Hub : Genes

Adamts6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Adamts6	0.03	0.03	1.0e-03	0.02	0.02	0.02	0.01	3.3e-03	5.6e-03	2.2e-03	1.8e-02
2	pVTA	gene expression	Adamts6	0.03	0.03	8.0e-03	0.01	-0	0.01	-0	2.2e-02	4.2e-01	3.9e-02	7.2e-01
3	LHb	alternative TSS	XM_017591188.2	0.15	0.13	7.9e-03	0.05	0.01	0.03	0.04	2.5e-02	1.7e-01	6.1e-02	3.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.6	1.0	1.1	-1.0	-0.9	1.1
Area under the delay curve	0.3	0.3	0.5	0.6	0.7	-0.3
BMI with tail	2.1	7.3	8.5	-2.6	-2.6	2.9
BMI without tail	0.4	1.2	1.7	-0.9	-1.1	1.3
Body weight	3.9	17.1	19.3	4.2	4.4	-3.8
Weight adjusted by age	0.0	0.0	0.1	0.2	0.2	-0.2
Bone surface	0.0	0.0	0.0	0.0	0.1	-0.0
Bone volume	0.0	0.0	0.1	-0.2	-0.2	0.2
Breakpoint value in progressive ratio session	2.9	3.5	3.9	-2.0	-1.8	1.8
Number of licking bursts	2.0	3.3	3.7	-1.9	-1.9	1.7
Context. condit. distance diff. score	1.9	2.2	2.4	1.5	1.6	-1.4
Locomotion velocity, session 1	0.3	0.3	0.4	0.6	0.6	-0.5
Locomotion distance, session 1	0.8	1.0	1.1	1.0	1.0	-1.1
Locomotion velocity, session 2	4.2	4.9	5.3	2.3	2.2	-2.1
Locomotion distance, session 2	0.7	1.0	1.2	1.1	1.0	-0.9
Locomotion velocity, session 3	5.1	5.8	6.3	2.4	2.5	-2.3
Locomotion distance, session 3	7.4	8.0	8.5	2.9	2.9	-2.7
Stereotopy head waving bouts, day 3	0.2	0.2	0.4	0.3	0.5	-0.6
Stereotopy head waving duration, day 3	0.0	0.0	0.1	-0.3	-0.1	0.1
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	0.3	-0.2
Locomotion distance, session 7	0.3	0.4	0.5	0.7	0.6	-0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.0	-0.2	0.0	-0.1
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.2	0.4	-0.5
Locomotion velocity, session 8	2.5	3.0	3.1	1.8	1.7	-1.8
Locomotion distance, session 8	4.5	6.6	7.0	2.6	2.6	-2.5
Degree of sensitization distance	3.9	4.0	4.7	-2.0	-2.2	1.8
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.2	-0.1	-0.0
Conditioned locomotion	0.0	0.0	0.0	-0.1	0.0	0.1
Cocaine response after cond. corrected	1.8	2.2	2.3	1.5	1.5	-1.5
Cocaine response after cond. not corrected	2.6	3.0	3.1	1.7	1.7	-1.8
Cocaine response before conditioning	0.3	0.3	0.4	0.6	0.6	-0.5
Saline control response	1.2	1.6	1.7	1.3	1.2	-1.2
Bone: connectivity density	0.0	0.1	0.1	-0.2	-0.3	0.2
Bone: cortical apparent density	0.0	0.0	0.0	0.1	-0.0	-0.1
Bone: cortical area	0.2	0.2	0.3	0.5	0.5	-0.5
Bone: cortical porosity	2.3	2.5	2.7	-1.7	-1.5	1.6
Bone: cortical porosity	2.2	2.4	2.7	-1.7	-1.5	1.5
Bone: cortical thickness	0.1	0.2	0.3	0.3	0.3	-0.6
Bone: cortical thickness	1.1	1.3	1.6	1.2	1.2	-1.0
Bone: cortical tissue density	0.0	0.0	0.0	0.1	0.0	-0.2
Condit. Reinf. active minus inactive responses	1.7	1.9	2.4	-1.5	-1.5	1.1
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.2	-1.5	-1.5	1.1
Condit. Reinf. active responses	0.3	0.3	0.5	-0.6	-0.7	0.3
Condit. Reinf. inactive responses	1.0	1.3	1.3	1.2	1.1	-1.1
Incentive salience index mean	1.2	1.5	1.7	-1.3	-1.3	1.0
Condit. Reinf. lever presses	0.2	0.3	0.3	-0.6	-0.5	0.5
Condit. Reinf. active minus inactive responses	4.4	5.6	6.1	2.3	2.5	-2.3
Condit. Reinf. active-inactive response ratio	2.2	2.6	2.8	1.6	1.7	-1.6
Condit. Reinf. active responses	1.5	2.1	2.1	1.4	1.5	-1.5
Condit. Reinf. inactive responses	0.1	0.1	0.1	0.3	0.3	-0.4
Condit. Reinf. lever presses	2.0	2.7	3.3	1.6	1.5	-1.8
Condit. Reinf. lever reinforcers received	2.0	2.8	2.9	1.6	1.7	-1.7
Conditioned reinforcement - actives	1.8	3.1	3.9	2.0	1.6	-1.7
Conditioned reinforcement - inactives	1.0	1.5	1.9	1.3	0.9	-1.4
Conditioned locomotion	0.7	0.9	1.3	1.1	0.9	-0.9
Patch foraging indifference point 0 sec	3.9	7.2	8.3	2.6	2.6	-2.9
Patch foraging indifference point AUC	0.5	0.7	0.8	-0.9	-0.9	0.8
Delay disc. indifference point, 0s delay	0.3	0.4	0.6	-0.8	-0.5	0.5
Delay disc. indifference point, 16s delay	1.1	1.2	1.7	1.3	1.2	-0.8
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	-0.6	-0.4	0.6
Delay disc. indifference point, 24s delay	1.1	1.2	1.5	1.2	1.1	-1.0
Delay disc. indifference point, 4s delay	0.0	0.0	0.0	-0.2	0.1	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	0.5	0.4	-0.2
Indifference point function ln k	3.0	5.3	5.4	2.3	2.3	-2.3
Indifference point function log k	3.0	5.3	5.4	2.3	2.3	-2.3
Patch foraging total patch changes 0 sec	4.5	8.5	9.6	2.8	2.8	-3.1
Patch foraging total patch changes 12 sec	0.0	0.0	0.0	0.1	0.1	-0.1
Patch foraging total patch changes 18 sec	0.0	0.0	0.0	-0.1	-0.0	-0.2
Patch foraging total patch changes 24 sec	0.7	1.2	1.4	1.0	1.0	-1.2
Patch foraging total patch changes 6 sec	0.9	1.4	1.9	1.1	1.0	-1.4
Patch foraging time to switch 0 sec	4.0	8.3	9.1	-2.8	-2.8	3.0
Patch foraging water rate 0 sec	3.4	7.2	7.7	2.7	2.6	-2.8
Patch foraging water rate 12 sec	3.6	7.5	7.7	2.7	2.8	-2.8
Patch foraging water rate 18 sec	5.5	8.6	9.0	3.0	3.0	-2.8
Patch foraging water rate 24 sec	2.6	3.7	4.3	2.0	2.1	-1.7
Patch foraging water rate 6 sec	13.1	19.1	19.7	4.4	4.4	-4.3
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	1.8	-1.1	-1.1	1.4
Distance traveled before self-admin	0.7	0.9	1.3	0.9	1.1	-0.8
Distance traveled after self-admin	1.3	1.6	2.0	1.3	1.4	-1.1
Extensor digitorum longus weight	4.1	15.9	17.1	-4.0	-3.9	4.1
Bone: elastic displacement	1.8	2.1	2.3	-1.5	-1.5	1.4
Bone: elastic work	0.5	0.6	0.7	-0.8	-0.8	0.8
Bone: endosteal estimation	0.4	0.9	1.0	1.0	1.0	-0.8
Bone: endosteal perimeter	0.0	0.0	0.1	0.2	0.2	-0.2
Epididymis fat weight	0.9	3.2	3.5	1.7	1.8	-1.9
Delta time in closed arm before/after self-admin	3.4	3.2	3.5	-1.7	-1.8	1.9
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.3	0.5
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.0	0.2	0.1
Delay discount exponential model param	0.3	0.3	0.5	-0.6	-0.7	0.3
Extinction: sum of active levers before priming	2.4	2.7	3.3	-1.8	-1.7	1.3
Active lever presses in extinction session 6	3.2	3.2	3.3	-1.8	-1.7	1.8
Bone: final force	0.4	0.7	0.7	0.9	0.8	-0.8
Bone: final moment	0.7	1.1	1.1	1.1	1.0	-1.0
Food consumed during 24 hour testing period	0.8	1.1	1.2	1.0	1.0	-1.1
Glucose	0.3	0.4	0.7	-0.7	-0.9	0.3
Heart weight	0.8	1.3	1.7	1.1	1.0	-1.3
Delay discount hyperbolic model param	0.2	0.3	0.4	-0.5	-0.6	0.3
Intermittent access intake day 1-15 change	0.0	0.0	0.0	-0.1	-0.0	0.1
Intermittent access intake escalation	0.0	0.1	0.1	0.2	0.3	-0.1
Intermittent access intake escalation 2	0.3	0.3	0.6	-0.5	-0.4	0.7
Intermitt. access day 1 inactive lever presses	0.3	1.2	1.7	-1.1	-1.3	0.9
Intermitt. access day 15 inactive lever presses	0.6	1.3	1.6	-1.0	-1.3	1.1
Intermitt. access escalation Index	0.3	0.4	0.8	0.5	0.9	-0.3
Intermittent access day 1 total infusions	1.3	2.2	2.7	1.6	1.3	-1.5
Intermittent access day 15 total infusions	2.0	3.0	3.3	1.8	1.6	-1.8
Intermittent access terminal intake (last 3 days)	1.2	1.6	1.7	1.3	1.2	-1.3
Intermittent access total infusions	3.3	3.9	4.3	2.1	1.8	-2.1
Intermittent access day 1 locomotion	2.4	3.0	3.2	1.8	1.7	-1.8
Intermittent access day 15 total locomotion	1.9	3.5	3.9	1.9	1.7	-2.0
Intermittent access total locomotion	4.5	5.4	5.8	2.4	2.3	-2.3
Intermittent access standard deviation	0.0	0.0	0.1	-0.1	-0.3	0.2
Left kidney weight	2.8	12.8	13.4	3.5	3.6	-3.7
Right kidney weight	2.7	12.1	12.7	3.4	3.5	-3.6
Cocaine induced anxiety	0.7	1.0	1.0	1.0	1.0	-1.0
Post-drug Anxiety	0.5	0.5	0.6	0.8	0.7	-0.7
Baseline Anxiety	0.1	0.1	0.2	-0.4	-0.4	0.4
Tail length	10.4	40.5	41.6	6.4	6.4	-6.3
Length with tail	15.8	68.6	72.2	8.4	8.5	-8.0
Length without tail	11.1	35.7	38.3	5.9	6.2	-5.8
Times rat made contact with spout	0.3	0.4	0.4	-0.7	-0.6	0.5
Lifetime Intake	2.7	3.3	3.7	1.9	1.6	-1.9
Liver weight, left	5.0	8.3	9.2	2.8	2.8	-3.0
Liver weight, right	0.1	0.2	0.4	0.2	0.1	-0.6
Locomotor activity	0.4	0.6	0.7	0.8	0.6	-0.8
Locomotor testing distance	0.1	0.2	0.3	-0.4	-0.6	0.2
Locomotor testing rearing	0.1	0.1	0.2	-0.3	-0.5	0.2
Locomotion in novel chamber	0.7	0.9	1.4	-0.9	-0.8	1.2
Locomotion in novel chamber post-restriction	0.0	0.1	0.1	-0.1	-0.2	0.3
Fecal boli incidents, locomotor time 1	1.0	1.5	2.0	-1.2	-1.4	1.0
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	-0.1	-0.1	0.5
Time >=10cm from walls, locomotor time 1	1.7	1.8	2.2	-1.2	-1.5	1.3
Bouts of movement, locomotor time 1	0.4	0.4	0.5	-0.7	-0.7	0.6
Total resting periods, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	0.1
Rest time, locomotor task time 1	0.7	0.9	0.9	-0.9	-1.0	0.9
Distance moved, locomotor task time 1	0.9	1.4	1.6	1.2	1.3	-1.0
Vertical activity count, locomotor time 1	0.3	0.6	1.2	0.8	1.1	-0.4
Time >=10cm from walls, locomotor time 2	0.7	1.0	1.2	-0.9	-1.1	1.0
Bouts of movement, locomotor time 2	0.1	0.1	0.2	0.5	0.4	0.1
Total resting periods, locomotor time 2	0.1	0.1	0.3	-0.0	-0.1	0.5
Rest time, locomotor task time 2	2.9	3.6	3.8	-1.9	-1.9	1.9
Distance moved, locomotor task time 2	1.4	1.7	2.2	1.4	1.5	-1.0
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.3	0.5	-0.1
Light reinforcement 1	1.6	4.0	4.6	1.9	1.9	-2.2
Light reinforcement 2	0.1	0.2	0.3	-0.4	-0.6	0.2
Bone: marrow area	0.4	0.8	0.9	1.0	1.0	-0.8
Bone: maximum diameter	0.2	0.4	0.4	-0.6	-0.5	0.7
Bone: maximum force	0.1	0.2	0.2	0.5	0.5	-0.5
Bone: maximum moment	0.3	0.6	0.6	0.8	0.8	-0.8
Mean time between licks in bursts	0.1	0.2	0.3	-0.4	-0.5	0.3
Mean num. licks in bursts	1.5	2.3	2.4	1.6	1.5	-1.4
Cd content in liver	2.0	2.2	2.9	1.4	1.3	-1.7
Co content in liver	0.0	0.0	0.0	-0.1	-0.1	0.1
Cu content in liver	0.1	0.1	0.2	0.1	0.2	-0.4
Fe content in liver	1.2	1.4	1.6	1.2	1.3	-1.1
K content in liver	1.3	1.2	1.7	1.3	1.3	-0.7
Mg content in liver	0.1	0.1	0.1	0.2	0.2	0.4
Mn content in liver	0.4	0.5	0.5	0.7	0.7	-0.7
Na content in liver	0.0	0.0	0.1	-0.1	-0.1	0.2
Rb content in liver	1.9	2.2	3.0	1.3	1.3	-1.7
Se content in liver	0.8	1.0	1.3	-1.0	-0.9	1.1
Sr content in liver	2.5	2.2	2.7	-1.4	-1.4	1.6
Zn content in liver	0.2	0.2	0.2	0.4	0.5	-0.4
Bone: minimum diameter	2.7	4.9	4.9	2.2	2.2	-2.2
Time in familiar zone, hab. session 1	4.3	4.2	4.3	2.1	2.0	-2.1
Time in novel zone, hab. session 1	6.0	6.0	6.2	-2.5	-2.5	2.4
Total zone transitions, hab. session 1	0.0	0.0	0.0	0.1	0.2	0.1
Total locomotion distance, hab. session 1	0.1	0.1	0.3	0.3	0.5	0.1
Locomotion velocity, hab. session 1	0.1	0.1	0.2	0.3	0.5	0.1
Time in familiar zone, hab. session 2	1.7	1.8	2.1	1.4	1.4	-1.2
Time in novel zone, hab. session 2	2.2	2.2	2.5	-1.5	-1.6	1.4
Total zone transitions, hab. session 2	0.1	0.1	0.2	0.3	0.4	-0.2
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.0	0.2	0.4
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.3	0.5	0.1
Novel to familiar place preference ratio	2.0	2.1	2.7	-1.5	-1.6	1.2
Novelty place preference	1.5	1.6	2.1	-1.3	-1.4	0.9
Time in novel zone, NPP test	1.6	1.8	2.3	-1.4	-1.5	1.0
Total zone transitions, NPP test	1.3	1.9	2.2	1.4	1.5	-1.2
Total locomotion distance, NPP test	0.1	0.2	0.3	0.5	0.6	-0.2
Locomotion velocity, NPP test	0.7	0.9	1.3	1.0	1.1	-0.7
Intraocular pressure	3.7	5.3	5.9	-2.3	-2.4	2.1
Delta distance traveled before/after self-admin	1.0	1.0	1.2	1.1	1.0	-1.0
Delta ambulatory time before/after self-admin	0.8	1.0	1.0	1.0	1.0	-1.0
Parametrial fat weight	0.0	0.0	0.0	0.2	0.1	-0.2
Pavlov. Cond. lever latency	0.0	0.0	0.0	-0.1	-0.2	-0.1
Pavlov. Cond. magazine entry latency	1.5	2.0	2.6	1.5	1.6	-1.0
Pavlov. Cond. change in total contacts	3.3	3.5	3.7	1.9	1.9	-1.8
Pavlov. Cond. index score	0.5	0.7	0.9	0.9	1.0	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.3	0.5	0.6	-0.2
Pavlov. Cond. lever contacts	0.6	0.7	0.9	0.9	1.0	-0.6
Pavlov. Cond. magazine entry number	2.7	3.4	4.3	-2.0	-2.1	1.5
Pavlov. Cond. intertrial magazine entries	5.7	6.8	7.5	-2.6	-2.7	2.5
Pavlov. Cond. lever-magazine prob. diff.	0.8	0.9	1.2	1.0	1.1	-0.7
Pavlov. Cond. response bias	2.3	2.9	3.7	1.8	1.9	-1.3
Pavlov. Cond. lever latency	2.9	4.0	4.8	-1.9	-1.9	2.2
Pavlov. Cond. magazine entry latency	1.2	1.4	1.6	1.2	1.3	-1.0
Pavlov. Cond. change in total contacts	4.8	7.7	8.2	2.8	2.7	-2.9
Pavlov. Cond. index score	2.8	3.8	4.0	2.0	1.9	-2.0
Pavlov. Cond. latency score	2.9	3.9	4.0	2.0	1.9	-2.0
Pavlov. Cond. lever contacts	2.2	3.1	3.9	1.7	1.6	-2.0
Pavlov. Cond. magazine entry number	2.1	2.7	3.1	-1.7	-1.8	1.4
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.0	0.1	-0.4
Pavlov. Cond. lever-magazine prob. diff.	3.0	4.0	4.1	2.0	1.9	-2.0
Pavlov. Cond. response bias	1.7	2.3	2.5	1.5	1.5	-1.6
Time in closed arm before self-admin	0.1	0.2	0.3	0.5	0.5	-0.2
Time in closed arm after self-admin	0.2	0.2	0.6	-0.2	-0.2	0.8
Time in open arm before self-admin	0.3	0.3	0.5	0.4	0.4	-0.7
Time in open arm after self-admin	0.4	0.5	0.7	-0.7	-0.9	0.4
Bone: periosteal estimation	0.3	0.6	0.7	0.8	0.8	-0.8
Bone: periosteal perimeter	0.1	0.3	0.3	0.5	0.5	-0.5
Bone: post-yield work	0.2	0.3	0.3	0.6	0.5	-0.5
Progressive ratio test 1 active lever presses	2.3	2.8	3.4	1.8	1.5	-1.7
Progressive ratio test 1 breakpoint	2.6	3.2	3.8	1.9	1.6	-1.8
Progressive ratio test 1 inactive lever presses	0.8	1.2	1.5	1.2	0.9	-1.1
Progressive ratio test 2 active lever presses	2.4	2.8	3.5	1.9	1.6	-1.5
Progressive ratio test 2 breakpoint	2.6	2.9	3.7	1.9	1.7	-1.5
Progressive ratio test 2 inactive lever presses	0.7	1.1	1.6	1.3	0.8	-1.0
Incentive Sensitization - Responses	2.5	3.5	3.8	1.9	1.9	-1.7
Incentive Sensitization - Breakpoint	2.1	2.8	3.1	1.7	1.8	-1.5
Sum of active levers in priming session hrs 5-6	2.1	2.0	2.4	-1.5	-1.5	1.2
Progressive ratio	0.0	0.1	0.1	0.2	0.1	-0.3
Food seeking constrained by brief footshock	2.5	3.1	3.4	1.7	1.8	-1.8
Seeking ratio, punishment vs. effort	0.7	1.0	1.1	0.9	1.1	-1.0
Retroperitoneal fat weight	0.1	0.3	0.4	0.4	0.6	-0.5
Reaction time number correct	5.9	11.4	12.8	3.5	3.6	-3.1
Reaction time mean minus median	0.0	0.0	0.0	0.1	0.1	0.0
Reaction time mean minus median AUC	0.1	0.2	0.2	0.5	0.5	-0.3
Reaction time num false alarms	0.4	0.5	0.8	-0.9	-0.8	0.4
Reaction time num false alarms AUC	0.7	1.2	1.5	-1.2	-1.2	0.7
Reaction time trials correct on left	5.9	11.4	12.8	3.5	3.6	-3.1
Reaction time trials on left	6.1	11.5	12.9	3.5	3.6	-3.1
Reaction time mean	1.5	2.4	2.6	-1.6	-1.6	1.5
Reaction time mean AUC	1.3	2.0	2.1	-1.4	-1.5	1.4
Median of all reaction times	2.7	3.8	4.1	-2.0	-2.0	1.8
Reaction time omissions	0.2	0.4	0.6	0.5	0.5	-0.8
Reaction time false alarm rate	5.2	7.2	8.5	-2.8	-2.9	2.3
Reaction time premature initiation rate	4.0	5.5	6.1	2.4	2.2	-2.5
Reaction time premature initiations	8.8	15.7	16.5	4.1	3.9	-3.9
Std. dev. reaction times	0.2	0.3	0.4	-0.5	-0.5	0.7
Reaction time trials completed	6.1	11.5	12.9	3.5	3.6	-3.1
Reaction time trials AUC	5.5	10.4	11.7	3.3	3.4	-3.0
Run reversals in cocaine runway, females	0.6	0.6	1.1	-0.5	-0.6	1.0
Run reversals in cocaine runway, males	0.1	0.1	0.1	0.3	0.2	0.1
Latency to leave start box in cocaine runway	2.6	2.9	3.4	-1.7	-1.5	1.8
Latency to leave start box in cocaine runway, F	0.3	0.3	0.4	-0.5	-0.5	0.6
Latency to leave start box in cocaine runway, M	2.7	2.5	3.0	-1.6	-1.4	1.7
Std. dev. time between licks in bursts	0.6	0.9	1.0	-0.9	-0.8	1.0
Total sessions with >9 infusions	0.9	1.1	1.3	1.1	0.8	-1.1
Short access day 1 total inactive lever presses	1.1	1.4	2.2	1.1	1.0	-1.5
Short access day 10 total inactive lever presses	0.1	0.3	0.3	-0.5	-0.5	0.5
Short access day 1 total infusions	0.5	0.7	1.1	0.8	0.6	-1.0
Short access day 10 total infusions	1.7	2.2	2.5	1.6	1.3	-1.6
Short access total infusions	1.3	1.6	2.0	1.3	1.1	-1.4
Short access day 1 locomotion	0.1	0.2	0.2	0.5	0.3	-0.4
Short access day 10 total locomotion	0.4	0.7	0.8	-0.9	-0.9	0.8
Short access total locomotion	0.3	0.4	0.4	0.6	0.6	-0.6
One hour access (0.3 mA shock)	2.1	2.4	3.3	1.8	1.4	-1.4
Compulsive drug intake	1.6	1.9	2.2	-1.3	-1.3	1.5
One hour access (shock baseline)	3.2	4.9	5.7	2.4	2.0	-2.3
Social response proportion	0.0	0.0	0.0	-0.1	-0.1	0.1
Social responses	1.2	1.5	2.1	1.4	1.3	-0.9
Social time	0.0	0.0	0.0	-0.1	-0.1	-0.1
Soleus weight	0.2	0.6	0.9	-0.9	-0.9	0.4
Bone: stiffness	0.3	0.4	0.5	0.6	0.7	-0.7
Tibialis anterior weight	2.7	9.3	10.1	-3.0	-2.9	3.2
Time to tail flick, vehicle, before self-admin	1.7	1.8	2.3	1.2	1.3	-1.5
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.0	0.2	-0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.1	-0.3	-0.4	0.2
Time to tail flick, test, after self-admin	1.9	2.0	2.4	-1.3	-1.3	1.6
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.1	-1.0	-0.8	1.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.1	-0.1	-0.1	0.4
Tibia length	7.0	19.4	22.7	4.2	4.3	-4.8
Ambulatory time before self-admin	0.1	0.2	0.3	0.4	0.5	-0.2
Ambulatory time after self-admin	0.9	1.1	1.4	1.1	1.2	-0.9
Bone: tissue strength	0.8	0.8	0.9	-1.0	-0.9	0.8
Total heroin consumption	1.3	1.5	1.8	-1.3	-1.2	1.2
Bone: trabecular number	0.0	0.0	0.0	0.0	0.1	0.0
Bone: trabecular spacing	0.1	0.2	0.2	-0.4	-0.5	0.2
Bone: trabecular thickness	0.6	0.8	0.9	-0.8	-0.8	0.9
Bone: trabecular tissue density	2.4	3.6	4.0	-2.0	-1.9	1.8
Water consumed over 24 hours	0.4	0.6	0.7	-0.8	-0.8	0.6
Number of responses in last shaping day	0.5	0.6	0.9	-0.5	-1.0	0.8