Hub : Genes

Adamts3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Adamts3 0.55 0.11 0.0e+00 0.34 0.41 0.41 0.41 6.1e-54 4.0e-66 1.2e-67 1.1e-67
2 Brain mRNA stability Adamts3 0.09 0.04 3.1e-07 0.07 0.08 0.08 0.08 3.9e-07 5.8e-08 1.1e-07 1.0e-07
3 NAcc mRNA stability Adamts3 0.02 0.01 6.1e-03 0.01 0 0.01 0.01 5.2e-03 8.7e-02 3.3e-02 9.8e-03
4 IC gene expression Adamts3 0.31 0.11 7.2e-09 0.18 0.14 0.19 0.17 4.1e-08 1.3e-06 2.7e-08 1.1e-07
5 Liver gene expression Adamts3 0.03 0.02 3.3e-03 -0 -0 -0 -0 6.8e-01 7.4e-01 7.6e-01 7.7e-01
6 Liver mRNA stability Adamts3 0.07 0.04 5.3e-05 0.04 0.04 0.05 0.03 2.3e-05 7.3e-05 5.8e-06 3.2e-04
7 NAcc intron excision ratio chr14_18515804_18517034 0.08 0.03 6.2e-15 0.1 0.11 0.1 0.1 1.4e-15 8.0e-16 5.2e-15 3.2e-15
8 BLA mRNA stability Adamts3 0.12 0.07 3.0e-04 0.07 0.08 0.06 0.06 1.5e-04 6.0e-05 5.5e-04 2.5e-04
9 OFC gene expression Adamts3 0.2 0.11 3.5e-03 0.07 0.12 0.1 0.1 8.8e-03 7.9e-04 2.5e-03 2.4e-03
10 PL gene expression Adamts3 0.07 0.04 1.5e-04 0.04 0.04 0.04 0.04 1.5e-05 6.6e-05 4.5e-05 8.2e-05
11 pVTA gene expression Adamts3 0.16 0.07 8.1e-08 0.08 0.11 0.09 0.1 3.0e-07 5.7e-09 1.7e-07 2.1e-08
12 Brain gene expression Adamts3 0.2 0.06 7.2e-16 0.07 0.19 0.19 0.18 8.8e-07 2.7e-17 1.1e-17 5.4e-17
13 LHb gene expression Adamts3 0.38 0.15 1.2e-04 0.24 0.23 0.23 0.24 2.1e-06 4.3e-06 3.0e-06 1.7e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.81.44.31.9-2.11.8-0.8-0.21.3-0.8-1.90.70.3-0.5-0.10.3
Area under the delay curve0.81.33.8-0.2-0.40.6-0.6-1.70.71.5-0.3-2.0-0.6-1.80.6-1.6
BMI with tail1.55.216.54.1-3.53.41.1-3.12.7-1.2-1.20.21.3-1.5-1.0-0.6
BMI without tail0.31.43.61.7-1.91.90.8-1.51.4-1.1-0.80.50.9-0.3-0.1-0.3
Body weight0.10.30.8-0.6-0.3-0.0-0.3-0.60.50.3-0.8-0.50.1-0.50.9-0.5
Weight adjusted by age0.51.43.4-0.0-1.41.31.6-0.01.3-1.2-1.81.11.50.21.10.3
Bone surface0.50.92.20.8-0.91.0-0.71.10.2-1.4-1.21.50.10.8-0.21.2
Bone volume0.30.62.31.1-0.50.4-1.50.8-0.1-0.7-0.60.7-0.60.5-0.40.9
Breakpoint value in progressive ratio session0.30.51.10.30.50.2-0.40.7-0.5-0.70.70.6-0.51.0-1.01.0
Number of licking bursts0.31.02.8-1.5-0.90.71.0-0.81.10.2-1.70.21.1-0.81.2-1.0
Context. condit. distance diff. score3.34.09.72.12.0-1.6-2.40.4-2.50.43.1-0.2-2.91.0-3.01.0
Locomotion velocity, session 10.80.91.90.9-1.41.0-0.5-1.21.40.3-1.0-0.90.4-1.30.3-0.8
Locomotion distance, session 11.11.45.01.6-0.1-0.1-2.2-0.90.01.10.7-1.3-1.4-1.1-1.7-0.7
Locomotion velocity, session 20.40.42.10.8-0.20.1-1.4-0.00.20.6-0.0-1.1-0.7-0.7-0.5-0.1
Locomotion distance, session 20.71.03.80.70.0-0.3-2.0-0.5-0.11.20.5-1.6-1.2-1.2-0.8-0.8
Locomotion velocity, session 30.80.92.21.1-0.2-0.1-1.5-1.00.31.10.3-1.4-0.7-1.3-0.2-1.1
Locomotion distance, session 31.82.14.61.8-2.11.5-0.8-2.11.80.5-1.2-1.30.5-1.90.4-1.4
Stereotopy head waving bouts, day 30.40.41.7-0.30.1-0.20.2-0.9-0.21.00.1-0.70.2-1.00.4-1.3
Stereotopy head waving duration, day 30.40.41.10.10.8-0.8-0.4-0.3-0.81.00.9-0.5-0.5-0.4-0.4-0.9
Locomotion velocity, session 70.80.83.40.60.7-1.3-1.90.1-0.61.00.7-0.6-1.4-0.3-0.8-0.3
Locomotion distance, session 70.30.42.20.7-0.40.1-1.5-0.20.10.5-0.2-0.8-0.7-0.6-0.6-0.2
Stereotopy head waving bouts, day 70.30.41.80.4-0.70.91.3-0.30.5-0.4-0.30.40.7-0.20.2-0.3
Stereotopy head waving duration, day 70.20.31.00.1-0.50.71.0-0.60.6-0.1-0.1-0.10.6-0.30.4-0.5
Locomotion velocity, session 81.72.010.73.3-0.20.2-1.9-0.8-0.30.41.5-0.9-1.6-0.5-2.30.1
Locomotion distance, session 82.43.49.62.71.0-0.9-3.00.2-1.60.62.5-0.8-2.70.1-3.10.5
Degree of sensitization distance2.32.55.4-0.92.2-1.6-0.72.3-2.3-0.21.70.7-1.61.8-1.21.6
Degree of sensitization stereotypy0.30.31.4-0.1-0.50.71.2-0.60.5-0.1-0.20.00.6-0.40.5-0.6
Conditioned locomotion0.20.30.90.70.10.1-0.60.4-0.0-0.30.8-0.6-0.70.3-0.51.0
Cocaine response after cond. corrected0.10.20.5-0.70.7-0.70.00.2-0.50.50.4-0.4-0.2-0.10.4-0.4
Cocaine response after cond. not corrected0.10.10.50.00.4-0.40.20.7-0.5-0.10.30.5-0.10.5-0.20.2
Cocaine response before conditioning0.91.13.01.3-0.91.10.70.80.6-1.4-0.91.70.80.8-0.71.0
Saline control response0.40.62.81.10.5-0.6-1.70.6-0.40.30.5-0.2-0.90.2-1.20.4
Bone: connectivity density1.11.75.22.2-2.32.0-0.7-0.51.2-0.8-1.90.70.4-0.7-0.40.1
Bone: cortical apparent density1.11.83.5-0.0-1.61.21.0-1.91.60.6-1.3-1.11.1-1.91.3-1.5
Bone: cortical area1.21.93.61.30.8-0.6-1.51.9-1.2-1.00.81.6-1.01.8-1.81.7
Bone: cortical porosity0.60.61.20.1-1.11.11.1-1.00.90.0-0.6-0.20.8-0.90.6-0.7
Bone: cortical porosity0.80.92.3-0.0-1.31.51.5-0.81.0-0.5-1.00.41.1-0.60.7-0.4
Bone: cortical thickness1.22.17.12.7-0.51.0-1.01.2-0.3-1.70.21.9-0.41.4-2.11.7
Bone: cortical thickness1.31.54.80.41.0-0.6-1.02.2-1.3-0.80.31.6-0.81.7-1.41.5
Bone: cortical tissue density1.32.03.8-0.1-1.71.31.2-2.01.70.6-1.4-1.11.3-1.91.5-1.6
Condit. Reinf. active minus inactive responses0.91.04.0-1.3-0.60.41.6-0.90.50.2-1.10.01.0-0.72.0-0.7
Condit. Reinf. active-inactive response ratio1.11.17.3-1.1-0.50.72.7-0.30.2-0.4-0.70.81.2-0.11.5-0.2
Condit. Reinf. active responses0.40.51.7-0.7-0.50.20.3-0.80.40.5-0.9-0.40.2-0.91.3-0.6
Condit. Reinf. inactive responses0.30.32.90.3-0.1-0.1-1.7-0.10.40.4-0.5-0.6-0.5-0.3-0.2-0.0
Incentive salience index mean0.20.31.0-0.4-0.50.30.6-0.70.20.2-0.7-0.00.3-0.61.0-0.5
Condit. Reinf. lever presses0.10.20.70.5-0.70.7-0.40.10.3-0.3-0.80.30.0-0.1-0.10.3
Condit. Reinf. active minus inactive responses0.20.30.50.3-0.70.5-0.7-0.40.60.3-0.7-0.7-0.0-0.70.3-0.3
Condit. Reinf. active-inactive response ratio0.30.41.5-0.8-0.30.30.70.30.3-0.5-1.10.50.90.41.20.2
Condit. Reinf. active responses0.40.62.00.0-0.3-0.0-1.0-0.60.41.1-0.4-1.4-0.4-1.30.3-0.9
Condit. Reinf. inactive responses0.50.82.60.50.2-0.5-1.6-0.4-0.21.10.6-1.4-1.2-0.9-0.8-0.4
Condit. Reinf. lever presses0.91.32.9-1.01.5-1.7-1.70.6-1.31.40.8-1.1-1.5-0.2-0.1-0.3
Condit. Reinf. lever reinforcers received0.40.62.10.1-0.3-0.1-1.1-0.60.21.1-0.2-1.5-0.7-1.20.1-0.8
Conditioned reinforcement - actives0.10.41.2-0.30.6-0.2-0.2-0.6-0.40.90.8-1.1-0.8-0.6-0.2-0.6
Conditioned reinforcement - inactives0.82.34.9-0.12.1-1.6-1.41.7-2.10.22.2-0.1-1.61.3-1.61.3
Conditioned locomotion1.62.35.8-1.91.1-1.7-0.7-1.3-0.62.40.7-2.3-1.2-1.70.7-1.9
Patch foraging indifference point 0 sec0.51.45.00.5-0.80.4-0.0-2.21.21.2-0.2-1.40.5-1.80.6-2.0
Patch foraging indifference point AUC0.30.82.90.01.1-1.6-1.70.1-0.31.10.7-0.9-0.9-0.1-0.2-0.3
Delay disc. indifference point, 0s delay0.50.61.5-0.4-0.40.1-0.1-1.00.81.0-0.5-1.1-0.0-1.20.8-1.0
Delay disc. indifference point, 16s delay0.40.61.60.4-0.51.2-0.6-1.10.50.7-0.0-1.3-0.6-1.1-0.2-0.8
Delay disc. indifference point, 2s delay1.21.33.6-0.70.5-1.1-1.0-1.0-0.31.80.2-1.9-1.3-1.30.6-1.4
Delay disc. indifference point, 24s delay1.01.54.6-1.3-0.10.80.5-1.90.31.50.2-1.7-0.4-1.80.4-2.1
Delay disc. indifference point, 4s delay1.92.15.30.1-0.3-0.3-1.4-1.90.82.1-0.3-2.3-0.7-2.20.9-2.2
Delay disc. indifference point, 8s delay0.71.22.50.1-1.51.60.5-1.41.50.1-1.4-0.70.6-1.30.9-1.0
Indifference point function ln k0.10.30.90.0-0.10.40.50.8-0.7-0.70.01.00.00.6-0.40.6
Indifference point function log k0.10.30.90.0-0.10.40.50.8-0.7-0.70.01.00.00.6-0.40.6
Patch foraging total patch changes 0 sec0.41.24.30.5-0.60.20.0-2.11.01.1-0.0-1.30.5-1.60.5-1.9
Patch foraging total patch changes 12 sec0.70.92.70.70.1-0.6-1.2-1.40.71.20.6-1.6-0.4-1.10.1-1.1
Patch foraging total patch changes 18 sec0.10.31.1-0.2-0.40.30.2-0.61.10.4-0.4-0.40.7-0.60.5-0.6
Patch foraging total patch changes 24 sec0.61.94.90.70.3-0.8-1.1-2.10.52.01.2-2.2-0.6-1.7-0.2-2.1
Patch foraging total patch changes 6 sec1.01.64.40.5-0.1-0.7-1.1-2.10.81.90.3-1.9-0.2-1.80.3-1.9
Patch foraging time to switch 0 sec0.41.64.10.1-1.82.02.0-0.21.4-1.6-1.40.91.40.10.80.6
Patch foraging water rate 0 sec0.20.82.4-0.61.0-1.5-1.20.1-0.61.6-0.0-0.6-0.6-0.60.4-1.0
Patch foraging water rate 12 sec0.20.83.10.2-0.2-0.5-0.1-1.30.31.4-0.2-0.9-0.0-1.50.4-1.8
Patch foraging water rate 18 sec0.20.51.5-0.70.1-0.5-0.3-0.40.41.2-0.2-0.90.1-1.10.7-1.1
Patch foraging water rate 24 sec0.30.41.6-1.30.7-1.00.20.5-0.50.7-0.1-0.1-0.0-0.10.9-0.4
Patch foraging water rate 6 sec0.81.12.7-0.81.3-1.4-1.20.3-1.21.61.0-1.0-1.2-0.6-0.2-1.0
Seeking ratio, delayed vs. immediate footshock0.71.02.9-0.11.2-0.4-1.00.1-1.61.11.4-0.8-1.7-0.3-0.8-0.6
Distance traveled before self-admin0.20.31.2-1.10.8-0.7-0.20.0-0.60.50.9-0.6-0.7-0.1-0.0-0.2
Distance traveled after self-admin1.83.18.0-2.02.8-2.1-1.30.5-2.12.22.5-1.5-2.0-0.2-0.5-0.7
Extensor digitorum longus weight5.622.258.85.4-7.47.74.4-3.05.9-5.0-4.53.55.0-0.6-0.10.9
Bone: elastic displacement0.81.02.11.3-0.40.80.11.10.1-1.4-0.01.40.11.2-1.41.5
Bone: elastic work1.31.73.41.4-1.41.70.71.11.2-1.8-1.11.70.90.8-0.71.4
Bone: endosteal estimation0.71.85.7-2.32.2-2.4-0.81.5-1.20.80.8-0.1-0.71.00.50.2
Bone: endosteal perimeter0.30.72.0-1.41.2-1.3-0.31.4-0.5-0.00.00.5-0.11.00.40.5
Epididymis fat weight0.21.23.6-0.9-0.3-0.0-0.3-1.60.71.4-0.3-1.90.2-1.70.8-1.7
Delta time in closed arm before/after self-admin0.70.63.60.3-0.91.90.8-0.61.0-0.2-0.60.10.9-0.50.2-0.4
Delta time in open arm before/after self-admin0.40.52.1-0.00.6-1.1-1.40.3-0.60.30.5-0.7-1.10.2-0.30.5
Diff in mean of infusions in LGA sessions1.01.75.1-0.40.70.30.71.4-1.1-1.91.01.7-0.42.2-1.02.3
Delay discount exponential model param1.01.34.10.30.3-0.40.61.7-0.5-1.60.12.00.81.8-0.61.7
Extinction: sum of active levers before priming0.20.41.0-0.7-0.21.01.0-0.60.30.5-0.1-0.40.2-0.80.2-0.8
Active lever presses in extinction session 60.70.73.1-1.80.6-0.70.2-0.4-0.61.1-0.3-0.6-0.4-0.60.9-1.1
Bone: final force0.20.31.7-0.40.2-0.2-0.51.3-0.2-0.3-0.70.9-0.00.60.20.7
Bone: final moment0.20.20.9-0.80.1-0.2-0.21.00.00.0-0.80.60.10.20.60.2
Food consumed during 24 hour testing period0.10.20.60.8-0.50.4-0.8-0.20.3-0.1-0.3-0.1-0.1-0.2-0.4-0.1
Glucose0.50.82.4-1.31.1-1.5-0.4-0.5-0.51.20.6-0.9-0.4-0.40.9-0.6
Heart weight0.30.51.40.5-0.00.40.20.4-0.1-1.20.31.20.21.2-0.60.8
Delay discount hyperbolic model param1.11.54.50.20.2-0.20.91.7-0.4-1.70.12.10.91.9-0.51.7
Intermittent access intake day 1-15 change0.21.33.8-0.7-1.00.70.5-1.91.00.8-0.9-1.40.7-1.61.4-1.5
Intermittent access intake escalation0.21.23.3-0.6-1.10.90.4-1.81.10.6-1.0-1.20.8-1.41.4-1.4
Intermittent access intake escalation 20.91.44.0-1.10.8-1.0-1.3-1.0-0.71.90.5-2.0-1.0-1.20.7-1.3
Intermitt. access day 1 inactive lever presses0.11.64.22.00.7-0.7-1.80.1-0.70.42.0-0.9-1.50.1-2.00.5
Intermitt. access day 15 inactive lever presses0.52.76.20.02.1-1.2-1.32.5-2.2-0.51.71.1-1.52.2-1.31.9
Intermitt. access escalation Index0.72.15.4-1.2-0.20.92.31.9-0.2-2.0-0.42.11.21.50.51.8
Intermittent access day 1 total infusions0.20.71.7-0.81.3-0.8-0.80.7-0.90.51.2-0.3-1.00.4-0.90.3
Intermittent access day 15 total infusions0.41.02.0-1.01.2-0.8-1.2-0.4-0.81.41.2-1.4-0.9-0.6-0.3-0.8
Intermittent access terminal intake (last 3 days)1.62.75.4-1.32.3-1.5-2.20.2-2.02.02.2-1.8-2.0-0.4-0.8-0.6
Intermittent access total infusions1.01.12.4-0.81.6-0.7-1.40.1-1.21.31.5-1.0-1.4-0.1-0.8-0.4
Intermittent access day 1 locomotion0.30.51.0-0.71.0-0.6-0.70.5-0.70.41.0-0.4-0.90.2-0.80.3
Intermittent access day 15 total locomotion1.03.77.2-0.52.4-2.1-2.70.1-2.12.52.5-2.0-2.5-0.6-1.4-0.7
Intermittent access total locomotion1.01.23.0-1.51.1-1.1-0.8-0.6-0.81.70.7-1.5-1.1-0.90.1-1.2
Intermittent access standard deviation0.21.12.70.40.8-0.4-1.6-0.8-0.71.41.3-1.5-1.3-0.8-0.8-0.8
Left kidney weight0.10.41.1-0.20.5-0.8-1.10.9-0.6-0.3-0.10.6-0.70.8-0.00.8
Right kidney weight0.21.33.3-1.81.4-1.5-0.71.8-1.2-0.10.00.7-0.61.30.70.9
Cocaine induced anxiety0.51.42.9-1.3-0.20.31.71.3-0.3-1.6-0.91.70.81.51.11.2
Post-drug Anxiety0.50.61.9-0.3-0.10.50.90.6-0.3-1.4-0.21.10.21.30.41.3
Baseline Anxiety0.30.51.31.00.10.9-0.6-0.7-0.00.41.1-0.6-0.5-0.4-1.1-0.2
Tail length0.73.919.3-4.42.7-2.9-0.91.2-1.91.70.7-1.1-1.10.31.9-0.7
Length with tail1.56.631.5-5.63.7-3.7-1.12.7-2.61.60.6-0.6-1.31.22.20.1
Length without tail0.31.76.0-2.51.8-1.9-1.01.9-1.20.50.3-0.3-1.00.90.60.9
Times rat made contact with spout0.60.72.70.8-1.51.60.4-0.51.0-0.6-1.10.50.6-0.5-0.2-0.1
Lifetime Intake0.30.41.2-0.90.5-0.0-0.5-0.7-0.11.00.4-1.1-0.5-0.70.1-0.9
Liver weight, left1.01.74.4-1.0-0.1-0.5-1.0-1.80.72.0-0.6-2.10.1-2.01.1-1.7
Liver weight, right0.81.43.6-0.3-0.20.1-1.0-1.70.81.8-0.2-1.90.2-1.90.1-1.7
Locomotor activity0.40.62.8-0.10.6-0.7-1.7-0.0-0.21.20.3-1.2-0.6-0.7-0.1-0.4
Locomotor testing distance0.30.82.10.70.9-0.4-1.41.0-0.90.51.1-0.1-0.80.2-1.40.6
Locomotor testing rearing0.20.61.60.90.8-0.6-1.30.6-1.00.60.9-0.2-0.80.1-1.20.0
Locomotion in novel chamber0.50.62.1-0.4-0.30.20.4-1.30.60.90.0-0.90.2-1.10.5-1.4
Locomotion in novel chamber post-restriction0.20.51.5-0.60.2-0.4-0.5-0.4-0.11.2-0.3-1.1-0.7-1.01.0-0.9
Fecal boli incidents, locomotor time 10.40.92.8-0.6-0.51.11.30.80.4-0.9-1.31.00.60.71.70.7
Change in fecal boli incidents, locomotor task0.40.41.2-1.1-0.20.51.10.30.3-0.7-0.60.71.10.40.40.2
Time >=10cm from walls, locomotor time 11.11.34.5-1.3-0.81.01.40.11.5-0.8-1.50.62.10.31.5-0.0
Bouts of movement, locomotor time 10.20.20.7-0.50.9-0.30.20.4-0.80.10.80.3-0.30.5-0.3-0.0
Total resting periods, locomotor time 10.20.20.7-0.80.7-0.70.50.2-0.60.30.50.2-0.10.20.2-0.3
Rest time, locomotor task time 10.50.82.0-1.41.3-0.70.51.4-1.20.00.30.9-0.21.00.30.4
Distance moved, locomotor task time 10.20.51.30.9-1.20.6-0.6-1.00.90.0-0.7-0.6-0.0-0.9-0.2-0.4
Vertical activity count, locomotor time 10.10.61.9-0.3-0.40.3-0.8-1.20.30.9-0.1-1.4-0.3-1.30.3-0.9
Time >=10cm from walls, locomotor time 20.20.51.2-0.1-0.51.00.40.60.8-0.9-1.00.91.10.50.40.4
Bouts of movement, locomotor time 20.20.81.8-0.11.0-0.5-0.7-0.4-0.81.31.3-1.0-1.0-0.6-0.8-0.9
Total resting periods, locomotor time 20.10.61.4-0.10.9-0.5-0.6-0.3-0.71.21.1-0.8-0.8-0.6-0.8-0.8
Rest time, locomotor task time 20.60.92.6-0.71.6-1.40.00.9-1.50.61.50.2-0.60.6-0.80.2
Distance moved, locomotor task time 21.01.34.11.0-2.01.60.5-1.11.6-0.6-1.80.00.8-1.00.8-0.5
Vertical activity count, locomotor time 20.61.42.9-0.6-1.31.2-0.1-1.51.20.5-1.6-1.00.4-1.51.7-1.1
Light reinforcement 10.10.41.50.20.2-0.1-0.9-0.10.31.10.4-1.2-0.4-0.9-0.2-0.6
Light reinforcement 20.40.92.50.8-0.90.7-0.3-1.30.90.9-0.4-1.2-0.1-1.60.1-1.4
Bone: marrow area0.71.75.5-2.12.2-2.3-0.91.5-1.20.70.8-0.1-0.81.00.40.3
Bone: maximum diameter0.61.23.5-0.00.8-0.6-0.31.8-0.7-1.10.31.6-0.21.9-0.71.5
Bone: maximum force0.20.42.3-0.20.4-0.4-0.61.5-0.3-0.3-0.51.0-0.30.7-0.10.7
Bone: maximum moment0.10.31.5-0.60.4-0.5-0.41.2-0.10.1-0.60.7-0.10.40.30.3
Mean time between licks in bursts0.10.62.2-1.5-0.10.31.50.40.4-0.3-0.60.20.90.11.00.0
Mean num. licks in bursts0.30.72.91.70.3-0.1-1.00.5-0.6-0.31.1-0.1-0.90.5-1.20.9
Cd content in liver2.22.56.40.5-1.01.42.50.60.8-2.5-0.62.51.91.70.11.5
Co content in liver0.30.41.8-1.00.9-1.30.30.4-1.00.20.20.5-0.10.50.2-0.1
Cu content in liver0.40.51.9-0.30.6-1.4-1.20.1-0.41.0-0.0-0.5-0.5-0.40.2-0.7
Fe content in liver1.41.76.6-0.8-1.40.11.10.31.9-0.3-2.60.32.0-0.51.9-0.2
K content in liver0.80.82.90.9-0.1-0.5-1.7-0.70.00.90.4-1.4-0.9-1.0-0.7-0.6
Mg content in liver0.30.42.30.10.3-0.8-1.50.3-0.10.50.1-0.9-0.8-0.2-0.20.1
Mn content in liver0.30.31.61.3-0.70.5-0.6-0.10.8-0.2-0.1-0.20.0-0.2-0.60.2
Na content in liver1.92.26.00.6-0.7-1.0-1.1-2.01.12.1-0.8-1.7-0.1-2.40.4-2.4
Rb content in liver0.80.92.6-1.5-0.4-0.81.60.40.7-0.6-1.10.71.30.31.40.2
Se content in liver0.70.83.10.20.5-0.4-1.8-0.1-0.21.20.7-1.6-1.0-0.8-0.7-0.3
Sr content in liver3.42.97.00.91.1-0.2-0.32.6-1.7-1.71.12.3-0.72.6-1.82.4
Zn content in liver0.20.21.00.7-0.00.3-1.0-0.2-0.00.30.2-0.6-0.4-0.3-0.40.0
Bone: minimum diameter2.75.216.1-2.93.7-4.0-2.31.7-2.72.01.8-0.8-2.31.00.3-0.2
Time in familiar zone, hab. session 10.60.72.71.6-0.50.4-1.6-0.10.40.00.2-0.5-0.9-0.4-1.50.3
Time in novel zone, hab. session 11.31.47.7-2.80.7-0.71.7-0.2-0.20.4-0.4-0.11.10.12.3-0.6
Total zone transitions, hab. session 11.82.56.50.3-0.3-0.4-1.8-1.90.52.40.1-2.5-0.8-2.5-0.0-2.4
Total locomotion distance, hab. session 12.02.89.30.61.3-1.8-3.0-0.6-1.22.31.3-1.9-2.2-1.1-1.4-1.2
Locomotion velocity, hab. session 11.62.37.31.10.8-1.3-2.7-0.8-0.92.01.1-1.7-2.0-1.2-1.6-1.2
Time in familiar zone, hab. session 20.20.20.60.1-0.70.80.30.20.6-0.5-0.60.30.6-0.1-0.20.2
Time in novel zone, hab. session 20.30.31.0-0.51.0-1.00.20.0-0.90.40.7-0.1-0.60.30.5-0.1
Total zone transitions, hab. session 21.11.43.20.41.1-0.8-1.61.4-1.5-0.01.10.7-1.60.9-1.81.0
Total locomotion distance, hab. session 22.22.85.90.42.1-1.9-2.21.4-2.40.41.90.6-2.31.3-1.91.1
Locomotion velocity, hab. session 21.82.46.20.71.8-1.8-2.50.8-2.10.81.80.1-2.30.7-1.90.5
Novel to familiar place preference ratio0.30.41.00.0-0.0-0.2-0.0-0.9-0.00.9-0.1-0.8-0.2-0.90.7-1.0
Novelty place preference0.50.61.7-0.2-0.1-0.20.0-1.00.21.1-0.4-1.0-0.1-1.21.1-1.3
Time in novel zone, NPP test0.70.82.0-0.3-0.1-0.40.0-1.10.21.4-0.3-1.3-0.2-1.41.3-1.4
Total zone transitions, NPP test0.30.51.71.3-0.30.3-1.30.60.1-0.30.00.2-0.50.1-1.20.6
Total locomotion distance, NPP test0.40.62.21.20.2-0.5-1.5-0.3-0.50.70.4-0.3-1.1-0.4-1.0-0.4
Locomotion velocity, NPP test0.40.52.21.5-0.0-0.2-1.4-0.2-0.30.40.2-0.0-0.9-0.2-1.2-0.1
Intraocular pressure2.13.48.2-1.9-1.30.91.6-1.71.80.8-2.1-1.02.4-1.82.9-2.4
Delta distance traveled before/after self-admin0.50.61.7-0.81.3-1.0-0.50.1-0.61.30.8-0.7-0.5-0.30.1-0.6
Delta ambulatory time before/after self-admin0.10.20.6-0.60.8-0.30.20.1-0.10.70.4-0.20.2-0.00.2-0.3
Parametrial fat weight0.30.71.9-1.41.0-1.2-1.30.7-0.60.80.1-0.7-0.40.00.6-0.1
Pavlov. Cond. lever latency0.60.82.4-0.2-0.80.91.60.30.9-1.0-0.81.01.50.40.70.2
Pavlov. Cond. magazine entry latency0.20.31.30.4-0.60.4-0.2-1.10.50.4-0.2-0.5-0.0-0.8-0.0-0.6
Pavlov. Cond. change in total contacts0.30.31.20.20.4-0.3-1.1-0.4-0.60.40.6-0.5-1.1-0.1-0.80.2
Pavlov. Cond. index score0.50.61.50.8-0.2-0.1-1.2-1.20.11.00.2-1.1-0.9-1.0-0.4-0.7
Pavlov. Cond. latency score0.30.41.50.80.0-0.3-1.2-0.8-0.20.70.4-0.8-0.9-0.6-0.6-0.3
Pavlov. Cond. lever contacts0.50.52.30.40.6-0.8-1.5-0.1-0.70.80.5-0.7-1.2-0.3-0.7-0.1
Pavlov. Cond. magazine entry number0.20.20.7-0.30.1-0.10.50.8-0.0-0.6-0.20.50.50.60.40.4
Pavlov. Cond. intertrial magazine entries0.80.93.10.10.9-1.1-1.80.4-1.01.20.5-1.0-1.4-0.5-0.6-0.6
Pavlov. Cond. lever-magazine prob. diff.0.50.71.80.8-0.1-0.2-1.4-1.10.01.00.3-1.1-1.0-1.0-0.5-0.7
Pavlov. Cond. response bias0.50.61.50.1-0.1-0.2-1.1-1.10.01.10.0-1.2-0.7-1.1-0.1-0.8
Pavlov. Cond. lever latency0.10.20.40.10.3-0.00.50.4-0.2-0.40.60.4-0.00.6-0.40.6
Pavlov. Cond. magazine entry latency0.20.21.0-1.00.0-0.20.50.0-0.20.1-0.70.20.2-0.00.9-0.4
Pavlov. Cond. change in total contacts0.10.20.60.2-0.30.0-0.4-0.50.20.5-0.4-0.40.2-0.70.2-0.8
Pavlov. Cond. index score0.10.10.4-0.70.0-0.3-0.20.2-0.10.2-0.60.10.0-0.00.6-0.3
Pavlov. Cond. latency score0.00.10.4-0.3-0.1-0.0-0.10.4-0.2-0.2-0.60.40.10.20.30.0
Pavlov. Cond. lever contacts0.20.30.6-0.60.2-0.5-0.7-0.2-0.20.8-0.4-0.6-0.3-0.50.5-0.7
Pavlov. Cond. magazine entry number0.30.41.70.60.6-0.4-0.70.1-0.50.31.3-0.5-0.80.1-1.10.4
Pavlov. Cond. intertrial magazine entries0.10.20.7-0.10.4-0.2-0.80.8-0.5-0.00.3-0.2-0.60.3-0.40.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.4-0.70.1-0.4-0.30.2-0.20.2-0.50.0-0.00.00.6-0.3
Pavlov. Cond. response bias0.30.51.2-1.0-0.1-0.3-0.2-0.60.10.9-0.7-0.70.1-0.91.0-1.1
Time in closed arm before self-admin1.62.77.9-0.11.9-2.8-1.52.0-2.0-0.31.60.8-1.41.8-1.41.7
Time in closed arm after self-admin2.83.26.21.02.2-1.5-2.51.9-2.10.12.40.4-1.71.6-2.41.6
Time in open arm before self-admin2.22.77.1-1.0-1.62.52.7-1.31.8-0.3-1.70.11.9-1.01.9-1.3
Time in open arm after self-admin1.01.12.5-1.2-0.70.30.7-1.30.90.7-1.0-1.20.3-1.31.6-1.2
Bone: periosteal estimation0.71.74.0-0.81.8-1.8-1.32.0-1.4-0.20.80.9-0.91.7-0.61.1
Bone: periosteal perimeter0.30.61.70.10.9-0.9-0.81.3-0.6-0.30.50.8-0.41.1-0.70.7
Bone: post-yield work0.30.62.9-1.70.8-1.1-0.30.5-0.20.8-0.4-0.1-0.2-0.01.0-0.4
Progressive ratio test 1 active lever presses0.61.13.7-1.91.4-0.9-0.70.2-1.01.50.7-1.1-1.0-0.50.3-0.8
Progressive ratio test 1 breakpoint0.61.13.4-1.81.4-0.9-0.70.2-1.01.50.8-1.1-1.0-0.50.1-0.8
Progressive ratio test 1 inactive lever presses0.71.84.30.81.4-0.6-1.80.9-1.50.22.1-0.4-1.90.8-2.10.9
Progressive ratio test 2 active lever presses1.42.04.0-1.21.9-2.0-1.60.1-1.51.61.8-1.6-1.8-0.2-0.5-0.4
Progressive ratio test 2 breakpoint1.62.03.9-1.21.9-2.0-1.70.2-1.51.61.8-1.5-1.8-0.2-0.6-0.4
Progressive ratio test 2 inactive lever presses1.03.27.3-0.42.6-1.9-2.71.2-2.31.22.5-0.9-2.30.8-1.50.5
Incentive Sensitization - Responses0.61.53.6-1.01.7-1.7-1.20.7-1.60.51.9-0.8-1.60.7-0.90.7
Incentive Sensitization - Breakpoint0.71.63.7-1.01.7-1.7-1.20.8-1.60.51.9-0.8-1.60.7-0.90.8
Sum of active levers in priming session hrs 5-60.40.42.50.6-0.31.6-0.3-0.50.40.10.6-0.7-0.4-0.5-0.8-0.1
Progressive ratio0.00.10.30.2-0.4-0.20.3-0.4-0.5-0.4-0.10.3-0.4-0.00.1-0.1
Food seeking constrained by brief footshock0.20.20.60.4-0.70.0-0.0-0.80.80.1-0.60.10.3-0.6-0.3-0.5
Seeking ratio, punishment vs. effort0.10.21.10.10.7-0.5-1.00.20.20.60.4-0.4-0.10.0-0.70.2
Retroperitoneal fat weight0.10.63.7-1.90.4-0.8-0.4-0.10.20.6-0.7-0.60.5-0.21.3-0.3
Reaction time number correct0.10.21.5-1.20.1-0.10.10.10.10.3-0.80.20.3-0.10.6-0.5
Reaction time mean minus median0.10.93.6-1.2-0.80.41.2-0.70.60.1-1.5-0.20.7-0.71.9-0.7
Reaction time mean minus median AUC0.10.42.1-1.0-0.2-0.10.7-0.50.10.2-0.7-0.40.2-0.41.4-0.5
Reaction time num false alarms0.91.64.91.11.3-0.9-2.2-0.2-1.20.82.2-0.9-0.90.2-1.9-0.2
Reaction time num false alarms AUC0.51.23.41.00.8-0.6-1.8-0.8-0.70.91.9-1.1-0.6-0.3-1.6-0.6
Reaction time trials correct on left0.10.21.5-1.20.1-0.10.10.10.10.3-0.80.20.3-0.10.6-0.5
Reaction time trials on left0.10.31.6-1.30.0-0.10.20.10.10.2-0.80.20.3-0.10.7-0.5
Reaction time mean0.30.71.4-1.20.5-0.40.91.1-0.6-0.8-0.10.80.21.20.51.2
Reaction time mean AUC0.20.61.6-1.30.8-0.60.71.1-0.8-0.50.20.60.11.10.31.0
Median of all reaction times0.71.02.6-1.10.8-0.60.71.6-0.9-1.00.41.00.11.60.01.6
Reaction time omissions0.20.31.1-0.0-0.70.30.6-0.40.4-0.3-1.10.20.4-0.11.1-0.2
Reaction time false alarm rate0.91.24.51.30.8-0.5-1.5-0.8-0.70.82.1-1.2-0.7-0.3-1.6-0.3
Reaction time premature initiation rate1.11.74.60.91.4-1.5-2.10.4-1.51.01.8-0.7-1.80.1-1.60.2
Reaction time premature initiations0.51.64.60.21.5-1.6-2.20.4-1.41.21.4-0.7-1.70.0-1.2-0.2
Std. dev. reaction times0.10.21.2-1.10.3-0.60.5-0.1-0.40.1-0.3-0.10.10.11.0-0.1
Reaction time trials completed0.10.31.6-1.30.0-0.10.20.10.10.2-0.80.20.3-0.10.7-0.5
Reaction time trials AUC0.10.42.1-1.4-0.0-0.10.30.20.20.2-1.00.30.5-0.10.9-0.5
Run reversals in cocaine runway, females0.30.31.50.10.5-1.1-0.81.2-0.40.40.10.1-0.40.1-0.20.4
Run reversals in cocaine runway, males0.50.51.60.3-0.80.80.30.40.6-1.3-0.60.70.80.60.11.1
Latency to leave start box in cocaine runway1.21.74.9-1.42.1-1.9-0.51.2-2.20.71.40.3-1.20.8-0.50.3
Latency to leave start box in cocaine runway, F2.32.98.3-1.02.5-2.3-1.60.9-2.91.52.1-0.6-2.40.3-1.0-0.0
Latency to leave start box in cocaine runway, M1.01.02.7-1.20.20.21.31.30.1-0.9-0.81.61.21.10.70.7
Std. dev. time between licks in bursts0.40.71.3-0.9-0.80.80.7-0.91.10.3-0.9-0.70.9-0.91.1-0.8
Total sessions with >9 infusions1.72.23.9-1.0-1.51.11.6-2.01.80.6-1.5-0.91.3-1.91.5-1.9
Short access day 1 total inactive lever presses0.40.82.7-0.11.1-0.5-1.00.1-1.10.71.6-0.9-1.40.0-1.00.2
Short access day 10 total inactive lever presses0.53.36.42.11.5-0.6-1.92.0-2.1-0.72.10.9-2.01.9-2.52.0
Short access day 1 total infusions0.30.61.6-0.20.0-0.1-0.7-1.00.21.20.2-1.2-0.2-1.2-0.1-1.3
Short access day 10 total infusions0.61.02.6-0.10.00.1-0.6-1.40.41.50.4-1.6-0.5-1.50.0-1.6
Short access total infusions0.60.81.8-0.5-0.91.00.6-1.31.20.4-0.7-0.80.6-1.20.8-1.2
Short access day 1 locomotion1.83.08.9-1.6-0.8-0.30.8-2.51.12.0-1.0-1.80.4-2.61.7-3.0
Short access day 10 total locomotion0.10.41.40.10.6-0.3-0.6-0.5-0.50.71.2-0.7-0.8-0.3-0.8-0.4
Short access total locomotion0.71.03.0-0.9-0.40.30.4-1.70.71.2-0.2-1.30.1-1.60.7-1.7
One hour access (0.3 mA shock)1.61.84.8-2.21.5-0.9-0.9-0.3-1.22.20.5-1.8-1.4-1.01.1-1.3
Compulsive drug intake0.60.93.41.6-1.01.80.50.40.7-1.1-0.81.00.70.40.10.7
One hour access (shock baseline)0.92.46.1-2.01.3-1.7-1.2-1.2-0.72.50.8-2.4-1.2-1.50.5-1.8
Social response proportion0.30.41.0-0.5-0.40.30.2-0.60.60.4-0.9-0.30.7-0.71.0-0.8
Social responses0.40.51.2-0.70.00.2-0.4-0.60.41.0-0.0-1.10.3-1.10.5-1.0
Social time0.20.30.9-0.60.9-0.9-0.6-0.1-0.80.70.5-0.4-0.30.1-0.1-0.7
Soleus weight1.23.618.24.3-1.42.1-1.5-0.4-0.1-1.41.30.5-1.20.2-3.71.4
Bone: stiffness0.71.23.5-0.30.7-1.3-1.8-0.3-0.51.90.1-1.2-1.2-1.20.3-1.2
Tibialis anterior weight1.65.516.23.7-3.94.01.2-2.62.6-1.9-1.50.81.7-1.1-0.8-0.0
Time to tail flick, vehicle, before self-admin0.91.12.8-1.51.2-1.7-0.70.6-1.51.10.1-0.5-1.5-0.10.3-0.4
Time to tail flick, vehicle, after self-admin0.61.32.5-0.21.5-1.3-1.50.1-0.91.41.6-1.2-1.4-0.3-1.2-0.4
Time to tail flick, test, before self-admin1.01.12.80.10.9-0.6-0.11.6-1.2-0.81.10.9-0.81.4-1.21.7
Time to tail flick, test, after self-admin1.31.44.9-2.01.7-2.2-0.50.9-1.21.00.8-0.7-0.80.30.3-0.0
Delta time to tail flick, vehicle, before/after SA0.30.30.70.8-0.10.2-0.6-0.60.60.50.6-0.80.1-0.7-0.7-0.4
Delta time to tail flick, test, before/after SA0.60.71.8-1.10.6-1.2-0.7-0.3-0.01.3-0.1-1.3-0.2-0.80.9-1.0
Tibia length2.46.720.9-1.83.4-2.3-1.94.6-3.5-0.81.91.3-1.93.3-1.42.9
Ambulatory time before self-admin0.20.71.8-0.60.9-1.0-0.7-0.4-0.80.91.3-1.0-1.1-0.4-0.4-0.5
Ambulatory time after self-admin2.03.27.8-1.52.8-2.4-1.50.4-2.02.32.5-1.5-2.1-0.2-0.6-0.8
Bone: tissue strength0.30.30.8-0.30.3-0.5-0.4-0.4-0.30.90.0-0.8-0.6-0.70.5-0.7
Total heroin consumption0.70.84.1-2.01.2-1.40.30.3-1.10.70.8-0.2-0.60.10.1-0.2
Bone: trabecular number0.51.02.91.6-1.71.5-1.1-0.41.0-0.3-1.50.10.0-0.8-0.30.0
Bone: trabecular spacing0.30.41.90.01.0-0.9-0.3-0.0-0.80.41.4-0.5-0.70.2-0.6-0.2
Bone: trabecular thickness0.20.31.00.9-0.70.4-1.00.00.5-0.2-0.90.2-0.2-0.2-0.00.2
Bone: trabecular tissue density0.20.41.4-0.6-0.40.31.2-0.10.80.2-0.70.01.0-0.50.6-0.5
Water consumed over 24 hours0.00.10.20.0-0.30.4-0.20.00.2-0.1-0.50.30.1-0.10.0-0.2
Number of responses in last shaping day1.21.63.70.3-1.51.00.1-1.81.70.7-1.1-1.40.6-1.90.7-1.6