Hub : Genes

Aebp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Aebp1 0.23 0.13 2.5e-09 0.17 0.16 0.1 0.16 1.8e-09 1.3e-08 4.4e-06 1.2e-08
2 Brain gene expression Aebp1 0.14 0.08 2.4e-15 0.17 0.16 0.16 0.17 6.0e-16 1.7e-14 1.9e-14 1.3e-15
3 Liver gene expression Aebp1 0.1 0.07 3.2e-08 0.06 0.05 0.06 0.05 1.2e-07 2.3e-06 8.9e-07 1.3e-06
4 pVTA gene expression Aebp1 0.05 0.04 1.4e-06 0.06 0.07 0.07 0.06 1.1e-05 1.1e-06 2.9e-06 5.8e-06
5 RMTg gene expression Aebp1 0.1 0.08 7.0e-03 0.01 0.04 -0.01 0.01 2.1e-01 3.4e-02 7.0e-01 1.4e-01
6 NAcc gene expression Aebp1 0.18 0.08 0.0e+00 0.27 0.26 0.27 0.27 1.3e-41 4.7e-40 4.6e-41 3.9e-41
7 Adipose gene expression Aebp1 0.22 0.13 4.7e-12 0.11 0.08 0.08 0.1 6.6e-12 1.2e-09 3.4e-09 3.7e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bone: apparent density0.00.10.30.50.20.2-0.3-0.20.10.3
Area under the delay curve2.43.64.6-2.1-1.7-1.91.92.1-1.8-1.7
BMI with tail0.10.30.5-0.4-0.7-0.30.60.6-0.7-0.6
BMI without tail0.21.11.5-1.0-1.1-0.81.11.2-1.0-1.1
Body weight1.66.88.0-2.7-2.6-2.32.72.8-2.7-2.5
Weight adjusted by age0.10.30.5-0.6-0.5-0.70.60.6-0.7-0.4
Bone surface0.20.30.6-0.3-0.7-0.80.50.4-0.8-0.4
Bone volume0.10.30.5-0.2-0.7-0.70.50.4-0.7-0.4
Breakpoint value in progressive ratio session0.20.40.5-0.7-0.7-0.70.70.7-0.6-0.5
Number of licking bursts1.13.43.7-1.9-1.8-1.91.81.8-1.9-1.8
Context. condit. distance diff. score3.44.15.02.21.92.2-2.1-2.11.91.8
Locomotion velocity, session 10.10.10.2-0.4-0.2-0.3-0.2-0.3-0.20.3
Locomotion distance, session 10.50.71.01.00.90.9-0.7-0.40.90.9
Locomotion velocity, session 20.10.10.2-0.2-0.4-0.4-0.0-0.3-0.4-0.2
Locomotion distance, session 21.01.52.51.61.11.3-1.2-1.01.21.0
Locomotion velocity, session 32.12.43.71.91.31.6-1.6-1.51.31.6
Locomotion distance, session 30.50.61.10.2-1.1-0.50.70.6-1.0-0.8
Stereotopy head waving bouts, day 30.70.91.21.11.11.0-0.8-0.71.00.7
Stereotopy head waving duration, day 32.43.03.61.51.91.7-1.7-1.71.91.6
Locomotion velocity, session 70.30.30.5-0.3-0.7-0.40.50.4-0.7-0.5
Locomotion distance, session 70.10.10.40.60.10.4-0.3-0.40.10.2
Stereotopy head waving bouts, day 70.10.10.2-0.00.40.0-0.4-0.40.40.3
Stereotopy head waving duration, day 70.10.10.1-0.00.4-0.0-0.2-0.20.30.3
Locomotion velocity, session 81.01.21.91.30.71.1-1.2-1.40.71.0
Locomotion distance, session 86.910.012.23.52.93.4-3.2-3.23.02.9
Degree of sensitization distance2.42.63.31.11.61.5-1.7-1.81.71.7
Degree of sensitization stereotypy0.10.10.3-0.5-0.1-0.30.10.1-0.1-0.1
Conditioned locomotion1.01.22.11.51.11.3-0.9-0.51.01.1
Cocaine response after cond. corrected1.11.62.5-1.6-1.1-1.31.31.3-1.0-1.2
Cocaine response after cond. not corrected1.11.72.6-1.6-1.1-1.31.31.4-1.1-1.2
Cocaine response before conditioning0.40.40.60.80.70.7-0.6-0.50.60.7
Saline control response0.30.40.90.90.50.6-0.6-0.60.40.5
Bone: connectivity density0.20.20.40.70.40.4-0.5-0.50.40.5
Bone: cortical apparent density0.60.91.4-1.2-1.0-1.00.90.8-1.0-0.9
Bone: cortical area2.23.54.1-1.8-2.0-1.81.92.0-2.0-1.6
Bone: cortical porosity0.00.00.1-0.3-0.00.00.10.0-0.2-0.1
Bone: cortical porosity0.20.20.30.30.50.6-0.4-0.40.40.4
Bone: cortical thickness1.52.53.1-1.4-1.7-1.51.61.7-1.8-1.3
Bone: cortical thickness0.81.01.31.11.01.1-0.9-0.71.01.1
Bone: cortical tissue density0.61.01.5-1.2-1.0-1.00.90.9-1.1-0.9
Condit. Reinf. active minus inactive responses1.21.32.1-0.9-1.2-1.01.21.1-1.2-1.5
Condit. Reinf. active-inactive response ratio0.10.10.2-0.3-0.2-0.10.1-0.3-0.2-0.5
Condit. Reinf. active responses0.60.81.1-0.6-1.0-0.81.00.9-1.0-1.1
Condit. Reinf. inactive responses0.30.40.8-0.1-0.7-0.50.70.9-0.6-0.5
Incentive salience index mean1.62.12.9-1.0-1.5-1.21.61.6-1.4-1.7
Condit. Reinf. lever presses0.50.71.6-0.3-0.8-0.61.01.3-0.8-0.8
Condit. Reinf. active minus inactive responses0.30.50.80.90.80.7-0.7-0.60.70.7
Condit. Reinf. active-inactive response ratio0.00.00.00.20.10.10.10.20.0-0.1
Condit. Reinf. active responses0.60.81.01.01.00.9-0.9-0.80.90.9
Condit. Reinf. inactive responses0.71.11.50.91.00.9-1.1-1.21.01.1
Condit. Reinf. lever presses0.40.60.90.90.80.8-0.7-0.70.70.7
Condit. Reinf. lever reinforcers received0.40.60.80.80.90.7-0.7-0.70.70.8
Conditioned reinforcement - actives0.00.20.3-0.4-0.5-0.50.40.4-0.3-0.0
Conditioned reinforcement - inactives0.30.81.1-1.0-1.1-1.00.80.8-0.9-0.5
Conditioned locomotion0.71.01.5-0.8-1.1-1.01.11.2-1.0-0.8
Patch foraging indifference point 0 sec1.13.14.4-1.8-1.9-1.61.71.4-1.7-2.1
Patch foraging indifference point AUC0.00.10.2-0.4-0.3-0.30.20.1-0.4-0.2
Delay disc. indifference point, 0s delay0.91.01.9-1.4-0.9-1.00.91.0-0.9-0.8
Delay disc. indifference point, 16s delay1.62.32.5-1.6-1.5-1.51.51.6-1.5-1.5
Delay disc. indifference point, 2s delay1.31.42.5-1.3-0.9-1.11.31.6-0.9-1.2
Delay disc. indifference point, 24s delay1.11.72.0-1.2-1.3-1.31.31.4-1.2-1.4
Delay disc. indifference point, 4s delay3.03.24.5-1.9-1.6-1.71.92.1-1.6-1.7
Delay disc. indifference point, 8s delay0.71.21.7-1.3-0.9-1.11.11.3-1.0-0.8
Indifference point function ln k0.00.00.10.3-0.00.00.10.20.00.1
Indifference point function log k0.00.00.10.3-0.00.00.10.20.00.1
Patch foraging total patch changes 0 sec1.13.24.6-1.8-1.9-1.71.81.4-1.7-2.1
Patch foraging total patch changes 12 sec1.11.52.0-1.3-1.3-1.01.10.9-1.3-1.4
Patch foraging total patch changes 18 sec1.02.43.4-1.8-1.6-1.61.51.1-1.5-1.7
Patch foraging total patch changes 24 sec0.31.11.91.10.91.1-1.1-1.41.00.5
Patch foraging total patch changes 6 sec2.03.44.5-1.7-2.0-1.81.81.5-1.8-2.1
Patch foraging time to switch 0 sec0.20.81.20.81.01.0-0.8-0.71.10.8
Patch foraging water rate 0 sec0.93.54.1-1.8-2.0-1.91.81.6-2.0-1.9
Patch foraging water rate 12 sec0.00.20.3-0.1-0.6-0.40.40.4-0.5-0.4
Patch foraging water rate 18 sec0.10.10.30.30.50.5-0.10.20.40.2
Patch foraging water rate 24 sec0.10.10.1-0.4-0.2-0.40.20.3-0.4-0.2
Patch foraging water rate 6 sec0.30.50.8-0.5-0.6-0.80.70.9-0.6-0.5
Seeking ratio, delayed vs. immediate footshock0.10.20.50.10.70.4-0.20.10.70.3
Distance traveled before self-admin0.00.10.2-0.5-0.4-0.20.20.2-0.2-0.3
Distance traveled after self-admin0.00.00.10.0-0.10.10.10.30.2-0.1
Extensor digitorum longus weight3.212.713.4-3.5-3.5-3.53.73.6-3.6-3.5
Bone: elastic displacement0.50.71.20.50.81.1-0.8-0.80.80.7
Bone: elastic work0.00.10.1-0.3-0.10.20.20.3-0.1-0.3
Bone: endosteal estimation0.00.00.1-0.30.0-0.20.10.20.0-0.2
Bone: endosteal perimeter0.40.91.4-1.2-0.7-1.01.01.2-0.7-0.7
Epididymis fat weight0.31.31.7-1.0-1.2-1.11.21.3-1.1-1.1
Delta time in closed arm before/after self-admin10.39.710.82.73.33.2-3.1-2.93.33.3
Delta time in open arm before/after self-admin6.37.59.0-3.0-2.8-2.62.72.5-2.8-2.7
Diff in mean of infusions in LGA sessions0.00.10.10.20.30.4-0.2-0.10.40.3
Delay discount exponential model param2.63.54.42.01.71.9-1.9-2.11.71.7
Extinction: sum of active levers before priming0.10.10.1-0.3-0.4-0.30.40.3-0.2-0.3
Active lever presses in extinction session 60.20.20.60.20.50.5-0.4-0.20.50.7
Bone: final force0.30.40.6-0.5-0.7-0.60.70.6-0.6-0.8
Bone: final moment0.40.60.9-0.7-0.9-0.70.80.7-0.8-0.9
Food consumed during 24 hour testing period1.32.73.3-1.6-1.7-1.71.61.4-1.8-1.7
Glucose18.329.035.7-5.8-5.8-6.04.93.9-5.7-5.2
Heart weight0.30.50.9-0.3-0.9-0.60.60.3-0.9-0.9
Delay discount hyperbolic model param2.73.54.62.01.71.8-1.9-2.21.71.7
Intermittent access intake day 1-15 change0.31.52.0-1.1-1.4-1.21.21.0-1.3-1.3
Intermittent access intake escalation0.31.41.9-0.9-1.4-1.11.21.0-1.3-1.2
Intermittent access intake escalation 20.30.50.8-0.4-0.9-0.60.60.4-0.8-0.8
Intermitt. access day 1 inactive lever presses0.00.20.5-0.00.60.4-0.5-0.40.60.7
Intermitt. access day 15 inactive lever presses0.53.03.4-1.7-1.7-1.81.81.6-1.7-1.6
Intermitt. access escalation Index0.10.20.4-0.3-0.5-0.40.40.1-0.6-0.6
Intermittent access day 1 total infusions0.00.00.1-0.4-0.1-0.20.10.3-0.00.2
Intermittent access day 15 total infusions0.92.32.8-1.5-1.7-1.51.51.4-1.6-1.3
Intermittent access terminal intake (last 3 days)0.50.91.4-0.8-1.2-1.01.00.8-1.0-0.9
Intermittent access total infusions0.80.91.2-1.0-1.1-0.91.01.0-1.0-0.8
Intermittent access day 1 locomotion0.10.20.70.30.40.3-0.4-0.10.40.9
Intermittent access day 15 total locomotion0.31.11.4-1.1-1.0-1.11.11.2-0.9-0.8
Intermittent access total locomotion0.91.11.5-1.0-1.2-1.01.11.2-1.1-0.9
Intermittent access standard deviation0.20.91.30.90.90.7-1.0-1.11.01.0
Left kidney weight0.00.20.4-0.6-0.2-0.10.40.7-0.2-0.2
Right kidney weight0.00.10.20.10.00.40.10.4-0.10.1
Cocaine induced anxiety1.64.45.5-1.7-2.4-2.12.12.0-2.4-2.1
Post-drug Anxiety3.03.43.9-1.5-2.0-1.91.91.8-2.0-1.8
Baseline Anxiety0.10.20.50.10.70.2-0.4-0.20.70.4
Tail length1.89.911.6-3.0-3.1-2.93.33.4-3.1-3.1
Length with tail2.310.111.8-3.1-3.1-3.03.33.4-3.2-3.1
Length without tail0.21.11.5-0.7-1.0-1.01.21.2-1.2-1.1
Times rat made contact with spout0.20.20.5-0.3-0.6-0.4-0.1-0.7-0.7-0.1
Lifetime Intake0.50.70.9-0.9-0.9-0.80.90.9-0.8-0.6
Liver weight, left0.40.71.00.80.80.8-0.9-0.70.71.0
Liver weight, right1.22.23.21.41.51.4-1.5-1.21.51.8
Locomotor activity0.50.81.4-1.2-0.8-1.10.80.5-0.8-1.0
Locomotor testing distance0.20.40.5-0.7-0.4-0.70.70.7-0.4-0.7
Locomotor testing rearing0.83.03.7-1.8-1.7-1.91.71.5-1.6-1.8
Locomotion in novel chamber3.34.45.42.01.92.1-2.2-2.21.92.3
Locomotion in novel chamber post-restriction1.13.33.91.71.81.7-1.9-1.81.82.0
Fecal boli incidents, locomotor time 10.10.20.40.50.60.1-0.3-0.30.50.3
Change in fecal boli incidents, locomotor task0.20.20.3-0.5-0.6-0.60.40.2-0.5-0.3
Time >=10cm from walls, locomotor time 10.10.10.4-0.10.3-0.2-0.4-0.50.30.6
Bouts of movement, locomotor time 10.30.40.7-0.7-0.7-0.80.60.3-0.8-0.6
Total resting periods, locomotor time 10.10.10.2-0.2-0.3-0.40.30.1-0.3-0.3
Rest time, locomotor task time 10.00.00.1-0.0-0.0-0.40.1-0.0-0.20.1
Distance moved, locomotor task time 10.10.30.5-0.6-0.5-0.40.60.7-0.4-0.7
Vertical activity count, locomotor time 10.00.10.3-0.6-0.4-0.20.30.3-0.3-0.3
Time >=10cm from walls, locomotor time 20.20.51.1-0.01.00.3-0.7-0.50.81.0
Bouts of movement, locomotor time 20.10.31.00.20.10.20.61.00.1-0.6
Total resting periods, locomotor time 20.10.31.10.20.00.00.71.0-0.1-0.8
Rest time, locomotor task time 20.10.10.30.50.50.1-0.2-0.30.40.1
Distance moved, locomotor task time 20.10.10.20.00.30.2-0.4-0.30.20.4
Vertical activity count, locomotor time 20.10.10.5-0.10.20.1-0.5-0.40.00.7
Light reinforcement 10.00.20.3-0.2-0.5-0.30.40.5-0.3-0.4
Light reinforcement 20.00.10.4-0.4-0.1-0.10.20.60.00.1
Bone: marrow area0.00.00.0-0.20.2-0.10.00.10.1-0.0
Bone: maximum diameter3.97.88.7-2.9-2.7-2.92.82.7-2.9-2.6
Bone: maximum force0.10.30.3-0.4-0.6-0.50.50.5-0.5-0.5
Bone: maximum moment0.20.40.5-0.6-0.7-0.60.70.7-0.6-0.7
Mean time between licks in bursts0.10.81.2-1.0-1.0-1.10.80.6-0.9-0.8
Mean num. licks in bursts0.82.13.91.41.11.3-1.6-2.01.21.4
Cd content in liver0.60.70.9-0.8-0.7-0.90.90.7-0.8-1.0
Co content in liver0.40.51.1-0.6-0.3-0.60.80.8-0.4-1.1
Cu content in liver0.20.30.4-0.6-0.5-0.60.50.3-0.5-0.5
Fe content in liver1.72.12.41.51.41.5-1.5-1.41.41.5
K content in liver1.41.32.3-1.1-1.0-1.21.21.5-1.0-0.9
Mg content in liver0.30.30.5-0.5-0.5-0.70.60.6-0.5-0.5
Mn content in liver0.20.20.4-0.1-0.4-0.30.50.6-0.4-0.3
Na content in liver2.52.83.1-1.7-1.7-1.81.71.7-1.7-1.6
Rb content in liver1.61.82.4-1.4-1.2-1.61.41.3-1.2-1.2
Se content in liver1.01.21.9-0.6-1.2-1.01.21.4-1.2-1.1
Sr content in liver4.64.04.2-2.0-2.0-2.02.02.0-2.0-2.0
Zn content in liver0.30.40.9-0.6-0.4-0.60.71.0-0.4-0.5
Bone: minimum diameter0.00.10.20.30.30.3-0.2-0.10.20.4
Time in familiar zone, hab. session 10.10.10.50.70.10.4-0.2-0.20.10.3
Time in novel zone, hab. session 10.20.30.7-0.8-0.4-0.60.40.3-0.5-0.5
Total zone transitions, hab. session 10.10.10.2-0.2-0.5-0.40.20.2-0.4-0.1
Total locomotion distance, hab. session 10.10.20.4-0.2-0.5-0.40.40.6-0.5-0.2
Locomotion velocity, hab. session 10.00.00.1-0.1-0.3-0.20.10.2-0.20.1
Time in familiar zone, hab. session 21.82.13.21.31.41.8-1.4-1.41.51.2
Time in novel zone, hab. session 22.72.94.2-1.5-1.8-2.01.61.5-1.8-1.5
Total zone transitions, hab. session 21.01.31.7-0.9-1.2-1.21.11.3-1.2-1.0
Total locomotion distance, hab. session 21.31.62.2-0.9-1.4-1.21.31.5-1.4-1.2
Locomotion velocity, hab. session 21.51.92.9-1.1-1.5-1.31.41.7-1.5-1.3
Novel to familiar place preference ratio0.60.81.5-1.2-0.9-1.10.70.5-0.9-0.6
Novelty place preference0.70.91.7-1.3-1.0-1.20.70.5-1.0-0.6
Time in novel zone, NPP test0.70.81.5-1.2-1.0-1.20.70.4-1.0-0.6
Total zone transitions, NPP test0.30.51.21.10.60.7-0.5-0.20.60.6
Total locomotion distance, NPP test0.10.10.30.50.10.4-0.00.30.10.2
Locomotion velocity, NPP test0.00.10.30.3-0.10.20.20.5-0.10.0
Intraocular pressure0.30.50.7-0.8-0.6-0.80.70.7-0.8-0.6
Delta distance traveled before/after self-admin0.60.70.90.90.90.8-0.8-0.60.90.9
Delta ambulatory time before/after self-admin0.40.70.90.90.90.8-0.8-0.60.90.8
Parametrial fat weight2.55.96.5-2.5-2.5-2.52.42.2-2.5-2.4
Pavlov. Cond. lever latency0.20.20.7-0.8-0.4-0.50.40.2-0.4-0.5
Pavlov. Cond. magazine entry latency2.22.84.52.11.51.8-1.6-1.61.51.5
Pavlov. Cond. change in total contacts1.51.72.2-0.7-1.3-1.21.41.4-1.4-1.5
Pavlov. Cond. index score1.72.24.42.11.41.6-1.3-1.21.31.3
Pavlov. Cond. latency score1.41.83.41.91.31.5-1.2-1.01.21.2
Pavlov. Cond. lever contacts0.50.71.81.30.70.9-0.6-0.40.70.7
Pavlov. Cond. magazine entry number1.92.44.9-2.2-1.3-1.61.41.5-1.3-1.2
Pavlov. Cond. intertrial magazine entries0.30.31.0-0.8-0.3-0.30.61.0-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.2.12.65.22.31.51.8-1.5-1.31.51.4
Pavlov. Cond. response bias0.80.92.81.70.81.0-0.8-0.60.70.7
Pavlov. Cond. lever latency3.04.25.8-2.0-2.0-2.02.22.4-1.8-1.8
Pavlov. Cond. magazine entry latency0.00.10.10.30.30.0-0.3-0.30.20.3
Pavlov. Cond. change in total contacts0.10.20.40.40.60.3-0.6-0.60.50.5
Pavlov. Cond. index score0.91.41.91.21.21.0-1.3-1.41.01.1
Pavlov. Cond. latency score1.11.72.11.41.31.2-1.4-1.41.21.2
Pavlov. Cond. lever contacts3.34.86.42.22.22.1-2.3-2.52.02.0
Pavlov. Cond. magazine entry number0.10.10.3-0.1-0.10.10.30.6-0.0-0.1
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.0-0.30.10.30.3-0.3-0.2
Pavlov. Cond. lever-magazine prob. diff.1.11.62.21.31.31.1-1.4-1.51.11.2
Pavlov. Cond. response bias1.52.13.51.31.51.3-1.6-1.91.31.3
Time in closed arm before self-admin0.10.20.4-0.4-0.5-0.40.50.5-0.4-0.6
Time in closed arm after self-admin2.73.13.71.71.91.9-1.7-1.51.91.6
Time in open arm before self-admin0.81.01.70.91.00.9-1.0-0.91.01.3
Time in open arm after self-admin0.70.81.1-1.1-1.0-0.90.80.7-0.9-0.7
Bone: periosteal estimation0.51.11.5-1.2-1.0-1.11.11.1-1.1-0.9
Bone: periosteal perimeter1.22.32.9-1.7-1.5-1.51.51.7-1.5-1.2
Bone: post-yield work0.00.10.2-0.2-0.3-0.40.20.2-0.2-0.0
Progressive ratio test 1 active lever presses0.20.40.7-0.8-0.6-0.70.70.8-0.4-0.6
Progressive ratio test 1 breakpoint0.30.50.8-0.7-0.6-0.70.70.9-0.4-0.6
Progressive ratio test 1 inactive lever presses2.25.87.3-2.6-2.3-2.42.52.7-2.2-2.1
Progressive ratio test 2 active lever presses0.50.71.1-0.9-1.0-0.80.80.8-0.8-0.7
Progressive ratio test 2 breakpoint0.50.61.0-0.8-1.0-0.70.80.7-0.7-0.6
Progressive ratio test 2 inactive lever presses0.51.72.2-1.3-1.3-1.31.31.5-1.2-1.1
Incentive Sensitization - Responses0.10.30.5-0.5-0.7-0.50.50.5-0.6-0.4
Incentive Sensitization - Breakpoint0.10.20.4-0.4-0.6-0.40.40.4-0.5-0.3
Sum of active levers in priming session hrs 5-60.50.50.7-0.6-0.8-0.60.70.8-0.7-0.7
Progressive ratio0.10.20.50.30.30.7-0.4-0.30.30.4
Food seeking constrained by brief footshock2.53.24.5-1.9-1.8-1.61.82.1-1.8-1.5
Seeking ratio, punishment vs. effort0.61.42.0-1.0-1.0-1.21.31.4-1.0-1.1
Retroperitoneal fat weight0.62.62.9-1.5-1.6-1.61.71.6-1.6-1.7
Reaction time number correct0.00.00.2-0.0-0.3-0.40.20.0-0.1-0.2
Reaction time mean minus median0.31.93.21.01.41.1-1.5-1.81.41.3
Reaction time mean minus median AUC0.21.62.80.91.31.0-1.4-1.71.31.3
Reaction time num false alarms0.30.51.00.1-0.7-0.20.81.0-0.6-0.9
Reaction time num false alarms AUC0.20.40.80.3-0.50.00.70.9-0.5-0.8
Reaction time trials correct on left0.00.00.2-0.0-0.3-0.40.20.0-0.1-0.2
Reaction time trials on left0.00.00.10.0-0.2-0.30.1-0.0-0.1-0.2
Reaction time mean0.51.01.40.61.21.0-1.0-1.01.10.9
Reaction time mean AUC0.71.62.20.91.51.3-1.3-1.31.41.2
Median of all reaction times0.40.60.90.40.90.8-0.7-0.60.90.7
Reaction time omissions1.22.02.71.41.51.5-1.3-1.41.61.0
Reaction time false alarm rate0.20.30.80.3-0.40.10.60.9-0.4-0.6
Reaction time premature initiation rate2.43.84.11.92.02.0-1.9-1.81.92.0
Reaction time premature initiations0.72.02.21.51.51.3-1.4-1.41.41.5
Std. dev. reaction times0.51.82.50.91.51.3-1.4-1.61.41.2
Reaction time trials completed0.00.00.10.0-0.2-0.30.1-0.0-0.1-0.2
Reaction time trials AUC0.00.10.2-0.1-0.3-0.50.20.1-0.2-0.3
Run reversals in cocaine runway, females0.60.60.90.90.70.9-0.7-0.50.90.7
Run reversals in cocaine runway, males0.30.30.7-0.8-0.5-0.60.50.5-0.5-0.4
Latency to leave start box in cocaine runway0.10.20.5-0.4-0.30.00.50.6-0.1-0.7
Latency to leave start box in cocaine runway, F0.91.21.5-1.1-1.1-0.91.11.2-0.8-1.2
Latency to leave start box in cocaine runway, M0.60.61.30.70.81.1-0.6-0.50.90.4
Std. dev. time between licks in bursts0.00.00.00.1-0.1-0.10.0-0.0-0.0-0.1
Total sessions with >9 infusions1.01.31.81.01.11.0-1.1-1.11.21.4
Short access day 1 total inactive lever presses2.14.36.0-2.4-2.0-1.92.02.1-2.1-1.8
Short access day 10 total inactive lever presses0.00.20.4-0.6-0.4-0.40.40.5-0.6-0.2
Short access day 1 total infusions0.50.91.40.61.00.9-0.9-0.81.11.2
Short access day 10 total infusions0.30.51.00.50.70.6-0.7-0.60.81.0
Short access total infusions0.00.00.1-0.00.10.1-0.1-0.10.20.3
Short access day 1 locomotion0.81.42.21.21.21.0-1.1-0.81.31.5
Short access day 10 total locomotion0.41.52.30.91.41.1-1.3-0.91.31.5
Short access total locomotion1.31.92.71.21.51.3-1.4-1.21.41.6
One hour access (0.3 mA shock)1.01.21.7-1.0-1.3-1.01.11.1-1.1-0.9
Compulsive drug intake1.52.22.81.41.41.7-1.5-1.51.21.5
One hour access (shock baseline)0.51.41.7-1.3-1.3-1.21.21.2-1.0-1.0
Social response proportion1.51.92.4-1.4-1.4-1.51.31.3-1.6-1.1
Social responses2.33.13.4-1.7-1.7-1.91.81.7-1.8-1.8
Social time0.10.20.5-0.4-0.3-0.30.50.5-0.4-0.7
Soleus weight0.51.52.7-1.5-1.0-1.01.31.6-1.0-1.0
Bone: stiffness0.00.10.20.20.20.1-0.3-0.30.30.4
Tibialis anterior weight1.13.94.5-1.9-2.0-1.82.01.9-2.1-2.0
Time to tail flick, vehicle, before self-admin0.00.00.2-0.0-0.10.00.20.5-0.2-0.1
Time to tail flick, vehicle, after self-admin0.10.10.40.60.30.5-0.20.00.4-0.1
Time to tail flick, test, before self-admin0.10.10.40.10.30.2-0.4-0.60.30.3
Time to tail flick, test, after self-admin2.72.94.1-1.5-1.7-1.61.92.0-1.6-1.5
Delta time to tail flick, vehicle, before/after SA0.20.30.40.40.60.4-0.5-0.50.60.4
Delta time to tail flick, test, before/after SA1.41.72.6-1.0-1.3-1.21.41.6-1.3-1.2
Tibia length0.20.50.90.70.90.9-0.5-0.20.90.6
Ambulatory time before self-admin0.20.50.9-0.9-0.8-0.60.70.6-0.6-0.7
Ambulatory time after self-admin0.00.00.0-0.1-0.00.10.00.20.20.0
Bone: tissue strength0.10.10.2-0.4-0.0-0.3-0.1-0.40.0-0.1
Total heroin consumption0.00.00.20.5-0.00.2-0.0-0.00.20.0
Bone: trabecular number0.00.00.10.30.20.2-0.2-0.20.20.2
Bone: trabecular spacing1.01.41.7-1.3-1.2-1.21.21.1-1.2-1.1
Bone: trabecular thickness1.11.52.41.51.31.3-1.1-0.91.21.2
Bone: trabecular tissue density0.20.30.70.40.40.4-0.7-0.90.40.6
Water consumed over 24 hours0.81.52.1-1.3-1.4-1.41.10.8-1.5-1.2
Number of responses in last shaping day0.10.20.40.40.30.6-0.3-0.10.70.5