Hub : Genes

Adam4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Adam4	0.08	0.05	6.5e-04	0.01	0.02	0.02	0.02	4.1e-02	7.5e-03	1.4e-02	4.5e-03
2	Adipose	gene expression	Adam4	0.04	0.02	4.6e-05	0.03	0.04	0.03	0.03	3.0e-04	7.7e-05	1.9e-04	3.7e-04
3	NAcc	gene expression	Adam4	0.03	0.02	4.8e-04	0.02	0.01	0.02	0.01	2.9e-04	2.5e-03	4.3e-04	3.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.1	0.2	0.3	0.4	0.1	-0.6
Area under the delay curve	0.3	0.4	0.8	-0.2	-0.9	0.7
BMI with tail	1.6	5.6	12.9	3.6	1.2	-1.6
BMI without tail	0.1	0.3	0.9	-0.2	-0.9	-0.3
Body weight	0.8	3.6	5.7	-1.9	-2.4	1.1
Weight adjusted by age	0.7	2.2	3.9	-2.0	-1.5	0.6
Bone surface	0.1	0.1	0.4	0.2	-0.2	-0.6
Bone volume	0.0	0.1	0.2	-0.1	-0.1	-0.4
Breakpoint value in progressive ratio session	0.1	0.2	0.3	-0.4	0.2	-0.5
Number of licking bursts	0.6	1.9	3.2	1.8	1.0	-1.2
Context. condit. distance diff. score	2.1	2.5	2.9	-1.5	-1.6	1.7
Locomotion velocity, session 1	0.7	0.8	1.3	0.3	1.1	-1.2
Locomotion distance, session 1	2.1	2.6	4.0	2.0	1.4	-1.4
Locomotion velocity, session 2	0.3	0.4	0.7	0.7	0.8	-0.2
Locomotion distance, session 2	3.3	4.7	5.8	2.4	2.1	-1.9
Locomotion velocity, session 3	1.7	1.9	2.8	-1.6	-0.6	1.7
Locomotion distance, session 3	0.3	0.4	0.6	-0.6	-0.4	0.8
Stereotopy head waving bouts, day 3	0.7	0.8	1.1	-1.0	-0.9	0.7
Stereotopy head waving duration, day 3	0.3	0.3	0.9	-0.9	-0.2	0.3
Locomotion velocity, session 7	0.1	0.1	0.2	-0.2	0.3	0.5
Locomotion distance, session 7	0.3	0.3	0.9	0.9	0.3	0.1
Stereotopy head waving bouts, day 7	2.6	3.0	5.6	-2.4	-1.4	1.1
Stereotopy head waving duration, day 7	2.6	3.2	6.3	-2.5	-1.4	1.1
Locomotion velocity, session 8	0.2	0.2	0.5	0.4	0.7	-0.1
Locomotion distance, session 8	0.1	0.1	0.4	0.6	-0.0	0.2
Degree of sensitization distance	0.1	0.1	0.2	0.4	0.0	-0.2
Degree of sensitization stereotypy	3.2	3.5	6.4	-2.5	-1.6	1.3
Conditioned locomotion	0.2	0.3	0.6	-0.1	0.8	-0.5
Cocaine response after cond. corrected	0.3	0.5	1.0	0.6	1.0	-0.2
Cocaine response after cond. not corrected	0.8	1.1	2.1	1.0	1.4	-0.6
Cocaine response before conditioning	0.4	0.5	0.6	0.6	0.7	-0.8
Saline control response	0.6	0.8	1.5	1.2	0.6	-0.8
Bone: connectivity density	0.2	0.4	0.7	0.8	-0.1	-0.7
Bone: cortical apparent density	0.3	0.4	0.9	0.4	-0.5	0.9
Bone: cortical area	1.0	1.6	3.2	-1.8	-1.0	0.8
Bone: cortical porosity	1.5	1.7	2.6	-1.6	-1.3	0.8
Bone: cortical porosity	2.0	2.2	3.2	-1.8	-1.6	0.9
Bone: cortical thickness	0.2	0.4	0.5	-0.6	-0.6	0.7
Bone: cortical thickness	0.3	0.4	0.6	0.8	0.7	0.1
Bone: cortical tissue density	0.2	0.3	0.7	0.4	-0.4	0.9
Condit. Reinf. active minus inactive responses	3.6	4.0	4.4	-2.1	-1.9	2.0
Condit. Reinf. active-inactive response ratio	4.4	4.7	5.3	-2.3	-2.0	2.2
Condit. Reinf. active responses	3.3	4.2	4.7	-1.9	-2.1	2.2
Condit. Reinf. inactive responses	0.1	0.2	0.4	0.7	-0.2	-0.0
Incentive salience index mean	2.4	3.1	3.4	-1.9	-1.6	1.8
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.7	-0.4	0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	0.7	-0.4	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.7	-0.0	-0.9	0.5
Condit. Reinf. active responses	0.0	0.1	0.2	-0.1	-0.4	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.4	0.3	-0.2
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.3	-0.4	0.0
Condit. Reinf. lever reinforcers received	0.0	0.1	0.2	0.1	-0.4	0.1
Conditioned reinforcement - actives	0.1	0.2	0.6	0.1	0.8	-0.3
Conditioned reinforcement - inactives	0.3	0.8	1.2	0.5	1.1	-0.9
Conditioned locomotion	0.6	0.9	1.7	0.9	1.3	-0.5
Patch foraging indifference point 0 sec	0.1	0.3	0.8	0.0	-0.0	-0.9
Patch foraging indifference point AUC	0.3	0.6	1.0	-0.6	-0.8	1.0
Delay disc. indifference point, 0s delay	0.3	0.3	0.9	0.9	-0.3	-0.1
Delay disc. indifference point, 16s delay	1.1	1.6	2.9	-1.7	-1.0	1.0
Delay disc. indifference point, 2s delay	0.3	0.4	0.9	0.2	-0.9	0.4
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	-0.5	-0.7	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	0.9	0.4	-1.0	0.6
Delay disc. indifference point, 8s delay	0.3	0.5	0.7	0.0	-0.8	0.8
Indifference point function ln k	0.1	0.3	0.4	-0.7	-0.7	0.2
Indifference point function log k	0.1	0.3	0.4	-0.7	-0.7	0.2
Patch foraging total patch changes 0 sec	0.1	0.2	0.6	-0.1	-0.2	-0.8
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-0.6	-1.0	-0.1
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.3	-0.6	0.0
Patch foraging total patch changes 24 sec	0.5	1.7	3.3	-1.8	-1.3	0.3
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	-0.5	-0.5	-0.0
Patch foraging time to switch 0 sec	0.1	0.4	0.9	-0.1	0.9	-0.7
Patch foraging water rate 0 sec	0.5	1.7	3.1	-1.2	-1.8	0.7
Patch foraging water rate 12 sec	0.1	0.5	0.7	-0.3	-0.7	0.8
Patch foraging water rate 18 sec	0.5	1.2	1.7	-0.6	-1.2	1.3
Patch foraging water rate 24 sec	0.4	0.6	1.1	-0.5	-1.1	0.6
Patch foraging water rate 6 sec	1.4	2.1	2.7	-1.4	-1.6	1.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.2	-1.1	-0.6	-0.0
Distance traveled before self-admin	0.1	0.3	0.8	0.9	-0.0	-0.0
Distance traveled after self-admin	0.1	0.2	0.3	0.3	-0.6	0.5
Extensor digitorum longus weight	0.5	2.1	2.9	-1.2	-1.7	1.4
Bone: elastic displacement	0.3	0.4	0.6	0.3	0.8	-0.7
Bone: elastic work	0.1	0.1	0.2	-0.3	-0.2	0.4
Bone: endosteal estimation	0.4	1.0	2.8	-1.7	-0.2	-0.1
Bone: endosteal perimeter	0.6	1.4	4.1	-2.0	-0.4	0.1
Epididymis fat weight	0.2	0.9	1.2	0.9	1.1	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.6	0.2	-0.4
Delta time in open arm before/after self-admin	3.5	4.2	4.4	-2.0	-2.1	2.0
Diff in mean of infusions in LGA sessions	1.3	2.3	3.8	1.2	1.2	-2.0
Delay discount exponential model param	0.4	0.5	0.9	0.2	0.9	-0.8
Extinction: sum of active levers before priming	1.5	2.3	5.1	-2.3	-0.8	1.0
Active lever presses in extinction session 6	0.4	0.4	0.6	-0.2	0.7	-0.8
Bone: final force	1.1	1.8	1.9	-1.4	-1.4	1.3
Bone: final moment	0.9	1.4	1.6	-1.2	-1.3	1.1
Food consumed during 24 hour testing period	1.1	2.2	3.7	-1.2	-1.9	1.2
Glucose	0.6	0.9	1.4	0.3	1.1	-1.2
Heart weight	0.1	0.1	0.2	0.2	0.1	-0.5
Delay discount hyperbolic model param	0.3	0.4	0.7	0.1	0.8	-0.7
Intermittent access intake day 1-15 change	0.5	3.0	4.5	1.0	2.1	-1.8
Intermittent access intake escalation	0.6	3.2	4.7	1.3	2.2	-1.8
Intermittent access intake escalation 2	0.7	1.2	2.0	0.4	1.4	-1.2
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.1	0.2	-0.2
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.7	0.5	0.8	-0.2
Intermitt. access escalation Index	0.4	1.2	1.9	-0.6	-1.2	1.4
Intermittent access day 1 total infusions	0.0	0.0	0.0	-0.1	-0.1	-0.1
Intermittent access day 15 total infusions	0.4	1.0	1.4	0.7	1.2	-1.0
Intermittent access terminal intake (last 3 days)	0.3	0.5	0.8	0.2	0.7	-0.9
Intermittent access total infusions	0.2	0.3	0.3	0.5	0.4	-0.6
Intermittent access day 1 locomotion	0.1	0.2	0.2	0.5	0.2	-0.4
Intermittent access day 15 total locomotion	0.6	2.5	3.4	1.4	1.5	-1.8
Intermittent access total locomotion	0.6	0.8	1.1	1.1	0.7	-0.9
Intermittent access standard deviation	0.1	0.4	0.8	0.1	0.9	-0.5
Left kidney weight	0.3	2.3	4.1	-2.0	-1.3	1.0
Right kidney weight	0.4	2.7	5.2	-2.3	-1.3	1.1
Cocaine induced anxiety	1.8	5.0	5.9	2.4	2.3	-1.9
Post-drug Anxiety	1.3	1.5	3.9	2.0	0.7	-0.1
Baseline Anxiety	1.2	2.0	3.7	-0.1	-1.5	1.9
Tail length	2.8	15.0	29.6	-5.4	-3.5	1.8
Length with tail	4.0	17.9	35.4	-5.9	-3.6	2.2
Length without tail	0.6	3.0	5.3	-2.3	-1.6	1.0
Times rat made contact with spout	1.9	2.1	2.9	-1.6	-1.7	1.0
Lifetime Intake	0.3	0.3	0.5	0.7	0.6	-0.5
Liver weight, left	0.8	1.4	3.2	-1.8	-0.9	-0.0
Liver weight, right	0.5	0.9	1.7	-1.3	-1.0	0.3
Locomotor activity	1.0	1.6	2.1	-1.3	-1.5	0.9
Locomotor testing distance	0.0	0.1	0.2	-0.1	-0.4	-0.1
Locomotor testing rearing	0.0	0.1	0.2	-0.2	-0.5	0.2
Locomotion in novel chamber	0.5	0.6	1.0	1.0	0.7	-0.6
Locomotion in novel chamber post-restriction	0.1	0.3	0.5	0.7	0.6	-0.0
Fecal boli incidents, locomotor time 1	0.1	0.2	0.5	0.0	0.3	0.7
Change in fecal boli incidents, locomotor task	2.1	2.2	2.4	1.4	1.5	-1.5
Time >=10cm from walls, locomotor time 1	1.4	1.7	2.7	0.9	1.6	-1.2
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.6	-0.5	0.3
Total resting periods, locomotor time 1	0.2	0.2	0.2	-0.5	-0.3	0.5
Rest time, locomotor task time 1	0.1	0.1	0.2	0.2	0.4	0.3
Distance moved, locomotor task time 1	0.4	1.2	1.5	-1.2	-1.2	0.9
Vertical activity count, locomotor time 1	0.0	0.1	0.3	0.2	0.2	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	0.0	-0.1
Bouts of movement, locomotor time 2	0.3	0.9	1.6	0.9	0.5	-1.3
Total resting periods, locomotor time 2	0.3	1.2	2.0	0.9	0.7	-1.4
Rest time, locomotor task time 2	0.7	1.3	2.4	0.4	1.6	-1.1
Distance moved, locomotor task time 2	1.4	1.9	2.6	-1.3	-1.6	1.2
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	-0.2	0.1
Light reinforcement 1	2.5	11.5	13.4	-3.3	-3.7	3.2
Light reinforcement 2	1.6	3.5	4.3	-1.6	-2.0	2.1
Bone: marrow area	0.5	1.1	3.3	-1.8	-0.3	0.0
Bone: maximum diameter	0.7	1.4	4.1	-2.0	-0.3	-0.1
Bone: maximum force	0.2	0.3	0.6	-0.8	-0.5	0.4
Bone: maximum moment	0.1	0.1	0.3	-0.5	-0.3	0.2
Mean time between licks in bursts	0.5	3.3	4.6	1.5	2.1	-1.7
Mean num. licks in bursts	1.7	4.5	6.5	-2.6	-2.0	1.7
Cd content in liver	1.4	1.6	2.8	-1.7	-1.1	0.9
Co content in liver	2.6	3.1	5.2	-2.3	-1.3	1.5
Cu content in liver	1.2	1.4	2.2	1.5	0.9	-1.1
Fe content in liver	0.6	0.7	1.2	0.5	0.9	-1.1
K content in liver	0.1	0.1	0.4	0.6	0.0	-0.1
Mg content in liver	0.3	0.3	0.6	-0.2	-0.8	0.5
Mn content in liver	0.6	0.6	0.9	-0.8	-0.9	0.6
Na content in liver	0.0	0.0	0.1	-0.1	-0.1	-0.3
Rb content in liver	3.0	3.5	5.6	-2.4	-2.0	0.9
Se content in liver	0.1	0.1	0.2	0.1	0.1	-0.4
Sr content in liver	0.5	0.4	1.2	-1.1	0.0	0.2
Zn content in liver	0.3	0.4	0.5	0.5	0.6	-0.7
Bone: minimum diameter	1.0	1.9	5.1	-2.3	-0.7	0.3
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.3	0.2	0.0
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.2	-0.3	0.4
Total zone transitions, hab. session 1	2.7	3.7	4.9	1.9	1.7	-2.2
Total locomotion distance, hab. session 1	6.1	8.7	9.6	3.1	2.6	-3.1
Locomotion velocity, hab. session 1	4.2	6.0	7.3	2.5	2.1	-2.7
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	-0.3	-0.1
Time in novel zone, hab. session 2	0.2	0.2	0.4	0.3	-0.1	0.6
Total zone transitions, hab. session 2	1.9	2.4	3.4	1.6	1.2	-1.8
Total locomotion distance, hab. session 2	2.7	3.5	5.2	2.3	1.5	-1.8
Locomotion velocity, hab. session 2	2.8	3.7	5.0	2.2	1.6	-1.9
Novel to familiar place preference ratio	0.7	0.9	2.0	0.7	1.4	-0.4
Novelty place preference	0.7	0.9	2.3	0.4	1.5	-0.5
Time in novel zone, NPP test	0.8	0.9	2.2	0.6	1.5	-0.6
Total zone transitions, NPP test	2.5	3.8	5.4	2.3	1.4	-2.0
Total locomotion distance, NPP test	0.9	1.3	2.3	1.5	0.5	-1.2
Locomotion velocity, NPP test	0.6	0.9	1.5	1.2	0.4	-1.0
Intraocular pressure	0.6	1.0	1.4	1.1	0.7	-1.2
Delta distance traveled before/after self-admin	1.6	1.7	1.9	-1.2	-1.3	1.4
Delta ambulatory time before/after self-admin	0.8	1.3	1.5	-1.2	-1.2	1.1
Parametrial fat weight	0.0	0.1	0.1	0.2	0.4	-0.3
Pavlov. Cond. lever latency	0.7	0.9	1.1	-0.9	-0.8	1.1
Pavlov. Cond. magazine entry latency	2.0	2.5	4.1	1.1	1.5	-2.0
Pavlov. Cond. change in total contacts	2.9	3.1	4.1	1.6	1.6	-2.0
Pavlov. Cond. index score	1.2	1.5	2.3	0.9	1.2	-1.5
Pavlov. Cond. latency score	0.8	1.0	1.7	0.6	0.9	-1.3
Pavlov. Cond. lever contacts	0.9	1.1	1.4	0.9	1.1	-1.2
Pavlov. Cond. magazine entry number	3.4	4.3	6.2	-1.8	-1.8	2.5
Pavlov. Cond. intertrial magazine entries	4.3	5.2	7.4	-1.5	-2.4	2.7
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.7	1.2	1.3	-1.7
Pavlov. Cond. response bias	2.7	3.3	4.6	1.7	1.6	-2.1
Pavlov. Cond. lever latency	0.3	0.4	0.6	0.5	0.8	-0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.4	-0.5	0.2
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	0.3	-0.5	0.5
Pavlov. Cond. index score	0.1	0.2	0.4	0.1	-0.6	0.4
Pavlov. Cond. latency score	0.1	0.2	0.5	-0.0	-0.7	0.5
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.5	-0.8	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.6	0.0	0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.8	1.0	-1.0	-0.9	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.3	0.2	-0.6	0.4
Pavlov. Cond. response bias	0.0	0.0	0.1	0.1	-0.3	0.1
Time in closed arm before self-admin	0.4	0.8	2.2	1.5	0.1	-0.4
Time in closed arm after self-admin	1.9	2.1	2.4	1.6	1.3	-1.5
Time in open arm before self-admin	0.3	0.3	0.6	0.4	0.8	-0.5
Time in open arm after self-admin	5.9	6.5	7.7	-2.8	-2.5	2.3
Bone: periosteal estimation	0.6	1.5	4.2	-2.0	-0.6	0.2
Bone: periosteal perimeter	1.2	2.4	6.1	-2.5	-1.0	0.4
Bone: post-yield work	0.3	0.5	1.1	0.1	0.7	-1.0
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	-0.1	-0.0	-0.0
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.2	-0.0	-0.0
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.4	0.2	0.7	-0.6
Progressive ratio test 2 active lever presses	0.3	0.4	0.7	0.8	0.3	-0.6
Progressive ratio test 2 breakpoint	0.3	0.4	0.8	0.9	0.2	-0.5
Progressive ratio test 2 inactive lever presses	0.4	1.1	1.6	0.7	1.2	-1.3
Incentive Sensitization - Responses	0.1	0.4	1.2	1.1	-0.2	-0.0
Incentive Sensitization - Breakpoint	0.2	0.4	1.2	1.1	-0.3	-0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.7	-0.3	0.5
Progressive ratio	0.0	0.1	0.2	0.1	-0.1	0.4
Food seeking constrained by brief footshock	1.0	1.3	3.1	1.8	0.3	-0.7
Seeking ratio, punishment vs. effort	0.1	0.3	0.5	0.7	-0.1	-0.6
Retroperitoneal fat weight	1.2	5.2	7.2	1.7	2.4	-2.7
Reaction time number correct	0.7	2.6	4.4	2.1	1.5	-1.1
Reaction time mean minus median	0.4	2.8	3.7	1.4	1.6	-1.9
Reaction time mean minus median AUC	0.4	2.9	3.5	1.7	1.6	-1.9
Reaction time num false alarms	0.6	1.0	2.7	1.7	0.3	-0.3
Reaction time num false alarms AUC	0.6	1.4	3.9	2.0	0.4	-0.4
Reaction time trials correct on left	0.7	2.6	4.4	2.1	1.5	-1.1
Reaction time trials on left	0.9	3.1	5.2	2.3	1.6	-1.2
Reaction time mean	0.6	1.4	2.2	1.5	1.0	-0.9
Reaction time mean AUC	0.7	1.6	2.5	1.6	1.2	-1.0
Median of all reaction times	0.5	0.7	1.6	1.3	0.7	-0.3
Reaction time omissions	4.3	7.0	8.2	2.9	2.5	-2.5
Reaction time false alarm rate	0.2	0.3	0.6	0.7	-0.5	0.3
Reaction time premature initiation rate	1.1	1.6	3.9	-0.4	0.9	-2.0
Reaction time premature initiations	0.9	2.8	5.4	0.6	1.6	-2.3
Std. dev. reaction times	1.2	4.1	5.1	2.3	1.9	-1.9
Reaction time trials completed	0.9	3.1	5.2	2.3	1.6	-1.2
Reaction time trials AUC	0.8	2.9	4.9	2.2	1.5	-1.2
Run reversals in cocaine runway, females	0.6	0.7	0.9	-0.9	-0.7	0.9
Run reversals in cocaine runway, males	0.4	0.4	0.8	0.7	0.1	-0.9
Latency to leave start box in cocaine runway	0.3	0.5	0.7	0.8	0.7	-0.5
Latency to leave start box in cocaine runway, F	0.0	0.0	0.0	0.0	-0.0	0.2
Latency to leave start box in cocaine runway, M	1.6	1.5	1.9	1.4	1.3	-1.0
Std. dev. time between licks in bursts	1.2	2.3	3.2	1.8	1.6	-1.0
Total sessions with >9 infusions	0.0	0.0	0.1	0.2	0.2	-0.1
Short access day 1 total inactive lever presses	0.2	0.3	0.7	-0.0	0.9	-0.5
Short access day 10 total inactive lever presses	0.1	0.4	0.6	0.8	0.7	-0.2
Short access day 1 total infusions	0.1	0.2	0.2	-0.4	-0.4	0.4
Short access day 10 total infusions	0.1	0.1	0.2	0.3	0.4	-0.3
Short access total infusions	0.2	0.3	0.4	0.6	0.7	-0.4
Short access day 1 locomotion	0.3	0.5	1.1	0.3	1.0	-0.7
Short access day 10 total locomotion	0.1	0.5	0.8	0.4	0.8	-0.9
Short access total locomotion	0.3	0.5	0.7	0.5	0.8	-0.7
One hour access (0.3 mA shock)	0.5	0.6	1.2	-1.1	-0.4	0.7
Compulsive drug intake	1.7	2.6	3.9	-1.1	-1.6	2.0
One hour access (shock baseline)	0.1	0.4	0.7	-0.2	0.8	-0.6
Social response proportion	0.2	0.2	0.3	-0.4	-0.4	0.6
Social responses	0.3	0.4	0.9	-0.4	-0.5	1.0
Social time	0.6	0.9	1.7	-0.4	-1.0	1.3
Soleus weight	3.0	9.0	12.0	-2.8	-3.5	2.7
Bone: stiffness	0.1	0.2	0.4	0.1	0.6	-0.4
Tibialis anterior weight	1.9	6.4	8.8	-2.1	-3.0	2.4
Time to tail flick, vehicle, before self-admin	1.8	2.2	2.7	1.6	1.2	-1.6
Time to tail flick, vehicle, after self-admin	1.8	3.6	4.1	1.6	2.0	-2.0
Time to tail flick, test, before self-admin	1.1	1.2	1.5	1.0	1.1	-1.2
Time to tail flick, test, after self-admin	0.1	0.1	0.3	0.5	0.2	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	-0.6	-0.1	0.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.0	-0.4	0.7
Tibia length	0.3	0.9	2.0	-1.4	-0.3	0.7
Ambulatory time before self-admin	0.1	0.4	1.0	1.0	0.1	-0.0
Ambulatory time after self-admin	0.3	0.4	0.9	0.2	-0.9	0.6
Bone: tissue strength	0.7	0.7	1.2	1.1	0.2	-1.0
Total heroin consumption	0.3	0.3	0.6	0.2	0.6	-0.8
Bone: trabecular number	0.1	0.2	0.3	0.3	0.1	-0.6
Bone: trabecular spacing	1.7	2.5	4.0	-1.1	-1.4	2.0
Bone: trabecular thickness	0.4	0.6	1.0	0.2	0.8	-1.0
Bone: trabecular tissue density	1.2	2.1	2.7	-1.4	-1.3	1.6
Water consumed over 24 hours	1.0	1.8	3.5	-1.3	-1.9	0.6
Number of responses in last shaping day	0.2	0.3	0.9	-0.9	-0.2	-0.1