Hub : Genes

Adamts3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Adamts3 0.63 0.1 0.0e+00 0.32 0.38 0.39 0.4 2.5e-38 1.9e-46 1.6e-48 4.3e-49
2 Brain mRNA stability Adamts3 0.07 0.03 1.1e-06 0.05 0.04 0.04 0.04 3.2e-05 2.9e-04 2.7e-04 1.5e-04
3 Liver mRNA stability Adamts3 0.07 0.04 4.5e-05 0.04 0.04 0.04 0.04 8.1e-05 3.1e-05 6.8e-05 8.5e-05
4 Liver gene expression Adamts3 0.03 0.02 2.0e-03 -0 -0 0 -0 5.2e-01 4.4e-01 1.7e-01 8.0e-01
5 NAcc intron excision ratio chr14_18231683_18232913 0.04 0.02 3.4e-06 0.06 0.05 0.04 0.05 1.1e-07 1.8e-06 4.0e-05 1.5e-06
6 IL gene expression Adamts3 0.22 0.11 7.7e-03 0 0.1 0.06 0.05 3.2e-01 2.0e-03 1.6e-02 2.0e-02
7 BLA mRNA stability Adamts3 0.17 0.09 3.2e-05 0.08 0.1 0.08 0.08 3.6e-05 7.2e-06 2.8e-05 4.8e-05
8 Brain gene expression Adamts3 0.17 0.03 5.6e-17 0.02 0.19 0.18 0.16 2.5e-03 1.3e-17 2.8e-16 1.2e-14
9 OFC gene expression Adamts3 0.28 0.13 2.5e-03 0.06 0.1 0.1 0.09 1.2e-02 2.8e-03 2.8e-03 3.2e-03
10 PL gene expression Adamts3 0.08 0.04 5.7e-05 0.04 0.05 0.05 0.05 1.0e-05 6.8e-06 2.1e-06 5.9e-06
11 pVTA gene expression Adamts3 0.19 0.09 2.4e-04 0.07 0.08 0.07 0.08 6.1e-04 1.7e-04 4.5e-04 2.1e-04
12 LHb gene expression Adamts3 0.36 0.15 1.9e-04 0.17 0.22 0.22 0.24 6.2e-05 6.7e-06 5.7e-06 1.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density1.11.85.12.12.1-2.3-0.51.60.3-2.00.10.60.5-0.60.3
Area under the delay curve0.80.93.2-0.3-0.2-0.4-0.7-0.9-0.3-0.4-0.6-1.80.2-1.6-1.5
BMI with tail1.23.810.53.03.2-3.0-2.81.81.0-1.11.10.11.4-0.9-0.2
BMI without tail0.10.30.60.50.5-0.8-0.30.6-0.1-0.7-0.10.20.8-0.6-0.7
Body weight0.31.23.2-1.40.2-0.51.20.3-1.8-1.4-1.8-0.71.1-0.6-0.6
Weight adjusted by age1.01.23.5-0.11.4-1.70.21.0-1.2-1.9-1.10.11.4-0.4-0.3
Bone surface0.61.13.11.01.3-1.20.41.80.0-1.40.01.30.00.71.2
Bone volume0.40.71.71.30.8-0.70.01.30.6-0.80.50.9-0.50.51.0
Breakpoint value in progressive ratio session0.10.10.4-0.10.10.10.10.6-0.00.00.10.4-0.10.60.6
Number of licking bursts1.41.74.2-1.40.8-1.10.40.1-2.1-1.7-2.0-0.31.7-0.9-1.2
Context. condit. distance diff. score4.14.911.11.8-1.62.2-1.9-1.03.33.23.20.6-3.11.11.0
Locomotion velocity, session 10.60.71.51.01.0-1.2-0.8-0.10.0-0.8-0.2-1.10.4-1.2-0.8
Locomotion distance, session 11.01.23.61.6-0.20.1-1.9-0.81.60.71.1-0.9-1.1-1.0-0.8
Locomotion velocity, session 20.20.31.10.8-0.1-0.2-0.6-0.10.5-0.00.2-1.1-0.6-0.8-0.1
Locomotion distance, session 20.50.81.90.7-0.50.1-1.2-1.00.70.50.4-1.4-0.6-1.2-1.0
Locomotion velocity, session 30.80.92.71.0-0.1-0.1-1.6-1.00.80.40.4-1.3-0.2-1.3-1.2
Locomotion distance, session 32.12.36.21.71.5-1.9-2.5-0.20.4-1.1-0.0-1.61.2-2.1-1.5
Stereotopy head waving bouts, day 30.40.41.5-0.3-0.30.1-0.7-1.0-0.30.3-0.4-0.70.5-1.0-1.2
Stereotopy head waving duration, day 30.30.31.00.1-0.70.7-0.5-1.00.50.90.4-0.1-0.3-0.4-0.7
Locomotion velocity, session 70.50.51.30.7-0.70.7-0.4-0.81.10.60.8-0.1-1.1-0.3-0.5
Locomotion distance, session 70.30.41.50.90.3-0.3-1.2-0.20.6-0.10.3-0.8-0.3-0.7-0.5
Stereotopy head waving bouts, day 70.10.10.20.30.4-0.5-0.30.1-0.0-0.10.10.40.4-0.1-0.2
Stereotopy head waving duration, day 70.10.10.2-0.00.5-0.5-0.3-0.1-0.20.1-0.0-0.20.5-0.3-0.2
Locomotion velocity, session 82.93.510.03.20.1-0.0-3.0-0.43.11.52.7-0.5-1.7-0.5-0.1
Locomotion distance, session 82.94.211.22.6-1.01.3-2.6-0.93.42.53.0-0.1-2.60.20.3
Degree of sensitization distance2.22.24.5-0.9-1.62.11.50.10.61.60.81.3-2.12.01.6
Degree of sensitization stereotypy0.10.10.3-0.30.3-0.50.2-0.1-0.5-0.1-0.3-0.10.5-0.3-0.4
Conditioned locomotion0.40.51.20.6-0.20.3-0.50.21.11.01.1-0.7-1.00.20.7
Cocaine response after cond. corrected0.20.20.9-0.7-0.90.70.2-0.4-0.30.3-0.3-0.20.10.0-0.4
Cocaine response after cond. not corrected0.10.10.6-0.0-0.50.50.30.40.20.20.30.8-0.00.60.3
Cocaine response before conditioning0.91.13.11.31.4-1.00.01.60.4-1.00.51.80.20.81.0
Saline control response0.40.51.71.0-0.60.7-0.1-0.11.20.40.90.4-1.30.40.4
Bone: connectivity density1.42.26.02.42.2-2.4-1.11.50.3-2.00.10.50.7-0.9-0.1
Bone: cortical apparent density0.60.82.20.10.6-1.20.0-0.4-0.6-0.8-0.8-1.21.1-1.5-1.3
Bone: cortical area1.32.04.01.5-0.10.70.11.31.70.61.72.0-1.71.71.8
Bone: cortical porosity0.50.51.70.11.1-1.3-0.10.1-0.7-0.7-0.5-0.31.1-0.8-0.6
Bone: cortical porosity0.50.51.70.11.2-1.30.20.4-0.7-0.8-0.50.21.1-0.5-0.4
Bone: cortical thickness1.83.07.72.81.2-0.5-0.72.12.10.22.22.3-1.31.51.9
Bone: cortical thickness1.11.33.90.6-0.40.81.11.10.70.10.82.0-1.41.61.6
Bone: cortical tissue density0.81.02.40.00.7-1.30.0-0.4-0.8-0.9-0.9-1.31.2-1.6-1.3
Condit. Reinf. active minus inactive responses1.01.22.9-1.20.3-0.71.6-0.2-1.7-1.1-1.6-0.21.3-0.7-0.8
Condit. Reinf. active-inactive response ratio0.91.03.6-1.00.6-0.71.90.1-1.6-0.5-1.10.61.3-0.1-0.3
Condit. Reinf. active responses0.50.61.3-0.60.1-0.50.9-0.6-1.0-0.9-1.1-0.60.5-0.8-0.7
Condit. Reinf. inactive responses0.10.10.40.3-0.3-0.0-0.4-0.30.3-0.6-0.1-0.5-0.7-0.30.0
Incentive salience index mean0.20.30.6-0.30.3-0.60.6-0.4-0.7-0.7-0.8-0.20.5-0.6-0.6
Condit. Reinf. lever presses0.20.20.60.70.8-0.8-0.40.10.2-0.70.00.1-0.2-0.20.1
Condit. Reinf. active minus inactive responses0.30.31.20.40.4-0.7-0.2-0.1-0.1-0.7-0.4-1.10.1-1.0-0.6
Condit. Reinf. active-inactive response ratio0.60.61.6-0.70.5-0.51.11.0-1.1-1.3-1.00.20.90.20.2
Condit. Reinf. active responses0.50.72.80.1-0.1-0.4-0.3-0.9-0.2-0.3-0.5-1.70.0-1.5-1.1
Condit. Reinf. inactive responses0.60.72.10.6-0.50.2-0.8-1.20.70.80.4-1.4-0.9-1.1-0.6
Condit. Reinf. lever presses0.60.82.6-0.9-1.61.21.1-1.1-0.20.5-0.4-0.8-1.0-0.4-0.5
Condit. Reinf. lever reinforcers received0.40.62.70.2-0.2-0.3-0.4-0.9-0.1-0.2-0.4-1.7-0.2-1.5-1.1
Conditioned reinforcement - actives0.40.41.5-0.8-0.50.30.3-0.9-0.30.7-0.3-1.2-0.1-0.6-0.5
Conditioned reinforcement - inactives1.01.12.6-0.6-1.31.60.90.00.61.40.70.4-1.31.21.3
Conditioned locomotion2.22.65.4-2.2-1.20.50.4-2.0-1.70.1-1.8-2.30.5-1.9-2.3
Patch foraging indifference point 0 sec0.71.23.00.70.4-0.7-1.7-1.20.30.10.0-1.40.9-1.7-1.7
Patch foraging indifference point AUC0.40.41.9-0.2-1.41.10.3-0.80.40.40.1-0.5-0.7-0.3-0.4
Delay disc. indifference point, 0s delay0.40.41.2-0.5-0.0-0.4-0.0-0.5-0.5-0.6-0.7-1.00.4-1.1-0.9
Delay disc. indifference point, 16s delay0.50.52.10.20.1-0.4-1.0-0.60.2-0.0-0.0-1.4-0.1-1.2-1.0
Delay disc. indifference point, 2s delay0.80.92.6-0.9-1.00.50.1-1.2-0.3-0.0-0.7-1.6-0.4-1.3-1.3
Delay disc. indifference point, 24s delay1.51.43.9-1.2-0.1-0.3-0.8-1.6-0.90.3-0.9-1.80.7-1.6-2.0
Delay disc. indifference point, 4s delay1.51.54.9-0.1-0.7-0.1-0.7-1.6-0.1-0.3-0.6-2.20.3-2.2-2.2
Delay disc. indifference point, 8s delay1.01.12.60.21.2-1.6-0.60.2-0.7-1.4-0.8-1.11.2-1.3-0.9
Indifference point function ln k0.20.31.20.30.4-0.10.10.50.30.10.51.1-0.20.70.6
Indifference point function log k0.20.31.20.30.4-0.10.10.50.30.10.51.1-0.20.70.6
Patch foraging total patch changes 0 sec0.61.02.50.60.3-0.5-1.6-1.10.30.30.1-1.20.8-1.5-1.6
Patch foraging total patch changes 12 sec0.70.92.80.4-0.60.3-1.2-1.40.70.80.3-1.7-0.2-1.3-1.1
Patch foraging total patch changes 18 sec0.20.20.6-0.20.2-0.40.1-0.3-0.6-0.3-0.6-0.50.8-0.6-0.6
Patch foraging total patch changes 24 sec1.72.14.60.6-0.50.5-1.9-2.21.11.50.7-2.10.0-1.8-1.9
Patch foraging total patch changes 6 sec0.91.33.80.5-0.4-0.0-1.6-1.60.40.30.0-1.60.4-1.9-1.9
Patch foraging time to switch 0 sec0.60.93.20.21.8-1.7-0.51.3-0.6-1.0-0.30.20.90.10.5
Patch foraging water rate 0 sec0.40.61.7-0.5-1.20.80.8-1.3-0.3-0.2-0.7-0.2-0.2-0.7-1.2
Patch foraging water rate 12 sec0.40.63.40.3-0.0-0.3-0.0-1.0-0.2-0.3-0.4-0.50.7-1.5-1.8
Patch foraging water rate 18 sec0.50.61.8-0.6-0.40.00.5-1.2-0.7-0.3-0.9-0.90.3-1.2-1.3
Patch foraging water rate 24 sec0.40.61.8-1.3-0.80.61.2-0.8-1.1-0.2-1.1-0.10.1-0.1-0.4
Patch foraging water rate 6 sec0.60.92.9-0.8-1.31.21.0-1.7-0.10.8-0.3-0.7-0.6-0.6-1.1
Seeking ratio, delayed vs. immediate footshock0.81.02.3-0.5-1.51.4-0.3-1.40.61.50.6-0.3-1.3-0.1-0.3
Distance traveled before self-admin1.11.22.9-1.6-1.41.20.1-1.7-0.51.4-0.4-1.2-0.7-0.4-0.9
Distance traveled after self-admin2.62.87.2-2.4-2.72.41.0-2.3-0.52.1-0.5-1.2-1.2-0.2-0.9
Extensor digitorum longus weight4.819.061.75.97.9-7.2-3.55.40.8-3.81.42.13.6-0.80.9
Bone: elastic displacement1.11.22.71.41.0-0.60.11.60.9-0.31.11.5-0.41.11.6
Bone: elastic work1.21.64.61.51.8-1.70.12.20.2-1.40.41.30.40.61.4
Bone: endosteal estimation0.71.65.0-2.2-1.82.01.7-1.0-0.90.6-0.9-0.1-0.60.70.2
Bone: endosteal perimeter0.30.62.0-1.4-0.91.01.0-0.1-0.8-0.2-0.80.3-0.10.70.5
Epididymis fat weight0.30.72.3-0.90.0-0.3-0.0-0.9-0.8-0.2-1.0-1.50.6-1.1-0.9
Delta time in closed arm before/after self-admin0.20.20.80.40.9-0.70.10.4-0.1-0.3-0.00.30.8-0.1-0.0
Delta time in open arm before/after self-admin0.40.41.2-0.4-1.00.7-0.2-0.80.10.2-0.3-1.1-0.8-0.5-0.5
Diff in mean of infusions in LGA sessions0.70.82.8-0.30.40.10.41.70.00.50.50.9-0.41.51.7
Delay discount exponential model param0.80.93.20.40.30.30.61.00.30.30.61.8-0.21.61.5
Extinction: sum of active levers before priming0.40.41.6-0.60.0-0.0-0.1-1.2-0.40.3-0.5-0.80.4-0.9-1.1
Active lever presses in extinction session 61.01.03.1-1.8-0.40.11.0-0.2-1.6-0.7-1.6-0.40.6-0.4-0.8
Bone: final force0.40.73.8-0.2-0.1-0.02.00.9-0.7-0.9-0.60.9-0.30.50.8
Bone: final moment0.50.84.9-0.5-0.2-0.12.20.5-1.1-1.0-1.00.6-0.00.10.3
Food consumed during 24 hour testing period0.20.21.40.80.2-0.4-1.20.20.4-0.30.3-0.1-0.2-0.2-0.1
Glucose0.50.82.1-1.1-1.51.40.6-1.3-0.30.8-0.4-0.6-0.5-0.4-0.8
Heart weight0.20.30.8-0.1-0.50.70.60.40.30.50.50.9-0.50.90.6
Delay discount hyperbolic model param1.11.14.20.30.50.20.71.30.20.20.52.0-0.11.91.7
Intermittent access intake day 1-15 change0.60.61.1-0.40.8-1.00.10.2-1.1-1.0-1.0-0.51.0-0.6-0.5
Intermittent access intake escalation0.60.61.6-1.00.5-0.70.1-0.1-1.3-0.6-1.1-0.91.0-0.7-0.6
Intermittent access intake escalation 21.11.13.9-2.0-1.20.91.0-0.9-1.30.1-1.3-1.1-0.2-0.5-0.6
Intermitt. access day 1 inactive lever presses3.03.29.62.80.10.3-2.00.23.12.03.00.1-1.40.61.1
Intermitt. access day 15 inactive lever presses2.02.26.90.1-0.61.21.11.60.80.51.02.1-1.32.52.6
Intermitt. access escalation Index1.71.53.3-0.51.3-0.71.51.6-0.9-0.6-0.31.80.31.61.8
Intermittent access day 1 total infusions0.80.92.4-1.0-1.51.50.3-1.40.21.50.2-0.6-0.80.0-0.3
Intermittent access day 15 total infusions1.01.13.0-1.7-1.41.40.5-1.5-0.51.3-0.5-1.1-0.6-0.2-0.4
Intermittent access terminal intake (last 3 days)2.12.36.0-2.5-2.22.31.2-1.9-0.61.8-0.6-0.9-1.20.2-0.2
Intermittent access total infusions1.01.13.2-1.8-1.51.50.7-1.4-0.61.3-0.5-0.8-0.6-0.1-0.4
Intermittent access day 1 locomotion0.50.51.8-0.9-0.91.10.3-1.10.01.30.1-0.6-0.60.0-0.2
Intermittent access day 15 total locomotion2.72.97.4-1.3-2.72.50.1-2.60.62.50.4-1.2-1.8-0.5-0.9
Intermittent access total locomotion1.31.53.3-1.8-1.71.40.5-1.8-0.61.3-0.6-1.3-0.6-0.7-1.1
Intermittent access standard deviation0.40.51.3-0.2-0.70.3-0.3-1.0-0.00.3-0.2-1.2-0.0-1.0-1.1
Left kidney weight0.41.02.9-1.7-1.51.51.7-0.6-0.80.1-0.9-0.0-0.60.5-0.0
Right kidney weight0.61.75.5-2.3-1.71.62.4-0.7-1.20.1-1.3-0.1-0.70.60.1
Cocaine induced anxiety1.01.22.8-1.10.3-0.01.71.6-1.1-0.8-0.81.20.41.21.2
Post-drug Anxiety0.30.31.1-1.0-0.70.61.00.1-0.6-0.1-0.6-0.3-0.30.20.2
Baseline Anxiety0.80.82.70.3-0.40.1-1.1-1.70.40.70.2-1.30.0-1.3-1.4
Tail length1.44.314.2-3.8-1.81.23.3-0.9-3.0-1.0-3.0-0.70.8-0.1-0.8
Length with tail2.07.324.3-4.9-3.83.24.0-2.0-2.70.5-2.8-1.3-1.00.5-0.4
Length without tail0.92.04.9-2.2-2.01.91.3-1.6-0.71.1-0.9-1.6-1.4-0.0-0.2
Times rat made contact with spout0.50.61.90.91.4-1.4-1.30.4-0.1-0.7-0.00.10.5-0.4-0.3
Lifetime Intake0.80.92.6-1.6-0.80.60.4-1.3-1.00.5-0.9-1.30.2-0.7-0.9
Liver weight, left1.42.36.8-0.5-0.1-0.7-0.3-1.9-1.0-0.8-1.5-2.60.9-2.6-2.2
Liver weight, right0.50.92.9-0.3-0.1-0.2-0.5-1.7-0.4-0.1-0.8-1.70.1-1.5-1.2
Locomotor activity0.20.41.4-0.1-0.70.5-0.1-1.20.20.1-0.2-1.0-0.4-0.7-0.7
Locomotor testing distance0.50.81.70.9-0.80.8-0.5-1.11.31.11.1-0.1-1.2-0.1-0.1
Locomotor testing rearing0.30.51.00.7-0.80.8-0.6-0.61.00.90.80.3-0.80.10.0
Locomotion in novel chamber0.50.62.00.10.1-0.3-0.9-1.20.10.1-0.1-1.20.5-1.3-1.4
Locomotion in novel chamber post-restriction0.81.02.0-0.9-1.10.40.9-1.1-0.8-0.5-1.2-1.3-0.1-1.3-1.4
Fecal boli incidents, locomotor time 11.01.14.1-0.80.6-0.62.01.2-1.1-1.6-1.10.70.60.50.6
Change in fecal boli incidents, locomotor task0.50.41.2-0.90.2-0.30.40.6-1.1-0.5-0.90.50.80.60.4
Time >=10cm from walls, locomotor time 11.11.13.7-1.10.8-0.80.90.7-1.5-1.4-1.40.11.90.20.1
Bouts of movement, locomotor time 10.20.20.6-0.5-0.80.8-0.0-0.20.00.70.20.6-0.20.5-0.0
Total resting periods, locomotor time 10.20.20.7-0.9-0.80.60.3-0.3-0.40.4-0.20.40.20.3-0.3
Rest time, locomotor task time 10.60.72.2-1.5-1.00.91.20.0-0.8-0.3-0.81.10.10.70.2
Distance moved, locomotor task time 10.50.51.01.00.9-1.0-1.0-0.10.2-0.5-0.0-1.00.1-1.0-0.5
Vertical activity count, locomotor time 10.70.73.1-0.20.1-0.2-0.5-1.2-0.30.3-0.5-1.8-0.1-1.4-1.1
Time >=10cm from walls, locomotor time 20.40.41.10.00.6-0.60.60.9-0.4-1.1-0.40.70.80.50.5
Bouts of movement, locomotor time 20.70.82.3-0.3-1.41.1-0.3-1.40.51.50.5-0.6-0.6-0.4-0.8
Total resting periods, locomotor time 20.60.61.7-0.3-1.31.0-0.2-1.20.31.30.3-0.4-0.5-0.4-0.7
Rest time, locomotor task time 20.80.92.7-0.9-1.61.60.7-0.70.31.50.50.7-0.60.70.2
Distance moved, locomotor task time 21.21.44.51.31.9-2.1-1.00.8-0.3-1.7-0.4-0.40.9-1.0-0.4
Vertical activity count, locomotor time 21.21.32.6-0.20.9-1.4-0.4-0.5-1.0-1.5-1.3-1.50.8-1.6-1.3
Light reinforcement 10.20.41.10.2-0.70.3-0.5-1.00.30.30.1-1.0-0.3-0.8-0.7
Light reinforcement 20.60.82.51.00.4-0.8-1.2-0.80.4-0.30.1-1.20.2-1.6-1.4
Bone: marrow area0.71.54.4-2.1-1.81.91.7-1.0-0.80.6-0.8-0.0-0.70.70.2
Bone: maximum diameter0.61.02.90.2-0.00.60.81.20.40.10.51.7-0.81.71.7
Bone: maximum force0.40.63.00.1-0.30.21.70.9-0.3-0.6-0.21.2-0.70.70.9
Bone: maximum moment0.30.64.1-0.3-0.30.12.00.5-0.7-0.7-0.60.9-0.30.30.4
Mean time between licks in bursts0.40.51.7-1.30.00.01.00.1-1.3-0.3-1.00.10.70.40.4
Mean num. licks in bursts1.11.43.61.7-0.30.5-1.10.01.91.31.80.1-1.50.51.0
Cd content in liver0.80.92.6-0.60.6-0.10.91.3-0.7-0.7-0.31.60.91.41.0
Co content in liver0.60.71.7-1.2-1.31.21.1-1.1-0.60.4-0.60.0-0.1-0.1-0.8
Cu content in liver0.60.81.70.4-1.31.2-0.4-1.20.90.80.5-0.4-1.3-0.5-0.7
Fe content in liver1.61.96.40.61.5-2.1-0.60.6-1.0-2.5-1.3-0.91.8-1.5-0.5
K content in liver1.71.73.71.2-0.40.2-1.8-1.81.41.00.8-1.9-1.0-1.6-1.2
Mg content in liver1.11.12.50.5-1.00.9-0.7-1.41.20.90.6-1.6-1.5-0.8-0.7
Mn content in liver0.60.71.91.30.5-0.2-1.4-0.01.40.61.2-0.4-0.8-0.20.3
Na content in liver2.52.79.11.10.1-0.7-1.4-2.30.3-0.4-0.4-2.00.4-3.0-3.0
Rb content in liver0.70.92.9-1.30.4-0.21.70.2-1.4-0.8-1.30.11.00.20.2
Se content in liver1.72.14.91.3-1.01.3-1.7-1.22.21.81.7-0.8-2.2-0.1-0.1
Sr content in liver3.12.87.90.3-0.51.21.21.61.10.81.42.8-1.62.82.4
Zn content in liver0.80.92.00.6-0.90.9-0.8-1.11.31.31.0-0.8-1.4-0.3-0.3
Bone: minimum diameter2.24.212.7-3.0-3.63.42.7-1.7-0.91.2-1.0-0.1-1.61.00.0
Time in familiar zone, hab. session 11.00.93.01.70.4-0.4-1.60.11.40.41.2-0.5-1.0-0.50.0
Time in novel zone, hab. session 12.32.28.2-2.9-0.60.62.1-0.6-2.4-0.5-2.1-0.31.40.3-0.3
Total zone transitions, hab. session 11.62.36.60.4-0.4-0.2-1.7-2.30.20.1-0.4-2.40.2-2.5-2.6
Total locomotion distance, hab. session 11.31.94.90.5-1.81.4-1.3-2.21.41.10.7-1.2-1.6-1.0-1.4
Locomotion velocity, hab. session 11.31.83.61.1-1.20.9-1.7-1.91.61.01.0-1.0-1.4-1.2-1.5
Time in familiar zone, hab. session 20.20.20.60.30.8-0.7-0.60.2-0.1-0.4-0.1-0.00.4-0.10.1
Time in novel zone, hab. session 20.40.41.9-0.7-1.11.01.4-0.1-0.20.5-0.00.2-0.40.40.0
Total zone transitions, hab. session 20.81.02.90.5-0.61.10.2-0.21.21.11.21.2-1.71.10.9
Total locomotion distance, hab. session 21.62.25.50.3-1.62.10.4-0.61.61.81.51.4-2.41.40.9
Locomotion velocity, hab. session 21.21.74.50.6-1.41.8-0.1-1.01.71.71.40.8-2.10.80.3
Novel to familiar place preference ratio0.20.20.8-0.0-0.40.00.2-0.7-0.2-0.1-0.3-0.70.1-0.9-0.8
Novelty place preference0.40.51.3-0.2-0.4-0.10.5-0.8-0.5-0.4-0.7-0.90.3-1.1-1.1
Time in novel zone, NPP test0.70.71.8-0.3-0.6-0.10.7-1.1-0.6-0.3-0.8-1.20.3-1.3-1.3
Total zone transitions, NPP test0.30.41.91.40.3-0.2-0.50.50.9-0.10.80.4-0.80.20.5
Total locomotion distance, NPP test0.30.41.71.3-0.40.2-0.7-0.41.00.20.70.2-0.8-0.4-0.5
Locomotion velocity, NPP test0.40.52.41.6-0.1-0.0-0.9-0.11.10.10.90.4-0.8-0.3-0.3
Intraocular pressure2.94.010.8-1.70.9-1.70.3-0.5-2.8-2.3-2.8-1.63.3-1.8-2.0
Delta distance traveled before/after self-admin0.10.10.6-0.5-0.50.40.8-0.0-0.20.1-0.20.20.10.20.1
Delta ambulatory time before/after self-admin0.10.10.4-0.30.10.10.70.3-0.2-0.1-0.10.50.40.40.3
Parametrial fat weight0.20.32.0-0.7-0.30.21.40.2-0.6-0.6-0.7-0.00.00.20.4
Pavlov. Cond. lever latency0.30.41.0-0.20.8-0.60.51.0-0.7-0.6-0.50.61.00.40.4
Pavlov. Cond. magazine entry latency0.20.20.60.30.1-0.3-0.4-0.60.30.20.1-0.7-0.3-0.8-0.6
Pavlov. Cond. change in total contacts0.20.21.10.2-0.50.4-0.2-0.30.60.60.5-0.3-1.0-0.00.2
Pavlov. Cond. index score0.40.51.00.8-0.1-0.1-0.9-0.90.80.30.4-0.9-0.6-1.0-0.8
Pavlov. Cond. latency score0.30.40.80.8-0.20.1-0.7-0.60.90.30.6-0.6-0.8-0.6-0.4
Pavlov. Cond. lever contacts0.30.41.50.4-0.80.7-0.3-0.60.90.50.6-0.3-1.2-0.10.0
Pavlov. Cond. magazine entry number0.10.20.5-0.5-0.10.20.30.5-0.4-0.2-0.30.40.40.70.6
Pavlov. Cond. intertrial magazine entries0.40.51.6-0.0-1.30.9-0.6-1.00.50.30.1-0.6-1.0-0.5-0.6
Pavlov. Cond. lever-magazine prob. diff.0.40.51.00.8-0.2-0.0-1.0-0.90.90.40.6-0.9-0.7-0.9-0.7
Pavlov. Cond. response bias0.30.41.10.0-0.50.2-0.2-1.10.30.30.0-1.0-0.7-0.8-0.7
Pavlov. Cond. lever latency0.10.10.30.2-0.10.2-0.30.20.40.50.50.5-0.20.50.5
Pavlov. Cond. magazine entry latency0.50.51.3-0.9-0.1-0.11.10.3-1.1-1.0-1.10.10.7-0.1-0.3
Pavlov. Cond. change in total contacts0.20.20.70.20.3-0.4-0.2-0.4-0.2-0.5-0.3-0.40.6-0.8-0.9
Pavlov. Cond. index score0.30.41.0-0.70.0-0.11.00.3-0.9-1.0-1.00.10.5-0.1-0.2
Pavlov. Cond. latency score0.20.20.7-0.30.2-0.20.80.6-0.6-0.8-0.60.40.30.20.2
Pavlov. Cond. lever contacts0.40.51.1-0.5-0.0-0.30.4-0.6-0.8-0.8-1.0-0.80.4-1.0-1.0
Pavlov. Cond. magazine entry number0.50.61.80.5-0.50.6-0.8-0.71.11.31.1-0.3-1.00.10.2
Pavlov. Cond. intertrial magazine entries0.20.21.1-0.1-0.40.5-0.0-0.40.30.40.2-0.2-1.10.40.8
Pavlov. Cond. lever-magazine prob. diff.0.20.30.9-0.6-0.1-0.10.90.3-0.8-0.9-0.90.00.4-0.0-0.1
Pavlov. Cond. response bias0.81.12.3-0.90.2-0.60.5-0.6-1.3-1.1-1.5-1.11.0-1.3-1.4
Time in closed arm before self-admin1.31.53.20.3-1.41.6-0.30.11.41.51.40.7-1.81.21.1
Time in closed arm after self-admin3.94.08.11.4-1.62.2-0.8-0.02.82.62.81.5-2.61.91.8
Time in open arm before self-admin1.41.63.9-0.51.8-1.81.10.8-1.6-1.5-1.30.12.0-0.3-0.2
Time in open arm after self-admin1.71.94.1-1.20.4-0.90.6-0.8-1.7-1.2-1.9-2.01.2-1.8-1.6
Bone: periosteal estimation0.51.02.4-0.6-1.11.51.20.20.20.60.21.1-1.21.51.2
Bone: periosteal perimeter0.20.31.00.2-0.40.70.20.50.40.20.41.0-0.60.90.8
Bone: post-yield work0.70.93.5-1.5-0.80.61.9-0.8-1.2-0.4-1.3-0.20.2-0.2-0.5
Progressive ratio test 1 active lever presses2.12.26.5-2.6-1.61.21.4-2.0-1.50.6-1.6-1.6-0.1-0.9-1.3
Progressive ratio test 1 breakpoint1.81.95.5-2.3-1.31.01.2-1.9-1.50.5-1.5-1.60.1-1.0-1.3
Progressive ratio test 1 inactive lever presses1.51.64.50.9-1.01.2-0.9-0.51.92.11.9-0.4-1.50.40.6
Progressive ratio test 2 active lever presses1.92.14.2-1.9-2.02.00.6-2.0-0.21.9-0.3-1.6-1.3-0.3-0.5
Progressive ratio test 2 breakpoint1.21.42.9-1.3-1.71.60.4-1.70.11.6-0.0-1.3-1.3-0.3-0.5
Progressive ratio test 2 inactive lever presses1.71.95.5-0.7-2.12.30.5-1.01.02.10.9-0.4-1.90.70.6
Incentive Sensitization - Responses1.21.22.8-1.4-1.31.70.8-0.50.11.70.3-0.3-1.51.01.1
Incentive Sensitization - Breakpoint1.31.33.1-1.5-1.31.80.9-0.50.11.70.3-0.3-1.61.11.1
Sum of active levers in priming session hrs 5-60.20.20.70.20.1-0.3-0.6-0.60.10.40.1-0.9-0.1-0.7-0.4
Progressive ratio0.20.31.40.31.2-1.0-0.70.4-0.1-0.30.10.20.1-0.1-0.2
Food seeking constrained by brief footshock0.20.20.50.30.5-0.6-0.5-0.0-0.0-0.4-0.1-0.00.4-0.7-0.7
Seeking ratio, punishment vs. effort0.10.10.70.1-0.80.60.1-0.30.40.30.2-0.1-0.3-0.00.0
Retroperitoneal fat weight0.41.33.2-1.8-1.10.71.3-1.3-1.1-0.3-1.5-1.50.3-0.8-1.1
Reaction time number correct0.40.51.7-1.00.0-0.20.9-0.1-1.3-0.9-1.30.10.5-0.2-0.4
Reaction time mean minus median0.81.02.4-0.90.3-0.81.00.2-1.5-1.4-1.6-0.61.2-0.7-0.7
Reaction time mean minus median AUC0.30.41.0-0.9-0.2-0.20.80.0-1.0-0.7-1.0-0.70.7-0.4-0.5
Reaction time num false alarms1.41.95.31.0-1.21.4-2.1-1.31.92.31.7-0.5-0.80.20.1
Reaction time num false alarms AUC1.11.64.20.9-0.80.9-2.1-1.51.52.01.4-0.9-0.4-0.4-0.4
Reaction time trials correct on left0.40.51.7-1.00.0-0.20.9-0.1-1.3-0.9-1.30.10.5-0.2-0.4
Reaction time trials on left0.40.61.8-1.00.1-0.21.0-0.0-1.3-1.0-1.30.10.5-0.3-0.4
Reaction time mean0.50.72.2-1.0-0.20.51.50.9-0.6-0.2-0.40.7-0.01.31.2
Reaction time mean AUC0.40.61.9-1.0-0.40.81.40.5-0.40.2-0.30.6-0.21.21.0
Median of all reaction times0.70.92.9-0.9-0.20.81.40.9-0.20.30.01.0-0.31.71.6
Reaction time omissions0.50.61.7-0.20.7-0.90.90.7-1.0-1.3-1.0-0.21.0-0.4-0.2
Reaction time false alarm rate1.42.05.41.1-0.81.0-2.3-1.31.92.31.8-1.0-0.7-0.3-0.2
Reaction time premature initiation rate0.91.22.40.8-1.31.3-0.8-0.91.51.51.3-0.1-1.60.10.1
Reaction time premature initiations0.50.71.90.3-1.41.3-0.4-1.00.81.00.6-0.2-1.3-0.1-0.2
Std. dev. reaction times0.20.31.2-0.9-0.40.31.10.1-0.7-0.3-0.7-0.10.30.1-0.1
Reaction time trials completed0.40.61.8-1.00.1-0.21.0-0.0-1.3-1.0-1.30.10.5-0.3-0.4
Reaction time trials AUC0.60.82.5-1.20.1-0.31.20.0-1.6-1.2-1.50.10.7-0.2-0.4
Run reversals in cocaine runway, females0.10.10.20.4-0.10.10.5-0.20.3-0.20.20.3-0.5-0.00.2
Run reversals in cocaine runway, males0.40.41.2-0.00.9-0.70.31.1-0.3-0.7-0.20.30.30.50.8
Latency to leave start box in cocaine runway1.21.33.9-1.3-1.72.01.0-0.8-0.11.30.00.9-1.21.10.3
Latency to leave start box in cocaine runway, F1.92.16.1-1.3-2.52.50.7-1.60.41.90.30.2-2.00.6-0.2
Latency to leave start box in cocaine runway, M1.51.42.6-0.81.1-0.61.31.3-1.4-1.3-1.11.61.11.21.1
Std. dev. time between licks in bursts0.70.91.6-0.80.7-0.9-0.3-0.6-1.2-0.8-1.2-1.31.1-1.0-0.8
Total sessions with >9 infusions2.52.86.3-0.91.7-2.1-0.1-0.3-2.2-1.7-2.0-1.22.5-1.7-1.7
Short access day 1 total inactive lever presses0.60.72.30.1-0.61.0-0.4-0.41.01.51.1-0.3-1.00.50.6
Short access day 10 total inactive lever presses2.73.07.02.3-0.50.8-0.81.22.61.32.61.8-1.81.61.9
Short access day 1 total infusions0.30.30.6-0.50.2-0.3-0.3-0.7-0.6-0.2-0.7-0.80.6-0.6-0.6
Short access day 10 total infusions0.60.72.1-0.8-0.60.30.1-1.4-0.50.6-0.5-1.30.2-1.1-1.2
Short access total infusions0.91.01.7-0.80.7-0.90.1-0.7-1.3-0.7-1.2-1.21.3-1.1-1.0
Short access day 1 locomotion2.12.34.9-1.70.0-0.70.0-1.4-2.1-0.9-2.1-1.61.5-1.8-2.2
Short access day 10 total locomotion0.50.52.6-0.5-0.81.0-0.2-0.90.51.60.6-0.4-0.70.20.0
Short access total locomotion0.40.50.8-0.90.3-0.40.1-0.8-0.90.0-0.8-0.80.7-0.7-0.9
One hour access (0.3 mA shock)2.42.87.0-2.6-1.91.31.4-2.1-1.70.1-2.0-1.8-0.1-1.3-1.7
Compulsive drug intake1.31.44.72.21.5-1.4-1.01.40.9-1.00.91.00.60.20.6
One hour access (shock baseline)2.93.39.7-3.1-1.91.51.5-2.4-1.80.8-1.9-2.2-0.1-1.2-1.7
Social response proportion0.60.61.6-0.7-0.0-0.40.4-0.4-1.0-0.9-1.1-0.61.3-0.8-1.1
Social responses0.60.82.4-0.7-0.40.0-0.1-1.6-0.60.1-0.8-1.40.7-1.1-1.2
Social time0.30.41.1-0.7-1.00.9-0.9-0.7-0.20.3-0.4-0.30.30.0-0.5
Soleus weight2.16.118.64.32.1-1.1-3.51.23.71.73.70.7-1.90.31.4
Bone: stiffness0.40.71.8-0.2-1.30.70.7-1.2-0.20.1-0.5-0.8-0.7-1.1-1.3
Tibialis anterior weight1.65.615.33.93.9-3.6-3.22.21.4-1.01.60.41.4-1.00.1
Time to tail flick, vehicle, before self-admin0.70.72.3-1.5-1.00.81.30.1-1.0-0.5-1.10.1-0.70.30.2
Time to tail flick, vehicle, after self-admin1.11.22.90.3-1.61.4-0.7-1.31.31.71.1-0.8-1.1-0.3-0.4
Time to tail flick, test, before self-admin0.60.51.30.6-0.10.4-0.40.31.01.01.10.4-0.90.71.0
Time to tail flick, test, after self-admin1.51.54.3-2.1-2.02.00.8-1.4-0.51.1-0.7-0.8-0.90.2-0.2
Delta time to tail flick, vehicle, before/after SA0.90.92.01.2-0.30.1-1.4-1.11.21.11.1-1.0-0.1-0.9-0.8
Delta time to tail flick, test, before/after SA1.11.02.1-1.4-1.41.20.6-1.5-0.50.4-0.9-1.2-0.4-0.5-0.7
Tibia length2.05.711.5-2.0-2.83.33.10.30.31.60.41.7-3.03.43.0
Ambulatory time before self-admin1.71.74.6-1.4-1.71.5-0.3-2.1-0.21.8-0.2-1.6-0.9-0.8-1.4
Ambulatory time after self-admin2.62.97.0-2.2-2.62.30.7-2.6-0.52.0-0.5-1.3-1.0-0.6-1.4
Bone: tissue strength0.50.51.0-0.6-0.90.30.7-0.8-0.5-0.1-0.6-0.80.1-0.8-1.0
Total heroin consumption0.91.13.8-1.9-1.61.51.1-0.9-0.81.0-0.7-0.0-0.60.3-0.2
Bone: trabecular number0.81.33.91.71.7-2.0-0.90.80.1-1.6-0.1-0.10.5-1.1-0.4
Bone: trabecular spacing0.60.72.2-0.1-1.11.3-0.3-0.70.91.50.9-0.1-0.90.50.2
Bone: trabecular thickness0.30.31.11.10.7-0.8-0.20.80.2-0.80.00.2-0.1-0.10.2
Bone: trabecular tissue density0.10.10.5-0.50.1-0.10.7-0.3-0.5-0.3-0.40.30.2-0.0-0.2
Water consumed over 24 hours0.10.10.5-0.10.1-0.3-0.5-0.2-0.3-0.4-0.4-0.20.2-0.4-0.7
Number of responses in last shaping day1.01.12.90.91.3-1.7-1.1-0.2-0.2-1.0-0.3-1.11.3-1.3-0.9