Aco2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Aco2 0.04 0.03 9.7e-04 0.05 0.04 0.04 0.04 6.6e-05 4.8e-04 1.8e-04 3.3e-04
2 Brain gene expression Aco2 0.08 0.06 7.8e-06 0.04 0.06 0.05 0.05 5.1e-05 7.3e-06 1.2e-05 1.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.90.61.0
Area under the delay curve0.10.10.20.50.2
BMI with tail0.72.33.7-1.9-0.9
BMI without tail0.00.00.00.10.0
Body weight1.25.47.2-2.7-1.9
Weight adjusted by age0.30.50.80.4-0.9
Bone surface0.10.20.40.60.1
Bone volume0.00.00.10.30.2
Breakpoint value in progressive ratio session0.10.20.3-0.10.6
Number of licking bursts0.30.50.80.90.4
Context. condit. distance diff. score6.98.38.3-2.9-2.9
Locomotion velocity, session 10.60.61.10.3-1.0
Locomotion distance, session 11.51.93.61.90.5
Locomotion velocity, session 20.20.20.4-0.3-0.6
Locomotion distance, session 22.83.94.02.02.0
Locomotion velocity, session 30.60.71.3-0.4-1.1
Locomotion distance, session 30.40.50.91.0-0.2
Stereotopy head waving bouts, day 30.50.60.7-0.8-0.8
Stereotopy head waving duration, day 32.73.23.4-1.8-1.8
Locomotion velocity, session 70.60.60.9-0.6-0.9
Locomotion distance, session 70.00.00.1-0.30.2
Stereotopy head waving bouts, day 73.74.26.4-1.4-2.5
Stereotopy head waving duration, day 72.63.14.4-1.4-2.1
Locomotion velocity, session 81.62.02.0-1.4-1.4
Locomotion distance, session 80.71.01.3-0.9-1.2
Degree of sensitization distance1.61.63.2-1.8-0.1
Degree of sensitization stereotypy3.03.24.9-1.2-2.2
Conditioned locomotion0.91.11.5-0.8-1.2
Cocaine response after cond. corrected0.20.20.3-0.4-0.5
Cocaine response after cond. not corrected0.00.10.1-0.1-0.3
Cocaine response before conditioning0.40.50.60.80.6
Saline control response0.10.10.10.2-0.3
Bone: connectivity density0.10.10.20.20.5
Bone: cortical apparent density0.81.11.51.20.8
Bone: cortical area1.01.61.7-1.3-1.2
Bone: cortical porosity0.20.20.4-0.6-0.2
Bone: cortical porosity1.31.41.8-1.3-1.0
Bone: cortical thickness0.10.20.3-0.50.2
Bone: cortical thickness0.10.10.2-0.40.1
Bone: cortical tissue density0.70.91.31.10.8
Condit. Reinf. active minus inactive responses0.30.30.30.50.6
Condit. Reinf. active-inactive response ratio0.20.20.3-0.3-0.6
Condit. Reinf. active responses2.32.82.81.71.7
Condit. Reinf. inactive responses4.25.15.32.32.2
Incentive salience index mean0.81.01.10.91.0
Condit. Reinf. lever presses1.21.71.81.31.3
Condit. Reinf. active minus inactive responses0.10.10.2-0.00.4
Condit. Reinf. active-inactive response ratio0.10.10.2-0.40.3
Condit. Reinf. active responses0.20.30.3-0.6-0.6
Condit. Reinf. inactive responses0.81.11.6-0.8-1.3
Condit. Reinf. lever presses0.50.81.00.71.0
Condit. Reinf. lever reinforcers received0.10.10.1-0.4-0.2
Conditioned reinforcement - actives0.40.60.8-0.7-0.9
Conditioned reinforcement - inactives0.30.50.90.21.0
Conditioned locomotion1.01.31.9-1.4-0.8
Patch foraging indifference point 0 sec0.81.52.01.01.4
Patch foraging indifference point AUC0.10.20.30.5-0.1
Delay disc. indifference point, 0s delay0.40.40.7-0.8-0.4
Delay disc. indifference point, 16s delay0.60.60.60.80.8
Delay disc. indifference point, 2s delay0.00.00.10.1-0.2
Delay disc. indifference point, 24s delay0.40.40.80.0-0.9
Delay disc. indifference point, 4s delay0.20.20.30.40.5
Delay disc. indifference point, 8s delay0.40.50.60.80.6
Indifference point function ln k0.61.01.5-1.2-0.7
Indifference point function log k0.61.01.5-1.2-0.7
Patch foraging total patch changes 0 sec1.01.82.31.21.5
Patch foraging total patch changes 12 sec0.10.10.10.20.3
Patch foraging total patch changes 18 sec0.30.50.70.60.8
Patch foraging total patch changes 24 sec0.30.50.70.90.5
Patch foraging total patch changes 6 sec0.61.01.01.01.0
Patch foraging time to switch 0 sec0.00.00.00.00.2
Patch foraging water rate 0 sec0.30.60.80.60.9
Patch foraging water rate 12 sec0.40.71.01.00.7
Patch foraging water rate 18 sec1.01.61.91.41.1
Patch foraging water rate 24 sec0.00.10.1-0.10.3
Patch foraging water rate 6 sec0.50.81.21.10.5
Seeking ratio, delayed vs. immediate footshock3.03.63.81.81.9
Distance traveled before self-admin0.81.11.90.51.4
Distance traveled after self-admin0.50.60.80.60.9
Extensor digitorum longus weight0.20.70.80.90.8
Bone: elastic displacement0.30.30.6-0.2-0.8
Bone: elastic work1.82.42.9-1.7-1.3
Bone: endosteal estimation0.71.62.6-0.8-1.6
Bone: endosteal perimeter2.14.66.4-1.7-2.5
Epididymis fat weight2.27.510.1-3.2-2.2
Delta time in closed arm before/after self-admin0.20.20.2-0.5-0.3
Delta time in open arm before/after self-admin0.40.40.70.8-0.3
Diff in mean of infusions in LGA sessions0.20.20.3-0.5-0.3
Delay discount exponential model param0.20.20.3-0.6-0.1
Extinction: sum of active levers before priming0.80.91.3-1.2-0.6
Active lever presses in extinction session 60.00.00.1-0.3-0.1
Bone: final force0.91.52.4-1.6-0.8
Bone: final moment1.01.72.6-1.6-0.8
Food consumed during 24 hour testing period1.11.62.3-1.5-0.9
Glucose0.30.50.70.50.9
Heart weight4.26.58.0-2.8-2.2
Delay discount hyperbolic model param0.10.20.3-0.5-0.1
Intermittent access intake day 1-15 change0.20.40.60.40.8
Intermittent access intake escalation0.20.50.50.60.7
Intermittent access intake escalation 20.40.50.60.60.8
Intermitt. access day 1 inactive lever presses0.10.40.8-0.30.9
Intermitt. access day 15 inactive lever presses0.61.12.30.01.5
Intermitt. access escalation Index0.30.50.60.80.6
Intermittent access day 1 total infusions0.10.20.3-0.6-0.4
Intermittent access day 15 total infusions0.10.10.20.40.3
Intermittent access terminal intake (last 3 days)0.00.00.00.0-0.1
Intermittent access total infusions0.10.10.2-0.4-0.3
Intermittent access day 1 locomotion0.10.20.3-0.10.6
Intermittent access day 15 total locomotion0.10.20.3-0.6-0.0
Intermittent access total locomotion0.20.30.5-0.70.0
Intermittent access standard deviation0.20.40.6-0.80.3
Left kidney weight9.142.451.4-7.2-5.8
Right kidney weight10.146.262.0-7.9-5.5
Cocaine induced anxiety1.11.62.9-1.7-0.6
Post-drug Anxiety0.10.10.2-0.4-0.2
Baseline Anxiety1.61.93.51.90.6
Tail length0.31.32.41.50.4
Length with tail0.31.51.8-1.1-1.3
Length without tail2.16.79.7-3.1-1.9
Times rat made contact with spout0.50.50.7-0.9-0.6
Lifetime Intake0.30.40.7-0.8-0.3
Liver weight, left2.03.35.1-1.2-2.3
Liver weight, right2.95.16.5-1.9-2.6
Locomotor activity2.43.74.3-2.1-1.8
Locomotor testing distance0.00.00.00.10.2
Locomotor testing rearing1.12.32.4-1.6-1.5
Locomotion in novel chamber0.50.71.31.1-0.3
Locomotion in novel chamber post-restriction0.30.50.80.90.5
Fecal boli incidents, locomotor time 10.10.10.10.20.4
Change in fecal boli incidents, locomotor task2.12.03.3-0.9-1.8
Time >=10cm from walls, locomotor time 10.20.20.4-0.6-0.3
Bouts of movement, locomotor time 10.91.11.4-1.2-0.8
Total resting periods, locomotor time 10.50.61.1-1.0-0.3
Rest time, locomotor task time 10.60.81.6-1.3-0.1
Distance moved, locomotor task time 10.20.30.50.0-0.7
Vertical activity count, locomotor time 10.00.10.10.30.1
Time >=10cm from walls, locomotor time 20.00.00.10.30.0
Bouts of movement, locomotor time 20.20.30.6-0.80.1
Total resting periods, locomotor time 20.20.30.6-0.70.2
Rest time, locomotor task time 20.00.10.1-0.20.2
Distance moved, locomotor task time 20.30.40.8-0.3-0.9
Vertical activity count, locomotor time 20.10.10.2-0.2-0.4
Light reinforcement 10.10.40.50.4-0.7
Light reinforcement 20.60.91.0-1.0-1.0
Bone: marrow area0.81.72.7-0.9-1.6
Bone: maximum diameter3.26.06.1-2.5-2.4
Bone: maximum force1.42.63.8-2.0-1.1
Bone: maximum moment1.73.04.3-2.1-1.3
Mean time between licks in bursts0.30.70.80.90.8
Mean num. licks in bursts1.52.32.9-1.7-1.3
Cd content in liver1.71.92.5-1.1-1.6
Co content in liver0.00.10.1-0.10.3
Cu content in liver6.88.19.83.12.5
Fe content in liver0.30.30.5-0.7-0.3
K content in liver1.41.31.41.21.1
Mg content in liver1.71.72.01.21.4
Mn content in liver0.10.10.20.1-0.5
Na content in liver2.52.63.11.81.5
Rb content in liver0.00.00.1-0.3-0.0
Se content in liver0.20.30.50.70.2
Sr content in liver2.82.42.81.71.4
Zn content in liver0.10.10.10.3-0.3
Bone: minimum diameter0.50.91.4-0.6-1.2
Time in familiar zone, hab. session 10.50.50.9-0.3-1.0
Time in novel zone, hab. session 10.10.10.2-0.5-0.1
Total zone transitions, hab. session 12.23.05.02.21.0
Total locomotion distance, hab. session 11.01.52.91.70.1
Locomotion velocity, hab. session 11.42.03.82.00.5
Time in familiar zone, hab. session 20.30.40.70.0-0.8
Time in novel zone, hab. session 20.10.20.30.00.5
Total zone transitions, hab. session 21.11.42.01.40.9
Total locomotion distance, hab. session 21.01.31.71.30.9
Locomotion velocity, hab. session 21.62.22.91.71.2
Novel to familiar place preference ratio2.93.13.3-1.7-1.8
Novelty place preference4.14.55.0-2.0-2.2
Time in novel zone, NPP test5.15.56.0-2.2-2.4
Total zone transitions, NPP test2.23.25.32.31.0
Total locomotion distance, NPP test1.11.62.31.50.9
Locomotion velocity, NPP test1.82.53.81.91.1
Intraocular pressure0.50.81.1-0.7-1.1
Delta distance traveled before/after self-admin0.91.01.8-0.4-1.3
Delta ambulatory time before/after self-admin1.01.22.1-0.5-1.5
Parametrial fat weight0.10.20.4-0.1-0.7
Pavlov. Cond. lever latency0.91.11.3-0.9-1.1
Pavlov. Cond. magazine entry latency0.70.91.30.71.1
Pavlov. Cond. change in total contacts1.81.92.41.21.5
Pavlov. Cond. index score0.60.81.30.51.1
Pavlov. Cond. latency score0.60.81.30.51.1
Pavlov. Cond. lever contacts2.32.73.11.51.8
Pavlov. Cond. magazine entry number0.70.91.4-0.6-1.2
Pavlov. Cond. intertrial magazine entries1.21.41.41.21.2
Pavlov. Cond. lever-magazine prob. diff.0.70.81.30.61.1
Pavlov. Cond. response bias1.11.42.00.91.4
Pavlov. Cond. lever latency1.62.23.1-1.1-1.8
Pavlov. Cond. magazine entry latency4.65.58.11.72.8
Pavlov. Cond. change in total contacts1.32.13.80.52.0
Pavlov. Cond. index score3.04.16.11.42.5
Pavlov. Cond. latency score3.85.17.41.72.7
Pavlov. Cond. lever contacts1.92.63.61.31.9
Pavlov. Cond. magazine entry number2.63.24.9-1.2-2.2
Pavlov. Cond. intertrial magazine entries1.42.02.7-1.6-1.2
Pavlov. Cond. lever-magazine prob. diff.3.24.36.31.52.5
Pavlov. Cond. response bias2.02.73.91.22.0
Time in closed arm before self-admin5.77.38.52.92.5
Time in closed arm after self-admin0.00.00.00.2-0.0
Time in open arm before self-admin0.20.20.3-0.4-0.5
Time in open arm after self-admin0.10.20.20.3-0.5
Bone: periosteal estimation1.22.53.2-1.3-1.8
Bone: periosteal perimeter4.17.08.4-2.4-2.9
Bone: post-yield work0.10.20.4-0.6-0.2
Progressive ratio test 1 active lever presses0.00.00.1-0.30.0
Progressive ratio test 1 breakpoint0.00.00.0-0.2-0.0
Progressive ratio test 1 inactive lever presses0.50.71.3-0.21.1
Progressive ratio test 2 active lever presses0.00.00.0-0.20.1
Progressive ratio test 2 breakpoint0.00.00.0-0.20.0
Progressive ratio test 2 inactive lever presses0.81.41.81.01.3
Incentive Sensitization - Responses0.00.10.10.20.3
Incentive Sensitization - Breakpoint0.00.00.00.10.2
Sum of active levers in priming session hrs 5-60.00.00.0-0.2-0.1
Progressive ratio0.30.40.80.10.9
Food seeking constrained by brief footshock1.41.71.8-1.3-1.2
Seeking ratio, punishment vs. effort0.71.01.3-0.8-1.1
Retroperitoneal fat weight4.218.122.5-4.7-3.7
Reaction time number correct0.30.61.21.1-0.1
Reaction time mean minus median0.00.10.1-0.1-0.3
Reaction time mean minus median AUC0.30.70.9-0.9-0.8
Reaction time num false alarms0.20.20.30.5-0.4
Reaction time num false alarms AUC0.20.30.60.7-0.4
Reaction time trials correct on left0.30.61.21.1-0.1
Reaction time trials on left0.40.71.41.2-0.1
Reaction time mean0.20.40.40.60.6
Reaction time mean AUC0.20.30.30.50.5
Median of all reaction times0.50.70.70.80.9
Reaction time omissions0.30.40.80.9-0.1
Reaction time false alarm rate0.00.00.00.1-0.2
Reaction time premature initiation rate0.60.81.50.31.2
Reaction time premature initiations0.30.60.90.50.9
Std. dev. reaction times0.10.10.2-0.2-0.5
Reaction time trials completed0.40.71.41.2-0.1
Reaction time trials AUC0.30.51.01.0-0.1
Run reversals in cocaine runway, females0.50.51.01.0-0.3
Run reversals in cocaine runway, males1.91.93.2-0.8-1.8
Latency to leave start box in cocaine runway0.20.20.4-0.6-0.1
Latency to leave start box in cocaine runway, F0.00.00.10.10.2
Latency to leave start box in cocaine runway, M0.80.81.4-1.2-0.4
Std. dev. time between licks in bursts1.92.62.71.61.6
Total sessions with >9 infusions2.63.15.2-2.3-1.0
Short access day 1 total inactive lever presses0.20.30.6-0.80.2
Short access day 10 total inactive lever presses0.20.60.7-0.8-0.7
Short access day 1 total infusions0.40.51.0-1.0-0.1
Short access day 10 total infusions0.50.71.2-1.1-0.3
Short access total infusions0.91.12.1-1.4-0.3
Short access day 1 locomotion0.40.50.9-1.00.3
Short access day 10 total locomotion0.50.91.70.41.3
Short access total locomotion0.30.40.7-0.90.3
One hour access (0.3 mA shock)0.20.20.20.40.5
Compulsive drug intake0.10.10.20.40.0
One hour access (shock baseline)0.10.10.20.10.4
Social response proportion0.30.30.5-0.30.7
Social responses0.10.10.10.4-0.2
Social time1.82.52.51.61.6
Soleus weight0.10.30.30.60.5
Bone: stiffness0.71.11.7-1.3-0.7
Tibialis anterior weight0.93.03.41.61.8
Time to tail flick, vehicle, before self-admin0.00.00.0-0.00.0
Time to tail flick, vehicle, after self-admin0.60.71.51.20.0
Time to tail flick, test, before self-admin1.21.21.5-1.0-1.2
Time to tail flick, test, after self-admin0.20.20.40.7-0.1
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1-0.0
Delta time to tail flick, test, before/after SA2.93.03.92.01.5
Tibia length1.02.62.7-1.6-1.6
Ambulatory time before self-admin0.60.91.30.71.1
Ambulatory time after self-admin1.21.42.01.40.9
Bone: tissue strength0.30.30.4-0.6-0.6
Total heroin consumption0.10.10.2-0.4-0.2
Bone: trabecular number0.00.10.20.0-0.4
Bone: trabecular spacing1.31.72.3-1.5-1.0
Bone: trabecular thickness0.60.70.90.71.0
Bone: trabecular tissue density3.45.06.31.92.5
Water consumed over 24 hours0.30.40.5-0.7-0.5
Number of responses in last shaping day3.13.45.71.12.4