Hub : Genes

Afm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Afm	0.04	0.03	1.7e-03	0.03	0.02	0.01	0.03	7.1e-04	6.4e-03	2.8e-02	8.2e-04
2	Liver	gene expression	Afm	0.16	0.07	0.0e+00	0.1	0.14	0.15	0.15	9.0e-11	1.8e-15	3.5e-16	3.6e-16
3	Liver	isoform ratio	NM_172320.2	0.15	0.06	0.0e+00	0.16	0.14	0.15	0.15	1.0e-17	1.1e-15	6.3e-16	1.1e-16
4	Liver	isoform ratio	XM_039091644.2	0.14	0.06	0.0e+00	0.16	0.14	0.14	0.15	7.3e-17	1.4e-15	8.5e-16	2.6e-16
5	Liver	mRNA stability	Afm	0.36	0.1	0.0e+00	0.36	0.36	0.37	0.37	2.3e-42	2.1e-42	1.2e-42	6.2e-43

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.4	0.7	3.2	-0.1	-1.8	-0.4	0.4	-0.1
Area under the delay curve	2.1	2.4	3.8	1.5	0.5	2.0	-2.0	-1.3
BMI with tail	0.8	2.7	11.7	0.8	-3.4	0.4	-0.4	-0.9
BMI without tail	0.2	0.6	2.6	-0.1	-1.6	-0.2	0.2	0.4
Body weight	0.2	0.8	1.3	0.1	-0.7	-1.1	1.1	0.9
Weight adjusted by age	0.1	0.2	0.7	-0.4	-0.1	-0.2	0.2	0.8
Bone surface	0.8	1.4	1.9	-0.5	-1.3	-1.4	1.4	1.2
Bone volume	0.3	0.5	1.3	0.0	-1.2	-0.7	0.7	0.4
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.3	-0.2	0.1	-0.1	0.4
Number of licking bursts	0.1	0.2	0.7	0.8	0.5	0.2	-0.2	0.1
Context. condit. distance diff. score	2.3	2.8	4.1	1.5	-0.7	1.9	-1.9	-2.0
Locomotion velocity, session 1	0.9	1.0	2.9	1.7	-0.6	0.7	-0.7	-0.9
Locomotion distance, session 1	1.8	2.2	2.8	1.5	-0.7	1.6	-1.6	-1.7
Locomotion velocity, session 2	1.2	1.4	5.8	2.4	-0.9	0.1	-0.1	-0.5
Locomotion distance, session 2	1.5	2.1	2.8	1.7	0.1	1.6	-1.6	-1.5
Locomotion velocity, session 3	0.8	0.9	1.9	0.5	-0.3	1.1	-1.1	-1.4
Locomotion distance, session 3	1.8	1.9	3.0	1.7	-1.1	1.3	-1.3	-1.4
Stereotopy head waving bouts, day 3	0.5	0.6	0.9	0.8	0.5	0.9	-0.9	-0.8
Stereotopy head waving duration, day 3	0.6	0.8	1.0	-0.7	0.7	1.0	-1.0	-0.9
Locomotion velocity, session 7	1.7	1.8	3.5	-0.2	0.6	1.9	-1.9	-1.3
Locomotion distance, session 7	0.9	1.2	2.3	-0.6	0.5	1.5	-1.5	-0.9
Stereotopy head waving bouts, day 7	0.3	0.4	1.0	0.9	-1.0	-0.3	0.3	0.2
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.4	-0.3	-0.2	0.2	0.0
Locomotion velocity, session 8	2.7	3.3	5.4	1.0	-1.1	2.1	-2.1	-2.3
Locomotion distance, session 8	3.1	4.5	5.9	2.0	-1.2	2.4	-2.4	-2.4
Degree of sensitization distance	0.8	0.9	2.5	-1.6	1.1	-0.3	0.3	0.6
Degree of sensitization stereotypy	0.2	0.2	0.2	0.5	-0.5	-0.4	0.4	0.2
Conditioned locomotion	1.3	1.5	6.5	-2.6	0.8	-0.2	0.2	-0.1
Cocaine response after cond. corrected	0.1	0.2	0.4	-0.6	0.4	-0.3	0.3	0.3
Cocaine response after cond. not corrected	0.4	0.5	0.7	-0.3	-0.6	-0.9	0.9	0.7
Cocaine response before conditioning	1.4	1.7	4.5	0.5	-2.1	-1.2	1.2	1.0
Saline control response	0.1	0.1	0.6	-0.0	-0.8	-0.2	0.2	0.0
Bone: connectivity density	0.4	0.6	2.7	-0.3	-1.6	0.0	-0.0	-0.3
Bone: cortical apparent density	0.4	0.6	2.0	1.4	0.0	0.4	-0.4	-0.8
Bone: cortical area	0.3	0.5	1.9	-0.6	-1.4	-0.2	0.2	0.5
Bone: cortical porosity	0.4	0.4	1.4	-1.2	0.3	0.4	-0.4	-0.3
Bone: cortical porosity	0.4	0.5	2.2	-1.5	-0.0	-0.1	0.1	0.2
Bone: cortical thickness	0.7	1.1	5.5	0.2	-2.4	-0.1	0.1	0.1
Bone: cortical thickness	0.7	0.8	1.2	-0.5	-1.1	-1.0	1.0	1.0
Bone: cortical tissue density	0.5	0.6	2.4	1.5	-0.0	0.4	-0.4	-0.7
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.7	0.5	-0.3	0.3	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.5	0.9	-0.1	0.1	0.5
Condit. Reinf. active responses	0.2	0.2	0.9	0.9	0.2	0.1	-0.1	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.5	0.3	-0.7	-0.1	0.1	-0.2
Incentive salience index mean	0.1	0.1	0.3	0.5	0.1	0.3	-0.3	-0.3
Condit. Reinf. lever presses	0.0	0.1	0.2	-0.4	-0.4	0.0	-0.0	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.9	3.4	1.8	-1.0	0.2	-0.2	-0.2
Condit. Reinf. active-inactive response ratio	1.2	1.4	2.3	-0.1	-0.5	-1.5	1.5	1.5
Condit. Reinf. active responses	1.0	1.4	4.6	2.1	-0.4	0.8	-0.8	-0.8
Condit. Reinf. inactive responses	1.2	1.5	2.3	1.5	0.2	1.4	-1.4	-1.3
Condit. Reinf. lever presses	0.1	0.2	0.3	0.1	0.6	0.5	-0.5	-0.4
Condit. Reinf. lever reinforcers received	1.1	1.5	4.9	2.2	-0.4	0.9	-0.9	-0.9
Conditioned reinforcement - actives	0.1	0.2	0.3	0.5	0.4	0.4	-0.4	-0.5
Conditioned reinforcement - inactives	0.7	1.0	1.5	-1.2	0.2	-1.2	1.2	0.8
Conditioned locomotion	0.8	1.0	4.1	-0.8	2.0	0.2	-0.2	-0.5
Patch foraging indifference point 0 sec	0.2	0.3	0.8	0.7	-0.5	0.2	-0.2	-0.9
Patch foraging indifference point AUC	0.7	1.0	2.4	-1.6	0.8	0.9	-0.9	-0.5
Delay disc. indifference point, 0s delay	0.5	0.6	1.3	1.1	-0.2	0.8	-0.8	-0.6
Delay disc. indifference point, 16s delay	1.1	1.2	2.1	1.5	-0.2	1.3	-1.3	-0.9
Delay disc. indifference point, 2s delay	1.1	1.3	1.9	0.2	1.2	1.4	-1.4	-1.1
Delay disc. indifference point, 24s delay	2.0	2.2	3.2	0.4	1.7	1.8	-1.8	-1.2
Delay disc. indifference point, 4s delay	3.4	3.6	5.4	1.6	0.3	2.3	-2.3	-2.1
Delay disc. indifference point, 8s delay	0.8	0.9	1.7	1.3	0.0	1.1	-1.1	-0.5
Indifference point function ln k	0.7	1.2	3.2	1.8	-1.3	-0.7	0.7	0.5
Indifference point function log k	0.7	1.2	3.2	1.8	-1.3	-0.7	0.7	0.5
Patch foraging total patch changes 0 sec	0.1	0.3	0.9	0.4	-0.3	0.3	-0.3	-1.0
Patch foraging total patch changes 12 sec	1.1	1.5	2.5	0.5	0.4	1.5	-1.5	-1.6
Patch foraging total patch changes 18 sec	0.0	0.1	0.1	0.2	0.2	-0.3	0.3	0.0
Patch foraging total patch changes 24 sec	1.3	2.2	3.9	0.8	0.7	1.7	-1.7	-2.0
Patch foraging total patch changes 6 sec	1.0	1.5	2.9	-0.3	0.5	1.4	-1.4	-1.7
Patch foraging time to switch 0 sec	0.2	0.4	0.6	0.7	-0.8	-0.6	0.6	0.6
Patch foraging water rate 0 sec	0.2	0.5	1.7	-1.3	0.7	-0.2	0.2	-0.2
Patch foraging water rate 12 sec	0.5	1.0	1.3	-0.9	0.7	1.2	-1.2	-1.0
Patch foraging water rate 18 sec	0.3	0.5	1.1	1.0	0.3	0.5	-0.5	-0.7
Patch foraging water rate 24 sec	0.3	0.4	0.6	0.1	0.6	-0.8	0.8	0.5
Patch foraging water rate 6 sec	0.7	1.1	1.5	0.1	1.2	1.1	-1.1	-1.1
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.6	0.3	0.8	0.8	-0.8	-0.7
Distance traveled before self-admin	0.7	0.9	3.0	-0.7	1.7	0.6	-0.6	-0.3
Distance traveled after self-admin	2.1	2.6	6.7	0.9	2.6	1.4	-1.4	-1.3
Extensor digitorum longus weight	2.7	10.5	42.0	1.4	-6.5	-1.9	1.9	1.2
Bone: elastic displacement	0.6	0.7	3.2	0.2	-1.8	-0.3	0.3	0.5
Bone: elastic work	1.1	1.4	4.9	0.5	-2.2	-0.7	0.7	0.9
Bone: endosteal estimation	0.3	0.7	1.8	-0.1	1.4	-0.6	0.6	0.9
Bone: endosteal perimeter	0.4	0.8	1.4	-1.1	0.5	-0.7	0.7	1.2
Epididymis fat weight	0.5	1.7	2.6	0.9	1.3	1.6	-1.6	-0.9
Delta time in closed arm before/after self-admin	0.3	0.2	0.3	0.4	-0.2	0.6	-0.6	-0.6
Delta time in open arm before/after self-admin	0.4	0.4	0.9	-0.9	1.0	0.3	-0.3	-0.1
Diff in mean of infusions in LGA sessions	1.0	1.2	2.6	-0.0	-0.3	-1.3	1.3	1.6
Delay discount exponential model param	2.3	2.6	4.4	-1.3	-0.7	-2.1	2.1	1.4
Extinction: sum of active levers before priming	0.5	0.6	1.4	-0.6	1.2	0.6	-0.6	-0.6
Active lever presses in extinction session 6	0.4	0.4	2.0	-0.3	1.4	-0.1	0.1	0.3
Bone: final force	0.3	0.4	0.6	-0.6	0.2	-0.7	0.7	0.8
Bone: final moment	0.2	0.3	0.5	-0.5	0.4	-0.6	0.6	0.7
Food consumed during 24 hour testing period	0.2	0.2	0.4	0.0	-0.6	0.6	-0.6	-0.2
Glucose	0.4	0.6	1.3	0.6	1.1	0.7	-0.7	-0.4
Heart weight	0.5	0.8	1.2	-0.2	-1.0	-0.9	0.9	1.1
Delay discount hyperbolic model param	2.6	2.9	5.0	-1.2	-0.7	-2.2	2.2	1.6
Intermittent access intake day 1-15 change	0.3	0.7	1.7	1.3	0.1	-0.9	0.9	0.2
Intermittent access intake escalation	0.3	0.6	1.6	1.3	0.0	-0.9	0.9	0.3
Intermittent access intake escalation 2	0.4	0.5	1.8	0.1	1.3	-0.3	0.3	-0.4
Intermitt. access day 1 inactive lever presses	0.3	1.2	2.5	1.3	-1.6	0.6	-0.6	-1.2
Intermitt. access day 15 inactive lever presses	0.7	1.5	3.0	-1.7	-0.0	-1.2	1.2	1.2
Intermitt. access escalation Index	0.8	1.1	1.9	0.3	-0.0	-1.4	1.4	1.3
Intermittent access day 1 total infusions	0.1	0.2	0.9	-0.9	0.3	-0.3	0.3	0.1
Intermittent access day 15 total infusions	0.2	0.3	0.8	-0.3	0.9	-0.4	0.4	-0.3
Intermittent access terminal intake (last 3 days)	0.6	0.8	2.4	-1.0	1.6	-0.0	0.0	-0.7
Intermittent access total infusions	0.5	0.6	1.6	-1.3	0.9	-0.4	0.4	-0.2
Intermittent access day 1 locomotion	0.3	0.3	0.6	-0.7	0.1	-0.8	0.8	0.2
Intermittent access day 15 total locomotion	0.7	1.4	2.6	0.6	1.0	1.2	-1.2	-1.6
Intermittent access total locomotion	0.4	0.5	1.1	-0.6	1.1	-0.7	0.7	-0.1
Intermittent access standard deviation	0.1	0.2	0.5	-0.5	0.1	-0.2	0.2	-0.7
Left kidney weight	0.3	1.5	2.1	-1.5	-0.7	-1.2	1.2	1.3
Right kidney weight	0.7	3.3	6.0	-2.5	0.5	-1.8	1.8	1.9
Cocaine induced anxiety	2.4	3.4	6.6	-0.6	0.1	-2.3	2.3	2.6
Post-drug Anxiety	1.3	1.4	3.2	0.3	-0.4	-1.3	1.3	1.8
Baseline Anxiety	2.6	3.0	4.5	1.6	-0.1	2.1	-2.1	-1.8
Tail length	0.9	3.6	14.7	-1.5	3.8	-0.3	0.3	1.0
Length with tail	1.2	5.3	14.5	-1.4	3.8	-1.7	1.7	2.1
Length without tail	0.4	1.4	2.1	0.3	1.1	-1.5	1.5	1.0
Times rat made contact with spout	0.7	0.8	3.8	-1.9	0.3	-0.1	0.1	0.3
Lifetime Intake	0.7	0.9	3.4	-1.8	0.8	-0.5	0.5	0.0
Liver weight, left	0.6	0.9	2.1	-0.5	1.5	0.7	-0.7	-1.1
Liver weight, right	1.7	3.0	4.1	-0.1	1.9	1.9	-1.9	-2.0
Locomotor activity	0.2	0.3	0.5	0.5	0.4	0.5	-0.5	-0.7
Locomotor testing distance	0.4	0.8	1.8	1.3	-0.0	0.8	-0.8	-0.9
Locomotor testing rearing	0.3	0.5	1.4	1.2	-0.4	0.6	-0.6	-0.7
Locomotion in novel chamber	1.1	1.4	2.3	1.5	0.7	1.3	-1.3	-1.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.2	0.2	0.3	-0.3	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.5	1.4	-1.2	0.3	-0.0	0.0	0.9
Change in fecal boli incidents, locomotor task	0.5	0.5	0.9	-0.2	0.2	-0.9	0.9	0.9
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.4	-1.5	-0.0	-1.5	1.5	1.4
Bouts of movement, locomotor time 1	0.1	0.2	0.5	-0.2	0.7	0.3	-0.3	-0.3
Total resting periods, locomotor time 1	0.3	0.4	1.3	-0.4	1.1	0.5	-0.5	-0.2
Rest time, locomotor task time 1	0.3	0.4	1.1	-0.5	1.1	-0.5	0.5	0.4
Distance moved, locomotor task time 1	0.2	0.3	1.2	-1.1	-0.1	-0.5	0.5	0.0
Vertical activity count, locomotor time 1	0.1	0.2	0.5	0.5	0.4	0.4	-0.4	-0.7
Time >=10cm from walls, locomotor time 2	0.8	1.2	1.6	-0.9	-0.7	-1.3	1.3	1.3
Bouts of movement, locomotor time 2	1.5	2.5	4.1	1.1	0.9	2.0	-2.0	-1.5
Total resting periods, locomotor time 2	1.0	1.8	3.0	0.9	0.8	1.7	-1.7	-1.3
Rest time, locomotor task time 2	1.2	1.6	3.8	-1.9	1.8	0.5	-0.5	-0.6
Distance moved, locomotor task time 2	1.1	1.3	1.9	0.8	-1.4	-1.3	1.3	0.7
Vertical activity count, locomotor time 2	0.7	1.0	4.1	2.0	-0.7	-0.4	0.4	0.1
Light reinforcement 1	0.1	0.1	0.5	-0.3	-0.0	0.0	-0.0	-0.7
Light reinforcement 2	0.8	1.3	4.0	-2.0	0.3	0.8	-0.8	-1.0
Bone: marrow area	0.3	0.6	1.5	-0.0	1.2	-0.6	0.6	0.8
Bone: maximum diameter	0.6	1.2	1.9	-0.8	-0.8	-1.2	1.2	1.4
Bone: maximum force	0.3	0.5	1.4	-1.2	-0.0	-0.5	0.5	0.6
Bone: maximum moment	0.2	0.4	1.2	-1.1	0.3	-0.4	0.4	0.6
Mean time between licks in bursts	0.2	0.5	0.7	-0.2	0.8	-0.7	0.7	0.7
Mean num. licks in bursts	0.5	0.8	4.1	-2.0	-0.0	0.0	-0.0	-0.2
Cd content in liver	3.1	3.5	5.2	-0.2	-1.6	-2.2	2.2	2.3
Co content in liver	0.4	0.5	0.9	0.9	0.1	-0.7	0.7	0.8
Cu content in liver	0.1	0.1	0.4	-0.7	0.2	0.2	-0.2	-0.4
Fe content in liver	1.1	1.3	2.1	-0.9	-0.5	-1.4	1.4	1.2
K content in liver	2.2	2.1	3.5	-0.5	0.9	1.9	-1.9	-1.6
Mg content in liver	1.2	1.2	2.4	-1.5	1.3	1.0	-1.0	-0.5
Mn content in liver	0.6	0.6	1.5	1.1	-1.2	0.4	-0.4	0.0
Na content in liver	3.4	3.6	5.9	-0.4	0.8	2.4	-2.4	-2.4
Rb content in liver	0.4	0.5	1.0	0.3	0.3	-0.8	0.8	1.0
Se content in liver	0.8	0.9	1.6	-0.2	0.5	1.3	-1.3	-1.0
Sr content in liver	2.4	2.1	3.0	-0.5	-1.6	-1.7	1.7	1.2
Zn content in liver	0.1	0.1	0.2	-0.3	-0.1	0.5	-0.5	-0.4
Bone: minimum diameter	1.0	1.8	5.8	-1.7	2.4	0.1	-0.1	0.5
Time in familiar zone, hab. session 1	1.5	1.5	2.4	-0.5	-0.7	1.5	-1.5	-1.4
Time in novel zone, hab. session 1	2.2	2.2	3.5	-0.0	1.9	-1.7	1.7	1.5
Total zone transitions, hab. session 1	3.4	4.8	6.9	1.9	0.6	2.6	-2.6	-2.5
Total locomotion distance, hab. session 1	3.1	4.4	7.0	-0.6	1.1	2.6	-2.6	-2.6
Locomotion velocity, hab. session 1	3.0	4.3	7.1	-0.2	0.5	2.7	-2.7	-2.6
Time in familiar zone, hab. session 2	1.6	1.7	8.1	-2.9	0.6	0.0	-0.0	0.1
Time in novel zone, hab. session 2	1.8	1.8	8.5	2.9	-0.4	-0.3	0.3	0.3
Total zone transitions, hab. session 2	0.4	0.5	1.1	1.0	-0.5	0.6	-0.6	-0.5
Total locomotion distance, hab. session 2	0.3	0.4	0.7	0.0	0.1	0.8	-0.8	-0.8
Locomotion velocity, hab. session 2	0.8	1.1	1.8	0.2	0.2	1.4	-1.4	-1.3
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.5	0.3	0.4	-0.4	-0.7
Novelty place preference	0.3	0.3	0.7	-0.8	0.5	0.4	-0.4	-0.7
Time in novel zone, NPP test	0.4	0.4	0.6	-0.6	0.7	0.5	-0.5	-0.8
Total zone transitions, NPP test	0.8	1.2	3.1	1.8	-1.6	0.2	-0.2	-0.3
Total locomotion distance, NPP test	0.5	0.6	1.0	-0.3	-0.7	0.8	-0.8	-1.0
Locomotion velocity, NPP test	0.5	0.6	1.6	0.0	-1.3	0.7	-0.7	-0.9
Intraocular pressure	0.4	0.6	0.7	-0.7	0.8	-0.8	0.8	0.7
Delta distance traveled before/after self-admin	1.2	1.3	3.1	1.8	0.6	1.1	-1.1	-0.8
Delta ambulatory time before/after self-admin	1.1	1.4	4.7	2.2	0.3	0.9	-0.9	-0.6
Parametrial fat weight	0.1	0.3	0.4	-0.2	0.6	-0.6	0.6	0.4
Pavlov. Cond. lever latency	0.9	1.1	1.5	-1.2	-0.3	-1.2	1.2	1.2
Pavlov. Cond. magazine entry latency	0.9	1.2	1.7	1.3	-0.1	1.3	-1.3	-0.9
Pavlov. Cond. change in total contacts	0.7	0.7	2.1	1.5	0.0	0.8	-0.8	-0.7
Pavlov. Cond. index score	1.7	2.2	2.9	1.7	0.0	1.7	-1.7	-1.5
Pavlov. Cond. latency score	1.1	1.4	1.9	1.3	0.0	1.4	-1.4	-1.2
Pavlov. Cond. lever contacts	1.1	1.3	3.1	1.8	-0.1	1.1	-1.1	-1.1
Pavlov. Cond. magazine entry number	1.4	1.8	3.4	-1.8	0.1	-1.5	1.5	1.1
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.4	0.6	0.2	0.9	-0.9	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.3	3.2	1.8	-0.0	1.7	-1.7	-1.5
Pavlov. Cond. response bias	1.8	2.2	3.1	1.7	0.3	1.8	-1.8	-1.4
Pavlov. Cond. lever latency	0.2	0.3	1.4	1.2	-0.3	-0.2	0.2	0.0
Pavlov. Cond. magazine entry latency	0.6	0.7	1.2	-0.9	0.3	-0.9	0.9	1.1
Pavlov. Cond. change in total contacts	0.2	0.3	0.7	-0.8	0.0	0.6	-0.6	-0.3
Pavlov. Cond. index score	0.5	0.6	1.8	-1.3	0.4	-0.6	0.6	0.8
Pavlov. Cond. latency score	0.6	0.8	2.1	-1.5	0.1	-0.7	0.7	1.0
Pavlov. Cond. lever contacts	0.4	0.5	2.0	-1.4	0.7	0.3	-0.3	0.0
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	0.8	-0.1	0.9	-0.9	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.2	0.4	0.2	0.2	-0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.7	-1.3	0.4	-0.5	0.5	0.8
Pavlov. Cond. response bias	0.2	0.3	0.7	-0.7	0.9	0.2	-0.2	0.1
Time in closed arm before self-admin	1.7	2.1	3.3	1.0	-1.3	-1.8	1.8	1.2
Time in closed arm after self-admin	1.1	1.2	3.3	1.8	-1.5	-0.0	0.0	-0.3
Time in open arm before self-admin	0.5	0.6	1.6	-0.5	1.3	0.7	-0.7	-0.2
Time in open arm after self-admin	2.3	2.6	7.1	-1.7	2.7	1.1	-1.1	-0.6
Bone: periosteal estimation	0.2	0.4	0.9	-0.3	0.0	-0.6	0.6	1.0
Bone: periosteal perimeter	0.1	0.2	0.8	-0.9	-0.3	-0.1	0.1	0.4
Bone: post-yield work	1.6	2.4	7.6	-2.7	1.6	-0.8	0.8	0.7
Progressive ratio test 1 active lever presses	1.4	1.7	4.4	-2.1	2.0	-0.3	0.3	-0.2
Progressive ratio test 1 breakpoint	1.4	1.7	4.3	-2.1	2.0	-0.3	0.3	-0.2
Progressive ratio test 1 inactive lever presses	0.5	0.8	2.8	-1.7	-0.3	-0.7	0.7	0.0
Progressive ratio test 2 active lever presses	1.6	1.8	5.6	-2.4	1.9	0.1	-0.1	-0.3
Progressive ratio test 2 breakpoint	1.5	1.7	5.2	-2.3	1.8	0.2	-0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.7	1.2	4.1	-2.0	1.1	-0.6	0.6	0.1
Incentive Sensitization - Responses	0.3	0.4	1.2	-0.7	1.1	-0.3	0.3	0.3
Incentive Sensitization - Breakpoint	0.3	0.4	1.1	-0.8	1.1	-0.3	0.3	0.3
Sum of active levers in priming session hrs 5-6	0.9	0.8	2.6	-1.6	0.7	0.7	-0.7	-0.4
Progressive ratio	0.1	0.1	0.6	-0.8	-0.3	-0.1	0.1	-0.1
Food seeking constrained by brief footshock	0.6	0.7	1.1	0.7	-1.1	-0.9	0.9	0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	0.4	0.1	-0.1	0.0
Retroperitoneal fat weight	0.2	0.8	1.0	0.9	0.7	-1.0	1.0	0.7
Reaction time number correct	0.1	0.2	0.6	0.4	0.2	-0.4	0.4	0.8
Reaction time mean minus median	0.5	1.1	3.0	-1.7	0.3	-0.9	0.9	0.9
Reaction time mean minus median AUC	0.5	1.4	3.4	-1.9	0.4	-1.0	1.0	1.0
Reaction time num false alarms	1.5	2.1	3.1	1.0	0.6	1.8	-1.8	-1.6
Reaction time num false alarms AUC	1.4	2.2	3.1	1.3	0.6	1.8	-1.8	-1.7
Reaction time trials correct on left	0.1	0.2	0.6	0.4	0.2	-0.4	0.4	0.8
Reaction time trials on left	0.1	0.3	0.7	0.4	0.1	-0.5	0.5	0.8
Reaction time mean	0.7	1.1	2.0	-1.1	0.0	-1.1	1.1	1.4
Reaction time mean AUC	0.5	0.8	1.3	-1.0	0.2	-0.8	0.8	1.2
Median of all reaction times	0.5	0.7	1.9	-0.6	-0.1	-0.9	0.9	1.4
Reaction time omissions	0.9	1.3	2.1	0.0	-1.0	-1.3	1.3	1.4
Reaction time false alarm rate	1.7	2.4	3.6	1.0	0.6	1.9	-1.9	-1.8
Reaction time premature initiation rate	0.3	0.4	0.7	0.3	0.4	0.9	-0.9	-0.5
Reaction time premature initiations	0.1	0.2	0.3	0.4	0.4	0.5	-0.5	-0.2
Std. dev. reaction times	0.3	0.6	1.0	-1.0	0.2	-0.7	0.7	0.9
Reaction time trials completed	0.1	0.3	0.7	0.4	0.1	-0.5	0.5	0.8
Reaction time trials AUC	0.2	0.4	1.0	0.5	0.1	-0.6	0.6	1.0
Run reversals in cocaine runway, females	0.2	0.2	0.7	0.8	-0.2	0.1	-0.1	-0.5
Run reversals in cocaine runway, males	1.4	1.4	2.3	0.6	-1.3	-1.2	1.2	1.5
Latency to leave start box in cocaine runway	0.2	0.2	0.3	0.5	0.4	0.4	-0.4	-0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	1.4	0.1	0.8	0.9	-0.9	-1.2
Latency to leave start box in cocaine runway, M	0.6	0.6	0.8	0.9	-0.5	-0.7	0.7	0.9
Std. dev. time between licks in bursts	0.2	0.3	0.4	-0.6	0.6	0.5	-0.5	-0.3
Total sessions with >9 infusions	1.0	1.2	4.9	-2.2	0.8	-0.3	0.3	0.3
Short access day 1 total inactive lever presses	0.5	0.7	0.8	-0.7	0.9	0.9	-0.9	-0.7
Short access day 10 total inactive lever presses	0.4	1.1	3.6	1.3	-1.9	-0.2	0.2	0.1
Short access day 1 total infusions	1.7	2.3	3.3	-1.8	0.9	1.6	-1.6	-1.3
Short access day 10 total infusions	1.1	1.4	4.7	-2.2	0.8	0.5	-0.5	-1.0
Short access total infusions	0.7	0.9	4.4	-2.1	0.3	-0.2	0.2	0.1
Short access day 1 locomotion	1.4	1.7	3.2	-0.9	1.8	1.3	-1.3	-1.0
Short access day 10 total locomotion	0.2	0.4	0.9	-1.0	0.5	0.4	-0.4	-0.8
Short access total locomotion	0.8	1.0	3.4	-1.8	1.1	-0.2	0.2	-0.4
One hour access (0.3 mA shock)	0.8	0.9	3.6	-0.5	1.9	-0.4	0.4	-0.2
Compulsive drug intake	0.9	1.1	3.9	1.2	-2.0	-0.2	0.2	0.1
One hour access (shock baseline)	1.3	2.0	7.1	-1.4	2.7	0.4	-0.4	-0.7
Social response proportion	0.7	0.8	3.6	-1.9	0.5	-0.4	0.4	0.3
Social responses	0.5	0.7	1.7	1.3	0.2	0.6	-0.6	-1.0
Social time	0.2	0.3	0.7	0.0	0.3	-0.9	0.9	0.1
Soleus weight	1.6	4.6	8.0	2.6	-2.8	1.5	-1.5	-1.8
Bone: stiffness	0.7	1.1	1.6	-0.5	1.0	1.1	-1.1	-1.3
Tibialis anterior weight	0.7	2.3	10.2	0.9	-3.2	0.1	-0.1	-0.7
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.2	0.2	1.1	0.3	-0.3	0.0
Time to tail flick, vehicle, after self-admin	0.8	1.1	3.1	1.8	-0.3	0.5	-0.5	-1.3
Time to tail flick, test, before self-admin	1.1	1.2	1.5	1.2	-0.6	-1.2	1.2	1.1
Time to tail flick, test, after self-admin	0.3	0.3	1.4	0.2	1.2	0.0	-0.0	0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	1.1	0.8	-1.0	-0.4	0.4	-0.7
Delta time to tail flick, test, before/after SA	1.2	1.2	1.5	-0.9	1.2	1.2	-1.2	-0.9
Tibia length	0.7	2.0	3.7	-0.5	0.9	-1.6	1.6	1.9
Ambulatory time before self-admin	0.5	0.7	2.0	-0.5	1.4	0.7	-0.7	-0.7
Ambulatory time after self-admin	2.2	2.6	3.7	1.7	1.9	1.5	-1.5	-1.4
Bone: tissue strength	0.4	0.4	0.6	-0.8	0.6	0.6	-0.6	-0.6
Total heroin consumption	0.9	1.0	2.7	1.2	1.6	0.7	-0.7	0.1
Bone: trabecular number	0.3	0.4	1.7	-0.1	-1.3	0.0	-0.0	-0.6
Bone: trabecular spacing	0.2	0.2	0.4	0.0	0.6	0.6	-0.6	-0.4
Bone: trabecular thickness	0.4	0.5	2.0	0.5	-1.4	0.1	-0.1	-0.2
Bone: trabecular tissue density	0.2	0.3	0.5	0.4	-0.7	-0.7	0.7	-0.1
Water consumed over 24 hours	0.1	0.2	0.8	-0.9	-0.1	0.1	-0.1	0.2
Number of responses in last shaping day	2.5	2.8	4.8	0.5	0.6	2.2	-2.2	-1.9