Hub : Genes

Abce1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Abce1	0.13	0.06	3.2e-04	0.02	0.05	0.04	0.01	1.8e-02	1.1e-04	5.2e-04	2.3e-02
2	IC	intron excision ratio	chr19_45131082_45132488	0.17	0.09	8.6e-04	0.04	0.05	0.08	0.06	1.0e-02	3.1e-03	3.1e-04	1.4e-03
3	IC	intron excision ratio	chr19_45130856_45130960	0.16	0.09	1.4e-03	0.05	0.04	0.07	0.06	4.5e-03	1.2e-02	4.5e-04	1.2e-03
4	PL	gene expression	Abce1	0.1	0.07	8.9e-04	0.03	0.03	0.03	0.03	1.3e-04	2.1e-04	5.4e-04	4.3e-04
5	PL	mRNA stability	Abce1	0.05	0.03	1.6e-03	0.03	0.03	0.03	0.03	2.5e-04	8.7e-04	3.1e-04	4.1e-04
6	BLA	gene expression	Abce1	0.21	0.09	1.4e-06	0.13	0.11	0.11	0.12	2.6e-07	1.2e-06	2.5e-06	5.4e-07
7	Brain	gene expression	Abce1	0.03	0.02	6.0e-03	0.03	0.02	0.01	0.01	2.1e-03	9.7e-03	6.7e-02	2.0e-02
8	Brain	mRNA stability	Abce1	0.12	0.07	7.1e-07	0.08	0.07	0.07	0.08	1.2e-07	9.3e-07	5.0e-07	1.2e-07
9	Adipose	gene expression	Abce1	0.06	0.03	1.2e-05	0.02	0.04	0.04	0.03	9.7e-04	2.1e-05	8.5e-05	1.8e-04
10	Adipose	mRNA stability	Abce1	0.13	0.07	9.9e-08	0.06	0.06	0.07	0.07	8.2e-07	8.8e-07	7.1e-08	3.1e-08
11	BLA	mRNA stability	Abce1	0.08	0.05	6.5e-03	0.01	0.03	0	0.02	7.4e-02	7.7e-03	2.3e-01	3.9e-02
12	NAcc	gene expression	Abce1	0.04	0.02	1.8e-05	0.02	0.02	0.02	0.02	9.8e-04	2.3e-04	7.7e-04	1.5e-03
13	NAcc	mRNA stability	Abce1	0.06	0.03	1.5e-07	0.05	0.05	0.04	0.04	4.0e-08	1.1e-07	5.9e-07	1.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	0.3	0.6	1.9	-1.4	1.0	-1.1	0.5	0.4	-1.1	0.1	-0.2	-0.9	-0.5	0.8	-0.9	0.2
Area under the delay curve	0.2	0.4	1.1	-0.7	-0.0	0.2	-0.5	-0.6	-0.8	-1.0	0.8	0.6	0.5	0.3	0.6	-0.3
BMI with tail	1.4	4.9	9.9	1.1	-3.1	3.0	-2.9	-2.1	0.9	-2.4	2.1	2.4	1.6	0.6	3.1	-1.5
BMI without tail	0.4	2.0	5.0	-2.2	-1.3	1.1	-1.9	-1.4	-1.4	-1.3	1.1	0.5	0.9	2.1	0.9	-0.7
Body weight	0.4	1.9	7.4	-2.7	1.4	-1.5	-1.3	-0.9	-2.2	-0.6	0.7	0.3	0.9	1.8	0.4	-0.4
Weight adjusted by age	0.2	0.5	1.8	1.4	0.5	-0.4	-0.2	-0.3	0.3	-0.9	0.7	0.7	1.2	-0.1	0.7	-0.1
Bone surface	0.3	0.6	1.5	-0.9	1.0	-1.1	0.2	0.3	-1.2	0.1	-0.3	-0.9	-0.5	0.9	-0.8	0.2
Bone volume	0.6	1.3	3.9	-1.5	1.8	-2.0	0.3	0.4	-1.8	-0.0	-0.2	-0.9	-0.5	1.1	-1.0	0.0
Breakpoint value in progressive ratio session	1.5	2.7	5.0	0.6	-0.9	1.1	1.4	1.7	1.6	2.1	-2.2	-1.8	-2.2	-1.5	-1.4	2.2
Number of licking bursts	0.2	0.6	1.6	-1.2	0.5	-0.5	-0.6	-0.8	-1.2	-0.5	0.7	0.4	0.6	1.1	0.3	-1.0
Context. condit. distance diff. score	0.5	0.6	1.6	0.9	1.3	-1.2	0.9	0.8	0.0	-0.5	0.6	0.5	0.5	-0.4	0.2	-0.6
Locomotion velocity, session 1	0.3	0.4	1.5	1.2	0.3	-0.5	0.9	0.9	-0.2	0.7	-0.6	-0.4	-0.5	-0.3	-0.2	0.3
Locomotion distance, session 1	0.3	0.4	1.5	1.2	-0.2	0.1	0.4	0.5	-0.2	0.8	-0.8	-0.6	-0.7	-0.2	-0.2	0.8
Locomotion velocity, session 2	0.2	0.2	0.9	0.1	0.2	-0.4	-0.6	-0.5	-0.9	-0.1	0.0	-0.2	0.1	0.8	0.1	0.0
Locomotion distance, session 2	0.2	0.3	0.8	0.4	0.1	-0.2	0.2	0.4	-0.5	0.5	-0.6	-0.8	-0.9	-0.2	-0.5	0.7
Locomotion velocity, session 3	0.1	0.2	0.5	0.4	0.4	-0.6	-0.4	-0.1	-0.3	0.1	0.2	0.3	0.7	0.5	0.1	-0.5
Locomotion distance, session 3	0.7	0.8	3.3	-0.5	-0.4	0.1	-1.6	-1.3	-1.2	-0.1	0.3	0.1	0.6	1.8	0.3	-0.5
Stereotopy head waving bouts, day 3	1.1	1.3	2.3	-0.2	-0.6	0.5	-1.4	-1.4	-0.4	-1.5	1.5	1.2	1.5	1.1	1.2	-1.3
Stereotopy head waving duration, day 3	1.3	1.6	2.9	0.8	-0.4	0.3	-1.5	-1.2	0.0	-1.6	1.7	1.7	1.7	0.6	1.5	-1.7
Locomotion velocity, session 7	0.1	0.1	0.5	-0.0	0.0	-0.1	-0.1	-0.5	-0.5	-0.1	0.1	-0.1	0.4	0.7	-0.0	0.2
Locomotion distance, session 7	0.1	0.2	0.5	-0.0	0.2	-0.2	0.7	0.4	-0.5	0.1	-0.3	-0.7	-0.4	0.1	-0.5	0.6
Stereotopy head waving bouts, day 7	1.5	1.7	5.8	-2.0	-2.4	2.4	-1.3	-1.3	-0.4	0.6	-0.3	-0.5	0.0	1.6	0.0	0.3
Stereotopy head waving duration, day 7	1.0	1.2	3.5	-1.6	-1.9	1.7	-1.4	-1.2	-0.7	0.2	0.0	-0.2	0.3	1.6	0.1	-0.1
Locomotion velocity, session 8	0.9	1.1	2.3	1.4	0.8	-0.6	1.5	1.5	0.8	0.9	-0.8	-0.5	-0.9	-1.5	-0.6	0.8
Locomotion distance, session 8	0.3	0.5	2.4	1.5	0.6	-0.7	1.0	1.1	-0.0	-0.3	0.1	-0.1	-0.2	-0.7	-0.1	0.0
Degree of sensitization distance	0.8	0.8	3.2	0.6	1.0	-0.7	1.8	1.2	0.4	-0.2	-0.2	-0.4	-0.6	-1.5	-0.7	0.8
Degree of sensitization stereotypy	1.1	1.2	3.4	-1.8	-1.8	1.8	-0.8	-0.8	-0.5	1.0	-0.7	-0.8	-0.4	1.4	-0.4	0.5
Conditioned locomotion	0.4	0.5	2.4	-0.2	1.6	-1.4	0.7	0.7	-0.3	0.1	0.0	-0.0	-0.1	-0.8	-0.6	-0.3
Cocaine response after cond. corrected	1.0	1.5	5.1	1.3	2.2	-2.3	1.7	1.5	-0.6	-0.7	0.4	-0.1	-0.0	-0.6	-0.5	-0.2
Cocaine response after cond. not corrected	0.9	1.3	4.6	1.5	2.0	-2.1	1.6	1.6	-0.6	-0.1	-0.0	-0.1	-0.1	-0.7	-0.4	-0.3
Cocaine response before conditioning	0.4	0.5	1.6	-0.2	-1.3	1.2	-0.8	-0.5	0.3	1.3	-0.9	-0.2	-0.3	0.2	0.2	0.2
Saline control response	0.9	1.2	5.0	-0.1	1.5	-1.9	0.8	0.9	-2.2	0.8	-0.6	-1.0	-0.3	0.5	-1.1	0.0
Bone: connectivity density	0.1	0.1	0.5	-0.5	-0.2	0.1	-0.2	-0.3	-0.5	-0.2	0.0	-0.5	-0.2	0.7	-0.4	0.0
Bone: cortical apparent density	0.2	0.3	0.8	-0.0	-0.9	0.9	-0.7	-0.9	0.3	-0.7	0.5	0.4	0.3	0.3	0.6	-0.1
Bone: cortical area	0.8	1.3	4.5	0.4	2.1	-2.1	1.4	1.4	-0.1	0.6	-0.7	-0.6	-0.9	-1.0	-1.0	0.5
Bone: cortical porosity	0.5	0.5	2.0	0.3	0.8	-0.9	0.3	0.9	-0.1	1.4	-1.0	-0.6	-0.6	-0.4	-0.7	0.3
Bone: cortical porosity	0.9	1.0	3.0	-0.4	1.2	-1.2	0.5	1.1	-0.2	1.7	-1.3	-0.9	-0.8	-0.4	-1.2	0.6
Bone: cortical thickness	0.3	0.5	2.1	0.6	0.5	-0.3	0.4	0.4	1.3	0.6	-0.5	0.1	-0.6	-1.5	-0.0	0.4
Bone: cortical thickness	0.1	0.1	0.3	0.3	-0.5	0.4	0.1	-0.4	0.5	0.2	-0.3	0.0	-0.4	-0.4	0.3	0.3
Bone: cortical tissue density	0.2	0.3	0.8	-0.2	-0.8	0.8	-0.7	-0.9	0.1	-0.7	0.5	0.3	0.3	0.5	0.5	-0.1
Condit. Reinf. active minus inactive responses	0.7	0.8	2.3	-1.3	-0.1	0.3	0.5	0.6	0.5	1.5	-1.3	-1.0	-0.8	-0.3	-1.0	1.0
Condit. Reinf. active-inactive response ratio	0.8	0.8	1.5	-0.2	0.2	-0.0	1.1	1.2	0.6	1.1	-1.1	-1.0	-0.9	-1.0	-1.0	1.0
Condit. Reinf. active responses	0.6	0.8	3.9	-2.0	0.0	0.1	-0.0	0.1	-0.4	1.3	-1.1	-1.0	-0.6	0.6	-0.9	0.8
Condit. Reinf. inactive responses	0.6	0.8	4.5	-2.1	0.1	-0.1	-0.3	-0.4	-1.0	0.8	-0.8	-1.0	-0.6	1.2	-0.8	0.6
Incentive salience index mean	1.0	1.3	3.5	-1.9	-0.5	0.6	0.4	0.5	-0.1	1.6	-1.5	-1.5	-1.2	0.2	-1.3	1.3
Condit. Reinf. lever presses	0.9	1.3	6.0	-2.5	-1.4	1.3	-0.3	-0.2	-0.7	0.8	-0.9	-1.3	-0.9	1.1	-0.8	0.9
Condit. Reinf. active minus inactive responses	0.4	0.7	2.5	0.5	1.6	-1.6	1.1	0.8	-0.2	0.7	-0.2	0.4	0.2	-0.2	-0.1	-0.8
Condit. Reinf. active-inactive response ratio	0.7	1.2	4.9	0.6	2.2	-2.1	1.5	1.3	-0.4	-0.1	0.2	0.4	0.2	-0.3	-0.2	-0.8
Condit. Reinf. active responses	0.2	0.3	1.4	-0.2	0.9	-0.8	0.7	0.4	-0.1	1.2	-0.7	0.1	-0.1	-0.3	-0.2	-0.4
Condit. Reinf. inactive responses	0.2	0.4	2.1	-0.3	-0.1	0.2	0.2	0.0	0.3	1.4	-1.1	-0.4	-0.5	-0.6	-0.4	0.5
Condit. Reinf. lever presses	0.5	0.7	1.8	0.3	-1.2	1.3	-1.3	-1.2	0.8	0.4	-0.0	0.8	0.1	-0.0	1.1	-0.5
Condit. Reinf. lever reinforcers received	0.1	0.2	1.2	-0.1	0.6	-0.5	0.3	0.0	0.1	1.1	-0.5	0.4	0.0	-0.3	0.2	-0.5
Conditioned reinforcement - actives	0.2	0.8	2.0	-0.8	0.5	-0.6	-1.4	-1.4	-1.3	-0.7	0.8	0.7	0.7	1.0	0.7	-0.6
Conditioned reinforcement - inactives	0.4	1.0	2.7	0.0	-0.8	0.5	-1.6	-1.7	-1.2	-1.2	0.9	0.6	0.6	1.1	1.0	-0.6
Conditioned locomotion	0.2	0.3	1.3	-1.1	0.0	-0.1	-0.4	-0.5	-1.0	0.5	-0.3	-0.4	-0.3	0.4	-0.4	0.5
Patch foraging indifference point 0 sec	0.3	0.8	5.9	-2.4	-0.2	0.2	-0.8	-1.2	-0.8	0.0	-0.0	-0.2	-0.0	1.1	0.1	-0.1
Patch foraging indifference point AUC	0.1	0.2	0.8	0.9	-0.6	0.4	-0.3	-0.4	-0.6	0.3	-0.2	-0.4	-0.2	0.4	-0.1	0.5
Delay disc. indifference point, 0s delay	0.4	0.4	3.1	1.8	-1.0	0.7	-0.1	0.0	-0.6	-0.3	0.1	-0.1	-0.2	-0.0	0.4	0.2
Delay disc. indifference point, 16s delay	0.2	0.2	1.2	0.0	0.1	0.3	0.2	-0.1	1.0	-0.3	0.1	0.5	0.0	-1.1	0.3	0.1
Delay disc. indifference point, 2s delay	0.7	0.7	1.9	0.4	-0.9	0.9	-1.4	-1.3	-1.0	-1.0	0.7	0.5	0.7	0.7	0.9	0.2
Delay disc. indifference point, 24s delay	0.2	0.3	1.0	-1.0	0.7	-0.5	0.5	0.4	-0.2	-0.6	0.5	0.5	0.3	-0.3	0.1	-0.6
Delay disc. indifference point, 4s delay	0.8	0.9	3.2	-0.5	0.8	-0.8	-0.5	-0.4	-1.8	-1.3	1.2	0.6	0.9	1.0	0.6	-0.7
Delay disc. indifference point, 8s delay	0.3	0.5	1.2	-0.9	-0.1	0.2	-0.4	-0.4	-1.0	-1.1	1.0	0.7	0.7	0.6	0.7	-0.6
Indifference point function ln k	0.2	0.7	1.4	-1.2	0.5	-0.5	-0.7	-0.3	0.2	-1.1	1.1	0.9	0.8	0.8	0.8	-1.1
Indifference point function log k	0.2	0.7	1.4	-1.2	0.5	-0.5	-0.7	-0.3	0.2	-1.1	1.1	0.9	0.8	0.8	0.8	-1.1
Patch foraging total patch changes 0 sec	0.3	0.8	6.4	-2.5	-0.0	-0.0	-0.8	-1.3	-0.8	0.1	0.0	-0.1	0.1	1.0	0.0	-0.3
Patch foraging total patch changes 12 sec	0.6	0.8	1.7	-1.0	-1.3	1.1	-0.4	-1.1	-0.8	0.7	-0.7	-1.0	-0.4	0.8	-0.5	1.1
Patch foraging total patch changes 18 sec	0.3	0.8	3.2	-0.9	-0.4	0.0	-0.2	-0.6	-1.8	1.1	-0.6	-1.1	-0.2	1.3	-0.9	0.3
Patch foraging total patch changes 24 sec	0.2	0.7	3.1	-1.8	-0.2	0.1	-0.3	-0.7	-1.0	0.9	-0.7	-0.9	-0.3	0.8	-0.8	0.6
Patch foraging total patch changes 6 sec	0.2	0.4	2.0	-1.4	-0.5	0.5	-0.4	-0.9	-0.7	-0.3	0.1	-0.3	-0.1	0.7	0.1	0.1
Patch foraging time to switch 0 sec	0.1	0.5	1.0	0.7	-0.3	0.3	0.8	0.8	0.2	1.0	-0.9	-0.7	-0.3	-0.4	-0.6	1.0
Patch foraging water rate 0 sec	0.1	0.4	1.0	-1.0	1.0	-0.9	0.3	0.1	-0.1	0.3	-0.4	-0.4	-0.8	-0.3	-0.6	0.4
Patch foraging water rate 12 sec	0.4	1.6	3.0	-0.3	-0.4	0.4	-1.5	-1.4	0.2	-1.7	1.7	1.7	1.7	0.5	1.5	-1.5
Patch foraging water rate 18 sec	0.5	1.2	5.5	-2.4	0.1	0.1	-1.0	-1.0	0.1	-1.5	1.4	0.9	1.1	0.6	0.5	-1.1
Patch foraging water rate 24 sec	0.7	1.0	3.1	0.3	-0.2	0.4	-0.9	-1.0	1.1	-1.8	1.5	1.1	0.9	-0.1	0.8	-1.2
Patch foraging water rate 6 sec	0.8	1.2	2.2	-1.1	-0.4	0.5	1.1	1.0	0.9	0.9	-1.2	-1.4	-1.5	-1.0	-1.4	1.3
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.2	0.1	-0.0	0.0	-0.6	-0.6	-0.1	-1.1	1.0	0.9	0.7	0.4	0.8	-1.0
Distance traveled before self-admin	0.4	0.8	2.3	1.5	-1.3	1.0	-0.9	-1.0	-0.2	-0.5	0.6	0.7	0.7	0.7	1.0	-0.4
Distance traveled after self-admin	0.1	0.1	0.6	-0.3	0.1	-0.2	-0.4	-0.4	-0.6	-0.2	0.2	-0.1	0.2	0.8	0.0	0.4
Extensor digitorum longus weight	0.6	2.5	9.2	0.5	-2.8	3.0	-0.8	-0.4	1.7	1.0	-1.5	-1.1	-1.7	-0.7	-0.1	1.9
Bone: elastic displacement	0.1	0.2	1.1	-0.1	-0.2	0.3	-1.0	-0.6	-0.1	0.2	0.1	0.2	0.6	0.2	0.1	-0.0
Bone: elastic work	0.1	0.1	0.5	-0.4	0.3	-0.0	-0.2	0.0	0.7	0.4	-0.3	0.1	-0.0	-0.7	-0.1	0.3
Bone: endosteal estimation	0.5	1.3	2.4	-0.2	1.1	-1.3	1.2	1.2	-1.5	0.8	-1.0	-1.6	-1.2	0.3	-1.3	1.2
Bone: endosteal perimeter	1.7	4.1	15.1	0.5	3.6	-3.9	2.7	2.6	-1.8	0.5	-0.7	-1.3	-1.0	-0.2	-1.8	0.3
Epididymis fat weight	0.7	3.4	12.5	-3.5	1.7	-1.9	-1.1	-1.7	-3.3	-0.6	0.6	-0.4	0.9	2.9	-0.3	-0.1
Delta time in closed arm before/after self-admin	0.3	0.2	0.8	-0.9	-0.4	0.4	0.2	0.3	-0.6	0.3	-0.4	-0.7	-0.5	0.1	-0.7	0.2
Delta time in open arm before/after self-admin	0.5	0.6	1.5	-0.1	1.2	-1.0	0.8	0.7	1.2	0.7	-0.7	-0.1	-0.5	-1.2	-0.4	0.6
Diff in mean of infusions in LGA sessions	0.6	1.1	3.9	2.0	-0.1	0.2	1.0	1.3	1.0	0.5	-0.8	-0.7	-1.1	-1.2	-0.4	1.3
Delay discount exponential model param	0.4	0.5	1.5	0.8	-0.2	0.0	0.6	0.6	1.0	1.2	-1.0	-0.7	-0.7	-0.5	-0.7	0.4
Extinction: sum of active levers before priming	2.7	4.1	11.6	-0.3	-3.4	3.2	-2.9	-2.7	0.1	-1.1	1.2	1.2	1.5	2.0	2.2	-0.5
Active lever presses in extinction session 6	3.9	3.9	8.6	1.6	-1.8	1.7	-2.3	-2.3	0.3	-2.4	2.3	2.4	1.9	0.8	2.9	-1.3
Bone: final force	0.5	0.9	1.7	-0.2	0.6	-0.5	0.9	0.9	0.4	1.2	-1.2	-0.9	-1.3	-1.0	-0.9	1.2
Bone: final moment	0.5	0.8	1.5	-0.3	0.6	-0.5	0.8	0.8	0.3	1.2	-1.2	-0.9	-1.2	-0.9	-0.9	1.2
Food consumed during 24 hour testing period	1.3	2.7	6.8	-0.7	-0.3	0.2	1.3	1.1	-0.9	1.8	-2.2	-2.6	-2.5	-0.1	-2.0	2.2
Glucose	1.6	2.5	6.0	0.5	0.4	-0.2	2.0	2.5	0.8	1.4	-1.6	-1.7	-2.0	-1.7	-1.7	2.0
Heart weight	1.1	1.8	3.5	-0.9	-1.1	0.8	-1.9	-1.0	-1.0	-1.0	1.4	1.4	1.6	1.8	1.7	-1.3
Delay discount hyperbolic model param	0.3	0.4	1.2	0.8	-0.0	-0.1	0.6	0.7	1.0	1.1	-0.8	-0.5	-0.6	-0.6	-0.6	0.1
Intermittent access intake day 1-15 change	0.2	0.8	4.6	-2.1	-0.4	0.6	-0.9	-1.0	-1.0	-0.6	0.5	-0.2	0.4	1.2	0.0	1.0
Intermittent access intake escalation	0.1	0.6	2.6	-1.6	-0.8	0.9	-0.7	-0.8	-0.5	-0.2	0.2	-0.2	0.2	0.8	-0.0	1.2
Intermittent access intake escalation 2	0.1	0.2	0.8	-0.9	-0.5	0.5	-0.2	-0.4	-0.4	-0.3	0.0	-0.3	-0.0	0.8	-0.1	0.7
Intermitt. access day 1 inactive lever presses	0.1	1.8	4.4	-0.3	1.0	-1.2	-1.3	-1.0	-2.1	-2.0	1.7	0.9	1.2	1.5	0.9	-1.3
Intermitt. access day 15 inactive lever presses	0.1	0.3	1.2	1.1	-0.0	0.0	-0.5	-0.5	-0.2	-0.7	0.6	0.6	0.6	-0.1	0.7	-0.4
Intermitt. access escalation Index	0.3	0.9	2.7	-1.0	0.4	-0.7	-0.7	-0.6	-1.5	-0.7	1.0	0.4	1.2	1.6	0.4	-1.1
Intermittent access day 1 total infusions	0.3	1.0	2.9	0.7	0.1	-0.2	-1.7	-1.7	-0.7	-0.8	1.0	1.2	0.9	0.6	1.1	-0.9
Intermittent access day 15 total infusions	0.9	2.2	6.4	-0.7	-1.0	0.9	-2.5	-2.5	-1.4	-1.2	1.4	1.2	1.3	1.6	1.4	-0.4
Intermittent access terminal intake (last 3 days)	1.2	2.0	5.5	-0.8	-0.2	0.0	-2.2	-2.3	-1.6	-1.3	1.4	1.2	1.4	1.8	1.2	-0.8
Intermittent access total infusions	1.2	1.4	3.6	-0.3	0.2	-0.3	-1.9	-1.9	-1.3	-0.9	1.2	1.2	1.2	1.3	1.1	-0.9
Intermittent access day 1 locomotion	0.5	0.8	2.1	0.6	-0.5	0.4	-1.3	-1.5	-0.7	-1.0	0.9	1.0	0.6	0.5	1.1	-0.9
Intermittent access day 15 total locomotion	0.3	1.3	4.2	-1.1	-0.5	0.2	-1.8	-1.6	-2.0	-0.6	0.6	0.5	0.5	1.9	0.8	-0.3
Intermittent access total locomotion	0.4	0.5	1.5	0.6	-0.4	0.2	-1.2	-1.1	-0.6	-0.4	0.5	0.7	0.3	0.6	0.9	-0.3
Intermittent access standard deviation	0.4	2.1	4.7	-1.6	0.1	-0.3	-2.0	-1.8	-1.8	-1.7	1.6	0.7	1.5	2.2	0.7	-0.6
Left kidney weight	0.1	0.6	1.9	-1.4	-0.2	-0.1	-0.6	-1.3	-1.4	0.8	-0.6	-0.4	0.2	1.0	-0.2	0.2
Right kidney weight	0.3	1.9	5.1	-2.2	0.2	-0.4	0.5	-0.2	-0.9	2.3	-1.9	-1.7	-1.2	0.2	-1.5	1.8
Cocaine induced anxiety	0.1	0.2	1.2	1.1	0.2	-0.1	0.5	0.6	0.4	-0.6	0.3	-0.0	-0.1	-0.4	-0.1	0.6
Post-drug Anxiety	0.3	0.4	1.3	0.1	0.2	0.0	0.9	0.9	0.4	-0.0	-0.3	-0.7	-0.6	-0.6	-0.7	1.2
Baseline Anxiety	0.3	0.5	3.4	-1.9	-0.0	0.1	-0.6	-0.5	-1.1	-0.2	0.1	-0.2	0.2	0.9	0.0	0.1
Tail length	1.3	6.9	27.9	-5.3	3.7	-3.8	0.3	-0.1	-4.1	0.6	-0.5	-1.7	-0.0	2.9	-2.1	0.4
Length with tail	1.6	7.2	21.8	-4.6	4.5	-4.7	0.4	0.2	-4.2	0.8	-0.5	-1.3	0.3	2.6	-1.9	0.3
Length without tail	0.2	1.1	5.8	-0.6	2.3	-2.4	-0.1	-0.3	-1.4	0.2	-0.0	0.0	0.5	0.5	-0.1	0.2
Times rat made contact with spout	0.7	0.9	4.2	1.0	-2.0	1.6	-0.8	-0.7	-0.5	-0.3	0.2	0.0	-0.0	1.2	0.6	-0.2
Lifetime Intake	1.5	1.8	4.2	-0.3	0.3	-0.5	-2.1	-1.9	-1.7	-1.0	1.4	1.4	1.4	1.5	1.2	-1.4
Liver weight, left	0.4	0.7	3.2	-1.1	0.8	-0.9	-0.3	0.0	-1.8	0.2	-0.4	-1.0	-0.5	0.8	-0.7	1.0
Liver weight, right	0.2	0.4	1.4	-0.9	0.9	-1.0	0.4	-0.9	-1.2	0.2	-0.0	-0.2	0.5	0.1	-0.4	-0.2
Locomotor activity	0.5	0.8	2.1	1.4	-1.0	0.9	-1.2	-1.5	0.3	-0.9	0.7	0.7	0.4	0.1	1.3	-0.0
Locomotor testing distance	0.3	0.7	1.6	1.1	-1.3	1.0	-1.1	-1.2	-0.3	-0.6	0.4	0.4	0.2	0.6	1.1	-0.1
Locomotor testing rearing	0.3	1.0	3.8	2.0	-1.7	1.5	0.3	-0.2	0.7	0.7	-0.8	-0.5	-1.0	-0.4	0.3	1.2
Locomotion in novel chamber	0.6	0.8	2.2	1.3	0.1	0.1	1.0	1.1	1.5	0.4	-0.6	-0.3	-1.0	-1.3	-0.1	0.8
Locomotion in novel chamber post-restriction	0.3	0.8	6.5	2.5	-0.1	-0.2	0.5	0.7	0.7	-0.8	0.4	0.4	-0.1	-0.3	0.3	-1.2
Fecal boli incidents, locomotor time 1	0.1	0.4	1.2	-0.5	-0.8	0.4	-0.7	-0.9	-0.5	0.6	-0.3	-0.4	0.2	1.1	-0.1	0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.1	0.9	-0.8	0.6	0.6	-0.6	-0.6	0.5	0.2	0.2	0.0	-0.1	-0.9
Time >=10cm from walls, locomotor time 1	0.6	0.8	5.3	-2.3	0.0	-0.2	-0.4	-0.4	-1.2	0.4	-0.3	-0.7	0.0	1.4	-0.7	-0.1
Bouts of movement, locomotor time 1	0.9	1.2	3.5	1.4	-0.9	1.0	-0.1	-0.3	1.9	-0.6	0.8	1.7	0.9	-1.0	1.2	-1.1
Total resting periods, locomotor time 1	1.0	1.1	3.8	0.5	-0.9	1.1	-0.4	-0.6	1.9	-0.7	0.9	1.7	0.9	-0.8	1.2	-1.0
Rest time, locomotor task time 1	0.6	1.0	4.6	-2.1	0.3	-0.4	-1.2	-1.3	-0.7	-0.4	0.7	0.5	0.9	1.5	0.3	-0.7
Distance moved, locomotor task time 1	0.6	1.7	3.9	1.0	0.1	0.0	1.6	2.0	0.3	1.3	-1.5	-1.4	-1.8	-1.5	-1.1	1.3
Vertical activity count, locomotor time 1	0.6	4.1	8.0	0.6	0.9	-0.9	2.8	2.8	-0.4	2.1	-2.2	-2.6	-2.3	-1.6	-2.7	2.2
Time >=10cm from walls, locomotor time 2	0.4	1.3	3.3	-0.1	1.2	-0.9	1.5	1.4	1.1	1.2	-1.3	-0.6	-0.8	-1.8	-1.1	0.6
Bouts of movement, locomotor time 2	0.5	1.5	3.3	-1.2	-0.8	1.0	-1.7	-1.3	0.5	-1.1	1.3	1.8	1.1	0.5	1.8	-1.0
Total resting periods, locomotor time 2	0.4	1.5	3.3	-1.6	-0.8	1.0	-1.8	-1.4	0.3	-1.1	1.3	1.7	1.1	0.8	1.6	-0.8
Rest time, locomotor task time 2	0.4	0.7	2.4	-1.5	0.0	-0.1	-0.7	-0.9	-0.8	-0.6	0.7	0.3	0.9	1.5	0.4	-0.3
Distance moved, locomotor task time 2	1.1	1.4	4.2	1.3	0.4	-0.1	1.3	1.9	1.3	0.8	-1.1	-0.6	-1.4	-2.0	-0.7	0.5
Vertical activity count, locomotor time 2	2.3	5.5	12.1	1.3	1.5	-1.5	3.4	3.5	0.5	2.5	-2.5	-2.4	-2.4	-2.5	-2.8	1.7
Light reinforcement 1	1.4	6.4	14.6	-1.0	-1.6	1.4	1.7	1.5	-0.3	3.3	-3.6	-3.8	-3.4	-0.5	-3.0	3.6
Light reinforcement 2	2.7	6.1	13.7	-2.3	-0.3	0.3	2.0	1.7	0.2	3.7	-3.7	-3.4	-3.2	-1.1	-3.2	2.5
Bone: marrow area	0.5	1.2	2.3	-0.2	1.1	-1.2	1.2	1.2	-1.4	0.8	-1.0	-1.5	-1.2	0.3	-1.3	1.2
Bone: maximum diameter	0.8	1.6	7.2	0.5	2.6	-2.7	1.6	1.5	-1.0	-0.4	0.1	-0.4	-0.5	-0.3	-0.9	-0.3
Bone: maximum force	0.4	0.8	2.0	-0.2	1.4	-1.2	1.0	0.9	0.1	0.7	-0.8	-0.7	-1.2	-0.9	-0.8	0.9
Bone: maximum moment	0.4	0.8	2.0	-0.3	1.4	-1.3	0.9	0.9	-0.1	0.8	-0.9	-0.8	-1.1	-0.8	-0.8	0.8
Mean time between licks in bursts	0.1	0.4	2.0	-1.4	0.3	-0.2	0.2	0.5	-0.4	0.6	-0.7	-0.9	-0.6	0.4	-0.7	0.7
Mean num. licks in bursts	0.3	0.7	3.1	1.7	-1.8	1.5	-0.2	0.1	0.6	-0.1	-0.1	-0.2	-0.4	-0.1	0.3	0.6
Cd content in liver	0.1	0.2	0.8	0.0	0.3	-0.5	0.5	0.2	-0.1	0.9	-0.5	0.3	0.2	-0.0	0.1	-0.5
Co content in liver	1.1	1.3	5.8	-2.4	-1.5	1.7	-0.2	-0.2	0.5	1.1	-1.1	-1.0	-1.0	0.2	-0.6	1.0
Cu content in liver	0.6	0.7	2.1	0.3	-0.7	0.8	0.4	0.8	1.4	1.0	-1.0	-0.4	-0.8	-1.2	-0.4	0.6
Fe content in liver	0.3	0.4	1.2	-1.0	0.3	-0.1	-0.5	-0.3	0.3	-1.1	1.1	0.6	0.7	0.3	0.2	-0.6
K content in liver	0.9	0.9	2.0	1.0	1.2	-1.4	-0.5	-0.3	-1.1	-1.0	1.1	0.8	1.1	0.7	0.7	-0.7
Mg content in liver	0.7	0.7	2.5	0.5	1.6	-1.6	0.9	0.8	-0.5	-0.9	0.8	0.4	0.6	-0.2	0.1	-0.6
Mn content in liver	0.7	0.8	3.4	0.2	1.8	-1.8	0.6	0.9	-1.2	-0.4	0.3	-0.2	0.1	0.0	-0.5	-0.1
Na content in liver	0.2	0.3	1.0	0.4	0.8	-1.0	-0.4	-0.0	-1.0	0.0	0.1	0.1	0.2	0.4	0.2	-0.5
Rb content in liver	0.2	0.2	0.9	0.4	-0.5	0.6	0.3	0.1	0.9	0.3	-0.3	-0.1	-0.3	-0.5	-0.1	0.5
Se content in liver	1.8	2.1	5.7	0.5	1.4	-0.9	2.3	2.1	2.1	0.4	-0.7	-0.6	-1.0	-2.4	-1.2	1.1
Sr content in liver	0.6	0.5	1.4	0.1	0.6	-0.6	-1.2	-0.8	-0.6	-0.4	0.6	0.7	0.9	0.7	0.7	-0.9
Zn content in liver	0.4	0.4	1.2	-0.5	0.3	-0.2	1.1	1.0	-0.2	0.7	-0.6	-0.8	-0.6	-0.3	-0.8	0.7
Bone: minimum diameter	1.2	2.4	5.6	-0.7	2.4	-2.4	1.9	1.8	-1.2	0.7	-1.0	-1.7	-1.4	-0.3	-1.8	1.2
Time in familiar zone, hab. session 1	1.8	2.0	4.5	-0.5	-1.9	2.1	0.6	0.7	1.1	1.1	-1.4	-1.7	-1.8	-0.5	-1.1	2.1
Time in novel zone, hab. session 1	3.4	3.8	7.2	0.8	0.6	-0.8	-2.3	-2.2	-1.0	-2.1	2.3	2.5	2.5	1.3	2.3	-2.7
Total zone transitions, hab. session 1	0.2	0.2	0.7	0.6	-0.8	0.6	-0.5	-0.2	-0.3	0.0	-0.3	-0.5	-0.6	0.3	0.2	0.8
Total locomotion distance, hab. session 1	0.2	0.2	1.2	0.1	-0.3	0.3	0.1	0.5	-0.3	0.2	-0.4	-0.8	-0.7	0.1	-0.4	1.1
Locomotion velocity, hab. session 1	0.4	0.6	1.7	-0.3	-0.1	0.1	0.7	1.1	-0.5	0.7	-0.9	-1.2	-1.0	0.0	-0.9	1.3
Time in familiar zone, hab. session 2	0.9	1.1	2.3	-1.0	-0.3	0.5	0.7	1.0	0.3	1.2	-1.3	-1.4	-1.5	-0.7	-1.3	1.2
Time in novel zone, hab. session 2	0.3	0.3	0.8	0.5	0.3	-0.3	-0.3	-0.4	0.5	-0.6	0.6	0.9	0.9	-0.1	0.8	-0.5
Total zone transitions, hab. session 2	0.2	0.2	0.5	0.6	-0.5	0.1	0.1	0.3	-0.7	0.7	-0.6	-0.4	-0.4	0.5	0.0	0.3
Total locomotion distance, hab. session 2	1.5	1.9	4.5	0.4	0.4	-0.4	2.0	2.1	0.2	1.7	-1.7	-1.5	-1.5	-1.0	-1.5	1.6
Locomotion velocity, hab. session 2	1.3	1.7	3.9	0.4	0.2	-0.2	1.9	2.0	0.2	1.6	-1.6	-1.5	-1.5	-0.8	-1.4	1.6
Novel to familiar place preference ratio	0.3	0.4	1.6	1.3	-0.5	0.5	-0.2	-0.3	0.1	-1.0	0.7	0.6	0.7	0.0	0.8	-0.4
Novelty place preference	0.1	0.2	1.0	1.0	-0.6	0.6	-0.1	-0.1	0.2	-0.5	0.3	0.2	0.3	-0.2	0.5	0.1
Time in novel zone, NPP test	0.2	0.3	0.6	0.7	-0.7	0.7	-0.4	-0.3	0.0	-0.7	0.4	0.3	0.5	0.1	0.6	-0.1
Total zone transitions, NPP test	0.5	0.7	1.9	-0.2	0.1	-0.5	0.4	0.6	-1.4	1.0	-1.0	-1.3	-0.9	0.9	-0.8	0.8
Total locomotion distance, NPP test	0.4	0.5	2.6	-0.1	0.7	-1.1	-0.0	0.3	-1.6	-0.1	0.2	-0.1	0.4	1.3	-0.1	-0.4
Locomotion velocity, NPP test	0.4	0.6	2.3	-0.0	1.2	-1.5	0.5	0.7	-1.5	0.2	-0.1	-0.4	0.0	1.0	-0.5	-0.0
Intraocular pressure	0.8	1.3	5.1	0.3	-1.2	1.1	-1.7	-2.3	-0.1	-1.0	1.0	0.9	1.0	0.9	1.3	-0.4
Delta distance traveled before/after self-admin	0.2	0.2	0.8	-0.1	0.9	-0.7	0.3	0.5	-0.3	-0.0	-0.1	-0.4	-0.4	-0.2	-0.4	0.6
Delta ambulatory time before/after self-admin	0.5	0.8	1.8	-1.2	0.8	-0.6	0.6	0.8	-0.9	0.5	-0.7	-1.3	-1.0	0.2	-1.1	1.2
Parametrial fat weight	0.4	0.8	3.4	-0.9	1.6	-1.8	0.7	0.8	-1.4	-0.2	0.1	-0.3	-0.1	0.4	-0.5	-0.5
Pavlov. Cond. lever latency	0.2	0.3	1.2	1.1	-0.1	0.1	-0.0	0.0	0.2	-0.3	0.5	0.6	0.6	-0.2	0.4	-0.9
Pavlov. Cond. magazine entry latency	0.4	0.5	1.6	0.4	-1.1	1.3	-0.8	-0.6	0.9	0.5	-0.5	-0.0	-0.5	-0.4	0.4	0.4
Pavlov. Cond. change in total contacts	0.5	0.6	1.2	-0.7	-0.3	0.5	0.6	0.7	0.3	0.9	-1.0	-0.9	-1.0	-0.5	-0.7	1.1
Pavlov. Cond. index score	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.6	-0.4	0.2	0.3	-0.2	-0.0	-0.2	0.0	0.3	0.4
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.2	-0.2	0.3	-0.3	-0.2	0.2	0.4	-0.4	-0.2	-0.5	-0.1	0.1	0.6
Pavlov. Cond. lever contacts	0.1	0.1	0.4	-0.6	-0.1	0.1	-0.3	-0.3	0.2	0.2	-0.3	-0.2	-0.3	0.0	0.0	0.5
Pavlov. Cond. magazine entry number	0.2	0.3	0.5	-0.3	0.7	-0.7	0.7	0.5	-0.7	-0.7	0.5	0.0	0.4	0.2	-0.3	-0.3
Pavlov. Cond. intertrial magazine entries	1.2	1.5	3.1	-1.4	1.8	-1.4	1.5	1.5	-0.1	1.2	-1.0	-0.9	-0.7	-0.8	-1.6	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.1	0.2	0.2	-0.0	0.1	-0.2	-0.0	0.4	0.3	-0.3	0.1	-0.3	-0.3	0.3	0.3
Pavlov. Cond. response bias	0.3	0.4	1.0	-0.6	-1.0	1.0	-0.7	-0.5	0.3	0.7	-0.6	-0.3	-0.4	0.2	0.1	0.6
Pavlov. Cond. lever latency	1.1	1.5	4.3	1.0	2.1	-2.1	1.3	1.2	-0.5	-1.8	1.4	0.5	0.8	-0.4	-0.2	-0.6
Pavlov. Cond. magazine entry latency	1.7	2.5	6.8	-1.4	-1.3	1.3	0.0	-0.1	0.3	2.6	-2.5	-1.9	-2.0	-0.5	-1.3	1.9
Pavlov. Cond. change in total contacts	0.5	1.2	4.7	-0.2	-2.2	2.0	-1.4	-1.5	0.6	0.8	-0.5	0.3	0.0	0.6	0.8	-0.2
Pavlov. Cond. index score	1.3	2.0	5.2	-1.1	-2.3	2.3	-0.9	-0.9	0.6	2.2	-1.9	-1.0	-1.3	0.1	-0.3	1.1
Pavlov. Cond. latency score	1.3	2.0	5.2	-1.1	-2.2	2.1	-0.9	-1.0	0.5	2.3	-2.0	-1.1	-1.4	0.1	-0.3	1.2
Pavlov. Cond. lever contacts	1.1	1.6	5.2	-1.1	-2.3	2.3	-1.2	-1.2	0.6	1.7	-1.4	-0.5	-0.8	0.4	0.1	0.7
Pavlov. Cond. magazine entry number	1.8	2.3	6.0	1.3	1.7	-1.8	0.2	0.3	-0.6	-2.4	2.3	1.7	1.9	0.4	1.0	-1.8
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.5	0.3	0.6	-0.7	0.2	0.0	-0.4	-0.0	0.1	0.2	0.4	0.4	0.0	-0.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.0	5.2	-1.2	-2.2	2.2	-0.8	-0.8	0.5	2.3	-2.0	-1.1	-1.3	0.1	-0.4	1.2
Pavlov. Cond. response bias	1.2	1.6	4.3	-1.4	-1.7	1.8	-0.8	-0.8	0.8	2.1	-1.8	-0.9	-1.2	-0.1	-0.3	1.0
Time in closed arm before self-admin	0.8	1.4	4.0	0.3	-0.9	0.5	-1.5	-1.6	-1.6	-1.3	1.2	0.5	0.8	2.0	0.8	-0.6
Time in closed arm after self-admin	0.4	0.5	1.3	-0.3	-1.1	0.9	-0.2	-0.2	-1.1	-0.4	0.2	-0.7	-0.5	1.1	-0.5	0.1
Time in open arm before self-admin	0.3	0.3	0.7	0.0	0.1	0.0	0.8	0.8	0.6	0.7	-0.7	-0.4	-0.5	-0.8	-0.3	0.6
Time in open arm after self-admin	0.5	0.5	2.9	0.6	0.9	-0.6	0.2	0.1	1.7	0.3	-0.2	0.7	0.2	-1.2	0.7	0.3
Bone: periosteal estimation	0.8	1.9	4.2	-0.2	2.0	-2.1	1.6	1.6	-1.3	0.8	-1.0	-1.5	-1.4	-0.1	-1.5	1.1
Bone: periosteal perimeter	1.2	2.3	9.1	0.6	2.9	-3.0	2.0	2.0	-1.3	0.2	-0.3	-0.7	-0.7	-0.3	-1.2	-0.1
Bone: post-yield work	0.3	0.5	1.0	-0.7	0.9	-0.8	0.9	0.8	-0.6	0.0	-0.3	-1.0	-1.0	0.1	-1.0	0.5
Progressive ratio test 1 active lever presses	0.6	1.1	1.8	0.6	0.7	-0.8	-1.2	-1.3	-1.0	-1.2	1.3	1.3	0.9	0.4	1.2	-1.3
Progressive ratio test 1 breakpoint	0.7	1.1	1.9	0.6	0.7	-0.8	-1.1	-1.3	-0.9	-1.2	1.3	1.3	0.9	0.3	1.2	-1.4
Progressive ratio test 1 inactive lever presses	0.4	1.2	4.5	-0.1	2.1	-2.1	-0.0	-0.1	-1.3	-1.3	1.1	0.6	0.7	0.2	0.2	-0.9
Progressive ratio test 2 active lever presses	0.8	1.2	1.8	1.0	-0.3	-0.0	-1.3	-1.3	-1.2	-1.1	1.2	1.1	1.0	1.1	1.2	-1.4
Progressive ratio test 2 breakpoint	0.9	1.1	1.8	1.0	-0.3	-0.0	-1.3	-1.3	-1.2	-1.0	1.2	1.1	1.0	1.0	1.2	-1.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	0.6	-0.3	0.1	-0.7	-0.7	-0.6	-0.5	0.4	0.2	0.1	0.4	0.3	-0.2
Incentive Sensitization - Responses	0.2	0.6	4.1	2.0	-1.2	0.9	-0.3	-0.1	-0.0	-0.2	0.2	0.3	0.3	0.2	0.5	-0.4
Incentive Sensitization - Breakpoint	0.2	0.4	3.5	1.9	-1.1	0.8	-0.2	0.0	-0.1	-0.1	0.1	0.2	0.2	0.3	0.4	-0.3
Sum of active levers in priming session hrs 5-6	3.6	3.4	9.7	0.5	-2.8	3.1	0.3	0.2	1.9	1.6	-1.8	-1.5	-1.9	-1.4	-0.6	2.8
Progressive ratio	0.2	0.6	1.9	1.2	-1.4	1.3	-0.0	-0.1	1.0	0.8	-0.7	-0.5	-0.5	-0.4	-0.2	0.9
Food seeking constrained by brief footshock	1.2	1.5	4.4	-1.1	1.3	-1.3	-0.9	-1.0	-2.1	-1.2	1.3	0.9	1.4	1.4	0.8	-1.0
Seeking ratio, punishment vs. effort	0.5	1.2	3.6	-1.9	1.9	-1.7	0.1	0.2	-1.6	-0.7	0.7	0.5	0.6	0.5	0.1	-1.0
Retroperitoneal fat weight	0.7	3.1	8.0	-2.0	2.6	-2.8	2.0	2.3	-2.0	0.7	-0.8	-1.6	-0.9	0.3	-2.0	0.6
Reaction time number correct	0.1	0.5	1.7	-0.3	0.0	-0.3	-0.5	-0.6	-0.1	-0.1	0.7	1.1	1.3	0.7	0.7	-1.3
Reaction time mean minus median	0.1	0.6	1.2	0.9	1.1	-0.8	0.1	0.4	0.6	-0.6	0.8	1.1	1.1	-0.5	0.5	-1.0
Reaction time mean minus median AUC	0.1	0.8	2.5	1.6	0.8	-0.6	0.0	0.1	1.0	-0.6	0.8	1.3	1.3	-0.8	0.8	-1.0
Reaction time num false alarms	0.3	0.4	1.2	0.5	-0.2	0.5	-0.3	-0.8	1.1	-0.5	0.5	0.8	0.5	-1.0	0.5	-0.5
Reaction time num false alarms AUC	0.4	0.9	2.5	0.3	-0.5	0.7	-1.0	-1.6	0.8	-1.0	1.0	1.2	1.1	-0.4	1.1	-1.0
Reaction time trials correct on left	0.1	0.5	1.7	-0.3	0.0	-0.3	-0.5	-0.6	-0.1	-0.1	0.7	1.1	1.3	0.7	0.7	-1.3
Reaction time trials on left	0.1	0.4	1.5	-0.1	0.0	-0.3	-0.4	-0.4	0.1	-0.1	0.6	1.1	1.2	0.5	0.6	-1.2
Reaction time mean	0.3	0.7	1.7	1.3	0.6	-0.4	0.3	-0.1	0.7	-0.7	0.8	1.3	1.2	-0.6	1.0	-1.0
Reaction time mean AUC	0.3	0.6	1.5	1.2	0.6	-0.4	0.2	-0.1	0.7	-0.6	0.7	1.2	1.0	-0.6	0.9	-0.9
Median of all reaction times	0.3	0.5	1.3	1.0	0.3	-0.1	0.1	-0.4	0.5	-0.6	0.7	1.1	1.0	-0.4	1.0	-0.8
Reaction time omissions	1.4	2.3	8.0	2.8	-0.2	0.4	1.5	1.8	2.4	0.7	-0.8	-0.1	-0.9	-2.7	-0.4	1.1
Reaction time false alarm rate	0.4	0.5	1.4	0.2	-0.4	0.8	-0.8	-1.2	0.8	-0.9	0.6	0.6	0.4	-0.7	0.7	-0.3
Reaction time premature initiation rate	0.5	0.7	1.6	-0.1	-1.1	1.2	0.3	0.2	0.5	1.1	-1.2	-1.0	-1.0	-0.4	-0.7	1.3
Reaction time premature initiations	0.1	0.3	1.0	-0.0	-1.0	0.9	0.1	0.1	0.4	0.9	-0.7	-0.3	-0.2	-0.0	-0.3	0.3
Std. dev. reaction times	0.3	0.8	1.8	1.1	1.3	-1.0	0.2	0.1	0.5	-1.0	1.0	1.2	1.4	-0.5	0.7	-0.9
Reaction time trials completed	0.1	0.4	1.5	-0.1	0.0	-0.3	-0.4	-0.4	0.1	-0.1	0.6	1.1	1.2	0.5	0.6	-1.2
Reaction time trials AUC	0.1	0.4	1.4	-0.2	0.1	-0.4	-0.4	-0.4	0.1	-0.1	0.6	1.1	1.2	0.5	0.6	-1.2
Run reversals in cocaine runway, females	1.7	1.9	6.1	-0.5	2.5	-2.3	1.9	1.5	0.5	1.3	-0.9	-0.6	-0.5	-1.2	-1.6	-0.2
Run reversals in cocaine runway, males	1.9	2.1	4.2	-1.3	-0.4	0.4	-1.9	-2.0	-0.4	-1.8	1.6	1.5	1.5	1.2	1.5	-1.7
Latency to leave start box in cocaine runway	0.3	0.4	3.1	1.8	0.0	-0.0	0.6	0.4	0.5	0.2	-0.2	0.2	-0.1	-0.8	0.3	0.4
Latency to leave start box in cocaine runway, F	0.9	1.1	10.6	3.3	-0.5	0.5	0.2	0.1	0.6	-0.6	0.6	0.8	0.5	-0.8	1.0	0.2
Latency to leave start box in cocaine runway, M	0.7	0.6	1.6	-1.0	0.4	-0.4	0.8	0.6	0.1	1.3	-1.2	-0.8	-0.8	-0.3	-0.9	0.6
Std. dev. time between licks in bursts	0.2	0.3	2.1	-1.4	0.7	-0.6	0.3	0.1	-0.7	-0.2	0.1	-0.3	-0.2	0.7	-0.3	-0.1
Total sessions with >9 infusions	2.5	3.1	5.3	0.8	-0.2	-0.1	-2.0	-2.0	-1.7	-1.8	2.2	2.1	2.0	1.3	2.1	-2.3
Short access day 1 total inactive lever presses	0.2	0.5	2.2	-0.8	1.1	-1.1	-0.3	0.1	-1.5	-0.0	-0.1	-0.4	-0.6	0.4	-0.3	0.2
Short access day 10 total inactive lever presses	0.2	1.1	4.2	0.8	-0.4	-0.0	-1.0	-1.2	-2.1	-1.2	0.9	0.2	1.0	1.6	0.8	-0.3
Short access day 1 total infusions	2.6	5.2	10.9	0.0	1.7	-2.2	-2.0	-2.0	-2.9	-1.9	2.6	2.3	2.8	2.3	1.8	-3.3
Short access day 10 total infusions	0.6	1.1	2.0	1.1	0.4	-0.6	-1.4	-1.4	-1.0	-0.9	1.2	1.2	0.9	0.7	1.0	-1.1
Short access total infusions	1.7	2.4	4.6	0.6	0.6	-0.9	-1.9	-1.8	-1.8	-1.3	1.8	1.7	1.7	1.4	1.5	-2.1
Short access day 1 locomotion	1.2	2.0	5.5	0.2	0.8	-1.2	-1.2	-1.3	-2.3	-1.2	1.6	1.3	1.8	1.8	1.2	-1.3
Short access day 10 total locomotion	0.2	0.7	2.7	1.6	-0.7	0.5	-0.6	-0.6	-0.6	-0.8	0.8	1.0	0.5	0.3	1.2	-0.9
Short access total locomotion	0.9	1.4	2.4	0.7	0.2	-0.4	-1.3	-1.2	-1.5	-1.4	1.5	1.3	1.4	1.1	1.3	-1.1
One hour access (0.3 mA shock)	1.0	1.2	3.4	-1.2	-1.0	0.9	-1.8	-1.7	-1.2	-0.5	0.6	0.4	0.6	1.5	0.7	-0.0
Compulsive drug intake	0.3	0.4	2.7	-1.6	0.4	-0.4	0.2	0.3	-1.0	0.1	0.1	-0.4	0.2	0.9	-0.5	-0.5
One hour access (shock baseline)	0.2	0.7	1.9	0.1	-1.2	1.4	-1.3	-1.2	0.6	-0.0	0.2	0.7	0.4	-0.2	0.8	0.7
Social response proportion	0.4	0.5	1.0	0.8	-0.2	0.2	0.9	1.0	0.2	0.7	-0.6	-1.0	-0.8	-0.2	-0.9	0.6
Social responses	0.9	1.2	5.3	0.6	-2.3	2.0	-0.7	-0.9	-0.9	-0.1	0.0	-0.8	-0.2	1.6	0.2	0.8
Social time	0.2	0.4	1.9	0.3	-0.3	0.2	0.3	-0.3	-0.6	0.3	-0.4	-1.0	-0.5	0.8	-0.5	1.4
Soleus weight	0.4	1.1	3.6	-1.1	0.6	-0.8	-1.3	-0.9	-1.9	-0.8	0.8	0.1	0.7	1.8	0.2	-0.7
Bone: stiffness	1.5	2.6	5.6	0.7	1.4	-1.2	2.4	1.9	1.2	1.4	-1.7	-1.2	-2.2	-2.2	-1.2	1.6
Tibialis anterior weight	0.3	0.9	2.7	-0.3	-1.7	1.6	-1.5	-1.2	-0.5	-0.3	0.2	0.0	0.1	1.2	0.7	-0.1
Time to tail flick, vehicle, before self-admin	1.3	1.6	3.7	-0.5	1.3	-1.4	-1.0	-0.9	-1.9	-1.0	1.3	1.1	1.6	1.4	0.9	-1.2
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.8	0.6	0.3	-0.4	0.6	0.5	0.0	0.9	-0.8	-0.8	-0.4	-0.1	-0.9	0.8
Time to tail flick, test, before self-admin	1.3	1.5	3.2	0.3	0.0	0.2	1.5	1.8	0.6	1.1	-1.4	-1.4	-1.3	-1.3	-1.6	1.6
Time to tail flick, test, after self-admin	0.8	0.8	1.6	-1.2	0.4	-0.1	0.6	0.9	0.3	1.0	-1.1	-1.3	-1.1	-0.6	-1.2	1.0
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	2.4	0.8	-0.1	0.2	1.5	1.3	1.4	1.3	-1.5	-1.4	-1.5	-1.5	-1.5	1.4
Delta time to tail flick, test, before/after SA	0.2	0.3	1.1	-1.1	0.3	-0.2	-0.8	-1.0	-0.0	-0.2	0.3	0.2	0.4	0.6	0.4	-0.3
Tibia length	0.3	0.7	1.5	-0.6	0.5	-0.4	1.2	1.1	0.2	1.2	-1.2	-0.8	-1.0	-0.8	-0.7	0.8
Ambulatory time before self-admin	0.5	1.4	4.9	2.2	-1.1	0.9	-1.1	-1.2	0.1	-1.0	1.1	1.3	1.1	0.5	1.6	-0.7
Ambulatory time after self-admin	0.1	0.1	0.7	0.2	-0.1	0.2	-0.1	0.1	-0.2	-0.0	-0.2	-0.6	-0.5	0.2	-0.2	0.9
Bone: tissue strength	0.2	0.2	0.5	-0.5	0.2	0.0	0.2	0.4	0.6	0.7	-0.6	-0.3	-0.5	-0.5	-0.4	0.3
Total heroin consumption	0.3	0.4	2.2	1.5	-0.8	0.6	-0.1	0.3	0.5	0.5	-0.5	-0.3	-0.5	-0.2	0.3	0.5
Bone: trabecular number	0.2	0.4	1.1	-1.0	0.4	-0.4	-0.6	-0.7	-0.7	-0.8	0.6	-0.0	0.1	1.0	0.0	-0.2
Bone: trabecular spacing	0.1	0.2	0.5	0.6	0.5	-0.7	0.1	0.2	-0.5	0.2	0.0	0.5	0.5	-0.1	0.4	-0.6
Bone: trabecular thickness	0.4	0.6	1.4	-1.1	1.2	-1.0	1.2	1.1	-0.0	-0.3	0.0	-0.5	-0.5	-0.1	-0.9	0.2
Bone: trabecular tissue density	0.4	0.7	2.9	0.5	0.9	-0.6	0.9	0.8	1.4	0.3	-0.4	0.3	-0.4	-1.7	0.2	0.3
Water consumed over 24 hours	0.4	0.8	3.5	0.6	-1.9	1.5	-0.4	-0.7	-0.5	0.4	-0.6	-0.8	-0.9	0.7	-0.2	0.5
Number of responses in last shaping day	2.1	2.7	5.5	1.2	-0.4	0.4	-2.1	-2.0	-0.5	-2.2	2.3	2.0	1.9	1.2	2.1	-0.9