Hub : Genes

Adcy1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Adcy1 0.05 0.03 2.6e-03 -0 0.01 0.01 0 5.8e-01 5.4e-03 1.8e-03 2.4e-01
2 Liver intron excision ratio chr14_86231976_86234154 0.05 0.03 1.3e-04 0.01 0.03 0.02 0.02 1.4e-02 2.5e-04 2.3e-03 1.5e-03
3 Brain gene expression Adcy1 0.09 0.05 1.7e-06 0.04 0.06 0.04 0.05 1.1e-04 2.7e-06 7.9e-05 3.4e-05
4 Liver gene expression Adcy1 0.07 0.04 1.2e-04 0.01 0.03 0.02 0.02 2.2e-02 6.8e-04 1.9e-03 9.3e-04
5 IC gene expression Adcy1 0.07 0.04 5.5e-04 0.1 0.07 0.08 0.08 7.7e-05 8.7e-04 2.6e-04 3.6e-04
6 Liver mRNA stability Adcy1 0.2 0.06 0.0e+00 0.19 0.18 0.18 0.19 2.1e-20 7.0e-20 6.7e-20 2.0e-20
7 Adipose gene expression Adcy1 0.36 0.09 0.0e+00 0.15 0.23 0.21 0.19 2.3e-16 1.1e-24 4.4e-23 2.7e-20
8 Brain mRNA stability Adcy1 0.07 0.03 2.3e-06 0.04 0.06 0.05 0.05 1.7e-04 4.4e-06 2.1e-05 2.1e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.91.74.90.80.70.42.2-0.31.7-0.6-2.0
Area under the delay curve2.64.08.4-0.2-2.7-2.9-0.42.22.0-2.0-1.6
BMI with tail0.10.51.4-0.1-0.8-1.1-0.70.50.2-1.2-0.2
BMI without tail0.20.92.3-0.6-1.1-0.9-1.50.6-0.7-0.11.2
Body weight1.67.016.4-1.4-3.9-4.0-2.32.71.3-2.9-0.5
Weight adjusted by age0.20.52.7-0.6-0.4-0.1-0.00.2-0.20.71.7
Bone surface0.20.30.80.4-0.1-0.30.90.10.9-0.4-0.8
Bone volume0.40.82.20.1-0.0-0.41.40.31.3-0.8-1.5
Breakpoint value in progressive ratio session0.61.12.3-0.0-0.9-1.00.70.71.5-1.4-1.5
Number of licking bursts1.13.28.30.9-1.9-1.90.92.92.2-1.0-1.6
Context. condit. distance diff. score0.60.71.80.31.31.00.7-1.30.2-0.4-0.8
Locomotion velocity, session 10.60.72.2-0.70.60.6-0.8-1.5-1.00.30.8
Locomotion distance, session 10.30.41.61.3-0.10.10.5-0.2-0.00.9-0.6
Locomotion velocity, session 20.91.13.60.71.20.80.9-1.9-0.2-0.0-1.1
Locomotion distance, session 21.31.83.30.61.41.50.0-1.8-1.71.80.9
Locomotion velocity, session 30.60.72.3-0.5-0.1-0.7-1.5-0.9-1.0-1.0-0.2
Locomotion distance, session 32.52.85.2-2.2-1.6-2.2-2.20.4-0.2-2.30.4
Stereotopy head waving bouts, day 31.72.14.32.11.61.71.9-1.40.31.0-0.8
Stereotopy head waving duration, day 32.42.95.81.62.32.41.7-2.1-0.31.4-0.4
Locomotion velocity, session 70.50.61.5-1.0-0.7-0.7-1.2-0.5-0.7-0.10.7
Locomotion distance, session 70.30.41.8-1.3-0.1-0.0-0.4-0.7-0.40.20.5
Stereotopy head waving bouts, day 70.20.31.10.00.60.61.0-0.20.50.00.1
Stereotopy head waving duration, day 70.20.30.90.60.60.70.9-0.10.30.50.2
Locomotion velocity, session 81.11.32.71.61.61.31.5-0.90.30.6-0.5
Locomotion distance, session 82.43.48.10.92.62.5-0.1-2.9-1.91.40.5
Degree of sensitization distance3.63.89.21.02.43.02.0-1.7-0.52.70.5
Degree of sensitization stereotypy0.10.20.6-0.8-0.00.10.10.20.2-0.10.7
Conditioned locomotion0.91.15.51.3-0.4-0.70.40.70.4-0.3-2.4
Cocaine response after cond. corrected1.32.05.00.6-1.4-1.31.11.62.2-1.2-1.3
Cocaine response after cond. not corrected1.21.73.60.4-1.7-1.40.71.91.8-0.7-0.7
Cocaine response before conditioning0.60.82.1-0.00.10.4-0.8-0.3-1.31.41.2
Saline control response0.50.71.51.20.10.3-1.1-0.6-1.20.80.4
Bone: connectivity density0.71.22.81.41.11.21.7-0.80.50.9-0.5
Bone: cortical apparent density0.10.10.5-0.1-0.10.20.10.10.10.40.7
Bone: cortical area1.42.35.6-0.5-2.3-2.4-1.41.90.6-1.10.1
Bone: cortical porosity0.40.41.3-0.3-0.3-0.8-0.60.70.2-1.1-0.5
Bone: cortical porosity0.60.61.7-0.4-0.6-1.0-1.30.8-0.3-1.0-0.2
Bone: cortical thickness1.11.94.90.4-2.2-2.2-1.41.80.3-0.60.1
Bone: cortical thickness0.50.62.11.5-0.7-0.4-0.60.1-0.61.0-0.3
Bone: cortical tissue density0.10.10.5-0.2-0.10.20.10.10.10.40.7
Condit. Reinf. active minus inactive responses0.20.21.20.1-0.4-0.20.4-0.21.1-0.4-0.0
Condit. Reinf. active-inactive response ratio1.01.12.7-1.00.60.31.0-0.81.5-1.6-0.9
Condit. Reinf. active responses0.10.20.60.7-0.4-0.1-0.2-0.40.30.40.5
Condit. Reinf. inactive responses0.81.13.31.5-0.9-0.4-0.60.4-0.81.81.1
Incentive salience index mean0.60.72.10.7-1.4-1.3-0.80.40.7-0.3-0.1
Condit. Reinf. lever presses1.62.47.11.2-2.2-2.1-2.70.7-0.80.20.3
Condit. Reinf. active minus inactive responses0.30.51.10.20.20.5-0.6-0.6-0.71.01.0
Condit. Reinf. active-inactive response ratio0.30.40.8-0.9-0.8-0.8-0.80.50.0-0.40.5
Condit. Reinf. active responses1.01.42.90.71.01.4-0.2-1.4-1.11.71.2
Condit. Reinf. inactive responses1.62.44.51.41.82.10.6-1.9-1.11.90.7
Condit. Reinf. lever presses0.81.13.0-0.3-0.4-0.1-1.6-0.3-1.71.31.2
Condit. Reinf. lever reinforcers received0.71.02.60.70.60.9-0.4-1.1-1.01.61.2
Conditioned reinforcement - actives0.41.59.5-3.10.60.6-0.1-0.4-0.7-0.21.3
Conditioned reinforcement - inactives0.20.61.8-0.5-0.7-0.7-1.30.5-0.7-0.50.6
Conditioned locomotion1.52.214.1-3.80.40.7-0.3-0.5-0.70.31.5
Patch foraging indifference point 0 sec1.23.36.5-2.1-2.3-2.00.22.62.0-1.4-0.2
Patch foraging indifference point AUC0.20.51.30.1-0.1-0.0-1.1-0.4-1.10.61.1
Delay disc. indifference point, 0s delay2.83.27.5-0.3-2.0-2.01.02.72.2-1.3-1.6
Delay disc. indifference point, 16s delay2.12.98.1-0.9-1.6-2.0-0.31.01.8-2.8-2.0
Delay disc. indifference point, 2s delay4.65.19.21.1-2.9-3.00.12.92.3-1.7-2.3
Delay disc. indifference point, 24s delay0.71.12.20.0-1.4-1.5-0.31.11.1-1.3-0.3
Delay disc. indifference point, 4s delay1.81.95.70.1-2.4-1.9-0.22.01.1-0.0-0.2
Delay disc. indifference point, 8s delay0.81.33.7-0.3-1.6-1.9-0.90.80.8-1.3-0.6
Indifference point function ln k0.10.41.2-0.2-0.3-0.20.70.51.1-0.5-0.7
Indifference point function log k0.10.41.2-0.2-0.3-0.20.70.51.1-0.5-0.7
Patch foraging total patch changes 0 sec1.13.26.1-2.0-2.4-2.1-0.12.51.8-1.4-0.1
Patch foraging total patch changes 12 sec0.60.91.5-0.9-1.2-1.10.31.21.1-0.9-0.0
Patch foraging total patch changes 18 sec1.02.56.0-2.5-2.1-1.8-1.21.60.6-0.90.9
Patch foraging total patch changes 24 sec0.41.44.0-0.31.11.50.7-0.5-0.51.62.0
Patch foraging total patch changes 6 sec0.91.53.6-1.9-1.7-1.3-0.31.50.9-0.50.7
Patch foraging time to switch 0 sec0.20.82.50.51.11.01.6-0.40.50.1-0.9
Patch foraging water rate 0 sec0.20.81.6-1.3-1.3-0.9-0.90.70.2-0.00.8
Patch foraging water rate 12 sec0.21.03.1-1.4-0.5-0.1-1.2-0.5-0.60.51.8
Patch foraging water rate 18 sec0.51.12.8-0.5-0.80.0-1.30.4-1.01.61.7
Patch foraging water rate 24 sec0.71.02.6-1.60.20.5-1.2-1.0-0.90.31.2
Patch foraging water rate 6 sec0.30.51.4-0.8-0.30.1-1.0-0.7-0.50.51.2
Seeking ratio, delayed vs. immediate footshock0.30.51.6-0.70.3-0.0-1.3-0.6-0.8-0.50.4
Distance traveled before self-admin0.20.41.1-0.40.70.91.1-0.2-0.10.70.1
Distance traveled after self-admin0.20.41.20.40.1-0.11.00.60.7-0.4-1.1
Extensor digitorum longus weight1.76.813.1-2.5-3.6-3.5-2.93.10.5-1.61.5
Bone: elastic displacement0.50.72.11.10.1-0.0-1.4-0.2-1.50.3-0.1
Bone: elastic work0.60.71.40.8-1.2-1.0-1.11.0-0.30.3-0.5
Bone: endosteal estimation0.40.92.0-1.4-1.1-1.3-1.20.4-0.0-0.9-0.4
Bone: endosteal perimeter0.41.13.0-0.5-1.7-1.7-1.00.90.4-0.7-0.4
Epididymis fat weight0.83.88.1-2.8-2.2-2.5-1.71.50.6-2.4-0.2
Delta time in closed arm before/after self-admin4.94.69.01.62.82.80.4-3.0-2.02.00.8
Delta time in open arm before/after self-admin2.32.75.1-2.2-2.1-2.2-0.92.10.8-1.2-0.1
Diff in mean of infusions in LGA sessions0.50.82.2-0.0-0.4-0.80.60.61.1-1.5-1.3
Delay discount exponential model param2.73.68.10.22.72.80.5-2.2-1.81.81.3
Extinction: sum of active levers before priming0.81.24.1-1.2-0.5-0.8-2.0-0.3-1.3-1.00.7
Active lever presses in extinction session 60.40.41.00.6-1.0-0.9-1.00.2-0.3-0.2-0.4
Bone: final force0.10.10.5-0.40.0-0.10.30.20.7-0.50.2
Bone: final moment0.20.30.8-0.5-0.2-0.40.20.60.9-0.70.1
Food consumed during 24 hour testing period0.30.61.7-0.7-0.9-0.9-1.30.20.1-0.40.6
Glucose3.04.832.0-5.7-0.4-0.4-0.4-0.10.8-1.61.5
Heart weight0.91.57.6-2.8-0.5-0.4-1.4-0.2-0.6-0.51.2
Delay discount hyperbolic model param3.03.98.90.12.93.00.6-2.2-1.91.91.4
Intermittent access intake day 1-15 change0.31.66.5-2.5-0.5-0.6-1.41.0-0.7-0.61.4
Intermittent access intake escalation0.31.76.8-2.6-0.8-0.9-1.51.1-0.6-0.81.1
Intermittent access intake escalation 20.81.43.9-1.2-0.6-0.5-2.00.8-1.20.11.7
Intermitt. access day 1 inactive lever presses0.00.30.70.80.70.3-0.1-0.3-0.80.10.7
Intermitt. access day 15 inactive lever presses0.21.25.8-2.4-0.6-0.9-0.90.50.1-1.00.7
Intermitt. access escalation Index0.41.23.7-0.10.40.11.80.31.9-1.2-1.1
Intermittent access day 1 total infusions0.20.52.61.6-0.2-0.20.50.50.20.2-0.8
Intermittent access day 15 total infusions0.40.92.3-1.5-1.0-0.9-0.81.4-0.2-0.40.6
Intermittent access terminal intake (last 3 days)0.61.02.1-1.2-0.7-0.4-1.40.9-0.80.41.5
Intermittent access total infusions0.50.61.0-1.0-0.9-0.8-1.00.9-0.5-0.20.4
Intermittent access day 1 locomotion0.61.12.10.31.31.50.5-1.4-0.81.20.6
Intermittent access day 15 total locomotion0.31.05.0-2.2-0.40.1-0.9-0.2-0.80.51.1
Intermittent access total locomotion0.50.61.7-1.3-0.5-0.1-0.8-0.0-0.80.71.1
Intermittent access standard deviation0.84.312.2-0.11.51.6-2.3-1.7-3.51.42.8
Left kidney weight0.11.12.9-0.4-1.0-0.4-1.50.8-0.70.91.7
Right kidney weight0.10.92.4-0.1-1.4-1.1-1.51.1-0.4-0.10.9
Cocaine induced anxiety0.30.92.1-0.7-1.4-1.3-0.81.50.3-0.3-0.5
Post-drug Anxiety1.21.43.4-0.4-1.6-1.5-0.11.81.1-0.7-0.9
Baseline Anxiety0.10.20.70.1-0.3-0.50.50.30.7-0.9-0.1
Tail length0.95.012.0-2.1-3.5-3.1-1.62.81.1-1.4-0.0
Length with tail1.56.516.0-2.2-4.0-3.6-2.03.21.2-1.6-0.1
Length without tail0.63.05.6-1.0-1.7-1.80.91.62.4-2.1-1.7
Times rat made contact with spout0.60.71.4-0.71.11.1-0.5-1.2-0.60.11.0
Lifetime Intake0.40.41.1-0.6-0.8-0.8-1.00.6-0.6-0.20.3
Liver weight, left0.20.41.10.80.1-0.1-0.9-0.5-1.1-0.3-0.4
Liver weight, right1.12.04.60.40.70.6-1.9-1.2-2.11.12.0
Locomotor activity0.60.92.4-0.7-1.2-1.3-1.60.2-0.1-1.10.1
Locomotor testing distance1.02.55.3-1.3-2.2-2.3-2.11.0-0.1-1.5-0.1
Locomotor testing rearing0.31.22.3-1.4-1.5-1.5-0.80.80.4-1.30.3
Locomotion in novel chamber0.70.96.42.5-0.1-0.2-0.10.5-0.40.8-0.1
Locomotion in novel chamber post-restriction0.30.82.01.01.41.20.4-1.1-0.40.2-0.6
Fecal boli incidents, locomotor time 10.20.51.40.10.70.7-0.4-0.4-1.21.00.6
Change in fecal boli incidents, locomotor task0.40.42.3-1.50.1-0.20.0-0.00.5-0.90.3
Time >=10cm from walls, locomotor time 11.82.39.40.61.51.63.1-0.51.20.5-1.3
Bouts of movement, locomotor time 10.60.81.7-0.90.30.51.20.70.51.11.3
Total resting periods, locomotor time 10.80.93.4-1.30.40.60.20.3-0.31.01.8
Rest time, locomotor task time 10.40.61.5-1.10.90.8-0.0-0.8-0.60.21.2
Distance moved, locomotor task time 10.10.20.60.4-0.7-0.6-0.8-0.0-0.40.2-0.2
Vertical activity count, locomotor time 10.10.93.60.6-0.6-0.70.50.11.1-0.9-1.9
Time >=10cm from walls, locomotor time 20.51.53.20.81.51.81.6-1.0-0.11.3-0.5
Bouts of movement, locomotor time 20.31.02.1-0.9-1.1-1.1-0.61.40.20.11.4
Total resting periods, locomotor time 20.20.92.3-1.0-1.0-0.9-0.31.40.30.31.5
Rest time, locomotor task time 20.40.81.2-0.81.11.00.3-1.1-0.70.61.0
Distance moved, locomotor task time 20.20.31.41.20.10.1-0.40.1-0.60.7-0.0
Vertical activity count, locomotor time 20.41.03.61.8-0.3-0.50.40.40.8-0.4-1.9
Light reinforcement 10.10.71.4-0.9-0.7-0.6-1.20.1-0.90.41.1
Light reinforcement 20.81.88.71.3-0.60.2-0.90.1-1.22.91.2
Bone: marrow area0.30.91.8-1.4-1.0-1.3-1.00.40.1-1.0-0.6
Bone: maximum diameter1.63.26.2-2.2-2.5-2.4-1.42.00.9-1.20.8
Bone: maximum force0.10.20.4-0.1-0.5-0.6-0.30.60.3-0.40.1
Bone: maximum moment0.20.41.0-0.2-0.7-0.8-0.31.00.5-0.50.0
Mean time between licks in bursts0.10.30.90.9-0.0-0.10.70.21.00.1-0.5
Mean num. licks in bursts1.43.79.7-1.02.22.2-1.0-3.1-2.10.81.7
Cd content in liver0.70.72.5-1.2-0.6-0.8-0.60.80.3-1.6-0.0
Co content in liver2.12.56.1-1.1-2.1-2.5-1.71.40.2-1.7-0.7
Cu content in liver0.60.72.70.90.80.81.7-0.30.8-0.1-0.1
Fe content in liver0.30.42.00.50.60.20.4-0.5-0.2-0.1-1.4
K content in liver1.71.75.22.3-0.8-1.01.21.31.2-0.4-1.3
Mg content in liver0.50.51.81.3-0.4-0.50.70.90.5-0.3-0.3
Mn content in liver0.20.21.21.1-0.2-0.3-0.10.2-0.50.40.1
Na content in liver1.41.64.1-0.2-1.7-2.0-0.21.81.0-1.1-0.5
Rb content in liver0.70.82.5-0.9-0.1-0.31.10.01.3-1.6-0.3
Se content in liver1.31.64.92.2-1.1-0.7-0.71.2-0.71.70.9
Sr content in liver2.72.36.3-0.0-1.8-1.31.32.52.3-0.0-0.9
Zn content in liver0.50.62.01.3-0.00.40.10.1-0.41.40.7
Bone: minimum diameter0.50.93.4-0.1-0.3-0.3-1.8-0.3-1.40.61.2
Time in familiar zone, hab. session 11.01.03.11.10.81.10.9-0.3-0.31.81.1
Time in novel zone, hab. session 10.40.41.4-1.2-0.5-0.5-0.90.2-0.1-0.60.2
Total zone transitions, hab. session 10.70.93.20.10.50.8-0.2-0.5-1.01.81.4
Total locomotion distance, hab. session 10.50.71.71.3-1.1-0.9-0.40.7-0.10.8-0.8
Locomotion velocity, hab. session 10.60.83.31.8-0.8-0.7-0.20.4-0.00.8-1.1
Time in familiar zone, hab. session 23.23.68.91.12.43.02.4-1.70.31.90.6
Time in novel zone, hab. session 22.22.45.6-1.3-1.9-2.1-2.41.2-0.8-1.00.8
Total zone transitions, hab. session 20.60.81.8-0.7-1.0-0.8-1.30.1-0.90.61.3
Total locomotion distance, hab. session 20.91.12.90.5-1.5-1.4-1.70.7-0.80.30.7
Locomotion velocity, hab. session 21.21.63.80.3-2.0-1.9-1.91.0-0.6-0.00.3
Novel to familiar place preference ratio0.70.94.5-2.10.2-0.10.50.00.7-1.4-0.2
Novelty place preference0.50.63.5-1.90.30.10.1-0.30.2-0.90.4
Time in novel zone, NPP test0.40.53.1-1.80.40.20.2-0.30.1-0.60.5
Total zone transitions, NPP test0.10.10.40.1-0.3-0.2-0.30.0-0.50.60.2
Total locomotion distance, NPP test0.40.61.40.7-1.2-1.2-0.80.6-0.2-0.1-0.7
Locomotion velocity, NPP test0.60.92.30.1-1.4-1.5-0.90.80.1-0.7-0.9
Intraocular pressure0.40.72.1-0.1-0.50.0-0.80.5-0.71.31.4
Delta distance traveled before/after self-admin0.50.52.20.90.0-0.40.40.30.5-0.9-1.5
Delta ambulatory time before/after self-admin0.20.31.01.0-0.2-0.30.00.30.3-0.3-1.0
Parametrial fat weight1.02.49.4-3.1-0.8-1.1-1.80.2-0.1-1.71.5
Pavlov. Cond. lever latency1.11.34.0-1.70.60.62.00.51.4-0.8-0.6
Pavlov. Cond. magazine entry latency1.51.96.41.60.0-0.2-2.5-0.8-2.10.71.1
Pavlov. Cond. change in total contacts3.03.211.70.5-2.3-2.4-3.40.6-1.1-0.51.1
Pavlov. Cond. index score1.72.15.82.2-0.2-0.3-2.4-0.8-2.01.00.7
Pavlov. Cond. latency score1.62.06.01.9-0.2-0.3-2.5-0.8-2.00.90.9
Pavlov. Cond. lever contacts1.51.85.71.7-0.5-0.5-2.4-0.9-1.90.90.8
Pavlov. Cond. magazine entry number1.21.54.6-1.6-0.30.12.11.11.8-0.4-0.8
Pavlov. Cond. intertrial magazine entries0.81.02.81.7-1.0-0.50.91.21.00.4-0.8
Pavlov. Cond. lever-magazine prob. diff.2.12.66.52.5-0.1-0.2-2.5-1.0-2.21.20.7
Pavlov. Cond. response bias1.21.54.92.0-0.5-0.9-2.2-0.5-1.40.20.2
Pavlov. Cond. lever latency1.62.25.01.3-1.3-1.11.52.12.2-0.4-1.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.6-0.2-0.3-0.5-0.0-0.5-0.20.1
Pavlov. Cond. change in total contacts0.61.44.2-1.10.10.5-1.3-1.0-1.40.92.0
Pavlov. Cond. index score0.71.12.9-0.80.50.5-1.4-1.2-1.70.71.0
Pavlov. Cond. latency score0.71.12.9-0.50.50.5-1.4-1.2-1.70.81.1
Pavlov. Cond. lever contacts1.52.24.7-1.51.41.1-1.3-2.2-2.20.30.9
Pavlov. Cond. magazine entry number0.60.71.20.4-0.8-1.00.21.11.1-0.9-1.1
Pavlov. Cond. intertrial magazine entries0.20.42.31.5-0.1-0.00.40.20.30.3-0.5
Pavlov. Cond. lever-magazine prob. diff.0.81.23.2-0.40.50.6-1.4-1.3-1.80.91.1
Pavlov. Cond. response bias1.01.33.1-1.41.00.8-1.0-1.8-1.6-0.00.5
Time in closed arm before self-admin0.50.92.51.0-0.0-0.31.60.71.2-0.6-1.1
Time in closed arm after self-admin1.61.94.81.51.81.22.2-1.10.4-0.4-1.3
Time in open arm before self-admin1.01.22.10.9-0.00.5-1.4-0.9-1.31.41.5
Time in open arm after self-admin2.02.25.9-2.3-0.6-0.3-2.4-0.5-1.40.42.0
Bone: periosteal estimation0.82.04.6-1.2-2.0-2.2-1.71.20.2-1.2-0.1
Bone: periosteal perimeter1.12.25.7-0.7-2.4-2.4-1.51.70.5-0.90.0
Bone: post-yield work0.10.10.40.2-0.3-0.20.20.60.40.1-0.1
Progressive ratio test 1 active lever presses0.10.20.80.20.0-0.20.70.40.2-0.1-0.9
Progressive ratio test 1 breakpoint0.10.20.90.10.0-0.20.70.50.3-0.3-1.0
Progressive ratio test 1 inactive lever presses0.10.31.3-0.4-0.8-0.7-0.41.1-0.00.00.3
Progressive ratio test 2 active lever presses0.60.93.1-1.8-0.9-0.5-0.51.2-0.30.41.0
Progressive ratio test 2 breakpoint0.70.93.5-1.9-0.9-0.5-0.51.3-0.20.30.9
Progressive ratio test 2 inactive lever presses0.41.25.3-2.3-0.4-0.2-0.80.2-0.5-0.01.7
Incentive Sensitization - Responses1.02.85.0-2.2-1.8-1.3-2.01.8-0.90.41.9
Incentive Sensitization - Breakpoint1.22.85.3-2.3-1.8-1.2-2.01.9-0.80.51.9
Sum of active levers in priming session hrs 5-62.01.84.4-1.0-1.0-1.11.00.91.7-1.6-2.1
Progressive ratio0.41.13.4-1.5-0.2-0.7-1.0-0.2-0.2-1.8-1.2
Food seeking constrained by brief footshock0.91.12.80.4-1.6-1.7-0.41.40.6-0.7-0.6
Seeking ratio, punishment vs. effort0.40.82.01.4-0.9-0.40.30.90.31.31.0
Retroperitoneal fat weight0.52.29.1-3.0-1.1-1.2-1.50.50.2-1.31.4
Reaction time number correct0.10.31.4-1.20.40.20.5-0.50.0-0.70.1
Reaction time mean minus median0.10.72.20.41.10.60.5-0.60.2-1.2-1.5
Reaction time mean minus median AUC0.21.13.40.31.10.61.3-0.60.6-1.2-1.9
Reaction time num false alarms0.50.92.0-0.5-1.4-1.30.11.21.0-0.70.3
Reaction time num false alarms AUC0.61.43.9-0.4-2.0-1.7-0.61.70.5-0.40.6
Reaction time trials correct on left0.10.31.4-1.20.40.20.5-0.50.0-0.70.1
Reaction time trials on left0.10.31.2-1.10.40.30.6-0.50.1-0.70.1
Reaction time mean1.02.26.10.31.20.92.2-0.21.6-1.3-2.5
Reaction time mean AUC0.92.25.80.41.41.02.3-0.41.4-1.1-2.4
Median of all reaction times1.42.26.10.11.41.12.5-0.41.6-1.0-2.2
Reaction time omissions0.20.30.70.80.80.80.5-0.60.10.1-0.3
Reaction time false alarm rate0.91.33.60.4-1.9-1.6-0.51.80.7-0.00.2
Reaction time premature initiation rate1.72.63.81.51.91.90.2-1.9-1.51.91.3
Reaction time premature initiations0.61.73.00.71.71.60.4-1.7-1.21.31.2
Std. dev. reaction times0.31.03.3-0.30.60.20.6-0.21.0-1.8-1.7
Reaction time trials completed0.10.31.2-1.10.40.30.6-0.50.1-0.70.1
Reaction time trials AUC0.10.41.5-1.20.30.10.7-0.50.3-0.8-0.1
Run reversals in cocaine runway, females0.20.20.70.80.00.00.80.50.40.3-0.5
Run reversals in cocaine runway, males0.10.10.30.20.50.60.3-0.5-0.30.50.0
Latency to leave start box in cocaine runway0.50.72.70.3-0.6-0.40.91.61.0-0.0-0.6
Latency to leave start box in cocaine runway, F1.41.74.51.4-1.2-0.41.62.11.41.2-0.5
Latency to leave start box in cocaine runway, M0.80.72.8-1.70.7-0.0-0.5-0.3-0.2-1.50.1
Std. dev. time between licks in bursts0.10.31.00.10.1-0.01.00.20.7-0.2-0.7
Total sessions with >9 infusions1.11.32.21.01.41.4-0.0-1.3-1.51.20.5
Short access day 1 total inactive lever presses0.30.72.5-0.7-1.0-0.7-1.60.5-0.8-0.10.4
Short access day 10 total inactive lever presses0.21.22.5-0.10.71.0-1.4-0.7-1.60.91.4
Short access day 1 total infusions1.52.95.80.71.41.6-1.1-2.0-2.41.72.1
Short access day 10 total infusions0.71.12.71.50.40.6-0.30.1-1.31.71.2
Short access total infusions0.40.51.60.70.30.3-0.7-0.3-1.20.90.7
Short access day 1 locomotion0.30.51.00.11.00.90.1-1.0-0.90.50.6
Short access day 10 total locomotion0.62.65.00.72.02.10.2-2.2-1.81.70.8
Short access total locomotion2.23.35.50.62.12.30.0-2.3-2.12.21.4
One hour access (0.3 mA shock)0.20.31.2-1.1-0.2-0.20.40.50.4-0.20.2
Compulsive drug intake1.01.53.51.90.60.71.8-0.91.4-0.0-1.3
One hour access (shock baseline)0.51.34.7-2.2-0.7-0.9-1.31.0-0.8-0.60.7
Social response proportion0.40.51.8-0.6-0.10.10.70.81.3-0.5-0.5
Social responses0.40.51.6-1.3-0.4-0.20.11.10.6-0.20.6
Social time0.40.61.6-0.50.91.31.3-0.20.60.6-0.1
Soleus weight0.92.77.10.4-2.7-2.3-2.22.00.1-0.40.4
Bone: stiffness0.20.40.7-0.60.80.50.8-0.50.5-0.6-0.1
Tibialis anterior weight1.13.87.9-1.1-2.8-2.8-1.92.50.9-1.70.4
Time to tail flick, vehicle, before self-admin0.10.10.6-0.20.1-0.20.1-0.50.0-0.8-0.3
Time to tail flick, vehicle, after self-admin0.10.10.40.10.1-0.20.40.50.3-0.4-0.6
Time to tail flick, test, before self-admin0.50.62.71.60.1-0.20.5-0.20.2-0.9-0.8
Time to tail flick, test, after self-admin1.01.02.6-0.5-1.6-1.6-0.60.70.8-1.1-0.4
Delta time to tail flick, vehicle, before/after SA0.50.51.81.30.20.40.80.50.40.9-0.2
Delta time to tail flick, test, before/after SA0.91.16.4-2.5-0.8-0.7-0.90.20.2-0.20.7
Tibia length0.41.01.81.3-1.3-1.2-1.20.8-0.60.4-0.6
Ambulatory time before self-admin0.10.42.0-0.90.20.41.40.20.7-0.0-0.2
Ambulatory time after self-admin0.30.51.90.50.30.21.40.31.0-0.3-1.0
Bone: tissue strength0.40.41.0-0.50.91.00.1-0.4-0.20.51.0
Total heroin consumption0.10.10.30.3-0.0-0.1-0.0-0.30.1-0.4-0.6
Bone: trabecular number0.40.82.70.50.60.51.6-0.21.0-0.1-1.3
Bone: trabecular spacing1.42.14.1-1.3-1.5-1.8-0.92.00.8-2.0-0.0
Bone: trabecular thickness1.31.84.02.01.01.31.7-1.00.11.7-0.8
Bone: trabecular tissue density0.40.71.7-0.51.31.01.1-0.90.3-0.4-0.2
Water consumed over 24 hours0.10.20.90.90.00.40.10.20.10.90.1
Number of responses in last shaping day0.50.72.50.61.20.91.6-0.40.30.3-0.4