Acd

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	intron excision ratio	chr19_50498332_50498560	0.53	0.18	8.4e-03	0.05	0.13	0.05	0.03	1.5e-02	3.1e-04	1.9e-02	4.5e-02
2	RMTg	intron excision ratio	chr19_50498011_50498145	0.59	0.16	1.5e-03	0.06	0.12	0.07	0.04	1.1e-02	3.8e-04	5.4e-03	3.4e-02
3	IC	gene expression	Acd	0.14	0.08	1.8e-07	0.15	0.14	0.15	0.16	6.0e-07	1.2e-06	1.1e-06	2.3e-07
4	BLA	gene expression	Acd	0.09	0.05	3.6e-06	0.09	0.11	0.09	0.08	1.5e-05	2.1e-06	2.7e-05	5.2e-05
5	Brain	gene expression	Acd	0.09	0.08	5.0e-04	0.02	0.03	0.03	0.03	2.5e-03	4.5e-04	6.5e-04	8.8e-04
6	Adipose	gene expression	Acd	0.04	0.03	3.7e-07	0.04	0.05	0.05	0.05	1.1e-05	2.2e-06	6.9e-06	3.0e-06
7	PL	gene expression	Acd	0.06	0.06	6.7e-05	0.04	0.03	0.03	0.04	1.9e-05	4.7e-04	8.6e-04	9.4e-05
8	pVTA	gene expression	Acd	0.04	0.03	3.1e-04	0.02	0.02	0.02	0.02	1.0e-02	4.7e-03	1.1e-02	1.6e-02
9	OFC	gene expression	Acd	0.51	0.21	9.9e-07	0.2	0.17	0.26	0.18	2.0e-05	8.7e-05	6.9e-07	5.1e-05
10	NAcc	alternative TSS	XM_008772496.4	0.02	0.02	4.6e-04	0.02	0.02	0.02	0.02	1.4e-04	3.1e-04	6.1e-04	2.7e-04
11	NAcc	alternative TSS	NM_001037193.1	0.02	0.01	1.2e-03	0.01	0.02	0.02	0.02	3.7e-03	8.4e-04	1.1e-03	1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.1	0.1	0.2	0.4	-0.4	0.4	0.4	0.5	-0.4	-0.3	0.3	-0.2	-0.2	-0.3
Area under the delay curve	0.1	0.2	0.8	-0.9	0.9	-0.4	0.0	-0.4	0.1	-0.0	-0.0	0.0	-0.0	-0.1
BMI with tail	0.1	0.2	0.6	-0.5	0.7	0.4	0.4	-0.1	-0.4	-0.8	0.5	-0.6	-0.4	-0.4
BMI without tail	0.1	0.3	1.6	-1.1	1.3	-0.2	-0.1	-0.5	0.0	-0.3	0.1	-0.3	-0.4	-0.0
Body weight	0.3	1.1	1.7	0.2	0.0	1.2	1.1	1.1	-1.2	-1.1	1.3	-1.3	-1.2	-0.9
Weight adjusted by age	0.0	0.0	0.1	0.1	-0.2	0.1	0.0	0.3	-0.0	-0.0	0.0	-0.1	-0.1	-0.1
Bone surface	1.0	1.9	3.1	0.5	-0.4	1.7	1.6	1.8	-1.6	-1.2	1.6	-1.3	-1.3	-1.4
Bone volume	0.8	1.6	3.3	0.5	-0.5	1.5	1.4	1.8	-1.4	-1.0	1.4	-1.2	-1.3	-1.3
Breakpoint value in progressive ratio session	1.2	2.2	2.5	1.5	-1.6	-1.4	-1.5	-1.0	1.5	1.5	-1.5	1.6	1.5	1.5
Number of licking bursts	0.2	0.7	1.2	0.5	-0.2	1.0	1.0	0.8	-1.1	-0.9	1.1	-0.9	-0.8	-0.7
Context. condit. distance diff. score	0.5	0.6	2.8	1.7	-1.6	-0.1	-0.3	0.3	0.2	0.7	-0.2	0.5	0.5	0.4
Locomotion velocity, session 1	0.2	0.3	1.3	-1.0	1.1	0.1	0.2	-0.4	-0.2	-0.3	0.3	-0.3	-0.2	-0.3
Locomotion distance, session 1	0.1	0.1	0.2	0.0	0.1	-0.4	-0.4	-0.4	0.3	0.4	-0.3	0.3	0.1	0.4
Locomotion velocity, session 2	0.8	1.0	1.6	1.2	-1.0	-0.9	-1.1	-0.7	0.9	1.3	-0.8	0.8	0.6	1.2
Locomotion distance, session 2	0.1	0.2	0.5	0.7	-0.5	-0.3	-0.5	-0.4	0.4	0.6	-0.2	0.3	0.1	0.7
Locomotion velocity, session 3	0.2	0.3	0.8	-0.0	0.1	-0.6	-0.5	-0.9	0.5	0.3	-0.5	0.6	0.7	0.5
Locomotion distance, session 3	0.2	0.2	0.8	0.9	-0.9	-0.3	-0.3	0.2	0.2	0.4	-0.3	0.3	0.3	0.3
Stereotopy head waving bouts, day 3	0.3	0.3	1.3	-1.1	1.1	0.3	0.3	-0.0	-0.3	-0.5	0.3	-0.5	-0.5	-0.5
Stereotopy head waving duration, day 3	0.5	0.6	0.8	-0.6	0.7	0.8	0.8	0.6	-0.8	-0.9	0.9	-0.9	-0.9	-0.8
Locomotion velocity, session 7	0.1	0.1	0.5	0.6	-0.7	0.0	-0.1	0.4	0.1	0.4	-0.2	0.4	0.3	0.0
Locomotion distance, session 7	0.2	0.2	0.9	0.8	-1.0	-0.2	-0.2	0.3	0.2	0.4	-0.3	0.5	0.3	0.2
Stereotopy head waving bouts, day 7	0.1	0.2	0.3	-0.0	0.1	0.5	0.5	0.3	-0.5	-0.6	0.5	-0.3	-0.2	-0.4
Stereotopy head waving duration, day 7	0.5	0.7	1.2	-0.7	0.9	0.9	1.0	0.3	-0.9	-1.1	0.9	-0.8	-0.6	-0.9
Locomotion velocity, session 8	0.1	0.1	0.6	0.7	-0.5	-0.0	-0.1	-0.3	0.0	0.1	0.0	0.2	0.3	0.3
Locomotion distance, session 8	0.8	1.1	3.3	1.8	-1.6	-0.6	-0.8	-0.4	0.7	1.1	-0.7	1.0	0.9	1.1
Degree of sensitization distance	0.0	0.0	0.1	-0.2	0.1	0.1	0.1	0.2	-0.1	-0.1	0.0	-0.0	-0.1	-0.2
Degree of sensitization stereotypy	0.3	0.3	0.6	-0.3	0.4	0.7	0.7	0.4	-0.6	-0.8	0.6	-0.5	-0.4	-0.6
Conditioned locomotion	1.8	2.1	3.7	0.6	-0.5	1.8	1.5	1.9	-1.6	-1.1	1.6	-1.5	-1.7	-1.2
Cocaine response after cond. corrected	1.0	1.5	6.0	-2.4	2.3	0.7	0.9	-0.1	-0.6	-1.3	0.6	-0.8	-0.6	-1.1
Cocaine response after cond. not corrected	0.7	1.0	5.0	-2.2	2.1	0.1	0.3	-0.8	-0.1	-0.9	0.0	-0.3	0.0	-0.6
Cocaine response before conditioning	1.2	1.4	2.2	0.7	-0.5	-1.4	-1.2	-1.5	1.2	1.1	-1.2	1.3	1.3	1.3
Saline control response	3.8	5.3	7.9	-1.1	1.4	2.5	2.3	2.0	-2.5	-2.3	2.7	-2.7	-2.8	-2.2
Bone: connectivity density	0.1	0.1	0.7	0.8	-0.7	-0.1	-0.2	-0.1	0.1	0.2	-0.1	0.3	0.3	0.3
Bone: cortical apparent density	0.6	0.9	1.6	0.2	-0.2	-1.2	-0.8	-1.1	1.0	0.6	-1.1	1.2	1.3	0.8
Bone: cortical area	0.3	0.4	1.3	-0.1	-0.1	0.8	0.7	1.1	-0.7	-0.4	0.6	-0.6	-0.6	-0.8
Bone: cortical porosity	0.4	0.5	1.1	1.0	-1.1	-0.4	-0.6	0.1	0.5	1.0	-0.5	0.6	0.3	0.7
Bone: cortical porosity	0.3	0.3	0.9	0.7	-0.8	-0.3	-0.6	-0.0	0.5	0.9	-0.5	0.6	0.4	0.5
Bone: cortical thickness	0.1	0.2	0.4	-0.3	0.1	0.4	0.5	0.7	-0.4	-0.3	0.4	-0.4	-0.4	-0.5
Bone: cortical thickness	0.5	0.6	2.6	1.3	-1.6	0.2	-0.1	1.2	-0.0	0.6	-0.1	0.0	-0.2	0.1
Bone: cortical tissue density	0.6	1.0	1.7	0.1	-0.2	-1.2	-0.9	-1.2	1.1	0.6	-1.1	1.2	1.3	0.8
Condit. Reinf. active minus inactive responses	3.4	3.9	5.4	0.4	-0.7	-2.2	-2.1	-1.9	2.3	2.2	-2.3	2.3	2.2	1.9
Condit. Reinf. active-inactive response ratio	3.2	3.4	4.9	0.5	-0.7	-2.1	-1.9	-1.8	2.1	2.0	-2.1	2.2	2.2	1.8
Condit. Reinf. active responses	2.4	3.1	4.5	0.6	-0.9	-2.0	-1.9	-1.5	2.0	2.1	-2.0	2.1	1.8	1.8
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.4	-0.6	-0.5	-0.5	-0.1	0.5	0.6	-0.5	0.5	0.4	0.5
Incentive salience index mean	1.8	2.3	3.5	0.6	-0.7	-1.6	-1.6	-1.3	1.7	1.9	-1.7	1.8	1.6	1.5
Condit. Reinf. lever presses	0.1	0.2	0.5	0.2	-0.2	-0.4	-0.5	-0.3	0.4	0.7	-0.4	0.5	0.3	0.4
Condit. Reinf. active minus inactive responses	0.5	0.8	1.0	-0.4	0.3	1.0	1.0	1.0	-1.0	-1.0	0.9	-1.0	-0.9	-1.0
Condit. Reinf. active-inactive response ratio	0.4	0.6	0.9	-0.5	0.4	0.8	0.9	0.8	-0.8	-0.9	0.8	-0.8	-0.7	-0.9
Condit. Reinf. active responses	0.3	0.4	0.8	0.1	-0.1	0.7	0.7	0.9	-0.7	-0.6	0.8	-0.8	-0.8	-0.6
Condit. Reinf. inactive responses	0.1	0.2	0.5	0.6	-0.6	-0.5	-0.6	-0.1	0.4	0.7	-0.4	0.3	0.1	0.5
Condit. Reinf. lever presses	3.0	4.4	9.2	3.0	-2.9	-1.9	-2.0	-1.0	1.7	2.2	-1.7	1.9	1.7	2.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.5	0.7	-0.7	0.2	0.2	0.6	-0.3	-0.0	0.3	-0.2	-0.3	-0.1
Conditioned reinforcement - actives	0.3	1.1	1.9	-1.0	0.9	-1.2	-1.1	-1.4	1.2	0.9	-1.1	0.9	0.7	0.9
Conditioned reinforcement - inactives	0.0	0.1	0.4	0.1	-0.1	0.4	0.5	0.1	-0.3	-0.7	0.2	0.0	0.3	-0.4
Conditioned locomotion	0.5	0.7	1.2	-0.2	0.2	1.1	1.1	0.7	-1.0	-1.1	0.9	-0.7	-0.6	-1.0
Patch foraging indifference point 0 sec	1.6	4.5	5.9	-0.8	0.9	2.3	2.3	2.2	-2.4	-2.2	2.4	-2.4	-2.4	-2.2
Patch foraging indifference point AUC	0.9	2.2	3.6	0.8	-0.6	1.7	1.5	1.9	-1.7	-1.2	1.8	-1.6	-1.7	-1.2
Delay disc. indifference point, 0s delay	0.6	0.7	1.8	-0.6	0.7	-1.1	-0.8	-1.3	0.8	0.5	-0.8	0.7	0.7	0.7
Delay disc. indifference point, 16s delay	0.3	0.5	2.1	-1.4	1.4	-0.0	0.2	0.0	-0.2	-0.0	0.3	-0.4	-0.7	-0.4
Delay disc. indifference point, 2s delay	0.1	0.2	0.4	0.4	-0.3	0.3	0.6	0.3	-0.5	-0.4	0.5	-0.1	-0.0	-0.4
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.1	-0.1	-0.1	0.0	0.1	-0.0	0.3	0.0	0.1	-0.2	0.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.7	0.1	-0.1	-0.8	-0.4	-0.7	0.5	0.1	-0.5	0.6	0.7	0.4
Delay disc. indifference point, 8s delay	0.1	0.2	1.2	-1.1	1.0	-0.4	0.0	-0.3	0.1	-0.1	-0.1	-0.0	-0.0	-0.2
Indifference point function ln k	0.2	0.6	1.3	-1.1	0.9	-0.7	-0.5	-1.0	0.8	0.2	-0.8	0.7	0.8	0.2
Indifference point function log k	0.2	0.6	1.3	-1.1	0.9	-0.7	-0.5	-1.0	0.8	0.2	-0.8	0.7	0.8	0.2
Patch foraging total patch changes 0 sec	1.5	4.5	6.0	-0.8	0.9	2.3	2.3	2.3	-2.3	-2.2	2.4	-2.4	-2.5	-2.2
Patch foraging total patch changes 12 sec	2.3	3.0	4.5	0.3	0.0	1.9	1.9	2.1	-2.1	-1.6	2.1	-2.0	-2.1	-1.6
Patch foraging total patch changes 18 sec	1.4	3.4	7.0	0.3	-0.4	2.1	1.9	2.6	-2.0	-1.4	2.0	-2.0	-2.2	-1.7
Patch foraging total patch changes 24 sec	0.3	0.9	4.0	2.0	-1.7	0.5	0.5	1.0	-0.7	-0.3	0.7	-0.4	-0.4	-0.1
Patch foraging total patch changes 6 sec	1.5	2.5	3.7	0.3	-0.0	1.7	1.7	1.7	-1.9	-1.7	1.9	-1.8	-1.7	-1.4
Patch foraging time to switch 0 sec	0.4	1.4	2.4	0.6	-0.4	-1.5	-1.3	-1.4	1.2	1.3	-1.2	1.3	1.3	1.3
Patch foraging water rate 0 sec	0.7	2.8	3.8	-1.2	1.2	1.9	1.7	1.6	-1.7	-1.7	1.7	-1.9	-2.0	-1.7
Patch foraging water rate 12 sec	0.0	0.2	0.4	0.2	-0.2	0.5	0.5	0.5	-0.5	-0.6	0.4	-0.4	-0.4	-0.4
Patch foraging water rate 18 sec	0.2	0.6	2.7	1.6	-1.6	0.2	0.3	0.7	-0.3	-0.2	0.1	0.1	0.2	-0.1
Patch foraging water rate 24 sec	0.1	0.1	0.3	-0.6	0.3	0.1	0.1	0.4	-0.1	-0.1	0.0	-0.2	-0.4	-0.3
Patch foraging water rate 6 sec	0.7	1.0	2.6	0.4	-0.6	1.2	1.1	1.6	-1.0	-0.9	0.9	-0.9	-0.8	-1.1
Seeking ratio, delayed vs. immediate footshock	1.9	2.8	3.6	-1.5	1.5	1.8	1.9	1.3	-1.8	-1.6	1.7	-1.6	-1.5	-1.9
Distance traveled before self-admin	1.4	3.0	12.9	3.4	-3.6	0.9	1.1	2.1	-1.0	-0.3	0.7	0.1	0.3	-0.6
Distance traveled after self-admin	0.1	0.2	0.4	0.7	-0.7	0.1	0.4	0.5	-0.4	-0.1	0.3	-0.0	-0.0	-0.3
Extensor digitorum longus weight	0.9	3.6	6.4	2.4	-2.5	-1.7	-1.9	-0.5	1.7	2.3	-1.7	1.8	1.5	1.9
Bone: elastic displacement	1.8	2.2	3.2	-1.8	1.6	1.4	1.5	1.1	-1.3	-1.8	1.3	-1.5	-1.3	-1.7
Bone: elastic work	0.7	0.9	1.3	-1.1	0.8	0.9	1.0	0.9	-0.8	-1.1	0.7	-0.9	-0.8	-1.1
Bone: endosteal estimation	0.0	0.1	0.3	-0.3	0.1	0.3	0.3	0.6	-0.3	-0.1	0.2	-0.3	-0.4	-0.4
Bone: endosteal perimeter	0.1	0.3	1.1	0.4	-0.5	0.7	0.5	1.0	-0.5	-0.0	0.5	-0.4	-0.5	-0.5
Epididymis fat weight	1.1	5.6	9.7	-0.0	-0.1	2.8	2.6	3.1	-2.6	-2.3	2.6	-2.5	-2.5	-2.5
Delta time in closed arm before/after self-admin	0.4	0.4	1.7	-1.2	1.3	0.2	0.3	-0.1	-0.3	-0.2	0.4	-0.5	-0.5	-0.4
Delta time in open arm before/after self-admin	0.4	0.5	1.9	1.3	-1.4	0.1	0.1	0.0	0.1	-0.4	-0.3	0.5	0.9	0.1
Diff in mean of infusions in LGA sessions	0.6	1.1	3.4	1.8	-1.7	-0.6	-0.8	-0.3	0.6	1.0	-0.6	0.9	0.9	1.0
Delay discount exponential model param	0.1	0.1	0.4	0.6	-0.6	0.5	0.1	0.5	-0.1	-0.1	0.1	-0.1	-0.1	-0.0
Extinction: sum of active levers before priming	0.4	0.6	1.0	-0.1	-0.0	-0.8	-0.9	-1.0	1.0	0.5	-0.9	0.7	0.8	0.8
Active lever presses in extinction session 6	0.2	0.2	1.0	-1.0	0.9	-0.1	0.0	0.0	-0.0	0.1	0.0	-0.2	-0.3	-0.2
Bone: final force	0.9	1.4	2.7	1.2	-1.3	-1.1	-1.3	-0.4	1.2	1.7	-1.2	1.3	1.0	1.2
Bone: final moment	0.3	0.5	1.2	0.5	-0.6	-0.8	-0.8	-0.3	0.8	1.1	-0.8	0.8	0.6	0.7
Food consumed during 24 hour testing period	0.2	0.3	1.0	0.8	-0.8	0.5	0.3	1.0	-0.5	-0.0	0.5	-0.5	-0.6	-0.2
Glucose	1.3	2.1	3.8	-0.2	0.2	-1.8	-1.5	-1.9	1.6	1.0	-1.6	1.6	1.6	1.4
Heart weight	0.1	0.1	0.5	-0.6	0.7	-0.2	-0.0	-0.5	0.1	-0.3	-0.1	0.1	0.1	-0.0
Delay discount hyperbolic model param	0.1	0.1	0.4	0.5	-0.6	0.6	0.2	0.6	-0.2	-0.2	0.2	-0.2	-0.2	-0.1
Intermittent access intake day 1-15 change	0.4	2.0	3.7	-0.2	0.2	-1.9	-1.7	-1.7	1.6	1.3	-1.6	1.3	1.2	1.5
Intermittent access intake escalation	0.4	2.2	3.9	-0.2	0.2	-2.0	-1.7	-1.8	1.7	1.4	-1.7	1.4	1.3	1.6
Intermittent access intake escalation 2	0.6	1.0	1.8	-0.7	0.7	-1.3	-1.2	-1.3	1.2	0.8	-1.1	0.8	0.8	1.0
Intermitt. access day 1 inactive lever presses	0.0	0.3	1.6	-1.0	1.3	-0.3	-0.2	-1.0	0.2	-0.1	-0.1	-0.0	0.0	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.4	1.1	1.1	-1.1	-0.2	-0.2	-0.2	0.3	0.4	-0.4	0.8	0.9	0.3
Intermitt. access escalation Index	0.1	0.5	1.1	-1.0	1.1	0.4	0.6	0.2	-0.6	-0.6	0.6	-0.7	-0.6	-0.7
Intermittent access day 1 total infusions	0.6	1.7	8.6	-2.8	2.9	-0.3	-0.1	-1.3	0.2	-0.2	-0.1	-0.2	-0.2	-0.2
Intermittent access day 15 total infusions	1.2	3.0	6.4	-2.3	2.3	-2.0	-1.6	-2.5	1.7	1.0	-1.6	1.1	1.1	1.2
Intermittent access terminal intake (last 3 days)	2.0	3.6	7.1	-1.7	1.7	-2.3	-2.0	-2.7	2.1	1.5	-2.0	1.5	1.5	1.6
Intermittent access total infusions	2.4	2.9	5.5	-2.0	2.0	-1.9	-1.7	-2.3	1.8	1.3	-1.7	1.2	1.1	1.2
Intermittent access day 1 locomotion	1.7	3.2	10.0	-3.1	3.2	1.1	1.3	0.1	-1.2	-1.7	1.3	-1.5	-1.4	-1.6
Intermittent access day 15 total locomotion	0.4	1.4	5.4	-2.3	2.3	0.4	0.7	-0.4	-0.5	-1.2	0.6	-0.8	-0.6	-0.9
Intermittent access total locomotion	1.3	1.5	7.3	-2.7	2.7	0.1	0.4	-0.8	-0.2	-0.8	0.2	-0.4	-0.3	-0.7
Intermittent access standard deviation	0.1	0.3	0.7	-0.8	0.8	0.5	0.6	0.2	-0.5	-0.8	0.5	-0.6	-0.4	-0.6
Left kidney weight	1.4	11.4	28.1	5.3	-5.1	-2.7	-2.8	-1.3	2.6	3.2	-2.6	3.2	3.1	3.3
Right kidney weight	1.7	11.8	30.2	5.5	-5.4	-2.7	-2.8	-1.1	2.6	3.3	-2.7	3.1	3.0	3.3
Cocaine induced anxiety	1.2	3.4	5.0	-1.3	1.4	2.0	2.0	1.3	-2.0	-2.2	2.0	-2.0	-1.8	-2.0
Post-drug Anxiety	0.5	0.6	1.4	-0.6	0.7	0.8	0.9	0.2	-0.8	-1.2	0.8	-0.8	-0.7	-0.8
Baseline Anxiety	1.0	1.6	2.5	0.1	-0.1	-1.6	-1.4	-1.5	1.4	1.3	-1.4	1.3	1.3	1.3
Tail length	0.0	0.1	0.2	-0.2	0.3	-0.1	-0.1	0.1	-0.0	0.3	0.1	-0.2	-0.5	0.1
Length with tail	0.2	0.8	1.8	1.3	-1.2	0.7	0.6	1.3	-0.8	-0.3	0.8	-0.7	-0.9	-0.4
Length without tail	0.3	1.4	2.3	0.8	-0.7	1.3	1.2	1.5	-1.3	-1.2	1.3	-1.3	-1.1	-1.0
Times rat made contact with spout	1.2	1.3	1.9	-0.6	0.6	1.2	1.2	1.3	-1.3	-1.0	1.3	-1.3	-1.4	-1.2
Lifetime Intake	2.0	2.5	4.4	-2.0	1.9	-1.8	-1.6	-2.1	1.6	1.2	-1.5	1.1	0.9	1.1
Liver weight, left	0.2	0.4	0.6	0.7	-0.5	0.6	0.6	0.7	-0.7	-0.5	0.7	-0.6	-0.6	-0.4
Liver weight, right	0.4	0.7	1.1	0.5	-0.4	0.9	0.7	1.0	-0.9	-0.6	1.0	-1.0	-1.0	-0.6
Locomotor activity	2.3	3.6	6.0	-0.1	-0.0	2.3	2.1	2.4	-2.1	-1.8	2.1	-2.0	-2.1	-2.0
Locomotor testing distance	1.5	3.6	5.3	-1.2	1.1	2.1	2.0	2.0	-2.0	-1.8	2.0	-2.1	-2.3	-2.0
Locomotor testing rearing	0.2	0.6	1.5	0.4	-0.6	1.0	0.7	1.2	-0.7	-0.5	0.6	-0.7	-0.9	-0.7
Locomotion in novel chamber	1.9	2.6	3.5	-1.4	1.4	1.7	1.8	1.3	-1.7	-1.7	1.7	-1.6	-1.4	-1.9
Locomotion in novel chamber post-restriction	1.1	3.3	5.2	-2.3	2.2	1.5	1.6	1.3	-1.6	-1.6	1.7	-2.0	-2.1	-1.8
Fecal boli incidents, locomotor time 1	0.6	1.5	3.8	-1.0	1.1	0.8	0.9	1.1	-1.1	-1.1	1.2	-1.6	-2.0	-0.9
Change in fecal boli incidents, locomotor task	0.5	0.6	1.1	0.6	-0.5	-0.7	-0.7	-1.1	0.7	0.4	-0.7	0.8	1.1	0.8
Time >=10cm from walls, locomotor time 1	0.8	0.9	2.6	-1.5	1.6	0.4	0.5	0.2	-0.6	-0.8	0.7	-1.1	-1.3	-0.6
Bouts of movement, locomotor time 1	0.4	0.5	2.4	-1.4	1.5	0.2	0.2	-0.5	-0.3	-0.6	0.3	-0.5	-0.5	-0.3
Total resting periods, locomotor time 1	0.3	0.4	2.0	-1.3	1.4	-0.1	-0.0	-0.7	0.0	-0.3	0.0	-0.2	-0.1	-0.0
Rest time, locomotor task time 1	0.5	0.7	3.3	-1.6	1.8	-0.4	-0.3	-1.4	0.4	-0.2	-0.2	0.1	0.2	0.2
Distance moved, locomotor task time 1	0.1	0.2	0.6	0.5	-0.6	0.4	0.4	0.8	-0.3	-0.3	0.3	-0.2	-0.0	-0.4
Vertical activity count, locomotor time 1	0.1	0.9	3.0	0.0	-0.4	1.0	1.0	1.7	-1.0	-0.6	0.9	-0.9	-1.0	-1.1
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.1	0.0	-0.6	-0.7	-0.6	0.6	0.3	-0.6	0.4	0.3	0.6
Bouts of movement, locomotor time 2	0.2	0.8	1.2	0.2	-0.2	-1.0	-1.0	-1.0	1.0	1.1	-0.9	1.0	0.9	0.9
Total resting periods, locomotor time 2	0.3	1.0	1.4	0.5	-0.4	-1.1	-1.1	-1.1	1.1	1.2	-1.1	1.1	1.0	1.1
Rest time, locomotor task time 2	0.4	0.7	1.7	-0.9	1.0	-1.0	-0.9	-1.3	0.9	0.5	-0.8	0.5	0.2	0.8
Distance moved, locomotor task time 2	0.6	0.8	1.7	0.6	-0.8	1.1	1.0	1.3	-0.9	-1.0	0.7	-0.6	-0.2	-1.0
Vertical activity count, locomotor time 2	0.5	1.2	2.7	0.3	-0.5	1.4	1.3	1.7	-1.2	-1.0	1.1	-1.0	-0.8	-1.2
Light reinforcement 1	1.0	4.5	8.7	0.3	-0.4	2.7	2.4	3.0	-2.4	-1.7	2.3	-2.1	-2.2	-2.2
Light reinforcement 2	1.3	2.9	4.3	-0.5	0.4	1.9	2.0	2.1	-1.9	-1.6	1.9	-1.7	-1.8	-1.9
Bone: marrow area	0.0	0.1	0.2	-0.4	0.2	0.3	0.2	0.5	-0.2	-0.1	0.2	-0.2	-0.4	-0.4
Bone: maximum diameter	0.3	0.6	1.2	-0.4	0.2	1.0	0.8	1.1	-0.8	-0.6	0.8	-0.8	-0.8	-0.9
Bone: maximum force	0.3	0.5	1.0	0.8	-1.0	-0.6	-0.6	-0.1	0.7	0.9	-0.7	0.8	0.7	0.6
Bone: maximum moment	0.0	0.1	0.1	0.1	-0.3	-0.2	-0.2	0.0	0.2	0.3	-0.3	0.3	0.3	0.1
Mean time between licks in bursts	0.0	0.1	0.3	0.4	-0.6	0.1	0.1	0.3	0.0	0.0	-0.1	0.2	0.3	-0.1
Mean num. licks in bursts	0.0	0.1	0.5	-0.7	0.4	-0.1	-0.1	0.2	0.1	0.2	-0.2	-0.0	-0.2	-0.2
Cd content in liver	0.1	0.1	0.3	0.5	-0.6	-0.2	-0.2	-0.1	0.3	0.2	-0.3	0.3	0.5	0.2
Co content in liver	0.0	0.0	0.1	-0.4	0.1	-0.2	-0.2	0.1	0.3	0.1	-0.3	0.1	0.1	0.0
Cu content in liver	0.7	0.9	1.3	0.5	-0.5	-1.0	-1.1	-0.9	1.0	1.1	-1.0	0.9	0.8	1.1
Fe content in liver	2.1	2.6	3.5	-1.4	1.3	1.6	1.6	1.5	-1.6	-1.7	1.6	-1.8	-1.9	-1.7
K content in liver	0.2	0.2	0.5	-0.5	0.5	-0.4	-0.4	-0.7	0.4	-0.1	-0.3	0.2	0.3	0.3
Mg content in liver	0.5	0.5	0.9	-0.9	1.0	0.6	0.6	0.2	-0.6	-0.9	0.7	-0.8	-0.7	-0.6
Mn content in liver	0.7	0.7	1.4	-0.9	1.0	0.8	0.9	0.3	-0.8	-1.2	0.8	-0.8	-0.7	-0.9
Na content in liver	0.4	0.4	1.5	-1.2	1.2	-0.1	0.0	-0.6	0.0	-1.0	-0.0	-0.3	-0.1	-0.2
Rb content in liver	0.3	0.3	0.8	-0.2	0.2	-0.5	-0.6	-0.7	0.6	0.9	-0.5	0.6	0.4	0.5
Se content in liver	0.1	0.1	0.2	0.1	-0.5	-0.2	-0.2	0.4	0.3	0.5	-0.4	0.4	0.2	0.0
Sr content in liver	0.8	0.7	1.1	0.2	-0.1	1.0	0.9	1.1	-1.0	-0.7	1.0	-0.8	-0.9	-0.8
Zn content in liver	1.4	1.6	2.5	0.6	-0.9	-1.4	-1.5	-0.9	1.5	1.3	-1.6	1.4	1.3	1.3
Bone: minimum diameter	0.2	0.3	0.7	-0.8	0.6	0.5	0.5	0.7	-0.4	-0.3	0.4	-0.5	-0.5	-0.7
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.8	0.7	0.3	0.6	0.2	-0.4	-0.7	0.4	-0.4	-0.2	-0.7
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.0	-0.1	-0.3	-0.5	-0.3	0.4	0.5	-0.4	0.3	0.2	0.4
Total zone transitions, hab. session 1	0.7	1.0	1.7	-0.3	0.5	1.1	1.0	0.8	-1.1	-0.9	1.2	-1.2	-1.3	-0.9
Total locomotion distance, hab. session 1	0.9	1.3	2.2	-0.1	0.1	1.4	1.1	1.3	-1.3	-1.0	1.3	-1.3	-1.5	-1.1
Locomotion velocity, hab. session 1	1.1	1.6	2.8	0.0	0.1	1.5	1.2	1.4	-1.4	-1.0	1.5	-1.4	-1.7	-1.1
Time in familiar zone, hab. session 2	1.2	1.3	3.5	-1.9	1.7	0.9	1.1	0.5	-0.9	-1.2	0.8	-0.9	-0.7	-1.3
Time in novel zone, hab. session 2	3.5	3.8	4.9	1.2	-1.2	-2.2	-2.2	-1.9	2.1	2.0	-2.1	2.0	1.9	2.2
Total zone transitions, hab. session 2	1.7	2.2	3.8	-0.0	0.3	1.7	1.5	1.6	-1.7	-1.2	1.8	-1.7	-1.9	-1.3
Total locomotion distance, hab. session 2	1.0	1.3	2.4	0.1	0.0	1.3	1.1	1.4	-1.3	-0.8	1.3	-1.3	-1.5	-1.0
Locomotion velocity, hab. session 2	0.9	1.3	2.3	0.6	-0.4	1.3	1.0	1.5	-1.3	-0.6	1.3	-1.2	-1.5	-0.9
Novel to familiar place preference ratio	1.5	2.0	3.7	0.5	-0.4	-1.5	-1.4	-1.8	1.5	1.1	-1.5	1.6	1.9	1.4
Novelty place preference	2.4	3.0	5.1	0.5	-0.4	-1.9	-1.7	-2.2	1.9	1.4	-1.9	2.0	2.3	1.7
Time in novel zone, NPP test	2.2	2.7	4.6	0.3	-0.3	-1.8	-1.6	-2.1	1.8	1.4	-1.8	1.9	2.1	1.6
Total zone transitions, NPP test	1.4	2.1	3.5	-0.0	0.2	1.6	1.5	1.6	-1.7	-1.3	1.7	-1.7	-1.9	-1.3
Total locomotion distance, NPP test	0.9	1.2	2.5	0.6	-0.5	1.2	1.0	1.6	-1.2	-0.6	1.2	-1.2	-1.5	-0.8
Locomotion velocity, NPP test	0.8	1.1	2.4	0.8	-0.7	1.1	0.9	1.6	-1.1	-0.5	1.2	-1.1	-1.4	-0.7
Intraocular pressure	0.7	1.1	3.1	1.7	-1.8	-0.5	-0.8	0.0	0.8	1.3	-0.8	1.0	0.8	0.9
Delta distance traveled before/after self-admin	0.4	0.4	1.5	-0.5	0.7	-0.6	-0.7	-1.2	0.7	0.3	-0.6	0.5	0.6	0.7
Delta ambulatory time before/after self-admin	0.6	1.0	2.8	-1.1	1.3	-1.1	-1.0	-1.7	1.0	0.5	-0.8	0.5	0.5	0.8
Parametrial fat weight	6.0	14.1	17.5	-2.2	2.2	3.9	4.1	3.6	-4.1	-4.1	4.1	-4.2	-4.1	-4.0
Pavlov. Cond. lever latency	0.3	0.4	2.1	-1.4	1.3	0.2	0.3	-0.3	-0.1	-0.6	0.1	-0.2	-0.0	-0.5
Pavlov. Cond. magazine entry latency	0.9	1.1	2.6	1.5	-1.6	-0.7	-1.0	0.0	0.9	1.5	-0.8	0.9	0.5	1.0
Pavlov. Cond. change in total contacts	1.1	1.1	2.3	1.5	-1.4	-1.0	-1.0	-0.6	0.9	1.2	-0.9	1.1	0.8	1.1
Pavlov. Cond. index score	1.0	1.3	4.6	2.1	-2.0	-0.6	-0.9	0.2	0.6	1.4	-0.6	0.8	0.4	1.0
Pavlov. Cond. latency score	0.8	1.1	3.8	2.0	-1.9	-0.5	-0.8	0.2	0.5	1.3	-0.5	0.7	0.3	0.9
Pavlov. Cond. lever contacts	0.9	1.1	3.2	1.8	-1.7	-0.7	-0.9	-0.2	0.7	1.2	-0.7	0.8	0.6	1.1
Pavlov. Cond. magazine entry number	0.8	1.1	2.1	-1.4	1.4	0.8	1.1	0.1	-0.9	-1.4	0.9	-0.9	-0.5	-1.1
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.5	-1.2	0.9	0.4	0.5	0.5	-0.3	-0.5	0.2	-0.4	-0.4	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	4.7	2.2	-2.0	-0.6	-0.9	0.1	0.6	1.4	-0.6	0.8	0.4	1.1
Pavlov. Cond. response bias	0.6	0.7	2.2	1.5	-1.4	-0.5	-0.7	0.1	0.6	1.1	-0.5	0.6	0.3	0.8
Pavlov. Cond. lever latency	1.5	2.1	3.5	-1.9	1.8	1.4	1.4	0.7	-1.3	-1.6	1.3	-1.4	-1.2	-1.5
Pavlov. Cond. magazine entry latency	2.9	4.1	5.8	1.7	-1.8	-2.1	-2.1	-1.4	2.1	2.4	-2.1	2.2	2.0	2.1
Pavlov. Cond. change in total contacts	1.6	3.9	8.1	2.7	-2.8	-1.7	-1.8	-0.5	1.7	2.2	-1.7	1.9	1.6	1.9
Pavlov. Cond. index score	3.0	4.7	6.4	2.2	-2.3	-2.2	-2.2	-1.3	2.1	2.5	-2.2	2.3	2.0	2.3
Pavlov. Cond. latency score	2.9	4.7	6.3	2.2	-2.2	-2.2	-2.2	-1.4	2.1	2.5	-2.1	2.3	2.1	2.3
Pavlov. Cond. lever contacts	1.9	2.8	4.8	2.2	-2.2	-1.6	-1.6	-0.7	1.5	1.9	-1.5	1.5	1.3	1.8
Pavlov. Cond. magazine entry number	4.9	6.4	8.7	-2.1	2.2	2.6	2.7	1.8	-2.6	-2.9	2.7	-2.8	-2.6	-2.6
Pavlov. Cond. intertrial magazine entries	2.8	6.2	8.3	-1.4	1.3	2.8	2.6	2.7	-2.6	-2.4	2.6	-2.8	-2.9	-2.6
Pavlov. Cond. lever-magazine prob. diff.	3.3	5.1	6.9	2.1	-2.2	-2.4	-2.4	-1.5	2.3	2.6	-2.3	2.4	2.2	2.4
Pavlov. Cond. response bias	3.3	4.6	6.4	2.4	-2.5	-2.1	-2.2	-1.1	2.0	2.5	-2.1	2.2	2.0	2.2
Time in closed arm before self-admin	1.8	3.2	4.6	-0.3	0.6	2.1	1.9	1.6	-2.1	-2.1	2.1	-2.1	-1.9	-1.7
Time in closed arm after self-admin	2.4	2.8	4.3	-0.4	0.8	1.8	1.9	1.4	-2.0	-1.8	2.1	-1.9	-1.8	-1.7
Time in open arm before self-admin	2.0	2.4	4.2	1.8	-2.0	-1.5	-1.5	-0.4	1.4	1.9	-1.5	1.5	1.2	1.5
Time in open arm after self-admin	0.9	0.9	2.2	1.1	-1.5	-0.7	-0.8	-0.2	0.9	0.7	-1.1	1.1	1.2	0.7
Bone: periosteal estimation	0.2	0.4	1.5	-0.1	-0.2	0.8	0.7	1.2	-0.6	-0.3	0.6	-0.6	-0.7	-0.8
Bone: periosteal perimeter	0.5	1.0	2.5	0.2	-0.3	1.2	1.0	1.6	-1.0	-0.6	1.0	-0.9	-1.0	-1.0
Bone: post-yield work	0.5	0.8	1.1	-1.0	1.0	0.9	1.0	0.4	-0.9	-1.0	0.9	-0.8	-0.7	-1.0
Progressive ratio test 1 active lever presses	1.7	3.0	4.4	-0.6	0.4	-2.1	-2.0	-1.9	2.0	2.1	-2.0	1.7	1.5	1.7
Progressive ratio test 1 breakpoint	1.6	2.7	3.9	-0.5	0.4	-1.9	-1.9	-1.8	1.9	2.0	-1.9	1.6	1.4	1.6
Progressive ratio test 1 inactive lever presses	0.3	0.7	3.3	-1.8	1.8	-0.5	-0.3	-1.0	0.3	-0.0	-0.2	-0.0	-0.2	0.0
Progressive ratio test 2 active lever presses	2.0	2.8	5.0	-2.2	2.1	-1.9	-1.7	-2.2	1.7	1.2	-1.6	1.0	0.8	1.3
Progressive ratio test 2 breakpoint	2.2	2.8	5.0	-2.1	2.0	-2.0	-1.8	-2.2	1.7	1.3	-1.6	1.0	0.8	1.3
Progressive ratio test 2 inactive lever presses	0.2	0.6	2.5	-1.6	1.5	-0.5	-0.3	-1.0	0.4	-0.0	-0.4	0.3	0.3	0.0
Incentive Sensitization - Responses	0.5	1.5	4.4	-2.0	2.1	-1.3	-1.0	-1.6	1.0	0.5	-0.8	0.3	0.2	0.7
Incentive Sensitization - Breakpoint	0.7	1.7	4.8	-2.1	2.2	-1.4	-1.1	-1.8	1.1	0.6	-0.9	0.3	0.2	0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	0.5	-0.6	-0.4	-0.4	-0.4	0.5	0.5	-0.6	0.7	0.8	0.4
Progressive ratio	1.0	2.9	14.2	3.8	-3.7	0.3	0.1	1.3	-0.2	0.9	0.0	0.7	0.7	0.4
Food seeking constrained by brief footshock	2.3	2.9	7.3	2.7	-2.6	-1.4	-1.4	-0.7	1.3	1.5	-1.3	1.5	1.6	1.7
Seeking ratio, punishment vs. effort	0.4	0.8	2.1	-1.0	1.0	-1.1	-1.0	-1.4	0.9	0.2	-0.9	0.5	0.7	0.8
Retroperitoneal fat weight	5.3	23.8	30.0	-2.9	2.9	5.3	5.5	4.8	-5.3	-5.2	5.2	-5.2	-5.0	-5.4
Reaction time number correct	0.4	1.6	2.2	-0.1	0.1	-1.4	-1.5	-1.5	1.5	1.4	-1.4	1.2	1.2	1.3
Reaction time mean minus median	0.3	2.0	4.7	2.1	-2.2	-0.8	-1.2	-0.3	1.1	1.7	-1.2	1.5	1.4	1.3
Reaction time mean minus median AUC	0.3	2.1	5.9	2.4	-2.4	-0.6	-1.0	-0.1	1.0	1.7	-1.0	1.3	1.2	1.2
Reaction time num false alarms	0.1	0.2	0.6	-0.1	0.2	-0.4	-0.3	-0.8	0.4	0.1	-0.4	0.4	0.5	0.3
Reaction time num false alarms AUC	0.0	0.1	0.3	-0.5	0.6	0.0	0.0	-0.3	-0.0	-0.3	0.1	-0.2	-0.1	-0.1
Reaction time trials correct on left	0.4	1.6	2.2	-0.1	0.1	-1.4	-1.5	-1.5	1.5	1.4	-1.4	1.2	1.2	1.3
Reaction time trials on left	0.5	1.6	2.3	-0.1	0.0	-1.5	-1.5	-1.5	1.5	1.4	-1.5	1.3	1.2	1.3
Reaction time mean	0.7	1.6	7.5	2.7	-2.7	0.2	-0.0	0.6	0.1	0.5	-0.2	0.8	1.0	0.4
Reaction time mean AUC	0.6	1.5	6.7	2.6	-2.6	-0.1	-0.3	0.2	0.4	0.6	-0.4	1.0	1.2	0.6
Median of all reaction times	0.8	1.2	5.9	2.4	-2.4	0.5	0.4	0.7	-0.3	-0.0	0.2	0.4	0.7	0.0
Reaction time omissions	0.1	0.2	0.6	0.4	-0.4	0.3	0.1	0.8	-0.2	0.4	0.3	-0.3	-0.6	-0.1
Reaction time false alarm rate	0.3	0.5	0.9	-0.5	0.6	0.7	0.7	0.3	-0.7	-0.9	0.7	-0.7	-0.6	-0.7
Reaction time premature initiation rate	1.3	2.0	3.3	1.7	-1.8	-1.2	-1.3	-0.7	1.3	1.5	-1.3	1.5	1.4	1.4
Reaction time premature initiations	1.2	3.7	4.7	1.5	-1.6	-2.0	-2.1	-1.5	2.0	2.2	-2.1	2.1	2.0	2.1
Std. dev. reaction times	0.3	1.1	4.3	2.0	-2.1	-0.2	-0.5	0.2	0.5	0.8	-0.5	0.9	1.0	0.6
Reaction time trials completed	0.5	1.6	2.3	-0.1	0.0	-1.5	-1.5	-1.5	1.5	1.4	-1.5	1.3	1.2	1.3
Reaction time trials AUC	0.5	1.6	2.3	-0.1	0.0	-1.5	-1.5	-1.4	1.5	1.4	-1.5	1.3	1.2	1.3
Run reversals in cocaine runway, females	1.7	1.9	2.8	-1.2	1.1	1.4	1.3	1.2	-1.3	-1.7	1.3	-1.6	-1.6	-1.4
Run reversals in cocaine runway, males	0.5	0.6	1.6	-0.8	0.7	0.6	0.5	0.8	-0.6	-0.6	0.7	-1.0	-1.2	-0.6
Latency to leave start box in cocaine runway	0.1	0.2	0.5	0.1	-0.1	-0.1	-0.4	-0.7	0.5	-0.0	-0.5	0.4	0.7	0.4
Latency to leave start box in cocaine runway, F	1.3	1.6	4.2	-1.8	1.7	-1.2	-1.1	-2.1	1.2	0.3	-1.2	0.8	1.0	0.8
Latency to leave start box in cocaine runway, M	2.0	1.9	5.6	2.4	-2.3	1.6	1.1	1.7	-1.1	-0.6	1.0	-0.5	-0.3	-0.6
Std. dev. time between licks in bursts	1.1	2.1	3.9	0.3	-0.4	1.8	1.6	2.0	-1.6	-1.3	1.6	-1.5	-1.5	-1.5
Total sessions with >9 infusions	1.4	1.7	2.4	-1.6	1.3	-1.6	-1.4	-1.4	1.5	1.3	-1.5	1.0	0.7	0.9
Short access day 1 total inactive lever presses	0.3	0.6	3.2	-1.8	1.6	-0.2	0.1	-0.3	0.0	-0.3	-0.0	-0.2	-0.3	-0.4
Short access day 10 total inactive lever presses	0.0	0.3	0.5	-0.6	0.7	0.5	0.5	0.2	-0.5	-0.6	0.6	-0.7	-0.7	-0.5
Short access day 1 total infusions	0.7	1.4	6.2	-2.5	2.3	-1.0	-0.7	-1.1	0.7	0.4	-0.7	0.1	-0.1	0.2
Short access day 10 total infusions	0.8	1.3	5.2	-2.3	2.3	-0.8	-0.7	-1.3	0.7	0.5	-0.6	0.2	0.1	0.3
Short access total infusions	1.8	2.5	4.1	-2.0	1.9	-1.8	-1.6	-1.9	1.6	1.4	-1.6	1.1	0.9	1.1
Short access day 1 locomotion	0.2	0.4	1.3	-1.2	1.0	-0.7	-0.6	-0.5	0.5	0.4	-0.5	0.1	-0.2	0.3
Short access day 10 total locomotion	0.9	3.4	6.9	-2.6	2.5	1.7	1.8	0.9	-1.6	-1.9	1.6	-1.6	-1.6	-2.1
Short access total locomotion	0.8	1.1	4.8	-2.2	2.1	0.4	0.7	-0.0	-0.5	-0.8	0.5	-0.6	-0.6	-1.0
One hour access (0.3 mA shock)	1.3	1.5	2.9	-1.6	1.7	-1.4	-1.2	-1.7	1.2	1.0	-1.1	0.7	0.5	0.9
Compulsive drug intake	0.2	0.3	0.9	0.9	-0.9	0.4	0.4	0.9	-0.4	-0.2	0.4	-0.3	-0.4	-0.2
One hour access (shock baseline)	0.9	2.4	6.2	-2.4	2.5	-1.5	-1.3	-2.2	1.3	0.8	-1.1	0.7	0.7	0.9
Social response proportion	0.7	0.8	1.6	-1.1	1.1	-1.0	-0.9	-1.3	0.9	0.7	-0.9	0.7	0.7	0.6
Social responses	0.1	0.1	0.4	-0.6	0.5	-0.2	-0.1	-0.1	0.2	0.2	-0.1	-0.0	-0.1	-0.0
Social time	0.2	0.3	1.5	-1.2	1.0	-0.2	-0.2	-0.3	0.3	0.1	-0.3	0.1	0.0	-0.1
Soleus weight	0.2	0.5	1.2	0.3	-0.4	0.7	0.8	1.1	-0.8	-0.6	0.7	-0.6	-0.7	-0.7
Bone: stiffness	3.1	5.6	7.8	2.6	-2.6	-2.2	-2.4	-1.4	2.3	2.8	-2.3	2.5	2.3	2.4
Tibialis anterior weight	0.5	1.6	4.8	2.2	-2.1	-0.7	-1.0	0.1	0.8	1.6	-0.8	0.9	0.5	1.2
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.1	-1.1	1.0	-1.0	-0.8	-1.0	0.8	0.6	-0.7	0.4	0.2	0.5
Time to tail flick, vehicle, after self-admin	1.3	2.7	9.4	-3.1	3.0	0.9	1.0	0.3	-0.9	-1.1	1.0	-1.4	-1.5	-1.4
Time to tail flick, test, before self-admin	2.4	2.8	4.2	-1.1	1.4	1.6	1.7	1.4	-1.8	-1.5	1.9	-2.0	-2.1	-1.6
Time to tail flick, test, after self-admin	0.3	0.4	1.8	-1.3	1.2	0.1	0.2	0.1	-0.2	0.1	0.2	-0.3	-0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	1.6	1.7	5.3	-2.3	2.1	1.1	0.9	0.7	-0.8	-0.8	0.8	-1.2	-1.3	-1.3
Delta time to tail flick, test, before/after SA	0.9	1.1	1.7	0.3	-0.6	-1.1	-1.1	-0.7	1.2	1.3	-1.2	1.3	1.1	0.9
Tibia length	0.1	0.2	0.7	0.8	-0.8	-0.1	-0.3	0.1	0.2	0.5	-0.1	0.2	0.1	0.3
Ambulatory time before self-admin	0.8	2.5	7.3	2.5	-2.7	1.3	1.4	2.3	-1.3	-0.7	1.1	-0.5	-0.3	-1.0
Ambulatory time after self-admin	0.3	0.4	1.0	1.0	-1.0	0.3	0.7	0.9	-0.7	-0.5	0.6	-0.3	-0.2	-0.5
Bone: tissue strength	0.8	0.9	3.2	-1.8	1.8	-0.6	-0.3	-1.4	0.5	-0.3	-0.5	0.4	0.6	0.1
Total heroin consumption	0.8	1.0	2.0	-0.3	0.3	-1.2	-1.1	-1.4	1.1	0.8	-1.1	1.0	1.1	1.0
Bone: trabecular number	0.2	0.4	0.7	0.2	-0.2	0.8	0.8	0.7	-0.8	-0.7	0.8	-0.6	-0.5	-0.6
Bone: trabecular spacing	0.1	0.1	0.4	-0.6	0.5	0.1	0.2	0.2	-0.2	-0.2	0.2	-0.4	-0.4	-0.3
Bone: trabecular thickness	0.5	0.7	1.4	1.2	-1.2	-0.7	-0.7	-0.3	0.7	0.9	-0.8	0.9	0.8	0.8
Bone: trabecular tissue density	0.5	0.8	1.2	0.5	-0.4	-1.0	-1.0	-1.1	1.0	0.9	-0.9	1.0	1.0	1.0
Water consumed over 24 hours	0.1	0.3	0.5	0.3	-0.1	0.5	0.5	0.7	-0.7	-0.3	0.7	-0.6	-0.7	-0.4
Number of responses in last shaping day	1.7	2.2	8.1	2.8	-2.8	-0.6	-0.8	-0.1	0.8	1.0	-0.9	1.3	1.4	1.1