Hub : Genes

Afap1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IL gene expression Afap1 0.55 0.17 1.3e-09 0.31 0.36 0.35 0.32 4.1e-08 1.2e-09 3.6e-09 2.1e-08
2 OFC gene expression Afap1 0.25 0.12 8.9e-05 0.13 0.15 0.09 0.14 4.8e-04 2.3e-04 3.5e-03 3.7e-04
3 Brain gene expression Afap1 0.04 0.03 2.3e-03 0.01 0.03 0.02 0.02 6.6e-02 1.2e-03 3.0e-03 4.9e-03
4 IC gene expression Afap1 0.2 0.1 5.3e-06 0.13 0.14 0.13 0.11 3.1e-06 2.2e-06 5.3e-06 2.9e-05
5 PL gene expression Afap1 0.21 0.1 0.0e+00 0.18 0.2 0.2 0.2 8.7e-19 5.1e-21 3.8e-21 2.2e-21
6 Brain isoform ratio XM_017599057.3 0.04 0.03 5.6e-04 0.01 0.03 0.02 0.02 7.5e-02 1.9e-03 6.0e-03 1.1e-02
7 Brain alternative polyA XM_008770245.4 0.04 0.02 1.7e-03 0.01 0.02 0.01 0.01 7.6e-02 4.5e-03 1.2e-02 2.2e-02
8 Brain alternative polyA XM_008770245.4 0.04 0.03 1.3e-03 0.01 0.02 0.02 0.01 7.1e-02 4.2e-03 9.1e-03 1.7e-02
9 PL mRNA stability Afap1 0.05 0.03 1.0e-06 0.05 0.06 0.06 0.06 1.3e-06 7.0e-07 6.9e-07 1.0e-06
10 BLA mRNA stability Afap1 0.09 0.05 3.9e-05 0.07 0.09 0.04 0.07 1.8e-04 2.1e-05 4.4e-03 2.0e-04
11 Adipose alternative polyA XM_008770245.4 0.03 0.02 1.2e-04 0.02 0.02 0.01 0.01 6.5e-03 6.6e-03 4.0e-02 1.9e-02
12 Brain alternative polyA XM_063272812.1 0.04 0.03 1.1e-04 0.03 0.04 0.04 0.04 4.8e-04 1.7e-04 2.3e-04 1.8e-04
13 NAcc alternative polyA XM_063272812.1 0.03 0.02 1.2e-03 0.03 0.02 0.02 0.02 6.8e-05 1.4e-03 4.8e-04 4.6e-04
14 NAcc alternative polyA XM_063272812.1 0.03 0.02 2.3e-03 0.02 0.01 0.01 0.02 1.5e-04 3.7e-03 1.8e-03 9.9e-04
15 Adipose isoform ratio XM_008770245.4 0.03 0.02 5.1e-04 0.03 0.01 0.01 0.01 8.0e-04 1.2e-02 1.3e-02 8.6e-03
16 IL mRNA stability Afap1 0.2 0.1 1.8e-04 0.15 0.15 0.13 0.13 2.0e-04 2.2e-04 5.9e-04 5.6e-04
17 Adipose alternative polyA XM_008770245.4 0.03 0.02 1.3e-04 0.01 0.01 0.01 0.01 7.0e-03 6.9e-03 4.3e-02 2.0e-02
18 Brain mRNA stability Afap1 0.09 0.05 1.6e-07 0.07 0.07 0.07 0.07 2.4e-07 4.7e-07 7.9e-07 3.6e-07
19 Brain alternative polyA XM_063272812.1 0.05 0.03 2.9e-05 0.04 0.04 0.04 0.04 2.0e-04 6.3e-05 9.6e-05 6.2e-05
20 Adipose isoform ratio XM_063272815.1 0.02 0.02 2.2e-03 0.01 0.01 0 0 6.6e-02 2.4e-02 9.7e-02 9.6e-02
21 NAcc mRNA stability Afap1 0.02 0.01 2.2e-03 0.01 0.02 0.01 0.02 2.0e-03 1.2e-03 2.9e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density1.62.85.3-0.40.30.6-1.1-0.31.11.11.1-1.8-1.81.9-1.8-1.9-1.92.1-2.22.1-2.1-2.1-2.2-2.3
Area under the delay curve0.50.51.61.00.80.60.80.80.70.80.8-0.8-0.61.3-0.5-0.8-0.80.7-0.70.5-0.8-0.4-0.3-0.3
BMI with tail0.72.54.82.22.11.91.81.81.91.91.9-1.2-1.51.6-1.5-1.2-1.21.6-1.51.1-1.6-1.1-0.6-0.8
BMI without tail0.10.41.31.11.00.81.10.90.70.70.6-0.0-0.30.3-0.3-0.2-0.20.4-0.30.0-0.3-0.10.30.1
Body weight1.88.028.75.34.84.25.44.93.43.43.3-1.7-1.70.6-1.7-0.2-0.20.3-0.20.5-0.4-0.20.61.0
Weight adjusted by age1.32.06.62.62.32.02.62.11.71.71.6-1.1-0.90.8-0.9-0.7-0.70.7-0.40.4-0.7-0.30.20.2
Bone surface0.91.62.51.41.51.51.21.41.51.51.5-1.6-1.31.1-1.3-1.3-1.31.1-1.11.1-1.1-0.9-0.9-0.7
Bone volume1.01.72.50.50.91.00.10.51.31.31.3-1.5-1.51.5-1.5-1.6-1.61.5-1.61.5-1.6-1.4-1.5-1.4
Breakpoint value in progressive ratio session0.10.10.3-0.5-0.6-0.6-0.4-0.3-0.5-0.5-0.50.30.4-0.00.40.10.1-0.30.4-0.30.30.30.20.2
Number of licking bursts2.03.35.41.82.12.31.21.92.32.32.3-2.1-2.21.2-2.1-1.4-1.41.5-1.31.9-1.3-1.8-1.7-1.3
Context. condit. distance diff. score1.72.13.1-1.0-1.4-1.5-0.6-1.2-1.6-1.6-1.61.31.6-1.51.61.81.8-1.51.4-1.51.41.41.31.2
Locomotion velocity, session 11.31.42.0-1.2-1.3-1.3-0.9-1.3-1.4-1.4-1.41.41.2-1.41.21.31.3-0.90.8-1.10.80.91.00.6
Locomotion distance, session 10.30.40.9-0.9-0.9-0.7-0.9-0.7-0.7-0.7-0.7-0.10.4-0.40.50.50.5-0.60.8-0.30.80.2-0.00.2
Locomotion velocity, session 20.60.72.9-1.7-1.3-1.1-1.7-1.6-0.8-0.9-0.80.60.3-0.00.2-0.1-0.10.5-0.50.1-0.5-0.3-0.3-0.7
Locomotion distance, session 21.31.84.3-2.1-2.0-1.8-1.9-1.8-1.7-1.7-1.61.11.2-0.81.21.01.0-0.91.0-0.81.00.70.30.4
Locomotion velocity, session 30.91.11.9-0.1-0.6-0.80.4-0.2-1.0-1.0-1.00.91.2-1.21.31.11.1-1.21.2-1.31.21.41.31.3
Locomotion distance, session 34.04.47.9-0.5-1.1-1.40.6-0.4-1.9-1.9-1.92.32.4-2.52.42.32.3-2.32.3-2.52.32.82.62.6
Stereotopy head waving bouts, day 31.31.56.6-2.4-2.0-1.7-2.6-2.1-1.4-1.4-1.30.10.6-0.20.60.20.2-0.40.3-0.10.3-0.2-0.5-0.6
Stereotopy head waving duration, day 31.51.85.7-2.3-2.1-1.9-2.4-2.1-1.7-1.7-1.60.51.0-0.61.00.70.7-0.90.9-0.50.90.2-0.0-0.1
Locomotion velocity, session 71.01.12.91.21.00.91.71.50.30.30.20.50.4-1.20.41.31.3-1.21.0-0.91.00.91.21.4
Locomotion distance, session 71.62.03.9-0.3-0.6-0.70.4-0.1-1.1-1.1-1.11.51.5-2.01.51.91.9-1.81.7-1.61.71.71.61.7
Stereotopy head waving bouts, day 70.20.30.50.3-0.0-0.20.50.2-0.3-0.3-0.30.10.6-0.20.60.70.7-0.70.6-0.60.60.60.70.7
Stereotopy head waving duration, day 70.20.31.21.10.90.71.10.90.60.60.6-0.4-0.20.4-0.20.10.1-0.0-0.10.0-0.1-0.00.20.2
Locomotion velocity, session 80.30.41.4-0.9-0.9-1.0-0.9-1.2-0.8-0.8-0.80.30.6-0.20.60.40.4-0.20.1-0.40.10.20.2-0.0
Locomotion distance, session 81.82.64.6-1.9-2.1-2.1-1.7-2.1-2.0-2.0-2.01.31.6-1.41.61.71.7-1.31.3-1.21.31.10.80.7
Degree of sensitization distance0.80.82.0-0.30.10.4-0.9-0.20.60.60.6-0.7-1.00.8-1.1-0.7-0.70.9-1.01.2-1.0-1.4-1.3-1.4
Degree of sensitization stereotypy0.40.42.01.31.00.81.41.10.50.50.5-0.1-0.10.0-0.00.50.5-0.30.2-0.20.20.30.50.6
Conditioned locomotion1.01.22.11.41.41.41.31.41.31.31.3-1.1-1.11.0-1.0-0.9-0.90.8-0.80.8-0.9-0.6-0.6-0.4
Cocaine response after cond. corrected0.50.62.3-1.2-1.3-1.2-1.5-1.4-0.9-0.9-0.90.30.40.00.4-0.0-0.00.10.1-0.0-0.0-0.1-0.3-0.5
Cocaine response after cond. not corrected0.30.31.3-0.7-0.7-0.6-1.1-1.0-0.3-0.3-0.3-0.2-0.20.4-0.1-0.5-0.50.5-0.40.5-0.5-0.6-0.7-0.8
Cocaine response before conditioning1.51.82.61.21.51.60.91.11.61.61.6-1.5-1.51.0-1.5-1.3-1.31.3-1.41.3-1.3-1.4-1.1-1.0
Saline control response0.30.30.7-0.8-0.7-0.6-0.5-0.5-0.7-0.7-0.70.10.5-0.90.50.60.6-0.60.5-0.50.60.50.40.4
Bone: connectivity density0.91.42.8-0.10.20.4-0.6-0.10.70.80.8-1.7-1.21.3-1.2-1.5-1.51.5-1.51.4-1.4-1.3-1.6-1.5
Bone: cortical apparent density0.30.50.8-0.5-0.8-0.8-0.3-0.4-0.9-0.8-0.80.80.9-0.10.90.30.3-0.70.8-0.70.80.80.60.6
Bone: cortical area2.94.411.63.43.23.03.23.32.62.62.6-2.1-1.81.2-1.7-1.2-1.20.7-0.81.2-0.9-0.8-0.6-0.1
Bone: cortical porosity0.10.10.5-0.5-0.3-0.3-0.5-0.7-0.2-0.3-0.30.50.1-0.30.10.40.40.1-0.3-0.1-0.4-0.00.1-0.2
Bone: cortical porosity0.00.10.2-0.3-0.1-0.1-0.3-0.4-0.0-0.1-0.10.2-0.0-0.1-0.10.20.20.3-0.40.1-0.5-0.10.0-0.3
Bone: cortical thickness2.13.56.72.62.52.42.22.52.32.32.3-2.3-1.81.6-1.8-1.7-1.71.0-1.01.4-1.1-1.1-1.1-0.5
Bone: cortical thickness0.70.92.10.90.80.80.60.80.90.90.9-1.0-0.91.4-0.8-1.4-1.40.9-0.80.8-0.7-0.7-0.8-0.6
Bone: cortical tissue density0.50.71.1-0.7-0.9-1.0-0.5-0.6-1.0-1.0-1.00.91.0-0.21.00.40.4-0.80.9-0.80.90.90.70.7
Condit. Reinf. active minus inactive responses2.83.14.6-2.0-2.0-2.0-1.3-1.7-2.1-2.1-2.12.12.0-1.41.91.61.6-1.51.4-1.81.41.61.51.2
Condit. Reinf. active-inactive response ratio4.64.97.7-2.5-2.7-2.7-1.7-2.4-2.7-2.8-2.82.62.5-1.72.51.81.8-1.61.6-2.21.62.01.91.4
Condit. Reinf. active responses0.60.71.4-1.2-1.1-1.0-0.8-0.8-1.0-1.1-1.01.10.9-0.40.90.70.7-0.70.7-0.80.70.70.60.5
Condit. Reinf. inactive responses2.83.55.21.62.02.31.02.02.32.32.3-2.2-2.11.9-2.1-1.7-1.71.3-1.21.9-1.2-1.8-1.8-1.2
Incentive salience index mean0.20.20.7-0.6-0.5-0.5-0.4-0.4-0.5-0.5-0.50.80.5-0.20.50.40.4-0.30.3-0.50.30.30.40.3
Condit. Reinf. lever presses0.81.22.01.11.31.40.81.41.41.41.4-1.0-1.21.1-1.2-0.8-0.80.7-0.71.0-0.7-1.0-0.9-0.6
Condit. Reinf. active minus inactive responses0.20.30.70.30.20.20.60.5-0.00.00.0-0.30.3-0.50.30.80.8-0.50.8-0.40.70.50.40.7
Condit. Reinf. active-inactive response ratio0.20.30.6-0.6-0.6-0.6-0.5-0.7-0.6-0.6-0.60.50.5-0.60.50.80.8-0.20.3-0.40.20.30.30.2
Condit. Reinf. active responses0.81.12.4-0.5-0.7-0.70.0-0.1-1.0-1.0-1.00.51.2-0.91.21.21.2-1.21.6-1.21.51.21.11.3
Condit. Reinf. inactive responses0.20.20.8-0.2-0.3-0.30.00.1-0.4-0.4-0.40.10.5-0.10.60.10.1-0.70.9-0.60.90.50.50.6
Condit. Reinf. lever presses0.20.30.9-0.1-0.1-0.00.30.2-0.3-0.3-0.30.30.5-1.00.50.70.7-0.70.8-0.60.70.60.60.8
Condit. Reinf. lever reinforcers received0.60.92.1-0.2-0.4-0.50.40.1-0.8-0.7-0.80.41.0-0.91.11.11.1-1.11.4-1.11.41.21.11.3
Conditioned reinforcement - actives0.40.72.41.61.21.01.41.10.90.90.9-0.7-0.50.5-0.5-0.6-0.60.7-0.60.3-0.50.10.00.1
Conditioned reinforcement - inactives1.21.73.51.91.61.21.61.41.31.41.4-1.5-1.01.5-1.0-1.6-1.61.4-1.00.9-1.2-0.7-0.5-0.6
Conditioned locomotion1.62.03.92.01.81.71.51.61.71.71.7-1.8-1.41.3-1.3-1.4-1.41.3-0.81.1-1.1-0.8-0.8-0.7
Patch foraging indifference point 0 sec0.20.51.10.20.20.3-0.2-0.00.50.60.6-1.1-0.80.7-0.8-0.6-0.60.7-0.70.9-0.9-0.9-0.9-0.8
Patch foraging indifference point AUC2.02.94.6-1.7-1.7-1.7-0.9-1.5-1.9-2.0-2.02.11.9-1.91.81.61.6-1.41.5-1.81.51.71.71.4
Delay disc. indifference point, 0s delay4.04.311.01.71.71.50.91.32.02.12.1-2.5-2.13.3-2.0-2.5-2.52.2-2.02.1-2.4-2.0-1.9-1.9
Delay disc. indifference point, 16s delay0.20.20.6-0.3-0.5-0.6-0.1-0.2-0.6-0.6-0.60.70.60.20.60.30.3-0.30.3-0.60.30.80.60.5
Delay disc. indifference point, 2s delay2.02.34.90.70.90.80.10.31.21.31.3-1.6-1.52.2-1.4-2.0-2.01.9-1.71.6-2.0-1.7-1.5-1.7
Delay disc. indifference point, 24s delay0.10.10.50.70.20.00.60.40.10.20.2-0.20.10.40.1-0.1-0.10.2-0.1-0.1-0.20.40.20.2
Delay disc. indifference point, 4s delay0.50.61.20.00.20.2-0.3-0.00.50.50.5-0.7-0.81.0-0.8-0.9-0.91.1-0.90.9-1.1-1.0-0.9-1.0
Delay disc. indifference point, 8s delay0.30.31.60.90.70.61.31.00.30.30.3-0.10.10.10.10.40.4-0.40.1-0.40.30.50.60.7
Indifference point function ln k1.22.13.90.10.60.8-0.60.21.21.21.2-1.6-1.61.8-1.6-1.6-1.61.6-1.61.8-1.7-2.0-1.9-1.9
Indifference point function log k1.22.13.90.10.60.8-0.60.21.21.21.2-1.6-1.61.8-1.6-1.6-1.61.6-1.61.8-1.7-2.0-1.9-1.9
Patch foraging total patch changes 0 sec0.10.20.50.10.10.2-0.1-0.10.30.30.4-0.7-0.50.4-0.5-0.3-0.30.5-0.40.6-0.6-0.5-0.6-0.5
Patch foraging total patch changes 12 sec0.20.20.60.60.70.80.50.60.70.60.6-0.2-0.50.0-0.5-0.2-0.20.5-0.30.3-0.4-0.3-0.1-0.1
Patch foraging total patch changes 18 sec1.52.33.5-0.8-1.1-1.3-0.1-0.8-1.5-1.5-1.51.41.7-1.81.71.91.9-1.51.7-1.71.51.71.71.6
Patch foraging total patch changes 24 sec0.91.52.4-0.7-1.0-1.2-0.2-0.9-1.3-1.3-1.31.21.4-1.61.41.41.4-1.11.3-1.41.11.41.31.2
Patch foraging total patch changes 6 sec0.30.41.0-0.4-0.5-0.5-0.1-0.5-0.6-0.6-0.60.60.7-1.00.60.90.9-0.60.5-0.70.50.70.70.6
Patch foraging time to switch 0 sec0.91.93.31.81.71.51.21.71.61.71.7-1.6-1.41.2-1.4-1.1-1.10.9-1.01.3-1.1-1.1-1.1-0.8
Patch foraging water rate 0 sec0.61.32.9-0.1-0.1-0.10.70.1-0.6-0.7-0.71.41.1-1.71.01.51.5-1.31.3-1.41.41.41.51.6
Patch foraging water rate 12 sec1.63.34.5-1.6-1.7-1.6-0.8-1.3-1.9-2.0-2.02.02.0-2.11.91.91.9-2.01.9-1.92.01.91.71.7
Patch foraging water rate 18 sec0.30.40.9-0.9-0.8-0.6-0.8-0.7-0.7-0.7-0.70.50.5-0.80.50.60.6-0.60.7-0.40.80.40.20.3
Patch foraging water rate 24 sec0.10.20.6-0.1-0.2-0.20.1-0.3-0.3-0.4-0.40.50.4-0.80.50.30.3-0.40.5-0.50.60.50.50.5
Patch foraging water rate 6 sec0.20.30.90.20.10.20.50.2-0.1-0.1-0.10.20.4-0.70.40.60.6-0.80.8-0.61.00.70.60.8
Seeking ratio, delayed vs. immediate footshock1.82.24.1-2.0-1.9-1.7-1.7-1.7-1.7-1.7-1.71.81.3-1.61.31.61.6-1.31.0-1.11.10.90.70.6
Distance traveled before self-admin0.20.30.9-0.7-0.9-0.9-0.6-0.7-0.8-0.8-0.80.10.60.00.70.10.1-0.20.3-0.40.40.50.20.1
Distance traveled after self-admin1.51.85.00.40.60.7-0.20.31.01.11.1-1.9-1.42.2-1.3-1.5-1.51.5-1.71.6-1.3-1.5-1.7-1.5
Extensor digitorum longus weight0.62.57.42.52.52.52.32.72.12.02.0-1.5-1.40.3-1.4-0.2-0.20.2-0.30.8-0.4-0.7-0.30.1
Bone: elastic displacement1.01.23.51.91.81.71.81.71.51.41.4-0.3-0.90.1-1.0-0.2-0.20.5-0.60.5-0.6-0.5-0.1-0.0
Bone: elastic work2.43.17.22.72.72.62.32.42.42.32.3-1.6-1.81.0-1.7-0.9-0.91.0-1.11.2-1.1-1.1-0.7-0.5
Bone: endosteal estimation0.40.93.41.71.61.51.81.71.11.01.0-0.1-0.4-0.4-0.40.30.3-0.20.0-0.10.00.10.60.6
Bone: endosteal perimeter0.51.13.51.71.71.61.61.91.31.31.3-0.8-0.80.1-0.8-0.3-0.30.1-0.30.4-0.3-0.4-0.00.1
Epididymis fat weight0.82.810.13.12.82.53.23.02.02.01.9-0.9-1.00.3-1.00.20.20.2-0.40.3-0.4-0.20.40.6
Delta time in closed arm before/after self-admin0.90.92.4-1.2-1.5-1.5-1.2-1.1-1.3-1.2-1.20.70.9-0.31.00.60.6-0.50.5-0.60.50.70.30.2
Delta time in open arm before/after self-admin0.70.72.11.51.41.41.41.31.11.11.1-0.9-0.70.1-0.7-0.1-0.10.00.00.4-0.0-0.4-0.20.2
Diff in mean of infusions in LGA sessions0.91.12.7-1.4-1.6-1.7-1.2-1.2-1.5-1.4-1.40.71.2-0.31.20.50.5-0.80.8-0.80.80.80.50.4
Delay discount exponential model param0.30.41.2-0.8-0.6-0.5-0.7-0.6-0.6-0.6-0.60.70.4-1.10.40.70.7-0.70.6-0.40.70.30.30.3
Extinction: sum of active levers before priming0.40.51.40.60.30.11.00.6-0.2-0.1-0.20.40.6-1.20.60.80.8-0.80.6-0.80.80.90.91.1
Active lever presses in extinction session 61.11.12.30.70.60.50.20.30.80.90.9-1.3-1.01.5-0.9-1.4-1.41.5-1.51.1-1.3-1.0-1.0-1.1
Bone: final force2.13.38.52.92.92.82.92.92.42.32.3-1.6-1.50.7-1.5-0.8-0.80.6-0.80.8-0.7-0.7-0.20.1
Bone: final moment1.82.96.82.52.62.52.52.52.22.22.1-1.6-1.50.8-1.5-0.9-0.90.8-0.91.0-0.9-0.8-0.4-0.1
Food consumed during 24 hour testing period0.50.71.7-0.8-0.7-0.6-0.5-0.5-0.8-0.8-0.80.60.8-1.30.81.01.0-1.11.1-0.81.10.70.60.7
Glucose2.23.47.90.3-0.1-0.41.40.1-1.0-1.2-1.22.41.9-2.51.82.42.4-1.91.8-2.41.72.42.82.5
Heart weight0.71.13.71.91.71.61.81.91.31.31.2-0.7-0.70.4-0.7-0.2-0.20.1-0.10.3-0.1-0.10.10.3
Delay discount hyperbolic model param0.30.41.2-0.7-0.6-0.5-0.6-0.6-0.6-0.6-0.60.70.5-1.10.50.70.7-0.70.6-0.50.80.40.30.4
Intermittent access intake day 1-15 change0.40.92.9-1.3-1.6-1.7-1.6-1.7-1.2-1.1-1.10.20.50.40.6-0.4-0.40.2-0.20.0-0.40.1-0.4-0.6
Intermittent access intake escalation0.20.51.4-0.8-1.1-1.2-1.1-1.2-0.7-0.6-0.6-0.10.20.60.2-0.6-0.60.5-0.50.3-0.7-0.1-0.5-0.7
Intermittent access intake escalation 20.60.71.5-0.8-0.8-0.8-1.2-1.1-0.3-0.3-0.2-0.3-0.31.1-0.2-1.1-1.11.0-0.70.7-1.0-0.7-0.9-1.1
Intermitt. access day 1 inactive lever presses0.20.71.7-0.30.10.3-0.7-0.50.50.50.6-0.9-1.00.5-0.9-0.9-0.91.0-0.71.2-1.1-1.1-1.3-1.3
Intermitt. access day 15 inactive lever presses0.30.71.8-0.7-1.1-1.3-0.6-1.0-1.2-1.2-1.20.81.0-0.61.10.50.5-0.50.3-0.80.30.90.70.4
Intermitt. access escalation Index1.01.42.6-1.6-1.5-1.5-1.3-1.5-1.4-1.4-1.41.51.2-1.11.11.01.0-0.91.1-0.90.70.80.70.5
Intermittent access day 1 total infusions0.30.51.61.21.11.01.21.10.80.80.8-0.8-0.50.5-0.5-0.6-0.60.4-0.20.3-0.3-0.2-0.00.0
Intermittent access day 15 total infusions0.10.10.50.70.40.10.60.40.20.20.2-0.4-0.10.5-0.0-0.6-0.60.5-0.30.1-0.50.20.1-0.1
Intermittent access terminal intake (last 3 days)0.10.10.30.40.2-0.10.40.1-0.00.0-0.0-0.10.10.50.2-0.5-0.50.3-0.2-0.1-0.40.30.2-0.0
Intermittent access total infusions0.20.30.60.80.70.40.70.50.50.50.5-0.4-0.30.5-0.3-0.7-0.70.5-0.50.2-0.6-0.2-0.0-0.2
Intermittent access day 1 locomotion0.30.41.51.21.00.71.21.00.70.70.7-0.9-0.40.5-0.3-0.5-0.50.4-0.20.2-0.2-0.0-0.00.1
Intermittent access day 15 total locomotion0.20.31.61.20.70.51.10.90.40.50.5-0.7-0.10.1-0.0-0.1-0.1-0.00.1-0.00.10.50.20.4
Intermittent access total locomotion0.10.10.50.70.40.20.70.40.20.20.2-0.4-0.00.50.0-0.3-0.30.3-0.40.0-0.20.20.20.1
Intermittent access standard deviation0.10.20.7-0.5-0.7-0.8-0.6-0.7-0.6-0.6-0.50.20.30.40.4-0.5-0.50.10.3-0.1-0.10.1-0.1-0.2
Left kidney weight1.88.517.64.04.24.13.43.93.83.83.7-2.5-3.02.1-3.0-1.9-1.92.0-1.92.2-1.9-2.0-1.4-1.1
Right kidney weight1.25.612.23.53.53.33.03.23.13.03.0-2.1-2.31.5-2.3-1.4-1.41.5-1.51.6-1.5-1.4-0.9-0.7
Cocaine induced anxiety0.40.62.1-1.4-1.2-1.1-1.3-1.3-0.9-0.9-0.91.00.5-0.10.40.10.10.10.2-0.2-0.10.1-0.0-0.3
Post-drug Anxiety0.30.30.9-0.7-0.7-0.7-1.0-0.9-0.4-0.3-0.30.0-0.10.6-0.0-0.4-0.40.6-0.60.4-0.6-0.4-0.6-0.8
Baseline Anxiety0.70.83.82.01.41.11.71.51.01.11.0-1.3-0.50.2-0.40.10.10.1-0.30.3-0.1-0.1-0.00.3
Tail length0.20.83.21.61.41.21.81.60.80.70.7-0.2-0.1-0.5-0.10.50.5-0.80.6-0.40.60.40.70.9
Length with tail1.15.018.34.13.73.44.34.12.62.52.5-1.5-1.2-0.1-1.10.20.2-0.60.40.20.40.20.61.3
Length without tail1.54.815.03.93.63.43.83.92.72.72.7-1.9-1.60.7-1.5-0.3-0.3-0.00.10.7-0.2-0.3-0.00.7
Times rat made contact with spout3.33.85.4-1.9-2.2-2.2-1.3-1.5-2.3-2.3-2.32.02.2-1.92.21.81.8-1.81.9-1.91.91.81.61.5
Lifetime Intake0.10.10.50.70.50.40.70.50.30.30.3-0.2-0.10.2-0.1-0.5-0.50.2-0.20.0-0.30.10.20.0
Liver weight, left0.20.31.00.80.80.81.00.80.50.40.40.2-0.1-0.8-0.10.40.4-0.20.0-0.30.30.30.50.6
Liver weight, right0.61.13.81.71.81.72.01.81.31.21.2-0.4-0.70.3-0.7-0.4-0.40.4-0.20.1-0.20.10.40.4
Locomotor activity2.64.18.0-0.3-0.6-0.70.70.1-1.4-1.4-1.52.42.0-2.82.02.82.8-2.52.4-2.42.42.22.52.4
Locomotor testing distance0.81.43.20.20.0-0.00.80.5-0.5-0.6-0.61.21.1-1.81.01.71.7-1.61.4-1.41.61.31.51.6
Locomotor testing rearing0.81.73.50.60.40.21.30.9-0.3-0.4-0.41.31.0-1.91.01.81.8-1.71.5-1.51.61.51.71.8
Locomotion in novel chamber0.60.71.5-0.8-0.9-0.9-0.5-0.8-1.0-1.0-1.00.60.8-0.60.91.21.2-0.91.0-0.80.70.80.60.6
Locomotion in novel chamber post-restriction0.30.51.40.2-0.3-0.60.5-0.1-0.6-0.6-0.60.60.9-0.40.90.80.8-0.50.5-0.90.41.21.00.8
Fecal boli incidents, locomotor time 11.21.74.20.20.70.8-0.3-0.21.11.01.1-1.1-1.50.9-1.4-1.4-1.41.8-2.01.6-1.9-1.6-1.5-1.7
Change in fecal boli incidents, locomotor task6.96.813.6-1.9-2.4-2.3-1.0-1.3-2.7-2.7-2.72.32.8-2.82.82.92.9-3.23.7-2.63.22.62.22.5
Time >=10cm from walls, locomotor time 10.50.62.61.61.21.01.61.20.80.80.8-0.6-0.3-0.2-0.3-0.1-0.1-0.20.00.0-0.00.10.20.4
Bouts of movement, locomotor time 10.91.03.10.70.80.80.30.41.01.01.0-0.7-1.10.8-1.1-0.8-0.81.3-1.81.1-1.3-1.0-1.0-1.1
Total resting periods, locomotor time 10.60.62.30.70.70.60.40.40.80.80.8-0.6-0.80.6-0.8-0.6-0.61.1-1.50.8-1.1-0.8-0.7-0.8
Rest time, locomotor task time 10.81.12.91.61.71.61.71.61.31.31.3-0.6-0.80.4-0.8-0.6-0.60.5-0.50.4-0.5-0.30.00.1
Distance moved, locomotor task time 10.20.31.2-1.0-0.8-0.6-1.1-0.9-0.5-0.5-0.50.20.2-0.20.10.30.3-0.20.2-0.00.2-0.1-0.3-0.2
Vertical activity count, locomotor time 10.40.92.4-1.5-1.4-1.3-1.5-1.5-1.1-1.1-1.10.70.7-0.70.70.70.7-0.40.3-0.40.40.30.1-0.0
Time >=10cm from walls, locomotor time 20.40.61.70.80.50.31.30.7-0.0-0.1-0.10.40.6-0.80.60.60.6-0.91.0-0.90.80.91.21.2
Bouts of movement, locomotor time 20.10.10.50.1-0.1-0.20.10.0-0.2-0.2-0.20.60.3-0.70.30.50.5-0.3-0.0-0.40.40.40.40.4
Total resting periods, locomotor time 20.10.20.40.40.10.00.50.3-0.1-0.1-0.10.60.3-0.60.30.50.5-0.4-0.1-0.50.40.60.60.6
Rest time, locomotor task time 20.50.73.11.51.41.21.81.40.90.80.8-0.3-0.20.2-0.30.10.1-0.10.0-0.10.10.20.50.6
Distance moved, locomotor task time 20.40.42.2-1.4-1.1-0.8-1.5-1.1-0.7-0.7-0.70.10.2-0.00.2-0.0-0.0-0.20.40.10.3-0.2-0.4-0.3
Vertical activity count, locomotor time 20.50.73.3-1.5-1.2-1.0-1.8-1.4-0.6-0.6-0.6-0.2-0.00.5-0.0-0.8-0.80.3-0.00.5-0.2-0.5-0.9-0.8
Light reinforcement 10.51.24.21.81.81.72.01.91.41.31.3-1.1-0.70.4-0.7-0.4-0.40.4-0.50.3-0.3-0.10.20.4
Light reinforcement 25.07.611.02.53.03.11.72.43.23.23.2-3.3-3.12.9-3.1-2.6-2.62.6-2.52.8-2.5-2.6-2.4-2.0
Bone: marrow area0.40.83.31.71.61.41.81.61.00.90.9-0.1-0.4-0.4-0.40.40.4-0.30.1-0.10.10.10.60.6
Bone: maximum diameter1.01.86.12.42.22.02.32.51.61.61.6-1.3-1.00.4-0.9-0.6-0.6-0.0-0.10.5-0.1-0.3-0.10.3
Bone: maximum force1.42.56.32.52.52.42.52.42.02.02.0-1.6-1.30.7-1.3-0.9-0.90.5-0.60.8-0.7-0.6-0.20.1
Bone: maximum moment1.22.24.82.12.22.12.02.11.91.91.8-1.6-1.40.9-1.4-1.0-1.00.7-0.80.9-0.9-0.8-0.5-0.2
Mean time between licks in bursts0.30.71.8-0.9-0.4-0.3-1.2-1.10.10.00.00.3-0.60.5-0.6-0.8-0.81.3-1.40.8-1.4-1.1-0.8-1.3
Mean num. licks in bursts6.810.515.5-3.1-3.6-3.8-1.9-2.9-3.9-3.9-3.93.63.8-2.63.82.82.8-2.92.8-3.42.83.23.02.5
Cd content in liver0.60.71.6-0.1-0.3-0.40.3-0.2-0.6-0.6-0.61.00.8-1.20.81.31.3-0.90.9-1.00.90.91.01.0
Co content in liver0.20.31.10.80.80.81.01.10.60.50.5-0.3-0.2-0.3-0.20.20.2-0.20.2-0.10.20.10.30.4
Cu content in liver0.30.41.1-1.0-0.8-0.7-0.7-1.0-0.8-0.8-0.80.90.6-0.30.60.30.3-0.30.3-0.50.30.50.50.2
Fe content in liver1.11.33.5-1.8-1.8-1.7-1.8-1.9-1.5-1.5-1.40.80.9-1.00.90.60.6-0.30.3-0.50.40.50.2-0.2
K content in liver0.90.91.30.80.90.90.50.51.01.01.0-1.1-1.00.9-1.0-0.9-0.91.1-1.11.0-1.1-0.8-0.9-0.8
Mg content in liver2.42.53.31.61.71.71.21.31.81.81.8-1.7-1.61.6-1.6-1.6-1.61.7-1.71.5-1.7-1.2-1.2-1.1
Mn content in liver0.10.10.3-0.20.10.2-0.20.00.30.30.3-0.2-0.40.4-0.4-0.5-0.50.6-0.60.4-0.6-0.4-0.4-0.4
Na content in liver0.10.10.40.20.10.00.30.10.10.10.10.1-0.10.4-0.1-0.5-0.50.6-0.60.1-0.50.1-0.0-0.2
Rb content in liver0.50.61.21.01.01.01.10.80.90.80.8-0.5-0.60.5-0.6-0.8-0.80.8-0.80.4-0.8-0.2-0.1-0.2
Se content in liver0.70.81.9-0.8-0.4-0.3-1.2-0.80.20.20.2-1.0-0.80.9-0.7-0.9-0.91.1-1.11.1-1.1-0.8-1.3-1.4
Sr content in liver3.12.74.11.11.41.40.41.11.71.71.7-1.4-1.81.4-1.8-1.9-1.92.0-2.01.8-2.0-1.8-1.6-1.7
Zn content in liver0.20.21.2-1.1-0.7-0.5-1.0-0.9-0.3-0.3-0.3-0.1-0.00.1-0.10.00.00.1-0.00.2-0.1-0.3-0.5-0.4
Bone: minimum diameter0.50.93.11.61.61.51.71.81.11.11.1-0.7-0.6-0.1-0.60.10.1-0.20.00.1-0.1-0.00.20.4
Time in familiar zone, hab. session 10.70.62.3-1.5-1.3-1.3-1.5-1.4-1.0-0.9-0.90.20.50.10.5-0.0-0.00.10.0-0.10.0-0.0-0.2-0.4
Time in novel zone, hab. session 10.20.20.50.70.70.70.70.70.60.50.5-0.3-0.40.0-0.4-0.1-0.10.0-0.20.2-0.2-0.2-0.10.0
Total zone transitions, hab. session 10.20.30.8-0.6-0.5-0.4-0.3-0.2-0.5-0.6-0.50.90.6-0.80.50.60.6-0.50.6-0.50.60.40.50.5
Total locomotion distance, hab. session 10.50.71.2-0.7-0.8-0.7-0.4-0.4-0.9-0.9-0.91.00.9-1.10.91.01.0-1.01.0-0.81.00.70.60.8
Locomotion velocity, hab. session 10.20.30.80.1-0.0-0.00.30.3-0.2-0.2-0.20.60.4-0.90.40.70.7-0.80.8-0.50.80.50.50.7
Time in familiar zone, hab. session 21.51.55.9-2.1-2.1-2.0-2.4-2.4-1.5-1.4-1.40.40.70.10.70.00.00.00.0-0.00.0-0.1-0.5-0.7
Time in novel zone, hab. session 21.61.66.71.91.81.72.62.31.11.00.90.3-0.0-0.9-0.10.80.8-0.70.6-0.70.60.81.21.5
Total zone transitions, hab. session 21.51.93.2-1.0-1.2-1.1-0.5-0.6-1.4-1.3-1.31.11.4-1.71.41.81.8-1.81.8-1.31.81.31.11.3
Total locomotion distance, hab. session 21.72.33.9-1.2-1.4-1.3-0.7-0.8-1.5-1.5-1.51.11.5-1.91.52.02.0-1.91.9-1.41.91.31.11.4
Locomotion velocity, hab. session 21.21.62.8-1.0-1.2-1.1-0.6-0.7-1.3-1.3-1.30.91.2-1.61.31.71.7-1.71.7-1.21.71.00.91.2
Novel to familiar place preference ratio0.40.40.8-0.4-0.5-0.6-0.1-0.3-0.7-0.7-0.70.90.8-0.60.70.60.6-0.70.6-0.70.60.70.70.6
Novelty place preference0.30.30.8-0.3-0.5-0.5-0.1-0.2-0.6-0.6-0.60.90.7-0.60.60.60.6-0.60.5-0.60.50.70.60.5
Time in novel zone, NPP test0.10.10.5-0.2-0.3-0.3-0.0-0.1-0.4-0.4-0.40.70.4-0.40.40.30.3-0.40.3-0.40.30.50.40.3
Total zone transitions, NPP test0.10.10.5-0.10.00.2-0.30.20.30.30.3-0.7-0.40.5-0.4-0.2-0.20.2-0.10.5-0.1-0.5-0.6-0.4
Total locomotion distance, NPP test0.10.10.3-0.4-0.5-0.4-0.5-0.3-0.4-0.4-0.40.10.3-0.10.30.40.4-0.40.4-0.20.40.10.00.1
Locomotion velocity, NPP test0.40.50.7-0.7-0.9-0.8-0.6-0.6-0.8-0.8-0.80.50.7-0.60.70.80.8-0.80.8-0.60.80.50.40.5
Intraocular pressure0.00.00.10.1-0.0-0.00.1-0.10.00.10.1-0.2-0.00.1-0.00.10.10.2-0.40.1-0.20.2-0.2-0.0
Delta distance traveled before/after self-admin1.61.63.00.71.01.10.20.71.31.31.4-1.5-1.41.7-1.4-1.2-1.21.4-1.61.5-1.2-1.5-1.4-1.3
Delta ambulatory time before/after self-admin1.92.34.5-0.10.40.6-0.9-0.11.11.11.2-1.4-1.62.1-1.6-1.7-1.71.9-2.11.9-1.7-2.0-2.0-2.0
Parametrial fat weight0.40.91.7-0.5-0.9-1.3-0.1-1.1-1.2-1.2-1.21.31.2-0.71.20.40.4-0.60.5-1.10.21.21.20.7
Pavlov. Cond. lever latency3.34.15.5-1.5-2.0-2.1-0.8-1.6-2.3-2.3-2.31.92.3-2.12.32.02.0-2.02.0-2.22.02.22.01.8
Pavlov. Cond. magazine entry latency0.30.42.1-1.2-0.8-0.5-1.4-1.0-0.3-0.3-0.2-0.8-0.30.4-0.3-0.2-0.20.2-0.20.6-0.2-0.6-1.0-0.8
Pavlov. Cond. change in total contacts0.40.40.80.20.60.70.00.40.80.70.7-0.3-0.80.5-0.9-0.5-0.50.8-0.90.8-0.9-0.9-0.7-0.7
Pavlov. Cond. index score1.11.42.70.10.50.8-0.40.31.11.11.1-1.5-1.41.3-1.4-1.2-1.21.2-1.21.5-1.2-1.5-1.6-1.4
Pavlov. Cond. latency score1.21.52.70.20.71.0-0.30.41.21.21.2-1.4-1.51.4-1.5-1.3-1.31.3-1.31.6-1.3-1.6-1.6-1.5
Pavlov. Cond. lever contacts2.93.54.91.21.71.90.51.32.12.12.1-1.9-2.21.9-2.2-1.9-1.91.9-1.92.1-1.9-2.2-2.0-1.8
Pavlov. Cond. magazine entry number0.30.42.11.31.00.71.51.00.60.50.50.4-0.0-0.1-0.0-0.1-0.10.1-0.1-0.3-0.10.30.70.5
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.1-0.0-0.0-0.20.10.00.00.0-0.2-0.10.3-0.1-0.2-0.20.00.10.10.1-0.2-0.2-0.1
Pavlov. Cond. lever-magazine prob. diff.1.31.73.10.20.71.0-0.40.41.21.21.3-1.6-1.61.4-1.6-1.3-1.31.3-1.31.7-1.3-1.7-1.8-1.5
Pavlov. Cond. response bias1.21.53.4-0.20.30.7-0.70.11.01.01.0-1.7-1.41.4-1.4-1.2-1.21.2-1.21.6-1.2-1.6-1.8-1.5
Pavlov. Cond. lever latency0.91.32.11.01.11.10.50.81.21.21.3-1.4-1.31.5-1.2-1.1-1.11.0-1.11.2-1.0-1.1-1.2-1.0
Pavlov. Cond. magazine entry latency0.20.20.90.90.70.71.00.90.40.40.4-0.1-0.1-0.2-0.10.00.0-0.10.3-0.20.30.20.30.5
Pavlov. Cond. change in total contacts0.10.20.3-0.2-0.2-0.20.1-0.0-0.3-0.3-0.40.50.4-0.40.40.50.5-0.50.6-0.50.50.50.60.5
Pavlov. Cond. index score0.20.20.5-0.3-0.3-0.3-0.0-0.2-0.4-0.4-0.50.60.5-0.70.50.40.4-0.40.6-0.60.60.50.60.5
Pavlov. Cond. latency score0.10.10.3-0.3-0.2-0.2-0.0-0.2-0.3-0.3-0.30.40.4-0.60.40.30.3-0.30.4-0.40.40.40.40.4
Pavlov. Cond. lever contacts1.21.72.3-1.3-1.4-1.4-0.8-1.1-1.5-1.5-1.51.41.4-1.51.41.21.2-1.21.3-1.31.21.21.21.0
Pavlov. Cond. magazine entry number0.60.71.8-1.3-1.3-1.3-1.3-1.3-1.1-1.1-1.00.30.7-0.30.70.50.5-0.60.5-0.40.50.30.00.0
Pavlov. Cond. intertrial magazine entries0.40.61.5-0.8-0.4-0.2-1.1-0.60.20.20.2-1.0-0.71.1-0.7-0.9-0.90.8-0.70.9-0.7-1.0-1.2-1.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.3-0.2-0.2-0.1-0.2-0.3-0.4-0.40.50.4-0.60.40.30.3-0.30.5-0.50.50.40.50.4
Pavlov. Cond. response bias0.40.51.0-0.4-0.5-0.5-0.0-0.2-0.7-0.7-0.70.90.8-1.00.80.80.8-0.80.9-0.90.80.80.90.8
Time in closed arm before self-admin0.20.31.0-0.30.00.20.00.2-0.1-0.2-0.20.40.2-1.00.20.80.8-0.70.7-0.50.80.30.50.6
Time in closed arm after self-admin1.31.42.3-1.5-1.4-1.2-1.2-1.1-1.3-1.3-1.30.91.1-1.41.01.31.3-1.21.3-0.91.20.90.60.6
Time in open arm before self-admin0.60.61.30.90.90.80.70.60.90.90.8-0.3-0.70.4-0.7-0.9-0.91.0-1.20.6-1.1-0.6-0.4-0.6
Time in open arm after self-admin1.31.43.21.81.81.71.61.51.61.61.6-1.0-1.10.7-1.1-0.5-0.50.7-0.90.8-0.8-0.9-0.5-0.3
Bone: periosteal estimation1.53.110.23.23.02.73.23.12.22.22.1-1.2-1.20.3-1.2-0.3-0.30.1-0.30.5-0.3-0.30.20.5
Bone: periosteal perimeter1.62.78.83.02.72.42.92.92.02.02.0-1.4-1.20.4-1.1-0.5-0.50.2-0.30.5-0.4-0.40.10.4
Bone: post-yield work0.30.51.8-1.3-1.1-1.0-1.4-1.3-0.8-0.7-0.7-0.00.20.40.3-0.5-0.5-0.0-0.10.1-0.1-0.1-0.4-0.5
Progressive ratio test 1 active lever presses0.60.82.51.61.41.21.61.51.01.01.0-0.8-0.60.5-0.5-0.5-0.50.4-0.10.3-0.3-0.20.10.2
Progressive ratio test 1 breakpoint0.50.72.11.51.31.11.41.31.01.00.9-0.7-0.50.5-0.5-0.5-0.50.4-0.10.3-0.3-0.20.10.1
Progressive ratio test 1 inactive lever presses0.30.40.80.90.80.60.80.30.70.70.7-0.7-0.60.6-0.5-0.8-0.80.8-0.60.5-0.8-0.5-0.3-0.4
Progressive ratio test 2 active lever presses1.21.42.31.31.10.80.80.71.11.11.1-1.4-1.11.3-1.0-1.5-1.51.5-1.41.1-1.4-0.8-0.9-1.0
Progressive ratio test 2 breakpoint1.21.42.31.31.10.80.80.71.11.11.1-1.4-1.11.3-1.0-1.5-1.51.5-1.41.1-1.4-0.8-0.8-1.0
Progressive ratio test 2 inactive lever presses0.50.82.81.71.20.81.41.00.90.90.9-1.0-0.60.9-0.5-0.9-0.90.9-0.90.5-0.9-0.2-0.1-0.3
Incentive Sensitization - Responses1.31.84.20.80.80.60.20.11.01.11.1-1.2-1.31.5-1.2-1.8-1.82.0-2.11.4-2.0-1.3-1.3-1.6
Incentive Sensitization - Breakpoint1.52.04.30.90.90.70.30.21.11.11.1-1.3-1.31.6-1.3-1.9-1.92.1-2.11.5-2.0-1.3-1.3-1.6
Sum of active levers in priming session hrs 5-61.41.32.40.80.70.70.20.31.01.11.1-1.5-1.20.9-1.1-1.4-1.41.4-1.61.3-1.2-1.2-1.3-1.2
Progressive ratio0.20.40.90.30.20.10.80.3-0.2-0.2-0.20.60.5-0.80.50.70.7-0.60.8-0.70.60.70.90.9
Food seeking constrained by brief footshock2.12.65.42.22.32.21.92.12.12.12.0-1.7-1.60.7-1.6-1.2-1.21.2-1.11.2-0.9-1.2-0.8-0.5
Seeking ratio, punishment vs. effort0.71.01.50.50.80.90.00.61.01.01.0-1.2-1.20.8-1.2-1.1-1.11.0-1.11.2-0.8-1.2-1.2-1.0
Retroperitoneal fat weight0.21.04.61.71.10.72.11.40.40.30.20.90.5-0.50.50.50.5-0.60.6-1.00.31.21.51.3
Reaction time number correct0.20.41.10.30.30.30.90.6-0.1-0.1-0.20.30.5-0.70.50.80.8-0.80.7-0.70.90.80.91.1
Reaction time mean minus median0.51.22.8-1.4-1.6-1.7-1.3-1.4-1.4-1.4-1.41.31.1-0.51.10.50.5-0.70.6-0.80.40.70.50.3
Reaction time mean minus median AUC0.20.51.8-0.3-0.5-0.60.1-0.2-0.7-0.7-0.71.40.9-0.80.80.60.6-0.70.7-0.90.40.80.90.7
Reaction time num false alarms1.72.44.61.01.21.20.51.11.51.51.5-1.7-1.52.1-1.5-2.1-2.11.8-1.61.6-1.5-1.4-1.5-1.3
Reaction time num false alarms AUC1.82.84.71.31.41.40.71.21.71.71.7-1.9-1.72.2-1.7-2.2-2.21.9-1.71.7-1.5-1.6-1.6-1.4
Reaction time trials correct on left0.20.41.10.30.30.30.90.6-0.1-0.1-0.20.30.5-0.70.50.80.8-0.80.7-0.70.90.80.91.1
Reaction time trials on left0.30.51.30.20.10.10.70.4-0.3-0.3-0.30.50.6-0.80.60.90.9-1.00.9-0.91.10.91.01.2
Reaction time mean0.40.62.4-1.2-1.2-1.1-1.5-1.1-0.6-0.6-0.60.30.10.80.1-0.6-0.60.3-0.40.3-0.4-0.2-0.6-0.8
Reaction time mean AUC0.30.52.2-1.2-1.3-1.2-1.5-1.1-0.8-0.8-0.70.50.30.50.3-0.3-0.30.0-0.20.1-0.20.0-0.4-0.5
Median of all reaction times0.50.61.8-0.9-0.7-0.6-1.4-0.7-0.1-0.1-0.1-0.2-0.41.3-0.4-1.0-1.00.8-0.90.8-0.8-0.7-1.0-1.2
Reaction time omissions3.24.67.2-2.2-2.6-2.6-1.4-1.8-2.7-2.6-2.62.02.5-1.42.51.71.7-2.02.2-2.12.12.21.71.7
Reaction time false alarm rate2.73.76.60.91.21.30.10.91.71.81.8-2.1-2.02.6-2.0-2.6-2.62.3-2.12.2-2.1-2.1-2.1-2.0
Reaction time premature initiation rate0.10.10.3-0.5-0.4-0.3-0.3-0.1-0.3-0.4-0.40.30.3-0.10.3-0.2-0.2-0.20.3-0.30.30.20.20.2
Reaction time premature initiations0.40.81.5-0.5-0.5-0.50.20.0-0.8-0.8-0.80.81.0-1.01.00.70.7-1.11.1-1.11.21.11.11.2
Std. dev. reaction times0.71.43.3-1.5-1.7-1.8-1.3-1.4-1.6-1.5-1.51.51.3-0.31.30.40.4-0.80.8-0.90.50.90.70.4
Reaction time trials completed0.30.51.30.20.10.10.70.4-0.3-0.3-0.30.50.6-0.80.60.90.9-1.00.9-0.91.10.91.01.2
Reaction time trials AUC0.20.41.10.20.10.20.70.5-0.2-0.2-0.30.40.5-0.70.50.80.8-0.90.8-0.81.00.80.91.1
Run reversals in cocaine runway, females1.21.23.1-0.3-0.3-0.3-1.0-0.70.20.30.4-1.3-0.91.8-0.8-1.5-1.51.3-1.31.3-1.4-1.2-1.5-1.6
Run reversals in cocaine runway, males0.30.30.80.60.30.10.80.4-0.1-0.1-0.20.70.5-0.70.50.60.6-0.40.5-0.60.30.60.90.7
Latency to leave start box in cocaine runway1.11.22.21.51.41.31.31.11.21.31.3-1.1-1.01.2-0.9-1.3-1.31.0-0.90.8-0.7-0.7-0.5-0.4
Latency to leave start box in cocaine runway, F3.13.55.72.42.32.11.92.02.12.22.2-2.1-1.82.2-1.7-2.2-2.21.7-1.31.5-1.3-1.3-1.1-0.9
Latency to leave start box in cocaine runway, M0.30.30.7-0.3-0.4-0.4-0.1-0.5-0.5-0.5-0.50.70.6-0.80.60.60.6-0.60.3-0.60.60.60.60.6
Std. dev. time between licks in bursts0.10.20.40.30.50.50.50.20.50.40.40.2-0.3-0.1-0.4-0.3-0.30.6-0.60.1-0.6-0.30.1-0.1
Total sessions with >9 infusions0.30.30.60.1-0.1-0.30.40.1-0.4-0.4-0.40.50.7-0.80.70.60.6-0.70.8-0.70.70.80.80.8
Short access day 1 total inactive lever presses0.10.20.80.20.20.10.0-0.20.20.30.3-0.2-0.40.3-0.3-0.6-0.60.6-0.90.5-0.7-0.4-0.4-0.5
Short access day 10 total inactive lever presses0.10.41.0-0.7-0.3-0.2-0.9-0.90.10.10.1-0.3-0.50.5-0.5-0.4-0.40.7-0.40.7-0.8-0.8-0.8-1.0
Short access day 1 total infusions0.10.10.30.40.1-0.00.50.2-0.1-0.0-0.1-0.10.3-0.50.30.40.4-0.3-0.1-0.30.30.50.30.4
Short access day 10 total infusions0.81.01.8-0.4-0.5-0.60.1-0.1-0.9-0.9-0.90.91.1-1.21.11.21.2-1.31.0-1.21.31.21.21.2
Short access total infusions0.20.20.4-0.1-0.2-0.30.10.0-0.4-0.4-0.40.30.5-0.60.60.40.4-0.60.6-0.50.60.60.50.5
Short access day 1 locomotion0.10.20.90.10.00.10.30.2-0.1-0.1-0.10.20.3-0.90.30.60.6-0.50.1-0.30.60.50.30.5
Short access day 10 total locomotion0.50.82.2-1.5-1.5-1.4-1.5-1.4-1.2-1.2-1.20.50.7-0.50.80.60.6-0.40.3-0.40.50.50.1-0.1
Short access total locomotion1.11.31.9-1.1-1.3-1.3-0.8-1.0-1.4-1.4-1.40.91.2-1.11.31.11.1-1.11.1-1.11.11.20.80.8
One hour access (0.3 mA shock)1.31.52.71.61.51.31.31.21.41.31.3-1.0-1.11.0-1.1-1.5-1.51.3-1.10.9-1.4-0.7-0.5-0.7
Compulsive drug intake0.80.91.6-0.00.50.7-0.40.10.90.80.8-0.9-1.10.7-1.2-1.3-1.31.2-1.11.1-1.1-1.0-1.1-1.1
One hour access (shock baseline)0.10.21.21.10.70.31.00.70.40.40.4-0.2-0.10.4-0.1-0.3-0.30.3-0.2-0.0-0.50.10.30.1
Social response proportion0.81.02.7-1.2-0.7-0.4-1.6-0.90.00.00.1-0.5-0.71.1-0.7-1.2-1.21.1-1.01.0-1.0-1.1-1.3-1.5
Social responses0.00.00.2-0.4-0.2-0.2-0.4-0.2-0.1-0.1-0.1-0.1-0.0-0.0-0.0-0.3-0.30.1-0.10.1-0.2-0.1-0.1-0.2
Social time0.20.30.6-0.1-0.2-0.3-0.5-0.60.00.00.1-0.5-0.30.4-0.3-0.8-0.80.7-0.70.5-0.8-0.4-0.6-0.8
Soleus weight1.44.26.62.12.52.61.42.02.62.52.5-2.0-2.31.6-2.3-1.9-1.91.7-1.72.0-1.8-1.9-1.6-1.4
Bone: stiffness0.40.73.41.51.31.11.81.60.70.70.7-0.4-0.1-0.3-0.10.20.2-0.50.4-0.40.50.50.70.9
Tibialis anterior weight0.30.93.81.91.61.31.91.41.01.01.0-0.7-0.4-0.3-0.30.20.2-0.30.3-0.00.10.20.40.6
Time to tail flick, vehicle, before self-admin0.10.10.4-0.5-0.3-0.2-0.6-0.3-0.2-0.2-0.1-0.6-0.10.6-0.0-0.4-0.4-0.1-0.20.20.1-0.3-0.4-0.2
Time to tail flick, vehicle, after self-admin1.21.72.9-0.9-1.3-1.5-0.6-1.2-1.6-1.5-1.51.21.5-1.71.51.21.2-1.10.9-1.31.11.31.11.0
Time to tail flick, test, before self-admin3.23.35.70.0-0.6-0.80.90.1-1.4-1.4-1.51.81.9-2.22.02.32.3-2.22.1-2.32.22.32.42.4
Time to tail flick, test, after self-admin0.30.31.80.30.30.30.50.3-0.0-0.0-0.00.50.3-1.30.30.60.6-0.60.4-0.50.80.40.50.7
Delta time to tail flick, vehicle, before/after SA1.21.12.4-0.1-0.6-0.90.3-0.3-1.0-1.0-1.01.21.2-1.51.31.31.3-1.01.0-1.21.01.31.21.1
Delta time to tail flick, test, before/after SA0.80.81.8-0.10.40.7-0.50.10.80.80.9-0.5-1.10.7-1.1-0.9-0.91.1-1.11.2-1.0-1.3-1.3-1.2
Tibia length1.85.08.52.82.92.82.12.22.82.82.8-1.9-2.41.7-2.4-1.9-1.91.9-1.91.9-1.9-1.9-1.4-1.3
Ambulatory time before self-admin0.10.10.3-0.2-0.4-0.6-0.3-0.5-0.4-0.3-0.3-0.40.20.60.2-0.5-0.50.3-0.10.0-0.20.1-0.1-0.2
Ambulatory time after self-admin2.02.37.1-0.3-0.10.0-1.1-0.50.60.70.8-1.9-1.32.7-1.2-1.9-1.91.9-1.91.8-1.6-1.7-2.1-2.0
Bone: tissue strength0.30.41.11.01.11.01.00.90.80.80.7-0.1-0.4-0.1-0.50.20.2-0.0-0.20.1-0.3-0.20.20.1
Total heroin consumption0.50.61.71.31.10.91.21.10.90.90.8-1.2-0.50.8-0.5-0.5-0.50.6-0.60.4-0.4-0.2-0.1-0.1
Bone: trabecular number1.32.14.3-0.6-0.00.2-1.2-0.50.70.80.8-1.7-1.41.8-1.4-1.8-1.81.8-1.91.8-1.9-1.7-2.0-2.1
Bone: trabecular spacing0.50.62.51.21.00.91.61.40.40.40.40.50.2-0.70.20.50.5-0.50.6-0.60.70.61.01.1
Bone: trabecular thickness3.84.79.5-0.50.30.7-1.6-0.71.41.41.5-2.1-2.32.4-2.3-2.4-2.42.6-2.72.8-2.7-2.8-3.0-3.1
Bone: trabecular tissue density0.20.20.6-0.2-0.0-0.0-0.4-0.20.20.20.2-0.0-0.40.5-0.4-0.4-0.40.8-0.80.6-0.8-0.7-0.6-0.8
Water consumed over 24 hours1.72.33.3-1.5-1.6-1.6-1.0-1.3-1.7-1.7-1.71.31.6-1.81.61.41.4-1.61.7-1.51.71.41.21.2
Number of responses in last shaping day0.00.00.2-0.0-0.3-0.5-0.1-0.4-0.3-0.2-0.20.20.2-0.10.3-0.0-0.0-0.0-0.2-0.1-0.10.30.10.0