Acadl

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability Acadl 0.04 0.02 6.0e-03 0.01 0.01 0 0 9.6e-03 5.5e-02 2.6e-01 1.0e-01
2 Liver mRNA stability Acadl 0.32 0.16 1.8e-13 0.09 0.1 0.09 0.11 1.6e-10 2.4e-11 2.2e-10 8.0e-12
3 Adipose mRNA stability Acadl 0.24 0.08 0.0e+00 0.16 0.18 0.18 0.18 2.6e-17 2.4e-19 8.0e-20 1.1e-19
4 LHb gene expression Acadl 0.33 0.12 6.1e-07 0.13 0.26 0.21 0.2 5.0e-04 5.2e-07 8.6e-06 1.4e-05
5 Liver gene expression Acadl 0.08 0.05 1.6e-04 0.01 0.01 0.01 0.01 1.4e-02 7.0e-03 3.7e-02 8.4e-03
6 pVTA gene expression Acadl 0.22 0.1 2.4e-10 0.23 0.22 0.17 0.23 1.7e-10 1.1e-09 1.1e-07 3.1e-10
7 NAcc gene expression Acadl 0.14 0.06 0.0e+00 0.18 0.19 0.2 0.19 4.0e-20 3.3e-21 4.6e-22 3.1e-21
8 OFC gene expression Acadl 0.37 0.2 7.9e-04 0.04 0.09 0.15 0.05 4.6e-02 4.6e-03 1.8e-04 2.6e-02
9 Adipose gene expression Acadl 0.25 0.09 0.0e+00 0.13 0.18 0.17 0.18 1.3e-14 8.1e-20 6.9e-19 4.0e-19
10 PL gene expression Acadl 0.13 0.06 8.9e-16 0.14 0.14 0.14 0.14 3.6e-15 5.1e-15 7.5e-15 2.5e-15
11 BLA gene expression Acadl 0.17 0.07 8.8e-09 0.16 0.13 0.14 0.14 6.2e-09 1.9e-07 5.8e-08 6.9e-08
12 Brain gene expression Acadl 0.14 0.06 5.5e-12 0.08 0.12 0.12 0.13 7.0e-08 3.5e-11 2.5e-11 3.1e-12
13 IL gene expression Acadl 0.24 0.11 1.6e-04 0.15 0.12 0.12 0.17 1.6e-04 6.6e-04 8.9e-04 8.2e-05
14 Brain mRNA stability Acadl 0.08 0.04 2.5e-04 0.01 0.04 0.04 0.03 4.8e-02 1.1e-04 1.3e-04 7.8e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.21.3-0.30.0-0.40.6-0.4-1.1-0.2-0.10.1-0.00.0-0.20.0-0.5
Area under the delay curve0.20.21.41.0-0.30.70.2-0.10.10.5-0.3-0.20.1-0.10.2-0.3-1.2
BMI with tail1.96.121.34.2-4.63.8-1.63.72.91.1-0.1-0.60.6-0.60.60.7-1.9
BMI without tail0.61.36.51.9-2.51.7-0.31.40.70.3-0.0-0.20.3-0.30.20.7-1.4
Body weight0.41.74.20.6-1.0-0.11.80.2-1.5-0.4-2.10.61.5-1.51.41.6-1.7
Weight adjusted by age0.30.41.20.8-0.50.60.01.10.3-0.1-0.90.40.6-0.60.70.3-0.4
Bone surface0.61.12.0-0.40.1-0.91.40.4-1.2-1.4-1.01.41.2-1.21.21.2-0.3
Bone volume0.50.83.0-1.10.8-1.31.3-1.0-1.7-0.9-0.40.60.3-0.30.20.3-0.2
Breakpoint value in progressive ratio session0.91.02.0-0.80.8-0.2-0.9-1.00.41.10.8-1.3-1.31.3-1.4-0.81.1
Number of licking bursts0.50.61.50.7-0.70.30.61.2-0.2-0.7-0.90.71.0-1.01.10.7-0.7
Context. condit. distance diff. score0.40.51.00.3-0.90.5-0.2-0.6-0.50.81.0-0.9-0.60.6-0.7-0.8-0.9
Locomotion velocity, session 10.50.51.8-1.21.4-1.1-0.0-0.50.2-0.6-0.30.6-0.10.10.10.11.3
Locomotion distance, session 10.10.10.30.1-0.30.2-0.4-0.40.6-0.30.5-0.3-0.40.4-0.2-0.2-0.0
Locomotion velocity, session 22.52.95.40.4-0.7-0.41.81.4-0.9-2.0-2.32.02.1-2.12.32.3-0.9
Locomotion distance, session 20.10.20.50.7-0.70.6-0.40.70.6-0.60.00.10.2-0.20.30.5-0.0
Locomotion velocity, session 31.92.24.60.4-0.41.1-1.7-0.81.11.61.7-2.1-1.91.9-2.1-1.60.0
Locomotion distance, session 30.80.92.8-1.71.3-1.60.7-1.4-0.7-1.30.40.5-0.00.0-0.10.10.8
Stereotopy head waving bouts, day 33.64.210.61.8-1.12.4-3.31.83.22.70.8-2.0-1.81.8-1.6-1.91.1
Stereotopy head waving duration, day 34.04.810.42.0-1.62.7-3.21.82.53.21.1-2.4-2.02.0-2.0-2.20.5
Locomotion velocity, session 71.21.33.0-0.1-0.6-0.51.6-1.0-1.1-1.70.71.01.2-1.21.11.3-1.5
Locomotion distance, session 72.73.48.5-0.7-0.3-1.42.5-0.6-1.7-2.9-0.92.42.2-2.22.22.4-1.0
Stereotopy head waving bouts, day 70.10.10.30.5-0.50.50.00.3-0.20.30.3-0.20.0-0.0-0.00.1-0.5
Stereotopy head waving duration, day 71.61.93.51.6-1.41.8-0.8-0.20.11.81.9-1.8-1.11.1-1.2-1.0-1.8
Locomotion velocity, session 80.20.20.50.7-0.60.6-0.20.60.5-0.30.70.10.1-0.10.2-0.0-0.4
Locomotion distance, session 80.10.10.70.3-0.80.30.10.0-0.1-0.40.3-0.00.1-0.10.10.2-0.5
Degree of sensitization distance1.11.11.81.1-1.40.60.81.0-0.2-0.5-1.00.91.3-1.31.31.2-1.2
Degree of sensitization stereotypy0.50.62.70.7-0.90.41.0-0.1-0.9-0.50.50.30.7-0.70.60.8-1.6
Conditioned locomotion0.30.30.7-0.30.4-0.50.90.3-0.7-0.8-0.70.60.6-0.60.50.7-0.2
Cocaine response after cond. corrected0.30.31.3-1.10.9-0.90.1-0.4-0.3-0.70.40.4-0.20.2-0.1-0.20.8
Cocaine response after cond. not corrected0.70.82.1-1.51.2-1.40.8-1.0-1.1-1.10.10.70.2-0.20.20.30.6
Cocaine response before conditioning0.91.13.1-0.20.1-0.71.7-0.6-1.8-1.0-0.70.91.2-1.21.11.2-0.9
Saline control response0.70.94.01.1-1.20.8-0.22.01.0-0.2-0.80.70.9-0.90.90.8-0.2
Bone: connectivity density0.91.42.01.1-1.40.41.01.3-0.7-1.1-1.01.11.4-1.41.31.4-1.2
Bone: cortical apparent density1.92.58.32.3-2.01.6-0.82.91.8-0.2-1.50.91.3-1.31.51.30.0
Bone: cortical area1.42.15.4-0.70.7-1.41.60.2-1.1-2.3-1.62.01.5-1.51.71.60.2
Bone: cortical porosity2.73.010.3-3.22.9-2.81.3-2.0-2.2-0.6-0.70.3-0.40.4-0.5-0.41.4
Bone: cortical porosity3.03.311.4-3.43.1-3.01.4-1.9-2.2-0.7-1.00.4-0.30.3-0.5-0.31.7
Bone: cortical thickness1.52.56.9-0.00.1-0.91.60.5-0.8-2.6-1.52.31.9-1.92.02.0-0.3
Bone: cortical thickness0.40.51.9-1.41.2-1.00.2-0.4-0.4-0.70.10.5-0.00.0-0.00.11.1
Bone: cortical tissue density1.92.68.52.4-2.11.7-0.92.91.9-0.1-1.50.81.3-1.31.41.3-0.1
Condit. Reinf. active minus inactive responses0.80.92.7-1.21.1-1.30.31.10.1-1.1-0.91.30.5-0.50.50.41.7
Condit. Reinf. active-inactive response ratio0.20.31.2-0.60.5-0.4-0.40.60.90.1-0.20.2-0.20.2-0.3-0.41.1
Condit. Reinf. active responses1.31.63.2-1.41.3-1.71.00.8-0.5-1.6-1.11.81.1-1.11.10.81.3
Condit. Reinf. inactive responses0.91.02.1-0.80.9-1.21.10.3-0.9-1.4-0.91.31.0-1.01.20.90.5
Incentive salience index mean1.11.32.7-1.11.1-1.40.81.1-0.4-1.5-1.11.61.0-1.01.00.81.3
Condit. Reinf. lever presses0.50.71.6-0.60.9-0.90.80.4-0.6-1.3-0.81.10.9-0.90.90.70.6
Condit. Reinf. active minus inactive responses2.83.58.5-2.72.9-2.92.1-1.6-2.1-2.3-0.71.80.9-0.91.00.71.0
Condit. Reinf. active-inactive response ratio2.52.66.4-2.52.5-2.51.6-2.2-2.2-1.80.70.90.1-0.10.2-0.00.6
Condit. Reinf. active responses2.02.86.4-2.22.4-2.51.8-0.7-1.7-2.0-1.51.91.2-1.21.30.91.1
Condit. Reinf. inactive responses0.70.95.3-0.50.5-0.70.60.9-0.3-0.3-2.31.00.9-0.90.90.80.6
Condit. Reinf. lever presses0.20.31.3-0.91.2-0.7-0.2-0.30.2-0.2-0.40.2-0.20.2-0.2-0.31.1
Condit. Reinf. lever reinforcers received2.12.96.7-2.42.5-2.61.9-1.1-1.9-1.9-1.41.71.0-1.01.10.81.0
Conditioned reinforcement - actives0.20.20.40.6-0.30.60.20.5-0.0-0.4-0.60.20.4-0.40.40.3-0.6
Conditioned reinforcement - inactives0.70.83.1-0.91.8-0.91.1-1.2-1.0-1.10.20.60.7-0.70.7-0.2-0.1
Conditioned locomotion2.53.09.72.8-2.13.1-1.50.62.32.0-0.1-1.5-0.50.5-0.5-0.8-2.1
Patch foraging indifference point 0 sec1.52.56.20.9-0.70.30.62.50.7-1.4-2.41.82.1-2.12.01.40.1
Patch foraging indifference point AUC0.20.20.8-0.4-0.1-0.20.2-0.9-0.70.10.6-0.3-0.30.3-0.40.1-0.4
Delay disc. indifference point, 0s delay0.50.61.41.1-1.21.2-0.50.00.51.00.3-0.7-0.50.5-0.3-0.3-1.0
Delay disc. indifference point, 16s delay0.10.10.70.7-0.00.50.0-0.20.30.30.1-0.2-0.00.00.2-0.6-0.8
Delay disc. indifference point, 2s delay1.31.53.01.6-1.31.7-0.9-0.50.91.51.0-1.4-0.80.8-0.9-1.0-1.7
Delay disc. indifference point, 24s delay1.01.02.91.1-0.60.40.61.70.1-0.7-1.51.01.1-1.11.30.6-0.6
Delay disc. indifference point, 4s delay0.40.41.11.0-0.90.9-0.40.10.41.00.1-0.5-0.20.2-0.1-0.3-0.9
Delay disc. indifference point, 8s delay0.50.61.20.50.0-0.11.10.1-0.8-0.7-0.90.70.9-0.91.00.6-1.1
Indifference point function ln k0.71.02.31.4-0.81.5-1.31.31.51.3-0.9-0.7-0.30.3-0.2-0.40.1
Indifference point function log k0.71.02.31.4-0.81.5-1.31.31.51.3-0.9-0.7-0.30.3-0.2-0.40.1
Patch foraging total patch changes 0 sec1.21.95.70.8-0.60.40.32.40.8-1.1-2.41.51.7-1.71.71.10.3
Patch foraging total patch changes 12 sec0.00.00.1-0.0-0.10.0-0.20.20.10.1-0.20.10.0-0.00.00.10.3
Patch foraging total patch changes 18 sec0.50.61.80.5-1.00.50.11.30.3-1.30.30.80.8-0.80.71.2-0.2
Patch foraging total patch changes 24 sec0.10.10.20.0-0.10.0-0.20.30.5-0.40.20.30.3-0.30.30.20.3
Patch foraging total patch changes 6 sec0.91.33.51.2-1.60.80.51.90.2-0.8-1.00.91.4-1.41.31.2-0.8
Patch foraging time to switch 0 sec0.40.62.5-1.00.4-0.6-0.1-1.00.30.01.6-0.4-0.90.9-0.7-0.50.5
Patch foraging water rate 0 sec0.61.02.31.0-0.80.50.90.6-1.0-0.7-1.50.81.2-1.21.11.1-1.3
Patch foraging water rate 12 sec0.30.51.40.7-0.61.0-1.10.51.20.50.4-0.7-0.60.6-0.6-0.7-0.1
Patch foraging water rate 18 sec0.40.51.5-0.71.0-0.3-0.7-0.10.10.8-0.7-0.5-0.70.7-0.6-0.71.2
Patch foraging water rate 24 sec0.10.10.4-0.2-0.00.00.2-0.2-0.6-0.50.1-0.1-0.20.2-0.20.4-0.4
Patch foraging water rate 6 sec0.81.23.71.9-1.81.7-0.81.91.1-0.3-0.30.00.3-0.30.40.5-0.7
Seeking ratio, delayed vs. immediate footshock0.50.52.2-0.50.9-0.3-0.5-0.7-0.10.41.5-0.6-0.60.6-0.6-1.00.8
Distance traveled before self-admin0.30.31.4-0.40.8-0.40.1-0.9-0.31.20.0-0.5-0.40.4-0.4-0.6-0.0
Distance traveled after self-admin0.40.41.60.5-0.80.00.9-0.4-0.40.1-0.30.50.8-0.90.80.3-1.3
Extensor digitorum longus weight1.24.712.52.9-3.22.00.53.50.8-0.9-2.21.32.1-2.22.12.2-1.9
Bone: elastic displacement0.50.51.80.7-0.20.7-1.21.21.30.7-0.1-0.1-0.40.4-0.3-0.30.9
Bone: elastic work0.30.41.0-0.30.5-0.60.40.6-0.2-1.0-0.71.00.6-0.60.70.70.6
Bone: endosteal estimation0.51.13.3-1.81.7-1.60.7-1.6-1.40.1-0.4-0.3-0.50.5-0.5-0.60.7
Bone: endosteal perimeter0.30.51.4-1.11.2-0.8-0.0-0.8-0.60.30.1-0.6-0.70.7-0.7-0.70.7
Epididymis fat weight2.96.719.90.3-0.8-0.93.31.1-2.6-1.9-4.52.43.3-3.23.03.3-1.8
Delta time in closed arm before/after self-admin2.01.94.50.9-1.10.21.22.0-0.8-1.3-2.11.41.7-1.71.71.2-1.0
Delta time in open arm before/after self-admin4.03.96.7-1.22.3-0.2-1.5-2.40.92.62.4-2.2-2.22.2-2.2-2.51.0
Diff in mean of infusions in LGA sessions2.62.86.01.8-1.52.2-2.42.12.52.30.2-1.5-1.01.0-1.1-1.50.4
Delay discount exponential model param0.30.31.4-1.00.3-0.7-0.10.0-0.2-0.60.30.2-0.10.1-0.20.31.2
Extinction: sum of active levers before priming1.01.02.70.8-0.31.1-1.2-0.10.81.6-0.2-1.6-1.11.1-1.2-1.2-0.0
Active lever presses in extinction session 60.10.10.2-0.30.3-0.40.4-0.3-0.1-0.40.10.30.2-0.20.30.20.1
Bone: final force0.50.92.6-1.41.3-1.40.9-1.6-1.4-0.9-0.50.2-0.00.00.10.00.2
Bone: final moment0.40.61.9-1.21.0-1.20.8-1.4-1.2-0.9-0.40.2-0.00.00.20.00.1
Food consumed during 24 hour testing period1.92.34.5-1.01.1-0.2-1.2-1.9-0.11.51.0-1.9-2.12.1-2.1-1.90.7
Glucose0.50.81.71.3-1.10.60.60.90.0-0.4-0.50.61.2-1.21.10.8-1.0
Heart weight0.60.83.9-0.50.9-0.7-0.61.41.3-0.1-1.20.60.1-0.10.2-0.32.0
Delay discount hyperbolic model param0.30.31.6-1.10.5-0.8-0.00.0-0.2-0.70.20.3-0.00.0-0.10.41.2
Intermittent access intake day 1-15 change0.50.41.50.90.50.8-0.80.70.70.80.4-0.5-0.30.3-0.2-1.2-0.1
Intermittent access intake escalation1.11.13.30.80.60.9-1.40.71.21.40.6-1.1-0.90.9-0.8-1.80.5
Intermittent access intake escalation 21.41.43.21.00.71.0-1.70.61.31.60.4-1.4-1.31.3-1.2-1.80.5
Intermitt. access day 1 inactive lever presses0.40.41.3-1.10.7-1.00.2-0.4-0.2-0.9-0.90.50.3-0.20.30.31.0
Intermitt. access day 15 inactive lever presses0.80.92.5-0.91.4-0.5-0.6-1.0-0.41.00.9-1.1-0.80.8-0.9-1.60.9
Intermitt. access escalation Index1.51.43.60.5-0.91.0-1.80.91.61.90.1-1.2-1.01.0-1.0-1.20.8
Intermittent access day 1 total infusions0.50.61.9-0.8-0.2-0.60.7-1.0-0.8-1.31.40.60.5-0.50.50.4-0.2
Intermittent access day 15 total infusions0.20.21.10.6-0.30.6-0.20.20.4-0.21.0-0.10.2-0.30.3-0.7-0.4
Intermittent access terminal intake (last 3 days)0.60.61.80.9-0.21.0-1.10.41.10.71.0-0.8-0.50.5-0.4-1.40.0
Intermittent access total infusions0.20.31.8-0.0-0.00.00.2-0.7-0.1-0.61.30.20.3-0.30.4-0.5-0.4
Intermittent access day 1 locomotion0.50.52.0-0.5-0.0-0.40.7-1.0-0.2-1.40.80.80.6-0.60.70.7-0.2
Intermittent access day 15 total locomotion0.20.31.00.5-0.20.7-0.4-0.50.7-0.31.0-0.5-0.30.3-0.3-0.3-0.4
Intermittent access total locomotion0.30.41.20.9-0.51.1-0.4-0.20.9-0.21.0-0.30.0-0.00.1-0.2-0.8
Intermittent access standard deviation1.21.32.60.01.30.3-1.2-1.11.41.21.4-1.3-1.11.1-1.1-1.60.8
Left kidney weight0.10.32.10.2-0.4-0.00.40.6-0.30.2-1.4-0.10.3-0.30.20.7-0.3
Right kidney weight0.61.75.2-0.2-0.1-0.91.70.7-1.8-1.3-2.31.21.3-1.31.31.7-0.4
Cocaine induced anxiety0.70.91.9-0.30.00.3-1.1-0.70.71.10.7-1.4-1.31.3-1.3-0.70.7
Post-drug Anxiety0.50.51.10.6-0.91.0-0.80.30.21.00.6-1.0-0.60.6-0.8-0.4-0.4
Baseline Anxiety0.60.71.90.7-0.40.30.71.4-0.8-0.5-0.71.01.1-1.11.10.3-0.8
Tail length3.29.528.3-3.93.3-4.54.4-3.2-5.3-3.0-2.02.31.6-1.61.42.00.0
Length with tail3.011.032.3-4.14.2-4.84.6-3.7-5.7-2.2-3.11.91.7-1.71.41.60.1
Length without tail1.12.36.9-1.01.5-1.62.1-0.5-2.2-0.9-2.61.11.6-1.61.51.2-0.1
Times rat made contact with spout0.91.12.5-1.51.4-1.0-0.8-1.20.10.50.1-0.6-1.21.2-1.1-1.11.6
Lifetime Intake0.20.31.10.3-0.30.10.3-0.5-0.3-0.51.00.30.5-0.50.6-0.3-0.8
Liver weight, left0.71.14.3-2.11.7-1.70.3-1.1-0.8-0.1-0.70.0-0.40.4-0.5-0.41.4
Liver weight, right0.61.03.8-1.41.5-1.3-0.4-0.50.60.4-1.6-0.2-0.50.5-0.4-0.32.0
Locomotor activity0.30.41.40.4-0.10.4-0.41.21.00.8-0.70.30.5-0.60.6-0.50.5
Locomotor testing distance0.10.21.00.20.20.2-0.41.00.40.5-0.30.40.4-0.40.4-0.60.6
Locomotor testing rearing0.10.20.60.00.1-0.1-0.30.80.30.5-0.70.30.4-0.40.3-0.20.7
Locomotion in novel chamber1.01.22.41.3-0.91.5-1.51.01.51.40.7-1.1-0.80.8-0.8-0.80.2
Locomotion in novel chamber post-restriction0.60.71.30.6-0.20.30.80.9-0.3-1.0-1.11.11.1-1.11.21.0-0.5
Fecal boli incidents, locomotor time 10.50.61.9-1.31.2-1.10.6-1.0-1.4-0.2-0.5-0.1-0.10.1-0.3-0.10.5
Change in fecal boli incidents, locomotor task0.20.10.90.20.50.2-0.4-0.00.90.20.60.1-0.10.1-0.1-0.40.4
Time >=10cm from walls, locomotor time 11.01.13.3-1.71.6-1.50.0-0.90.2-1.40.30.7-0.30.30.00.21.8
Bouts of movement, locomotor time 10.60.63.4-1.11.3-1.0-0.10.50.1-0.7-0.10.70.1-0.10.20.21.8
Total resting periods, locomotor time 10.70.73.7-1.11.1-1.1-0.10.50.1-1.10.00.90.2-0.20.40.51.9
Rest time, locomotor task time 10.50.63.1-0.81.4-0.8-0.30.60.2-0.2-0.70.4-0.00.00.2-0.01.8
Distance moved, locomotor task time 11.21.33.80.5-1.2-0.01.6-0.6-1.1-1.3-0.60.91.1-1.11.11.5-2.0
Vertical activity count, locomotor time 10.30.31.60.4-1.20.30.5-0.3-0.3-0.20.10.20.2-0.20.30.5-1.1
Time >=10cm from walls, locomotor time 20.80.91.3-0.81.1-0.3-0.8-1.10.60.91.1-0.8-1.11.1-1.1-1.10.9
Bouts of movement, locomotor time 20.70.82.81.0-0.70.50.11.70.6-0.5-0.90.91.0-1.01.20.7-0.0
Total resting periods, locomotor time 20.50.52.10.5-0.20.2-0.01.40.5-0.5-0.90.80.8-0.81.00.50.5
Rest time, locomotor task time 21.11.34.4-1.11.6-1.40.30.9-0.4-1.1-1.61.10.6-0.60.70.32.1
Distance moved, locomotor task time 20.50.63.60.9-1.20.70.7-0.6-0.1-0.1-0.2-0.00.6-0.60.20.7-1.9
Vertical activity count, locomotor time 21.41.54.11.7-2.01.9-1.10.51.31.70.4-1.3-0.50.5-0.8-0.4-1.3
Light reinforcement 11.01.93.81.8-1.61.9-1.71.41.11.90.3-1.5-1.11.1-1.2-0.8-0.3
Light reinforcement 20.60.91.7-0.50.5-0.2-0.4-1.2-0.21.00.9-1.2-1.31.3-1.3-1.20.2
Bone: marrow area0.51.13.2-1.81.7-1.60.8-1.5-1.5-0.1-0.5-0.1-0.30.3-0.3-0.40.7
Bone: maximum diameter0.61.12.6-1.31.4-1.61.0-0.1-0.7-1.3-1.61.10.7-0.70.80.71.0
Bone: maximum force0.30.62.8-0.90.8-0.70.4-1.7-1.1-0.30.5-0.4-0.60.6-0.5-0.6-0.1
Bone: maximum moment0.20.42.1-0.60.5-0.40.2-1.4-0.8-0.20.7-0.5-0.60.6-0.5-0.6-0.2
Mean time between licks in bursts0.30.42.30.8-0.50.7-0.51.20.60.1-1.5-0.10.3-0.30.20.40.3
Mean num. licks in bursts1.01.22.1-1.21.3-0.7-0.9-1.50.30.70.8-0.8-1.31.3-1.4-1.01.4
Cd content in liver1.51.63.20.2-0.10.8-1.2-0.81.01.81.5-1.7-1.61.6-1.6-1.6-0.0
Co content in liver0.20.21.00.4-0.40.40.2-0.70.10.01.0-0.20.0-0.0-0.0-0.1-0.9
Cu content in liver1.82.24.40.2-0.2-0.52.00.5-1.3-1.6-1.31.72.1-2.12.02.0-1.0
Fe content in liver0.30.31.1-0.90.8-0.8-0.2-0.1-0.50.3-0.6-0.1-0.40.4-0.4-0.31.0
K content in liver0.60.61.00.9-0.90.50.50.9-0.2-0.4-0.60.61.0-1.01.00.8-0.8
Mg content in liver0.40.41.11.0-1.00.8-0.01.00.2-0.0-0.30.20.5-0.50.50.4-0.7
Mn content in liver1.31.55.91.7-1.41.7-1.52.41.71.0-0.7-0.4-0.20.2-0.2-0.20.1
Na content in liver0.30.30.9-0.60.4-0.80.8-0.1-1.0-0.6-0.50.70.5-0.50.50.30.1
Rb content in liver0.81.02.20.3-0.1-0.10.60.80.6-1.0-1.31.31.3-1.31.51.3-0.0
Se content in liver0.30.32.40.6-0.60.5-0.10.80.10.7-1.5-0.30.2-0.30.10.2-0.2
Sr content in liver1.21.13.9-0.50.7-0.7-0.32.00.5-0.6-1.71.00.7-0.70.80.71.9
Zn content in liver0.30.41.30.8-0.80.60.60.0-0.1-0.1-0.50.10.7-0.70.60.7-1.1
Bone: minimum diameter1.01.94.0-1.71.5-2.01.7-0.7-1.9-1.8-1.51.30.9-0.90.90.80.6
Time in familiar zone, hab. session 13.02.86.11.6-1.32.1-1.80.02.02.51.8-1.9-1.41.4-1.4-1.6-0.8
Time in novel zone, hab. session 12.82.87.8-2.82.7-2.71.0-0.7-1.9-1.8-0.81.20.2-0.20.30.52.3
Total zone transitions, hab. session 11.52.26.5-0.80.3-1.32.10.0-1.5-2.6-0.32.01.6-1.61.71.6-0.6
Total locomotion distance, hab. session 11.01.44.4-1.31.0-1.61.4-0.1-1.0-2.1-0.01.61.0-1.01.10.80.5
Locomotion velocity, hab. session 11.52.15.6-1.10.8-1.61.90.2-1.4-2.4-0.82.01.6-1.61.61.20.1
Time in familiar zone, hab. session 21.61.66.50.3-0.60.8-1.0-1.20.31.42.6-1.6-1.41.4-1.5-1.2-0.6
Time in novel zone, hab. session 21.11.14.9-0.20.5-0.50.41.5-0.2-0.9-2.21.21.0-1.01.10.80.9
Total zone transitions, hab. session 20.10.10.3-0.20.0-0.0-0.30.00.50.1-0.3-0.3-0.30.3-0.3-0.10.3
Total locomotion distance, hab. session 20.10.10.4-0.00.0-0.1-0.20.60.6-0.5-0.30.10.1-0.10.10.00.4
Locomotion velocity, hab. session 20.10.10.3-0.0-0.0-0.1-0.00.50.5-0.6-0.30.10.2-0.20.20.10.3
Novel to familiar place preference ratio0.80.82.6-0.90.9-1.11.6-0.8-1.6-0.5-0.10.80.8-0.80.60.5-0.5
Novelty place preference0.60.62.1-0.91.0-1.11.3-0.7-1.5-0.20.00.50.5-0.50.40.3-0.3
Time in novel zone, NPP test0.60.62.4-1.11.2-1.11.2-0.8-1.6-0.10.20.40.3-0.30.10.1-0.1
Total zone transitions, NPP test0.00.00.1-0.20.0-0.1-0.00.10.1-0.1-0.3-0.0-0.10.1-0.10.10.2
Total locomotion distance, NPP test0.10.20.9-0.40.4-0.50.30.40.0-0.9-0.00.60.4-0.40.40.20.5
Locomotion velocity, NPP test0.10.20.7-0.00.1-0.20.20.60.4-0.8-0.30.60.5-0.50.50.30.3
Intraocular pressure0.81.22.61.1-1.11.5-1.3-0.11.61.61.0-1.2-0.90.9-0.8-0.4-0.4
Delta distance traveled before/after self-admin0.50.51.51.0-1.20.70.21.00.2-0.3-0.40.50.8-0.80.80.5-0.8
Delta ambulatory time before/after self-admin0.70.81.40.5-1.10.10.70.6-0.3-1.2-0.71.01.1-1.11.11.2-0.7
Parametrial fat weight1.42.76.6-1.50.3-1.92.4-1.1-2.6-2.2-1.11.31.3-1.31.12.3-0.4
Pavlov. Cond. lever latency3.84.88.4-0.30.30.8-2.7-1.12.02.92.4-2.7-2.82.8-2.8-2.51.4
Pavlov. Cond. magazine entry latency0.91.23.4-0.70.5-1.21.8-0.9-1.5-1.2-0.61.21.1-1.11.01.0-0.9
Pavlov. Cond. change in total contacts2.42.65.30.5-0.7-0.42.30.3-1.5-1.9-0.21.92.1-2.12.11.8-1.9
Pavlov. Cond. index score1.92.45.3-0.40.3-1.22.3-0.0-1.8-2.0-1.22.01.9-1.91.91.7-1.0
Pavlov. Cond. latency score1.82.34.9-0.40.2-1.12.2-0.0-1.8-2.0-1.21.91.8-1.81.81.6-0.9
Pavlov. Cond. lever contacts1.92.23.90.2-0.1-0.61.71.1-1.0-1.8-1.82.01.9-1.92.01.7-0.6
Pavlov. Cond. magazine entry number1.51.84.40.7-0.41.3-2.10.41.51.60.9-1.8-1.51.5-1.5-1.40.8
Pavlov. Cond. intertrial magazine entries0.50.63.20.10.10.1-0.71.80.9-0.7-1.10.40.2-0.20.30.31.4
Pavlov. Cond. lever-magazine prob. diff.1.41.83.8-0.30.3-1.02.0-0.1-1.4-1.8-1.01.71.6-1.61.61.4-0.8
Pavlov. Cond. response bias1.92.34.1-0.60.6-1.32.00.2-1.4-1.9-1.72.01.8-1.81.81.7-0.4
Pavlov. Cond. lever latency0.60.82.41.2-1.50.80.70.9-0.50.1-0.50.30.9-0.90.80.9-1.5
Pavlov. Cond. magazine entry latency1.51.73.2-0.70.90.1-1.4-1.31.00.91.6-1.4-1.71.7-1.8-1.61.0
Pavlov. Cond. change in total contacts0.50.62.4-1.31.6-0.9-0.3-0.70.2-0.70.50.1-0.50.5-0.4-0.41.4
Pavlov. Cond. index score1.21.63.8-1.51.9-0.8-1.2-1.10.90.20.7-0.7-1.41.4-1.4-1.32.0
Pavlov. Cond. latency score1.11.43.0-1.41.7-0.7-1.0-1.20.60.10.9-0.7-1.31.3-1.3-1.21.6
Pavlov. Cond. lever contacts0.81.13.9-1.72.0-1.2-0.5-1.00.2-0.20.2-0.2-0.90.9-0.8-0.91.8
Pavlov. Cond. magazine entry number1.41.73.11.1-1.30.21.60.9-1.0-0.9-0.81.21.7-1.71.71.5-1.7
Pavlov. Cond. intertrial magazine entries3.44.47.41.4-2.00.22.51.6-1.7-1.5-1.92.02.7-2.72.62.5-2.5
Pavlov. Cond. lever-magazine prob. diff.1.51.94.1-1.41.8-0.6-1.5-1.11.10.50.9-0.9-1.61.6-1.6-1.52.0
Pavlov. Cond. response bias1.11.64.5-1.72.0-1.0-1.0-1.00.80.20.3-0.5-1.31.3-1.1-1.22.1
Time in closed arm before self-admin1.11.34.0-2.01.3-1.4-0.1-1.9-0.3-0.41.0-0.5-1.01.0-1.00.11.4
Time in closed arm after self-admin1.81.96.1-0.8-0.0-1.31.70.1-1.5-2.5-1.31.61.2-1.21.22.0-0.1
Time in open arm before self-admin2.93.111.72.3-2.11.50.23.40.8-0.6-2.31.61.8-1.81.90.7-0.9
Time in open arm after self-admin1.11.24.2-0.31.00.2-1.1-0.50.92.00.8-1.1-1.11.1-1.1-1.90.8
Bone: periosteal estimation0.91.94.3-1.81.7-2.11.6-0.9-1.8-1.5-1.61.20.7-0.70.80.80.7
Bone: periosteal perimeter0.40.72.7-1.41.6-1.30.2-0.7-0.6-0.3-0.80.0-0.40.4-0.3-0.31.3
Bone: post-yield work1.11.43.1-0.1-0.00.5-0.8-1.80.11.01.8-1.7-1.51.5-1.4-1.6-0.6
Progressive ratio test 1 active lever presses0.20.20.70.3-0.10.20.4-0.00.2-0.30.20.60.8-0.80.80.0-0.3
Progressive ratio test 1 breakpoint0.10.20.50.20.10.20.4-0.10.2-0.20.10.50.7-0.70.7-0.1-0.2
Progressive ratio test 1 inactive lever presses0.30.30.90.7-0.10.8-0.70.30.80.9-0.6-0.50.0-0.00.0-0.60.2
Progressive ratio test 2 active lever presses0.30.31.00.1-0.1-0.10.6-0.00.0-1.00.50.70.8-0.90.9-0.0-0.5
Progressive ratio test 2 breakpoint0.30.31.00.10.1-0.10.50.10.2-1.00.30.70.9-0.90.9-0.0-0.2
Progressive ratio test 2 inactive lever presses0.10.10.6-0.20.3-0.0-0.2-0.5-0.0-0.60.8-0.10.0-0.00.1-0.50.2
Incentive Sensitization - Responses0.20.21.0-0.00.3-0.20.3-0.20.1-1.00.60.40.4-0.40.5-0.0-0.2
Incentive Sensitization - Breakpoint0.20.21.0-0.10.3-0.30.4-0.20.1-1.00.40.40.4-0.40.50.1-0.1
Sum of active levers in priming session hrs 5-60.80.81.9-0.0-0.1-0.51.3-0.3-1.4-1.1-1.00.81.0-1.01.00.8-0.8
Progressive ratio0.70.82.4-0.3-0.2-0.70.70.4-0.0-1.5-0.31.30.9-0.91.01.50.7
Food seeking constrained by brief footshock1.11.34.41.8-2.11.9-0.51.40.91.1-0.2-0.60.1-0.1-0.00.1-1.6
Seeking ratio, punishment vs. effort1.01.33.91.1-1.11.5-0.70.00.32.00.4-1.5-0.80.8-0.9-1.2-1.7
Retroperitoneal fat weight0.41.34.71.1-1.90.71.2-0.3-0.70.0-0.80.11.2-1.21.01.1-2.2
Reaction time number correct0.60.93.61.0-0.71.1-1.51.91.50.50.5-0.4-0.50.5-0.3-0.50.6
Reaction time mean minus median0.30.41.0-0.40.0-0.2-0.6-0.4-0.00.5-0.2-0.8-1.01.0-0.9-0.40.7
Reaction time mean minus median AUC0.50.61.6-0.50.3-0.2-0.9-0.50.20.60.1-0.9-1.21.3-1.1-0.70.9
Reaction time num false alarms0.91.34.42.1-2.01.8-0.41.60.8-0.0-0.3-0.30.5-0.50.50.6-1.2
Reaction time num false alarms AUC0.81.13.41.8-1.71.5-0.21.60.5-0.2-0.4-0.00.7-0.70.70.8-1.1
Reaction time trials correct on left0.60.93.61.0-0.71.1-1.51.91.50.50.5-0.4-0.50.5-0.3-0.50.6
Reaction time trials on left0.60.93.50.9-0.71.1-1.41.91.50.40.5-0.4-0.50.5-0.3-0.40.6
Reaction time mean1.52.16.6-2.52.6-2.40.8-2.1-1.0-0.6-1.10.4-0.30.3-0.20.01.5
Reaction time mean AUC1.41.95.3-2.32.2-2.31.2-2.0-1.3-0.9-1.00.7-0.00.00.10.31.1
Median of all reaction times2.33.19.6-2.83.1-2.91.6-2.3-1.4-1.3-1.51.20.4-0.40.50.51.5
Reaction time omissions0.30.41.1-0.7-0.2-0.81.0-0.3-1.1-0.9-0.40.30.4-0.40.30.9-0.2
Reaction time false alarm rate0.50.72.21.1-1.20.70.80.3-0.5-0.6-0.40.20.9-0.90.81.1-1.5
Reaction time premature initiation rate0.40.51.7-0.40.9-0.3-0.80.21.00.7-0.9-0.3-0.60.6-0.5-0.51.3
Reaction time premature initiations0.91.33.90.20.50.5-1.81.22.01.2-0.6-0.7-1.11.1-0.9-0.91.6
Std. dev. reaction times0.71.02.7-1.61.1-1.3-0.0-1.6-0.90.1-0.3-0.6-1.01.0-1.0-0.31.0
Reaction time trials completed0.60.93.50.9-0.71.1-1.41.91.50.40.5-0.4-0.50.5-0.3-0.40.6
Reaction time trials AUC0.50.83.00.8-0.51.0-1.41.71.40.50.4-0.4-0.50.5-0.3-0.50.7
Run reversals in cocaine runway, females0.80.81.80.4-1.2-0.01.0-0.1-0.3-1.40.60.90.9-0.91.01.0-1.3
Run reversals in cocaine runway, males0.10.10.50.10.4-0.10.5-0.3-0.7-0.2-0.30.10.3-0.30.20.2-0.4
Latency to leave start box in cocaine runway2.02.26.91.8-1.30.90.32.30.6-0.4-2.61.31.6-1.61.81.2-0.5
Latency to leave start box in cocaine runway, F1.41.54.61.7-1.60.90.21.90.5-0.2-2.20.91.2-1.21.31.1-0.6
Latency to leave start box in cocaine runway, M0.20.20.50.00.5-0.1-0.00.60.4-0.2-0.70.70.5-0.50.70.00.5
Std. dev. time between licks in bursts1.41.77.12.1-2.11.8-0.62.70.5-0.0-1.10.30.7-0.70.60.8-0.7
Total sessions with >9 infusions0.40.41.3-0.10.4-0.50.70.20.1-0.7-0.51.10.9-0.91.00.40.1
Short access day 1 total inactive lever presses0.30.41.60.20.00.30.3-1.20.10.51.3-0.20.3-0.30.3-0.7-1.0
Short access day 10 total inactive lever presses0.70.82.3-1.41.4-0.9-0.3-1.5-0.00.40.0-0.7-0.70.7-0.8-0.71.1
Short access day 1 total infusions0.50.51.71.3-0.61.0-0.40.10.40.51.2-0.40.1-0.10.1-0.7-1.0
Short access day 10 total infusions0.10.10.5-0.50.4-0.20.2-0.7-0.20.10.30.10.1-0.10.1-0.7-0.0
Short access total infusions0.30.31.11.0-0.70.7-0.10.20.20.20.60.10.5-0.50.5-0.3-0.8
Short access day 1 locomotion1.11.12.4-0.51.0-0.91.30.1-0.4-1.3-1.41.51.3-1.31.30.90.4
Short access day 10 total locomotion0.70.81.7-0.81.3-0.1-0.8-1.11.10.50.4-0.8-1.01.1-1.0-0.71.1
Short access total locomotion0.10.10.80.20.30.20.0-0.30.9-0.3-0.20.30.2-0.20.30.0-0.0
One hour access (0.3 mA shock)0.40.52.1-0.60.9-0.3-0.3-1.50.4-0.71.0-0.4-0.50.5-0.5-0.40.5
Compulsive drug intake0.30.30.8-0.90.1-0.80.3-0.70.1-0.9-0.20.4-0.00.00.00.80.7
One hour access (shock baseline)0.20.20.5-0.20.7-0.1-0.1-0.7-0.3-0.30.7-0.4-0.20.2-0.3-0.7-0.0
Social response proportion0.20.20.70.0-0.3-0.00.60.4-0.40.3-0.80.20.5-0.50.40.5-0.4
Social responses0.10.20.5-0.60.4-0.50.40.1-0.20.1-0.70.20.3-0.30.00.60.3
Social time0.20.31.1-0.21.0-0.1-0.70.30.20.6-0.2-0.5-0.50.5-0.6-0.50.9
Soleus weight0.00.10.40.2-0.40.4-0.50.6-0.10.1-0.1-0.5-0.40.4-0.5-0.40.0
Bone: stiffness0.40.62.8-0.80.6-0.50.1-1.7-0.90.50.5-0.9-0.80.8-0.8-0.8-0.2
Tibialis anterior weight0.20.72.51.6-1.51.3-0.00.60.50.10.1-0.30.2-0.20.20.3-1.5
Time to tail flick, vehicle, before self-admin0.10.11.0-0.30.1-0.3-0.10.10.0-1.0-0.00.2-0.20.2-0.10.40.5
Time to tail flick, vehicle, after self-admin0.40.41.2-1.00.8-0.8-0.2-0.5-0.4-0.60.8-0.1-0.60.6-0.5-0.21.1
Time to tail flick, test, before self-admin1.31.34.3-1.2-0.2-1.31.4-1.0-1.4-2.10.70.90.5-0.50.51.8-0.2
Time to tail flick, test, after self-admin2.52.56.22.2-1.82.5-1.91.02.52.00.1-1.5-0.90.9-0.9-1.1-0.8
Delta time to tail flick, vehicle, before/after SA1.01.02.60.2-0.20.6-0.9-0.80.61.61.5-1.3-1.01.0-1.0-1.3-0.2
Delta time to tail flick, test, before/after SA4.54.110.42.5-1.02.8-2.71.73.23.2-0.6-1.8-1.21.2-1.1-2.10.0
Tibia length1.13.06.8-2.11.9-2.62.3-1.8-2.6-1.2-2.11.31.0-1.00.91.20.3
Ambulatory time before self-admin0.30.31.10.10.20.1-0.1-0.80.11.00.4-0.8-0.50.5-0.6-0.6-0.5
Ambulatory time after self-admin1.01.12.81.3-1.70.60.80.5-0.2-0.0-1.20.61.2-1.21.20.9-1.6
Bone: tissue strength0.40.42.20.8-0.70.40.6-0.6-0.9-0.2-0.0-0.20.2-0.20.00.1-1.5
Total heroin consumption0.80.91.9-0.91.1-0.4-0.7-1.20.10.70.5-1.3-1.21.2-1.4-0.61.0
Bone: trabecular number0.10.21.10.6-0.90.40.40.1-0.6-0.10.1-0.10.2-0.20.00.2-1.1
Bone: trabecular spacing0.71.01.8-1.01.0-1.11.0-0.7-0.5-1.3-1.11.20.9-0.91.01.00.4
Bone: trabecular thickness0.91.12.8-0.40.4-0.1-0.3-1.5-0.80.61.7-1.2-1.31.3-1.5-1.3-0.3
Bone: trabecular tissue density0.60.94.2-1.01.4-0.8-1.0-0.51.40.5-0.60.0-0.40.4-0.2-0.42.1
Water consumed over 24 hours0.20.30.90.1-0.20.4-0.90.40.70.30.1-0.5-0.70.7-0.5-0.60.5
Number of responses in last shaping day3.53.68.4-0.70.6-1.72.60.2-2.1-2.9-1.62.42.2-2.22.12.2-0.4