Hub : Genes

Adig

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Adig	0.27	0.11	0.0e+00	0.12	0.19	0.2	0.19	3.8e-13	3.9e-21	3.0e-21	6.4e-21
2	Liver	gene expression	Adig	0.37	0.19	6.3e-10	0.03	0.07	0.07	0.07	1.6e-04	6.7e-08	1.2e-08	2.9e-08
3	NAcc	gene expression	Adig	0.03	0.02	4.6e-03	0.01	0.01	0.01	0.01	9.4e-03	1.2e-02	7.4e-03	2.5e-03
4	Adipose	mRNA stability	Adig	0.17	0.08	2.2e-13	0.11	0.08	0.09	0.1	4.3e-12	2.1e-09	2.7e-10	7.9e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	5.0	9.2	12.3	-2.6	-3.1	3.5	2.9
Area under the delay curve	0.6	0.9	1.5	1.2	-1.2	-0.1	-0.9
BMI with tail	0.2	0.8	1.7	1.3	-1.1	-0.0	-0.4
BMI without tail	0.1	0.5	1.3	0.4	-1.1	0.5	-0.5
Body weight	0.2	0.7	1.6	1.3	-0.7	-0.2	-0.8
Weight adjusted by age	0.1	0.4	1.2	-1.1	-0.1	0.2	-0.7
Bone surface	3.1	6.2	8.7	-2.2	-3.0	2.9	1.6
Bone volume	4.0	8.0	11.2	-2.6	-3.2	3.3	1.9
Breakpoint value in progressive ratio session	0.9	1.6	3.8	1.5	-0.4	-0.7	-1.9
Number of licking bursts	0.1	0.2	0.3	-0.5	0.3	0.5	-0.5
Context. condit. distance diff. score	0.3	0.4	0.8	0.9	0.3	-0.4	-0.8
Locomotion velocity, session 1	0.4	0.4	0.7	0.8	0.7	-0.8	-0.2
Locomotion distance, session 1	2.1	2.7	4.5	1.3	2.0	-2.1	-0.6
Locomotion velocity, session 2	0.3	0.4	0.7	0.0	-0.8	0.8	0.4
Locomotion distance, session 2	0.4	0.6	1.0	0.8	1.0	-0.9	-0.2
Locomotion velocity, session 3	0.8	0.9	1.3	-0.4	-1.0	1.1	0.9
Locomotion distance, session 3	0.4	0.5	0.7	0.7	0.7	-0.8	-0.4
Stereotopy head waving bouts, day 3	1.6	1.9	3.4	-1.2	-0.5	1.6	1.8
Stereotopy head waving duration, day 3	1.2	1.5	2.7	-0.9	-0.8	1.6	1.3
Locomotion velocity, session 7	0.3	0.3	1.2	1.1	0.1	-0.3	-0.2
Locomotion distance, session 7	1.0	1.2	1.9	1.4	1.0	-1.2	-0.7
Stereotopy head waving bouts, day 7	0.6	0.7	1.4	-1.1	0.1	0.3	1.2
Stereotopy head waving duration, day 7	0.5	0.7	1.2	-1.1	-0.4	0.7	0.9
Locomotion velocity, session 8	0.4	0.4	0.6	-0.7	-0.8	0.7	-0.1
Locomotion distance, session 8	0.1	0.1	0.3	0.4	0.1	-0.0	-0.5
Degree of sensitization distance	0.5	0.5	1.1	0.4	1.0	-0.8	0.6
Degree of sensitization stereotypy	0.4	0.5	1.3	-1.2	-0.3	0.2	0.7
Conditioned locomotion	0.4	0.4	1.2	0.3	-0.2	0.6	1.1
Cocaine response after cond. corrected	0.7	1.0	2.5	-1.1	0.7	0.3	1.6
Cocaine response after cond. not corrected	0.9	1.2	3.2	-0.9	1.0	0.1	1.8
Cocaine response before conditioning	0.5	0.6	1.0	1.0	0.6	-0.9	-0.0
Saline control response	0.7	0.9	2.3	-0.1	1.0	-0.5	1.5
Bone: connectivity density	4.1	6.5	8.1	-2.2	-2.4	2.7	2.8
Bone: cortical apparent density	0.0	0.0	0.1	-0.3	-0.2	0.0	0.1
Bone: cortical area	1.7	2.8	7.1	-0.8	-2.7	1.8	0.1
Bone: cortical porosity	0.4	0.5	1.2	0.1	-0.5	0.7	1.1
Bone: cortical porosity	0.3	0.4	1.2	0.2	-0.2	0.4	1.1
Bone: cortical thickness	1.7	2.8	6.3	-1.2	-2.5	1.7	0.6
Bone: cortical thickness	1.4	1.7	2.7	-1.7	-1.3	1.4	0.5
Bone: cortical tissue density	0.0	0.0	0.0	-0.1	0.0	-0.2	-0.0
Condit. Reinf. active minus inactive responses	0.7	0.8	1.8	1.3	0.3	-0.8	0.7
Condit. Reinf. active-inactive response ratio	0.8	0.8	2.6	0.3	-0.6	0.4	1.6
Condit. Reinf. active responses	1.0	1.3	3.3	1.8	0.8	-1.0	-0.2
Condit. Reinf. inactive responses	1.1	1.4	1.7	1.1	1.3	-1.1	-1.1
Incentive salience index mean	0.3	0.4	0.7	0.7	-0.8	0.4	0.4
Condit. Reinf. lever presses	0.2	0.4	0.6	0.4	-0.7	0.5	-0.8
Condit. Reinf. active minus inactive responses	0.3	0.4	1.2	0.6	0.1	-0.3	1.1
Condit. Reinf. active-inactive response ratio	0.2	0.4	1.2	1.1	-0.1	-0.3	0.5
Condit. Reinf. active responses	0.3	0.5	1.6	0.3	0.3	-0.3	1.3
Condit. Reinf. inactive responses	0.2	0.3	0.7	-0.8	0.0	0.3	0.6
Condit. Reinf. lever presses	0.5	0.8	2.8	-0.4	-0.2	0.2	1.7
Condit. Reinf. lever reinforcers received	0.5	0.6	2.1	0.2	0.6	-0.4	1.4
Conditioned reinforcement - actives	0.4	1.7	6.7	-2.6	0.4	0.1	-0.1
Conditioned reinforcement - inactives	3.7	10.0	27.3	-5.2	-0.7	2.6	2.3
Conditioned locomotion	1.3	1.9	4.5	-2.1	-0.1	0.8	1.6
Patch foraging indifference point 0 sec	0.1	0.3	0.7	-0.8	-0.8	0.0	0.2
Patch foraging indifference point AUC	0.2	0.4	1.0	-1.0	-0.6	0.6	0.1
Delay disc. indifference point, 0s delay	1.5	1.7	3.3	-0.5	-1.6	1.8	0.6
Delay disc. indifference point, 16s delay	0.5	0.6	1.9	1.4	-0.7	-0.4	0.3
Delay disc. indifference point, 2s delay	0.5	0.6	1.8	0.1	-1.4	0.6	0.2
Delay disc. indifference point, 24s delay	1.1	1.8	4.4	1.3	-0.7	-0.9	-2.1
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	0.5	-0.7	-0.3	-1.1
Delay disc. indifference point, 8s delay	0.7	1.2	3.1	1.2	-1.7	0.2	-0.5
Indifference point function ln k	0.3	0.9	2.6	0.8	-0.6	-0.0	-1.6
Indifference point function log k	0.3	0.9	2.6	0.8	-0.6	-0.0	-1.6
Patch foraging total patch changes 0 sec	0.1	0.3	0.9	-0.7	-0.9	0.0	0.0
Patch foraging total patch changes 12 sec	1.2	1.6	3.1	-1.8	-1.4	1.0	0.5
Patch foraging total patch changes 18 sec	0.2	0.4	0.8	-0.9	-0.2	0.3	0.9
Patch foraging total patch changes 24 sec	0.1	0.2	0.5	0.4	0.5	-0.7	-0.0
Patch foraging total patch changes 6 sec	0.9	1.6	2.4	-1.3	-1.5	1.2	0.9
Patch foraging time to switch 0 sec	0.0	0.2	0.2	-0.5	-0.3	0.5	0.3
Patch foraging water rate 0 sec	0.2	0.7	1.6	0.1	-1.3	0.8	-0.7
Patch foraging water rate 12 sec	0.2	1.0	2.3	1.5	0.6	-0.5	1.0
Patch foraging water rate 18 sec	0.8	1.9	3.2	0.7	-1.5	1.2	-1.8
Patch foraging water rate 24 sec	0.5	0.7	2.2	0.2	-0.6	0.5	-1.5
Patch foraging water rate 6 sec	0.5	0.8	1.7	0.1	-1.3	1.1	0.4
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	1.6	1.3	-0.1	-0.2	-0.9
Distance traveled before self-admin	0.1	0.1	0.4	0.3	-0.6	-0.1	0.2
Distance traveled after self-admin	0.3	0.5	1.4	1.2	-0.3	-0.5	0.4
Extensor digitorum longus weight	0.1	0.3	0.6	0.8	-0.6	-0.3	-0.4
Bone: elastic displacement	0.4	0.5	1.0	-0.2	0.9	-1.0	-0.2
Bone: elastic work	0.3	0.4	0.8	-0.6	-0.9	0.3	-0.5
Bone: endosteal estimation	0.2	0.4	0.8	-0.1	-0.9	0.9	-0.2
Bone: endosteal perimeter	0.1	0.3	0.7	0.7	-0.3	0.1	-0.9
Epididymis fat weight	0.0	0.1	0.2	-0.4	0.1	0.2	-0.3
Delta time in closed arm before/after self-admin	2.6	2.5	4.3	-2.1	-1.5	1.5	1.1
Delta time in open arm before/after self-admin	0.5	0.6	1.5	1.2	0.4	-0.4	0.7
Diff in mean of infusions in LGA sessions	0.8	1.5	2.4	0.7	1.5	-1.1	-1.3
Delay discount exponential model param	0.9	1.2	1.7	-1.3	1.1	0.4	1.3
Extinction: sum of active levers before priming	0.4	0.6	1.9	0.1	1.4	0.2	0.8
Active lever presses in extinction session 6	0.4	0.4	0.7	0.6	0.6	-0.9	-0.3
Bone: final force	1.2	1.9	5.0	-0.3	-2.2	1.6	-0.3
Bone: final moment	0.8	1.3	3.7	-0.1	-1.9	1.2	-0.1
Food consumed during 24 hour testing period	0.2	0.5	1.4	0.3	0.4	-0.5	1.2
Glucose	0.8	1.2	1.8	-1.3	-1.3	1.2	0.1
Heart weight	0.6	0.9	2.3	-0.5	1.5	-0.1	1.1
Delay discount hyperbolic model param	0.8	1.1	1.5	-1.2	1.1	0.4	1.2
Intermittent access intake day 1-15 change	0.3	1.5	2.6	-1.6	-0.6	1.6	0.6
Intermittent access intake escalation	0.3	1.5	2.6	-1.6	-0.7	1.6	0.8
Intermittent access intake escalation 2	0.6	1.1	2.3	-1.1	-0.6	1.5	0.6
Intermitt. access day 1 inactive lever presses	0.3	3.6	8.0	-2.8	-1.3	1.7	1.4
Intermitt. access day 15 inactive lever presses	0.7	3.6	6.9	-2.6	-0.3	1.9	2.0
Intermitt. access escalation Index	0.5	1.7	2.9	1.7	0.6	-1.1	-1.5
Intermittent access day 1 total infusions	0.2	0.6	1.6	-1.3	0.5	0.4	0.5
Intermittent access day 15 total infusions	0.3	0.7	1.6	-1.3	0.0	1.0	0.5
Intermittent access terminal intake (last 3 days)	0.6	1.1	2.2	-1.5	0.3	1.1	1.0
Intermittent access total infusions	0.6	0.7	1.5	-1.2	0.8	0.7	0.6
Intermittent access day 1 locomotion	0.2	0.4	0.7	0.9	0.8	-0.6	-0.0
Intermittent access day 15 total locomotion	0.1	0.4	1.4	-1.2	-0.2	0.0	0.5
Intermittent access total locomotion	0.0	0.1	0.2	-0.4	0.1	-0.1	0.1
Intermittent access standard deviation	0.5	2.4	4.1	-2.0	-1.1	1.9	1.0
Left kidney weight	0.2	1.2	2.8	1.2	0.5	-0.5	1.7
Right kidney weight	0.2	1.7	5.0	0.3	-1.0	0.9	2.2
Cocaine induced anxiety	0.2	0.6	2.3	1.5	0.3	-0.2	0.2
Post-drug Anxiety	1.2	1.4	4.5	2.1	-0.4	-0.3	-0.8
Baseline Anxiety	0.5	0.9	1.7	1.3	-0.0	-0.6	-1.2
Tail length	0.0	0.2	0.6	-0.1	-0.4	0.3	-0.8
Length with tail	0.1	0.5	1.1	0.7	0.4	-0.7	-1.0
Length without tail	0.3	1.4	2.4	1.3	1.3	-1.6	-0.4
Times rat made contact with spout	0.3	0.4	1.4	0.3	-0.1	0.0	-1.2
Lifetime Intake	2.0	2.4	5.5	-2.4	0.2	1.6	1.3
Liver weight, left	0.3	0.4	0.8	-0.3	-0.5	0.9	0.8
Liver weight, right	0.5	0.9	2.6	-0.1	-1.6	0.8	-0.7
Locomotor activity	0.7	1.1	1.5	-0.7	-1.2	1.1	1.1
Locomotor testing distance	0.4	0.9	1.4	-0.9	-1.2	0.8	0.8
Locomotor testing rearing	0.1	0.2	0.4	0.2	-0.7	-0.3	-0.4
Locomotion in novel chamber	1.1	1.4	1.8	-1.2	-1.2	1.3	-1.0
Locomotion in novel chamber post-restriction	0.1	0.4	1.1	-0.1	-1.0	0.5	0.6
Fecal boli incidents, locomotor time 1	1.0	2.7	3.1	-1.4	-1.8	1.5	1.8
Change in fecal boli incidents, locomotor task	2.5	2.6	4.3	2.1	1.3	-1.7	-1.3
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.8	0.9	-0.0	0.2	0.5
Bouts of movement, locomotor time 1	0.8	1.0	3.0	-1.7	-0.7	0.5	0.3
Total resting periods, locomotor time 1	0.5	0.6	1.9	-1.4	-0.6	0.2	0.2
Rest time, locomotor task time 1	1.5	2.4	3.7	-1.6	-0.6	1.6	1.9
Distance moved, locomotor task time 1	0.3	0.8	1.6	1.2	-0.7	-0.5	-1.0
Vertical activity count, locomotor time 1	0.1	0.7	1.2	0.9	0.5	-1.1	-0.7
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.9	1.4	0.4	-0.4	-0.4
Bouts of movement, locomotor time 2	0.3	1.1	2.3	1.5	-0.2	-0.8	-1.1
Total resting periods, locomotor time 2	0.2	0.8	1.9	1.4	-0.3	-0.6	-0.8
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.4	0.2	0.6	0.4
Distance moved, locomotor task time 2	0.2	0.3	0.8	0.5	-0.9	0.0	-0.2
Vertical activity count, locomotor time 2	0.2	0.4	1.2	1.1	-0.1	-0.4	-0.2
Light reinforcement 1	0.2	0.9	1.3	-1.1	-1.0	1.1	0.4
Light reinforcement 2	0.2	0.4	0.9	-0.7	0.2	0.1	-1.0
Bone: marrow area	0.2	0.6	1.1	-0.2	-1.1	1.0	-0.2
Bone: maximum diameter	0.8	1.7	3.7	-0.1	-1.9	1.2	-1.2
Bone: maximum force	2.0	3.9	9.9	-0.5	-3.2	2.3	0.2
Bone: maximum moment	1.6	3.0	7.9	-0.3	-2.8	2.0	0.4
Mean time between licks in bursts	0.3	2.0	3.1	1.6	1.8	-1.4	-0.6
Mean num. licks in bursts	0.1	0.2	0.4	0.6	-0.2	-0.5	0.1
Cd content in liver	0.6	0.7	1.1	1.1	0.7	-0.6	0.8
Co content in liver	1.4	1.6	2.7	-1.0	-1.6	1.5	0.7
Cu content in liver	1.8	2.2	3.0	-1.5	-1.3	1.4	1.7
Fe content in liver	1.5	1.9	2.2	1.5	1.2	-1.4	1.4
K content in liver	4.1	4.0	5.6	-2.1	-2.4	2.4	0.6
Mg content in liver	5.0	5.5	6.5	-2.6	-2.4	2.5	1.9
Mn content in liver	0.4	0.4	1.0	-1.0	0.6	-0.4	0.5
Na content in liver	0.7	0.8	1.8	-0.5	-1.1	1.3	-0.1
Rb content in liver	0.8	1.0	1.6	-1.3	-1.0	1.0	0.6
Se content in liver	2.7	3.2	5.6	1.7	2.4	-2.1	0.1
Sr content in liver	0.4	0.3	1.0	1.0	-0.0	-0.2	-0.6
Zn content in liver	3.5	4.0	5.9	-1.5	-2.0	2.4	2.0
Bone: minimum diameter	0.4	0.8	1.9	0.3	-1.4	0.9	-0.6
Time in familiar zone, hab. session 1	0.4	0.5	1.0	-0.1	-0.8	1.0	-0.4
Time in novel zone, hab. session 1	1.5	1.7	3.0	1.4	1.3	-1.7	0.1
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.5	0.5	-0.4	-0.0
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.3	0.2	-0.1	-0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.5	-0.1	0.1	0.1	-0.7
Time in familiar zone, hab. session 2	0.3	0.3	0.9	0.5	0.3	-0.1	-0.9
Time in novel zone, hab. session 2	0.3	0.3	0.8	0.7	0.3	-0.9	0.2
Total zone transitions, hab. session 2	0.7	0.9	1.9	-1.4	-0.8	0.7	0.7
Total locomotion distance, hab. session 2	0.9	1.2	1.9	-1.4	-1.2	1.1	0.6
Locomotion velocity, hab. session 2	1.2	1.6	2.5	-1.6	-1.3	1.3	0.6
Novel to familiar place preference ratio	1.5	1.9	4.8	-0.6	-2.2	1.6	-0.3
Novelty place preference	1.7	2.2	5.7	-0.4	-2.4	1.6	-0.7
Time in novel zone, NPP test	1.3	1.6	4.4	-0.2	-2.1	1.3	-0.6
Total zone transitions, NPP test	0.2	0.3	0.5	-0.7	-0.2	0.2	0.7
Total locomotion distance, NPP test	0.0	0.0	0.0	0.2	0.0	0.0	-0.0
Locomotion velocity, NPP test	0.2	0.2	0.5	-0.2	-0.7	0.7	0.1
Intraocular pressure	1.4	2.3	4.1	1.2	1.8	-2.0	0.8
Delta distance traveled before/after self-admin	0.8	0.9	1.9	1.4	0.6	-1.1	-0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.5	-0.3	-0.2	0.1
Parametrial fat weight	1.4	3.3	9.0	1.7	0.7	-0.9	-3.0
Pavlov. Cond. lever latency	0.2	0.2	0.4	-0.1	0.7	-0.3	0.5
Pavlov. Cond. magazine entry latency	0.4	0.5	1.4	1.2	-0.6	0.3	-0.3
Pavlov. Cond. change in total contacts	0.5	0.6	1.5	-0.1	-1.2	0.9	-0.1
Pavlov. Cond. index score	0.4	0.5	1.1	0.3	-1.1	0.8	-0.2
Pavlov. Cond. latency score	0.3	0.3	0.8	0.2	-0.9	0.7	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	0.1	-0.4	0.2	-0.2
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	-0.9	0.8	-0.4	0.5
Pavlov. Cond. intertrial magazine entries	1.2	1.5	2.1	0.9	1.3	-1.5	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.2	0.1	-1.5	1.2	-0.2
Pavlov. Cond. response bias	0.3	0.3	0.6	0.7	-0.8	0.5	-0.2
Pavlov. Cond. lever latency	0.4	0.6	1.4	0.2	1.2	-0.5	-0.8
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	-0.8	-0.5	0.5	1.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.3	-0.5	0.2	-0.3	0.2
Pavlov. Cond. index score	0.2	0.3	0.8	-0.4	-0.4	0.2	0.9
Pavlov. Cond. latency score	0.1	0.2	0.4	-0.4	-0.5	0.3	0.7
Pavlov. Cond. lever contacts	0.3	0.5	0.9	-0.2	-0.9	0.4	1.0
Pavlov. Cond. magazine entry number	0.2	0.3	0.8	0.9	0.4	-0.4	-0.3
Pavlov. Cond. intertrial magazine entries	0.4	1.0	1.8	1.3	1.0	-0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	-0.6	-0.3	0.2	0.9
Pavlov. Cond. response bias	0.4	0.5	1.0	-0.4	-1.0	0.5	0.9
Time in closed arm before self-admin	0.3	0.5	1.0	0.8	-1.0	0.6	-0.3
Time in closed arm after self-admin	1.8	2.0	3.2	-1.8	-1.7	1.4	0.2
Time in open arm before self-admin	1.4	1.7	2.5	1.3	1.6	-1.6	-0.6
Time in open arm after self-admin	2.4	2.6	6.1	2.5	1.2	-1.6	-0.7
Bone: periosteal estimation	0.8	1.9	4.6	-0.5	-2.2	1.6	-0.4
Bone: periosteal perimeter	0.5	1.1	2.7	-0.0	-1.6	1.1	-0.6
Bone: post-yield work	1.0	1.7	3.6	-0.3	-1.9	1.6	0.9
Progressive ratio test 1 active lever presses	0.4	0.7	1.0	-1.0	0.9	0.5	0.9
Progressive ratio test 1 breakpoint	0.4	0.7	1.0	-1.0	1.0	0.5	0.9
Progressive ratio test 1 inactive lever presses	1.6	4.3	8.9	-3.0	-1.3	1.7	1.9
Progressive ratio test 2 active lever presses	0.6	0.8	1.5	-1.2	1.0	0.2	0.8
Progressive ratio test 2 breakpoint	0.6	0.7	1.3	-1.1	1.0	0.2	0.7
Progressive ratio test 2 inactive lever presses	0.5	1.6	4.3	-2.1	0.7	0.9	0.9
Incentive Sensitization - Responses	0.3	0.7	2.3	-1.5	0.5	-0.1	0.5
Incentive Sensitization - Breakpoint	0.3	0.6	2.0	-1.4	0.4	-0.1	0.5
Sum of active levers in priming session hrs 5-6	2.8	2.6	3.8	1.2	1.6	-2.0	-1.6
Progressive ratio	0.1	0.2	0.5	-0.0	0.1	0.7	0.7
Food seeking constrained by brief footshock	0.5	0.6	1.2	0.5	-1.0	0.1	1.1
Seeking ratio, punishment vs. effort	0.1	0.3	0.9	0.3	0.2	-1.0	-0.2
Retroperitoneal fat weight	0.6	2.7	8.1	1.3	0.6	-0.8	-2.8
Reaction time number correct	0.1	0.3	0.6	-0.4	-0.8	0.4	0.3
Reaction time mean minus median	0.8	5.4	8.1	2.3	2.5	-2.9	-1.5
Reaction time mean minus median AUC	0.8	5.2	7.5	2.4	2.0	-2.7	-1.8
Reaction time num false alarms	0.1	0.2	0.4	-0.6	0.3	-0.1	0.5
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.4	0.5	-0.0	0.4
Reaction time trials correct on left	0.1	0.3	0.6	-0.4	-0.8	0.4	0.3
Reaction time trials on left	0.1	0.2	0.6	-0.3	-0.8	0.3	0.3
Reaction time mean	2.6	5.8	10.0	2.1	3.2	-2.8	-1.0
Reaction time mean AUC	2.4	5.9	8.4	2.4	2.9	-2.8	-1.3
Median of all reaction times	2.8	4.4	8.7	1.7	2.9	-2.4	-0.5
Reaction time omissions	0.2	0.4	0.9	0.7	0.0	-1.0	-0.1
Reaction time false alarm rate	0.3	0.4	1.2	-0.1	1.1	-0.5	0.1
Reaction time premature initiation rate	0.3	0.4	1.0	-1.0	-0.6	0.1	-0.7
Reaction time premature initiations	0.2	0.6	1.0	-0.9	-1.0	0.3	-0.6
Std. dev. reaction times	1.5	4.9	7.5	1.9	2.7	-2.7	-1.2
Reaction time trials completed	0.1	0.2	0.6	-0.3	-0.8	0.3	0.3
Reaction time trials AUC	0.1	0.2	0.5	-0.3	-0.7	0.3	0.5
Run reversals in cocaine runway, females	0.9	1.0	2.0	-1.1	-1.4	0.9	0.4
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.5	-0.4	0.6	-0.2
Latency to leave start box in cocaine runway	2.1	2.9	5.3	1.5	2.3	-1.9	-0.5
Latency to leave start box in cocaine runway, F	1.1	1.4	4.0	0.4	2.0	-1.2	-0.5
Latency to leave start box in cocaine runway, M	1.6	1.6	2.7	1.6	1.0	-1.6	-0.1
Std. dev. time between licks in bursts	0.7	1.4	4.5	0.2	-1.0	0.4	-2.1
Total sessions with >9 infusions	2.7	3.3	7.3	-2.7	-0.6	1.8	1.5
Short access day 1 total inactive lever presses	2.8	5.6	8.0	-2.8	-1.2	2.3	2.7
Short access day 10 total inactive lever presses	0.4	3.0	6.9	-2.6	-1.3	1.2	1.4
Short access day 1 total infusions	2.5	5.0	10.3	-3.2	-0.4	2.1	2.3
Short access day 10 total infusions	2.2	3.7	9.0	-3.0	-0.3	1.8	1.5
Short access total infusions	3.6	5.0	10.7	-3.3	-0.4	2.3	2.0
Short access day 1 locomotion	0.4	0.7	2.5	-0.4	0.2	0.3	1.6
Short access day 10 total locomotion	0.2	0.7	1.2	-0.8	-1.1	0.9	0.4
Short access total locomotion	0.1	0.2	0.3	-0.4	-0.3	0.6	0.5
One hour access (0.3 mA shock)	0.9	1.1	1.6	-1.2	0.7	0.7	1.3
Compulsive drug intake	0.5	0.8	2.2	0.9	-1.5	0.4	-0.1
One hour access (shock baseline)	0.4	1.1	2.0	-1.4	1.4	0.3	0.7
Social response proportion	0.3	0.4	0.6	-0.0	0.6	-0.8	0.7
Social responses	0.4	0.5	1.6	-0.4	-0.3	-0.2	1.3
Social time	0.5	0.7	1.1	0.8	1.1	-0.9	-0.7
Soleus weight	0.2	0.6	1.0	-0.7	-1.0	0.8	0.4
Bone: stiffness	1.3	2.3	4.9	-0.6	-2.2	2.0	0.2
Tibialis anterior weight	0.1	0.4	0.8	0.6	-0.6	0.2	0.9
Time to tail flick, vehicle, before self-admin	2.2	2.7	5.1	0.8	2.3	-1.9	-1.3
Time to tail flick, vehicle, after self-admin	0.7	1.5	3.0	1.0	0.6	-1.2	-1.7
Time to tail flick, test, before self-admin	0.4	0.4	0.8	-0.7	-0.9	0.4	0.6
Time to tail flick, test, after self-admin	1.3	1.4	2.7	-1.6	-0.7	1.3	0.8
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	1.1	-1.0	-0.9	0.6	0.3
Delta time to tail flick, test, before/after SA	0.2	0.3	0.7	-0.6	0.1	0.8	0.2
Tibia length	0.2	0.5	0.9	-0.3	0.7	-0.7	1.0
Ambulatory time before self-admin	0.0	0.1	0.2	0.1	-0.5	0.1	-0.0
Ambulatory time after self-admin	0.5	0.7	1.6	1.3	-0.9	-0.3	-0.7
Bone: tissue strength	0.3	0.3	1.0	-0.0	-0.3	0.0	1.0
Total heroin consumption	2.8	3.4	7.6	2.8	-0.6	-1.2	-2.0
Bone: trabecular number	2.5	4.7	6.6	-1.7	-2.0	2.3	2.6
Bone: trabecular spacing	3.6	5.2	6.9	2.2	2.3	-2.6	-2.1
Bone: trabecular thickness	1.1	1.6	2.1	-1.2	-1.3	1.4	1.0
Bone: trabecular tissue density	0.3	0.6	2.1	1.4	-0.1	-0.2	-0.4
Water consumed over 24 hours	0.2	0.4	1.1	0.5	-0.7	0.1	-1.0
Number of responses in last shaping day	1.4	1.8	3.3	-1.8	-0.8	1.7	0.7