Hub : Genes

Aebp1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Aebp1 0.24 0.13 7.7e-10 0.19 0.18 0.17 0.18 3.3e-10 5.6e-10 1.2e-09 9.4e-10
2 Adipose isoform ratio NM_001100970.1 0.02 0.02 4.3e-03 0.01 0.01 0 0 3.2e-02 4.2e-02 2.0e-01 1.1e-01
3 Adipose isoform ratio XM_006251316.4 0.02 0.02 3.5e-03 0.01 0.01 0 0 2.8e-02 3.5e-02 2.1e-01 1.0e-01
4 Brain gene expression Aebp1 0.15 0.09 1.2e-15 0.19 0.16 0.17 0.17 4.9e-17 6.6e-15 1.4e-15 4.4e-16
5 NAcc gene expression Aebp1 0.15 0.07 0.0e+00 0.22 0.21 0.22 0.22 5.9e-25 7.5e-24 8.8e-25 6.0e-25
6 Liver gene expression Aebp1 0.1 0.08 9.9e-08 0.06 0.04 0.04 0.05 1.6e-07 1.0e-05 2.5e-05 3.4e-06
7 RMTg gene expression Aebp1 0.11 0.08 3.3e-03 0.03 0.05 0.01 0.03 5.3e-02 1.5e-02 1.7e-01 4.6e-02
8 Adipose gene expression Aebp1 0.23 0.13 4.5e-12 0.11 0.08 0.08 0.1 8.3e-12 1.5e-09 1.5e-09 2.9e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.00.10.20.50.2-0.20.20.20.3-0.10.2
Area under the delay curve3.33.54.7-2.1-1.81.8-1.7-1.7-1.82.2-1.8
BMI with tail0.00.00.0-0.1-0.00.0-0.1-0.10.20.2-0.2
BMI without tail0.00.10.30.30.2-0.20.10.10.5-0.1-0.1
Body weight1.35.57.2-2.7-2.22.2-2.3-2.3-2.02.6-2.3
Weight adjusted by age0.40.50.7-0.9-0.70.7-0.7-0.7-0.70.7-0.5
Bone surface0.40.60.9-0.5-1.01.0-0.9-0.9-0.80.6-0.6
Bone volume0.30.50.7-0.4-0.80.8-0.8-0.8-0.70.6-0.7
Breakpoint value in progressive ratio session1.31.41.7-1.2-1.21.2-1.3-1.3-1.11.2-1.1
Number of licking bursts3.23.74.1-2.0-2.02.0-1.9-1.9-1.91.9-1.8
Context. condit. distance diff. score3.94.75.52.32.2-2.22.12.12.3-2.21.8
Locomotion velocity, session 10.10.10.3-0.6-0.20.2-0.2-0.2-0.3-0.30.2
Locomotion distance, session 10.60.81.01.00.8-0.81.01.00.9-0.41.0
Locomotion velocity, session 20.10.10.3-0.3-0.40.4-0.4-0.4-0.5-0.3-0.2
Locomotion distance, session 20.91.32.41.61.0-1.01.11.11.1-1.01.1
Locomotion velocity, session 31.92.23.81.91.5-1.51.31.31.5-1.51.5
Locomotion distance, session 30.50.60.90.1-0.70.7-1.0-1.0-0.60.7-0.8
Stereotopy head waving bouts, day 30.81.01.31.11.0-1.01.11.11.0-0.80.8
Stereotopy head waving duration, day 32.22.73.21.41.6-1.61.81.81.7-1.61.6
Locomotion velocity, session 70.30.30.5-0.4-0.50.5-0.7-0.7-0.60.4-0.6
Locomotion distance, session 70.10.10.40.60.5-0.50.10.10.3-0.50.2
Stereotopy head waving bouts, day 70.70.71.00.60.8-0.80.90.90.8-1.01.0
Stereotopy head waving duration, day 70.10.10.10.10.2-0.20.40.40.3-0.20.4
Locomotion velocity, session 80.91.11.91.21.0-1.00.90.90.9-1.40.9
Locomotion distance, session 87.410.913.03.63.4-3.43.23.23.4-3.33.0
Degree of sensitization distance2.52.53.31.21.7-1.71.61.61.5-1.81.6
Degree of sensitization stereotypy0.00.00.1-0.4-0.10.1-0.0-0.0-0.00.00.0
Conditioned locomotion1.11.32.01.41.2-1.21.21.21.2-0.61.0
Cocaine response after cond. corrected1.31.52.2-1.5-1.21.2-1.1-1.1-1.31.2-1.1
Cocaine response after cond. not corrected1.41.52.5-1.6-1.21.2-1.0-1.0-1.21.3-1.1
Cocaine response before conditioning0.40.50.60.60.7-0.70.70.70.8-0.50.8
Saline control response0.40.50.91.00.7-0.70.60.60.7-0.80.5
Bone: connectivity density0.10.20.50.70.4-0.40.40.40.4-0.50.4
Bone: cortical apparent density0.71.01.2-1.1-0.90.9-1.1-1.1-0.90.9-0.9
Bone: cortical area3.24.85.4-2.1-2.22.2-2.3-2.3-2.12.2-1.9
Bone: cortical porosity0.00.00.0-0.1-0.10.10.00.00.10.2-0.1
Bone: cortical porosity0.20.20.40.50.4-0.40.50.50.6-0.30.4
Bone: cortical thickness2.03.33.9-1.6-1.81.8-2.0-2.0-1.81.9-1.6
Bone: cortical thickness0.50.60.90.90.7-0.70.70.70.8-0.50.8
Bone: cortical tissue density0.81.01.3-1.2-1.01.0-1.1-1.1-0.90.9-1.0
Condit. Reinf. active minus inactive responses1.21.32.2-1.0-1.11.1-1.2-1.2-1.01.1-1.5
Condit. Reinf. active-inactive response ratio0.10.10.3-0.3-0.20.2-0.2-0.2-0.2-0.2-0.5
Condit. Reinf. active responses0.60.81.2-0.6-0.80.8-1.0-1.0-0.80.9-1.1
Condit. Reinf. inactive responses0.30.40.7-0.1-0.50.5-0.7-0.7-0.60.9-0.6
Incentive salience index mean1.61.93.0-1.1-1.31.3-1.4-1.4-1.31.5-1.7
Condit. Reinf. lever presses0.40.61.4-0.3-0.70.7-0.8-0.8-0.71.2-0.8
Condit. Reinf. active minus inactive responses0.40.50.60.70.8-0.80.80.80.6-0.60.6
Condit. Reinf. active-inactive response ratio0.00.00.00.10.2-0.20.10.1-0.00.2-0.1
Condit. Reinf. active responses0.50.80.90.80.9-0.91.01.00.8-0.80.9
Condit. Reinf. inactive responses0.81.01.40.80.9-0.91.01.01.0-1.21.1
Condit. Reinf. lever presses0.40.50.70.90.7-0.70.70.70.7-0.70.7
Condit. Reinf. lever reinforcers received0.40.60.70.80.8-0.80.90.90.7-0.70.8
Conditioned reinforcement - actives0.00.00.10.3-0.00.0-0.1-0.10.10.00.0
Conditioned reinforcement - inactives0.00.00.1-0.2-0.30.3-0.3-0.3-0.20.2-0.2
Conditioned locomotion0.00.00.10.3-0.10.1-0.1-0.10.10.3-0.1
Patch foraging indifference point 0 sec1.82.84.1-1.7-1.61.6-1.8-1.8-1.51.4-2.0
Patch foraging indifference point AUC0.20.20.3-0.4-0.60.6-0.5-0.5-0.40.2-0.4
Delay disc. indifference point, 0s delay0.80.91.7-1.3-0.90.9-0.8-0.8-1.00.9-0.8
Delay disc. indifference point, 16s delay2.72.83.2-1.8-1.61.6-1.7-1.7-1.61.7-1.7
Delay disc. indifference point, 2s delay0.80.92.0-1.1-0.80.8-0.7-0.7-1.01.4-1.0
Delay disc. indifference point, 24s delay1.71.61.9-1.2-1.21.2-1.3-1.3-1.31.4-1.4
Delay disc. indifference point, 4s delay2.93.04.5-1.9-1.61.6-1.6-1.6-1.72.1-1.7
Delay disc. indifference point, 8s delay1.11.21.8-1.3-1.11.1-0.9-0.9-1.01.3-0.9
Indifference point function ln k0.00.00.00.20.0-0.00.00.00.00.20.1
Indifference point function log k0.00.00.00.20.0-0.00.00.00.00.20.1
Patch foraging total patch changes 0 sec1.93.14.5-1.7-1.71.7-1.9-1.9-1.61.5-2.1
Patch foraging total patch changes 12 sec1.21.52.0-1.3-1.21.2-1.3-1.3-1.10.9-1.4
Patch foraging total patch changes 18 sec2.12.73.2-1.8-1.71.7-1.7-1.7-1.51.2-1.8
Patch foraging total patch changes 24 sec0.70.91.51.01.0-1.00.80.81.0-1.20.5
Patch foraging total patch changes 6 sec2.33.44.5-1.7-1.91.9-1.9-1.9-1.71.5-2.1
Patch foraging time to switch 0 sec0.71.01.40.81.2-1.21.11.11.0-0.80.9
Patch foraging water rate 0 sec2.23.54.1-1.7-1.91.9-2.0-2.0-1.81.6-2.0
Patch foraging water rate 12 sec0.10.20.3-0.2-0.50.5-0.5-0.5-0.40.4-0.5
Patch foraging water rate 18 sec0.10.20.30.20.5-0.50.50.50.40.20.2
Patch foraging water rate 24 sec0.10.10.1-0.4-0.30.3-0.2-0.2-0.30.3-0.2
Patch foraging water rate 6 sec0.30.50.8-0.6-0.60.6-0.7-0.7-0.80.9-0.5
Seeking ratio, delayed vs. immediate footshock0.60.61.00.41.0-1.01.01.00.7-0.20.7
Distance traveled before self-admin0.20.20.4-0.7-0.30.3-0.6-0.6-0.30.2-0.4
Distance traveled after self-admin0.20.20.4-0.4-0.10.1-0.5-0.5-0.20.6-0.5
Extensor digitorum longus weight3.313.114.0-3.6-3.73.7-3.5-3.5-3.53.6-3.6
Bone: elastic displacement0.80.91.30.91.0-1.01.01.01.2-0.90.8
Bone: elastic work0.00.00.10.00.2-0.20.10.10.30.2-0.2
Bone: endosteal estimation0.00.10.3-0.6-0.20.2-0.2-0.2-0.10.3-0.3
Bone: endosteal perimeter0.51.11.8-1.3-1.01.0-0.9-0.9-1.01.2-0.9
Epididymis fat weight0.30.70.90.80.8-0.80.80.80.9-0.91.0
Delta time in closed arm before/after self-admin7.16.97.62.12.7-2.72.72.72.7-2.52.8
Delta time in open arm before/after self-admin8.07.79.3-3.0-2.72.7-2.8-2.8-2.82.6-2.8
Diff in mean of infusions in LGA sessions0.40.40.80.40.9-0.90.50.50.8-0.40.5
Delay discount exponential model param3.03.14.32.01.7-1.71.61.61.7-2.11.7
Extinction: sum of active levers before priming0.60.60.6-0.8-0.80.8-0.8-0.8-0.60.8-0.8
Active lever presses in extinction session 60.10.10.2-0.4-0.10.1-0.3-0.3-0.00.3-0.1
Bone: final force0.40.61.0-0.8-0.70.7-0.9-0.9-0.60.8-1.0
Bone: final moment0.60.91.3-0.9-0.90.9-1.0-1.0-0.70.9-1.1
Food consumed during 24 hour testing period2.22.72.9-1.6-1.71.7-1.7-1.7-1.71.4-1.7
Glucose19.629.534.4-5.7-5.75.7-5.6-5.6-5.94.1-5.0
Heart weight0.20.30.60.70.6-0.60.10.10.4-0.80.3
Delay discount hyperbolic model param3.13.24.62.01.7-1.71.71.71.8-2.11.7
Intermittent access intake day 1-15 change0.50.50.6-0.4-0.80.8-0.8-0.8-0.70.4-0.7
Intermittent access intake escalation0.30.30.4-0.3-0.60.6-0.6-0.6-0.50.2-0.5
Intermittent access intake escalation 20.20.20.3-0.4-0.50.5-0.5-0.5-0.4-0.0-0.4
Intermitt. access day 1 inactive lever presses0.60.60.80.60.8-0.80.90.90.8-0.50.8
Intermitt. access day 15 inactive lever presses1.31.41.6-1.1-1.31.3-1.1-1.1-1.11.1-1.3
Intermitt. access escalation Index0.20.20.3-0.1-0.50.5-0.5-0.5-0.40.2-0.6
Intermittent access day 1 total infusions0.30.30.40.40.6-0.60.70.70.6-0.40.6
Intermittent access day 15 total infusions0.10.10.2-0.3-0.40.4-0.4-0.4-0.30.2-0.3
Intermittent access terminal intake (last 3 days)0.10.10.1-0.1-0.30.3-0.3-0.3-0.2-0.0-0.2
Intermittent access total infusions0.00.00.0-0.1-0.10.1-0.0-0.0-0.00.0-0.1
Intermittent access day 1 locomotion1.11.21.31.11.1-1.11.11.11.1-0.81.1
Intermittent access day 15 total locomotion0.20.20.3-0.3-0.40.4-0.4-0.4-0.40.6-0.3
Intermittent access total locomotion0.10.20.4-0.3-0.40.4-0.4-0.4-0.30.6-0.4
Intermittent access standard deviation1.21.22.21.11.0-1.01.11.11.1-1.51.0
Left kidney weight0.10.20.5-0.10.7-0.70.50.50.40.00.4
Right kidney weight1.02.83.81.11.9-1.91.71.71.9-1.31.6
Cocaine induced anxiety3.54.04.9-1.7-2.02.0-2.2-2.2-1.91.9-2.0
Post-drug Anxiety1.21.31.7-1.0-1.11.1-1.3-1.3-1.21.0-1.1
Baseline Anxiety0.30.30.50.40.6-0.60.70.70.3-0.50.6
Tail length1.13.44.3-2.0-1.61.6-1.9-1.9-1.52.1-2.0
Length with tail1.96.89.6-3.1-2.32.3-2.6-2.6-2.42.9-2.5
Length without tail1.32.84.4-2.1-1.51.5-1.6-1.6-1.71.7-1.3
Times rat made contact with spout0.20.30.4-0.4-0.50.5-0.6-0.6-0.6-0.6-0.2
Lifetime Intake0.00.00.0-0.1-0.10.1-0.0-0.0-0.00.1-0.1
Liver weight, left2.54.05.01.52.2-2.22.12.12.1-1.72.0
Liver weight, right4.37.19.12.22.8-2.82.82.82.7-2.13.0
Locomotor activity0.40.71.7-1.3-0.80.8-0.6-0.6-0.90.5-1.0
Locomotor testing distance0.10.10.2-0.5-0.10.1-0.1-0.1-0.30.5-0.5
Locomotor testing rearing1.82.83.1-1.7-1.71.7-1.6-1.6-1.81.5-1.7
Locomotion in novel chamber4.75.87.02.52.3-2.32.22.22.4-2.62.7
Locomotion in novel chamber post-restriction2.73.34.01.71.7-1.71.81.81.8-1.92.0
Fecal boli incidents, locomotor time 10.30.30.50.70.5-0.50.70.70.5-0.40.4
Change in fecal boli incidents, locomotor task0.10.10.2-0.4-0.20.2-0.3-0.3-0.40.0-0.3
Time >=10cm from walls, locomotor time 10.10.10.50.00.1-0.10.40.4-0.1-0.50.7
Bouts of movement, locomotor time 10.50.60.8-0.7-0.90.9-0.7-0.7-0.80.4-0.7
Total resting periods, locomotor time 10.20.20.3-0.4-0.50.5-0.4-0.4-0.60.1-0.4
Rest time, locomotor task time 10.10.10.2-0.1-0.50.5-0.1-0.1-0.4-0.10.1
Distance moved, locomotor task time 10.20.20.5-0.5-0.20.2-0.4-0.4-0.30.7-0.6
Vertical activity count, locomotor time 10.10.10.2-0.50.0-0.0-0.4-0.4-0.00.3-0.2
Time >=10cm from walls, locomotor time 20.60.61.20.00.8-0.81.01.00.4-0.61.1
Bouts of movement, locomotor time 20.20.20.70.30.2-0.20.30.30.20.9-0.6
Total resting periods, locomotor time 20.20.20.80.20.0-0.00.30.30.00.9-0.7
Rest time, locomotor task time 20.10.10.20.40.0-0.00.40.4-0.0-0.3-0.0
Distance moved, locomotor task time 20.10.10.20.10.2-0.20.20.20.3-0.30.4
Vertical activity count, locomotor time 20.10.10.70.10.1-0.10.10.10.3-0.50.9
Light reinforcement 10.10.20.3-0.2-0.60.6-0.4-0.4-0.30.6-0.4
Light reinforcement 20.00.00.3-0.30.0-0.00.00.0-0.10.50.1
Bone: marrow area0.00.00.2-0.5-0.10.1-0.1-0.1-0.00.2-0.2
Bone: maximum diameter5.29.510.5-3.1-3.23.2-3.0-3.0-3.22.9-2.9
Bone: maximum force0.30.50.6-0.7-0.70.7-0.8-0.8-0.60.7-0.8
Bone: maximum moment0.50.80.9-0.9-0.90.9-0.9-0.9-0.70.9-0.9
Mean time between licks in bursts0.50.71.0-1.0-0.60.6-0.9-0.9-1.00.5-0.7
Mean num. licks in bursts1.82.23.91.51.5-1.51.21.21.3-2.01.4
Cd content in liver0.30.40.50.60.7-0.70.70.70.5-0.40.4
Co content in liver0.10.10.40.2-0.00.0-0.1-0.1-0.10.2-0.6
Cu content in liver0.50.60.8-0.8-0.80.8-0.9-0.9-0.90.7-0.8
Fe content in liver0.10.20.30.50.4-0.40.20.20.4-0.60.5
K content in liver0.50.51.0-0.5-0.70.7-0.6-0.6-0.81.0-0.3
Mg content in liver0.50.50.8-0.3-0.80.8-0.7-0.7-0.90.7-0.6
Mn content in liver0.10.10.40.1-0.30.3-0.3-0.3-0.30.7-0.2
Na content in liver4.44.75.2-2.2-2.32.3-2.2-2.2-2.22.0-2.0
Rb content in liver2.83.54.1-1.8-2.02.0-1.7-1.7-2.01.9-1.8
Se content in liver1.72.12.6-1.2-1.51.5-1.4-1.4-1.41.6-1.4
Sr content in liver1.91.72.2-1.5-1.11.1-1.4-1.4-1.41.3-1.4
Zn content in liver0.30.40.7-0.5-0.50.5-0.5-0.5-0.80.8-0.5
Bone: minimum diameter0.00.00.00.00.1-0.1-0.0-0.00.10.10.2
Time in familiar zone, hab. session 10.10.10.20.50.4-0.40.00.00.4-0.20.1
Time in novel zone, hab. session 10.30.20.5-0.7-0.60.6-0.3-0.3-0.60.3-0.3
Total zone transitions, hab. session 10.10.10.1-0.1-0.40.4-0.3-0.3-0.30.10.0
Total locomotion distance, hab. session 10.10.20.3-0.3-0.50.5-0.4-0.4-0.50.6-0.1
Locomotion velocity, hab. session 10.00.00.1-0.0-0.20.2-0.2-0.2-0.30.20.1
Time in familiar zone, hab. session 22.02.12.81.21.7-1.71.41.41.7-1.31.2
Time in novel zone, hab. session 23.03.03.9-1.5-2.02.0-1.7-1.7-2.01.5-1.5
Total zone transitions, hab. session 21.01.31.6-0.9-1.21.2-1.2-1.2-1.21.3-0.9
Total locomotion distance, hab. session 21.31.72.1-0.9-1.41.4-1.4-1.4-1.41.5-1.1
Locomotion velocity, hab. session 21.52.02.8-1.1-1.41.4-1.4-1.4-1.51.7-1.2
Novel to familiar place preference ratio0.80.81.3-1.1-1.01.0-0.9-0.9-1.00.4-0.4
Novelty place preference0.90.91.4-1.2-1.11.1-0.9-0.9-1.10.4-0.4
Time in novel zone, NPP test0.90.91.3-1.2-1.11.1-0.9-0.9-1.10.4-0.4
Total zone transitions, NPP test0.30.40.90.90.6-0.60.60.60.5-0.20.6
Total locomotion distance, NPP test0.00.10.20.40.2-0.20.10.10.10.30.3
Locomotion velocity, NPP test0.00.00.20.20.0-0.0-0.1-0.1-0.10.50.1
Intraocular pressure0.40.60.8-0.9-0.80.8-0.6-0.6-0.90.7-0.7
Delta distance traveled before/after self-admin0.30.30.40.50.6-0.60.60.60.5-0.10.5
Delta ambulatory time before/after self-admin0.40.50.60.70.8-0.80.80.80.7-0.40.6
Parametrial fat weight2.03.85.4-2.3-1.91.9-1.9-1.9-1.91.9-1.8
Pavlov. Cond. lever latency0.50.61.2-1.1-0.80.8-0.7-0.7-0.80.4-0.7
Pavlov. Cond. magazine entry latency1.92.44.12.01.5-1.51.51.51.6-1.41.4
Pavlov. Cond. change in total contacts1.31.42.0-0.7-1.21.2-1.3-1.3-1.11.3-1.4
Pavlov. Cond. index score2.02.54.52.11.6-1.61.51.51.6-1.31.4
Pavlov. Cond. latency score1.72.13.61.91.4-1.41.41.41.5-1.11.3
Pavlov. Cond. lever contacts0.70.82.01.40.9-0.90.80.80.9-0.50.7
Pavlov. Cond. magazine entry number1.82.34.5-2.1-1.41.4-1.4-1.4-1.61.4-1.2
Pavlov. Cond. intertrial magazine entries0.20.30.9-0.8-0.30.3-0.4-0.4-0.41.0-0.3
Pavlov. Cond. lever-magazine prob. diff.2.32.95.12.31.7-1.71.61.61.8-1.41.5
Pavlov. Cond. response bias0.81.02.91.70.9-0.90.80.81.0-0.70.6
Pavlov. Cond. lever latency3.34.56.1-2.2-2.12.1-2.0-2.0-2.12.5-1.9
Pavlov. Cond. magazine entry latency0.00.00.10.3-0.10.10.00.0-0.2-0.10.1
Pavlov. Cond. change in total contacts0.20.30.40.50.7-0.70.60.60.5-0.70.6
Pavlov. Cond. index score1.21.52.01.41.2-1.21.21.21.1-1.41.2
Pavlov. Cond. latency score1.31.62.11.41.2-1.21.21.21.2-1.41.2
Pavlov. Cond. lever contacts3.04.05.31.92.0-2.02.02.02.0-2.31.9
Pavlov. Cond. magazine entry number0.00.00.1-0.20.1-0.10.10.10.20.40.0
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.0-0.10.1-0.2-0.20.10.2-0.2
Pavlov. Cond. lever-magazine prob. diff.1.21.52.01.41.2-1.21.21.21.1-1.41.2
Pavlov. Cond. response bias1.21.62.61.21.2-1.21.21.21.2-1.61.2
Time in closed arm before self-admin0.40.40.5-0.6-0.70.7-0.6-0.6-0.70.5-0.7
Time in closed arm after self-admin2.22.32.61.51.4-1.41.61.61.5-1.41.5
Time in open arm before self-admin2.42.63.01.71.6-1.61.51.51.7-1.61.7
Time in open arm after self-admin0.20.20.3-0.5-0.30.3-0.5-0.5-0.40.3-0.4
Bone: periosteal estimation0.91.92.5-1.6-1.41.4-1.4-1.4-1.31.4-1.2
Bone: periosteal perimeter1.83.03.7-1.9-1.71.7-1.8-1.8-1.71.9-1.4
Bone: post-yield work0.30.40.6-0.6-0.80.8-0.6-0.6-0.70.5-0.4
Progressive ratio test 1 active lever presses0.00.00.00.00.1-0.10.10.10.10.00.0
Progressive ratio test 1 breakpoint0.20.20.20.40.4-0.40.50.50.5-0.40.4
Progressive ratio test 1 inactive lever presses2.32.53.9-1.7-1.51.5-1.4-1.4-1.52.0-1.5
Progressive ratio test 2 active lever presses0.00.00.0-0.2-0.10.1-0.1-0.10.0-0.10.0
Progressive ratio test 2 breakpoint0.00.00.0-0.1-0.10.1-0.1-0.1-0.1-0.0-0.1
Progressive ratio test 2 inactive lever presses0.50.60.8-0.7-0.80.8-0.8-0.8-0.70.9-0.7
Incentive Sensitization - Responses0.00.00.0-0.2-0.10.1-0.2-0.2-0.2-0.10.0
Incentive Sensitization - Breakpoint0.00.00.0-0.1-0.00.0-0.1-0.1-0.1-0.20.1
Sum of active levers in priming session hrs 5-61.21.21.6-1.0-1.01.0-1.2-1.2-0.91.2-1.1
Progressive ratio0.20.20.40.40.7-0.70.30.30.6-0.40.5
Food seeking constrained by brief footshock1.82.23.4-1.5-1.51.5-1.6-1.6-1.31.8-1.2
Seeking ratio, punishment vs. effort1.41.72.2-1.2-1.51.5-1.1-1.1-1.31.5-1.1
Retroperitoneal fat weight0.00.00.1-0.20.2-0.20.10.10.30.3-0.0
Reaction time number correct0.10.10.3-0.1-0.50.5-0.2-0.2-0.50.1-0.3
Reaction time mean minus median1.72.23.31.11.6-1.61.61.61.2-1.81.4
Reaction time mean minus median AUC1.41.92.71.01.5-1.51.41.41.1-1.61.3
Reaction time num false alarms0.40.51.00.1-0.50.5-0.9-0.9-0.41.0-0.9
Reaction time num false alarms AUC0.30.40.90.3-0.30.3-0.7-0.7-0.21.0-0.8
Reaction time trials correct on left0.10.10.3-0.1-0.50.5-0.2-0.2-0.50.1-0.3
Reaction time trials on left0.10.10.2-0.0-0.50.5-0.2-0.2-0.40.1-0.3
Reaction time mean1.01.41.80.71.4-1.41.31.31.1-1.10.9
Reaction time mean AUC1.62.12.61.01.6-1.61.61.61.4-1.41.3
Median of all reaction times0.50.71.10.41.0-1.01.01.00.9-0.70.6
Reaction time omissions1.52.12.71.41.6-1.61.61.61.4-1.21.0
Reaction time false alarm rate0.20.20.70.2-0.10.1-0.6-0.60.00.9-0.6
Reaction time premature initiation rate2.93.94.41.92.1-2.12.02.01.9-1.82.0
Reaction time premature initiations1.41.92.21.51.4-1.41.51.51.2-1.31.4
Std. dev. reaction times1.62.22.91.01.7-1.71.51.51.4-1.61.2
Reaction time trials completed0.10.10.2-0.0-0.50.5-0.2-0.2-0.40.1-0.3
Reaction time trials AUC0.10.20.3-0.1-0.60.6-0.3-0.3-0.50.2-0.4
Run reversals in cocaine runway, females0.50.50.90.90.8-0.80.50.50.9-0.50.6
Run reversals in cocaine runway, males0.40.40.6-0.8-0.70.7-0.6-0.6-0.70.5-0.5
Latency to leave start box in cocaine runway0.10.10.2-0.10.2-0.2-0.3-0.30.20.5-0.4
Latency to leave start box in cocaine runway, F0.50.50.8-0.8-0.40.4-0.8-0.8-0.60.9-0.7
Latency to leave start box in cocaine runway, M0.80.81.40.91.0-1.00.80.81.2-0.70.5
Std. dev. time between licks in bursts0.00.00.00.1-0.00.0-0.2-0.2-0.10.0-0.2
Total sessions with >9 infusions0.10.10.30.50.1-0.10.10.10.2-0.20.2
Short access day 1 total inactive lever presses3.03.34.3-1.8-1.81.8-1.8-1.8-1.62.1-1.8
Short access day 10 total inactive lever presses0.10.10.20.30.3-0.30.30.30.4-0.20.3
Short access day 1 total infusions0.40.50.60.60.8-0.80.80.80.7-0.50.7
Short access day 10 total infusions0.50.50.70.70.7-0.70.80.80.8-0.60.7
Short access total infusions0.50.60.70.80.8-0.80.80.80.8-0.70.7
Short access day 1 locomotion1.92.02.61.61.4-1.41.41.41.4-1.11.4
Short access day 10 total locomotion0.80.91.00.91.0-1.01.01.01.0-0.60.9
Short access total locomotion4.04.24.42.12.1-2.12.12.12.1-1.82.0
One hour access (0.3 mA shock)0.00.00.10.10.1-0.10.10.10.3-0.20.2
Compulsive drug intake2.22.32.81.71.4-1.41.41.41.7-1.51.5
One hour access (shock baseline)0.50.61.0-1.0-0.80.8-0.7-0.7-0.70.7-0.7
Social response proportion2.12.32.9-1.6-1.61.6-1.5-1.5-1.71.5-1.2
Social responses2.63.43.7-1.7-1.91.9-1.7-1.7-1.91.8-1.9
Social time0.30.40.6-0.5-0.70.7-0.6-0.6-0.50.7-0.8
Soleus weight0.51.52.7-1.6-1.01.0-1.1-1.1-1.11.6-1.0
Bone: stiffness0.00.00.0-0.10.0-0.00.00.0-0.0-0.10.2
Tibialis anterior weight1.24.14.6-2.1-2.12.1-2.0-2.0-1.81.9-2.1
Time to tail flick, vehicle, before self-admin0.00.00.10.30.3-0.30.10.10.20.20.1
Time to tail flick, vehicle, after self-admin0.10.10.20.40.2-0.20.00.00.00.4-0.4
Time to tail flick, test, before self-admin0.80.81.40.80.9-0.90.80.80.7-1.20.8
Time to tail flick, test, after self-admin3.13.24.4-1.4-1.81.8-1.8-1.8-1.82.1-1.7
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.00.1-0.10.20.20.0-0.00.0
Delta time to tail flick, test, before/after SA2.82.53.5-1.2-1.61.6-1.7-1.7-1.51.9-1.5
Tibia length0.10.30.70.30.8-0.80.50.50.9-0.10.6
Ambulatory time before self-admin0.50.50.7-0.9-0.60.6-0.8-0.8-0.60.6-0.7
Ambulatory time after self-admin0.20.20.4-0.6-0.20.2-0.6-0.6-0.30.7-0.5
Bone: tissue strength0.00.00.2-0.4-0.00.0-0.0-0.0-0.2-0.3-0.1
Total heroin consumption0.10.10.2-0.1-0.30.3-0.3-0.3-0.20.1-0.4
Bone: trabecular number0.00.10.10.30.2-0.20.20.20.3-0.20.1
Bone: trabecular spacing1.01.31.6-1.3-1.11.1-1.2-1.2-1.21.1-1.0
Bone: trabecular thickness1.21.41.91.41.2-1.21.31.31.3-0.81.1
Bone: trabecular tissue density0.20.20.60.30.3-0.30.50.50.3-0.80.6
Water consumed over 24 hours1.72.02.4-1.4-1.51.5-1.6-1.6-1.61.0-1.3
Number of responses in last shaping day0.00.00.10.20.1-0.1-0.0-0.00.40.10.1