Hub : Genes

Aco2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Aco2 0.04 0.03 9.7e-04 0.05 0.04 0.04 0.04 6.6e-05 4.8e-04 1.8e-04 3.4e-04
2 Brain gene expression Aco2 0.08 0.06 7.8e-06 0.04 0.06 0.05 0.05 5.1e-05 7.3e-06 1.2e-05 8.9e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.70.9-0.61.0
Area under the delay curve0.10.10.2-0.50.2
BMI with tail0.72.33.71.9-0.9
BMI without tail0.00.00.0-0.10.0
Body weight1.25.47.22.7-1.9
Weight adjusted by age0.20.50.8-0.4-0.9
Bone surface0.10.20.4-0.60.1
Bone volume0.00.00.1-0.30.2
Breakpoint value in progressive ratio session0.10.20.30.10.6
Number of licking bursts0.20.50.8-0.90.4
Context. condit. distance diff. score6.88.38.32.9-2.9
Locomotion velocity, session 10.50.61.1-0.3-1.0
Locomotion distance, session 11.51.93.6-1.90.5
Locomotion velocity, session 20.20.20.40.3-0.6
Locomotion distance, session 22.83.94.0-2.02.0
Locomotion velocity, session 30.60.71.30.4-1.1
Locomotion distance, session 30.40.50.9-1.0-0.2
Stereotopy head waving bouts, day 30.50.60.70.8-0.8
Stereotopy head waving duration, day 32.63.23.41.8-1.8
Locomotion velocity, session 70.60.60.90.6-0.9
Locomotion distance, session 70.00.00.10.30.2
Stereotopy head waving bouts, day 73.64.26.41.4-2.5
Stereotopy head waving duration, day 72.53.14.41.4-2.1
Locomotion velocity, session 81.62.02.01.4-1.4
Locomotion distance, session 80.71.01.30.9-1.2
Degree of sensitization distance1.51.63.21.8-0.1
Degree of sensitization stereotypy2.93.24.91.2-2.2
Conditioned locomotion0.91.11.50.8-1.2
Cocaine response after cond. corrected0.10.20.30.4-0.5
Cocaine response after cond. not corrected0.00.10.10.1-0.3
Cocaine response before conditioning0.40.50.6-0.80.6
Saline control response0.10.10.1-0.2-0.3
Bone: connectivity density0.10.10.2-0.20.5
Bone: cortical apparent density0.71.11.5-1.20.8
Bone: cortical area1.01.61.71.3-1.2
Bone: cortical porosity0.20.20.40.6-0.2
Bone: cortical porosity1.31.41.81.3-1.0
Bone: cortical thickness0.10.20.30.50.2
Bone: cortical thickness0.10.10.20.40.1
Bone: cortical tissue density0.60.91.3-1.10.8
Condit. Reinf. active minus inactive responses0.20.30.3-0.50.6
Condit. Reinf. active-inactive response ratio0.20.20.30.3-0.6
Condit. Reinf. active responses2.22.82.8-1.71.7
Condit. Reinf. inactive responses4.05.15.3-2.32.2
Incentive salience index mean0.81.01.1-0.91.0
Condit. Reinf. lever presses1.11.71.8-1.31.3
Condit. Reinf. active minus inactive responses0.10.10.20.00.4
Condit. Reinf. active-inactive response ratio0.10.10.20.40.3
Condit. Reinf. active responses0.20.30.30.6-0.6
Condit. Reinf. inactive responses0.71.11.60.8-1.3
Condit. Reinf. lever presses0.50.81.0-0.71.0
Condit. Reinf. lever reinforcers received0.10.10.10.4-0.2
Conditioned reinforcement - actives0.20.60.80.7-0.9
Conditioned reinforcement - inactives0.20.50.9-0.21.0
Conditioned locomotion0.81.31.91.4-0.8
Patch foraging indifference point 0 sec0.51.52.0-1.01.4
Patch foraging indifference point AUC0.10.20.3-0.5-0.1
Delay disc. indifference point, 0s delay0.40.40.70.8-0.4
Delay disc. indifference point, 16s delay0.40.60.6-0.80.8
Delay disc. indifference point, 2s delay0.00.00.1-0.1-0.2
Delay disc. indifference point, 24s delay0.30.40.8-0.0-0.9
Delay disc. indifference point, 4s delay0.20.20.3-0.40.5
Delay disc. indifference point, 8s delay0.30.50.6-0.80.6
Indifference point function ln k0.31.01.51.2-0.7
Indifference point function log k0.31.01.51.2-0.7
Patch foraging total patch changes 0 sec0.61.82.3-1.21.5
Patch foraging total patch changes 12 sec0.10.10.1-0.20.3
Patch foraging total patch changes 18 sec0.20.50.7-0.60.8
Patch foraging total patch changes 24 sec0.10.50.7-0.90.5
Patch foraging total patch changes 6 sec0.61.01.0-1.01.0
Patch foraging time to switch 0 sec0.00.00.0-0.00.2
Patch foraging water rate 0 sec0.10.60.8-0.60.9
Patch foraging water rate 12 sec0.20.71.0-1.00.7
Patch foraging water rate 18 sec0.71.61.9-1.41.1
Patch foraging water rate 24 sec0.00.10.10.10.3
Patch foraging water rate 6 sec0.50.81.2-1.10.5
Seeking ratio, delayed vs. immediate footshock2.53.63.8-1.81.9
Distance traveled before self-admin0.51.11.9-0.51.4
Distance traveled after self-admin0.30.60.8-0.60.9
Extensor digitorum longus weight0.20.70.8-0.90.8
Bone: elastic displacement0.20.30.60.2-0.8
Bone: elastic work1.82.42.91.7-1.3
Bone: endosteal estimation0.71.62.60.8-1.6
Bone: endosteal perimeter1.94.66.41.7-2.5
Epididymis fat weight1.57.510.13.2-2.2
Delta time in closed arm before/after self-admin0.20.20.20.5-0.3
Delta time in open arm before/after self-admin0.30.40.7-0.8-0.3
Diff in mean of infusions in LGA sessions0.10.20.30.5-0.3
Delay discount exponential model param0.10.20.30.6-0.1
Extinction: sum of active levers before priming0.60.91.31.2-0.6
Active lever presses in extinction session 60.00.00.10.3-0.1
Bone: final force0.91.52.41.6-0.8
Bone: final moment1.01.72.61.6-0.8
Food consumed during 24 hour testing period0.81.62.31.5-0.9
Glucose0.30.50.7-0.50.9
Heart weight4.06.58.02.8-2.2
Delay discount hyperbolic model param0.10.20.30.5-0.1
Intermittent access intake day 1-15 change0.10.40.6-0.40.8
Intermittent access intake escalation0.10.50.5-0.60.7
Intermittent access intake escalation 20.30.50.6-0.60.8
Intermitt. access day 1 inactive lever presses0.00.40.80.30.9
Intermitt. access day 15 inactive lever presses0.21.12.3-0.01.5
Intermitt. access escalation Index0.10.50.6-0.80.6
Intermittent access day 1 total infusions0.10.20.30.6-0.4
Intermittent access day 15 total infusions0.10.10.2-0.40.3
Intermittent access terminal intake (last 3 days)0.00.00.0-0.0-0.1
Intermittent access total infusions0.10.10.20.4-0.3
Intermittent access day 1 locomotion0.10.20.30.10.6
Intermittent access day 15 total locomotion0.00.20.30.6-0.0
Intermittent access total locomotion0.20.30.50.70.0
Intermittent access standard deviation0.10.40.60.80.3
Left kidney weight5.342.451.47.2-5.8
Right kidney weight6.646.262.07.9-5.5
Cocaine induced anxiety0.61.62.91.7-0.6
Post-drug Anxiety0.10.10.20.4-0.2
Baseline Anxiety1.11.93.5-1.90.6
Tail length0.21.32.4-1.50.4
Length with tail0.31.51.81.1-1.3
Length without tail1.36.79.73.1-1.9
Times rat made contact with spout0.50.50.70.9-0.6
Lifetime Intake0.30.40.70.8-0.3
Liver weight, left1.93.35.11.2-2.3
Liver weight, right2.95.16.51.9-2.6
Locomotor activity2.43.74.32.1-1.8
Locomotor testing distance0.00.00.0-0.10.2
Locomotor testing rearing0.62.32.41.6-1.5
Locomotion in novel chamber0.50.71.3-1.1-0.3
Locomotion in novel chamber post-restriction0.20.50.8-0.90.5
Fecal boli incidents, locomotor time 10.00.10.1-0.20.4
Change in fecal boli incidents, locomotor task1.92.03.30.9-1.8
Time >=10cm from walls, locomotor time 10.20.20.40.6-0.3
Bouts of movement, locomotor time 10.81.11.41.2-0.8
Total resting periods, locomotor time 10.50.61.11.0-0.3
Rest time, locomotor task time 10.50.81.61.3-0.1
Distance moved, locomotor task time 10.10.30.5-0.0-0.7
Vertical activity count, locomotor time 10.00.10.1-0.30.1
Time >=10cm from walls, locomotor time 20.00.00.1-0.30.0
Bouts of movement, locomotor time 20.10.30.60.80.1
Total resting periods, locomotor time 20.10.30.60.70.2
Rest time, locomotor task time 20.00.10.10.20.2
Distance moved, locomotor task time 20.30.40.80.3-0.9
Vertical activity count, locomotor time 20.00.10.20.2-0.4
Light reinforcement 10.10.40.5-0.4-0.7
Light reinforcement 20.40.91.01.0-1.0
Bone: marrow area0.71.72.70.9-1.6
Bone: maximum diameter3.06.06.12.5-2.4
Bone: maximum force1.32.63.82.0-1.1
Bone: maximum moment1.63.04.32.1-1.3
Mean time between licks in bursts0.10.70.8-0.90.8
Mean num. licks in bursts0.82.32.91.7-1.3
Cd content in liver1.71.92.51.1-1.6
Co content in liver0.00.10.10.10.3
Cu content in liver6.88.19.8-3.12.5
Fe content in liver0.30.30.50.7-0.3
K content in liver1.31.31.4-1.21.1
Mg content in liver1.61.72.0-1.21.4
Mn content in liver0.10.10.2-0.1-0.5
Na content in liver2.32.63.1-1.81.5
Rb content in liver0.00.00.10.3-0.0
Se content in liver0.20.30.5-0.70.2
Sr content in liver2.82.42.8-1.71.4
Zn content in liver0.10.10.1-0.3-0.3
Bone: minimum diameter0.50.91.40.6-1.2
Time in familiar zone, hab. session 10.40.50.90.3-1.0
Time in novel zone, hab. session 10.10.10.20.5-0.1
Total zone transitions, hab. session 12.23.05.0-2.21.0
Total locomotion distance, hab. session 11.01.52.9-1.70.1
Locomotion velocity, hab. session 11.42.03.8-2.00.5
Time in familiar zone, hab. session 20.30.40.7-0.0-0.8
Time in novel zone, hab. session 20.10.20.3-0.00.5
Total zone transitions, hab. session 21.11.42.0-1.40.9
Total locomotion distance, hab. session 21.01.31.7-1.30.9
Locomotion velocity, hab. session 21.62.22.9-1.71.2
Novel to familiar place preference ratio2.43.13.31.7-1.8
Novelty place preference3.54.55.02.0-2.2
Time in novel zone, NPP test4.55.56.02.2-2.4
Total zone transitions, NPP test2.13.25.3-2.31.0
Total locomotion distance, NPP test1.11.62.3-1.50.9
Locomotion velocity, NPP test1.82.53.8-1.91.1
Intraocular pressure0.50.81.10.7-1.1
Delta distance traveled before/after self-admin0.91.01.80.4-1.3
Delta ambulatory time before/after self-admin0.71.22.10.5-1.5
Parametrial fat weight0.10.20.40.1-0.7
Pavlov. Cond. lever latency0.81.11.30.9-1.1
Pavlov. Cond. magazine entry latency0.70.91.3-0.71.1
Pavlov. Cond. change in total contacts1.81.92.4-1.21.5
Pavlov. Cond. index score0.60.81.3-0.51.1
Pavlov. Cond. latency score0.60.81.3-0.51.1
Pavlov. Cond. lever contacts2.22.73.1-1.51.8
Pavlov. Cond. magazine entry number0.70.91.40.6-1.2
Pavlov. Cond. intertrial magazine entries1.21.41.4-1.21.2
Pavlov. Cond. lever-magazine prob. diff.0.70.81.3-0.61.1
Pavlov. Cond. response bias1.11.42.0-0.91.4
Pavlov. Cond. lever latency1.62.23.11.1-1.8
Pavlov. Cond. magazine entry latency3.95.58.1-1.72.8
Pavlov. Cond. change in total contacts0.82.13.8-0.52.0
Pavlov. Cond. index score2.64.16.1-1.42.5
Pavlov. Cond. latency score3.15.17.4-1.72.7
Pavlov. Cond. lever contacts1.82.63.6-1.31.9
Pavlov. Cond. magazine entry number2.43.24.91.2-2.2
Pavlov. Cond. intertrial magazine entries0.92.02.71.6-1.2
Pavlov. Cond. lever-magazine prob. diff.2.84.36.3-1.52.5
Pavlov. Cond. response bias1.92.73.9-1.22.0
Time in closed arm before self-admin4.27.38.5-2.92.5
Time in closed arm after self-admin0.00.00.0-0.2-0.0
Time in open arm before self-admin0.20.20.30.4-0.5
Time in open arm after self-admin0.10.20.2-0.3-0.5
Bone: periosteal estimation1.12.53.21.3-1.8
Bone: periosteal perimeter3.67.08.42.4-2.9
Bone: post-yield work0.10.20.40.6-0.2
Progressive ratio test 1 active lever presses0.00.00.10.30.0
Progressive ratio test 1 breakpoint0.00.00.00.2-0.0
Progressive ratio test 1 inactive lever presses0.30.71.30.21.1
Progressive ratio test 2 active lever presses0.00.00.00.20.1
Progressive ratio test 2 breakpoint0.00.00.00.20.0
Progressive ratio test 2 inactive lever presses0.41.41.8-1.01.3
Incentive Sensitization - Responses0.00.10.1-0.20.3
Incentive Sensitization - Breakpoint0.00.00.0-0.10.2
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.1
Progressive ratio0.10.40.8-0.10.9
Food seeking constrained by brief footshock1.31.71.81.3-1.2
Seeking ratio, punishment vs. effort0.41.01.30.8-1.1
Retroperitoneal fat weight4.018.122.54.7-3.7
Reaction time number correct0.20.61.2-1.1-0.1
Reaction time mean minus median0.00.10.10.1-0.3
Reaction time mean minus median AUC0.10.70.90.9-0.8
Reaction time num false alarms0.10.20.3-0.5-0.4
Reaction time num false alarms AUC0.20.30.6-0.7-0.4
Reaction time trials correct on left0.20.61.2-1.1-0.1
Reaction time trials on left0.20.71.4-1.2-0.1
Reaction time mean0.20.40.4-0.60.6
Reaction time mean AUC0.10.30.3-0.50.5
Median of all reaction times0.40.70.7-0.80.9
Reaction time omissions0.30.40.8-0.9-0.1
Reaction time false alarm rate0.00.00.0-0.1-0.2
Reaction time premature initiation rate0.50.81.5-0.31.2
Reaction time premature initiations0.20.60.9-0.50.9
Std. dev. reaction times0.00.10.20.2-0.5
Reaction time trials completed0.20.71.4-1.2-0.1
Reaction time trials AUC0.10.51.0-1.0-0.1
Run reversals in cocaine runway, females0.50.51.0-1.0-0.3
Run reversals in cocaine runway, males1.81.93.20.8-1.8
Latency to leave start box in cocaine runway0.10.20.40.6-0.1
Latency to leave start box in cocaine runway, F0.00.00.1-0.10.2
Latency to leave start box in cocaine runway, M0.80.81.41.2-0.4
Std. dev. time between licks in bursts1.42.62.7-1.61.6
Total sessions with >9 infusions2.53.15.22.3-1.0
Short access day 1 total inactive lever presses0.20.30.60.80.2
Short access day 10 total inactive lever presses0.10.60.70.8-0.7
Short access day 1 total infusions0.20.51.01.0-0.1
Short access day 10 total infusions0.40.71.21.1-0.3
Short access total infusions0.81.12.11.4-0.3
Short access day 1 locomotion0.30.50.91.00.3
Short access day 10 total locomotion0.20.91.7-0.41.3
Short access total locomotion0.30.40.70.90.3
One hour access (0.3 mA shock)0.20.20.2-0.40.5
Compulsive drug intake0.10.10.2-0.40.0
One hour access (shock baseline)0.00.10.2-0.10.4
Social response proportion0.20.30.50.30.7
Social responses0.10.10.1-0.4-0.2
Social time1.62.52.5-1.61.6
Soleus weight0.10.30.3-0.60.5
Bone: stiffness0.61.11.71.3-0.7
Tibialis anterior weight0.93.03.4-1.61.8
Time to tail flick, vehicle, before self-admin0.00.00.00.00.0
Time to tail flick, vehicle, after self-admin0.40.71.5-1.20.0
Time to tail flick, test, before self-admin1.11.21.51.0-1.2
Time to tail flick, test, after self-admin0.20.20.4-0.7-0.1
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.1-0.0
Delta time to tail flick, test, before/after SA2.43.03.9-2.01.5
Tibia length0.92.62.71.6-1.6
Ambulatory time before self-admin0.30.91.3-0.71.1
Ambulatory time after self-admin0.91.42.0-1.40.9
Bone: tissue strength0.30.30.40.6-0.6
Total heroin consumption0.10.10.20.4-0.2
Bone: trabecular number0.00.10.2-0.0-0.4
Bone: trabecular spacing1.11.72.31.5-1.0
Bone: trabecular thickness0.50.70.9-0.71.0
Bone: trabecular tissue density2.85.06.3-1.92.5
Water consumed over 24 hours0.20.40.50.7-0.5
Number of responses in last shaping day2.63.45.7-1.12.4