Hub : Genes

Acp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Acp7 0.09 0.07 1.0e-04 0.02 0.04 0.03 0.05 3.8e-02 2.5e-03 6.0e-03 8.8e-04
2 PL gene expression Acp7 0.28 0.14 0.0e+00 0.26 0.27 0.26 0.27 7.4e-29 2.5e-29 1.9e-28 1.7e-29
3 IL gene expression Acp7 0.18 0.12 3.8e-04 0.07 0.05 0.02 0.09 1.1e-02 3.0e-02 1.1e-01 4.1e-03
4 LHb gene expression Acp7 0.31 0.16 1.5e-05 0.16 0.17 0.17 0.17 1.0e-04 8.1e-05 9.5e-05 8.8e-05
5 Brain gene expression Acp7 0.19 0.1 5.0e-16 0.15 0.16 0.13 0.15 4.9e-14 3.5e-15 2.7e-12 3.6e-14
6 pVTA gene expression Acp7 0.28 0.15 4.3e-09 0.16 0.18 0.19 0.17 1.4e-07 3.5e-08 8.6e-09 8.9e-08
7 NAcc gene expression Acp7 0.35 0.23 0.0e+00 0.21 0.22 0.21 0.21 5.5e-24 1.5e-25 2.8e-24 3.6e-24
8 OFC gene expression Acp7 0.27 0.16 1.4e-05 0.2 0.24 0.24 0.23 1.4e-05 2.5e-06 2.2e-06 3.0e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.50.91.30.4-0.8-1.0-1.0-1.10.8-1.11.1
Area under the delay curve0.30.40.50.00.60.70.70.7-0.60.6-0.7
BMI with tail0.30.81.30.81.10.90.90.9-1.10.9-0.5
BMI without tail0.20.41.4-0.30.70.50.60.6-1.20.6-0.2
Body weight1.14.811.1-3.3-2.1-2.2-1.9-1.91.0-2.32.1
Weight adjusted by age0.20.20.20.40.50.40.40.4-0.40.5-0.4
Bone surface1.32.33.2-0.5-1.6-1.7-1.6-1.71.3-1.81.7
Bone volume1.22.12.9-0.5-1.4-1.6-1.5-1.61.2-1.71.6
Breakpoint value in progressive ratio session3.94.37.2-1.22.12.02.22.2-2.72.1-1.8
Number of licking bursts1.41.72.31.5-1.4-1.1-1.2-1.31.2-1.11.5
Context. condit. distance diff. score0.10.10.40.30.50.30.30.3-0.60.30.1
Locomotion velocity, session 11.41.62.91.71.41.31.21.1-0.91.2-0.9
Locomotion distance, session 10.20.30.9-1.0-0.4-0.5-0.4-0.4-0.2-0.40.8
Locomotion velocity, session 20.10.20.60.80.50.30.30.3-0.30.3-0.1
Locomotion distance, session 21.41.92.40.81.61.51.51.4-1.51.5-1.2
Locomotion velocity, session 33.84.55.70.3-2.2-2.2-2.3-2.32.2-2.22.4
Locomotion distance, session 32.73.06.8-2.6-1.8-1.7-1.5-1.50.8-1.61.7
Stereotopy head waving bouts, day 30.80.91.50.50.91.11.01.0-0.71.1-1.2
Stereotopy head waving duration, day 31.01.22.91.71.11.10.90.9-0.41.0-1.1
Locomotion velocity, session 71.21.41.90.1-1.1-1.2-1.3-1.31.4-1.41.1
Locomotion distance, session 70.81.01.3-0.3-0.9-1.1-1.1-1.10.8-1.11.1
Stereotopy head waving bouts, day 70.30.30.60.20.60.60.60.6-0.80.6-0.4
Stereotopy head waving duration, day 71.41.72.01.11.41.41.41.3-1.21.4-1.2
Locomotion velocity, session 80.40.53.61.9-0.0-0.0-0.2-0.20.4-0.10.4
Locomotion distance, session 81.52.23.70.81.71.51.51.5-1.91.5-0.9
Degree of sensitization distance0.60.73.81.90.70.50.40.40.10.4-0.5
Degree of sensitization stereotypy0.91.02.00.01.11.01.11.1-1.41.1-0.7
Conditioned locomotion2.22.63.9-0.8-2.0-1.7-1.7-1.71.4-1.71.7
Cocaine response after cond. corrected0.91.01.3-0.7-1.0-1.1-1.1-1.01.1-1.00.7
Cocaine response after cond. not corrected0.91.01.3-1.0-1.0-1.1-1.1-1.10.9-1.10.9
Cocaine response before conditioning0.40.52.4-1.60.20.10.20.2-1.10.20.3
Saline control response2.12.73.9-0.71.71.61.71.7-2.01.7-1.7
Bone: connectivity density0.30.51.11.0-0.6-0.6-0.7-0.70.6-0.70.8
Bone: cortical apparent density2.53.34.31.72.11.91.81.8-1.51.9-1.7
Bone: cortical area0.30.53.5-1.9-0.0-0.10.10.1-0.5-0.1-0.1
Bone: cortical porosity0.20.20.60.80.50.30.30.3-0.30.30.0
Bone: cortical porosity0.20.20.60.80.50.40.40.3-0.40.40.1
Bone: cortical thickness0.20.31.7-1.3-0.10.00.10.2-0.5-0.0-0.1
Bone: cortical thickness0.20.20.30.1-0.5-0.5-0.5-0.50.5-0.50.5
Bone: cortical tissue density2.43.14.11.92.01.91.81.7-1.41.8-1.7
Condit. Reinf. active minus inactive responses0.20.20.40.4-0.6-0.4-0.4-0.40.7-0.40.3
Condit. Reinf. active-inactive response ratio0.00.00.10.3-0.10.10.00.10.30.1-0.3
Condit. Reinf. active responses0.20.31.21.1-0.5-0.3-0.4-0.40.7-0.40.2
Condit. Reinf. inactive responses0.10.11.01.00.00.0-0.1-0.10.1-0.10.1
Incentive salience index mean1.21.42.00.0-1.4-1.2-1.3-1.31.4-1.31.1
Condit. Reinf. lever presses0.81.11.4-0.3-1.2-1.1-1.1-1.11.0-1.11.1
Condit. Reinf. active minus inactive responses0.70.85.6-2.4-0.2-0.20.10.1-1.00.00.3
Condit. Reinf. active-inactive response ratio1.41.43.4-1.90.80.81.01.1-1.81.0-0.6
Condit. Reinf. active responses0.71.07.0-2.7-0.5-0.4-0.2-0.2-0.7-0.20.5
Condit. Reinf. inactive responses0.20.21.7-1.3-0.3-0.2-0.1-0.1-0.0-0.2-0.0
Condit. Reinf. lever presses2.12.99.5-3.1-1.8-1.6-1.3-1.30.4-1.41.5
Condit. Reinf. lever reinforcers received1.21.78.6-2.9-1.0-1.0-0.7-0.7-0.2-0.81.0
Conditioned reinforcement - actives0.90.91.2-0.5-1.1-1.1-1.0-1.00.8-0.90.9
Conditioned reinforcement - inactives2.42.73.2-1.6-1.8-1.7-1.6-1.61.4-1.81.5
Conditioned locomotion0.50.61.31.1-0.6-0.6-0.7-0.70.9-0.60.5
Patch foraging indifference point 0 sec0.10.20.5-0.7-0.3-0.5-0.4-0.4-0.1-0.30.5
Patch foraging indifference point AUC2.02.33.20.61.81.71.71.6-1.41.5-1.4
Delay disc. indifference point, 0s delay2.02.23.3-0.51.51.51.61.6-1.81.6-1.4
Delay disc. indifference point, 16s delay0.40.51.1-1.1-0.7-0.7-0.6-0.60.4-0.60.5
Delay disc. indifference point, 2s delay0.10.10.20.30.40.40.40.4-0.30.4-0.4
Delay disc. indifference point, 24s delay1.21.21.7-1.1-1.2-1.1-1.1-1.01.0-1.30.9
Delay disc. indifference point, 4s delay0.10.10.1-0.10.20.20.30.3-0.30.3-0.3
Delay disc. indifference point, 8s delay1.92.02.41.01.61.51.51.5-1.21.4-1.4
Indifference point function ln k2.33.34.4-0.8-2.1-2.0-2.0-1.91.7-1.91.8
Indifference point function log k2.33.34.4-0.8-2.1-2.0-2.0-1.91.7-1.91.8
Patch foraging total patch changes 0 sec0.20.30.6-0.8-0.5-0.6-0.5-0.50.1-0.50.7
Patch foraging total patch changes 12 sec0.30.40.5-0.60.70.50.60.6-0.70.5-0.6
Patch foraging total patch changes 18 sec3.84.86.00.32.52.42.42.4-2.32.2-2.2
Patch foraging total patch changes 24 sec0.10.10.8-0.90.00.10.20.2-0.30.0-0.1
Patch foraging total patch changes 6 sec0.60.91.9-0.31.11.01.01.0-1.40.9-0.6
Patch foraging time to switch 0 sec0.40.62.11.40.70.70.60.6-0.00.6-0.9
Patch foraging water rate 0 sec1.72.73.80.7-1.6-1.7-1.8-1.81.7-1.72.0
Patch foraging water rate 12 sec2.84.25.1-1.2-2.3-2.2-2.1-2.12.1-2.22.0
Patch foraging water rate 18 sec1.72.22.90.9-1.4-1.5-1.6-1.61.6-1.51.7
Patch foraging water rate 24 sec1.62.23.5-0.8-1.5-1.7-1.6-1.61.0-1.51.9
Patch foraging water rate 6 sec2.63.84.4-0.4-2.1-2.1-2.1-2.12.0-2.12.0
Seeking ratio, delayed vs. immediate footshock0.20.21.3-1.10.00.00.10.1-0.30.0-0.0
Distance traveled before self-admin0.40.42.6-1.6-0.4-0.4-0.3-0.3-0.1-0.40.4
Distance traveled after self-admin1.11.26.3-2.5-0.9-0.9-0.7-0.70.0-0.80.8
Extensor digitorum longus weight0.00.10.80.9-0.10.10.10.0-0.10.10.1
Bone: elastic displacement0.00.00.10.3-0.3-0.2-0.2-0.20.3-0.20.1
Bone: elastic work1.31.63.2-1.8-1.4-1.3-1.2-1.10.7-1.31.2
Bone: endosteal estimation0.20.52.3-1.50.50.40.50.5-0.60.4-0.7
Bone: endosteal perimeter0.10.31.9-1.4-0.1-0.3-0.1-0.1-0.1-0.20.1
Epididymis fat weight0.00.10.20.20.30.30.30.3-0.10.3-0.4
Delta time in closed arm before/after self-admin2.01.92.4-0.6-1.5-1.5-1.5-1.51.4-1.51.3
Delta time in open arm before/after self-admin0.00.00.00.10.10.10.10.1-0.10.1-0.1
Diff in mean of infusions in LGA sessions1.82.02.8-0.31.51.51.61.6-1.71.5-1.3
Delay discount exponential model param0.20.20.20.0-0.4-0.5-0.5-0.50.4-0.40.5
Extinction: sum of active levers before priming2.02.03.6-0.91.41.41.51.5-1.91.4-1.2
Active lever presses in extinction session 60.40.40.7-0.40.60.60.70.6-0.80.5-0.5
Bone: final force0.30.63.1-1.8-0.4-0.6-0.4-0.40.1-0.60.4
Bone: final moment0.61.04.7-2.2-0.7-0.9-0.7-0.70.2-0.90.6
Food consumed during 24 hour testing period1.82.13.0-0.7-1.7-1.6-1.5-1.51.4-1.51.5
Glucose2.33.55.20.8-2.0-1.8-2.0-2.02.3-2.01.7
Heart weight0.30.51.4-1.2-0.7-0.6-0.5-0.50.1-0.50.9
Delay discount hyperbolic model param0.20.20.3-0.1-0.5-0.5-0.5-0.60.5-0.50.5
Intermittent access intake day 1-15 change0.20.21.1-1.10.20.20.30.3-0.50.1-0.2
Intermittent access intake escalation0.10.10.7-0.80.00.00.10.1-0.30.0-0.0
Intermittent access intake escalation 22.32.34.0-1.71.31.31.51.5-2.01.3-1.2
Intermitt. access day 1 inactive lever presses4.14.45.4-0.4-2.3-2.2-2.3-2.32.3-2.32.0
Intermitt. access day 15 inactive lever presses4.55.06.1-0.4-2.4-2.4-2.4-2.42.5-2.52.1
Intermitt. access escalation Index0.60.51.0-0.30.70.60.70.7-1.00.8-0.6
Intermittent access day 1 total infusions2.32.73.5-0.1-1.9-1.8-1.9-1.81.7-1.61.6
Intermittent access day 15 total infusions1.11.21.5-1.0-1.2-1.2-1.1-1.10.8-1.11.1
Intermittent access terminal intake (last 3 days)0.80.81.8-1.4-1.0-0.9-0.8-0.80.5-0.90.8
Intermittent access total infusions1.82.02.6-0.8-1.6-1.6-1.5-1.51.3-1.41.4
Intermittent access day 1 locomotion2.12.22.9-0.1-1.7-1.7-1.7-1.71.5-1.41.5
Intermittent access day 15 total locomotion1.01.11.30.2-1.1-1.1-1.2-1.21.2-1.01.0
Intermittent access total locomotion1.31.52.00.6-1.3-1.2-1.3-1.31.4-1.11.1
Intermittent access standard deviation1.11.24.7-2.20.60.60.80.8-1.40.6-0.5
Left kidney weight1.33.68.9-3.0-1.9-1.9-1.6-1.60.7-1.81.9
Right kidney weight1.13.012.4-3.5-1.6-1.5-1.2-1.20.5-1.41.3
Cocaine induced anxiety0.30.40.5-0.00.70.70.70.7-0.70.7-0.6
Post-drug Anxiety0.60.60.80.70.90.80.80.8-0.60.9-0.7
Baseline Anxiety0.10.10.10.3-0.2-0.2-0.3-0.30.2-0.20.2
Tail length1.44.214.8-3.8-1.8-1.9-1.5-1.50.4-1.91.9
Length with tail3.111.528.8-5.4-3.4-3.3-2.9-2.91.8-3.43.0
Length without tail2.45.29.0-3.0-2.5-2.3-2.1-2.11.8-2.41.8
Times rat made contact with spout1.11.31.80.61.41.21.21.2-1.21.2-0.9
Lifetime Intake1.31.41.9-0.3-1.4-1.3-1.4-1.31.2-1.21.2
Liver weight, left0.10.10.50.20.40.30.30.3-0.70.30.2
Liver weight, right0.20.30.7-0.1-0.4-0.6-0.6-0.60.4-0.70.8
Locomotor activity0.61.01.30.80.91.11.11.0-0.81.0-1.0
Locomotor testing distance0.61.01.41.21.01.11.01.0-0.61.0-1.1
Locomotor testing rearing4.97.69.21.43.03.03.02.9-2.62.9-2.8
Locomotion in novel chamber1.82.22.70.91.71.61.61.6-1.51.6-1.4
Locomotion in novel chamber post-restriction0.00.00.0-0.1-0.1-0.1-0.1-0.10.0-0.10.0
Fecal boli incidents, locomotor time 11.41.64.42.1-0.9-0.9-1.1-1.11.6-0.80.8
Change in fecal boli incidents, locomotor task4.84.66.6-0.52.22.22.32.3-2.62.3-2.0
Time >=10cm from walls, locomotor time 10.00.00.00.1-0.2-0.1-0.1-0.20.2-0.10.1
Bouts of movement, locomotor time 10.60.61.0-0.40.80.80.80.8-1.00.8-0.8
Total resting periods, locomotor time 10.10.20.2-0.30.30.40.40.4-0.50.4-0.4
Rest time, locomotor task time 10.40.40.60.3-0.7-0.7-0.7-0.70.8-0.50.5
Distance moved, locomotor task time 10.20.20.3-0.40.50.40.50.5-0.60.4-0.4
Vertical activity count, locomotor time 10.50.51.2-1.10.50.50.60.6-0.90.5-0.4
Time >=10cm from walls, locomotor time 20.30.30.4-0.20.60.50.60.6-0.60.5-0.5
Bouts of movement, locomotor time 21.01.12.00.4-1.1-1.0-1.1-1.11.4-1.00.8
Total resting periods, locomotor time 20.80.91.60.4-1.0-0.9-1.0-1.01.3-0.90.7
Rest time, locomotor task time 20.30.40.5-0.6-0.7-0.6-0.6-0.60.6-0.70.5
Distance moved, locomotor task time 21.31.52.10.31.41.31.31.3-1.41.3-1.0
Vertical activity count, locomotor time 21.82.03.2-0.11.61.41.51.5-1.81.5-1.2
Light reinforcement 10.00.10.40.60.20.30.20.20.10.1-0.2
Light reinforcement 21.31.710.03.2-0.3-0.4-0.7-0.81.3-0.50.6
Bone: marrow area0.30.62.4-1.60.50.40.50.6-0.70.4-0.7
Bone: maximum diameter0.71.22.6-1.6-1.1-1.2-1.0-1.00.7-1.20.9
Bone: maximum force0.40.75.3-2.3-0.0-0.20.00.1-0.6-0.2-0.1
Bone: maximum moment0.61.07.0-2.6-0.3-0.4-0.2-0.1-0.5-0.40.1
Mean time between licks in bursts0.10.20.3-0.6-0.4-0.5-0.4-0.40.2-0.40.5
Mean num. licks in bursts2.73.24.4-0.92.11.81.91.9-1.81.7-2.0
Cd content in liver3.43.85.60.71.92.12.12.1-2.42.2-1.5
Co content in liver0.20.32.21.50.10.10.0-0.00.20.1-0.1
Cu content in liver2.32.83.5-1.3-1.7-1.9-1.8-1.81.4-1.81.8
Fe content in liver0.50.60.80.7-0.5-0.7-0.8-0.80.9-0.80.8
K content in liver1.21.22.5-0.9-1.1-1.2-1.1-1.10.4-1.11.6
Mg content in liver1.61.72.7-0.4-1.2-1.4-1.4-1.41.1-1.41.6
Mn content in liver0.20.20.8-0.90.20.20.30.3-0.40.3-0.3
Na content in liver1.21.25.8-2.4-0.9-0.9-0.7-0.70.0-0.80.9
Rb content in liver0.10.10.5-0.1-0.1-0.4-0.3-0.40.0-0.40.7
Se content in liver1.01.33.82.01.31.00.90.9-0.41.0-0.9
Sr content in liver0.20.20.80.8-0.9-0.1-0.1-0.1-0.2-0.00.6
Zn content in liver0.70.71.30.6-0.7-0.9-0.9-0.90.8-0.91.1
Bone: minimum diameter1.93.510.8-3.31.21.31.61.7-2.21.4-1.6
Time in familiar zone, hab. session 10.30.20.4-0.40.40.50.50.5-0.60.4-0.5
Time in novel zone, hab. session 10.00.00.10.2-0.0-0.1-0.1-0.20.1-0.10.3
Total zone transitions, hab. session 12.23.06.7-0.71.81.71.91.8-2.61.8-1.0
Total locomotion distance, hab. session 12.94.18.8-1.91.91.82.12.0-3.01.9-1.3
Locomotion velocity, hab. session 12.23.06.6-1.21.81.61.81.8-2.61.7-1.0
Time in familiar zone, hab. session 20.10.10.3-0.6-0.0-0.3-0.2-0.2-0.0-0.30.4
Time in novel zone, hab. session 20.10.10.60.70.20.30.30.3-0.10.3-0.3
Total zone transitions, hab. session 20.10.10.60.10.40.30.30.3-0.80.30.2
Total locomotion distance, hab. session 20.50.61.6-0.80.70.70.80.8-1.30.8-0.4
Locomotion velocity, hab. session 20.40.61.5-0.70.60.70.80.8-1.20.7-0.4
Novel to familiar place preference ratio1.92.03.9-1.01.31.31.51.5-2.01.4-1.1
Novelty place preference1.21.22.6-0.91.01.01.11.1-1.61.0-0.8
Time in novel zone, NPP test1.31.32.8-0.71.11.11.21.2-1.71.1-0.9
Total zone transitions, NPP test0.10.10.40.60.20.10.20.1-0.40.10.3
Total locomotion distance, NPP test1.11.53.8-1.41.11.01.21.2-1.91.1-0.5
Locomotion velocity, NPP test1.11.53.8-1.61.00.91.11.1-1.91.0-0.5
Intraocular pressure0.40.61.10.5-0.6-0.7-0.8-0.81.1-0.90.6
Delta distance traveled before/after self-admin0.00.00.3-0.6-0.1-0.1-0.0-0.1-0.1-0.10.1
Delta ambulatory time before/after self-admin0.10.21.0-1.00.00.00.10.1-0.50.1-0.1
Parametrial fat weight0.30.50.80.9-0.7-0.6-0.7-0.70.9-0.60.7
Pavlov. Cond. lever latency0.10.10.20.40.50.40.30.3-0.40.4-0.3
Pavlov. Cond. magazine entry latency0.20.20.50.4-0.3-0.5-0.5-0.50.4-0.40.7
Pavlov. Cond. change in total contacts0.10.10.3-0.0-0.5-0.4-0.4-0.40.5-0.40.2
Pavlov. Cond. index score0.10.20.3-0.1-0.4-0.4-0.4-0.40.3-0.40.5
Pavlov. Cond. latency score0.10.20.2-0.2-0.4-0.4-0.4-0.40.4-0.40.4
Pavlov. Cond. lever contacts0.60.70.9-0.9-0.9-0.9-0.8-0.80.6-0.80.8
Pavlov. Cond. magazine entry number0.00.00.1-0.20.00.10.10.1-0.00.1-0.3
Pavlov. Cond. intertrial magazine entries0.50.61.00.30.70.90.80.8-0.70.8-1.0
Pavlov. Cond. lever-magazine prob. diff.0.20.30.5-0.3-0.5-0.6-0.6-0.60.4-0.60.7
Pavlov. Cond. response bias0.20.20.5-0.3-0.5-0.6-0.5-0.50.3-0.50.7
Pavlov. Cond. lever latency0.91.24.32.11.21.00.80.8-0.20.9-1.0
Pavlov. Cond. magazine entry latency3.74.35.6-1.4-2.4-2.2-2.2-2.11.6-2.22.2
Pavlov. Cond. change in total contacts1.01.48.7-2.9-0.9-0.7-0.5-0.5-0.3-0.60.6
Pavlov. Cond. index score1.82.33.5-1.9-1.7-1.6-1.4-1.40.8-1.51.6
Pavlov. Cond. latency score2.12.73.6-1.8-1.9-1.7-1.6-1.60.9-1.71.7
Pavlov. Cond. lever contacts0.81.04.1-2.0-1.0-0.9-0.7-0.70.1-0.80.9
Pavlov. Cond. magazine entry number2.02.43.31.01.81.71.61.6-1.11.7-1.8
Pavlov. Cond. intertrial magazine entries0.50.61.40.9-0.5-0.6-0.8-0.81.2-0.70.5
Pavlov. Cond. lever-magazine prob. diff.1.92.53.9-2.0-1.8-1.6-1.5-1.50.7-1.61.7
Pavlov. Cond. response bias1.21.64.6-2.2-1.3-1.2-1.0-1.00.3-1.11.3
Time in closed arm before self-admin0.10.10.10.10.30.30.30.4-0.30.4-0.3
Time in closed arm after self-admin1.61.62.0-0.4-1.4-1.4-1.4-1.41.3-1.31.2
Time in open arm before self-admin0.50.51.3-1.1-0.7-0.7-0.6-0.60.4-0.80.6
Time in open arm after self-admin0.40.51.2-1.10.50.50.60.6-0.90.4-0.5
Bone: periosteal estimation0.40.74.3-2.10.30.30.50.5-0.80.3-0.6
Bone: periosteal perimeter0.30.53.0-1.70.30.10.30.3-0.70.2-0.2
Bone: post-yield work0.30.40.8-0.90.50.50.50.6-0.70.6-0.7
Progressive ratio test 1 active lever presses3.03.14.1-1.4-2.0-2.0-1.9-1.91.4-1.71.7
Progressive ratio test 1 breakpoint3.03.14.0-1.7-2.0-1.9-1.9-1.81.3-1.71.7
Progressive ratio test 1 inactive lever presses2.52.73.5-0.5-1.9-1.8-1.8-1.81.6-1.71.6
Progressive ratio test 2 active lever presses2.83.03.9-0.8-2.0-1.9-1.9-1.91.6-1.81.7
Progressive ratio test 2 breakpoint3.43.84.9-0.9-2.2-2.2-2.1-2.11.9-2.01.9
Progressive ratio test 2 inactive lever presses3.33.84.7-1.7-2.2-2.1-2.0-2.01.6-2.11.8
Incentive Sensitization - Responses1.11.11.50.0-1.1-1.1-1.2-1.21.2-1.11.0
Incentive Sensitization - Breakpoint0.80.81.20.2-0.9-0.9-1.0-1.01.1-1.00.8
Sum of active levers in priming session hrs 5-68.88.511.5-0.23.23.13.23.2-3.43.1-2.7
Progressive ratio1.31.51.91.01.41.31.31.2-1.21.2-1.1
Food seeking constrained by brief footshock0.70.93.4-1.80.50.50.70.7-1.10.7-0.6
Seeking ratio, punishment vs. effort1.51.83.2-1.8-1.5-1.4-1.3-1.31.1-1.31.1
Retroperitoneal fat weight0.10.52.91.7-0.1-0.0-0.2-0.30.9-0.3-0.0
Reaction time number correct0.00.10.2-0.3-0.1-0.2-0.1-0.2-0.2-0.10.5
Reaction time mean minus median0.60.70.9-0.5-0.9-0.9-0.9-0.90.9-0.90.8
Reaction time mean minus median AUC1.51.92.3-0.7-1.5-1.5-1.5-1.51.4-1.51.4
Reaction time num false alarms0.40.51.31.20.50.70.60.5-1.00.7-0.2
Reaction time num false alarms AUC0.50.61.81.30.60.70.70.6-1.00.8-0.3
Reaction time trials correct on left0.00.10.2-0.3-0.1-0.2-0.1-0.2-0.2-0.10.5
Reaction time trials on left0.00.10.3-0.3-0.1-0.2-0.2-0.2-0.2-0.10.5
Reaction time mean0.71.01.40.3-1.1-1.0-1.1-1.11.2-1.01.0
Reaction time mean AUC1.52.02.60.4-1.5-1.5-1.5-1.51.6-1.41.4
Median of all reaction times0.50.71.00.6-0.9-0.8-0.9-0.91.0-0.70.7
Reaction time omissions0.00.00.20.5-0.0-0.1-0.2-0.20.0-0.00.3
Reaction time false alarm rate0.30.41.91.40.30.50.40.3-0.40.5-0.2
Reaction time premature initiation rate0.10.10.20.00.40.40.30.4-0.20.3-0.5
Reaction time premature initiations0.10.10.1-0.10.30.30.30.3-0.30.3-0.2
Std. dev. reaction times1.01.41.7-0.4-1.2-1.3-1.3-1.31.3-1.21.2
Reaction time trials completed0.00.10.3-0.3-0.1-0.2-0.2-0.2-0.2-0.10.5
Reaction time trials AUC0.00.10.2-0.2-0.1-0.2-0.1-0.2-0.2-0.10.5
Run reversals in cocaine runway, females3.53.44.90.5-1.9-1.9-2.0-2.02.2-1.91.7
Run reversals in cocaine runway, males0.20.20.60.80.40.40.30.3-0.00.3-0.3
Latency to leave start box in cocaine runway0.00.00.10.20.00.00.0-0.00.1-0.20.1
Latency to leave start box in cocaine runway, F0.40.50.70.60.80.80.70.7-0.60.6-0.6
Latency to leave start box in cocaine runway, M0.60.60.8-0.1-0.8-0.8-0.8-0.80.9-0.90.7
Std. dev. time between licks in bursts0.30.40.8-0.80.50.50.60.6-0.90.5-0.5
Total sessions with >9 infusions0.00.00.00.1-0.1-0.1-0.1-0.1-0.10.10.1
Short access day 1 total inactive lever presses1.31.51.8-0.7-1.4-1.3-1.3-1.31.2-1.31.2
Short access day 10 total inactive lever presses1.31.51.8-0.3-1.3-1.3-1.3-1.31.3-1.31.2
Short access day 1 total infusions0.70.70.9-0.7-1.0-0.9-0.9-0.90.7-0.90.8
Short access day 10 total infusions0.40.40.50.2-0.7-0.7-0.7-0.70.7-0.50.6
Short access total infusions0.60.70.90.2-0.9-0.9-0.9-0.90.8-0.70.8
Short access day 1 locomotion0.30.41.21.10.60.60.50.4-0.30.6-0.5
Short access day 10 total locomotion0.30.40.6-0.5-0.7-0.7-0.7-0.70.3-0.50.6
Short access total locomotion0.10.10.20.3-0.4-0.3-0.4-0.40.2-0.10.3
One hour access (0.3 mA shock)0.40.51.3-1.2-0.8-0.8-0.7-0.60.3-0.50.7
Compulsive drug intake1.31.32.1-0.51.21.21.21.2-1.51.2-1.0
One hour access (shock baseline)1.31.51.9-0.4-1.4-1.3-1.3-1.31.2-1.21.2
Social response proportion1.01.15.5-2.3-0.9-0.8-0.6-0.6-0.1-0.60.8
Social responses0.81.01.3-0.2-1.1-1.1-1.1-1.11.0-1.01.1
Social time0.30.40.8-0.50.60.60.70.6-0.90.7-0.3
Soleus weight1.54.35.71.72.42.22.22.1-2.22.2-1.5
Bone: stiffness0.40.72.2-1.50.60.50.60.7-1.10.5-0.5
Tibialis anterior weight0.72.23.30.01.41.61.61.6-1.81.7-1.4
Time to tail flick, vehicle, before self-admin1.11.11.5-0.4-1.2-1.1-1.1-1.11.1-1.21.0
Time to tail flick, vehicle, after self-admin1.41.51.8-0.3-1.3-1.3-1.3-1.31.2-1.31.2
Time to tail flick, test, before self-admin0.00.00.1-0.20.10.10.10.2-0.20.1-0.1
Time to tail flick, test, after self-admin0.20.20.2-0.1-0.5-0.5-0.5-0.50.4-0.30.4
Delta time to tail flick, vehicle, before/after SA0.10.10.1-0.2-0.3-0.3-0.3-0.30.2-0.20.2
Delta time to tail flick, test, before/after SA0.30.20.30.0-0.5-0.5-0.5-0.50.5-0.40.5
Tibia length1.13.16.3-2.5-1.9-1.8-1.7-1.61.1-1.81.5
Ambulatory time before self-admin0.20.21.4-1.2-0.2-0.1-0.0-0.0-0.2-0.10.1
Ambulatory time after self-admin1.11.26.7-2.6-0.8-0.8-0.6-0.6-0.0-0.80.7
Bone: tissue strength0.70.74.4-2.1-0.7-0.5-0.4-0.30.0-0.40.2
Total heroin consumption6.77.812.4-1.32.92.83.03.0-3.52.8-2.5
Bone: trabecular number0.20.40.6-0.2-0.5-0.7-0.7-0.70.3-0.70.8
Bone: trabecular spacing0.60.72.4-1.60.50.60.70.7-0.90.6-0.7
Bone: trabecular thickness1.62.02.40.4-1.3-1.5-1.5-1.51.5-1.51.5
Bone: trabecular tissue density0.81.13.81.91.11.00.80.8-0.30.9-0.9
Water consumed over 24 hours0.91.11.6-1.1-1.2-1.1-1.0-1.00.6-1.01.3
Number of responses in last shaping day0.70.72.7-1.7-0.8-0.8-0.6-0.60.3-0.80.7