Hub : Genes

Adh1c

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Adh1c	0.13	0.06	5.3e-11	0.06	0.06	0.06	0.07	1.0e-06	1.2e-07	1.9e-07	3.0e-08
2	Eye	gene expression	Adh1c	0.46	0.18	2.5e-03	0.12	0.02	0.06	0.08	6.9e-03	1.4e-01	5.0e-02	2.5e-02
3	Liver	gene expression	Adh1c	0.46	0.13	0.0e+00	0.32	0.31	0.31	0.32	8.7e-36	4.4e-35	7.6e-35	6.6e-36
4	Liver	mRNA stability	Adh1c	0.1	0.05	4.1e-08	0.06	0.06	0.06	0.06	1.4e-07	3.1e-07	6.7e-07	2.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.0	1.9	2.5	-1.2	-1.6	1.2	1.4
Area under the delay curve	0.1	0.1	0.2	-0.3	-0.2	0.4	0.3
BMI with tail	0.6	2.1	3.8	2.0	1.0	-1.3	-1.3
BMI without tail	0.6	2.9	5.5	2.3	0.9	-1.5	-1.8
Body weight	1.2	5.1	8.2	2.9	1.7	-2.2	-2.1
Weight adjusted by age	0.0	0.0	0.1	-0.0	0.1	0.1	0.2
Bone surface	0.4	0.8	1.3	-0.7	-1.1	0.7	1.0
Bone volume	0.2	0.4	1.0	-0.4	-1.0	0.3	0.6
Breakpoint value in progressive ratio session	0.2	0.4	0.8	-0.5	-0.2	0.7	0.9
Number of licking bursts	0.1	0.3	0.9	-0.1	1.0	-0.1	0.4
Context. condit. distance diff. score	0.7	0.8	1.2	-1.1	-0.3	1.0	1.0
Locomotion velocity, session 1	2.5	2.8	3.8	1.8	1.9	-1.5	-1.4
Locomotion distance, session 1	1.7	2.2	4.7	1.3	2.2	-1.2	-1.0
Locomotion velocity, session 2	0.1	0.1	0.2	0.1	0.3	0.2	0.5
Locomotion distance, session 2	2.3	3.3	6.7	1.6	2.6	-1.4	-1.3
Locomotion velocity, session 3	3.0	3.5	5.8	1.5	2.4	-1.9	-1.5
Locomotion distance, session 3	0.1	0.2	0.6	0.0	0.8	-0.1	0.1
Stereotopy head waving bouts, day 3	1.9	2.3	2.4	1.4	1.6	-1.6	-1.5
Stereotopy head waving duration, day 3	2.1	2.6	3.0	1.6	1.7	-1.7	-1.4
Locomotion velocity, session 7	0.5	0.6	1.2	0.7	1.1	-0.5	-0.7
Locomotion distance, session 7	0.2	0.3	0.3	-0.3	0.6	0.6	0.6
Stereotopy head waving bouts, day 7	1.8	2.1	3.0	1.1	1.2	-1.6	-1.7
Stereotopy head waving duration, day 7	2.5	3.1	4.1	1.4	1.6	-2.0	-2.0
Locomotion velocity, session 8	0.1	0.1	0.3	0.2	0.6	-0.1	-0.3
Locomotion distance, session 8	0.8	1.2	4.1	0.7	2.0	-0.5	-0.2
Degree of sensitization distance	0.7	0.7	1.2	-0.7	-0.7	1.1	0.9
Degree of sensitization stereotypy	1.0	1.1	2.1	0.8	0.6	-1.2	-1.4
Conditioned locomotion	0.2	0.2	0.5	-0.0	-0.7	0.0	-0.5
Cocaine response after cond. corrected	0.0	0.0	0.1	0.2	-0.3	-0.1	-0.2
Cocaine response after cond. not corrected	0.3	0.5	1.2	-0.3	-1.1	0.7	0.3
Cocaine response before conditioning	0.2	0.2	0.5	-0.3	-0.5	0.7	0.3
Saline control response	1.9	2.7	3.1	1.3	1.8	-1.7	-1.8
Bone: connectivity density	2.7	4.2	5.8	-2.0	-1.8	2.0	2.4
Bone: cortical apparent density	0.0	0.1	0.2	0.2	0.4	-0.0	-0.1
Bone: cortical area	0.3	0.5	0.9	1.0	-0.0	-0.8	-0.6
Bone: cortical porosity	1.2	1.4	1.7	1.3	0.9	-1.2	-1.2
Bone: cortical porosity	1.9	2.1	2.8	1.7	1.1	-1.5	-1.5
Bone: cortical thickness	0.2	0.3	0.5	0.7	-0.3	-0.6	-0.3
Bone: cortical thickness	0.4	0.5	1.0	1.0	-0.7	-0.4	-0.6
Bone: cortical tissue density	0.1	0.1	0.3	0.2	0.5	-0.1	-0.1
Condit. Reinf. active minus inactive responses	2.3	2.6	4.3	1.5	2.1	-1.4	-1.4
Condit. Reinf. active-inactive response ratio	4.0	4.3	6.0	2.1	2.4	-1.9	-1.7
Condit. Reinf. active responses	1.0	1.3	2.4	0.9	1.5	-0.8	-1.1
Condit. Reinf. inactive responses	0.2	0.2	0.4	-0.7	-0.6	0.5	-0.1
Incentive salience index mean	1.0	1.2	2.0	1.1	1.4	-0.9	-1.0
Condit. Reinf. lever presses	0.1	0.1	0.1	0.1	0.3	-0.3	-0.4
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	0.1	-0.5	-0.2	-0.1
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.2
Condit. Reinf. active responses	0.1	0.1	0.2	0.4	-0.5	-0.2	-0.1
Condit. Reinf. inactive responses	0.2	0.4	0.8	0.9	0.4	-0.6	-0.5
Condit. Reinf. lever presses	0.2	0.3	0.9	-0.1	-0.9	0.4	0.3
Condit. Reinf. lever reinforcers received	0.1	0.1	0.4	0.2	-0.7	-0.0	0.0
Conditioned reinforcement - actives	0.5	2.2	4.8	0.4	2.2	-1.6	-1.1
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.2	0.2	-0.2	-0.3
Conditioned locomotion	0.7	1.1	2.6	-1.6	-0.5	0.7	1.1
Patch foraging indifference point 0 sec	0.5	1.3	2.0	-1.4	-0.3	1.1	1.4
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1
Delay disc. indifference point, 0s delay	0.7	0.8	1.6	-1.3	-0.6	0.6	0.9
Delay disc. indifference point, 16s delay	0.0	0.0	0.2	0.1	0.4	-0.0	0.1
Delay disc. indifference point, 2s delay	0.5	0.6	1.3	-1.1	-0.7	0.5	0.4
Delay disc. indifference point, 24s delay	0.5	0.7	1.1	-0.8	-1.1	0.8	0.7
Delay disc. indifference point, 4s delay	0.7	0.7	1.1	-0.7	-0.8	1.0	0.8
Delay disc. indifference point, 8s delay	0.5	0.9	1.1	0.9	1.0	-0.8	-1.0
Indifference point function ln k	0.2	0.6	1.5	0.8	1.2	-0.6	-0.4
Indifference point function log k	0.2	0.6	1.5	0.8	1.2	-0.6	-0.4
Patch foraging total patch changes 0 sec	0.4	1.2	1.8	-1.3	-0.2	1.1	1.3
Patch foraging total patch changes 12 sec	0.4	0.5	0.7	-0.6	-0.6	0.7	0.8
Patch foraging total patch changes 18 sec	0.3	0.7	1.4	-1.0	-0.1	0.8	1.2
Patch foraging total patch changes 24 sec	0.1	0.5	1.4	0.1	1.2	-0.6	-0.4
Patch foraging total patch changes 6 sec	2.0	3.4	4.3	-1.9	-1.4	2.0	2.1
Patch foraging time to switch 0 sec	0.0	0.1	0.3	-0.5	-0.4	0.1	0.2
Patch foraging water rate 0 sec	0.0	0.0	0.1	0.1	0.0	0.2	0.2
Patch foraging water rate 12 sec	0.5	2.1	2.6	1.6	1.5	-1.2	-1.4
Patch foraging water rate 18 sec	0.0	0.1	0.2	0.3	-0.2	0.2	0.5
Patch foraging water rate 24 sec	0.2	0.3	0.8	0.5	0.9	-0.1	-0.1
Patch foraging water rate 6 sec	2.0	2.9	4.8	2.2	1.9	-1.2	-1.3
Seeking ratio, delayed vs. immediate footshock	2.2	3.1	4.4	-1.7	-2.1	1.7	1.5
Distance traveled before self-admin	0.0	0.1	0.3	0.1	-0.1	-0.5	-0.2
Distance traveled after self-admin	0.0	0.1	0.1	-0.2	0.4	0.0	0.2
Extensor digitorum longus weight	4.7	18.8	26.1	5.1	2.8	-4.6	-4.5
Bone: elastic displacement	0.5	0.6	0.8	0.9	0.4	-0.8	-0.9
Bone: elastic work	0.6	0.8	1.4	1.2	0.2	-0.9	-0.9
Bone: endosteal estimation	0.0	0.1	0.2	0.4	0.2	-0.4	-0.3
Bone: endosteal perimeter	0.4	0.9	1.2	0.9	0.8	-1.1	-1.1
Epididymis fat weight	0.2	1.3	1.3	1.2	1.1	-1.1	-1.1
Delta time in closed arm before/after self-admin	1.9	1.8	3.0	1.1	1.7	-1.3	-1.2
Delta time in open arm before/after self-admin	1.9	2.3	3.1	0.9	1.5	-1.8	-1.7
Diff in mean of infusions in LGA sessions	1.6	2.8	4.3	-1.4	-1.2	2.1	1.9
Delay discount exponential model param	0.1	0.2	0.3	0.4	0.3	-0.5	-0.3
Extinction: sum of active levers before priming	0.2	0.4	0.6	-0.0	-0.8	0.6	0.6
Active lever presses in extinction session 6	1.9	2.0	2.7	-1.6	-0.6	1.5	1.6
Bone: final force	0.1	0.1	0.1	0.3	0.1	-0.3	-0.4
Bone: final moment	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.2
Food consumed during 24 hour testing period	0.5	1.0	2.3	1.5	0.8	-0.9	-0.6
Glucose	0.1	0.2	0.6	0.8	0.0	0.1	-0.5
Heart weight	0.7	1.1	1.7	1.3	0.5	-1.2	-1.0
Delay discount hyperbolic model param	0.2	0.2	0.3	0.5	0.4	-0.6	-0.4
Intermittent access intake day 1-15 change	0.1	0.3	0.5	-0.3	-0.7	0.3	0.7
Intermittent access intake escalation	0.2	1.3	1.8	-0.9	-1.3	0.9	1.3
Intermittent access intake escalation 2	0.7	1.2	1.9	-0.8	-1.4	0.8	1.3
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.5	0.7	0.3	-0.2	-0.4
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.7	1.3	0.4	-0.9	-1.0
Intermitt. access escalation Index	0.2	0.6	1.0	0.7	0.0	-0.9	-1.0
Intermittent access day 1 total infusions	0.3	1.0	1.3	1.1	1.1	-0.6	-1.0
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.2	-0.2	0.2	0.4
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.4	0.6	0.6	-0.3	0.0
Intermittent access total infusions	0.5	0.6	1.0	0.9	1.0	-0.5	-0.4
Intermittent access day 1 locomotion	0.2	0.3	0.6	0.6	0.8	-0.5	-0.5
Intermittent access day 15 total locomotion	0.2	0.8	1.2	-0.9	-0.8	0.7	1.1
Intermittent access total locomotion	0.1	0.1	0.2	-0.2	-0.2	0.2	0.5
Intermittent access standard deviation	0.0	0.0	0.1	0.1	-0.0	-0.1	0.3
Left kidney weight	0.3	2.3	4.0	2.0	0.9	-1.5	-1.4
Right kidney weight	0.4	2.8	4.2	2.1	1.1	-1.8	-1.6
Cocaine induced anxiety	0.1	0.2	0.3	-0.5	-0.1	0.3	0.5
Post-drug Anxiety	0.3	0.4	0.6	-0.7	-0.4	0.5	0.7
Baseline Anxiety	0.1	0.2	0.4	0.6	0.1	-0.4	-0.3
Tail length	0.1	0.7	0.9	0.9	0.5	-0.9	-0.9
Length with tail	0.4	1.7	2.4	1.6	1.0	-1.3	-1.3
Length without tail	0.1	0.5	0.8	0.7	0.9	-0.7	-0.4
Times rat made contact with spout	1.1	1.2	1.8	-0.7	-1.0	1.3	1.3
Lifetime Intake	0.7	0.9	1.7	1.0	1.3	-0.7	-0.7
Liver weight, left	0.2	0.4	0.6	0.3	0.8	-0.8	-0.5
Liver weight, right	0.0	0.1	0.2	-0.2	0.4	-0.2	0.2
Locomotor activity	0.1	0.2	0.3	0.0	-0.5	0.5	0.5
Locomotor testing distance	0.0	0.1	0.4	0.6	-0.1	0.2	-0.0
Locomotor testing rearing	0.3	1.2	2.6	-0.1	-0.9	1.6	1.1
Locomotion in novel chamber	7.4	9.9	10.9	-3.2	-3.3	3.1	3.0
Locomotion in novel chamber post-restriction	0.0	0.1	0.3	0.1	-0.6	0.4	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.5	0.7	0.3	0.9	-0.6	-0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.2	-0.6	0.6	0.4
Time >=10cm from walls, locomotor time 1	3.1	3.9	5.0	-1.8	-1.6	2.1	2.2
Bouts of movement, locomotor time 1	0.6	0.8	0.9	-0.6	-1.0	0.9	0.9
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.3	-0.5	0.5	0.5
Rest time, locomotor task time 1	0.3	0.6	1.0	0.7	0.3	-1.0	-0.8
Distance moved, locomotor task time 1	0.1	0.2	0.3	-0.1	-0.3	0.6	0.6
Vertical activity count, locomotor time 1	0.1	0.6	0.9	-0.7	-0.5	0.9	1.0
Time >=10cm from walls, locomotor time 2	0.8	2.3	2.4	1.6	1.5	-1.5	-1.5
Bouts of movement, locomotor time 2	0.3	1.1	1.3	-1.1	-1.0	1.1	1.0
Total resting periods, locomotor time 2	0.3	1.3	1.5	-1.2	-1.1	1.1	1.0
Rest time, locomotor task time 2	0.4	0.6	1.6	-0.6	-1.3	0.6	0.5
Distance moved, locomotor task time 2	0.2	0.3	0.8	0.3	0.9	-0.5	-0.2
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.0	0.3	-0.2	-0.0
Light reinforcement 1	0.3	1.3	2.2	1.5	1.3	-1.0	-0.7
Light reinforcement 2	0.0	0.1	0.3	0.5	-0.1	-0.3	-0.1
Bone: marrow area	0.0	0.1	0.1	0.3	0.1	-0.2	-0.2
Bone: maximum diameter	0.0	0.0	0.1	0.3	-0.2	-0.2	0.1
Bone: maximum force	0.0	0.1	0.2	0.2	0.3	-0.4	-0.1
Bone: maximum moment	0.0	0.0	0.0	0.1	-0.0	-0.1	0.1
Mean time between licks in bursts	0.0	0.2	0.6	-0.4	0.1	0.3	0.8
Mean num. licks in bursts	0.3	0.9	2.5	-0.3	-1.6	0.9	0.3
Cd content in liver	0.0	0.0	0.1	-0.2	0.3	0.2	0.2
Co content in liver	5.1	5.9	6.4	2.5	2.5	-2.5	-2.2
Cu content in liver	2.5	3.0	3.9	-1.8	-1.1	1.9	2.0
Fe content in liver	0.1	0.1	0.5	-0.7	-0.3	-0.1	-0.1
K content in liver	2.1	2.0	2.7	-1.5	-1.3	1.6	1.1
Mg content in liver	0.7	0.8	1.3	-1.0	-0.5	1.2	0.8
Mn content in liver	0.6	0.7	1.2	-0.3	-1.1	1.0	0.6
Na content in liver	0.5	0.6	0.7	-0.8	-0.6	0.8	0.8
Rb content in liver	0.3	0.4	1.0	0.1	1.0	-0.5	-0.6
Se content in liver	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2
Sr content in liver	0.4	0.4	1.1	0.2	-1.1	0.3	-0.5
Zn content in liver	29.5	34.4	40.1	-6.3	-4.7	6.2	6.0
Bone: minimum diameter	1.6	3.1	4.6	2.1	1.3	-1.8	-1.7
Time in familiar zone, hab. session 1	0.3	0.4	0.7	0.2	0.8	-0.8	-0.4
Time in novel zone, hab. session 1	0.1	0.1	0.5	-0.1	-0.7	0.3	-0.1
Total zone transitions, hab. session 1	3.9	5.4	8.6	2.0	2.9	-2.3	-2.0
Total locomotion distance, hab. session 1	0.4	0.6	1.7	0.5	1.3	-0.7	-0.2
Locomotion velocity, hab. session 1	0.2	0.3	0.9	0.4	1.0	-0.4	-0.0
Time in familiar zone, hab. session 2	0.6	0.7	2.7	0.1	-1.6	0.4	0.2
Time in novel zone, hab. session 2	0.3	0.3	1.2	-0.3	1.1	-0.2	0.1
Total zone transitions, hab. session 2	1.9	2.4	5.2	1.3	2.3	-1.4	-1.1
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.4	0.6	0.0	-0.0
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.2	0.6	0.1	0.1
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.0	0.0	0.3	0.4
Novelty place preference	0.1	0.1	0.3	0.0	-0.2	0.4	0.5
Time in novel zone, NPP test	0.1	0.1	0.3	0.0	-0.2	0.5	0.5
Total zone transitions, NPP test	1.6	2.3	4.2	1.5	2.0	-1.3	-1.1
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.1	0.4	0.3	0.5
Locomotion velocity, NPP test	0.1	0.1	0.3	0.0	0.3	0.4	0.5
Intraocular pressure	0.1	0.2	0.5	0.1	-0.0	-0.7	-0.6
Delta distance traveled before/after self-admin	0.1	0.1	0.5	-0.1	0.7	0.3	0.2
Delta ambulatory time before/after self-admin	0.1	0.2	0.2	-0.3	0.4	0.5	0.5
Parametrial fat weight	0.2	0.5	0.6	-0.8	-0.6	0.7	0.7
Pavlov. Cond. lever latency	0.8	1.1	1.6	1.3	0.6	-0.9	-1.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.0	0.4	0.8	-0.8	-1.0
Pavlov. Cond. change in total contacts	0.2	0.2	0.4	-0.5	0.7	0.2	0.2
Pavlov. Cond. index score	0.3	0.4	0.7	-0.8	-0.4	0.6	0.6
Pavlov. Cond. latency score	0.5	0.7	1.1	-1.0	-0.5	0.8	0.9
Pavlov. Cond. lever contacts	0.7	0.8	1.2	-1.1	-0.5	0.8	1.1
Pavlov. Cond. magazine entry number	0.8	1.0	1.6	-0.7	-1.3	1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.3	-0.6	-0.2	0.3	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.8	-0.9	-0.6	0.9	0.7
Pavlov. Cond. response bias	0.2	0.3	0.8	0.0	0.9	-0.5	-0.3
Pavlov. Cond. lever latency	0.5	0.7	1.0	-1.0	-0.9	0.8	0.6
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.2	-0.2	0.0	-0.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.1	-0.0	0.2	0.5
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.5	-0.3	0.3	0.4
Pavlov. Cond. lever contacts	0.5	0.8	1.2	1.1	0.8	-1.0	-0.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.2	0.2	-0.0	-0.0
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.9	0.1	-0.9	0.3	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.2	-0.3	0.0	0.2
Pavlov. Cond. response bias	1.0	1.4	1.9	1.4	0.9	-1.3	-1.1
Time in closed arm before self-admin	0.1	0.2	0.4	-0.5	0.1	0.4	0.6
Time in closed arm after self-admin	0.8	0.9	1.7	-0.9	-0.3	1.0	1.3
Time in open arm before self-admin	0.4	0.5	1.1	0.2	-1.0	0.8	0.4
Time in open arm after self-admin	1.0	1.1	1.7	0.8	0.8	-1.2	-1.3
Bone: periosteal estimation	0.3	0.7	1.3	1.1	0.2	-0.9	-0.7
Bone: periosteal perimeter	0.8	1.6	2.1	1.4	0.8	-1.4	-1.3
Bone: post-yield work	0.3	0.5	1.3	-1.1	0.2	0.3	0.8
Progressive ratio test 1 active lever presses	1.9	3.4	4.3	2.1	2.0	-1.5	-1.7
Progressive ratio test 1 breakpoint	1.7	2.9	3.7	1.9	1.9	-1.4	-1.5
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.7	-0.0	-0.1	-0.7
Progressive ratio test 2 active lever presses	1.7	2.4	3.5	1.9	1.3	-1.5	-1.4
Progressive ratio test 2 breakpoint	1.3	1.7	2.9	1.7	1.0	-1.3	-1.2
Progressive ratio test 2 inactive lever presses	0.4	1.2	1.6	1.1	1.0	-1.3	-1.1
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.1	-0.2	-0.4	0.1
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	-0.1	-0.4	-0.4	0.1
Sum of active levers in priming session hrs 5-6	4.2	3.9	5.0	-1.5	-2.2	2.1	2.0
Progressive ratio	0.1	0.2	0.4	0.3	-0.6	-0.2	-0.5
Food seeking constrained by brief footshock	0.1	0.2	0.5	0.7	0.2	-0.3	-0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.1	0.5	0.2	0.4
Retroperitoneal fat weight	0.1	0.3	0.6	0.8	-0.3	-0.3	-0.5
Reaction time number correct	0.0	0.1	0.1	0.4	-0.4	0.1	-0.0
Reaction time mean minus median	0.0	0.1	0.3	-0.3	-0.5	-0.2	-0.3
Reaction time mean minus median AUC	0.0	0.2	0.5	-0.5	-0.7	0.1	-0.0
Reaction time num false alarms	1.1	1.9	2.4	0.8	1.5	-1.5	-1.5
Reaction time num false alarms AUC	1.3	3.0	3.7	1.2	1.8	-1.9	-1.9
Reaction time trials correct on left	0.0	0.1	0.1	0.4	-0.4	0.1	-0.0
Reaction time trials on left	0.0	0.1	0.2	0.3	-0.4	0.1	-0.0
Reaction time mean	0.1	0.2	0.7	0.1	-0.9	0.1	-0.2
Reaction time mean AUC	0.1	0.2	0.5	0.4	-0.7	-0.1	-0.4
Median of all reaction times	0.1	0.2	0.5	0.5	-0.7	0.1	-0.2
Reaction time omissions	0.3	0.6	1.1	-0.9	-1.1	0.4	0.2
Reaction time false alarm rate	1.1	1.5	2.0	0.6	1.4	-1.4	-1.4
Reaction time premature initiation rate	2.3	3.5	3.6	1.8	1.9	-1.9	-1.9
Reaction time premature initiations	1.4	4.1	4.7	2.2	1.8	-2.0	-2.1
Std. dev. reaction times	0.1	0.3	0.8	-0.7	-0.9	0.2	0.1
Reaction time trials completed	0.0	0.1	0.2	0.3	-0.4	0.1	-0.0
Reaction time trials AUC	0.0	0.1	0.1	0.4	-0.3	0.0	-0.1
Run reversals in cocaine runway, females	0.4	0.4	0.9	-0.3	-0.6	0.9	0.6
Run reversals in cocaine runway, males	0.1	0.2	0.5	0.7	0.1	0.3	-0.2
Latency to leave start box in cocaine runway	0.8	1.1	1.8	-1.0	-0.5	1.3	1.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.3	-0.4	0.6	0.3	0.4
Latency to leave start box in cocaine runway, M	3.2	3.1	4.2	-1.4	-1.8	2.0	1.7
Std. dev. time between licks in bursts	0.3	0.5	1.1	-0.4	0.8	0.5	1.0
Total sessions with >9 infusions	1.3	1.6	4.2	0.8	2.1	-1.0	-0.9
Short access day 1 total inactive lever presses	0.1	0.1	0.6	0.0	0.8	0.1	0.0
Short access day 10 total inactive lever presses	0.1	0.6	1.1	-1.1	-0.6	0.7	0.6
Short access day 1 total infusions	0.7	1.3	3.8	0.4	2.0	-1.0	-0.6
Short access day 10 total infusions	0.5	0.9	1.9	0.9	1.4	-0.5	-0.8
Short access total infusions	0.8	1.2	2.8	0.9	1.7	-0.7	-0.8
Short access day 1 locomotion	0.5	0.8	2.9	0.1	1.7	-0.5	0.1
Short access day 10 total locomotion	0.1	0.3	0.7	-0.4	-0.3	0.6	0.8
Short access total locomotion	0.2	0.4	0.7	-0.6	0.0	0.7	0.8
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.0	-0.4	0.3	0.3
Compulsive drug intake	0.5	0.8	2.4	-0.3	-1.5	0.8	0.4
One hour access (shock baseline)	0.1	0.3	0.4	0.7	0.6	-0.4	-0.4
Social response proportion	0.2	0.3	0.5	-0.7	-0.5	0.2	-0.5
Social responses	0.9	1.2	1.6	-0.9	-1.3	1.3	0.8
Social time	1.2	1.9	2.9	-1.7	-1.5	1.2	1.0
Soleus weight	1.3	3.7	4.9	2.1	1.3	-2.0	-2.2
Bone: stiffness	0.0	0.1	0.1	0.4	0.3	-0.3	-0.1
Tibialis anterior weight	4.6	15.7	25.3	5.0	2.3	-4.0	-4.0
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.4	0.2	-0.1	-0.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.5	-0.1	-0.4	-0.2
Time to tail flick, test, before self-admin	0.3	0.4	0.6	-0.8	-0.8	0.4	0.4
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.3	0.2	-0.1	0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.2	0.3	-0.3	-0.1
Delta time to tail flick, test, before/after SA	0.4	0.5	0.9	0.7	0.9	-0.6	-0.4
Tibia length	0.4	1.0	2.0	1.4	0.0	-1.0	-1.1
Ambulatory time before self-admin	0.0	0.1	0.3	0.1	-0.0	-0.5	-0.3
Ambulatory time after self-admin	0.1	0.2	0.4	-0.5	0.6	-0.1	0.2
Bone: tissue strength	0.0	0.0	0.1	-0.1	0.4	-0.0	0.1
Total heroin consumption	0.5	0.6	1.0	-0.6	-1.0	0.6	0.7
Bone: trabecular number	0.2	0.4	0.8	-0.9	-0.6	0.3	0.6
Bone: trabecular spacing	0.8	1.2	1.9	-0.6	-1.2	1.4	0.9
Bone: trabecular thickness	0.3	0.5	0.6	0.7	0.6	-0.8	-0.7
Bone: trabecular tissue density	0.4	0.7	1.0	0.8	0.8	-0.7	-1.0
Water consumed over 24 hours	0.0	0.1	0.2	0.4	0.4	-0.2	0.1
Number of responses in last shaping day	3.7	4.8	6.1	1.8	2.5	-2.3	-2.1