacts0.60.81.90.9-0.90.8-0.8-0.10.40.7-1.1-1.40.8-0.71.0-1.1
Pavlov. Cond. magazine entry number0.60.82.2-0.80.8-0.80.80.1-0.1-0.71.11.5-0.90.7-1.20.9
Pavlov. Cond. intertrial magazine entries0.60.71.50.8-0.80.8-0.80.20.40.9-1.2-0.61.0-0.91.1-1.2
Pavlov. Cond. lever-magazine prob. diff.1.11.42.51.2-1.21.2-1.2-0.3-0.30.9-1.5-1.31.2-0.91.6-1.4
Pavlov. Cond. response bias0.91.12.40.7-0.80.7-0.70.20.11.1-1.4-1.61.3-1.11.5-1.3
Pavlov. Cond. lever latency0.20.32.80.2-0.20.2-0.10.01.7-0.10.2-0.9-0.20.1-0.2-0.0
Pavlov. Cond. magazine entry latency0.60.92.0-1.41.4-1.41.40.6-0.1-0.31.00.4-0.50.3-1.01.0
Pavlov. Cond. change in total contacts0.10.32.20.2-0.20.3-0.3-0.3-1.50.1-0.40.90.3-0.10.4-0.3
Pavlov. Cond. index score0.40.61.1-1.11.1-1.01.00.3-1.0-0.30.70.9-0.30.3-0.70.8
Pavlov. Cond. latency score0.40.71.5-0.80.8-0.80.8-0.1-1.1-0.70.91.2-0.70.7-0.90.9
Pavlov. Cond. lever contacts0.20.42.2-0.60.6-0.50.50.5-1.50.3-0.20.80.5-0.40.20.1
Pavlov. Cond. magazine entry number0.60.71.21.0-1.01.0-1.0-0.20.30.6-1.1-0.50.7-0.61.1-1.1
Pavlov. Cond. intertrial magazine entries0.00.10.40.1-0.10.1-0.10.20.60.3-0.3-0.50.4-0.30.3-0.2
Pavlov. Cond. lever-magazine prob. diff.0.40.71.2-1.11.1-1.11.10.4-1.1-0.30.70.8-0.30.3-0.70.8
Pavlov. Cond. response bias0.30.40.9-0.90.9-0.90.90.8-0.80.5-0.00.00.5-0.60.10.2
Time in closed arm before self-admin0.30.62.9-0.50.5-0.50.5-0.10.5-0.91.3-0.3-0.70.6-1.70.5
Time in closed arm after self-admin0.40.51.11.1-1.11.1-1.0-0.8-0.4-0.4-0.5-0.5-0.10.20.1-0.5
Time in open arm before self-admin0.10.21.1-0.30.3-0.30.30.71.00.1-0.0-0.3-0.00.00.50.2
Time in open arm after self-admin0.91.01.9-1.21.2-1.21.11.4-0.31.2-0.8-0.11.0-1.21.0-0.1
Bone: periosteal estimation0.30.61.2-0.90.9-0.90.90.61.0-0.51.10.1-0.50.4-0.81.0
Bone: periosteal perimeter0.10.21.10.1-0.00.1-0.1-0.2-0.7-0.40.41.1-0.40.4-0.20.5
Bone: post-yield work0.81.43.3-1.81.8-1.71.71.4-0.60.40.51.30.2-0.4-0.70.7
Progressive ratio test 1 active lever presses1.01.74.3-1.81.8-1.71.72.1-0.51.6-0.30.31.3-1.1-0.1-0.5
Progressive ratio test 1 breakpoint1.01.64.1-1.71.7-1.61.62.0-0.51.6-0.30.31.3-1.2-0.1-0.5
Progressive ratio test 1 inactive lever presses0.20.42.60.3-0.30.4-0.4-0.3-1.20.20.01.60.4-0.2-0.4-0.5
Progressive ratio test 2 active lever presses0.81.12.7-1.31.3-1.21.21.6-0.31.3-0.30.51.3-1.00.0-0.8
Progressive ratio test 2 breakpoint0.81.12.6-1.31.2-1.21.11.6-0.31.3-0.30.51.3-1.00.1-0.7
Progressive ratio test 2 inactive lever presses0.20.50.8-0.70.7-0.70.60.8-0.50.80.00.90.9-0.7-0.5-0.6
Incentive Sensitization - Responses0.30.71.6-1.31.3-1.31.31.20.90.10.5-0.40.4-0.1-0.5-0.1
Incentive Sensitization - Breakpoint0.30.81.7-1.31.3-1.31.31.20.90.10.5-0.40.4-0.1-0.5-0.1
Sum of active levers in priming session hrs 5-60.40.41.70.4-0.40.5-0.5-0.2-1.00.4-0.61.30.7-0.30.5-0.5
Progressive ratio0.10.20.60.4-0.40.4-0.4-0.4-0.4-0.6-0.10.8-0.40.6-0.1-0.3
Food seeking constrained by brief footshock0.20.31.20.3-0.30.3-0.3-0.5-0.3-0.70.7-0.3-0.50.6-1.1-0.3
Seeking ratio, punishment vs. effort0.00.10.2-0.20.2-0.20.20.2-0.30.40.2-0.50.4-0.4-0.1-0.3
Retroperitoneal fat weight0.41.93.3-1.71.7-1.81.81.71.80.50.7-1.80.4-0.5-1.00.4
Reaction time number correct0.20.71.5-1.21.2-1.21.20.71.0-0.30.7-0.8-0.30.2-0.60.8
Reaction time mean minus median0.21.12.1-1.51.5-1.41.40.8-0.2-0.51.31.0-0.50.6-1.00.5
Reaction time mean minus median AUC0.21.52.7-1.71.7-1.61.60.6-0.3-0.81.71.3-0.70.9-1.20.5
Reaction time num false alarms0.81.42.81.0-1.01.0-1.0-0.00.11.3-1.6-1.01.4-1.41.7-1.5
Reaction time num false alarms AUC0.61.52.81.0-1.01.0-1.00.00.11.3-1.6-1.21.5-1.41.7-1.6
Reaction time trials correct on left0.20.71.5-1.21.2-1.21.20.71.0-0.30.7-0.8-0.30.2-0.60.8
Reaction time trials on left0.20.81.5-1.21.2-1.21.20.71.1-0.30.8-0.8-0.40.2-0.70.9
Reaction time mean0.71.62.8-1.61.6-1.61.60.71.2-0.81.70.5-1.00.9-1.31.3
Reaction time mean AUC0.51.32.4-1.51.5-1.51.50.91.2-0.41.40.2-0.60.6-1.01.1
Median of all reaction times0.91.42.2-1.41.4-1.51.50.61.5-0.71.50.1-1.10.8-1.11.5
Reaction time omissions0.81.33.3-0.30.4-0.40.4-0.61.0-1.81.80.6-1.41.7-1.51.2
Reaction time false alarm rate1.31.93.61.2-1.31.2-1.3-0.1-0.41.5-1.9-0.81.6-1.51.9-1.8
Reaction time premature initiation rate0.30.51.40.7-0.70.7-0.7-0.1-0.70.8-0.9-0.21.2-0.80.7-0.6
Reaction time premature initiations0.10.21.00.1-0.10.1-0.10.2-0.30.6-0.4-0.61.0-0.60.3-0.3
Std. dev. reaction times0.31.01.9-1.31.3-1.31.30.80.7-0.51.40.5-0.50.6-1.00.6
Reaction time trials completed0.20.81.5-1.21.2-1.21.20.71.1-0.30.8-0.8-0.40.2-0.70.9
Reaction time trials AUC0.31.12.0-1.41.4-1.41.40.81.3-0.41.0-0.9-0.50.3-0.91.0
Run reversals in cocaine runway, females0.20.30.90.6-0.60.6-0.6-0.10.20.6-0.3-0.20.4-0.50.2-0.9
Run reversals in cocaine runway, males1.11.22.9-0.30.3-0.30.3-0.9-0.3-1.71.60.5-1.61.7-1.51.2
Latency to leave start box in cocaine runway0.60.82.2-1.01.0-1.01.01.50.21.0-0.6-1.20.9-1.00.5-0.3
Latency to leave start box in cocaine runway, F0.81.12.3-0.40.4-0.40.31.4-0.31.5-1.2-0.81.5-1.51.1-1.1
Latency to leave start box in cocaine runway, M1.01.01.8-1.31.3-1.31.30.71.1-0.40.9-0.9-0.70.4-0.81.1
Std. dev. time between licks in bursts0.20.30.7-0.50.5-0.50.50.80.90.6-0.3-0.00.5-0.60.4-0.1
Total sessions with >9 infusions0.30.41.6-0.70.7-0.60.60.8-0.50.6-0.11.30.4-0.3-0.4-0.1
Short access day 1 total inactive lever presses0.20.40.9-0.20.1-0.10.10.6-0.20.8-0.8-0.01.0-0.90.8-0.9
Short access day 10 total inactive lever presses0.21.23.21.7-1.71.7-1.6-1.8-0.4-0.80.20.4-0.60.6-0.3-0.1
Short access day 1 total infusions0.71.33.40.3-0.30.4-0.40.7-1.31.8-1.50.81.5-1.41.5-1.4
Short access day 10 total infusions0.61.02.10.3-0.30.4-0.40.6-1.01.4-1.11.31.4-1.10.7-1.4
Short access total infusions0.20.32.1-0.40.4-0.30.30.4-0.60.4-0.11.40.3-0.0-0.3-0.3
Short access day 1 locomotion1.01.64.3-0.70.7-0.60.61.80.92.1-1.3-0.51.7-1.81.1-1.3
Short access day 10 total locomotion0.10.51.30.4-0.40.4-0.40.40.11.0-0.90.41.1-1.00.7-0.8
Short access total locomotion0.30.51.3-0.40.4-0.30.31.10.31.0-0.50.71.1-0.90.0-0.8
One hour access (0.3 mA shock)1.92.35.2-1.91.9-1.91.92.31.61.7-0.2-1.31.2-1.4-0.2-0.4
Compulsive drug intake0.91.33.11.6-1.61.6-1.5-1.8-0.5-1.20.40.3-1.01.1-0.10.2
One hour access (shock baseline)1.02.76.4-1.71.6-1.61.52.50.62.5-1.0-0.72.0-2.20.5-1.0
Social response proportion0.20.21.4-0.60.6-0.60.60.2-0.2-0.30.41.2-0.20.2-0.20.1
Social responses0.70.92.9-0.10.1-0.10.11.00.91.0-0.9-1.71.2-1.20.9-1.1
Social time0.20.30.5-0.70.7-0.70.70.50.6-0.20.4-0.40.10.3-0.50.0
Soleus weight2.67.518.24.3-4.34.2-4.2-3.6-1.5-1.0-1.70.4-0.41.01.7-1.7
Bone: stiffness0.71.23.10.2-0.20.3-0.30.9-0.81.8-1.5-0.11.6-1.71.3-1.2
Tibialis anterior weight1.86.214.03.5-3.43.4-3.4-3.7-2.5-1.9-0.71.8-1.31.80.4-0.7
Time to tail flick, vehicle, before self-admin0.91.12.5-1.61.5-1.61.61.41.00.4-0.1-1.10.3-0.40.00.2
Time to tail flick, vehicle, after self-admin0.30.62.80.4-0.40.4-0.30.50.80.5-0.8-1.70.9-0.71.0-1.0
Time to tail flick, test, before self-admin0.30.41.4-0.30.3-0.30.3-0.20.3-0.80.5-0.6-0.80.7-1.20.8
Time to tail flick, test, after self-admin1.21.33.4-1.51.5-1.51.51.81.20.30.1-1.30.4-0.4-0.1-0.0
Delta time to tail flick, vehicle, before/after SA0.50.51.31.1-1.11.1-1.1-0.6-0.5-0.1-0.4-0.20.4-0.00.2-0.9
Delta time to tail flick, test, before/after SA0.40.51.3-0.50.5-0.50.41.20.20.8-0.6-0.10.9-0.81.1-0.7
Tibia length1.33.59.4-2.32.3-2.32.31.43.1-0.82.0-0.4-0.90.7-1.82.0
Ambulatory time before self-admin0.20.71.5-0.60.6-0.60.61.10.51.0-0.8-0.51.2-1.10.8-0.4
Ambulatory time after self-admin2.03.39.7-0.80.8-0.90.92.13.12.1-1.3-2.92.1-1.91.4-1.2
Bone: tissue strength0.30.30.6-0.10.1-0.00.00.6-0.80.8-0.60.10.6-0.80.6-0.6
Total heroin consumption2.12.49.0-1.71.7-1.71.82.03.00.30.2-2.60.4-0.40.20.2
Bone: trabecular number0.91.63.51.9-1.81.9-1.9-1.6-1.6-0.4-0.61.1-0.20.40.4-0.7
Bone: trabecular spacing0.10.10.50.1-0.10.1-0.10.10.70.4-0.5-0.20.4-0.40.5-0.2
Bone: trabecular thickness0.40.51.21.1-1.11.1-1.1-0.9-1.0-0.5-0.10.4-0.30.40.1-0.3
Bone: trabecular tissue density0.10.10.30.4-0.40.4-0.40.20.50.2-0.2-0.20.2-0.2-0.2-0.2
Water consumed over 24 hours0.10.10.7-0.30.3-0.30.2-0.1-0.8-0.20.10.8-0.00.2-0.10.1
Number of responses in last shaping day1.72.26.70.9-1.01.0-1.00.3-0.42.1-2.6-0.51.7-1.92.2-1.5