Hub : Genes

Actn2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Actn2 0.14 0.07 5.5e-10 0.06 0.09 0.08 0.08 1.7e-05 2.3e-07 9.1e-07 3.9e-07
2 PL gene expression Actn2 0.09 0.05 3.9e-06 0.04 0.05 0.05 0.05 1.6e-05 7.5e-06 5.9e-06 4.1e-06
3 Liver gene expression Actn2 0.18 0.08 0.0e+00 0.16 0.19 0.18 0.18 5.8e-18 2.9e-20 3.7e-20 5.4e-20
4 Brain gene expression Actn2 0.19 0.09 6.7e-11 0.11 0.12 0.14 0.12 9.6e-11 1.9e-11 5.2e-13 9.7e-12
5 BLA gene expression Actn2 0.13 0.07 3.2e-04 0.05 0.05 0.03 0.04 1.1e-03 7.9e-04 1.4e-02 3.5e-03
6 Brain mRNA stability Actn2 0.05 0.03 4.5e-06 0.07 0.05 0.07 0.07 1.6e-07 1.7e-05 8.3e-07 2.8e-07
7 IC gene expression Actn2 0.17 0.09 2.8e-04 0.08 0.06 0.05 0.07 2.3e-04 1.2e-03 3.5e-03 5.0e-04
8 NAcc gene expression Actn2 0.1 0.05 2.5e-14 0.1 0.1 0.09 0.1 8.5e-15 3.0e-14 2.6e-13 2.5e-14
9 NAcc mRNA stability Actn2 0.04 0.02 8.5e-06 0.03 0.03 0.04 0.03 9.3e-06 7.9e-06 3.3e-06 5.8e-06
10 pVTA mRNA stability Actn2 0.1 0.05 6.5e-07 0.09 0.09 0.09 0.1 7.7e-08 7.9e-08 8.4e-08 2.3e-08
11 Adipose gene expression Actn2 0.07 0.04 4.7e-06 0.05 0.04 0.05 0.05 1.6e-06 1.5e-05 2.1e-06 4.4e-06
12 PL mRNA stability Actn2 0.14 0.07 3.0e-10 0.1 0.08 0.1 0.1 2.9e-11 4.8e-09 1.6e-10 7.2e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.30.60.50.70.4-0.10.6-0.00.80.40.2-0.30.7-0.7
Area under the delay curve0.30.41.2-0.4-0.9-0.3-1.1-0.70.4-0.70.10.00.5-0.70.7
BMI with tail0.10.21.00.40.50.20.71.0-0.30.30.2-0.2-0.40.4-0.5
BMI without tail0.30.92.2-1.2-0.8-1.2-0.1-0.4-1.2-0.5-1.5-1.3-0.90.4-0.6
Body weight1.98.217.4-4.1-3.8-4.2-2.4-2.6-3.4-3.1-3.1-2.2-0.7-0.80.7
Weight adjusted by age0.20.30.80.50.40.30.30.60.60.10.90.80.1-0.60.6
Bone surface1.22.34.3-2.1-1.8-2.1-1.7-1.8-2.0-1.3-1.5-1.0-0.2-0.40.4
Bone volume0.81.52.7-1.7-1.4-1.6-1.3-1.5-1.6-0.9-1.3-1.0-0.3-0.10.0
Breakpoint value in progressive ratio session0.10.20.40.50.50.30.20.60.30.00.70.40.2-0.20.2
Number of licking bursts0.60.92.00.5-0.10.5-1.2-0.20.3-0.51.31.41.2-1.41.4
Context. condit. distance diff. score1.41.73.51.31.71.21.91.60.71.60.4-0.3-1.11.3-1.3
Locomotion velocity, session 10.91.02.61.20.51.20.11.01.10.41.61.41.0-0.50.5
Locomotion distance, session 12.63.36.61.5-0.21.8-0.80.12.2-0.92.62.52.4-2.22.1
Locomotion velocity, session 21.01.13.60.81.10.61.81.90.31.20.5-0.1-0.71.0-1.1
Locomotion distance, session 21.41.95.02.01.31.90.51.31.50.62.21.70.9-0.50.5
Locomotion velocity, session 31.31.54.01.11.40.92.01.81.01.00.4-0.4-0.91.3-1.3
Locomotion distance, session 33.84.19.31.12.20.83.02.40.52.4-0.2-1.4-2.22.7-2.8
Stereotopy head waving bouts, day 31.21.43.0-1.5-0.7-1.70.3-0.0-1.7-0.2-1.7-1.5-1.20.9-0.8
Stereotopy head waving duration, day 30.80.92.4-1.4-1.2-1.5-0.2-0.4-1.4-0.7-1.2-0.8-0.4-0.00.1
Locomotion velocity, session 70.60.71.9-0.10.1-0.11.41.10.60.8-0.6-0.9-0.71.1-1.1
Locomotion distance, session 71.51.93.61.71.71.61.91.71.01.81.00.3-0.60.9-1.0
Stereotopy head waving bouts, day 70.91.02.6-1.5-1.3-1.6-0.8-0.8-1.2-1.0-1.2-0.7-0.0-0.20.2
Stereotopy head waving duration, day 72.22.65.4-1.9-2.2-1.8-2.0-2.0-0.9-2.3-1.1-0.10.9-1.31.3
Locomotion velocity, session 80.20.20.70.60.50.50.70.80.7-0.00.50.40.20.0-0.1
Locomotion distance, session 80.71.02.11.40.71.50.80.91.40.41.41.20.7-0.50.4
Degree of sensitization distance0.90.92.30.6-0.20.8-0.6-0.50.2-0.41.11.31.1-1.51.5
Degree of sensitization stereotypy1.31.42.4-1.5-1.6-1.5-1.4-1.4-1.1-1.4-1.0-0.30.4-0.80.8
Conditioned locomotion0.10.10.20.20.10.2-0.2-0.1-0.50.20.40.30.3-0.40.3
Cocaine response after cond. corrected0.40.51.21.11.01.00.60.90.50.41.10.6-0.10.1-0.1
Cocaine response after cond. not corrected0.00.00.20.10.00.10.10.1-0.1-0.40.10.0-0.20.1-0.0
Cocaine response before conditioning1.92.24.8-2.1-2.2-1.9-1.4-1.8-0.9-1.8-1.8-1.00.1-0.30.5
Saline control response2.12.86.0-2.4-2.2-2.2-1.5-2.1-1.0-1.3-2.3-1.6-0.2-0.10.0
Bone: connectivity density0.10.10.30.40.60.3-0.30.2-0.20.40.40.5-0.10.2-0.3
Bone: cortical apparent density0.91.22.9-1.1-1.6-0.9-1.7-1.4-0.5-1.5-0.60.10.8-1.01.0
Bone: cortical area1.01.64.1-0.9-1.6-0.6-1.5-1.6-0.2-2.0-0.10.41.3-1.51.5
Bone: cortical porosity0.30.41.8-0.7-0.4-0.9-0.5-0.4-1.4-0.5-0.4-0.3-0.2-0.10.1
Bone: cortical porosity0.20.31.4-0.5-0.3-0.7-0.4-0.4-1.2-0.5-0.1-0.1-0.1-0.30.3
Bone: cortical thickness0.20.40.90.5-0.10.6-0.30.00.4-0.80.80.91.0-0.60.6
Bone: cortical thickness0.10.10.3-0.20.1-0.20.10.2-0.5-0.5-0.3-0.1-0.10.2-0.3
Bone: cortical tissue density0.81.12.6-1.1-1.5-0.9-1.6-1.3-0.5-1.4-0.60.10.7-0.91.0
Condit. Reinf. active minus inactive responses0.60.71.9-0.30.5-0.60.30.5-1.40.7-0.4-0.8-1.31.1-1.0
Condit. Reinf. active-inactive response ratio0.40.41.20.10.7-0.10.30.3-1.10.7-0.0-0.3-1.00.9-0.8
Condit. Reinf. active responses1.11.33.8-1.5-0.7-1.7-0.4-0.2-1.9-0.1-1.4-1.5-1.30.6-0.6
Condit. Reinf. inactive responses1.11.33.2-1.8-1.6-1.8-0.7-0.7-1.0-0.8-1.5-1.4-0.4-0.30.2
Incentive salience index mean0.60.72.5-0.80.0-1.1-0.10.1-1.60.0-0.7-1.0-1.10.8-0.8
Condit. Reinf. lever presses0.40.61.6-1.1-0.7-1.3-0.9-0.4-1.1-1.1-0.6-0.6-0.2-0.20.2
Condit. Reinf. active minus inactive responses0.10.10.9-0.00.2-0.30.30.6-0.90.00.3-0.0-0.3-0.1-0.0
Condit. Reinf. active-inactive response ratio0.20.20.80.40.30.2-0.00.5-0.60.10.90.70.2-0.60.6
Condit. Reinf. active responses0.40.62.0-0.9-0.3-1.10.20.1-1.4-0.3-0.8-1.0-0.90.6-0.6
Condit. Reinf. inactive responses0.81.02.2-1.1-0.4-1.20.2-0.3-1.1-0.2-1.4-1.5-1.21.1-1.1
Condit. Reinf. lever presses0.40.61.21.01.10.90.51.00.90.90.70.3-0.30.6-0.6
Condit. Reinf. lever reinforcers received0.30.41.0-0.7-0.2-0.9-0.0-0.0-1.0-0.3-0.6-0.8-0.70.5-0.5
Conditioned reinforcement - actives0.40.61.40.41.00.11.10.8-0.41.20.0-0.5-1.01.0-1.0
Conditioned reinforcement - inactives0.20.20.50.2-0.10.3-0.5-0.40.4-0.20.50.50.7-0.70.7
Conditioned locomotion0.81.03.41.01.30.91.81.20.31.30.4-0.1-0.70.8-0.8
Patch foraging indifference point 0 sec0.50.92.11.01.21.01.41.21.30.90.5-0.1-0.50.7-0.8
Patch foraging indifference point AUC1.31.93.8-1.1-1.9-0.9-1.9-1.8-0.3-1.7-0.30.41.4-1.51.6
Delay disc. indifference point, 0s delay0.40.40.8-0.2-0.8-0.0-0.6-0.90.6-0.60.40.30.7-0.90.9
Delay disc. indifference point, 16s delay0.70.72.2-0.60.0-0.60.30.2-0.60.8-0.9-1.5-1.01.1-1.2
Delay disc. indifference point, 2s delay0.40.40.80.2-0.40.3-0.7-0.60.9-0.60.70.60.6-0.80.8
Delay disc. indifference point, 24s delay0.20.20.50.00.3-0.00.30.60.40.6-0.2-0.6-0.50.7-0.7
Delay disc. indifference point, 4s delay1.71.83.70.7-0.20.7-1.1-0.71.6-1.01.71.71.4-1.91.9
Delay disc. indifference point, 8s delay0.50.61.9-1.0-1.4-0.9-1.1-0.8-0.3-0.8-0.5-0.30.4-0.60.6
Indifference point function ln k0.51.02.31.11.51.01.41.20.41.00.7-0.1-0.60.9-0.9
Indifference point function log k0.51.02.31.11.51.01.41.20.41.00.7-0.1-0.60.9-0.9
Patch foraging total patch changes 0 sec0.40.81.70.91.10.91.31.11.30.70.3-0.2-0.40.7-0.7
Patch foraging total patch changes 12 sec0.10.20.80.3-0.00.40.10.30.9-0.10.40.40.5-0.40.4
Patch foraging total patch changes 18 sec0.40.61.5-0.3-0.8-0.0-1.2-0.90.6-0.80.00.61.0-0.90.9
Patch foraging total patch changes 24 sec0.20.31.0-0.8-0.7-0.6-0.2-0.40.1-0.3-1.0-0.7-0.20.2-0.3
Patch foraging total patch changes 6 sec0.40.61.40.5-0.20.7-0.30.01.2-0.31.00.91.1-1.01.0
Patch foraging time to switch 0 sec0.30.71.5-0.9-0.2-1.20.00.2-1.20.1-1.1-0.8-1.00.8-0.9
Patch foraging water rate 0 sec0.20.41.0-0.1-0.70.0-0.4-0.70.2-0.90.20.20.7-1.00.9
Patch foraging water rate 12 sec0.81.63.70.6-0.40.9-0.9-0.61.2-1.11.41.61.6-1.91.8
Patch foraging water rate 18 sec0.20.31.3-0.10.4-0.30.70.4-1.10.1-0.3-0.6-0.80.4-0.5
Patch foraging water rate 24 sec1.21.73.8-0.6-1.5-0.3-1.4-1.40.2-1.90.20.71.5-1.91.8
Patch foraging water rate 6 sec0.60.91.9-1.0-1.4-0.9-0.7-1.2-0.3-1.3-0.6-0.30.4-1.11.0
Seeking ratio, delayed vs. immediate footshock0.20.20.80.00.2-0.30.80.9-0.10.5-0.0-0.2-0.60.4-0.4
Distance traveled before self-admin0.70.92.91.11.40.71.31.70.11.20.80.4-0.50.2-0.2
Distance traveled after self-admin2.32.96.42.12.51.72.22.50.62.41.30.6-0.70.9-0.8
Extensor digitorum longus weight0.31.13.0-1.4-1.1-1.5-0.1-0.8-1.7-0.7-1.4-1.2-0.60.2-0.2
Bone: elastic displacement1.41.63.8-0.4-1.2-0.3-2.0-0.9-0.3-1.60.51.31.7-1.71.6
Bone: elastic work1.51.94.4-0.1-1.20.2-2.0-1.10.6-1.80.61.42.1-1.81.7
Bone: endosteal estimation1.53.26.6-2.6-2.3-2.5-1.2-2.1-1.9-1.5-2.1-1.7-0.5-0.40.4
Bone: endosteal perimeter1.63.47.8-2.4-2.8-2.1-1.5-2.8-1.6-1.9-1.7-1.20.1-1.21.3
Epididymis fat weight0.93.26.9-2.5-2.0-2.6-2.1-1.6-2.4-1.4-1.9-1.2-0.7-0.20.1
Delta time in closed arm before/after self-admin0.10.10.20.30.30.2-0.10.00.2-0.20.30.5-0.1-0.30.3
Delta time in open arm before/after self-admin1.11.12.9-1.3-1.5-0.8-1.3-1.7-0.5-1.2-1.2-0.90.4-0.10.0
Diff in mean of infusions in LGA sessions0.20.31.20.50.50.50.20.71.10.20.50.50.4-0.10.1
Delay discount exponential model param0.50.61.70.40.90.31.30.8-0.50.9-0.2-0.2-0.70.9-0.9
Extinction: sum of active levers before priming0.60.71.8-0.3-0.7-0.3-1.1-0.60.5-1.30.30.80.7-1.11.1
Active lever presses in extinction session 60.10.10.20.30.30.30.30.30.40.30.20.0-0.30.3-0.2
Bone: final force0.50.81.6-0.5-1.3-0.1-1.1-1.21.0-1.1-0.3-0.01.2-0.70.7
Bone: final moment0.40.71.6-0.6-1.3-0.2-1.1-1.10.7-1.1-0.4-0.11.1-0.60.6
Food consumed during 24 hour testing period1.21.64.01.81.41.90.31.32.00.51.61.30.8-0.20.1
Glucose0.10.20.50.2-0.40.30.3-0.00.2-0.70.20.20.2-0.70.6
Heart weight0.60.92.01.31.01.20.21.21.10.21.41.20.5-0.50.4
Delay discount hyperbolic model param0.60.61.70.30.90.21.30.8-0.61.0-0.4-0.4-0.71.0-1.0
Intermittent access intake day 1-15 change0.20.40.80.80.50.70.30.60.90.20.80.80.4-0.40.4
Intermittent access intake escalation0.10.20.50.50.20.50.10.40.70.00.60.60.3-0.40.4
Intermittent access intake escalation 20.00.10.20.20.10.20.10.10.3-0.00.30.40.0-0.30.2
Intermitt. access day 1 inactive lever presses0.52.04.01.40.21.80.1-0.12.0-0.51.61.62.0-1.61.6
Intermitt. access day 15 inactive lever presses0.20.41.10.40.50.61.10.50.80.6-0.2-0.6-0.20.7-0.7
Intermitt. access escalation Index0.00.10.2-0.2-0.2-0.2-0.5-0.4-0.4-0.3-0.2-0.1-0.1-0.20.1
Intermittent access day 1 total infusions1.01.73.41.71.81.51.61.60.81.61.50.9-0.20.4-0.4
Intermittent access day 15 total infusions1.01.53.01.71.41.61.21.41.20.91.71.40.4-0.30.3
Intermittent access terminal intake (last 3 days)0.70.91.71.31.21.11.21.10.80.81.31.0-0.0-0.10.0
Intermittent access total infusions1.11.33.21.41.61.21.81.50.61.41.10.6-0.40.4-0.5
Intermittent access day 1 locomotion2.43.15.92.42.32.32.12.01.81.91.81.1-0.00.5-0.5
Intermittent access day 15 total locomotion2.03.66.82.62.62.42.32.32.11.91.91.2-0.20.5-0.6
Intermittent access total locomotion3.13.77.62.52.62.32.82.41.92.21.60.8-0.40.9-0.9
Intermittent access standard deviation0.20.50.91.00.80.90.80.70.90.50.80.80.1-0.20.1
Left kidney weight0.73.37.1-2.1-1.2-2.30.7-0.2-2.50.3-2.5-2.7-2.01.4-1.4
Right kidney weight0.31.32.8-1.5-1.0-1.7-0.2-0.1-1.7-0.3-1.5-1.5-1.00.6-0.5
Cocaine induced anxiety0.20.30.70.50.90.30.80.6-0.30.70.50.1-0.60.4-0.4
Post-drug Anxiety0.50.51.2-0.9-0.4-1.1-0.3-0.5-1.1-0.2-0.8-0.8-0.90.5-0.5
Baseline Anxiety0.60.71.5-1.2-1.2-1.1-1.0-0.9-0.3-1.0-1.1-0.70.0-0.00.0
Tail length2.610.221.7-4.6-4.0-4.7-2.5-3.3-3.9-2.7-3.9-2.7-1.2-0.40.3
Length with tail4.118.038.5-6.1-5.5-6.2-3.8-4.4-4.8-4.0-4.9-3.2-1.1-0.90.8
Length without tail2.16.814.7-3.7-3.2-3.8-2.4-2.4-3.4-2.7-2.8-1.9-0.7-0.30.3
Times rat made contact with spout0.00.00.30.00.10.10.30.20.60.0-0.1-0.10.0-0.0-0.1
Lifetime Intake1.72.04.81.72.01.32.21.90.41.91.20.4-0.80.9-0.9
Liver weight, left1.52.64.9-1.7-2.2-1.5-2.2-2.2-0.8-2.2-0.8-0.20.9-1.31.4
Liver weight, right1.83.26.6-1.5-2.6-1.1-2.1-2.30.3-2.4-0.40.41.7-2.12.2
Locomotor activity0.40.61.41.10.81.20.70.71.10.60.80.60.2-0.0-0.1
Locomotor testing distance0.30.51.20.90.80.90.90.81.10.70.50.2-0.10.5-0.5
Locomotor testing rearing0.30.51.20.20.50.11.10.90.60.7-0.3-0.5-0.71.0-1.0
Locomotion in novel chamber0.00.10.30.1-0.20.10.10.20.20.00.20.20.4-0.50.4
Locomotion in novel chamber post-restriction0.10.10.3-0.4-0.5-0.40.20.2-0.30.1-0.6-0.5-0.20.3-0.2
Fecal boli incidents, locomotor time 10.10.10.4-0.1-0.3-0.0-0.7-0.50.2-0.50.10.30.4-0.40.5
Change in fecal boli incidents, locomotor task0.20.20.50.0-0.40.3-0.6-0.50.4-0.60.00.30.7-0.50.4
Time >=10cm from walls, locomotor time 10.30.30.5-0.7-0.6-0.5-0.7-0.6-0.5-0.4-0.7-0.5-0.10.3-0.3
Bouts of movement, locomotor time 11.11.23.30.11.0-0.41.41.1-0.81.5-0.2-0.9-1.81.3-1.4
Total resting periods, locomotor time 11.01.12.90.00.8-0.41.41.0-0.81.4-0.3-1.0-1.71.3-1.4
Rest time, locomotor task time 10.20.20.90.30.70.10.60.1-0.90.60.4-0.0-0.60.2-0.1
Distance moved, locomotor task time 10.10.20.4-0.2-0.2-0.1-0.10.40.60.1-0.6-0.40.20.5-0.7
Vertical activity count, locomotor time 10.81.94.90.61.30.41.61.80.51.9-0.5-0.9-1.32.0-2.2
Time >=10cm from walls, locomotor time 20.20.31.00.80.61.00.80.20.40.10.60.60.4-0.20.3
Bouts of movement, locomotor time 21.11.84.7-0.90.2-1.41.10.5-1.90.8-1.0-1.7-2.21.5-1.6
Total resting periods, locomotor time 21.12.04.7-1.1-0.1-1.60.80.3-2.00.8-1.2-1.9-2.21.6-1.6
Rest time, locomotor task time 20.91.13.0-1.5-1.7-1.5-1.0-1.2-0.9-0.6-0.9-0.9-0.1-0.20.2
Distance moved, locomotor task time 20.40.51.10.61.00.51.01.10.10.8-0.1-0.1-0.40.7-0.9
Vertical activity count, locomotor time 22.23.05.81.22.20.82.12.4-0.62.4-0.2-0.7-1.72.1-2.3
Light reinforcement 10.61.53.0-0.40.3-0.51.30.7-0.41.4-1.4-1.7-1.51.7-1.7
Light reinforcement 21.32.05.70.51.20.42.01.60.32.4-0.5-1.0-1.41.9-1.7
Bone: marrow area1.43.06.3-2.5-2.2-2.4-1.1-2.0-2.0-1.4-2.1-1.7-0.6-0.30.3
Bone: maximum diameter1.93.66.9-2.2-2.6-1.9-2.3-2.5-1.4-2.6-1.0-0.41.0-1.71.7
Bone: maximum force0.40.71.5-0.5-1.2-0.1-1.0-1.10.8-1.0-0.20.11.2-0.80.8
Bone: maximum moment0.40.61.3-0.6-1.1-0.2-1.0-1.10.5-1.1-0.30.11.1-0.70.7
Mean time between licks in bursts0.30.93.3-0.9-0.2-1.20.20.0-1.80.2-1.0-1.0-1.30.6-0.7
Mean num. licks in bursts0.91.32.8-0.40.5-0.41.70.6-0.20.9-1.2-1.6-1.41.6-1.7
Cd content in liver2.32.65.92.31.42.30.51.21.91.12.42.01.1-0.70.7
Co content in liver1.51.73.91.40.91.5-1.10.21.6-0.61.82.01.7-1.00.8
Cu content in liver0.50.62.1-0.9-0.4-1.1-0.3-0.3-1.50.2-1.0-0.9-0.70.4-0.5
Fe content in liver0.70.83.3-0.70.1-1.10.00.2-1.80.3-0.9-1.0-1.20.8-1.0
K content in liver1.31.22.9-1.7-1.3-1.7-1.1-0.9-1.3-1.3-1.2-0.8-0.0-0.10.2
Mg content in liver1.61.63.3-1.8-1.3-1.8-1.5-1.4-1.6-1.4-1.3-0.7-0.0-0.30.3
Mn content in liver2.22.44.8-2.0-1.1-2.1-0.2-1.1-2.1-0.4-2.2-2.1-1.41.0-1.0
Na content in liver0.10.10.2-0.20.1-0.20.4-0.10.20.4-0.4-0.4-0.30.4-0.5
Rb content in liver0.70.82.2-0.8-1.1-0.8-1.5-1.0-0.6-1.4-0.10.20.6-0.80.8
Se content in liver1.61.95.1-1.6-0.7-2.00.5-0.1-2.30.3-1.7-1.8-1.50.9-1.0
Sr content in liver0.50.40.80.50.80.30.70.90.10.90.1-0.2-0.60.8-0.8
Zn content in liver0.20.30.7-0.20.3-0.50.20.6-0.80.2-0.3-0.5-0.60.6-0.7
Bone: minimum diameter0.50.92.1-0.5-1.1-0.3-0.9-1.4-0.3-1.20.30.50.9-1.51.4
Time in familiar zone, hab. session 10.50.51.4-0.6-0.3-0.70.6-0.0-1.0-0.1-0.7-1.2-1.00.6-0.7
Time in novel zone, hab. session 10.40.41.10.50.30.7-0.7-0.20.80.10.61.10.9-0.50.5
Total zone transitions, hab. session 12.63.66.90.8-1.01.2-1.6-1.51.5-2.01.82.22.6-2.62.6
Total locomotion distance, hab. session 10.30.51.00.3-0.40.3-0.7-0.5-0.1-0.50.91.00.7-1.00.9
Locomotion velocity, hab. session 10.50.61.60.1-0.60.2-0.7-0.5-0.2-0.71.01.00.9-1.31.2
Time in familiar zone, hab. session 20.50.51.50.90.80.91.00.71.20.60.5-0.1-0.10.4-0.4
Time in novel zone, hab. session 20.20.21.00.40.40.3-0.30.2-0.4-0.00.71.00.4-0.40.4
Total zone transitions, hab. session 20.81.12.50.6-0.40.9-0.3-0.41.1-0.81.21.11.4-1.51.6
Total locomotion distance, hab. session 20.30.41.2-0.4-0.0-0.60.70.1-1.10.4-0.6-0.9-1.10.6-0.5
Locomotion velocity, hab. session 20.30.41.4-0.7-0.4-0.80.4-0.1-1.20.2-0.7-0.9-0.90.3-0.3
Novel to familiar place preference ratio0.10.10.5-0.1-0.20.1-0.6-0.70.6-0.2-0.10.10.5-0.10.2
Novelty place preference0.10.10.40.0-0.00.2-0.6-0.60.6-0.20.10.30.6-0.20.2
Time in novel zone, NPP test0.10.10.4-0.0-0.00.2-0.7-0.60.5-0.20.00.20.5-0.10.1
Total zone transitions, NPP test0.10.10.30.1-0.30.3-0.4-0.50.1-0.60.40.20.3-0.50.4
Total locomotion distance, NPP test0.20.31.2-0.5-0.1-0.60.2-0.1-1.10.2-0.6-0.7-0.90.4-0.5
Locomotion velocity, NPP test0.20.20.9-0.5-0.5-0.6-0.1-0.5-0.9-0.3-0.3-0.4-0.5-0.10.1
Intraocular pressure0.71.01.90.6-0.10.8-0.2-0.11.4-0.91.11.11.4-1.41.3
Delta distance traveled before/after self-admin0.10.10.30.30.20.50.20.10.40.5-0.0-0.00.10.3-0.3
Delta ambulatory time before/after self-admin0.10.10.30.20.10.40.3-0.00.10.6-0.3-0.4-0.20.6-0.6
Parametrial fat weight0.20.41.4-0.40.1-0.80.50.7-1.20.4-0.5-0.5-0.90.6-0.6
Pavlov. Cond. lever latency0.70.83.30.90.31.2-0.10.21.80.80.91.21.1-0.30.3
Pavlov. Cond. magazine entry latency0.91.13.0-1.1-0.4-1.30.1-0.5-1.7-0.1-1.2-1.6-1.50.7-0.7
Pavlov. Cond. change in total contacts0.91.04.8-0.50.3-0.90.40.3-2.20.3-0.6-1.0-1.60.7-0.7
Pavlov. Cond. index score0.70.92.6-0.9-0.2-1.10.3-0.2-1.6-0.3-0.9-1.4-1.40.6-0.6
Pavlov. Cond. latency score0.81.03.4-1.1-0.4-1.30.2-0.3-1.8-0.5-1.1-1.5-1.40.5-0.5
Pavlov. Cond. lever contacts0.50.62.4-0.8-0.4-1.0-0.4-0.2-1.6-1.0-0.5-0.7-0.70.0-0.0
Pavlov. Cond. magazine entry number0.81.02.90.6-0.10.8-0.7-0.11.3-0.31.01.61.7-1.11.0
Pavlov. Cond. intertrial magazine entries1.01.22.70.7-0.20.7-0.60.10.7-0.71.61.71.4-1.51.5
Pavlov. Cond. lever-magazine prob. diff.0.60.72.2-0.6-0.0-0.90.40.0-1.5-0.1-0.8-1.3-1.40.7-0.6
Pavlov. Cond. response bias0.50.62.3-0.7-0.2-0.9-0.1-0.3-1.5-0.4-0.8-1.1-1.20.5-0.4
Pavlov. Cond. lever latency0.20.31.5-0.6-0.5-0.6-0.3-0.9-1.2-0.5-0.4-0.3-0.0-0.30.3
Pavlov. Cond. magazine entry latency0.10.11.00.20.10.4-0.3-0.11.00.20.20.40.4-0.00.1
Pavlov. Cond. change in total contacts0.10.20.90.30.30.30.00.41.00.50.20.10.10.3-0.3
Pavlov. Cond. index score0.10.10.70.40.20.4-0.10.50.80.30.40.40.20.00.0
Pavlov. Cond. latency score0.10.10.60.20.20.2-0.10.40.80.40.20.20.10.2-0.1
Pavlov. Cond. lever contacts0.40.62.70.90.61.00.30.91.60.50.70.60.30.1-0.1
Pavlov. Cond. magazine entry number0.20.20.7-0.10.3-0.30.50.2-0.8-0.1-0.4-0.6-0.80.5-0.6
Pavlov. Cond. intertrial magazine entries0.00.10.40.00.2-0.1-0.00.1-0.6-0.50.10.0-0.0-0.00.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.50.40.30.4-0.10.50.70.40.40.40.20.1-0.0
Pavlov. Cond. response bias0.30.52.60.70.20.9-0.10.51.60.10.70.70.6-0.20.3
Time in closed arm before self-admin0.60.71.70.90.41.00.10.31.30.51.21.01.2-0.60.7
Time in closed arm after self-admin0.70.71.80.80.60.7-0.30.30.90.11.21.30.9-1.01.0
Time in open arm before self-admin0.40.41.2-0.3-0.6-0.3-0.7-0.6-0.2-1.10.20.50.5-0.90.9
Time in open arm after self-admin1.11.22.4-1.3-1.2-1.1-0.6-1.2-1.1-0.8-1.5-1.5-0.70.8-0.8
Bone: periosteal estimation1.32.65.0-2.2-2.2-2.1-1.3-2.0-1.7-1.8-1.6-1.2-0.0-0.70.7
Bone: periosteal perimeter1.62.86.3-2.0-2.5-1.7-1.7-2.5-1.3-2.0-1.2-0.70.5-1.31.3
Bone: post-yield work0.30.51.5-0.9-0.9-0.6-0.7-1.20.0-0.8-0.7-0.40.3-0.50.5
Progressive ratio test 1 active lever presses1.01.23.00.91.40.71.71.40.11.50.3-0.4-1.01.2-1.2
Progressive ratio test 1 breakpoint0.91.22.80.91.40.71.71.40.11.40.3-0.3-0.91.1-1.2
Progressive ratio test 1 inactive lever presses0.30.41.10.80.80.91.00.70.80.70.50.10.10.3-0.3
Progressive ratio test 2 active lever presses0.40.41.30.40.90.21.20.7-0.60.70.3-0.1-0.90.6-0.6
Progressive ratio test 2 breakpoint0.40.51.50.50.90.21.20.7-0.60.80.3-0.1-0.90.6-0.6
Progressive ratio test 2 inactive lever presses0.20.30.60.70.70.60.60.60.30.40.80.50.1-0.10.1
Incentive Sensitization - Responses0.10.20.90.10.4-0.20.30.2-1.00.30.20.0-0.70.2-0.2
Incentive Sensitization - Breakpoint0.10.20.60.20.5-0.10.50.3-0.80.30.30.1-0.70.2-0.2
Sum of active levers in priming session hrs 5-60.80.72.61.00.41.0-0.10.61.60.31.11.00.8-0.60.5
Progressive ratio0.00.10.3-0.2-0.5-0.2-0.0-0.10.1-0.5-0.2-0.3-0.0-0.00.1
Food seeking constrained by brief footshock3.34.18.7-2.7-1.9-2.7-0.7-1.7-2.9-1.0-2.6-2.4-1.71.2-0.9
Seeking ratio, punishment vs. effort1.21.75.1-1.4-0.5-1.50.2-0.6-2.30.3-1.7-1.6-1.51.2-1.1
Retroperitoneal fat weight0.52.24.8-1.8-1.0-2.10.4-0.1-1.60.1-2.2-2.1-1.91.0-1.0
Reaction time number correct0.40.71.70.5-0.00.7-0.8-0.40.4-0.61.01.31.3-1.11.1
Reaction time mean minus median1.84.59.9-1.4-2.3-1.1-3.1-2.6-0.6-3.10.01.32.1-2.62.4
Reaction time mean minus median AUC1.84.610.6-1.2-2.3-0.9-3.3-2.6-0.6-3.10.21.42.2-2.72.5
Reaction time num false alarms0.81.12.71.01.01.11.50.91.61.10.1-0.5-0.71.1-1.1
Reaction time num false alarms AUC0.50.82.30.70.80.91.30.51.50.9-0.1-0.6-0.71.1-1.0
Reaction time trials correct on left0.40.71.70.5-0.00.7-0.8-0.40.4-0.61.01.31.3-1.11.1
Reaction time trials on left0.40.71.50.5-0.00.6-0.8-0.40.3-0.61.01.21.2-1.11.0
Reaction time mean1.42.35.20.8-0.30.9-1.3-0.30.5-1.21.92.32.1-2.12.2
Reaction time mean AUC1.11.74.00.3-0.70.3-1.4-0.6-0.0-1.31.31.81.8-1.92.0
Median of all reaction times1.72.46.31.70.71.7-0.30.80.9-0.22.52.41.8-1.61.7
Reaction time omissions0.20.21.0-0.3-0.2-0.4-0.8-0.5-1.0-0.60.10.3-0.1-0.30.2
Reaction time false alarm rate0.71.02.50.50.70.61.60.81.01.1-0.5-1.0-1.21.3-1.3
Reaction time premature initiation rate0.81.12.3-1.4-1.0-1.4-0.1-1.1-1.3-0.3-1.5-1.4-0.90.5-0.4
Reaction time premature initiations0.30.51.2-1.0-0.9-0.9-0.5-1.1-0.8-0.5-0.8-0.6-0.2-0.00.2
Std. dev. reaction times2.24.08.5-0.9-2.0-0.6-2.8-2.2-0.5-2.90.51.62.2-2.72.6
Reaction time trials completed0.40.71.50.5-0.00.6-0.8-0.40.3-0.61.01.21.2-1.11.0
Reaction time trials AUC0.30.51.20.50.10.6-0.7-0.40.3-0.50.91.11.1-0.90.9
Run reversals in cocaine runway, females2.52.55.6-0.11.2-0.52.11.2-1.11.7-0.9-1.3-2.22.3-2.4
Run reversals in cocaine runway, males0.70.71.80.80.40.7-0.40.71.4-0.31.21.21.0-0.50.7
Latency to leave start box in cocaine runway0.10.10.30.10.10.00.50.20.20.3-0.0-0.3-0.20.2-0.3
Latency to leave start box in cocaine runway, F0.00.10.20.10.10.10.20.00.40.3-0.0-0.2-0.30.2-0.3
Latency to leave start box in cocaine runway, M0.10.10.30.30.20.30.50.3-0.1-0.00.40.10.1-0.30.1
Std. dev. time between licks in bursts0.70.92.0-1.4-1.1-1.4-1.2-1.0-1.3-0.6-1.0-0.7-0.2-0.20.1
Total sessions with >9 infusions3.94.810.62.33.11.83.33.10.53.01.30.2-1.51.7-1.7
Short access day 1 total inactive lever presses0.81.02.61.40.51.60.50.11.00.31.41.21.2-0.90.9
Short access day 10 total inactive lever presses0.61.53.6-1.3-1.9-0.9-1.0-1.9-0.4-1.7-0.9-0.50.8-1.01.1
Short access day 1 total infusions4.25.512.62.03.21.43.53.0-0.13.41.0-0.3-2.22.3-2.3
Short access day 10 total infusions1.51.94.31.71.91.52.11.80.51.91.20.6-0.40.6-0.7
Short access total infusions2.43.07.41.52.31.12.72.4-0.22.50.8-0.1-1.51.6-1.6
Short access day 1 locomotion3.64.510.22.33.01.93.22.90.72.81.30.2-1.41.7-1.7
Short access day 10 total locomotion0.81.43.91.11.41.02.01.30.91.50.3-0.6-0.91.2-1.2
Short access total locomotion3.03.69.82.02.41.83.12.51.22.51.0-0.1-1.11.4-1.5
One hour access (0.3 mA shock)0.70.82.60.81.10.71.60.90.31.00.3-0.4-0.71.0-0.9
Compulsive drug intake1.92.24.1-2.0-1.3-2.0-0.6-1.2-1.8-0.9-2.0-1.9-1.20.9-0.8
One hour access (shock baseline)1.21.83.81.91.71.81.51.41.31.11.71.20.2-0.10.1
Social response proportion0.30.40.90.80.90.70.20.5-0.40.90.80.7-0.2-0.10.1
Social responses0.10.20.40.60.60.40.30.5-0.00.60.40.3-0.2-0.00.0
Social time1.62.14.22.11.52.01.01.61.70.61.91.80.8-0.50.6
Soleus weight0.10.40.9-0.1-0.50.0-0.9-0.60.1-0.80.10.50.9-0.80.7
Bone: stiffness0.10.20.8-0.3-0.50.1-0.2-0.90.5-0.4-0.4-0.30.3-0.10.1
Tibialis anterior weight0.00.10.30.2-0.30.30.20.10.4-0.10.30.30.6-0.40.4
Time to tail flick, vehicle, before self-admin0.20.20.60.30.80.10.30.5-0.00.6-0.1-0.0-0.50.6-0.7
Time to tail flick, vehicle, after self-admin0.40.61.4-1.0-1.1-1.0-0.4-0.5-0.9-0.7-1.2-0.5-0.30.0-0.0
Time to tail flick, test, before self-admin1.41.53.3-1.7-1.2-1.7-0.7-1.2-1.0-0.5-1.8-1.5-0.90.6-0.6
Time to tail flick, test, after self-admin0.30.31.4-0.9-0.4-1.2-0.2-0.0-0.8-0.1-0.5-0.5-0.70.3-0.1
Delta time to tail flick, vehicle, before/after SA0.50.51.3-0.6-1.1-0.3-0.6-0.8-0.2-1.0-0.30.00.6-0.70.8
Delta time to tail flick, test, before/after SA0.30.31.00.50.60.20.71.0-0.00.70.60.4-0.20.1-0.0
Tibia length1.13.16.6-2.5-2.2-2.6-0.7-1.6-2.3-1.6-2.2-1.6-0.6-0.10.0
Ambulatory time before self-admin0.50.81.91.11.10.80.71.40.50.61.21.10.3-0.60.6
Ambulatory time after self-admin1.51.74.11.71.91.41.72.00.41.81.10.7-0.40.6-0.5
Bone: tissue strength1.61.63.61.91.61.80.41.31.00.91.91.40.60.0-0.0
Total heroin consumption0.70.81.90.70.20.7-0.80.11.2-0.71.11.41.0-1.01.0
Bone: trabecular number0.10.20.30.50.60.4-0.20.40.20.50.40.3-0.00.4-0.4
Bone: trabecular spacing0.20.20.7-0.2-0.6-0.1-0.4-0.70.2-0.8-0.10.10.3-0.70.7
Bone: trabecular thickness0.40.41.0-0.8-0.4-0.8-0.3-0.4-0.80.2-1.0-0.9-0.40.8-0.8
Bone: trabecular tissue density0.10.10.60.1-0.10.1-0.8-0.3-0.1-0.40.30.30.3-0.20.2
Water consumed over 24 hours1.01.42.9-0.6-1.5-0.3-1.3-1.40.8-1.7-0.10.61.4-1.51.5
Number of responses in last shaping day0.50.61.31.11.11.00.60.80.20.71.00.80.10.0-0.1