Hub : Genes

Acp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Acp7 0.11 0.09 1.8e-05 0.08 0.08 0.06 0.09 5.8e-05 4.4e-05 2.6e-04 2.3e-05
2 RMTg gene expression Acp7 0.11 0.09 6.6e-03 0.07 0.11 0.05 0.06 6.5e-03 9.3e-04 2.3e-02 1.1e-02
3 LHb gene expression Acp7 0.31 0.17 6.6e-05 0.09 0.15 0.16 0.13 3.3e-03 2.4e-04 1.5e-04 5.1e-04
4 IC gene expression Acp7 0.21 0.11 8.6e-09 0.21 0.22 0.21 0.21 2.2e-09 1.7e-09 3.0e-09 3.0e-09
5 OFC gene expression Acp7 0.27 0.14 2.6e-06 0.24 0.26 0.25 0.25 1.9e-06 5.3e-07 1.3e-06 9.5e-07
6 pVTA gene expression Acp7 0.28 0.14 0.0e+00 0.29 0.28 0.28 0.29 9.9e-24 7.5e-23 7.4e-23 1.3e-23
7 Brain gene expression Acp7 0.19 0.1 0.0e+00 0.19 0.18 0.17 0.18 4.0e-17 1.6e-16 6.7e-16 1.9e-16
8 IL gene expression Acp7 0.18 0.12 3.3e-04 0.1 0.07 0.06 0.07 2.0e-03 8.3e-03 1.7e-02 7.5e-03
9 PL gene expression Acp7 0.29 0.14 0.0e+00 0.26 0.28 0.27 0.27 1.1e-27 2.0e-30 5.6e-29 5.6e-30
10 NAcc gene expression Acp7 0.24 0.12 0.0e+00 0.24 0.23 0.23 0.23 9.4e-36 1.0e-34 2.5e-34 1.5e-34

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density0.40.61.10.2-0.8-0.8-0.8-0.8-1.1-0.8-0.8-0.9-0.8
Area under the delay curve0.30.30.4-0.10.60.60.60.60.60.60.60.60.6
BMI with tail0.41.51.80.61.31.31.31.31.21.21.21.31.3
BMI without tail0.10.41.5-1.2-0.6-0.3-0.5-0.5-0.6-0.6-0.6-0.4-0.4
Body weight1.04.510.4-3.2-2.2-1.8-2.1-2.1-2.1-1.9-1.9-1.6-1.8
Weight adjusted by age0.20.40.40.00.60.70.60.60.60.70.70.70.7
Bone surface1.22.13.0-0.7-1.5-1.5-1.5-1.5-1.7-1.4-1.4-1.5-1.5
Bone volume1.11.92.8-0.8-1.4-1.4-1.5-1.5-1.7-1.3-1.3-1.4-1.4
Breakpoint value in progressive ratio session2.83.44.4-1.31.62.01.81.81.91.91.92.11.9
Number of licking bursts0.81.32.61.5-0.8-1.6-0.9-1.0-0.9-1.1-1.0-1.2-1.1
Context. condit. distance diff. score0.10.10.10.40.30.30.30.30.20.30.20.30.3
Locomotion velocity, session 11.71.82.41.61.41.31.41.41.21.31.31.21.3
Locomotion distance, session 10.20.30.9-1.0-0.5-0.4-0.5-0.5-0.4-0.5-0.6-0.3-0.5
Locomotion velocity, session 20.10.20.50.70.40.50.40.40.10.40.40.30.3
Locomotion distance, session 21.52.02.40.81.61.51.51.51.41.41.41.51.5
Locomotion velocity, session 33.74.25.00.3-2.0-2.2-2.1-2.1-2.0-2.2-2.2-2.2-2.2
Locomotion distance, session 33.33.66.8-2.6-2.1-1.8-1.9-1.9-1.7-1.7-1.7-1.5-1.8
Stereotopy head waving bouts, day 30.70.81.10.51.00.91.01.00.90.90.91.01.0
Stereotopy head waving duration, day 31.21.42.61.61.31.11.21.21.01.11.21.01.1
Locomotion velocity, session 71.01.11.50.0-1.1-1.0-1.2-1.2-1.1-0.9-0.9-1.2-1.2
Locomotion distance, session 70.81.01.4-0.3-1.1-0.8-1.1-1.1-1.2-0.8-0.9-1.1-1.1
Stereotopy head waving bouts, day 71.31.52.10.51.31.21.31.31.41.11.11.31.3
Stereotopy head waving duration, day 71.51.82.11.01.51.31.41.41.51.31.31.41.4
Locomotion velocity, session 80.30.43.82.00.3-0.10.20.1-0.0-0.1-0.2-0.1-0.0
Locomotion distance, session 81.52.12.70.81.51.61.61.61.41.51.41.51.5
Degree of sensitization distance0.70.83.82.00.80.70.70.70.40.70.70.40.6
Degree of sensitization stereotypy0.80.91.2-0.01.01.01.01.01.10.90.91.11.0
Conditioned locomotion2.63.04.6-0.9-1.8-2.1-1.7-1.7-1.7-1.8-1.8-1.7-1.7
Cocaine response after cond. corrected0.91.01.3-0.7-1.1-0.8-1.1-1.1-1.1-1.0-1.0-1.0-1.1
Cocaine response after cond. not corrected1.01.11.5-0.9-1.2-0.8-1.2-1.2-1.2-0.9-0.9-1.1-1.1
Cocaine response before conditioning0.20.32.3-1.5-0.20.2-0.1-0.0-0.00.30.30.20.0
Saline control response1.62.12.7-0.31.41.71.51.51.31.51.61.61.6
Bone: connectivity density0.20.20.60.8-0.3-0.5-0.4-0.4-0.6-0.4-0.4-0.5-0.5
Bone: cortical apparent density2.73.74.21.82.02.02.01.91.72.02.01.81.8
Bone: cortical area0.30.54.4-2.1-0.3-0.3-0.2-0.2-0.1-0.2-0.20.10.0
Bone: cortical porosity0.30.30.40.50.60.40.60.60.60.40.40.60.6
Bone: cortical porosity0.10.10.40.60.50.20.40.40.40.10.10.40.4
Bone: cortical thickness0.20.32.7-1.7-0.2-0.4-0.1-0.1-0.1-0.3-0.20.20.1
Bone: cortical thickness0.20.20.4-0.0-0.5-0.6-0.4-0.4-0.4-0.6-0.6-0.5-0.4
Bone: cortical tissue density2.63.64.01.92.02.01.91.91.72.02.01.71.8
Condit. Reinf. active minus inactive responses0.20.20.60.4-0.4-0.7-0.4-0.4-0.3-0.7-0.6-0.5-0.4
Condit. Reinf. active-inactive response ratio0.00.00.10.30.1-0.20.10.10.3-0.1-0.00.00.1
Condit. Reinf. active responses0.20.31.11.1-0.1-0.6-0.2-0.2-0.2-0.6-0.5-0.4-0.3
Condit. Reinf. inactive responses0.10.11.01.00.2-0.10.10.1-0.1-0.1-0.1-0.00.0
Incentive salience index mean1.31.62.40.1-1.2-1.6-1.2-1.2-1.1-1.5-1.4-1.3-1.2
Condit. Reinf. lever presses1.21.72.2-0.4-1.3-1.5-1.3-1.3-1.3-1.5-1.4-1.3-1.3
Condit. Reinf. active minus inactive responses0.50.65.3-2.3-0.5-0.1-0.3-0.3-0.3-0.2-0.20.0-0.1
Condit. Reinf. active-inactive response ratio0.70.83.3-1.80.50.90.60.70.50.80.81.00.8
Condit. Reinf. active responses0.60.96.8-2.6-0.8-0.3-0.6-0.6-0.4-0.4-0.5-0.2-0.4
Condit. Reinf. inactive responses0.20.21.7-1.3-0.4-0.2-0.3-0.30.1-0.3-0.3-0.1-0.2
Condit. Reinf. lever presses2.43.39.1-3.0-1.9-1.7-1.7-1.7-1.5-1.6-1.6-1.3-1.5
Condit. Reinf. lever reinforcers received1.31.88.3-2.9-1.4-0.9-1.2-1.1-0.9-1.0-1.1-0.7-1.0
Conditioned reinforcement - actives0.81.41.70.4-1.2-1.3-1.2-1.2-1.3-1.3-1.3-1.3-1.3
Conditioned reinforcement - inactives3.45.05.6-0.9-2.4-2.4-2.4-2.4-2.3-2.3-2.3-2.3-2.3
Conditioned locomotion0.20.32.31.50.0-0.2-0.1-0.1-0.2-0.2-0.2-0.3-0.2
Patch foraging indifference point 0 sec0.20.30.4-0.6-0.6-0.4-0.6-0.6-0.7-0.5-0.5-0.5-0.6
Patch foraging indifference point AUC2.73.95.00.82.12.12.12.12.22.12.12.01.9
Delay disc. indifference point, 0s delay2.02.22.7-0.41.51.61.51.51.61.61.61.61.6
Delay disc. indifference point, 16s delay0.60.71.2-1.1-0.9-0.8-0.8-0.8-0.8-0.8-0.8-0.7-0.8
Delay disc. indifference point, 2s delay0.20.20.20.30.40.50.50.50.40.40.40.40.4
Delay disc. indifference point, 24s delay1.41.61.8-1.1-1.3-1.3-1.3-1.3-1.2-1.3-1.2-1.2-1.2
Delay disc. indifference point, 4s delay0.10.10.1-0.10.30.30.30.30.30.30.30.30.3
Delay disc. indifference point, 8s delay1.82.12.41.01.61.51.51.51.51.41.51.41.5
Indifference point function ln k2.34.04.9-0.7-2.1-2.1-2.1-2.1-2.2-2.0-2.0-2.0-2.0
Indifference point function log k2.34.04.9-0.7-2.1-2.1-2.1-2.1-2.2-2.0-2.0-2.0-2.0
Patch foraging total patch changes 0 sec0.30.50.7-0.7-0.8-0.6-0.7-0.7-0.8-0.6-0.6-0.7-0.7
Patch foraging total patch changes 12 sec0.20.20.4-0.50.40.60.40.40.50.50.50.50.4
Patch foraging total patch changes 18 sec3.55.46.50.52.52.52.42.42.62.42.42.42.3
Patch foraging total patch changes 24 sec0.00.10.6-0.8-0.1-0.1-0.1-0.10.00.00.00.0-0.1
Patch foraging total patch changes 6 sec0.40.70.9-0.20.80.90.80.80.80.90.90.90.8
Patch foraging time to switch 0 sec0.30.61.81.40.90.60.80.80.50.60.60.60.7
Patch foraging water rate 0 sec1.12.43.10.7-1.5-1.6-1.6-1.6-1.6-1.6-1.6-1.8-1.7
Patch foraging water rate 12 sec2.34.85.7-1.2-2.3-2.3-2.3-2.3-2.4-2.2-2.2-2.2-2.2
Patch foraging water rate 18 sec1.32.02.50.8-1.3-1.4-1.4-1.4-1.6-1.5-1.5-1.6-1.5
Patch foraging water rate 24 sec1.72.43.1-0.7-1.7-1.6-1.6-1.6-1.8-1.5-1.5-1.6-1.5
Patch foraging water rate 6 sec2.63.84.4-0.3-2.0-2.1-2.0-2.0-2.0-2.1-2.1-2.1-2.1
Seeking ratio, delayed vs. immediate footshock0.20.21.7-1.3-0.00.10.00.10.10.2-0.40.20.2
Distance traveled before self-admin0.60.72.8-1.7-0.9-0.7-0.8-0.8-0.7-0.7-0.7-0.5-0.6
Distance traveled after self-admin0.50.62.9-1.7-0.8-0.6-0.7-0.7-0.6-0.6-0.6-0.4-0.5
Extensor digitorum longus weight0.00.11.01.00.2-0.20.20.20.2-0.1-0.10.10.1
Bone: elastic displacement0.10.10.20.1-0.2-0.4-0.2-0.2-0.5-0.4-0.5-0.2-0.2
Bone: elastic work1.72.23.7-1.9-1.5-1.4-1.5-1.4-1.4-1.5-1.5-1.2-1.3
Bone: endosteal estimation0.20.42.0-1.40.20.60.30.30.50.60.60.50.4
Bone: endosteal perimeter0.10.21.7-1.3-0.4-0.1-0.3-0.30.0-0.2-0.2-0.1-0.2
Epididymis fat weight0.10.30.40.0-0.5-0.6-0.5-0.5-0.5-0.6-0.6-0.6-0.5
Delta time in closed arm before/after self-admin1.81.72.10.2-1.3-1.4-1.4-1.4-1.4-1.4-1.4-1.4-1.3
Delta time in open arm before/after self-admin0.00.00.1-0.30.10.20.10.10.20.20.20.20.3
Diff in mean of infusions in LGA sessions1.31.61.9-0.21.31.41.31.31.31.31.31.41.3
Delay discount exponential model param0.20.20.30.2-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Extinction: sum of active levers before priming0.40.52.9-1.70.20.50.30.40.50.50.50.60.5
Active lever presses in extinction session 61.01.01.3-0.41.01.11.01.01.01.11.11.11.0
Bone: final force0.40.72.9-1.7-0.8-0.6-0.7-0.7-0.6-0.7-0.7-0.4-0.5
Bone: final moment0.81.24.6-2.2-1.1-0.9-1.0-1.0-0.9-1.0-1.0-0.7-0.8
Food consumed during 24 hour testing period1.72.33.0-0.6-1.5-1.7-1.5-1.5-1.3-1.7-1.7-1.5-1.5
Glucose2.64.05.60.7-1.8-2.3-1.9-2.0-1.9-2.4-2.4-2.2-2.0
Heart weight0.60.92.2-1.5-0.9-1.0-0.9-0.9-0.7-1.0-1.0-0.7-0.8
Delay discount hyperbolic model param0.20.20.2-0.0-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5
Intermittent access intake day 1-15 change0.00.10.3-0.5-0.3-0.2-0.3-0.3-0.2-0.2-0.2-0.2-0.2
Intermittent access intake escalation0.00.00.2-0.4-0.1-0.0-0.1-0.1-0.0-0.0-0.00.0-0.0
Intermittent access intake escalation 21.11.32.1-1.40.91.21.01.01.11.11.11.31.1
Intermitt. access day 1 inactive lever presses1.03.94.6-2.0-2.2-2.0-2.1-2.1-1.9-1.9-1.9-1.8-1.9
Intermitt. access day 15 inactive lever presses1.73.64.0-0.9-2.0-2.0-2.0-2.0-1.9-1.9-1.9-1.9-1.9
Intermitt. access escalation Index1.01.41.9-0.71.11.31.21.21.31.31.31.41.3
Intermittent access day 1 total infusions1.62.73.10.3-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.8-1.7
Intermittent access day 15 total infusions1.01.51.8-0.4-1.4-1.3-1.3-1.3-1.3-1.3-1.3-1.3-1.3
Intermittent access terminal intake (last 3 days)0.91.21.5-1.0-1.2-1.1-1.2-1.2-1.1-1.1-1.1-1.0-1.1
Intermittent access total infusions2.22.73.0-0.2-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.7
Intermittent access day 1 locomotion1.31.61.9-0.2-1.4-1.4-1.3-1.3-1.3-1.3-1.3-1.3-1.3
Intermittent access day 15 total locomotion0.71.31.60.2-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.3-1.2
Intermittent access total locomotion1.41.72.00.5-1.3-1.4-1.3-1.3-1.4-1.4-1.4-1.4-1.4
Intermittent access standard deviation0.51.13.4-1.80.61.00.80.81.01.01.01.11.0
Left kidney weight0.62.915.8-4.0-1.6-1.1-1.4-1.3-1.2-1.1-1.1-0.7-1.0
Right kidney weight0.83.715.4-3.9-1.9-1.5-1.7-1.7-1.5-1.5-1.5-1.1-1.4
Cocaine induced anxiety1.11.61.80.61.31.31.31.31.31.31.31.31.3
Post-drug Anxiety1.01.01.20.01.01.11.11.11.11.11.11.11.1
Baseline Anxiety1.51.82.1-1.3-1.4-1.3-1.4-1.4-1.3-1.3-1.3-1.2-1.3
Tail length2.18.420.8-4.6-3.1-2.5-2.9-2.8-2.7-2.5-2.4-2.3-2.6
Length with tail3.816.431.1-5.6-4.4-3.7-4.1-4.1-3.9-3.6-3.6-3.4-3.7
Length without tail0.82.75.7-2.4-1.8-1.6-1.7-1.6-1.5-1.5-1.5-1.3-1.4
Times rat made contact with spout1.31.41.80.61.31.31.31.31.31.21.21.21.2
Lifetime Intake1.72.12.40.1-1.5-1.5-1.5-1.5-1.5-1.5-1.5-1.6-1.5
Liver weight, left0.10.10.3-0.5-0.3-0.4-0.3-0.3-0.3-0.4-0.5-0.3-0.3
Liver weight, right0.30.50.9-0.2-0.7-0.5-0.7-0.7-0.9-0.6-0.6-0.7-0.7
Locomotor activity0.81.31.60.81.21.11.11.11.11.31.31.01.1
Locomotor testing distance1.11.92.31.31.51.41.41.41.31.51.51.21.3
Locomotor testing rearing4.48.810.21.43.23.13.13.13.03.23.23.03.1
Locomotion in novel chamber1.41.82.11.01.41.41.41.41.41.41.21.31.4
Locomotion in novel chamber post-restriction0.10.10.10.0-0.3-0.3-0.3-0.3-0.3-0.40.1-0.4-0.4
Fecal boli incidents, locomotor time 10.81.25.32.3-0.6-0.9-0.7-0.8-0.9-0.9-0.9-1.1-0.9
Change in fecal boli incidents, locomotor task4.64.65.4-0.22.22.32.22.22.32.32.32.32.3
Time >=10cm from walls, locomotor time 10.00.00.00.1-0.1-0.2-0.1-0.1-0.1-0.2-0.1-0.1-0.2
Bouts of movement, locomotor time 10.40.50.6-0.50.70.70.70.70.70.70.70.80.7
Total resting periods, locomotor time 10.10.10.2-0.30.30.30.30.30.30.30.30.40.3
Rest time, locomotor task time 10.40.50.60.3-0.6-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7
Distance moved, locomotor task time 10.20.30.3-0.40.50.50.50.50.50.50.50.60.5
Vertical activity count, locomotor time 10.20.41.5-1.20.40.60.50.50.60.60.60.70.6
Time >=10cm from walls, locomotor time 20.10.10.1-0.30.30.30.30.30.30.30.30.40.3
Bouts of movement, locomotor time 20.61.01.30.6-0.9-1.1-1.0-1.0-1.0-1.1-1.0-1.1-1.0
Total resting periods, locomotor time 20.40.71.00.6-0.7-1.0-0.8-0.8-0.9-0.9-0.9-1.0-0.9
Rest time, locomotor task time 20.40.50.6-0.7-0.8-0.8-0.8-0.7-0.7-0.7-0.7-0.7-0.7
Distance moved, locomotor task time 21.31.61.90.21.31.41.31.31.31.31.31.31.3
Vertical activity count, locomotor time 21.52.12.5-0.21.41.61.51.51.51.51.51.61.5
Light reinforcement 10.00.10.30.60.40.20.40.30.30.20.30.20.2
Light reinforcement 20.71.110.13.20.1-0.2-0.1-0.2-0.5-0.3-0.3-0.7-0.5
Bone: marrow area0.20.52.2-1.50.30.70.30.40.60.60.60.60.5
Bone: maximum diameter0.81.43.1-1.8-1.3-1.1-1.2-1.2-1.2-1.0-1.0-1.0-1.1
Bone: maximum force0.40.65.9-2.4-0.5-0.2-0.3-0.3-0.1-0.2-0.20.1-0.0
Bone: maximum moment0.50.97.8-2.8-0.7-0.4-0.5-0.5-0.3-0.4-0.4-0.1-0.3
Mean time between licks in bursts0.10.30.4-0.6-0.6-0.5-0.6-0.6-0.3-0.4-0.4-0.5-0.6
Mean num. licks in bursts1.92.95.4-1.01.62.31.61.71.61.71.71.91.7
Cd content in liver3.33.75.40.82.11.42.12.12.31.71.82.12.2
Co content in liver0.20.21.11.1-0.1-0.5-0.2-0.2-0.1-0.3-0.3-0.3-0.2
Cu content in liver4.24.96.0-1.3-2.4-2.1-2.4-2.4-2.2-2.2-2.2-2.3-2.4
Fe content in liver0.40.51.31.2-0.5-0.6-0.6-0.6-0.3-0.6-0.6-0.8-0.8
K content in liver2.01.92.3-0.9-1.4-1.3-1.4-1.4-1.4-1.5-1.5-1.3-1.5
Mg content in liver2.62.73.5-0.5-1.8-1.4-1.8-1.8-1.7-1.6-1.6-1.8-1.9
Mn content in liver0.20.21.1-1.0-0.5-0.4-0.5-0.4-0.4-0.3-0.3-0.3-0.4
Na content in liver2.02.23.4-1.8-1.6-1.3-1.5-1.5-1.3-1.4-1.4-1.3-1.4
Rb content in liver0.20.30.5-0.2-0.5-0.4-0.6-0.6-0.7-0.5-0.5-0.6-0.6
Se content in liver0.80.93.31.80.80.90.70.71.00.91.00.50.5
Sr content in liver0.70.63.00.6-0.3-1.7-0.4-0.40.3-1.0-1.1-0.5-0.4
Zn content in liver0.70.72.01.4-0.6-0.6-0.7-0.8-0.7-0.7-0.7-1.0-1.0
Bone: minimum diameter1.32.411.0-3.30.81.11.01.11.41.11.21.61.4
Time in familiar zone, hab. session 10.20.20.2-0.40.40.40.40.40.40.40.40.50.5
Time in novel zone, hab. session 10.00.00.10.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.2-0.1
Total zone transitions, hab. session 11.92.63.5-0.71.61.71.71.71.81.61.61.91.7
Total locomotion distance, hab. session 12.23.14.1-1.91.41.71.61.61.91.71.62.01.8
Locomotion velocity, hab. session 11.72.43.2-1.31.41.61.51.51.71.51.51.81.6
Time in familiar zone, hab. session 20.10.10.2-0.5-0.40.0-0.3-0.3-0.4-0.0-0.0-0.2-0.3
Time in novel zone, hab. session 20.10.10.40.60.40.10.40.40.50.10.10.30.3
Total zone transitions, hab. session 20.10.10.10.10.30.30.30.30.30.20.20.30.3
Total locomotion distance, hab. session 20.30.40.7-0.80.50.60.60.60.70.50.50.70.7
Locomotion velocity, hab. session 20.30.40.6-0.80.50.50.60.60.70.50.50.70.7
Novel to familiar place preference ratio1.41.52.0-1.11.11.31.21.21.11.21.21.41.3
Novelty place preference0.80.81.1-1.00.80.90.90.90.80.90.91.11.0
Time in novel zone, NPP test0.91.01.4-0.81.01.11.01.00.91.01.01.21.1
Total zone transitions, NPP test0.00.10.30.60.20.10.20.20.0-0.1-0.10.10.1
Total locomotion distance, NPP test0.70.92.1-1.40.70.90.80.90.90.80.81.11.0
Locomotion velocity, NPP test0.60.92.8-1.70.60.80.80.80.90.70.71.10.9
Intraocular pressure0.50.71.00.5-0.8-0.5-0.9-0.9-1.0-0.8-0.8-1.0-0.9
Delta distance traveled before/after self-admin0.00.00.10.40.1-0.00.00.0-0.0-0.0-0.0-0.0-0.1
Delta ambulatory time before/after self-admin0.00.00.1-0.20.20.20.20.20.20.20.20.20.1
Parametrial fat weight0.10.30.40.5-0.4-0.6-0.4-0.5-0.5-0.5-0.6-0.6-0.5
Pavlov. Cond. lever latency0.30.30.50.70.60.60.60.60.60.50.50.50.5
Pavlov. Cond. magazine entry latency0.10.10.20.5-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.3-0.3
Pavlov. Cond. change in total contacts0.10.10.2-0.0-0.4-0.4-0.4-0.4-0.3-0.4-0.4-0.4-0.4
Pavlov. Cond. index score0.10.10.2-0.1-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4
Pavlov. Cond. latency score0.10.20.2-0.3-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4
Pavlov. Cond. lever contacts0.80.91.1-1.0-1.1-1.0-1.0-1.0-1.0-0.9-1.0-0.9-0.9
Pavlov. Cond. magazine entry number0.00.00.0-0.20.0-0.1-0.0-0.0-0.10.00.10.00.1
Pavlov. Cond. intertrial magazine entries0.50.60.70.30.80.70.80.80.80.70.80.80.9
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.2-0.6-0.5-0.6-0.6-0.5-0.6-0.6-0.5-0.6
Pavlov. Cond. response bias0.20.30.4-0.2-0.6-0.5-0.6-0.5-0.5-0.6-0.6-0.5-0.6
Pavlov. Cond. lever latency1.11.54.82.21.31.31.11.10.81.11.10.81.0
Pavlov. Cond. magazine entry latency4.15.05.7-1.6-2.4-2.4-2.3-2.3-2.1-2.3-2.3-2.2-2.3
Pavlov. Cond. change in total contacts1.01.58.4-2.9-1.2-1.0-1.0-1.0-0.6-0.9-0.9-0.6-0.7
Pavlov. Cond. index score2.12.84.3-2.1-1.8-1.7-1.7-1.6-1.4-1.6-1.7-1.4-1.5
Pavlov. Cond. latency score2.33.13.8-1.9-1.9-1.9-1.8-1.8-1.6-1.7-1.7-1.5-1.7
Pavlov. Cond. lever contacts1.11.55.3-2.3-1.2-1.1-1.1-1.1-0.8-1.1-1.1-0.7-0.9
Pavlov. Cond. magazine entry number2.02.53.01.21.71.71.61.61.51.61.71.51.6
Pavlov. Cond. intertrial magazine entries0.30.41.11.0-0.4-0.4-0.5-0.5-0.7-0.6-0.6-0.7-0.6
Pavlov. Cond. lever-magazine prob. diff.2.23.04.5-2.1-1.9-1.8-1.7-1.7-1.5-1.7-1.7-1.4-1.6
Pavlov. Cond. response bias1.62.26.4-2.5-1.6-1.4-1.4-1.4-1.0-1.4-1.4-1.0-1.2
Time in closed arm before self-admin0.20.30.4-0.10.50.60.60.60.60.60.60.60.5
Time in closed arm after self-admin1.11.21.40.0-1.1-1.2-1.1-1.1-1.2-1.1-1.1-1.2-1.2
Time in open arm before self-admin1.21.31.5-1.0-1.2-1.2-1.2-1.2-1.2-1.2-1.2-1.1-1.1
Time in open arm after self-admin0.30.32.3-1.50.10.30.20.20.30.30.30.50.5
Bone: periosteal estimation0.30.65.0-2.20.00.30.20.20.40.30.30.50.4
Bone: periosteal perimeter0.20.43.6-1.9-0.00.30.10.10.30.20.30.40.3
Bone: post-yield work0.50.71.2-1.10.50.90.60.60.81.11.10.80.7
Progressive ratio test 1 active lever presses2.63.23.8-0.7-2.0-1.9-1.9-1.9-1.8-1.8-1.8-1.8-1.8
Progressive ratio test 1 breakpoint2.63.23.9-0.9-2.0-1.9-1.9-1.9-1.8-1.8-1.8-1.8-1.8
Progressive ratio test 1 inactive lever presses2.23.13.7-0.8-1.9-1.9-1.9-1.9-1.8-1.8-1.8-1.8-1.8
Progressive ratio test 2 active lever presses2.63.13.70.3-1.8-1.9-1.8-1.8-1.9-1.9-1.9-1.9-1.9
Progressive ratio test 2 breakpoint2.42.73.30.3-1.7-1.8-1.7-1.7-1.7-1.7-1.7-1.8-1.7
Progressive ratio test 2 inactive lever presses3.04.85.4-0.8-2.3-2.3-2.3-2.3-2.3-2.3-2.3-2.3-2.3
Incentive Sensitization - Responses0.40.60.70.7-0.6-0.8-0.7-0.7-0.8-0.8-0.8-0.9-0.8
Incentive Sensitization - Breakpoint0.30.40.60.8-0.4-0.6-0.5-0.5-0.6-0.6-0.6-0.7-0.6
Sum of active levers in priming session hrs 5-65.95.56.5-0.22.42.52.42.42.52.52.52.62.4
Progressive ratio0.91.31.61.21.31.21.21.21.01.21.01.11.1
Food seeking constrained by brief footshock0.30.42.8-1.70.10.40.30.30.40.40.30.50.4
Seeking ratio, punishment vs. effort1.42.02.6-1.6-1.6-1.5-1.5-1.5-1.1-1.4-1.3-1.3-1.4
Retroperitoneal fat weight0.10.31.61.3-0.2-0.5-0.3-0.3-0.5-0.4-0.4-0.5-0.4
Reaction time number correct0.00.00.0-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.1-0.1
Reaction time mean minus median0.30.70.9-0.6-0.9-0.8-0.9-0.9-0.7-0.9-0.9-0.9-0.9
Reaction time mean minus median AUC0.82.02.3-0.8-1.5-1.4-1.5-1.5-1.4-1.5-1.5-1.5-1.5
Reaction time num false alarms0.40.51.41.20.80.30.80.80.80.50.50.60.6
Reaction time num false alarms AUC0.50.82.11.51.00.50.90.91.00.70.70.80.7
Reaction time trials correct on left0.00.00.0-0.2-0.2-0.1-0.2-0.2-0.1-0.1-0.1-0.1-0.1
Reaction time trials on left0.00.00.0-0.2-0.2-0.1-0.2-0.2-0.2-0.1-0.1-0.1-0.2
Reaction time mean0.60.91.20.2-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.1-1.0
Reaction time mean AUC1.21.82.40.3-1.4-1.4-1.4-1.4-1.5-1.4-1.4-1.5-1.4
Median of all reaction times0.40.60.90.6-0.7-0.8-0.8-0.8-0.9-0.8-0.8-0.9-0.8
Reaction time omissions0.00.00.30.5-0.0-0.2-0.1-0.1-0.0-0.2-0.2-0.2-0.2
Reaction time false alarm rate0.30.41.81.40.70.20.60.60.70.40.40.40.3
Reaction time premature initiation rate0.10.20.2-0.00.40.50.40.40.50.30.40.40.4
Reaction time premature initiations0.10.10.2-0.10.30.40.30.30.40.30.30.40.3
Std. dev. reaction times0.81.41.7-0.5-1.3-1.1-1.3-1.3-1.2-1.2-1.2-1.3-1.3
Reaction time trials completed0.00.00.0-0.2-0.2-0.1-0.2-0.2-0.2-0.1-0.1-0.1-0.2
Reaction time trials AUC0.00.00.0-0.1-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.1
Run reversals in cocaine runway, females2.22.22.70.4-1.5-1.6-1.5-1.5-1.6-1.6-1.6-1.7-1.6
Run reversals in cocaine runway, males0.40.40.80.90.70.60.70.60.90.60.60.50.6
Latency to leave start box in cocaine runway0.00.00.10.3-0.1-0.1-0.1-0.1-0.0-0.1-0.1-0.2-0.1
Latency to leave start box in cocaine runway, F0.10.10.20.50.40.40.30.30.30.30.30.30.3
Latency to leave start box in cocaine runway, M0.20.20.20.1-0.4-0.5-0.5-0.4-0.3-0.5-0.5-0.4-0.5
Std. dev. time between licks in bursts0.20.30.6-0.70.40.40.50.50.60.60.60.60.5
Total sessions with >9 infusions0.40.40.50.50.60.70.70.70.70.70.70.70.7
Short access day 1 total inactive lever presses1.31.72.0-0.8-1.4-1.3-1.4-1.4-1.3-1.3-1.3-1.3-1.3
Short access day 10 total inactive lever presses1.02.53.0-1.5-1.7-1.6-1.7-1.6-1.6-1.6-1.6-1.5-1.6
Short access day 1 total infusions0.40.61.0-1.0-0.8-0.7-0.8-0.8-0.7-0.7-0.7-0.6-0.7
Short access day 10 total infusions0.20.30.30.1-0.6-0.5-0.5-0.5-0.5-0.5-0.5-0.6-0.5
Short access total infusions0.20.30.30.2-0.6-0.6-0.5-0.5-0.6-0.6-0.6-0.6-0.6
Short access day 1 locomotion0.50.71.21.10.90.80.80.80.70.70.70.70.7
Short access day 10 total locomotion0.10.10.8-0.9-0.10.20.10.10.20.20.20.30.2
Short access total locomotion0.20.30.40.10.50.60.60.60.60.60.60.60.6
One hour access (0.3 mA shock)0.40.50.7-0.6-0.8-0.7-0.8-0.8-0.7-0.7-0.7-0.7-0.7
Compulsive drug intake2.53.03.8-1.71.51.81.61.61.81.81.81.91.8
One hour access (shock baseline)1.32.02.40.3-1.4-1.5-1.4-1.5-1.5-1.5-1.5-1.5-1.5
Social response proportion1.11.25.2-2.3-1.1-0.8-1.0-1.0-1.0-0.7-0.7-0.7-0.7
Social responses0.81.01.3-0.2-1.0-1.1-1.1-1.1-1.1-1.0-1.0-1.1-0.9
Social time0.50.60.9-0.60.70.90.70.70.90.90.90.80.7
Soleus weight1.75.16.21.52.52.32.52.52.22.22.22.32.4
Bone: stiffness0.30.52.3-1.50.30.40.40.50.80.50.40.70.6
Tibialis anterior weight0.93.14.00.21.91.61.91.92.01.71.82.01.9
Time to tail flick, vehicle, before self-admin1.41.42.0-0.2-1.2-1.3-1.2-1.2-1.2-1.2-1.2-1.3-1.4
Time to tail flick, vehicle, after self-admin2.33.13.5-0.5-1.8-1.9-1.9-1.9-1.8-1.8-1.8-1.8-1.8
Time to tail flick, test, before self-admin0.00.00.20.40.20.10.10.10.10.10.10.0-0.0
Time to tail flick, test, after self-admin0.20.20.20.2-0.4-0.5-0.4-0.5-0.5-0.5-0.5-0.5-0.2
Delta time to tail flick, vehicle, before/after SA0.40.40.5-0.5-0.7-0.6-0.7-0.7-0.6-0.6-0.6-0.6-0.5
Delta time to tail flick, test, before/after SA0.20.20.3-0.1-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.5-0.3
Tibia length1.43.96.0-2.5-2.1-1.9-2.0-2.0-1.7-1.9-1.9-1.7-1.8
Ambulatory time before self-admin0.20.32.0-1.4-0.5-0.3-0.4-0.4-0.3-0.3-0.3-0.2-0.2
Ambulatory time after self-admin0.60.63.0-1.7-0.8-0.6-0.7-0.7-0.6-0.6-0.6-0.4-0.5
Bone: tissue strength0.70.74.7-2.2-0.7-0.4-0.6-0.6-0.6-0.3-0.3-0.3-0.4
Total heroin consumption4.14.86.3-1.22.02.42.22.22.32.32.32.52.2
Bone: trabecular number0.30.40.8-0.3-0.7-0.5-0.7-0.7-0.9-0.5-0.6-0.7-0.7
Bone: trabecular spacing0.40.52.1-1.50.30.60.40.40.70.50.50.70.6
Bone: trabecular thickness1.21.52.00.2-1.1-1.4-1.2-1.2-1.4-1.3-1.3-1.3-1.2
Bone: trabecular tissue density1.21.73.71.91.41.21.31.21.21.21.21.01.1
Water consumed over 24 hours0.81.11.6-1.1-1.1-1.3-1.1-1.1-0.7-1.1-1.1-1.0-1.0
Number of responses in last shaping day0.20.20.6-0.8-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.4