Hub : Genes

Adcy1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Adcy1 0.05 0.03 2.6e-03 -0 0.01 0.01 0 5.8e-01 5.4e-03 1.8e-03 2.5e-01
2 Liver intron excision ratio chr14_86231976_86234154 0.05 0.03 1.3e-04 0.01 0.03 0.02 0.02 1.4e-02 2.5e-04 2.4e-03 1.5e-03
3 Brain gene expression Adcy1 0.09 0.05 1.7e-06 0.04 0.06 0.04 0.05 1.1e-04 2.7e-06 7.9e-05 3.4e-05
4 Liver gene expression Adcy1 0.07 0.04 1.2e-04 0.01 0.03 0.02 0.02 2.2e-02 6.8e-04 1.9e-03 1.1e-03
5 IC gene expression Adcy1 0.07 0.04 5.5e-04 0.1 0.07 0.08 0.08 7.7e-05 8.7e-04 2.6e-04 3.7e-04
6 Liver mRNA stability Adcy1 0.2 0.06 0.0e+00 0.19 0.18 0.18 0.19 2.1e-20 7.0e-20 6.7e-20 2.1e-20
7 Adipose gene expression Adcy1 0.36 0.09 0.0e+00 0.15 0.23 0.21 0.19 2.3e-16 1.1e-24 4.5e-23 2.6e-20
8 Brain mRNA stability Adcy1 0.07 0.03 2.3e-06 0.04 0.06 0.05 0.05 1.7e-04 4.4e-06 2.1e-05 1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.01.74.9-0.80.70.42.20.31.7-0.6-2.0
Area under the delay curve3.44.08.40.2-2.7-2.9-0.4-2.22.0-2.0-1.6
BMI with tail0.10.51.40.1-0.8-1.1-0.7-0.50.2-1.2-0.2
BMI without tail0.30.92.30.6-1.1-0.9-1.5-0.6-0.7-0.11.2
Body weight1.67.016.41.4-3.9-4.0-2.3-2.71.3-2.9-0.5
Weight adjusted by age0.30.52.70.6-0.4-0.1-0.0-0.2-0.20.71.7
Bone surface0.20.30.8-0.4-0.1-0.30.9-0.10.9-0.4-0.8
Bone volume0.50.82.2-0.1-0.0-0.41.4-0.31.3-0.8-1.5
Breakpoint value in progressive ratio session1.01.12.30.0-0.9-1.00.7-0.71.5-1.4-1.5
Number of licking bursts2.03.28.3-0.8-1.9-1.90.9-2.92.2-1.0-1.6
Context. condit. distance diff. score0.60.71.8-0.31.31.00.71.30.2-0.4-0.8
Locomotion velocity, session 10.70.72.20.70.60.6-0.81.5-1.00.30.8
Locomotion distance, session 10.30.41.6-1.3-0.10.10.50.2-0.00.9-0.6
Locomotion velocity, session 20.91.13.6-0.71.20.80.91.9-0.2-0.0-1.1
Locomotion distance, session 21.31.83.3-0.61.41.50.01.8-1.71.80.9
Locomotion velocity, session 30.60.72.30.5-0.1-0.7-1.50.9-1.0-1.0-0.2
Locomotion distance, session 32.62.85.22.2-1.6-2.2-2.2-0.4-0.2-2.30.4
Stereotopy head waving bouts, day 31.82.14.3-2.11.61.71.91.40.31.0-0.8
Stereotopy head waving duration, day 32.42.95.8-1.62.32.41.72.1-0.31.4-0.4
Locomotion velocity, session 70.50.61.51.0-0.7-0.7-1.20.5-0.7-0.10.7
Locomotion distance, session 70.30.41.81.3-0.1-0.0-0.40.7-0.40.20.5
Stereotopy head waving bouts, day 70.20.31.1-0.00.60.61.00.20.50.00.1
Stereotopy head waving duration, day 70.30.30.9-0.60.60.70.90.10.30.50.2
Locomotion velocity, session 81.11.32.7-1.61.61.31.50.90.30.6-0.5
Locomotion distance, session 82.43.48.1-0.92.62.5-0.12.9-1.91.40.5
Degree of sensitization distance3.73.89.2-1.02.43.02.01.7-0.52.70.5
Degree of sensitization stereotypy0.10.20.70.8-0.00.10.1-0.20.2-0.10.7
Conditioned locomotion1.01.15.5-1.3-0.4-0.70.4-0.70.4-0.3-2.4
Cocaine response after cond. corrected1.72.05.0-0.6-1.4-1.31.1-1.62.2-1.2-1.3
Cocaine response after cond. not corrected1.41.73.6-0.4-1.7-1.40.7-1.91.8-0.7-0.7
Cocaine response before conditioning0.60.82.10.00.10.4-0.80.3-1.31.41.2
Saline control response0.50.71.5-1.20.10.3-1.10.6-1.20.80.4
Bone: connectivity density0.81.22.8-1.41.11.21.70.80.50.9-0.5
Bone: cortical apparent density0.10.10.50.1-0.10.20.1-0.10.10.40.7
Bone: cortical area1.52.35.60.5-2.3-2.4-1.4-1.90.6-1.10.1
Bone: cortical porosity0.40.41.30.3-0.3-0.8-0.6-0.70.2-1.1-0.5
Bone: cortical porosity0.60.61.70.4-0.6-1.0-1.3-0.8-0.3-1.0-0.2
Bone: cortical thickness1.11.94.9-0.4-2.2-2.2-1.4-1.80.3-0.60.1
Bone: cortical thickness0.50.62.1-1.5-0.7-0.4-0.6-0.1-0.61.0-0.3
Bone: cortical tissue density0.10.10.50.2-0.10.20.1-0.10.10.40.7
Condit. Reinf. active minus inactive responses0.20.21.2-0.1-0.4-0.20.40.21.1-0.4-0.0
Condit. Reinf. active-inactive response ratio1.01.12.71.00.60.31.00.81.5-1.6-0.9
Condit. Reinf. active responses0.10.20.6-0.7-0.4-0.1-0.20.40.30.40.5
Condit. Reinf. inactive responses0.91.13.3-1.5-0.9-0.4-0.6-0.4-0.81.81.1
Incentive salience index mean0.60.72.1-0.7-1.4-1.3-0.8-0.40.7-0.3-0.1
Condit. Reinf. lever presses1.72.47.1-1.2-2.2-2.1-2.7-0.7-0.80.20.3
Condit. Reinf. active minus inactive responses0.40.51.1-0.20.20.5-0.60.6-0.71.01.0
Condit. Reinf. active-inactive response ratio0.40.40.80.9-0.8-0.8-0.8-0.50.0-0.40.5
Condit. Reinf. active responses1.01.42.9-0.71.01.4-0.21.4-1.11.71.2
Condit. Reinf. inactive responses1.82.44.5-1.41.82.10.61.9-1.11.90.7
Condit. Reinf. lever presses0.81.13.00.3-0.4-0.1-1.60.3-1.71.31.2
Condit. Reinf. lever reinforcers received0.71.02.6-0.70.60.9-0.41.1-1.01.61.2
Conditioned reinforcement - actives0.91.59.53.10.60.6-0.10.4-0.7-0.21.3
Conditioned reinforcement - inactives0.40.61.80.6-0.7-0.7-1.3-0.5-0.7-0.50.6
Conditioned locomotion1.72.214.13.80.40.7-0.30.5-0.70.31.5
Patch foraging indifference point 0 sec1.83.36.52.1-2.3-2.00.2-2.62.0-1.4-0.2
Patch foraging indifference point AUC0.40.51.3-0.1-0.1-0.0-1.10.4-1.10.61.1
Delay disc. indifference point, 0s delay2.93.27.50.3-2.0-2.01.0-2.72.2-1.3-1.6
Delay disc. indifference point, 16s delay2.72.98.10.9-1.6-2.0-0.3-1.01.8-2.8-2.0
Delay disc. indifference point, 2s delay4.65.19.2-1.1-2.9-3.00.1-2.92.3-1.7-2.3
Delay disc. indifference point, 24s delay0.91.12.2-0.0-1.4-1.5-0.3-1.11.1-1.3-0.3
Delay disc. indifference point, 4s delay1.81.95.7-0.1-2.4-1.9-0.2-2.01.1-0.0-0.2
Delay disc. indifference point, 8s delay1.11.33.70.3-1.6-1.9-0.9-0.80.8-1.3-0.6
Indifference point function ln k0.20.41.20.2-0.3-0.20.7-0.51.1-0.5-0.7
Indifference point function log k0.20.41.20.2-0.3-0.20.7-0.51.1-0.5-0.7
Patch foraging total patch changes 0 sec1.73.26.12.0-2.4-2.1-0.1-2.51.8-1.4-0.1
Patch foraging total patch changes 12 sec0.70.91.50.9-1.2-1.10.3-1.21.1-0.9-0.0
Patch foraging total patch changes 18 sec1.62.56.02.5-2.1-1.8-1.2-1.60.6-0.90.9
Patch foraging total patch changes 24 sec0.81.44.00.31.11.50.70.5-0.51.62.0
Patch foraging total patch changes 6 sec1.01.53.61.9-1.7-1.3-0.3-1.50.9-0.50.7
Patch foraging time to switch 0 sec0.40.82.5-0.51.11.01.60.40.50.1-0.9
Patch foraging water rate 0 sec0.40.81.61.3-1.3-0.9-0.9-0.70.2-0.00.8
Patch foraging water rate 12 sec0.51.03.11.4-0.5-0.1-1.20.5-0.60.51.8
Patch foraging water rate 18 sec0.71.12.80.5-0.80.0-1.3-0.4-1.01.61.7
Patch foraging water rate 24 sec0.71.02.61.60.20.5-1.21.0-0.90.31.2
Patch foraging water rate 6 sec0.40.51.40.8-0.30.1-1.00.7-0.50.51.2
Seeking ratio, delayed vs. immediate footshock0.40.51.60.70.3-0.0-1.30.6-0.8-0.50.4
Distance traveled before self-admin0.30.41.10.40.70.91.10.2-0.10.70.1
Distance traveled after self-admin0.30.41.2-0.40.1-0.11.0-0.60.7-0.4-1.1
Extensor digitorum longus weight1.76.813.12.5-3.6-3.5-2.9-3.10.5-1.61.5
Bone: elastic displacement0.60.72.1-1.10.1-0.0-1.40.2-1.50.3-0.1
Bone: elastic work0.60.71.4-0.8-1.2-1.0-1.1-1.0-0.30.3-0.5
Bone: endosteal estimation0.40.92.01.4-1.1-1.3-1.2-0.4-0.0-0.9-0.4
Bone: endosteal perimeter0.51.13.00.5-1.7-1.7-1.0-0.90.4-0.7-0.4
Epididymis fat weight1.13.88.12.8-2.2-2.5-1.7-1.50.6-2.4-0.2
Delta time in closed arm before/after self-admin4.94.69.0-1.62.82.80.43.0-2.02.00.8
Delta time in open arm before/after self-admin2.72.75.12.3-2.1-2.2-0.9-2.10.8-1.2-0.1
Diff in mean of infusions in LGA sessions0.70.82.20.0-0.4-0.80.6-0.61.1-1.5-1.3
Delay discount exponential model param3.23.68.1-0.22.72.80.52.2-1.81.81.3
Extinction: sum of active levers before priming1.11.24.11.2-0.5-0.8-2.00.3-1.3-1.00.7
Active lever presses in extinction session 60.40.41.0-0.6-1.0-0.9-1.0-0.2-0.3-0.2-0.4
Bone: final force0.10.10.50.40.0-0.10.3-0.20.7-0.50.2
Bone: final moment0.20.30.80.5-0.2-0.40.2-0.60.9-0.70.1
Food consumed during 24 hour testing period0.40.61.70.7-0.9-0.9-1.3-0.20.1-0.40.6
Glucose3.04.832.05.7-0.4-0.4-0.40.10.8-1.61.5
Heart weight1.01.57.72.8-0.5-0.4-1.40.2-0.6-0.51.2
Delay discount hyperbolic model param3.53.98.9-0.12.93.00.62.2-1.91.91.4
Intermittent access intake day 1-15 change0.81.66.52.6-0.5-0.6-1.4-1.0-0.7-0.61.4
Intermittent access intake escalation0.91.86.82.6-0.8-0.9-1.5-1.1-0.6-0.81.1
Intermittent access intake escalation 21.21.43.91.2-0.6-0.5-2.0-0.8-1.20.11.7
Intermitt. access day 1 inactive lever presses0.10.30.7-0.80.70.3-0.10.3-0.80.10.7
Intermitt. access day 15 inactive lever presses0.61.25.82.4-0.6-0.9-0.9-0.50.1-1.00.7
Intermitt. access escalation Index0.91.23.70.10.40.11.8-0.31.9-1.2-1.1
Intermittent access day 1 total infusions0.30.52.6-1.6-0.2-0.20.5-0.50.20.2-0.8
Intermittent access day 15 total infusions0.60.92.31.5-1.0-0.9-0.8-1.4-0.2-0.40.6
Intermittent access terminal intake (last 3 days)0.71.02.11.2-0.7-0.4-1.4-0.9-0.80.41.5
Intermittent access total infusions0.50.61.01.0-0.9-0.8-1.0-0.9-0.5-0.20.4
Intermittent access day 1 locomotion0.91.12.1-0.31.31.50.51.4-0.81.20.6
Intermittent access day 15 total locomotion0.61.05.02.2-0.40.1-0.90.2-0.80.51.1
Intermittent access total locomotion0.50.61.71.3-0.5-0.1-0.80.0-0.80.71.1
Intermittent access standard deviation2.14.312.20.11.51.6-2.31.7-3.51.42.8
Left kidney weight0.21.12.90.4-1.0-0.4-1.5-0.8-0.70.91.7
Right kidney weight0.20.92.40.1-1.4-1.1-1.5-1.1-0.4-0.10.9
Cocaine induced anxiety0.60.92.10.7-1.4-1.3-0.8-1.50.3-0.3-0.5
Post-drug Anxiety1.31.43.40.4-1.6-1.5-0.1-1.81.1-0.7-0.9
Baseline Anxiety0.20.20.7-0.1-0.3-0.50.5-0.30.7-0.9-0.1
Tail length1.35.012.02.1-3.5-3.1-1.6-2.81.1-1.4-0.0
Length with tail1.56.516.02.2-4.0-3.6-2.0-3.21.2-1.6-0.1
Length without tail0.93.05.61.0-1.7-1.80.9-1.62.4-2.1-1.7
Times rat made contact with spout0.60.71.40.71.11.1-0.51.2-0.60.11.0
Lifetime Intake0.40.41.10.6-0.8-0.8-1.0-0.6-0.6-0.20.3
Liver weight, left0.20.41.1-0.80.1-0.1-0.90.5-1.1-0.3-0.4
Liver weight, right1.12.04.6-0.40.70.6-1.91.2-2.11.12.0
Locomotor activity0.60.92.40.7-1.2-1.3-1.6-0.2-0.1-1.10.1
Locomotor testing distance1.42.55.31.3-2.2-2.3-2.1-1.0-0.1-1.5-0.1
Locomotor testing rearing0.61.22.31.4-1.5-1.5-0.8-0.80.4-1.30.3
Locomotion in novel chamber0.70.96.4-2.5-0.1-0.2-0.1-0.5-0.40.8-0.1
Locomotion in novel chamber post-restriction0.50.82.0-1.01.41.20.41.1-0.40.2-0.6
Fecal boli incidents, locomotor time 10.30.51.4-0.10.70.7-0.40.4-1.21.00.6
Change in fecal boli incidents, locomotor task0.40.42.31.50.1-0.20.00.00.5-0.90.3
Time >=10cm from walls, locomotor time 12.22.39.4-0.61.51.63.10.51.20.5-1.3
Bouts of movement, locomotor time 10.70.81.70.90.30.51.2-0.70.51.11.3
Total resting periods, locomotor time 10.80.93.41.30.40.60.2-0.3-0.31.01.8
Rest time, locomotor task time 10.50.61.51.10.90.8-0.00.8-0.60.21.2
Distance moved, locomotor task time 10.10.20.6-0.4-0.7-0.6-0.80.0-0.40.2-0.2
Vertical activity count, locomotor time 10.40.93.6-0.6-0.6-0.70.5-0.11.1-0.9-1.9
Time >=10cm from walls, locomotor time 21.01.53.2-0.81.51.81.61.0-0.11.3-0.5
Bouts of movement, locomotor time 20.61.02.10.9-1.1-1.1-0.6-1.40.20.11.4
Total resting periods, locomotor time 20.50.92.31.0-1.0-0.9-0.3-1.40.30.31.5
Rest time, locomotor task time 20.60.81.20.81.11.00.31.1-0.70.61.0
Distance moved, locomotor task time 20.30.31.4-1.20.10.1-0.4-0.1-0.60.7-0.0
Vertical activity count, locomotor time 20.71.03.6-1.8-0.3-0.50.4-0.40.8-0.4-1.9
Light reinforcement 10.30.71.40.9-0.7-0.6-1.2-0.1-0.90.41.1
Light reinforcement 21.21.88.7-1.3-0.60.2-0.9-0.1-1.22.91.2
Bone: marrow area0.40.91.81.4-1.0-1.3-1.0-0.40.1-1.0-0.6
Bone: maximum diameter1.73.26.22.2-2.5-2.4-1.4-2.00.9-1.20.8
Bone: maximum force0.10.20.40.1-0.5-0.6-0.3-0.60.3-0.40.1
Bone: maximum moment0.20.41.00.2-0.7-0.8-0.3-1.00.5-0.50.0
Mean time between licks in bursts0.10.30.9-0.9-0.0-0.10.7-0.21.00.1-0.5
Mean num. licks in bursts2.33.79.71.02.22.2-1.03.1-2.10.81.7
Cd content in liver0.70.72.51.2-0.6-0.8-0.6-0.80.3-1.6-0.0
Co content in liver2.12.56.11.1-2.1-2.5-1.7-1.40.2-1.7-0.7
Cu content in liver0.60.72.7-0.90.80.81.70.30.8-0.1-0.1
Fe content in liver0.30.42.0-0.50.60.20.40.5-0.2-0.1-1.4
K content in liver1.71.75.2-2.3-0.8-1.01.2-1.31.2-0.4-1.3
Mg content in liver0.50.51.8-1.3-0.4-0.50.7-0.90.5-0.3-0.3
Mn content in liver0.20.21.2-1.1-0.2-0.3-0.1-0.2-0.50.40.1
Na content in liver1.51.64.10.2-1.7-2.0-0.2-1.81.0-1.1-0.5
Rb content in liver0.70.82.50.9-0.1-0.31.1-0.01.3-1.6-0.3
Se content in liver1.31.64.9-2.2-1.1-0.7-0.7-1.2-0.71.70.9
Sr content in liver2.72.36.30.0-1.8-1.31.3-2.52.3-0.0-0.9
Zn content in liver0.50.62.0-1.3-0.00.40.1-0.1-0.41.40.7
Bone: minimum diameter0.50.93.40.1-0.3-0.3-1.80.3-1.40.61.2
Time in familiar zone, hab. session 11.11.03.1-1.10.81.10.90.3-0.31.81.1
Time in novel zone, hab. session 10.40.41.41.2-0.5-0.5-0.9-0.2-0.1-0.60.2
Total zone transitions, hab. session 10.70.93.2-0.10.50.8-0.20.5-1.01.81.4
Total locomotion distance, hab. session 10.50.71.7-1.3-1.1-0.9-0.4-0.7-0.10.8-0.8
Locomotion velocity, hab. session 10.60.83.3-1.8-0.8-0.7-0.2-0.4-0.00.8-1.1
Time in familiar zone, hab. session 23.43.68.9-1.12.43.02.41.70.31.90.6
Time in novel zone, hab. session 22.32.45.61.3-1.9-2.1-2.4-1.2-0.8-1.00.8
Total zone transitions, hab. session 20.60.81.80.7-1.0-0.8-1.3-0.1-0.90.61.3
Total locomotion distance, hab. session 20.91.12.9-0.5-1.5-1.4-1.7-0.7-0.80.30.7
Locomotion velocity, hab. session 21.21.63.8-0.3-2.0-1.9-1.9-1.0-0.6-0.00.3
Novel to familiar place preference ratio0.80.94.52.10.2-0.10.5-0.00.7-1.4-0.2
Novelty place preference0.50.63.51.90.30.10.10.30.2-0.90.4
Time in novel zone, NPP test0.50.53.11.80.40.20.20.30.1-0.60.5
Total zone transitions, NPP test0.10.10.4-0.1-0.3-0.2-0.3-0.0-0.50.60.2
Total locomotion distance, NPP test0.40.61.4-0.7-1.2-1.2-0.8-0.6-0.2-0.1-0.7
Locomotion velocity, NPP test0.60.92.3-0.1-1.4-1.5-0.9-0.80.1-0.7-0.9
Intraocular pressure0.50.72.10.1-0.50.0-0.8-0.5-0.71.31.4
Delta distance traveled before/after self-admin0.50.52.2-0.90.0-0.40.4-0.30.5-0.9-1.5
Delta ambulatory time before/after self-admin0.20.31.0-1.0-0.2-0.30.0-0.30.3-0.3-1.0
Parametrial fat weight1.02.49.43.1-0.8-1.1-1.8-0.2-0.1-1.71.5
Pavlov. Cond. lever latency1.11.34.01.70.60.62.0-0.51.4-0.8-0.6
Pavlov. Cond. magazine entry latency1.51.96.4-1.60.0-0.2-2.50.8-2.10.71.1
Pavlov. Cond. change in total contacts3.13.211.7-0.5-2.3-2.4-3.4-0.6-1.1-0.51.1
Pavlov. Cond. index score1.72.15.8-2.2-0.2-0.3-2.40.8-2.01.00.7
Pavlov. Cond. latency score1.62.06.0-1.9-0.2-0.3-2.50.8-2.00.90.9
Pavlov. Cond. lever contacts1.51.85.7-1.7-0.5-0.5-2.40.9-1.90.90.8
Pavlov. Cond. magazine entry number1.21.54.61.6-0.30.12.1-1.11.8-0.4-0.8
Pavlov. Cond. intertrial magazine entries0.81.02.8-1.7-1.0-0.50.9-1.21.00.4-0.8
Pavlov. Cond. lever-magazine prob. diff.2.12.66.5-2.5-0.1-0.2-2.51.0-2.21.20.7
Pavlov. Cond. response bias1.21.54.9-2.0-0.5-0.9-2.20.5-1.40.20.2
Pavlov. Cond. lever latency1.62.25.0-1.3-1.3-1.11.5-2.12.2-0.4-1.0
Pavlov. Cond. magazine entry latency0.10.10.40.6-0.2-0.3-0.50.0-0.5-0.20.1
Pavlov. Cond. change in total contacts0.91.44.21.10.10.5-1.31.0-1.40.92.0
Pavlov. Cond. index score0.81.12.90.80.50.5-1.41.2-1.70.71.0
Pavlov. Cond. latency score0.81.12.90.50.50.5-1.41.2-1.70.81.1
Pavlov. Cond. lever contacts1.62.24.71.51.41.1-1.32.2-2.20.30.9
Pavlov. Cond. magazine entry number0.60.71.2-0.4-0.8-1.00.2-1.11.1-0.9-1.1
Pavlov. Cond. intertrial magazine entries0.20.42.3-1.5-0.1-0.00.4-0.20.30.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.91.23.20.40.50.6-1.41.3-1.80.91.1
Pavlov. Cond. response bias1.01.33.11.41.00.8-1.01.8-1.6-0.00.5
Time in closed arm before self-admin0.70.92.5-1.0-0.0-0.31.6-0.71.2-0.6-1.1
Time in closed arm after self-admin1.71.94.8-1.51.81.22.21.10.4-0.4-1.3
Time in open arm before self-admin1.11.22.1-0.9-0.00.5-1.40.9-1.31.41.5
Time in open arm after self-admin2.02.25.92.3-0.6-0.3-2.40.5-1.40.42.0
Bone: periosteal estimation0.92.04.61.2-2.0-2.2-1.7-1.20.2-1.2-0.1
Bone: periosteal perimeter1.32.25.70.7-2.4-2.4-1.5-1.70.5-0.90.0
Bone: post-yield work0.10.10.4-0.2-0.3-0.20.2-0.60.40.1-0.1
Progressive ratio test 1 active lever presses0.20.20.8-0.20.0-0.20.7-0.40.2-0.1-0.9
Progressive ratio test 1 breakpoint0.20.20.9-0.10.0-0.20.7-0.50.3-0.3-1.0
Progressive ratio test 1 inactive lever presses0.20.31.30.4-0.8-0.7-0.4-1.1-0.00.00.3
Progressive ratio test 2 active lever presses0.80.93.11.8-0.9-0.5-0.5-1.2-0.30.41.0
Progressive ratio test 2 breakpoint0.80.93.51.9-0.9-0.5-0.5-1.3-0.20.30.9
Progressive ratio test 2 inactive lever presses0.71.25.42.3-0.4-0.2-0.8-0.2-0.5-0.01.7
Incentive Sensitization - Responses2.02.85.02.2-1.8-1.3-2.0-1.8-0.90.41.9
Incentive Sensitization - Breakpoint2.12.85.32.3-1.8-1.2-2.0-1.9-0.80.51.9
Sum of active levers in priming session hrs 5-62.01.84.41.0-1.0-1.11.0-0.91.7-1.6-2.1
Progressive ratio0.71.13.41.5-0.2-0.7-1.00.2-0.2-1.8-1.2
Food seeking constrained by brief footshock0.91.12.8-0.4-1.6-1.7-0.4-1.40.6-0.7-0.6
Seeking ratio, punishment vs. effort0.60.82.0-1.4-0.9-0.40.3-0.90.31.31.0
Retroperitoneal fat weight0.52.29.13.0-1.1-1.2-1.5-0.50.2-1.31.4
Reaction time number correct0.20.31.41.20.40.20.50.50.0-0.70.1
Reaction time mean minus median0.30.72.2-0.41.10.60.50.60.2-1.2-1.5
Reaction time mean minus median AUC0.41.13.4-0.31.10.61.30.60.6-1.2-1.9
Reaction time num false alarms0.60.92.00.5-1.4-1.30.1-1.21.0-0.70.3
Reaction time num false alarms AUC0.91.43.90.4-2.0-1.7-0.6-1.70.5-0.40.6
Reaction time trials correct on left0.20.31.41.20.40.20.50.50.0-0.70.1
Reaction time trials on left0.20.31.21.10.40.30.60.50.1-0.70.1
Reaction time mean1.42.26.1-0.31.20.92.20.21.6-1.3-2.5
Reaction time mean AUC1.42.25.8-0.41.41.02.30.41.4-1.1-2.4
Median of all reaction times1.62.26.1-0.11.41.12.50.41.6-1.0-2.2
Reaction time omissions0.20.30.7-0.80.80.80.50.60.10.1-0.3
Reaction time false alarm rate0.91.33.6-0.4-1.9-1.6-0.5-1.80.7-0.00.2
Reaction time premature initiation rate1.92.63.8-1.51.91.90.21.9-1.51.91.3
Reaction time premature initiations1.01.73.0-0.71.71.60.41.7-1.21.31.2
Std. dev. reaction times0.61.03.30.30.60.20.60.21.0-1.8-1.7
Reaction time trials completed0.20.31.21.10.40.30.60.50.1-0.70.1
Reaction time trials AUC0.20.41.51.20.30.10.70.50.3-0.8-0.1
Run reversals in cocaine runway, females0.20.20.7-0.80.00.00.8-0.50.40.3-0.5
Run reversals in cocaine runway, males0.10.10.3-0.20.50.60.30.5-0.30.50.0
Latency to leave start box in cocaine runway0.60.72.7-0.3-0.6-0.40.9-1.61.0-0.0-0.6
Latency to leave start box in cocaine runway, F1.51.74.5-1.4-1.2-0.41.6-2.11.41.2-0.5
Latency to leave start box in cocaine runway, M0.80.72.81.70.7-0.0-0.50.3-0.2-1.50.1
Std. dev. time between licks in bursts0.20.31.0-0.10.1-0.01.0-0.20.7-0.2-0.7
Total sessions with >9 infusions1.11.32.2-1.01.41.4-0.01.3-1.51.20.5
Short access day 1 total inactive lever presses0.50.72.50.7-1.0-0.7-1.6-0.5-0.8-0.10.4
Short access day 10 total inactive lever presses0.51.22.50.10.71.0-1.40.7-1.60.91.4
Short access day 1 total infusions2.22.95.8-0.71.41.6-1.12.0-2.41.72.1
Short access day 10 total infusions0.81.12.7-1.50.40.6-0.3-0.1-1.31.71.2
Short access total infusions0.40.51.6-0.70.30.3-0.70.3-1.20.90.7
Short access day 1 locomotion0.40.51.0-0.11.00.90.11.0-0.90.50.6
Short access day 10 total locomotion1.42.65.0-0.72.02.10.22.2-1.81.70.8
Short access total locomotion2.83.35.5-0.62.12.30.02.3-2.12.21.4
One hour access (0.3 mA shock)0.20.31.31.1-0.2-0.20.4-0.50.4-0.20.2
Compulsive drug intake1.31.53.5-1.90.60.71.80.91.4-0.0-1.3
One hour access (shock baseline)0.81.34.72.2-0.7-0.9-1.3-1.0-0.8-0.60.7
Social response proportion0.40.51.80.6-0.10.10.7-0.81.3-0.5-0.5
Social responses0.40.51.61.3-0.4-0.20.1-1.10.6-0.20.6
Social time0.50.61.60.50.91.31.30.20.60.6-0.1
Soleus weight0.92.77.1-0.4-2.7-2.3-2.2-2.00.1-0.40.4
Bone: stiffness0.20.40.70.60.80.50.80.50.5-0.6-0.1
Tibialis anterior weight1.13.87.91.1-2.8-2.8-1.9-2.50.9-1.70.4
Time to tail flick, vehicle, before self-admin0.10.10.60.20.1-0.20.10.50.0-0.8-0.3
Time to tail flick, vehicle, after self-admin0.10.10.4-0.10.1-0.20.4-0.50.3-0.4-0.6
Time to tail flick, test, before self-admin0.60.62.7-1.60.1-0.20.50.20.2-0.9-0.8
Time to tail flick, test, after self-admin1.01.02.60.5-1.6-1.6-0.6-0.70.8-1.1-0.4
Delta time to tail flick, vehicle, before/after SA0.50.51.7-1.30.20.40.8-0.50.40.9-0.2
Delta time to tail flick, test, before/after SA1.11.16.42.5-0.8-0.7-0.9-0.20.2-0.20.7
Tibia length0.41.01.8-1.3-1.3-1.2-1.2-0.8-0.60.4-0.6
Ambulatory time before self-admin0.30.42.00.90.20.41.4-0.20.7-0.0-0.2
Ambulatory time after self-admin0.50.51.9-0.50.30.21.4-0.31.0-0.3-1.0
Bone: tissue strength0.40.41.00.50.91.00.10.4-0.20.51.0
Total heroin consumption0.10.10.3-0.3-0.0-0.1-0.00.30.1-0.4-0.6
Bone: trabecular number0.50.82.7-0.50.60.51.60.21.0-0.1-1.3
Bone: trabecular spacing1.62.14.11.3-1.5-1.8-0.9-2.00.8-2.0-0.0
Bone: trabecular thickness1.41.84.0-2.01.01.31.71.00.11.7-0.8
Bone: trabecular tissue density0.50.71.70.51.31.01.10.90.3-0.4-0.2
Water consumed over 24 hours0.20.20.9-0.90.00.40.1-0.20.10.90.1
Number of responses in last shaping day0.60.72.5-0.61.20.91.60.40.30.3-0.4