Hub : Genes

Acot11

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA mRNA stability Acot11 0.11 0.06 1.8e-04 0.05 0.08 0.07 0.06 3.6e-03 3.5e-04 6.0e-04 9.4e-04
2 PL mRNA stability Acot11 0.06 0.06 8.2e-05 0.02 0.02 0.03 0.03 1.0e-03 2.6e-03 2.8e-04 3.0e-04
3 pVTA gene expression Acot11 0.27 0.16 1.6e-07 0.07 0.15 0.12 0.11 3.7e-04 7.4e-07 8.0e-06 1.6e-05
4 LHb mRNA stability Acot11 0.3 0.13 2.7e-05 0.13 0.16 0.12 0.17 6.9e-04 1.2e-04 9.4e-04 5.9e-05
5 NAcc gene expression Acot11 0.12 0.05 0.0e+00 0.13 0.1 0.14 0.12 3.6e-15 9.8e-12 3.5e-16 2.9e-13
6 Brain mRNA stability Acot11 0.14 0.06 1.1e-16 0.16 0.16 0.16 0.16 1.2e-14 7.5e-15 4.1e-15 1.6e-14
7 BLA gene expression Acot11 0.09 0.06 1.7e-03 0.06 0.03 0.04 0.05 3.3e-04 1.6e-02 2.7e-03 9.0e-04
8 NAcc mRNA stability Acot11 0.06 0.04 3.0e-06 0.04 0.04 0.04 0.04 3.9e-05 6.6e-06 1.9e-05 1.4e-05
9 PL gene expression Acot11 0.04 0.03 4.0e-05 0.05 0.03 0.03 0.04 7.0e-06 1.1e-04 4.3e-04 7.2e-05
10 PL intron excision ratio chr5_121527746_121528459 0.02 0.02 6.9e-03 0.02 0.02 0.01 0.01 5.4e-03 5.3e-03 2.8e-02 7.3e-03
11 LHb gene expression Acot11 0.32 0.15 1.8e-04 0.13 0.07 0.03 0.06 6.1e-04 1.1e-02 6.2e-02 1.2e-02
12 Brain gene expression Acot11 0.17 0.07 1.2e-13 0.16 0.14 0.14 0.16 8.3e-15 8.7e-13 2.7e-13 2.9e-14
13 BLA mRNA stability Acot11 0.12 0.06 9.6e-06 0.08 0.08 0.06 0.09 4.6e-05 4.7e-05 4.9e-04 1.5e-05
14 Brain isoform ratio NM_001271383.1 0.05 0.03 2.9e-04 0.03 0.01 0.02 0.02 1.3e-03 1.4e-02 4.7e-03 1.2e-02
15 Eye gene expression Acot11 0.52 0.22 4.1e-03 0.11 0.08 0.06 0.14 8.5e-03 2.4e-02 3.9e-02 3.4e-03
16 OFC mRNA stability Acot11 0.2 0.11 3.7e-03 0.03 0.01 -0 0.02 6.6e-02 1.5e-01 3.8e-01 9.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.50.83.2-0.31.0-0.1-0.20.4-0.40.90.50.9-0.60.70.70.6-1.5-1.8-1.5
Area under the delay curve1.01.13.61.0-1.90.41.1-1.2-0.5-1.30.5-1.2-0.2-1.3-1.30.1-0.81.3-0.8
BMI with tail0.30.92.4-1.30.5-1.6-1.00.91.30.5-1.30.51.30.60.6-1.40.30.0-0.4
BMI without tail0.20.53.20.4-0.10.50.6-0.3-0.6-0.20.70.1-0.8-0.4-0.40.6-1.0-0.8-1.8
Body weight0.10.61.6-0.80.6-1.2-0.40.31.1-0.1-1.1-0.21.3-0.4-0.3-1.30.50.80.0
Weight adjusted by age0.40.42.1-0.4-0.2-0.5-0.60.50.60.2-0.60.20.70.30.3-0.61.40.51.3
Bone surface0.10.31.40.11.20.30.1-0.1-0.30.10.20.1-0.40.00.00.3-1.0-0.5-0.9
Bone volume0.20.31.1-0.51.1-0.5-0.40.50.30.5-0.20.50.20.40.4-0.2-0.8-0.8-0.6
Breakpoint value in progressive ratio session0.20.31.00.30.00.40.4-0.5-0.6-0.50.6-0.4-0.5-0.2-0.20.6-0.5-0.6-1.0
Number of licking bursts0.40.42.1-0.1-0.2-0.5-0.0-0.00.5-0.3-0.5-0.50.8-0.6-0.6-0.81.01.41.0
Context. condit. distance diff. score1.01.25.7-0.91.4-0.4-0.71.00.11.20.11.4-0.31.41.40.4-0.7-2.4-0.7
Locomotion velocity, session 11.11.23.01.1-0.61.21.1-1.1-1.3-0.61.4-0.8-1.3-0.6-0.61.3-1.7-0.3-1.6
Locomotion distance, session 10.00.00.1-0.00.2-0.2-0.0-0.2-0.10.00.10.00.1-0.1-0.10.0-0.4-0.1-0.0
Locomotion velocity, session 20.70.81.41.0-0.61.10.8-0.9-1.1-0.31.1-0.5-1.1-0.5-0.51.0-1.2-0.1-1.1
Locomotion distance, session 20.30.41.1-0.70.5-0.9-0.70.50.80.5-0.90.41.00.30.3-1.00.30.50.7
Locomotion velocity, session 30.20.21.9-0.1-0.1-0.20.20.0-0.10.10.10.1-0.1-0.0-0.0-0.1-1.4-0.6-1.2
Locomotion distance, session 30.20.30.6-0.60.7-0.6-0.40.70.40.6-0.30.70.30.50.5-0.2-0.2-0.7-0.1
Stereotopy head waving bouts, day 30.30.30.80.2-0.6-0.20.3-0.50.2-0.8-0.3-0.80.5-0.9-0.9-0.60.10.90.2
Stereotopy head waving duration, day 30.20.20.50.2-0.7-0.10.3-0.50.0-0.5-0.1-0.70.3-0.7-0.7-0.3-0.00.70.0
Locomotion velocity, session 70.80.81.8-1.00.4-0.9-1.11.20.71.4-0.61.30.51.21.2-0.5-0.1-0.9-0.3
Locomotion distance, session 71.72.15.0-1.51.2-0.9-1.61.70.82.1-0.62.10.32.12.1-0.2-0.3-2.2-0.2
Stereotopy head waving bouts, day 71.31.52.31.3-0.61.11.5-1.5-1.1-1.31.0-1.5-0.9-1.4-1.40.7-1.30.9-1.3
Stereotopy head waving duration, day 72.12.53.91.7-1.21.32.0-1.9-1.3-1.71.3-1.9-1.1-1.8-1.80.9-1.81.2-1.7
Locomotion velocity, session 80.80.94.40.7-0.70.70.7-0.5-0.90.01.0-0.1-1.1-0.0-0.00.9-2.1-0.6-2.0
Locomotion distance, session 81.11.53.6-1.41.9-1.2-1.21.30.71.5-0.61.60.51.41.4-0.4-0.8-1.9-0.4
Degree of sensitization distance1.01.02.1-1.10.5-0.8-1.31.10.81.3-0.71.30.51.41.4-0.40.4-1.20.4
Degree of sensitization stereotypy1.31.52.51.3-0.61.11.5-1.5-1.0-1.40.9-1.6-0.8-1.5-1.50.6-1.11.1-1.2
Conditioned locomotion0.10.10.7-0.3-0.3-0.5-0.20.30.40.2-0.30.30.30.10.1-0.4-0.8-0.0-0.6
Cocaine response after cond. corrected1.51.65.2-1.52.3-1.4-1.21.31.31.1-1.31.21.41.01.0-1.21.1-0.31.2
Cocaine response after cond. not corrected2.32.69.1-1.73.0-1.4-1.51.61.51.4-1.61.41.61.11.1-1.41.9-0.31.9
Cocaine response before conditioning0.20.31.0-0.20.90.2-0.40.40.30.6-0.50.40.10.30.3-0.21.00.10.9
Saline control response0.40.53.1-0.41.8-0.1-0.10.5-0.11.00.20.9-0.20.60.60.4-0.3-1.0-0.1
Bone: connectivity density0.61.03.90.40.50.70.5-0.3-1.00.31.00.3-1.20.20.21.1-1.9-1.4-2.0
Bone: cortical apparent density0.91.22.81.0-0.51.20.9-0.8-1.5-0.31.7-0.2-1.6-0.1-0.11.6-1.5-1.0-1.5
Bone: cortical area0.81.22.2-1.40.8-1.5-1.31.21.50.9-1.40.81.40.70.7-1.40.6-0.10.7
Bone: cortical porosity1.82.05.01.0-0.00.51.5-1.8-0.6-2.20.4-2.20.3-2.2-2.20.01.01.41.3
Bone: cortical porosity2.93.27.81.6-0.71.12.0-2.4-1.1-2.80.9-2.8-0.2-2.8-2.80.50.41.80.8
Bone: cortical thickness1.72.86.5-2.10.0-2.6-1.91.72.30.8-2.20.92.40.90.9-2.41.10.21.3
Bone: cortical thickness1.11.32.4-1.51.6-1.4-1.01.11.40.8-1.30.91.40.70.7-1.30.8-0.80.8
Bone: cortical tissue density1.01.43.01.1-0.51.31.0-0.8-1.6-0.31.7-0.2-1.7-0.1-0.11.7-1.6-1.0-1.6
Condit. Reinf. active minus inactive responses0.91.03.7-1.01.9-0.6-1.21.20.81.4-1.01.20.51.21.2-0.6-0.1-0.7-0.1
Condit. Reinf. active-inactive response ratio1.51.65.6-1.32.4-0.8-1.41.51.11.5-1.31.40.71.41.4-0.90.1-0.90.1
Condit. Reinf. active responses0.40.41.0-0.50.7-0.5-0.60.50.80.4-1.00.30.80.20.2-0.90.80.80.8
Condit. Reinf. inactive responses0.91.13.91.0-2.00.40.9-1.1-0.4-1.20.4-1.2-0.0-1.3-1.30.10.71.80.7
Incentive salience index mean1.31.64.5-1.32.1-1.0-1.41.41.31.3-1.51.21.11.11.1-1.20.8-0.20.8
Condit. Reinf. lever presses0.70.92.0-1.11.4-1.0-1.01.11.20.8-1.40.81.10.60.6-1.10.80.00.7
Condit. Reinf. active minus inactive responses1.61.94.5-1.51.5-0.8-1.51.81.12.1-1.12.10.51.91.9-0.6-0.1-1.2-0.1
Condit. Reinf. active-inactive response ratio1.92.04.6-1.21.8-0.4-1.41.60.62.1-0.52.2-0.22.12.1-0.0-0.8-1.8-1.0
Condit. Reinf. active responses1.31.93.8-1.51.6-1.1-1.51.81.21.9-1.31.90.81.61.6-0.90.2-1.10.3
Condit. Reinf. inactive responses0.70.82.1-0.90.3-1.1-0.80.81.10.6-1.10.51.30.20.2-1.11.40.31.5
Condit. Reinf. lever presses0.30.41.70.70.01.00.4-0.2-0.60.30.40.1-0.8-0.1-0.10.6-1.30.5-1.1
Condit. Reinf. lever reinforcers received0.91.32.5-1.21.2-0.9-1.21.51.11.6-1.21.60.71.31.3-0.80.0-0.60.2
Conditioned reinforcement - actives1.61.62.5-1.50.5-1.6-1.51.41.61.1-1.60.81.51.11.1-1.51.30.40.9
Conditioned reinforcement - inactives0.20.20.4-0.40.6-0.5-0.20.10.5-0.1-0.6-0.00.7-0.1-0.1-0.70.40.40.2
Conditioned locomotion1.01.23.6-1.20.5-0.8-1.01.20.71.9-0.51.60.31.71.7-0.30.1-1.3-0.2
Patch foraging indifference point 0 sec0.10.10.5-0.20.7-0.0-0.30.30.10.3-0.30.4-0.00.60.6-0.0-0.30.3-0.1
Patch foraging indifference point AUC0.40.51.4-0.50.4-0.3-0.70.80.21.0-0.01.0-0.11.01.00.1-0.0-1.2-0.6
Delay disc. indifference point, 0s delay1.11.23.21.2-1.80.71.4-1.4-0.9-1.21.0-1.4-0.6-1.3-1.30.6-0.70.9-0.8
Delay disc. indifference point, 16s delay0.50.61.4-0.4-0.7-0.9-0.1-0.00.9-0.5-0.9-0.31.2-0.5-0.5-1.20.41.20.8
Delay disc. indifference point, 2s delay0.40.43.50.5-1.90.20.6-0.6-0.4-0.60.5-0.6-0.4-0.3-0.30.4-0.60.3-0.8
Delay disc. indifference point, 24s delay0.60.61.50.8-1.20.50.7-0.7-0.3-0.70.2-0.5-0.3-0.8-0.80.0-1.01.0-1.2
Delay disc. indifference point, 4s delay1.21.26.41.0-2.50.21.1-1.2-0.5-1.20.7-1.2-0.3-1.3-1.30.2-0.81.1-1.0
Delay disc. indifference point, 8s delay0.30.30.80.5-0.90.20.6-0.6-0.1-0.80.1-0.80.0-0.8-0.8-0.1-0.20.9-0.3
Indifference point function ln k0.10.10.4-0.40.6-0.4-0.00.20.30.3-0.40.20.5-0.1-0.1-0.40.50.00.7
Indifference point function log k0.10.10.4-0.40.6-0.4-0.00.20.30.3-0.40.20.5-0.1-0.1-0.40.50.00.7
Patch foraging total patch changes 0 sec0.10.10.7-0.00.80.1-0.10.1-0.10.4-0.10.3-0.20.40.40.2-0.50.1-0.4
Patch foraging total patch changes 12 sec1.31.74.01.5-0.31.71.3-1.1-1.6-0.51.6-0.5-1.8-0.5-0.51.6-1.9-0.3-2.0
Patch foraging total patch changes 18 sec0.40.62.7-0.71.7-0.3-0.80.80.30.9-0.30.90.11.11.1-0.1-0.1-0.7-0.2
Patch foraging total patch changes 24 sec0.30.31.4-0.2-0.0-0.4-0.30.30.40.0-0.50.20.60.00.1-0.51.21.01.1
Patch foraging total patch changes 6 sec0.10.10.3-0.20.4-0.2-0.40.40.20.5-0.20.40.10.60.6-0.10.20.10.0
Patch foraging time to switch 0 sec2.64.16.12.5-1.42.42.4-2.4-2.1-2.42.0-2.2-1.9-2.0-2.01.8-1.71.2-1.3
Patch foraging water rate 0 sec1.83.04.6-2.11.3-2.1-2.02.02.01.8-1.91.72.01.41.4-1.91.4-0.31.3
Patch foraging water rate 12 sec3.14.88.1-2.60.5-2.9-2.62.62.72.1-2.61.92.61.71.7-2.52.00.11.6
Patch foraging water rate 18 sec0.30.43.30.5-1.8-0.10.6-0.4-0.0-0.30.2-0.30.0-0.7-0.7-0.0-0.50.8-0.7
Patch foraging water rate 24 sec0.10.10.4-0.4-0.0-0.6-0.20.20.4-0.1-0.20.20.6-0.1-0.1-0.40.30.10.3
Patch foraging water rate 6 sec0.71.02.2-0.7-0.4-1.2-0.70.61.30.0-1.3-0.11.5-0.1-0.1-1.51.51.41.4
Seeking ratio, delayed vs. immediate footshock5.46.310.2-3.22.4-2.9-2.92.92.62.4-2.42.62.32.72.7-2.12.0-2.01.6
Distance traveled before self-admin2.93.15.6-2.11.6-1.8-1.92.21.52.4-1.32.41.22.12.1-1.11.1-1.60.7
Distance traveled after self-admin4.14.57.3-2.70.7-2.7-2.52.52.42.2-2.32.32.12.42.4-2.11.2-0.81.2
Extensor digitorum longus weight1.35.29.0-3.02.5-3.0-2.62.62.22.3-1.92.12.22.32.3-1.81.6-1.91.8
Bone: elastic displacement4.34.99.4-2.32.8-1.4-2.62.71.33.0-1.23.00.73.13.1-0.60.7-2.60.8
Bone: elastic work2.73.56.8-2.11.9-1.6-2.22.41.32.6-1.02.60.82.52.5-0.70.5-2.30.6
Bone: endosteal estimation0.30.75.80.12.40.80.10.0-0.70.50.50.3-0.80.30.31.0-0.3-1.2-0.3
Bone: endosteal perimeter0.30.61.50.90.81.20.8-0.9-1.0-0.50.8-0.7-0.9-0.6-0.61.0-0.40.2-0.3
Epididymis fat weight0.61.53.41.3-1.80.91.3-1.4-0.7-1.60.7-1.7-0.5-1.5-1.50.4-0.31.7-0.3
Delta time in closed arm before/after self-admin4.24.09.3-2.21.8-1.5-2.42.41.12.6-0.72.50.62.82.8-0.31.1-3.01.1
Delta time in open arm before/after self-admin1.71.73.01.6-0.51.41.6-1.5-1.0-1.50.7-1.5-0.8-1.7-1.70.7-0.71.6-0.8
Diff in mean of infusions in LGA sessions0.20.21.6-0.21.3-0.20.2-0.2-0.1-0.10.1-0.20.2-0.4-0.40.00.5-0.60.0
Delay discount exponential model param1.11.23.8-1.01.9-0.4-1.21.20.51.3-0.61.20.31.31.3-0.10.9-1.20.9
Extinction: sum of active levers before priming0.10.11.0-0.30.8-0.30.0-0.1-0.2-0.20.5-0.2-0.00.10.10.30.1-1.00.2
Active lever presses in extinction session 61.51.53.2-1.71.1-1.8-1.31.41.40.7-1.31.11.41.01.0-1.30.5-1.2-0.0
Bone: final force0.00.00.00.1-0.10.0-0.1-0.1-0.1-0.10.1-0.1-0.0-0.1-0.10.1-0.1-0.00.1
Bone: final moment0.00.00.1-0.2-0.0-0.2-0.40.20.10.2-0.10.10.20.10.1-0.10.1-0.10.3
Food consumed during 24 hour testing period0.30.31.10.4-0.70.20.3-0.30.2-0.1-0.4-0.20.1-0.5-0.5-0.4-1.01.0-1.0
Glucose0.20.31.0-0.30.3-0.0-0.40.60.00.70.11.0-0.30.91.00.3-0.4-0.9-0.2
Heart weight1.01.42.1-1.41.3-1.4-1.31.41.41.4-1.41.11.30.90.9-1.20.7-0.30.9
Delay discount hyperbolic model param1.31.34.9-1.12.2-0.5-1.31.30.61.4-0.71.30.41.41.4-0.31.0-1.20.9
Intermittent access intake day 1-15 change0.50.51.6-0.2-0.8-0.3-0.70.60.7-0.1-0.7-0.10.50.20.2-0.61.21.21.2
Intermittent access intake escalation0.70.72.0-0.5-0.4-0.5-1.10.90.90.2-0.90.20.70.60.6-0.71.31.11.4
Intermittent access intake escalation 20.30.31.50.6-1.20.70.3-0.2-0.3-0.30.3-0.4-0.5-0.2-0.20.4-0.30.8-0.1
Intermitt. access day 1 inactive lever presses3.13.37.8-2.02.5-1.9-2.21.71.70.8-1.71.01.91.41.5-1.52.8-0.62.5
Intermitt. access day 15 inactive lever presses0.30.32.4-0.51.5-0.4-0.30.10.40.1-0.50.00.6-0.0-0.0-0.50.6-0.30.5
Intermitt. access escalation Index0.40.41.70.4-1.30.10.2-0.20.1-0.7-0.2-0.40.2-0.8-0.7-0.30.51.30.1
Intermittent access day 1 total infusions0.10.20.5-0.40.1-0.5-0.10.10.50.2-0.6-0.00.60.0-0.0-0.7-0.10.2-0.7
Intermittent access day 15 total infusions0.50.61.2-0.7-0.4-0.8-1.00.81.10.4-1.10.20.90.60.6-1.00.90.80.4
Intermittent access terminal intake (last 3 days)0.20.30.5-0.5-0.5-0.4-0.70.60.60.7-0.60.40.30.70.7-0.50.20.2-0.3
Intermittent access total infusions0.10.20.3-0.4-0.4-0.5-0.30.20.50.3-0.60.10.50.30.3-0.60.30.4-0.3
Intermittent access day 1 locomotion0.10.10.3-0.20.6-0.30.0-0.10.30.1-0.5-0.00.5-0.2-0.2-0.60.00.5-0.4
Intermittent access day 15 total locomotion0.10.10.40.3-0.60.30.2-0.3-0.1-0.20.1-0.3-0.2-0.0-0.10.10.10.6-0.1
Intermittent access total locomotion0.10.10.40.1-0.0-0.10.1-0.20.1-0.1-0.3-0.40.2-0.2-0.3-0.30.20.7-0.1
Intermittent access standard deviation2.32.43.9-1.70.1-1.9-1.91.92.01.5-1.91.31.71.41.4-1.81.40.40.9
Left kidney weight6.819.235.1-5.62.7-5.9-5.14.85.33.5-4.93.35.23.73.7-4.74.3-0.83.8
Right kidney weight3.610.221.9-4.11.0-4.7-3.53.34.12.0-3.71.94.22.32.3-3.83.2-0.13.1
Cocaine induced anxiety0.10.10.30.10.50.5-0.00.1-0.10.6-0.00.5-0.40.40.40.2-0.5-0.3-0.5
Post-drug Anxiety0.20.20.70.30.50.60.1-0.1-0.60.20.50.4-0.70.30.30.6-0.4-0.8-0.4
Baseline Anxiety0.50.62.4-0.70.4-1.0-0.70.40.6-0.2-0.40.11.00.10.1-0.61.5-0.11.5
Tail length0.41.11.91.20.11.41.3-1.2-1.3-0.91.3-0.8-1.2-1.2-1.21.2-0.5-0.3-0.7
Length with tail0.00.10.50.10.70.10.3-0.3-0.1-0.20.1-0.40.0-0.5-0.50.10.20.20.2
Length without tail0.30.61.7-0.60.6-1.0-0.30.00.9-0.2-0.9-0.51.3-0.3-0.3-1.10.91.01.3
Times rat made contact with spout0.40.50.9-0.80.9-1.0-0.60.70.70.9-0.60.60.80.50.5-0.70.8-0.20.8
Lifetime Intake0.20.20.4-0.4-0.2-0.5-0.40.20.60.3-0.70.00.60.30.2-0.70.50.60.0
Liver weight, left0.81.22.1-1.40.8-1.4-1.41.31.41.0-1.31.11.21.00.9-1.20.5-0.7-0.0
Liver weight, right0.20.32.2-0.61.5-0.6-0.20.20.30.1-0.20.00.50.00.0-0.30.6-0.70.2
Locomotor activity0.50.71.8-0.81.0-0.4-1.01.00.31.1-0.21.30.11.31.30.00.3-1.00.6
Locomotor testing distance2.13.48.2-1.81.7-1.0-2.12.40.92.7-0.82.90.32.72.7-0.30.8-2.10.9
Locomotor testing rearing1.01.53.7-1.11.4-0.5-1.21.40.41.7-0.31.8-0.11.91.90.10.2-1.80.0
Locomotion in novel chamber1.11.33.6-1.3-0.2-1.7-0.90.91.80.2-1.70.21.80.20.2-1.90.60.80.7
Locomotion in novel chamber post-restriction0.40.41.6-0.8-0.4-1.3-0.70.40.90.1-0.8-0.11.10.10.1-1.10.10.3-0.1
Fecal boli incidents, locomotor time 10.10.10.70.10.70.10.4-0.3-0.1-0.30.1-0.20.1-0.4-0.4-0.10.3-0.20.8
Change in fecal boli incidents, locomotor task1.21.11.91.2-1.11.01.2-1.3-1.0-1.31.0-1.4-0.9-1.1-1.11.0-0.80.6-0.9
Time >=10cm from walls, locomotor time 10.70.73.8-0.11.30.40.10.1-0.60.40.60.4-0.80.80.80.9-0.9-2.0-1.0
Bouts of movement, locomotor time 11.71.93.81.50.11.11.9-1.8-1.5-1.61.5-1.6-0.9-1.9-1.91.1-0.90.5-0.4
Total resting periods, locomotor time 12.02.24.41.60.11.22.0-1.9-1.5-1.81.5-1.8-0.9-2.1-2.11.1-0.70.9-0.1
Rest time, locomotor task time 10.30.40.90.70.50.90.6-0.5-0.8-0.20.7-0.3-0.7-0.5-0.50.8-0.4-0.10.3
Distance moved, locomotor task time 10.50.51.0-0.8-0.6-0.8-1.00.90.80.7-0.60.60.50.90.9-0.6-0.3-0.4-0.9
Vertical activity count, locomotor time 10.90.91.8-1.0-1.0-1.3-1.31.11.20.6-1.00.61.10.80.8-1.10.80.20.4
Time >=10cm from walls, locomotor time 20.60.62.0-0.91.1-0.6-0.50.80.50.8-0.40.70.21.11.1-0.2-0.2-1.4-0.4
Bouts of movement, locomotor time 20.30.31.30.4-0.10.20.7-0.5-0.4-0.50.5-0.6-0.4-0.6-0.60.4-1.10.1-1.2
Total resting periods, locomotor time 20.40.41.30.6-0.10.40.7-0.6-0.5-0.60.5-0.7-0.5-0.6-0.60.4-1.10.3-1.2
Rest time, locomotor task time 21.01.11.91.3-1.21.01.0-1.3-0.9-1.40.9-1.2-0.6-1.2-1.20.70.21.20.7
Distance moved, locomotor task time 22.52.95.1-2.01.4-1.7-2.22.31.82.1-1.82.01.22.12.1-1.40.4-1.2-0.3
Vertical activity count, locomotor time 23.53.86.5-2.41.3-2.3-2.52.52.12.3-1.92.21.72.22.2-1.70.7-1.20.5
Light reinforcement 10.20.31.2-0.60.7-0.6-0.50.30.50.2-0.60.30.60.40.4-0.51.1-0.10.3
Light reinforcement 21.21.63.3-1.50.2-1.8-1.41.11.60.7-1.40.81.61.11.0-1.51.4-0.01.1
Bone: marrow area0.30.76.40.02.50.70.00.1-0.60.60.40.4-0.70.40.40.9-0.3-1.2-0.2
Bone: maximum diameter0.10.20.70.00.8-0.10.1-0.10.3-0.3-0.4-0.50.4-0.5-0.5-0.4-0.00.7-0.1
Bone: maximum force0.10.10.5-0.30.7-0.2-0.50.30.10.4-0.10.40.10.40.4-0.0-0.4-0.6-0.1
Bone: maximum moment0.20.30.6-0.60.8-0.5-0.70.60.40.7-0.40.60.30.60.6-0.2-0.2-0.80.1
Mean time between licks in bursts0.91.24.00.9-1.01.00.8-0.7-1.20.01.40.1-1.40.10.11.3-1.8-1.0-2.0
Mean num. licks in bursts0.60.72.3-0.91.2-0.5-0.70.90.31.1-0.31.10.21.21.2-0.1-0.1-1.50.2
Cd content in liver0.30.41.9-0.01.40.40.3-0.2-0.5-0.10.60.2-0.50.20.20.70.7-1.10.8
Co content in liver1.51.85.8-0.72.20.0-0.70.9-0.11.80.21.8-0.61.61.60.6-1.3-2.4-1.4
Cu content in liver0.70.82.3-0.50.6-0.0-0.71.1-0.01.50.21.5-0.51.51.50.50.0-1.2-0.1
Fe content in liver1.31.66.1-1.22.5-1.0-0.90.91.10.7-1.20.51.30.40.4-1.11.9-0.12.0
K content in liver0.40.41.20.7-1.10.70.5-0.4-0.7-0.10.9-0.3-0.9-0.0-0.00.8-0.40.2-0.6
Mg content in liver0.90.94.30.9-2.10.60.6-0.7-0.2-1.10.1-1.2-0.2-0.9-0.9-0.00.32.00.0
Mn content in liver0.20.21.1-0.1-1.0-0.1-0.20.40.10.50.10.5-0.20.60.60.1-0.5-0.3-0.8
Na content in liver0.30.31.30.20.30.40.20.1-0.50.70.50.3-0.70.40.40.6-0.9-0.8-1.1
Rb content in liver0.10.20.60.4-0.80.20.4-0.4-0.3-0.40.4-0.4-0.2-0.5-0.50.2-0.20.7-0.2
Se content in liver0.10.10.8-0.30.9-0.00.00.1-0.00.20.10.1-0.10.40.40.20.2-0.70.4
Sr content in liver0.40.41.1-0.61.0-0.2-0.30.50.20.7-0.30.70.10.80.8-0.00.6-1.00.6
Zn content in liver0.40.51.20.9-0.21.10.9-0.9-0.8-0.70.6-0.6-0.9-0.4-0.40.7-0.30.3-0.4
Bone: minimum diameter0.51.02.2-1.21.5-0.8-1.11.10.61.0-0.51.00.51.21.2-0.30.7-1.20.9
Time in familiar zone, hab. session 10.90.92.4-0.80.8-0.4-0.91.20.61.4-0.51.50.01.51.4-0.2-0.1-0.9-0.2
Time in novel zone, hab. session 10.40.41.60.31.30.60.3-0.3-0.9-0.00.9-0.1-0.7-0.1-0.10.90.2-1.10.2
Total zone transitions, hab. session 10.00.00.1-0.10.3-0.3-0.0-0.2-0.1-0.30.2-0.20.2-0.2-0.20.1-0.0-0.30.2
Total locomotion distance, hab. session 10.30.40.9-0.70.5-0.9-0.80.50.80.1-0.70.10.90.30.3-0.80.60.20.6
Locomotion velocity, hab. session 10.20.31.20.1-0.7-0.40.1-0.50.2-0.9-0.2-0.80.6-0.7-0.7-0.50.31.10.4
Time in familiar zone, hab. session 20.80.82.4-0.70.3-0.3-0.81.10.31.4-0.21.5-0.21.51.50.2-0.6-1.1-0.6
Time in novel zone, hab. session 20.20.20.40.40.60.40.3-0.5-0.5-0.40.4-0.4-0.2-0.5-0.50.30.3-0.10.3
Total zone transitions, hab. session 20.20.20.9-0.50.1-0.7-0.30.30.30.6-0.20.50.40.30.3-0.2-1.0-0.8-0.6
Total locomotion distance, hab. session 20.50.61.8-1.0-0.3-1.3-0.90.71.10.5-1.00.41.20.50.5-1.10.20.20.3
Locomotion velocity, hab. session 20.60.82.3-1.0-0.3-1.5-1.00.71.20.4-1.20.31.40.40.4-1.30.40.40.5
Novel to familiar place preference ratio0.40.42.7-0.2-0.6-0.3-0.30.20.5-0.1-0.50.10.6-0.1-0.1-0.51.60.71.4
Novelty place preference0.40.42.5-0.0-0.7-0.2-0.10.00.3-0.3-0.3-0.00.4-0.2-0.2-0.31.60.61.3
Time in novel zone, NPP test0.30.32.2-0.0-0.5-0.1-0.10.00.2-0.2-0.20.00.3-0.1-0.1-0.21.50.31.3
Total zone transitions, NPP test0.81.12.3-1.41.3-1.5-1.11.11.11.0-1.10.91.20.80.8-1.00.2-0.70.5
Total locomotion distance, NPP test1.01.42.9-1.50.7-1.7-1.31.31.51.0-1.50.91.50.80.8-1.40.80.00.9
Locomotion velocity, NPP test1.41.94.0-1.70.6-2.0-1.61.51.91.1-1.80.91.90.90.9-1.80.90.20.9
Intraocular pressure0.30.51.80.6-0.50.40.7-0.6-0.1-1.1-0.0-0.90.1-1.0-1.0-0.1-0.01.40.5
Delta distance traveled before/after self-admin0.60.71.9-0.6-0.4-1.0-0.60.41.1-0.1-1.4-0.11.20.00.0-1.40.21.20.7
Delta ambulatory time before/after self-admin0.60.63.1-0.2-1.8-0.8-0.30.10.9-0.5-0.9-0.40.9-0.3-0.3-1.1-0.31.4-0.1
Parametrial fat weight0.10.30.60.40.80.60.6-0.7-0.6-0.50.6-0.6-0.5-0.4-0.40.6-0.3-0.4-0.1
Pavlov. Cond. lever latency1.31.63.21.5-1.31.71.3-1.1-1.6-0.71.6-0.6-1.8-0.4-0.41.7-1.4-0.4-1.2
Pavlov. Cond. magazine entry latency0.40.50.90.70.70.90.6-0.6-0.9-0.40.9-0.2-0.9-0.4-0.40.8-0.7-0.5-0.9
Pavlov. Cond. change in total contacts0.10.10.3-0.00.6-0.00.0-0.20.1-0.3-0.2-0.30.2-0.2-0.2-0.20.00.1-0.2
Pavlov. Cond. index score0.20.31.0-0.61.0-0.6-0.60.50.50.3-0.60.40.70.20.2-0.70.6-0.20.3
Pavlov. Cond. latency score0.20.30.6-0.60.8-0.7-0.50.40.60.1-0.60.20.80.00.0-0.70.7-0.00.4
Pavlov. Cond. lever contacts0.91.12.3-1.21.0-1.4-1.00.91.20.4-1.30.51.50.20.2-1.41.40.31.2
Pavlov. Cond. magazine entry number0.20.20.5-0.5-0.7-0.6-0.40.50.60.4-0.60.30.50.40.5-0.50.40.30.6
Pavlov. Cond. intertrial magazine entries0.80.94.60.3-1.7-0.20.1-0.50.4-0.7-0.6-0.90.7-0.8-0.8-0.71.12.21.3
Pavlov. Cond. lever-magazine prob. diff.0.30.31.0-0.61.0-0.6-0.70.60.60.3-0.60.40.70.20.2-0.70.6-0.10.4
Pavlov. Cond. response bias0.30.32.7-0.61.6-0.4-0.50.40.30.3-0.20.40.40.30.3-0.30.5-0.60.4
Pavlov. Cond. lever latency0.30.41.4-0.80.6-0.8-0.40.40.40.3-0.30.40.60.30.3-0.31.0-1.20.8
Pavlov. Cond. magazine entry latency1.11.34.91.1-0.11.60.8-0.5-1.20.11.10.0-1.70.10.11.3-2.2-0.3-2.0
Pavlov. Cond. change in total contacts0.40.61.91.0-0.41.10.6-0.6-0.5-0.40.2-0.6-0.8-0.5-0.50.4-1.41.0-1.0
Pavlov. Cond. index score0.60.83.11.1-0.21.30.7-0.6-0.9-0.10.8-0.2-1.3-0.1-0.10.9-1.80.5-1.4
Pavlov. Cond. latency score0.50.73.10.9-0.11.20.6-0.4-0.7-0.00.6-0.1-1.1-0.1-0.10.7-1.80.5-1.4
Pavlov. Cond. lever contacts0.20.20.90.70.10.80.3-0.3-0.4-0.20.2-0.2-0.6-0.2-0.20.3-0.81.0-0.4
Pavlov. Cond. magazine entry number1.31.65.3-1.40.3-1.7-1.21.01.40.5-1.30.51.70.50.5-1.32.30.02.1
Pavlov. Cond. intertrial magazine entries0.10.21.00.3-1.00.10.5-0.4-0.2-0.50.3-0.5-0.0-0.5-0.50.10.20.20.2
Pavlov. Cond. lever-magazine prob. diff.0.71.03.41.2-0.21.50.8-0.6-1.0-0.10.9-0.2-1.4-0.1-0.11.0-1.80.5-1.5
Pavlov. Cond. response bias0.60.82.51.2-0.51.30.8-0.7-0.9-0.40.8-0.5-1.2-0.4-0.40.9-1.60.7-1.2
Time in closed arm before self-admin1.31.52.31.4-1.11.31.4-1.4-1.0-1.30.8-1.1-1.0-1.1-1.10.7-1.51.3-1.5
Time in closed arm after self-admin0.20.20.80.1-0.40.2-0.1-0.0-0.30.30.40.2-0.40.50.50.4-0.9-0.4-0.6
Time in open arm before self-admin0.70.81.7-0.91.0-0.6-1.01.00.41.0-0.21.00.31.01.0-0.10.9-1.31.1
Time in open arm after self-admin0.10.10.40.10.60.10.4-0.1-0.0-0.40.0-0.30.1-0.6-0.60.00.50.10.2
Bone: periosteal estimation0.30.64.2-0.82.1-0.5-0.80.80.60.8-0.70.60.50.60.6-0.40.3-0.70.4
Bone: periosteal perimeter0.10.21.5-0.31.2-0.1-0.30.20.20.3-0.40.10.20.10.1-0.20.4-0.10.4
Bone: post-yield work0.20.31.50.41.20.70.3-0.5-0.6-0.30.4-0.5-0.6-0.2-0.20.6-0.8-0.2-0.6
Progressive ratio test 1 active lever presses0.10.10.2-0.10.4-0.2-0.1-0.00.30.1-0.4-0.20.3-0.1-0.1-0.4-0.10.5-0.5
Progressive ratio test 1 breakpoint0.10.10.3-0.30.5-0.4-0.30.10.40.1-0.6-0.10.50.10.1-0.6-0.00.4-0.2
Progressive ratio test 1 inactive lever presses0.70.82.6-1.11.6-0.9-1.00.80.90.6-1.00.50.90.80.8-0.80.7-0.30.6
Progressive ratio test 2 active lever presses0.40.51.4-0.6-0.0-0.6-0.70.41.00.2-1.2-0.10.80.50.5-1.10.70.90.1
Progressive ratio test 2 breakpoint0.20.30.8-0.4-0.2-0.4-0.40.20.70.0-0.9-0.20.60.30.3-0.80.50.9-0.1
Progressive ratio test 2 inactive lever presses0.70.81.8-0.70.1-0.9-0.80.51.20.1-1.3-0.11.20.40.3-1.31.01.30.9
Incentive Sensitization - Responses0.91.03.81.0-1.20.80.9-1.2-0.3-1.2-0.0-1.3-0.2-1.1-1.2-0.10.12.0-0.4
Incentive Sensitization - Breakpoint0.70.73.00.8-1.10.70.7-0.9-0.2-0.9-0.1-1.1-0.2-0.9-0.9-0.10.11.7-0.4
Sum of active levers in priming session hrs 5-61.31.34.9-1.22.2-0.7-1.21.30.61.4-0.41.30.31.21.2-0.20.0-1.7-0.2
Progressive ratio0.60.73.10.3-1.7-0.30.2-0.40.4-0.8-0.5-0.80.7-0.9-0.9-0.80.61.70.1
Food seeking constrained by brief footshock1.51.94.51.2-0.11.71.1-0.9-1.9-0.32.0-0.3-2.0-0.3-0.32.1-1.8-1.4-1.3
Seeking ratio, punishment vs. effort1.72.06.90.51.51.40.4-0.1-1.60.71.80.7-2.00.90.92.1-1.8-2.6-1.1
Retroperitoneal fat weight0.31.11.81.3-1.31.11.3-1.3-1.0-1.01.0-1.1-1.0-1.0-1.00.9-0.90.7-0.7
Reaction time number correct0.00.10.30.20.30.40.2-0.1-0.20.20.10.0-0.2-0.2-0.20.20.1-0.4-0.5
Reaction time mean minus median0.81.01.81.2-1.11.11.0-1.3-0.8-1.30.8-1.4-0.7-1.2-1.10.6-0.80.7-0.7
Reaction time mean minus median AUC0.20.30.60.70.10.80.5-0.7-0.6-0.70.5-0.6-0.5-0.6-0.50.5-0.4-0.0-0.3
Reaction time num false alarms0.50.71.7-0.80.2-1.1-0.90.61.10.6-1.30.21.30.30.3-1.30.51.10.5
Reaction time num false alarms AUC0.91.22.7-1.20.6-1.4-1.10.91.40.9-1.60.61.60.50.5-1.60.70.90.7
Reaction time trials correct on left0.00.10.30.20.30.40.2-0.1-0.20.20.10.0-0.2-0.2-0.20.20.1-0.4-0.5
Reaction time trials on left0.00.10.30.30.20.40.2-0.1-0.20.10.1-0.1-0.2-0.3-0.30.20.1-0.3-0.5
Reaction time mean1.82.54.61.8-1.81.31.8-2.0-1.3-2.11.2-2.1-0.8-2.1-2.10.7-0.61.6-0.2
Reaction time mean AUC1.41.93.11.6-1.41.31.6-1.8-1.3-1.71.3-1.6-0.9-1.8-1.70.9-0.71.0-0.4
Median of all reaction times2.23.05.42.0-1.81.42.0-2.2-1.4-2.31.3-2.2-0.9-2.3-2.30.8-0.51.8-0.2
Reaction time omissions1.01.33.81.1-0.40.71.5-1.5-0.7-1.50.5-1.8-0.1-1.9-1.90.2-0.11.10.0
Reaction time false alarm rate1.11.52.8-1.40.5-1.7-1.41.11.61.0-1.60.71.70.80.8-1.60.80.91.1
Reaction time premature initiation rate0.10.10.40.30.10.60.2-0.1-0.40.20.40.2-0.60.20.20.6-0.2-0.30.1
Reaction time premature initiations0.20.30.90.60.11.00.5-0.3-0.70.20.60.1-0.9-0.0-0.00.9-0.3-0.5-0.5
Std. dev. reaction times0.60.81.31.0-1.20.81.0-1.1-0.7-1.00.7-1.1-0.6-1.1-1.00.5-0.90.5-0.7
Reaction time trials completed0.00.10.30.30.20.40.2-0.1-0.20.10.1-0.1-0.2-0.3-0.30.20.1-0.3-0.5
Reaction time trials AUC0.00.00.10.10.30.20.10.0-0.10.3-0.10.1-0.1-0.2-0.20.10.2-0.3-0.4
Run reversals in cocaine runway, females2.52.44.41.7-1.91.11.9-2.0-1.1-2.11.1-2.0-0.7-1.9-1.90.7-0.91.90.0
Run reversals in cocaine runway, males2.12.03.6-1.61.2-1.6-1.91.81.51.5-1.61.51.41.31.3-1.41.3-0.21.0
Latency to leave start box in cocaine runway0.30.30.9-0.60.9-0.6-0.50.50.70.4-0.90.40.80.10.1-0.90.60.20.1
Latency to leave start box in cocaine runway, F1.01.14.0-1.02.0-0.9-1.00.91.20.6-1.50.61.30.30.3-1.31.20.20.9
Latency to leave start box in cocaine runway, M0.10.10.40.1-0.6-0.00.1-0.2-0.20.00.40.0-0.20.10.10.3-0.3-0.2-0.2
Std. dev. time between licks in bursts2.22.66.21.7-2.51.61.6-1.5-1.6-1.11.8-0.9-1.8-0.8-0.81.6-2.40.1-2.2
Total sessions with >9 infusions0.91.01.71.2-1.31.01.2-1.1-0.8-0.90.8-1.0-0.9-0.9-0.90.6-0.71.0-1.2
Short access day 1 total inactive lever presses3.53.98.1-2.00.7-2.3-2.21.82.41.0-2.51.02.51.21.2-2.52.91.32.4
Short access day 10 total inactive lever presses2.93.26.0-2.12.3-2.1-1.91.71.81.2-1.71.22.01.21.2-1.62.3-0.72.5
Short access day 1 total infusions0.50.52.30.30.00.00.4-0.60.1-0.7-0.2-0.90.5-0.9-0.9-0.40.91.50.9
Short access day 10 total infusions0.20.20.5-0.30.0-0.5-0.40.30.60.5-0.70.20.50.20.2-0.7-0.20.5-0.7
Short access total infusions0.10.10.7-0.10.1-0.30.1-0.20.3-0.2-0.4-0.40.5-0.3-0.3-0.50.40.90.3
Short access day 1 locomotion0.30.31.2-0.3-0.2-0.6-0.50.30.70.1-0.70.00.70.20.1-0.80.61.10.5
Short access day 10 total locomotion0.40.51.1-0.60.9-0.8-0.60.50.90.3-1.10.11.00.00.0-1.00.50.90.4
Short access total locomotion0.10.10.3-0.10.2-0.1-0.20.30.10.6-0.10.4-0.10.40.4-0.0-0.20.1-0.5
One hour access (0.3 mA shock)0.50.61.00.9-1.01.00.8-0.8-0.7-0.70.7-0.9-0.8-0.5-0.60.7-0.80.7-0.9
Compulsive drug intake0.40.43.40.21.80.60.3-0.5-0.6-0.70.5-0.4-0.4-0.2-0.10.6-0.1-0.80.2
One hour access (shock baseline)0.20.32.0-0.0-1.4-0.1-0.30.40.40.7-0.40.40.10.40.3-0.3-0.10.8-0.5
Social response proportion0.91.05.01.2-2.21.10.9-1.0-1.0-0.61.0-0.6-1.1-0.5-0.50.9-0.90.4-1.0
Social responses0.50.61.40.9-0.81.10.6-0.5-0.90.20.80.1-1.1-0.1-0.11.0-1.2-0.2-1.2
Social time0.60.81.5-1.10.8-1.0-1.01.00.91.2-0.91.10.90.80.7-0.70.7-0.70.4
Soleus weight2.67.812.7-3.12.6-2.6-3.63.53.33.0-3.42.82.52.82.8-2.81.8-0.41.8
Bone: stiffness0.20.30.90.5-0.40.40.7-0.8-0.3-0.90.3-0.9-0.1-0.9-0.90.2-0.10.50.0
Tibialis anterior weight2.48.114.3-3.52.1-3.7-3.23.03.82.0-3.81.73.71.92.0-3.72.20.12.4
Time to tail flick, vehicle, before self-admin0.50.61.5-0.30.9-0.60.2-0.40.5-1.2-0.6-0.90.9-0.7-0.7-0.70.80.80.9
Time to tail flick, vehicle, after self-admin0.60.71.7-0.80.9-1.0-0.80.61.10.1-1.10.51.20.10.1-1.30.60.70.8
Time to tail flick, test, before self-admin0.60.61.2-0.70.9-0.6-1.10.70.90.2-1.00.30.80.80.8-0.90.70.40.9
Time to tail flick, test, after self-admin1.61.62.6-1.50.6-1.5-1.51.31.50.9-1.41.21.51.01.0-1.51.6-0.31.3
Delta time to tail flick, vehicle, before/after SA1.11.12.5-1.00.2-1.0-1.41.41.11.5-1.01.60.81.11.1-1.00.5-0.30.3
Delta time to tail flick, test, before/after SA0.10.00.2-0.1-0.4-0.30.2-0.10.00.00.10.20.2-0.3-0.3-0.10.4-0.00.1
Tibia length0.10.31.20.40.20.20.5-0.6-0.1-0.6-0.1-0.70.2-1.0-1.0-0.10.11.10.2
Ambulatory time before self-admin4.14.27.3-2.52.2-2.0-2.22.51.72.6-1.42.71.32.52.5-1.11.4-2.11.2
Ambulatory time after self-admin2.62.85.0-2.20.7-2.2-1.92.02.01.6-1.81.71.71.81.8-1.70.8-0.70.9
Bone: tissue strength0.80.72.50.2-0.20.7-0.10.3-0.50.70.50.8-1.11.01.00.9-1.6-1.0-1.3
Total heroin consumption1.82.14.01.7-0.71.71.5-1.7-1.6-1.41.5-1.4-1.5-1.2-1.21.4-1.20.2-2.0
Bone: trabecular number0.60.95.2-0.20.80.20.10.3-0.80.91.10.9-0.90.80.81.1-1.0-2.3-1.1
Bone: trabecular spacing0.71.03.6-0.4-0.4-0.8-0.50.31.2-0.3-1.5-0.31.4-0.4-0.4-1.60.81.91.1
Bone: trabecular thickness0.60.83.6-0.20.60.10.00.2-0.50.70.70.8-0.70.70.70.8-1.6-1.9-1.4
Bone: trabecular tissue density0.10.20.70.0-0.20.0-0.30.30.4-0.0-0.50.10.10.30.3-0.3-0.80.8-0.8
Water consumed over 24 hours1.92.34.7-1.72.1-1.3-1.41.70.92.2-0.72.10.61.81.8-0.40.4-2.00.6
Number of responses in last shaping day1.31.32.5-1.31.1-1.6-1.01.21.31.1-1.21.31.40.80.8-1.30.8-0.21.1