Afm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Afm	0.2	0.08	0.0e+00	0.11	0.17	0.18	0.18	1.6e-12	1.0e-18	5.9e-20	4.2e-20
2	Adipose	gene expression	Afm	0.04	0.04	1.8e-03	0.02	0.01	0.01	0.02	6.1e-03	1.2e-02	1.4e-02	1.9e-03
3	Liver	mRNA stability	Afm	0.29	0.09	0.0e+00	0.31	0.32	0.3	0.31	3.9e-35	5.6e-36	4.1e-34	2.5e-35
4	Liver	isoform ratio	NM_172320.2	0.12	0.06	2.4e-14	0.11	0.11	0.1	0.11	3.4e-12	3.8e-12	1.2e-11	6.9e-12
5	Liver	isoform ratio	XM_039091644.1	0.12	0.06	2.6e-15	0.12	0.12	0.11	0.12	8.9e-13	8.3e-13	7.2e-12	4.4e-13
6	pVTA	gene expression	Afm	0.14	0.07	4.3e-06	0.14	0.14	0.13	0.12	1.8e-06	1.6e-06	2.3e-06	8.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.2	5.0	-2.2	-0.3	-0.5	0.1	0.3	1.3
Area under the delay curve	1.3	1.4	2.1	0.4	1.2	-1.0	-1.5	-1.4	-1.3
BMI with tail	0.7	2.3	9.8	-3.1	1.2	-0.8	0.4	0.5	1.3
BMI without tail	0.3	0.6	1.9	-1.4	-0.4	0.2	0.6	0.7	0.8
Body weight	0.3	1.4	3.2	-0.3	-0.5	1.8	1.3	1.5	1.1
Weight adjusted by age	0.2	0.3	0.6	-0.0	-0.8	0.4	0.4	0.4	0.7
Bone surface	1.0	1.8	3.3	-1.5	-1.3	0.9	1.1	1.2	1.8
Bone volume	0.5	0.9	2.6	-1.6	-0.6	0.2	0.4	0.5	1.4
Breakpoint value in progressive ratio session	0.1	0.2	0.3	0.0	-0.5	0.6	0.0	0.2	0.5
Number of licking bursts	0.1	0.1	0.4	0.6	-0.0	0.6	-0.1	-0.1	-0.3
Context. condit. distance diff. score	2.8	3.4	5.9	-0.9	2.0	-2.4	-2.0	-2.0	-1.3
Locomotion velocity, session 1	0.9	0.9	2.7	-0.8	1.7	-1.0	-0.7	-0.7	-0.3
Locomotion distance, session 1	1.8	2.3	4.1	-0.8	1.9	-2.0	-1.6	-1.5	-0.9
Locomotion velocity, session 2	0.7	0.8	3.1	-1.1	1.8	-0.6	-0.5	-0.4	-0.2
Locomotion distance, session 2	1.4	1.9	3.6	-0.1	1.9	-1.4	-1.5	-1.4	-1.3
Locomotion velocity, session 3	1.0	1.2	2.4	-0.3	1.2	-1.5	-1.1	-1.2	-0.9
Locomotion distance, session 3	1.6	1.7	3.3	-1.1	1.8	-1.8	-1.1	-1.1	-0.5
Stereotopy head waving bouts, day 3	0.5	0.6	0.8	0.4	0.8	-0.7	-0.8	-0.9	-0.8
Stereotopy head waving duration, day 3	0.5	0.6	0.9	0.5	-0.1	-0.9	-0.9	-0.9	-0.8
Locomotion velocity, session 7	0.9	1.0	1.8	0.4	0.2	-1.3	-1.3	-1.3	-0.9
Locomotion distance, session 7	0.4	0.5	0.9	0.4	-0.1	-0.9	-1.0	-1.0	-0.5
Stereotopy head waving bouts, day 7	0.3	0.3	1.2	-1.1	0.4	-0.3	-0.0	0.0	0.5
Stereotopy head waving duration, day 7	0.0	0.0	0.1	-0.3	0.2	-0.2	-0.1	-0.1	0.0
Locomotion velocity, session 8	3.4	4.0	8.6	-1.2	1.8	-2.9	-2.2	-2.2	-1.1
Locomotion distance, session 8	3.6	5.2	9.0	-1.3	2.6	-3.0	-2.5	-2.4	-1.4
Degree of sensitization distance	0.8	0.8	2.0	1.2	-1.4	1.1	0.4	0.4	0.1
Degree of sensitization stereotypy	0.1	0.1	0.3	-0.5	0.3	0.1	0.1	0.1	0.2
Conditioned locomotion	0.6	0.7	2.2	1.3	-1.5	-0.4	-0.4	-0.4	-0.3
Cocaine response after cond. corrected	0.2	0.2	0.5	0.7	-0.7	0.3	0.2	0.1	-0.0
Cocaine response after cond. not corrected	0.3	0.3	0.6	-0.3	-0.7	0.4	0.6	0.6	0.8
Cocaine response before conditioning	1.1	1.4	3.7	-1.9	-0.1	0.5	0.9	1.0	1.6
Saline control response	0.2	0.2	0.7	-0.8	-0.3	-0.4	0.2	0.1	0.5
Bone: connectivity density	0.6	0.9	3.3	-1.8	-0.4	-0.9	-0.3	-0.2	0.8
Bone: cortical apparent density	0.4	0.5	0.9	-0.4	1.0	-0.8	-0.7	-0.8	-0.5
Bone: cortical area	0.6	0.9	2.7	-1.6	-0.8	-0.1	0.5	0.5	1.2
Bone: cortical porosity	0.3	0.3	1.4	0.4	-1.2	-0.1	-0.1	-0.0	-0.0
Bone: cortical porosity	0.3	0.3	1.7	0.2	-1.3	0.1	0.2	0.2	0.2
Bone: cortical thickness	1.0	1.7	7.4	-2.7	-0.1	-0.8	0.3	0.4	1.4
Bone: cortical thickness	0.9	1.0	1.6	-1.2	-0.8	0.6	1.0	1.0	1.3
Bone: cortical tissue density	0.4	0.5	1.0	-0.4	1.0	-0.7	-0.7	-0.7	-0.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.9	0.3	0.9	0.6	0.3	0.3	-0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	0.8	0.3	0.8	0.3	0.3	-0.0
Condit. Reinf. active responses	0.2	0.3	1.8	-0.0	1.3	0.0	0.1	0.0	-0.2
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.9	0.8	-0.4	0.2	0.2	0.1
Incentive salience index mean	0.1	0.2	0.7	-0.0	0.9	-0.2	-0.2	-0.2	-0.3
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.5	-0.0	-0.6	-0.1	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.5	0.6	1.9	-1.2	1.4	-0.4	-0.2	-0.2	0.0
Condit. Reinf. active-inactive response ratio	1.5	1.6	2.2	-0.8	-0.6	1.5	1.5	1.5	1.3
Condit. Reinf. active responses	0.8	1.0	3.2	-0.8	1.8	-0.8	-0.8	-0.9	-0.6
Condit. Reinf. inactive responses	1.4	1.7	2.4	0.1	1.6	-1.4	-1.5	-1.5	-1.2
Condit. Reinf. lever presses	0.1	0.2	0.4	0.6	-0.0	0.0	-0.4	-0.4	-0.6
Condit. Reinf. lever reinforcers received	0.8	1.1	3.4	-0.8	1.8	-0.9	-0.9	-0.9	-0.7
Conditioned reinforcement - actives	0.6	0.6	1.1	0.8	0.7	-0.3	-0.9	-0.9	-1.1
Conditioned reinforcement - inactives	1.3	1.4	2.4	0.4	-1.5	1.1	1.5	1.5	0.6
Conditioned locomotion	1.0	1.2	4.5	2.1	-1.1	0.6	0.1	0.0	-0.9
Patch foraging indifference point 0 sec	0.4	0.6	1.5	-0.8	0.5	-1.2	-0.4	-0.5	-0.8
Patch foraging indifference point AUC	0.7	0.8	1.5	1.2	-1.1	-0.4	-0.9	-0.8	-0.5
Delay disc. indifference point, 0s delay	0.3	0.3	1.0	-0.5	1.0	-0.3	-0.4	-0.4	-0.5
Delay disc. indifference point, 16s delay	1.1	1.1	1.7	0.0	1.3	-1.0	-1.1	-1.1	-1.1
Delay disc. indifference point, 2s delay	0.7	0.8	1.2	0.9	0.1	-0.7	-1.1	-1.1	-1.1
Delay disc. indifference point, 24s delay	1.7	1.6	2.6	1.6	0.8	-0.7	-1.4	-1.4	-1.5
Delay disc. indifference point, 4s delay	3.3	3.5	5.0	0.3	1.9	-1.9	-2.2	-2.2	-1.9
Delay disc. indifference point, 8s delay	0.4	0.4	1.1	-0.1	1.1	-0.6	-0.7	-0.7	-0.3
Indifference point function ln k	0.7	1.0	2.8	-1.7	1.4	0.3	0.7	0.7	0.5
Indifference point function log k	0.7	1.0	2.8	-1.7	1.4	0.3	0.7	0.7	0.5
Patch foraging total patch changes 0 sec	0.3	0.6	1.6	-0.6	0.4	-1.3	-0.4	-0.5	-0.8
Patch foraging total patch changes 12 sec	1.5	2.0	2.8	0.7	0.7	-1.7	-1.6	-1.7	-1.7
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	0.1	-0.5	0.2	0.3	0.3	0.1
Patch foraging total patch changes 24 sec	2.1	2.5	4.2	0.4	0.8	-2.1	-1.9	-1.8	-1.8
Patch foraging total patch changes 6 sec	1.2	1.7	3.6	0.5	-0.0	-1.9	-1.4	-1.4	-1.6
Patch foraging time to switch 0 sec	0.2	0.3	0.6	-0.6	0.7	0.4	0.4	0.4	0.8
Patch foraging water rate 0 sec	0.3	0.5	2.0	0.6	-1.4	-0.2	-0.1	-0.1	-0.5
Patch foraging water rate 12 sec	0.5	0.7	1.1	0.5	-1.0	-1.0	-0.9	-0.8	-0.7
Patch foraging water rate 18 sec	0.2	0.2	0.7	-0.0	0.9	-0.3	-0.3	-0.3	-0.7
Patch foraging water rate 24 sec	0.3	0.4	0.7	0.4	-0.3	0.9	0.8	0.7	0.1
Patch foraging water rate 6 sec	0.6	0.9	2.0	1.2	0.1	-0.6	-0.9	-0.9	-1.4
Seeking ratio, delayed vs. immediate footshock	0.6	0.7	1.3	0.6	0.8	-0.7	-1.0	-0.8	-1.1
Distance traveled before self-admin	1.1	1.2	4.0	2.0	-0.2	0.1	-0.7	-0.9	-1.4
Distance traveled after self-admin	2.3	2.5	6.6	2.6	1.4	-0.0	-1.0	-1.2	-2.0
Extensor digitorum longus weight	2.4	9.3	37.1	-6.1	0.5	-0.9	1.2	1.4	3.8
Bone: elastic displacement	1.2	1.4	4.1	-2.0	0.1	0.2	0.9	0.8	1.6
Bone: elastic work	1.6	2.0	5.0	-2.2	-0.3	0.5	1.2	1.2	2.0
Bone: endosteal estimation	0.4	0.9	2.1	1.2	-0.8	1.5	0.8	0.7	-0.0
Bone: endosteal perimeter	0.5	1.1	2.2	0.6	-1.5	1.4	0.9	0.9	0.6
Epididymis fat weight	0.4	0.9	1.6	1.3	0.2	-0.1	-1.3	-1.1	-1.0
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.2	0.1	-0.2	-0.5	-0.4	0.1
Delta time in open arm before/after self-admin	0.8	0.8	2.2	1.5	-0.5	-0.1	-0.7	-0.8	-1.1
Diff in mean of infusions in LGA sessions	1.5	1.6	2.8	-0.3	-0.6	1.7	1.5	1.5	1.4
Delay discount exponential model param	1.5	1.6	2.5	-0.6	-1.0	1.1	1.6	1.5	1.3
Extinction: sum of active levers before priming	0.9	0.9	2.2	1.5	-0.7	-0.6	-0.9	-0.7	-1.0
Active lever presses in extinction session 6	0.6	0.6	1.6	0.8	-0.2	1.3	0.8	0.8	0.1
Bone: final force	0.6	0.9	2.2	-0.2	-1.5	1.0	0.9	0.9	0.8
Bone: final moment	0.5	0.8	1.9	0.1	-1.4	1.1	0.8	0.8	0.6
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.3	-0.5	-0.4	-0.2	-0.2	0.2
Glucose	0.5	0.8	2.2	0.7	1.5	-0.2	-0.7	-0.7	-1.1
Heart weight	0.5	0.7	1.8	-0.3	-1.3	0.7	0.8	1.0	0.5
Delay discount hyperbolic model param	2.0	2.1	3.4	-0.6	-1.2	1.4	1.8	1.8	1.6
Intermittent access intake day 1-15 change	0.9	0.9	2.4	-0.5	0.3	0.9	1.6	1.3	0.4
Intermittent access intake escalation	1.2	1.1	3.0	0.0	0.6	1.1	1.7	1.4	0.2
Intermittent access intake escalation 2	1.4	1.4	2.3	1.4	-0.8	1.4	1.5	1.3	-0.1
Intermitt. access day 1 inactive lever presses	1.4	1.5	3.7	-1.9	1.1	-1.8	-0.7	-0.7	0.0
Intermitt. access day 15 inactive lever presses	2.8	3.0	4.5	-0.2	-1.9	1.6	2.1	2.1	1.8
Intermitt. access escalation Index	1.1	1.0	1.9	-0.5	-0.2	1.4	1.1	1.1	1.2
Intermittent access day 1 total infusions	0.4	0.4	0.9	0.9	-0.9	-0.1	-0.2	-0.2	-1.0
Intermittent access day 15 total infusions	0.6	0.7	1.1	1.0	-0.5	0.6	1.0	0.8	-0.9
Intermittent access terminal intake (last 3 days)	1.3	1.4	3.7	1.9	-1.2	1.0	1.0	0.8	-1.0
Intermittent access total infusions	1.0	1.1	2.5	1.6	-1.3	0.6	0.8	0.6	-0.9
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.3	-0.5	0.1	0.4	0.2	-0.5
Intermittent access day 15 total locomotion	1.6	1.7	5.7	1.0	1.0	-0.9	-0.8	-1.1	-2.4
Intermittent access total locomotion	0.4	0.5	1.5	1.0	-0.0	0.4	0.5	0.3	-1.2
Intermittent access standard deviation	0.2	0.2	0.5	0.1	-0.5	-0.5	0.5	0.2	-0.7
Left kidney weight	0.6	1.7	5.5	1.2	-2.3	1.4	0.8	1.0	-0.0
Right kidney weight	0.9	2.6	6.3	2.2	-2.5	1.7	0.6	0.9	-0.1
Cocaine induced anxiety	1.9	2.1	4.3	0.3	-0.5	2.1	1.8	1.6	1.6
Post-drug Anxiety	0.3	0.3	0.9	0.8	0.3	0.9	0.3	0.3	0.2
Baseline Anxiety	4.3	4.6	7.9	0.9	1.8	-2.0	-2.8	-2.6	-2.1
Tail length	0.9	2.8	5.9	2.2	-1.9	2.4	1.0	1.1	0.1
Length with tail	0.9	3.5	10.7	3.3	-1.3	2.6	0.7	0.8	-0.8
Length without tail	0.7	1.5	5.2	2.3	0.9	0.4	-0.6	-0.6	-1.4
Times rat made contact with spout	0.7	0.8	4.0	0.7	-2.0	-0.2	0.0	0.1	0.1
Lifetime Intake	1.0	1.1	3.0	1.6	-1.7	0.6	0.6	0.5	-0.7
Liver weight, left	0.7	1.1	1.6	0.8	-0.2	-1.2	-1.2	-1.2	-1.3
Liver weight, right	1.5	2.4	3.6	1.5	-0.4	-1.5	-1.9	-1.8	-1.7
Locomotor activity	0.2	0.4	0.9	0.3	0.2	-0.6	-1.0	-0.7	-0.7
Locomotor testing distance	0.8	1.4	2.5	-0.5	1.1	-1.6	-1.4	-1.2	-1.0
Locomotor testing rearing	0.4	0.6	1.1	-0.8	0.8	-1.1	-0.7	-0.6	-0.6
Locomotion in novel chamber	1.7	2.1	3.4	0.2	1.8	-1.3	-1.7	-1.6	-1.4
Locomotion in novel chamber post-restriction	0.3	0.4	1.3	0.3	0.5	-0.3	-0.4	-0.4	-1.1
Fecal boli incidents, locomotor time 1	0.3	0.3	1.1	0.5	-1.1	0.6	0.1	0.3	0.5
Change in fecal boli incidents, locomotor task	0.7	0.7	1.6	-0.0	-0.4	1.3	0.9	1.0	0.8
Time >=10cm from walls, locomotor time 1	1.7	1.7	3.4	-0.1	-1.8	1.3	1.5	1.3	1.2
Bouts of movement, locomotor time 1	0.1	0.2	0.5	0.7	-0.3	-0.0	-0.3	-0.2	-0.5
Total resting periods, locomotor time 1	0.3	0.4	1.3	1.1	-0.4	0.1	-0.5	-0.3	-0.6
Rest time, locomotor task time 1	0.2	0.2	1.0	1.0	-0.3	0.6	0.0	0.1	-0.1
Distance moved, locomotor task time 1	0.3	0.3	1.2	0.2	-1.1	-0.1	0.5	0.4	0.2
Vertical activity count, locomotor time 1	0.4	0.4	1.1	0.3	0.6	-0.4	-0.5	-0.6	-1.0
Time >=10cm from walls, locomotor time 2	0.9	0.9	1.5	-0.6	-0.8	0.7	1.1	1.1	1.2
Bouts of movement, locomotor time 2	1.9	2.0	3.6	0.7	1.3	-1.0	-1.9	-1.7	-1.6
Total resting periods, locomotor time 2	1.3	1.4	2.4	0.6	1.0	-0.7	-1.5	-1.3	-1.4
Rest time, locomotor task time 2	1.3	1.5	4.3	2.1	-1.6	-0.3	-0.7	-0.7	-0.9
Distance moved, locomotor task time 2	1.1	1.3	2.3	-1.5	0.5	0.4	1.4	1.3	1.2
Vertical activity count, locomotor time 2	0.7	0.7	3.1	-1.0	1.8	0.1	0.4	0.3	0.0
Light reinforcement 1	0.1	0.2	0.5	-0.1	-0.6	-0.7	-0.2	-0.2	-0.6
Light reinforcement 2	0.9	1.2	2.1	0.3	-1.4	-1.3	-1.2	-1.1	-0.7
Bone: marrow area	0.4	0.8	1.9	1.1	-0.7	1.4	0.8	0.7	-0.0
Bone: maximum diameter	0.9	1.7	2.4	-0.9	-1.6	1.2	1.3	1.3	1.5
Bone: maximum force	0.5	0.9	3.3	-0.3	-1.8	0.7	0.7	0.7	0.8
Bone: maximum moment	0.4	0.7	2.9	-0.0	-1.7	0.7	0.6	0.6	0.6
Mean time between licks in bursts	0.4	0.6	1.2	0.8	-0.7	1.1	0.7	0.7	0.0
Mean num. licks in bursts	0.3	0.4	1.4	0.1	-1.2	-0.8	-0.0	-0.1	0.1
Cd content in liver	2.1	2.3	3.6	0.2	-1.9	1.7	1.7	1.6	1.4
Co content in liver	0.4	0.5	1.2	1.1	0.7	0.1	-0.4	-0.5	-0.9
Cu content in liver	0.8	1.0	1.9	0.3	0.1	-1.3	-1.4	-1.2	-0.9
Fe content in liver	0.4	0.5	2.0	-1.4	0.2	-0.2	0.3	0.4	0.8
K content in liver	4.9	4.8	7.8	1.0	0.4	-2.8	-2.8	-2.8	-2.2
Mg content in liver	3.2	3.3	5.1	1.8	-0.7	-1.9	-2.3	-2.2	-1.7
Mn content in liver	1.0	1.2	2.6	-1.5	1.6	-0.9	-0.8	-0.7	0.2
Na content in liver	6.1	6.5	10.7	0.9	1.1	-3.3	-3.1	-3.2	-2.5
Rb content in liver	0.3	0.4	1.3	0.1	0.4	1.1	0.6	0.6	0.3
Se content in liver	1.8	2.2	3.9	0.2	0.7	-2.0	-1.8	-1.8	-1.4
Sr content in liver	1.9	1.8	2.4	-0.9	-1.2	1.2	1.5	1.5	1.6
Zn content in liver	1.2	1.4	2.4	0.0	1.1	-1.6	-1.3	-1.3	-1.0
Bone: minimum diameter	1.2	2.2	5.6	2.4	-1.9	1.6	0.7	0.5	-0.4
Time in familiar zone, hab. session 1	1.5	1.4	3.2	-0.5	0.3	-1.8	-1.5	-1.5	-0.7
Time in novel zone, hab. session 1	2.3	2.2	5.4	1.6	-0.7	2.3	1.6	1.5	0.2
Total zone transitions, hab. session 1	3.3	4.6	6.0	0.6	2.3	-2.3	-2.5	-2.4	-2.2
Total locomotion distance, hab. session 1	3.6	5.1	7.4	1.2	0.9	-2.7	-2.7	-2.7	-2.5
Locomotion velocity, hab. session 1	3.6	5.1	8.4	0.5	1.2	-2.9	-2.8	-2.8	-2.2
Time in familiar zone, hab. session 2	0.8	0.8	4.0	0.9	-2.0	-0.3	-0.1	-0.2	-0.1
Time in novel zone, hab. session 2	0.8	0.8	3.3	-0.7	1.8	0.8	0.5	0.5	0.1
Total zone transitions, hab. session 2	0.2	0.3	1.0	-0.4	1.0	-0.5	-0.4	-0.4	-0.4
Total locomotion distance, hab. session 2	0.4	0.5	0.9	0.2	0.4	-0.9	-0.7	-0.7	-0.9
Locomotion velocity, hab. session 2	0.9	1.3	2.0	0.3	0.7	-1.4	-1.3	-1.3	-1.3
Novel to familiar place preference ratio	0.3	0.3	0.5	0.2	0.1	-0.5	-0.7	-0.6	-0.6
Novelty place preference	0.3	0.3	0.5	0.4	-0.1	-0.4	-0.7	-0.7	-0.6
Time in novel zone, NPP test	0.4	0.4	0.7	0.6	0.1	-0.5	-0.8	-0.8	-0.8
Total zone transitions, NPP test	0.7	0.9	2.6	-1.6	1.5	-0.6	-0.4	-0.3	0.4
Total locomotion distance, NPP test	0.8	1.0	2.1	-0.6	0.6	-1.4	-1.3	-1.2	-0.6
Locomotion velocity, NPP test	0.8	1.1	1.9	-1.1	0.9	-1.4	-1.1	-1.0	-0.3
Intraocular pressure	0.6	0.8	1.9	0.8	-0.7	1.4	0.9	0.9	0.2
Delta distance traveled before/after self-admin	0.5	0.5	2.4	0.2	1.5	-0.1	-0.5	-0.5	-0.4
Delta ambulatory time before/after self-admin	0.5	0.6	3.1	-0.1	1.8	-0.0	-0.3	-0.3	-0.1
Parametrial fat weight	0.4	0.8	1.3	-0.2	-1.1	1.0	1.0	1.0	0.7
Pavlov. Cond. lever latency	0.7	0.9	1.3	-0.0	-1.0	1.0	1.1	1.0	1.0
Pavlov. Cond. magazine entry latency	0.9	1.2	1.9	0.1	1.1	-1.1	-1.4	-1.3	-1.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	-0.1	0.9	-0.6	-0.5	-0.5	-0.6
Pavlov. Cond. index score	1.5	1.9	2.7	-0.2	1.5	-1.6	-1.6	-1.5	-1.2
Pavlov. Cond. latency score	1.0	1.2	1.8	-0.3	1.2	-1.3	-1.3	-1.2	-1.0
Pavlov. Cond. lever contacts	1.0	1.2	2.6	-0.4	1.6	-1.1	-1.2	-1.0	-0.9
Pavlov. Cond. magazine entry number	1.1	1.4	2.5	0.4	-1.6	1.2	1.4	1.3	1.0
Pavlov. Cond. intertrial magazine entries	0.9	1.1	2.3	0.1	1.5	-1.2	-1.0	-1.1	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.8	-0.3	1.5	-1.7	-1.7	-1.5	-1.3
Pavlov. Cond. response bias	1.4	1.7	2.4	0.1	1.5	-1.2	-1.5	-1.5	-1.3
Pavlov. Cond. lever latency	0.1	0.2	0.9	-0.4	1.0	-0.2	-0.1	-0.1	0.0
Pavlov. Cond. magazine entry latency	0.8	0.9	1.5	0.3	-0.9	1.2	1.2	1.2	0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.8	0.3	-0.9	-0.4	-0.2	-0.3	-0.3
Pavlov. Cond. index score	0.9	1.2	2.7	0.6	-1.6	1.1	1.1	1.1	0.6
Pavlov. Cond. latency score	1.0	1.2	2.7	0.3	-1.7	1.0	1.2	1.2	0.8
Pavlov. Cond. lever contacts	0.4	0.5	1.8	1.0	-1.3	0.2	-0.1	-0.1	-0.3
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	-0.2	1.0	-1.1	-1.2	-1.2	-0.7
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.3	0.6	-0.2	-0.3	-0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	2.3	0.6	-1.5	1.0	1.0	1.0	0.5
Pavlov. Cond. response bias	0.3	0.4	1.2	1.1	-1.0	0.4	0.1	0.1	-0.4
Time in closed arm before self-admin	1.3	1.4	2.7	-1.7	1.4	0.4	1.3	1.3	0.6
Time in closed arm after self-admin	1.1	1.2	3.2	-1.8	1.7	-0.7	-0.3	-0.2	0.4
Time in open arm before self-admin	0.2	0.2	0.5	0.5	-0.7	0.4	0.2	0.1	0.6
Time in open arm after self-admin	1.8	2.0	6.7	2.6	-1.5	0.0	-0.7	-0.8	-1.3
Bone: periosteal estimation	0.4	0.8	1.1	-0.2	-1.0	1.1	0.9	0.9	0.8
Bone: periosteal perimeter	0.2	0.4	1.3	-0.4	-1.1	0.2	0.3	0.3	0.7
Bone: post-yield work	1.4	1.9	6.6	2.0	-2.6	0.8	0.4	0.4	-0.3
Progressive ratio test 1 active lever presses	1.8	1.8	6.3	2.5	-1.6	0.5	-0.1	-0.1	-1.3
Progressive ratio test 1 breakpoint	1.5	1.6	5.5	2.3	-1.6	0.5	-0.1	-0.1	-1.2
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.7	-0.2	-1.3	-1.0	0.0	-0.1	-0.6
Progressive ratio test 2 active lever presses	1.6	1.8	5.9	2.4	-1.7	0.4	-0.1	-0.2	-1.3
Progressive ratio test 2 breakpoint	1.2	1.3	3.6	1.9	-1.7	0.0	-0.3	-0.3	-1.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	1.3	1.1	-1.1	0.1	0.6	0.4	-0.7
Incentive Sensitization - Responses	0.8	0.9	1.7	1.3	-1.1	1.2	0.6	0.6	-0.0
Incentive Sensitization - Breakpoint	0.9	0.9	1.8	1.4	-1.2	1.2	0.6	0.6	-0.1
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.2	0.9	-1.1	-0.3	-0.6	-0.5	-0.1
Progressive ratio	0.1	0.1	0.4	-0.6	-0.5	-0.0	0.1	0.1	0.6
Food seeking constrained by brief footshock	0.3	0.4	0.8	-0.9	0.3	0.1	0.8	0.8	0.6
Seeking ratio, punishment vs. effort	0.0	0.0	0.2	0.4	0.2	0.0	0.1	0.1	-0.1
Retroperitoneal fat weight	0.1	0.3	0.7	0.6	0.8	0.5	-0.3	-0.3	-0.8
Reaction time number correct	0.4	0.5	1.4	-0.1	-0.3	1.2	0.9	0.9	0.4
Reaction time mean minus median	1.0	1.3	3.9	0.6	-2.0	1.2	0.9	1.0	0.6
Reaction time mean minus median AUC	1.4	1.9	5.6	0.7	-2.4	1.3	1.2	1.2	0.7
Reaction time num false alarms	1.8	2.5	4.1	0.8	0.9	-1.7	-2.0	-1.9	-1.7
Reaction time num false alarms AUC	2.0	2.8	4.3	0.7	1.2	-1.8	-2.1	-2.0	-1.9
Reaction time trials correct on left	0.4	0.5	1.4	-0.1	-0.3	1.2	0.9	0.9	0.4
Reaction time trials on left	0.4	0.6	1.5	-0.2	-0.3	1.2	1.0	0.9	0.5
Reaction time mean	1.0	1.4	2.5	0.1	-1.1	1.6	1.3	1.3	1.0
Reaction time mean AUC	0.6	0.9	1.8	0.3	-0.9	1.3	1.0	1.1	0.7
Median of all reaction times	0.6	0.9	2.1	0.1	-0.6	1.4	1.0	1.1	0.8
Reaction time omissions	0.9	1.2	2.1	-1.0	-0.2	1.3	1.1	1.2	1.4
Reaction time false alarm rate	2.5	3.4	5.6	0.9	1.2	-2.1	-2.4	-2.2	-1.9
Reaction time premature initiation rate	0.3	0.4	0.8	0.4	-0.2	-0.9	-0.8	-0.7	-0.5
Reaction time premature initiations	0.1	0.1	0.1	0.3	-0.4	-0.3	-0.3	-0.2	-0.3
Std. dev. reaction times	0.5	0.7	1.2	0.3	-1.1	1.1	0.8	0.9	0.6
Reaction time trials completed	0.4	0.6	1.5	-0.2	-0.3	1.2	1.0	0.9	0.5
Reaction time trials AUC	0.6	0.8	2.0	-0.1	-0.3	1.4	1.1	1.1	0.5
Run reversals in cocaine runway, females	0.1	0.1	0.3	-0.5	0.3	-0.6	-0.1	0.0	0.2
Run reversals in cocaine runway, males	1.5	1.5	2.4	-1.2	-0.1	1.3	1.1	1.4	1.5
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.1	0.7	0.3	-0.3	-0.2	-0.7
Latency to leave start box in cocaine runway, F	0.5	0.5	1.5	0.6	0.4	-0.3	-0.6	-0.7	-1.2
Latency to leave start box in cocaine runway, M	1.5	1.4	3.2	-0.7	-0.1	1.8	1.3	1.4	1.1
Std. dev. time between licks in bursts	0.2	0.3	0.6	0.8	-0.2	-0.1	-0.6	-0.5	-0.6
Total sessions with >9 infusions	0.8	0.9	1.7	0.3	-1.3	0.9	1.1	1.1	0.6
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	-0.1	-0.2	-0.1	-0.1	-0.3
Short access day 10 total inactive lever presses	0.8	0.9	3.3	-1.8	0.9	-1.0	-0.1	-0.1	0.5
Short access day 1 total infusions	0.9	0.9	1.8	1.0	-1.3	-0.4	-1.1	-0.9	-0.8
Short access day 10 total infusions	0.7	0.7	2.8	0.9	-1.7	-0.3	0.2	0.1	-0.8
Short access total infusions	0.8	0.9	4.0	0.8	-2.0	0.5	0.3	0.5	0.0
Short access day 1 locomotion	0.8	0.8	1.9	1.3	-0.4	-0.0	-0.8	-0.7	-1.4
Short access day 10 total locomotion	0.1	0.1	0.4	0.2	-0.1	-0.2	-0.3	-0.4	-0.7
Short access total locomotion	0.3	0.3	0.9	0.6	-0.9	0.3	0.3	0.3	-0.2
One hour access (0.3 mA shock)	1.0	1.1	4.1	2.0	-0.4	0.6	0.1	-0.1	-1.5
Compulsive drug intake	1.0	1.0	3.3	-1.8	1.0	-0.9	-0.5	-0.5	0.7
One hour access (shock baseline)	2.0	2.4	9.5	3.1	-1.3	0.9	0.3	0.2	-1.5
Social response proportion	0.2	0.3	0.9	0.6	-0.9	0.4	0.3	0.2	-0.1
Social responses	0.6	0.8	2.2	0.1	1.5	-0.6	-0.7	-0.8	-1.1
Social time	0.1	0.1	0.4	0.2	0.2	0.5	0.6	0.5	-0.0
Soleus weight	1.5	4.4	7.9	-2.6	2.5	-2.8	-1.6	-1.5	0.1
Bone: stiffness	0.8	1.2	2.0	0.7	-0.4	-1.0	-1.4	-1.4	-1.3
Tibialis anterior weight	0.7	2.5	9.4	-3.1	0.8	-1.8	-0.6	-0.5	1.0
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.3	1.1	0.2	0.9	-0.2	-0.1	-0.4
Time to tail flick, vehicle, after self-admin	1.9	2.1	4.7	-0.3	2.2	-1.3	-1.5	-1.6	-1.1
Time to tail flick, test, before self-admin	0.4	0.4	2.2	-0.4	1.5	-0.4	0.1	0.1	-0.1
Time to tail flick, test, after self-admin	0.3	0.4	0.9	0.9	0.5	0.6	-0.3	-0.2	-0.7
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.8	-1.0	1.2	-1.4	-0.2	-0.4	-0.3
Delta time to tail flick, test, before/after SA	0.7	0.6	1.1	1.0	-0.6	0.1	-1.0	-0.9	-0.7
Tibia length	1.0	2.8	5.8	0.8	-1.1	2.4	2.0	1.9	1.2
Ambulatory time before self-admin	1.3	1.3	3.3	1.8	0.2	-0.3	-0.9	-1.0	-1.6
Ambulatory time after self-admin	2.5	2.7	4.6	2.1	2.0	-0.3	-1.2	-1.4	-2.1
Bone: tissue strength	0.5	0.5	0.8	0.9	-0.3	-0.5	-0.8	-0.7	-0.9
Total heroin consumption	0.7	0.9	1.9	1.4	1.0	0.7	-0.9	-0.7	-0.8
Bone: trabecular number	0.4	0.7	2.3	-1.5	0.1	-1.0	-0.6	-0.5	0.4
Bone: trabecular spacing	0.2	0.2	0.3	0.6	0.1	-0.5	-0.4	-0.4	-0.6
Bone: trabecular thickness	0.3	0.4	1.8	-1.4	0.4	-0.2	-0.0	0.1	0.7
Bone: trabecular tissue density	0.1	0.1	0.5	-0.7	0.5	-0.2	-0.2	-0.2	0.0
Water consumed over 24 hours	0.2	0.2	0.8	0.7	-0.9	0.1	-0.1	-0.1	-0.2
Number of responses in last shaping day	1.6	1.6	2.6	0.1	0.5	-1.6	-1.6	-1.6	-1.4