Abca5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Abca5 0.05 0.03 3.1e-05 0.04 0.05 0.04 0.04 1.0e-04 1.5e-05 1.3e-04 5.0e-05
2 OFC gene expression Abca5 0.26 0.13 1.9e-03 0.02 0.14 0.15 0.14 1.3e-01 2.7e-04 2.5e-04 3.1e-04
3 Adipose mRNA stability Abca5 0.03 0.02 4.3e-03 0.02 0.02 0.02 0.02 2.4e-03 3.6e-03 2.5e-03 3.9e-03
4 BLA gene expression Abca5 0.1 0.05 1.0e-03 0.03 0.02 0 0.01 1.7e-02 1.9e-02 2.0e-01 1.3e-01
5 Adipose gene expression Abca5 0.03 0.02 3.3e-03 0.02 0.01 0.01 0.01 2.4e-03 8.1e-03 2.6e-02 2.1e-02
6 Liver gene expression Abca5 0.08 0.04 7.1e-07 0.04 0.05 0.05 0.05 3.9e-05 3.8e-06 3.4e-06 4.3e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bone: apparent density2.84.610.42.52.3-3.2-2.20.90.4
Area under the delay curve0.10.10.30.40.1-0.5-0.2-0.20.5
BMI with tail2.16.713.4-2.1-2.93.71.8-3.1-0.9
BMI without tail2.04.29.6-0.6-2.72.2-0.2-3.1-1.7
Body weight2.49.922.2-1.1-2.84.11.8-4.7-2.9
Weight adjusted by age1.41.63.4-0.7-0.31.91.2-1.8-0.9
Bone surface5.710.119.24.13.3-4.4-3.5-0.6-1.3
Bone volume4.77.915.53.72.7-3.9-3.3-0.5-0.8
Breakpoint value in progressive ratio session0.50.51.6-0.60.7-1.30.50.20.7
Number of licking bursts0.60.61.61.00.8-0.6-0.6-1.3-0.3
Context. condit. distance diff. score0.40.51.2-0.5-0.41.10.30.21.1
Locomotion velocity, session 10.10.10.3-0.4-0.5-0.20.10.0-0.6
Locomotion distance, session 11.62.13.8-1.8-1.90.41.61.60.4
Locomotion velocity, session 21.11.33.1-0.8-1.40.11.01.2-1.8
Locomotion distance, session 21.52.14.8-1.7-1.7-0.41.32.2-0.3
Locomotion velocity, session 33.13.67.2-2.7-2.40.92.01.9-0.6
Locomotion distance, session 30.30.31.2-0.40.1-0.70.11.10.3
Stereotopy head waving bouts, day 32.12.47.5-1.7-0.4-0.21.12.71.7
Stereotopy head waving duration, day 30.40.51.8-0.9-0.3-0.00.51.40.3
Locomotion velocity, session 70.40.41.4-0.10.1-0.90.21.2-0.2
Locomotion distance, session 70.20.20.70.4-0.1-0.8-0.00.7-0.0
Stereotopy head waving bouts, day 70.20.20.5-0.30.4-0.1-0.40.7-0.5
Stereotopy head waving duration, day 70.40.51.0-0.11.0-0.7-0.61.0-0.4
Locomotion velocity, session 80.10.20.7-0.1-0.20.10.8-0.0-0.4
Locomotion distance, session 81.42.14.0-1.7-2.00.81.31.70.5
Degree of sensitization distance0.10.10.20.3-0.5-0.00.2-0.1-0.1
Degree of sensitization stereotypy0.40.41.70.00.30.3-0.7-0.4-1.3
Conditioned locomotion0.20.20.40.3-0.4-0.1-0.6-0.5-0.5
Cocaine response after cond. corrected1.01.12.81.70.9-0.5-1.4-0.90.1
Cocaine response after cond. not corrected1.51.63.71.91.1-0.4-1.7-1.3-0.2
Cocaine response before conditioning0.10.10.4-0.2-0.30.2-0.2-0.6-0.5
Saline control response3.14.110.0-2.8-3.21.52.00.50.6
Bone: connectivity density2.64.011.61.92.0-3.4-1.41.6-0.5
Bone: cortical apparent density4.86.311.2-3.3-2.42.52.81.91.8
Bone: cortical area0.81.25.0-0.7-2.20.40.2-0.8-0.8
Bone: cortical porosity1.71.93.31.80.7-0.7-1.7-1.1-1.7
Bone: cortical porosity2.12.33.41.90.6-0.6-1.8-1.8-1.8
Bone: cortical thickness9.916.329.8-5.4-5.54.14.11.81.4
Bone: cortical thickness3.44.08.0-2.8-2.61.51.51.81.1
Bone: cortical tissue density4.45.810.3-3.2-2.32.42.71.81.7
Condit. Reinf. active minus inactive responses0.60.71.90.3-0.40.8-0.5-1.4-1.0
Condit. Reinf. active-inactive response ratio0.40.40.80.60.80.1-0.9-0.80.4
Condit. Reinf. active responses0.81.02.50.3-0.90.9-0.6-1.2-1.6
Condit. Reinf. inactive responses0.91.13.60.0-1.40.4-0.4-0.7-1.9
Incentive salience index mean0.20.31.20.1-0.20.3-0.4-0.5-1.1
Condit. Reinf. lever presses0.20.30.6-0.8-0.40.40.30.6-0.6
Condit. Reinf. active minus inactive responses2.83.48.01.8-0.30.1-1.9-2.4-2.8
Condit. Reinf. active-inactive response ratio3.03.16.32.10.40.5-1.6-2.2-2.5
Condit. Reinf. active responses1.62.25.71.3-1.0-0.4-1.5-1.5-2.4
Condit. Reinf. inactive responses0.91.13.8-1.0-2.0-0.60.20.7-0.8
Condit. Reinf. lever presses0.81.03.4-0.2-1.90.5-0.4-0.6-1.4
Condit. Reinf. lever reinforcers received1.21.73.91.1-1.1-0.1-1.4-1.4-2.0
Conditioned reinforcement - actives1.51.52.81.01.1-1.7-1.70.9-0.5
Conditioned reinforcement - inactives0.10.10.30.3-0.30.1-0.20.60.1
Conditioned locomotion0.40.51.11.00.1-0.4-0.4-0.7-1.1
Patch foraging indifference point 0 sec2.84.513.8-1.5-3.72.31.9-0.8-1.2
Patch foraging indifference point AUC0.50.61.2-0.8-1.00.61.10.0-0.4
Delay disc. indifference point, 0s delay0.20.30.70.00.40.00.70.30.9
Delay disc. indifference point, 16s delay0.80.81.30.70.7-0.9-1.1-1.10.7
Delay disc. indifference point, 2s delay0.20.20.50.0-0.4-0.30.50.70.4
Delay disc. indifference point, 24s delay2.12.04.41.50.9-1.2-2.1-1.7-0.2
Delay disc. indifference point, 4s delay0.20.20.6-0.0-0.20.20.70.50.3
Delay disc. indifference point, 8s delay0.80.81.6-1.1-0.40.41.30.81.0
Indifference point function ln k0.30.41.0-0.3-1.0-0.4-0.50.5-0.8
Indifference point function log k0.30.41.0-0.3-1.0-0.4-0.50.5-0.8
Patch foraging total patch changes 0 sec2.84.514.5-1.6-3.82.31.8-0.8-1.0
Patch foraging total patch changes 12 sec1.62.16.0-1.3-2.41.51.60.0-0.2
Patch foraging total patch changes 18 sec2.93.79.5-2.1-3.12.01.8-0.6-0.5
Patch foraging total patch changes 24 sec1.31.66.0-0.5-2.41.00.3-1.2-0.9
Patch foraging total patch changes 6 sec3.24.79.3-1.2-3.12.91.8-1.7-1.7
Patch foraging time to switch 0 sec1.21.85.91.42.4-1.2-0.8-0.50.7
Patch foraging water rate 0 sec2.03.28.3-1.4-2.92.31.1-0.8-1.2
Patch foraging water rate 12 sec1.52.25.1-2.0-2.31.31.70.0-0.1
Patch foraging water rate 18 sec0.50.71.1-0.9-1.01.10.30.80.6
Patch foraging water rate 24 sec0.70.91.8-1.1-1.1-0.20.01.21.3
Patch foraging water rate 6 sec0.81.11.9-1.4-1.20.80.80.91.1
Seeking ratio, delayed vs. immediate footshock2.02.47.3-0.1-0.41.91.0-2.7-1.3
Distance traveled before self-admin0.70.72.80.20.90.6-0.3-0.51.7
Distance traveled after self-admin0.40.41.7-0.00.60.3-0.4-0.11.3
Extensor digitorum longus weight0.20.61.4-0.60.70.81.2-1.0-0.0
Bone: elastic displacement1.61.83.8-1.8-1.91.30.81.10.4
Bone: elastic work0.70.93.4-1.2-1.90.70.30.30.0
Bone: endosteal estimation12.026.148.67.04.4-4.5-5.6-4.9-3.5
Bone: endosteal perimeter11.022.941.26.43.6-4.6-5.3-4.5-3.7
Epididymis fat weight1.33.06.2-1.0-0.92.51.4-2.41.3
Delta time in closed arm before/after self-admin0.60.61.51.21.1-0.1-0.60.00.5
Delta time in open arm before/after self-admin1.00.92.9-0.3-0.2-1.3-0.61.70.7
Diff in mean of infusions in LGA sessions0.40.51.0-0.7-0.50.91.0-0.4-0.5
Delay discount exponential model param0.20.20.4-0.6-0.10.50.40.3-0.4
Extinction: sum of active levers before priming4.24.27.51.82.1-2.0-2.7-2.30.9
Active lever presses in extinction session 61.21.23.80.10.3-1.7-0.30.61.9
Bone: final force0.40.71.71.10.2-0.6-1.3-0.90.1
Bone: final moment0.40.61.71.00.1-0.4-1.3-0.90.1
Food consumed during 24 hour testing period1.61.94.7-2.2-1.2-0.01.71.50.7
Glucose0.10.10.3-0.10.00.3-0.3-0.40.6
Heart weight1.92.65.20.7-1.41.9-0.3-2.3-2.2
Delay discount hyperbolic model param0.10.10.2-0.40.00.40.20.1-0.4
Intermittent access intake day 1-15 change0.70.71.9-0.7-0.51.21.40.2-0.1
Intermittent access intake escalation0.40.41.1-0.4-0.11.01.00.10.4
Intermittent access intake escalation 20.20.20.60.10.10.80.60.10.7
Intermitt. access day 1 inactive lever presses1.21.33.2-0.3-1.80.81.5-0.7-1.1
Intermitt. access day 15 inactive lever presses0.70.72.6-0.6-0.50.91.60.1-0.6
Intermitt. access escalation Index0.20.20.50.40.20.5-0.7-0.3-0.3
Intermittent access day 1 total infusions0.80.93.0-0.5-1.1-0.2-0.00.9-1.7
Intermittent access day 15 total infusions0.40.51.2-0.5-0.70.50.60.7-1.1
Intermittent access terminal intake (last 3 days)0.20.20.90.1-0.0-0.20.20.9-0.6
Intermittent access total infusions1.01.12.3-0.8-1.30.20.81.0-1.5
Intermittent access day 1 locomotion0.50.51.9-0.2-0.80.30.40.4-1.4
Intermittent access day 15 total locomotion0.80.92.10.1-1.11.40.4-0.1-1.4
Intermittent access total locomotion1.61.83.6-0.9-1.81.31.20.4-1.9
Intermittent access standard deviation0.40.40.7-0.7-0.80.90.80.2-0.3
Left kidney weight0.51.34.3-0.5-1.11.10.8-0.6-2.1
Right kidney weight0.10.30.90.1-0.40.60.4-0.4-0.9
Cocaine induced anxiety0.10.20.50.70.40.5-0.10.10.1
Post-drug Anxiety0.40.41.10.81.1-0.20.10.30.9
Baseline Anxiety0.40.40.8-0.60.2-0.90.60.50.8
Tail length1.13.28.61.5-0.61.0-0.7-2.9-2.6
Length with tail0.82.86.10.4-0.81.81.0-2.3-2.5
Length without tail0.40.82.6-0.60.31.21.60.10.1
Times rat made contact with spout1.01.22.4-0.9-1.51.11.5-0.2-0.6
Lifetime Intake0.91.12.0-0.8-1.4-0.20.51.2-1.4
Liver weight, left0.10.20.90.10.3-0.9-0.30.4-0.3
Liver weight, right0.71.23.0-1.2-0.3-0.31.01.71.3
Locomotor activity0.71.13.4-0.7-1.81.0-0.2-1.2-0.4
Locomotor testing distance1.52.58.0-1.3-2.81.60.4-1.4-0.8
Locomotor testing rearing4.26.413.9-2.2-3.73.52.0-1.7-0.8
Locomotion in novel chamber1.51.84.50.91.4-0.7-1.5-1.02.1
Locomotion in novel chamber post-restriction1.21.45.6-0.5-0.4-0.3-0.51.42.4
Fecal boli incidents, locomotor time 10.70.81.70.81.0-1.3-0.11.20.3
Change in fecal boli incidents, locomotor task0.70.72.8-0.8-0.20.80.10.01.7
Time >=10cm from walls, locomotor time 10.40.41.5-0.3-0.1-1.20.30.90.2
Bouts of movement, locomotor time 11.51.74.7-0.8-1.42.21.1-0.1-1.2
Total resting periods, locomotor time 10.70.72.3-0.4-0.61.50.80.0-0.9
Rest time, locomotor task time 10.20.20.9-0.30.20.51.00.0-0.2
Distance moved, locomotor task time 10.50.51.0-1.0-0.90.60.4-0.00.7
Vertical activity count, locomotor time 10.50.50.8-0.9-0.90.70.9-0.20.1
Time >=10cm from walls, locomotor time 20.80.82.0-1.4-0.41.00.90.21.0
Bouts of movement, locomotor time 21.92.14.6-1.8-1.61.22.20.60.1
Total resting periods, locomotor time 22.02.25.0-1.8-1.61.12.20.90.4
Rest time, locomotor task time 21.82.04.21.32.1-1.8-0.70.91.3
Distance moved, locomotor task time 21.82.14.6-2.2-1.51.81.60.10.4
Vertical activity count, locomotor time 22.12.34.2-1.7-2.01.71.8-0.6-0.2
Light reinforcement 11.32.45.7-2.4-1.9-0.01.31.7-0.4
Light reinforcement 20.30.41.10.20.5-1.1-0.8-0.2-0.3
Bone: marrow area11.925.848.16.94.5-4.4-5.6-4.9-3.4
Bone: maximum diameter3.76.810.93.31.8-3.3-3.2-1.8-1.5
Bone: maximum force0.71.22.31.40.2-1.1-1.5-1.2-0.4
Bone: maximum moment0.61.02.31.30.0-0.8-1.5-1.2-0.4
Mean time between licks in bursts0.40.61.80.71.1-0.1-0.0-1.3-0.3
Mean num. licks in bursts1.31.52.7-1.5-1.70.81.41.20.2
Cd content in liver1.31.44.80.51.2-0.2-0.91.12.2
Co content in liver0.80.91.81.31.40.7-0.7-1.00.0
Cu content in liver0.40.50.80.90.9-0.9-0.80.4-0.0
Fe content in liver0.20.20.6-0.4-0.10.5-0.30.80.4
K content in liver1.61.64.61.00.8-2.1-1.01.40.1
Mg content in liver2.12.15.10.70.9-2.3-1.12.20.5
Mn content in liver2.62.98.10.31.0-2.7-0.92.80.6
Na content in liver0.90.92.50.10.8-1.6-0.31.40.6
Rb content in liver0.30.41.2-0.01.1-0.30.00.70.7
Se content in liver0.40.51.2-0.10.4-1.1-0.31.00.8
Sr content in liver0.40.41.40.0-0.50.40.2-0.7-1.2
Zn content in liver1.92.16.11.21.0-2.5-1.50.9-0.9
Bone: minimum diameter6.111.419.84.51.6-3.0-3.9-3.9-2.6
Time in familiar zone, hab. session 10.70.71.40.90.8-0.1-1.1-0.11.2
Time in novel zone, hab. session 10.90.91.4-1.0-1.20.21.20.4-1.2
Total zone transitions, hab. session 10.81.12.3-1.3-1.51.01.10.3-0.6
Total locomotion distance, hab. session 11.52.14.0-2.0-2.01.21.60.5-0.6
Locomotion velocity, hab. session 11.01.42.8-1.7-1.51.11.40.2-0.7
Time in familiar zone, hab. session 20.90.92.91.00.30.4-0.8-1.7-0.8
Time in novel zone, hab. session 21.61.65.5-0.80.1-1.40.32.31.3
Total zone transitions, hab. session 20.30.41.1-1.1-1.00.00.30.4-0.5
Total locomotion distance, hab. session 21.62.15.6-2.4-1.80.71.41.2-0.0
Locomotion velocity, hab. session 21.52.05.3-2.3-1.60.71.41.2-0.1
Novel to familiar place preference ratio1.61.75.21.1-0.80.9-0.8-2.3-1.3
Novelty place preference1.31.44.11.0-0.50.8-0.8-2.0-1.2
Time in novel zone, NPP test1.21.23.60.9-0.60.8-0.7-1.9-1.2
Total zone transitions, NPP test1.62.35.2-2.2-2.30.41.11.5-0.1
Total locomotion distance, NPP test2.83.98.0-2.8-2.71.01.72.00.5
Locomotion velocity, NPP test3.14.49.2-3.0-2.91.22.01.80.5
Intraocular pressure1.62.27.40.3-1.00.5-0.3-2.2-2.7
Delta distance traveled before/after self-admin0.40.40.9-1.0-0.80.1-0.10.7-0.4
Delta ambulatory time before/after self-admin0.20.20.5-0.1-0.3-0.4-0.70.6-0.3
Parametrial fat weight1.02.03.71.51.9-1.6-1.7-0.00.6
Pavlov. Cond. lever latency0.91.22.00.61.1-1.4-0.71.11.3
Pavlov. Cond. magazine entry latency0.10.20.6-0.1-0.30.7-0.1-0.5-0.2
Pavlov. Cond. change in total contacts1.11.22.3-0.1-0.91.5-0.0-1.4-1.4
Pavlov. Cond. index score0.30.41.0-0.1-0.41.00.1-1.0-0.7
Pavlov. Cond. latency score0.40.50.9-0.2-0.51.00.3-1.0-0.8
Pavlov. Cond. lever contacts0.70.81.3-0.4-0.91.20.5-1.1-1.1
Pavlov. Cond. magazine entry number0.10.20.4-0.2-0.2-0.70.40.5-0.2
Pavlov. Cond. intertrial magazine entries2.93.58.71.2-1.20.6-1.1-2.9-3.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.7-0.2-0.40.80.1-0.9-0.8
Pavlov. Cond. response bias0.30.30.90.1-0.20.8-0.4-0.9-0.5
Pavlov. Cond. lever latency0.50.61.9-0.31.00.60.6-0.11.4
Pavlov. Cond. magazine entry latency0.20.20.60.30.70.0-0.8-0.3-0.1
Pavlov. Cond. change in total contacts0.60.82.20.6-0.2-0.6-1.1-0.7-1.5
Pavlov. Cond. index score0.70.81.90.90.1-0.5-1.4-0.8-1.2
Pavlov. Cond. latency score0.70.91.80.90.0-0.5-1.3-0.8-1.3
Pavlov. Cond. lever contacts0.30.41.2-0.0-1.1-0.5-0.30.5-0.9
Pavlov. Cond. magazine entry number0.20.20.4-0.1-0.2-0.40.70.70.3
Pavlov. Cond. intertrial magazine entries1.01.35.50.80.3-2.3-1.00.90.3
Pavlov. Cond. lever-magazine prob. diff.0.60.81.80.90.1-0.5-1.3-0.7-1.3
Pavlov. Cond. response bias0.20.20.50.4-0.4-0.5-0.70.2-0.6
Time in closed arm before self-admin0.70.82.6-0.6-0.90.3-0.0-0.9-1.6
Time in closed arm after self-admin0.50.51.70.2-0.20.70.0-1.3-0.9
Time in open arm before self-admin0.50.61.0-0.20.91.00.9-0.30.8
Time in open arm after self-admin0.10.10.40.20.7-0.5-0.30.10.1
Bone: periosteal estimation5.511.319.64.41.8-2.9-3.9-3.7-2.8
Bone: periosteal perimeter4.16.811.23.31.3-2.2-2.8-2.9-2.4
Bone: post-yield work1.52.14.21.81.0-2.1-1.6-1.0-0.4
Progressive ratio test 1 active lever presses2.93.05.9-2.1-2.41.01.91.0-1.4
Progressive ratio test 1 breakpoint3.13.36.5-2.0-2.61.11.90.8-1.8
Progressive ratio test 1 inactive lever presses2.12.35.1-1.8-2.20.21.21.4-1.3
Progressive ratio test 2 active lever presses0.70.82.7-0.2-0.80.90.5-0.5-1.6
Progressive ratio test 2 breakpoint0.91.13.0-0.3-0.91.30.8-0.5-1.7
Progressive ratio test 2 inactive lever presses0.40.52.20.4-0.6-0.1-0.1-0.2-1.5
Incentive Sensitization - Responses0.30.30.60.70.20.50.0-0.7-0.7
Incentive Sensitization - Breakpoint0.30.30.70.70.30.60.1-0.8-0.6
Sum of active levers in priming session hrs 5-60.20.20.5-0.10.20.30.3-0.60.7
Progressive ratio2.93.45.71.92.4-2.0-2.0-1.11.3
Food seeking constrained by brief footshock1.01.23.11.10.60.3-1.8-1.0-1.3
Seeking ratio, punishment vs. effort1.82.13.9-1.0-1.82.00.90.3-1.9
Retroperitoneal fat weight1.44.712.0-1.3-1.93.51.7-2.6-1.1
Reaction time number correct0.81.23.10.70.8-1.5-1.80.50.6
Reaction time mean minus median1.21.63.30.91.8-1.2-1.2-0.21.7
Reaction time mean minus median AUC2.02.76.21.11.6-2.5-1.90.61.3
Reaction time num false alarms0.81.12.61.0-0.3-0.8-1.6-1.3-0.6
Reaction time num false alarms AUC1.21.64.21.40.2-1.7-2.1-0.7-0.2
Reaction time trials correct on left0.81.23.10.70.8-1.5-1.80.50.6
Reaction time trials on left0.91.33.30.80.9-1.6-1.80.50.7
Reaction time mean0.30.41.30.31.2-0.1-0.40.00.8
Reaction time mean AUC0.20.20.90.11.0-0.1-0.20.20.6
Median of all reaction times0.10.10.70.10.80.2-0.10.20.2
Reaction time omissions2.33.16.60.71.8-2.6-1.31.52.2
Reaction time false alarm rate0.30.41.10.8-0.3-0.4-0.8-1.0-0.4
Reaction time premature initiation rate1.31.73.2-1.1-1.71.81.70.2-0.1
Reaction time premature initiations0.30.41.2-0.6-1.10.40.40.70.3
Std. dev. reaction times1.42.04.30.81.8-1.4-1.20.72.1
Reaction time trials completed0.91.33.30.80.9-1.6-1.80.50.7
Reaction time trials AUC0.81.22.90.70.9-1.5-1.70.50.7
Run reversals in cocaine runway, females1.91.85.8-0.80.12.41.2-1.40.9
Run reversals in cocaine runway, males1.01.02.81.30.60.7-0.4-1.7-0.7
Latency to leave start box in cocaine runway3.13.37.6-2.5-1.81.72.80.00.1
Latency to leave start box in cocaine runway, F6.26.815.5-2.9-2.82.93.9-0.7-0.4
Latency to leave start box in cocaine runway, M0.30.30.8-0.90.3-0.3-0.00.80.3
Std. dev. time between licks in bursts0.60.71.4-1.1-0.30.81.20.70.6
Total sessions with >9 infusions1.71.94.3-1.8-2.10.11.21.2-1.0
Short access day 1 total inactive lever presses0.50.51.1-0.7-1.00.21.10.1-0.7
Short access day 10 total inactive lever presses0.10.20.30.5-0.1-0.2-0.5-0.50.3
Short access day 1 total infusions1.11.13.3-1.6-1.8-0.20.60.7-0.4
Short access day 10 total infusions2.32.56.5-1.8-2.50.11.11.8-0.9
Short access total infusions1.51.73.8-1.3-1.9-0.20.31.3-1.6
Short access day 1 locomotion2.72.87.0-2.0-2.61.21.71.0-0.7
Short access day 10 total locomotion0.20.20.6-0.1-0.70.5-0.1-0.2-0.8
Short access total locomotion1.92.04.4-1.8-2.10.81.51.1-0.5
One hour access (0.3 mA shock)0.60.72.40.2-0.8-0.5-0.20.9-1.6
Compulsive drug intake0.70.81.71.30.5-0.6-1.2-0.7-0.5
One hour access (shock baseline)0.40.41.30.10.3-1.0-0.21.1-0.2
Social response proportion1.61.72.51.51.4-1.2-1.60.01.4
Social responses0.60.82.3-0.7-0.9-0.30.11.51.0
Social time2.02.65.52.01.9-1.4-2.3-0.50.9
Soleus weight0.92.54.51.81.1-1.2-2.0-2.1-0.7
Bone: stiffness0.71.12.01.40.9-1.0-1.3-0.80.7
Tibialis anterior weight0.30.92.50.60.8-0.5-0.2-1.6-1.2
Time to tail flick, vehicle, before self-admin0.80.82.30.3-0.21.51.50.2-0.3
Time to tail flick, vehicle, after self-admin1.11.22.81.71.2-0.6-1.1-1.00.6
Time to tail flick, test, before self-admin2.92.86.32.51.80.5-1.2-2.2-0.9
Time to tail flick, test, after self-admin0.40.41.21.10.0-0.6-0.4-0.30.8
Delta time to tail flick, vehicle, before/after SA1.51.54.00.90.9-2.0-1.40.81.0
Delta time to tail flick, test, before/after SA0.50.51.00.3-0.4-1.0-0.50.41.0
Tibia length0.82.34.6-0.1-0.52.00.9-2.0-2.1
Ambulatory time before self-admin0.40.41.9-0.10.70.3-0.1-0.31.4
Ambulatory time after self-admin0.50.52.2-0.00.8-0.0-0.6-0.11.5
Bone: tissue strength2.42.35.2-1.8-1.20.41.32.31.5
Total heroin consumption1.21.55.30.81.3-2.3-0.10.70.8
Bone: trabecular number2.64.110.72.02.0-3.3-1.71.80.3
Bone: trabecular spacing2.22.97.8-1.7-1.62.81.5-1.30.1
Bone: trabecular thickness1.41.73.31.80.7-1.7-1.8-0.6-0.1
Bone: trabecular tissue density1.01.42.9-1.6-0.71.51.7-0.10.7
Water consumed over 24 hours2.32.75.5-2.4-1.3-0.01.72.01.4
Number of responses in last shaping day2.22.33.7-1.9-1.81.91.50.6-0.7