Hub : Genes

Abca5

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Abca5	0.05	0.03	5.7e-04	0.04	0.04	0.04	0.04	1.2e-04	8.6e-05	2.0e-04	2.1e-04
2	BLA	gene expression	Abca5	0.07	0.04	2.9e-03	0	0.02	0.01	0	1.9e-01	2.4e-02	1.0e-01	3.1e-01
3	OFC	gene expression	Abca5	0.25	0.14	7.0e-03	0	0.08	0.05	0.04	2.7e-01	6.9e-03	2.2e-02	4.9e-02
4	NAcc	gene expression	Abca5	0.06	0.03	7.0e-06	0.05	0.03	0.03	0.04	7.3e-08	7.0e-06	5.4e-06	2.1e-06
5	Adipose	gene expression	Abca5	0.03	0.02	5.9e-03	0.01	0.01	0	0	1.1e-02	1.3e-02	1.6e-01	7.5e-02
6	Liver	gene expression	Abca5	0.07	0.04	1.3e-06	0.04	0.04	0.04	0.04	1.3e-05	1.2e-05	3.4e-05	6.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.4	2.5	6.3	2.5	2.1	-1.9	0.7	0.1	-0.4
Area under the delay curve	0.1	0.1	0.2	0.2	0.3	0.3	-0.5	-0.2	-0.2
BMI with tail	1.6	5.6	9.9	-1.6	-0.4	2.6	-2.7	-2.7	3.1
BMI without tail	2.5	13.1	25.0	-1.7	-0.6	4.0	-4.3	-4.0	5.0
Body weight	4.2	18.5	37.5	-0.1	1.1	2.8	-6.1	-5.7	5.7
Weight adjusted by age	0.4	1.1	2.7	-0.7	-0.1	0.1	-1.5	-1.6	1.2
Bone surface	4.1	8.1	17.5	4.2	4.1	-2.8	-1.4	-1.4	1.4
Bone volume	3.1	6.3	14.4	3.8	3.8	-2.1	-1.1	-1.5	1.0
Breakpoint value in progressive ratio session	0.3	0.5	1.3	-0.8	-0.7	-0.3	0.6	1.1	-0.1
Number of licking bursts	0.3	1.0	2.2	1.1	1.0	-0.7	-1.5	-0.1	1.0
Context. condit. distance diff. score	0.2	0.3	0.6	-0.6	-0.8	0.4	0.4	0.1	-0.7
Locomotion velocity, session 1	0.1	0.1	0.2	-0.4	0.0	0.4	-0.3	0.2	0.1
Locomotion distance, session 1	1.8	2.3	3.9	-1.8	-1.4	2.0	1.2	0.8	-1.5
Locomotion velocity, session 2	0.3	0.4	1.3	-0.8	-0.5	1.2	0.3	-0.2	0.0
Locomotion distance, session 2	1.6	2.3	3.1	-1.8	-1.3	1.7	1.7	0.9	-1.6
Locomotion velocity, session 3	3.2	3.7	7.8	-2.8	-1.9	2.0	1.5	1.7	-1.0
Locomotion distance, session 3	0.6	0.6	1.5	-0.5	-0.2	-0.2	0.9	1.2	-1.0
Stereotopy head waving bouts, day 3	3.6	4.3	7.2	-1.7	-2.0	0.4	2.7	2.5	-2.3
Stereotopy head waving duration, day 3	1.0	1.2	2.7	-1.0	-1.0	-0.1	1.6	1.3	-0.8
Locomotion velocity, session 7	0.2	0.2	0.7	-0.2	-0.1	-0.0	0.8	0.4	-0.7
Locomotion distance, session 7	0.1	0.1	0.3	0.2	0.3	0.5	0.3	-0.2	-0.5
Stereotopy head waving bouts, day 7	0.7	0.8	1.9	-0.1	-0.1	-1.4	1.2	1.1	-0.2
Stereotopy head waving duration, day 7	1.0	1.3	3.2	-0.1	-0.2	-1.8	1.5	1.4	-0.4
Locomotion velocity, session 8	0.2	0.2	0.6	-0.1	-0.1	0.3	-0.7	-0.8	-0.0
Locomotion distance, session 8	1.7	2.4	3.5	-1.8	-1.5	1.9	1.5	0.7	-1.6
Degree of sensitization distance	0.2	0.2	0.9	0.3	0.0	0.9	-0.2	-0.7	0.2
Degree of sensitization stereotypy	0.2	0.3	0.9	-0.1	0.0	-1.0	0.3	0.2	0.8
Conditioned locomotion	0.2	0.2	0.4	0.3	0.4	0.6	-0.4	0.0	0.5
Cocaine response after cond. corrected	1.3	1.9	3.2	1.8	1.6	-0.3	-1.3	-1.8	1.0
Cocaine response after cond. not corrected	2.0	2.8	4.4	1.9	1.8	-0.6	-1.8	-2.1	1.5
Cocaine response before conditioning	0.1	0.1	0.4	-0.5	-0.1	0.0	-0.2	-0.0	0.6
Saline control response	3.3	4.6	13.2	-2.8	-2.4	3.6	0.6	0.5	-0.4
Bone: connectivity density	1.1	1.7	3.1	1.8	1.2	-1.5	1.4	1.0	-0.4
Bone: cortical apparent density	5.4	8.5	14.3	-3.3	-3.8	2.1	2.7	2.6	-2.7
Bone: cortical area	0.8	1.3	5.9	-0.6	0.2	2.4	-0.5	-0.9	0.6
Bone: cortical porosity	2.3	2.5	4.3	1.9	2.0	-0.9	-1.3	-1.0	2.1
Bone: cortical porosity	2.9	3.2	5.7	1.7	2.1	-0.6	-1.8	-1.5	2.4
Bone: cortical thickness	9.4	15.7	28.4	-5.3	-4.9	4.9	2.7	2.2	-2.4
Bone: cortical thickness	5.6	6.9	9.2	-3.0	-2.8	2.5	2.6	2.6	-2.1
Bone: cortical tissue density	5.0	8.0	13.6	-3.2	-3.7	2.0	2.6	2.5	-2.6
Condit. Reinf. active minus inactive responses	0.7	0.8	2.4	0.2	0.5	0.1	-1.3	-0.7	1.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	0.5	0.4	-0.9	-0.6	0.2	0.4
Condit. Reinf. active responses	0.9	1.2	2.9	0.2	0.7	0.7	-1.4	-1.1	1.7
Condit. Reinf. inactive responses	0.8	1.0	1.9	-0.0	0.8	1.4	-0.9	-1.1	1.2
Incentive salience index mean	0.2	0.2	0.8	0.1	0.2	-0.1	-0.6	-0.1	0.9
Condit. Reinf. lever presses	0.2	0.3	0.6	-0.8	-0.8	0.2	0.5	0.6	-0.3
Condit. Reinf. active minus inactive responses	2.6	4.1	8.6	1.6	2.2	0.2	-2.2	-1.9	2.9
Condit. Reinf. active-inactive response ratio	2.7	4.3	6.5	2.0	2.0	-0.5	-2.5	-2.2	2.5
Condit. Reinf. active responses	1.8	2.5	4.8	1.1	1.8	1.2	-1.5	-1.5	2.2
Condit. Reinf. inactive responses	0.8	1.2	4.8	-1.1	-0.2	2.2	0.9	0.4	0.0
Condit. Reinf. lever presses	0.6	0.9	3.0	-0.1	0.4	1.7	-0.5	-0.8	1.2
Condit. Reinf. lever reinforcers received	1.5	2.1	4.0	1.0	1.5	1.4	-1.3	-1.3	2.0
Conditioned reinforcement - actives	0.1	0.4	0.8	0.6	0.9	-0.3	-0.7	-0.5	0.8
Conditioned reinforcement - inactives	0.3	0.8	3.4	0.6	0.5	0.5	-0.9	-1.8	0.0
Conditioned locomotion	0.9	1.3	3.0	0.3	0.7	0.6	-1.7	-1.4	1.5
Patch foraging indifference point 0 sec	1.6	4.4	16.5	-1.5	-1.0	4.1	-1.2	-1.8	1.5
Patch foraging indifference point AUC	0.2	0.6	1.3	-1.1	-0.9	1.1	0.1	0.2	-0.2
Delay disc. indifference point, 0s delay	0.3	0.4	1.2	-0.1	-0.4	-0.4	-0.0	1.1	-0.9
Delay disc. indifference point, 16s delay	0.5	0.7	1.8	0.8	1.3	-0.5	-0.5	-0.7	0.9
Delay disc. indifference point, 2s delay	0.2	0.3	0.9	0.1	-0.1	0.8	-0.1	0.2	-0.9
Delay disc. indifference point, 24s delay	1.2	1.9	4.1	1.5	2.0	-1.1	-1.3	-0.4	1.5
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.1	-0.5	0.6	-0.4	-0.3	-0.6
Delay disc. indifference point, 8s delay	0.4	0.7	1.1	-1.0	-0.9	0.3	0.2	1.0	-1.0
Indifference point function ln k	0.1	0.3	0.9	-0.4	0.2	1.0	0.4	0.6	0.3
Indifference point function log k	0.1	0.3	0.9	-0.4	0.2	1.0	0.4	0.6	0.3
Patch foraging total patch changes 0 sec	1.6	4.6	17.8	-1.6	-1.1	4.2	-1.3	-1.7	1.3
Patch foraging total patch changes 12 sec	1.3	1.8	7.5	-1.3	-1.2	2.7	-0.1	-0.4	0.3
Patch foraging total patch changes 18 sec	1.2	2.8	8.8	-2.2	-1.4	3.0	-0.5	-0.6	0.6
Patch foraging total patch changes 24 sec	0.8	2.6	6.8	-0.4	0.2	2.6	-1.7	-2.0	1.3
Patch foraging total patch changes 6 sec	2.7	4.5	9.0	-1.3	-0.9	3.0	-2.2	-2.3	2.4
Patch foraging time to switch 0 sec	0.4	1.7	6.3	1.6	1.0	-2.5	-0.3	-0.3	-0.1
Patch foraging water rate 0 sec	0.7	2.7	9.6	-1.5	-1.1	3.1	-0.4	-0.6	1.7
Patch foraging water rate 12 sec	0.5	2.2	6.7	-2.0	-1.6	2.6	-0.3	-0.2	0.1
Patch foraging water rate 18 sec	0.4	0.9	1.5	-1.0	-1.1	0.9	0.7	1.2	-0.7
Patch foraging water rate 24 sec	0.8	1.1	1.5	-1.2	-0.9	1.1	1.0	1.0	-0.9
Patch foraging water rate 6 sec	1.0	1.4	2.3	-1.4	-1.4	1.5	0.6	1.1	-0.7
Seeking ratio, delayed vs. immediate footshock	1.1	1.5	5.5	-0.1	0.2	-0.1	-1.5	-1.2	2.3
Distance traveled before self-admin	0.0	0.1	0.2	-0.4	-0.3	-0.4	0.1	-0.1	-0.2
Distance traveled after self-admin	0.0	0.1	0.2	-0.5	-0.3	-0.1	0.1	-0.1	-0.1
Extensor digitorum longus weight	0.1	0.4	1.4	-0.3	-0.0	-1.2	-0.9	-0.3	0.6
Bone: elastic displacement	2.3	2.9	4.8	-2.2	-1.8	1.6	1.9	1.4	-1.1
Bone: elastic work	1.0	1.3	3.9	-1.4	-0.9	2.0	0.8	0.4	-0.3
Bone: endosteal estimation	14.8	36.2	57.9	7.3	7.6	-3.6	-6.0	-5.5	5.2
Bone: endosteal perimeter	13.0	31.8	54.8	6.7	7.4	-2.7	-5.4	-5.4	5.1
Epididymis fat weight	0.8	3.8	9.2	-0.4	-0.3	1.4	-3.0	-2.7	2.0
Delta time in closed arm before/after self-admin	0.6	0.6	1.4	1.2	0.6	-1.2	0.1	0.2	-0.6
Delta time in open arm before/after self-admin	0.6	0.7	1.9	-0.4	-0.1	0.4	1.4	0.4	-1.3
Diff in mean of infusions in LGA sessions	0.9	1.7	3.2	-1.5	-1.8	0.8	1.6	1.1	-0.6
Delay discount exponential model param	0.1	0.2	0.4	-0.4	-0.5	-0.3	0.6	0.4	0.1
Extinction: sum of active levers before priming	2.3	3.5	6.3	1.6	2.1	-2.0	-2.5	-0.6	1.9
Active lever presses in extinction session 6	0.2	0.2	0.7	0.5	0.5	0.1	0.0	0.4	-0.8
Bone: final force	0.5	0.9	1.5	1.2	1.2	-0.0	-0.8	-1.2	0.3
Bone: final moment	0.5	0.8	1.4	1.1	1.2	0.0	-0.9	-1.2	0.3
Food consumed during 24 hour testing period	1.6	3.3	4.6	-2.1	-2.0	1.3	1.8	2.2	-1.5
Glucose	0.1	0.2	0.4	-0.1	0.6	0.3	-0.3	-0.6	-0.5
Heart weight	1.5	2.5	5.1	0.2	0.7	1.4	-2.1	-1.6	2.3
Delay discount hyperbolic model param	0.2	0.2	0.6	-0.5	-0.5	-0.3	0.8	0.5	0.1
Intermittent access intake day 1-15 change	0.1	0.3	1.0	-0.6	-1.0	0.4	-0.1	-0.1	-0.7
Intermittent access intake escalation	0.1	0.6	1.6	-0.9	-1.3	0.8	0.0	0.1	-0.7
Intermittent access intake escalation 2	0.2	0.4	1.0	-0.2	-1.0	0.2	0.0	0.7	-0.9
Intermitt. access day 1 inactive lever presses	0.2	2.1	6.1	0.3	0.1	1.0	-2.5	-2.0	1.2
Intermitt. access day 15 inactive lever presses	0.1	0.4	1.0	-0.4	-1.0	0.3	-0.4	-0.4	-0.9
Intermitt. access escalation Index	0.0	0.1	0.2	-0.4	-0.5	-0.1	0.4	0.3	0.1
Intermittent access day 1 total infusions	0.3	0.8	2.0	-0.5	0.4	1.4	-0.6	-0.5	1.3
Intermittent access day 15 total infusions	0.3	0.8	1.8	-1.1	-0.7	1.3	-0.9	-0.5	0.8
Intermittent access terminal intake (last 3 days)	0.1	0.3	0.7	-0.3	-0.3	0.6	-0.9	-0.3	0.4
Intermittent access total infusions	0.8	0.9	2.3	-0.6	-0.1	1.5	-1.1	-0.6	1.2
Intermittent access day 1 locomotion	0.5	1.0	1.8	-0.3	0.2	1.3	-0.9	-1.1	1.3
Intermittent access day 15 total locomotion	0.4	1.7	5.3	-0.8	-0.8	2.3	-1.2	-1.1	0.8
Intermittent access total locomotion	1.8	2.1	6.6	-1.2	-0.6	2.6	-1.1	-1.0	1.4
Intermittent access standard deviation	0.1	0.5	1.6	-0.4	-0.2	0.3	-1.3	-0.9	0.4
Left kidney weight	0.1	0.6	1.0	-0.5	-0.4	1.0	-0.6	-0.9	0.9
Right kidney weight	0.1	0.4	1.6	-0.4	-0.8	1.3	-0.4	-0.4	0.1
Cocaine induced anxiety	0.6	1.6	3.4	1.7	1.2	-1.8	-0.7	-0.6	0.8
Post-drug Anxiety	0.5	0.5	2.0	0.8	0.4	-1.4	0.4	0.4	-0.2
Baseline Anxiety	0.9	1.5	2.4	-1.2	-1.3	0.7	1.0	1.5	-1.4
Tail length	1.9	10.3	21.2	0.3	0.4	2.5	-4.3	-4.0	4.6
Length with tail	1.9	8.6	18.8	1.0	1.0	1.5	-4.3	-4.1	3.3
Length without tail	0.1	0.7	1.8	0.7	0.4	-0.0	-1.3	-1.3	-0.4
Times rat made contact with spout	0.5	0.6	2.0	-0.7	-0.9	1.4	-0.5	0.1	0.4
Lifetime Intake	0.9	1.2	3.8	-0.9	-0.2	2.0	-0.9	-0.6	1.0
Liver weight, left	1.3	2.2	3.4	1.2	1.2	1.1	-1.7	-1.8	1.6
Liver weight, right	0.2	0.4	0.9	-0.8	-1.0	0.9	-0.3	0.0	-0.2
Locomotor activity	0.7	1.1	3.5	-0.8	0.2	1.9	-1.0	-0.3	1.2
Locomotor testing distance	0.9	2.3	7.5	-1.6	-0.4	2.7	-1.1	-0.5	1.4
Locomotor testing rearing	1.3	4.9	13.7	-2.4	-1.6	3.7	-2.0	-0.8	1.6
Locomotion in novel chamber	0.6	0.8	2.2	1.0	1.0	-1.5	-0.5	-0.7	-0.4
Locomotion in novel chamber post-restriction	0.4	1.1	3.8	-0.3	-0.6	0.2	1.0	1.1	-2.0
Fecal boli incidents, locomotor time 1	0.3	0.8	1.5	1.0	0.8	-1.0	1.2	-0.0	-0.7
Change in fecal boli incidents, locomotor task	0.5	0.5	1.3	-0.5	-0.6	-0.6	0.2	0.9	-1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.3	0.2	0.1	0.2	0.4	-0.5
Bouts of movement, locomotor time 1	0.5	0.7	1.1	-0.6	-1.1	1.1	-1.1	-0.4	0.4
Total resting periods, locomotor time 1	0.2	0.3	0.8	-0.1	-0.7	0.5	-0.9	-0.4	0.2
Rest time, locomotor task time 1	0.2	0.4	1.2	0.3	0.1	-1.1	-0.6	0.7	-0.3
Distance moved, locomotor task time 1	0.2	0.7	1.5	-1.1	-1.0	1.2	0.4	-0.0	-0.3
Vertical activity count, locomotor time 1	0.1	0.6	1.7	-0.9	-1.0	1.3	-0.0	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.3	0.9	2.1	-1.5	-1.2	0.1	-0.4	1.1	-0.6
Bouts of movement, locomotor time 2	0.5	1.7	3.4	-1.8	-1.7	1.7	-0.3	0.3	-1.0
Total resting periods, locomotor time 2	0.4	1.8	3.3	-1.8	-1.6	1.7	-0.1	0.4	-1.3
Rest time, locomotor task time 2	0.9	1.5	4.2	1.4	1.0	-2.1	0.5	0.5	-1.3
Distance moved, locomotor task time 2	1.5	1.9	4.7	-2.0	-2.2	1.4	0.3	1.0	-0.3
Vertical activity count, locomotor time 2	0.8	1.8	4.8	-1.6	-1.8	2.2	0.1	0.4	0.4
Light reinforcement 1	0.9	4.3	6.6	-2.6	-1.8	1.9	2.4	2.3	-1.1
Light reinforcement 2	0.1	0.2	0.8	0.1	0.9	-0.3	0.1	-0.0	0.2
Bone: marrow area	14.4	35.2	56.1	7.2	7.5	-3.6	-6.0	-5.4	5.1
Bone: maximum diameter	3.6	7.2	16.7	3.4	4.1	-1.3	-2.1	-2.3	1.9
Bone: maximum force	1.1	2.1	4.3	1.7	2.1	0.2	-1.4	-1.7	0.8
Bone: maximum moment	1.1	2.1	3.8	1.6	1.9	0.2	-1.5	-1.7	0.9
Mean time between licks in bursts	0.2	1.2	2.2	0.7	0.9	-1.2	-1.5	-1.0	1.0
Mean num. licks in bursts	0.6	1.6	2.8	-1.4	-1.4	1.7	1.2	0.4	-1.0
Cd content in liver	0.6	0.6	2.0	0.1	-0.4	-1.0	0.6	0.6	-1.4
Co content in liver	0.3	0.3	1.6	0.4	-0.1	-1.2	-0.3	-0.0	0.1
Cu content in liver	0.4	0.5	1.1	1.0	0.9	-0.7	-0.4	-0.4	0.2
Fe content in liver	0.2	0.2	0.6	0.0	0.3	-0.7	0.1	-0.1	0.7
K content in liver	0.2	0.2	0.5	0.7	0.3	0.1	0.6	-0.0	-0.7
Mg content in liver	1.0	1.1	2.6	0.5	-0.1	-0.4	1.6	1.1	-1.6
Mn content in liver	2.5	2.8	7.5	-0.3	-0.4	-0.2	2.7	2.3	-2.0
Na content in liver	0.8	0.9	2.4	-0.1	-0.4	-0.4	1.4	0.7	-1.6
Rb content in liver	0.5	0.6	1.1	-0.2	-0.6	-0.8	0.8	1.0	-1.1
Se content in liver	0.4	0.5	1.1	-0.6	-0.1	0.4	1.1	0.8	-0.7
Sr content in liver	0.1	0.1	0.3	-0.0	0.2	-0.0	-0.5	-0.3	0.3
Zn content in liver	0.7	0.8	2.2	1.3	1.5	-0.5	-0.4	-0.5	0.4
Bone: minimum diameter	9.5	18.3	31.5	4.8	5.6	-0.9	-4.5	-4.2	4.0
Time in familiar zone, hab. session 1	0.3	0.3	0.6	0.8	0.7	-0.7	0.0	-0.4	-0.3
Time in novel zone, hab. session 1	0.5	0.6	1.4	-0.9	-0.9	1.2	0.3	0.3	0.2
Total zone transitions, hab. session 1	0.6	0.8	2.1	-1.2	-1.0	1.4	0.2	-0.5	0.0
Total locomotion distance, hab. session 1	1.4	2.0	4.2	-2.0	-1.8	2.0	0.6	0.5	-0.3
Locomotion velocity, hab. session 1	0.9	1.2	2.7	-1.6	-1.4	1.5	0.3	0.5	0.1
Time in familiar zone, hab. session 2	1.4	1.6	2.9	1.0	1.2	-0.3	-1.6	-1.3	1.7
Time in novel zone, hab. session 2	2.6	2.9	6.0	-0.8	-1.1	0.1	2.4	2.0	-2.3
Total zone transitions, hab. session 2	0.3	0.4	1.4	-1.2	-0.4	0.7	0.4	0.1	-0.1
Total locomotion distance, hab. session 2	2.2	2.9	6.3	-2.5	-1.8	1.5	1.4	1.5	-1.0
Locomotion velocity, hab. session 2	2.1	2.8	5.9	-2.4	-1.8	1.4	1.5	1.6	-1.1
Novel to familiar place preference ratio	2.7	3.6	7.3	1.1	1.4	0.8	-2.5	-2.7	1.9
Novelty place preference	2.3	2.9	6.3	1.1	1.3	0.5	-2.3	-2.5	1.7
Time in novel zone, NPP test	2.0	2.5	5.2	0.9	1.2	0.6	-2.1	-2.3	1.6
Total zone transitions, NPP test	1.8	2.7	5.0	-2.2	-1.4	2.0	1.6	1.2	-1.2
Total locomotion distance, NPP test	4.0	5.6	8.4	-2.9	-2.6	2.5	2.2	2.1	-1.7
Locomotion velocity, NPP test	4.0	5.7	9.6	-3.1	-2.6	2.8	2.1	1.8	-1.7
Intraocular pressure	2.2	3.5	9.1	0.2	1.5	1.0	-2.2	-2.1	3.0
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.6	-0.3	0.3	0.3	0.7	0.2
Delta ambulatory time before/after self-admin	0.1	0.1	0.5	0.1	0.1	-0.1	0.2	0.7	-0.2
Parametrial fat weight	0.8	1.9	4.9	1.7	1.1	-2.2	0.6	1.1	-1.1
Pavlov. Cond. lever latency	0.9	1.1	2.3	0.7	0.5	-1.2	1.5	0.7	-1.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.2	-0.5	0.1	-0.0	-0.1	0.5
Pavlov. Cond. change in total contacts	1.0	1.0	2.4	-0.1	-0.2	0.7	-1.3	-1.3	1.5
Pavlov. Cond. index score	0.3	0.4	1.0	-0.1	-0.3	0.5	-0.9	-0.6	1.0
Pavlov. Cond. latency score	0.4	0.5	1.1	-0.2	-0.4	0.7	-0.9	-0.6	1.0
Pavlov. Cond. lever contacts	0.5	0.6	1.1	-0.5	-0.5	0.9	-1.0	-0.5	1.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.1	0.3	0.1	0.2	0.3	-0.4
Pavlov. Cond. intertrial magazine entries	4.4	5.3	9.0	0.9	2.2	1.2	-3.0	-2.7	3.0
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.8	-0.1	-0.3	0.5	-0.6	-0.4	0.9
Pavlov. Cond. response bias	0.2	0.2	0.6	0.2	-0.2	0.1	-0.6	-0.4	0.8
Pavlov. Cond. lever latency	0.3	0.4	1.7	-0.2	-0.7	-1.3	0.1	0.2	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	0.2	0.7	-1.0	0.0	-0.4	0.4
Pavlov. Cond. change in total contacts	0.2	0.5	1.3	0.4	1.1	0.3	-0.2	-0.5	1.1
Pavlov. Cond. index score	0.5	0.8	2.1	0.8	1.4	-0.0	-0.4	-0.8	1.2
Pavlov. Cond. latency score	0.5	0.8	2.1	0.7	1.4	-0.0	-0.4	-0.8	1.2
Pavlov. Cond. lever contacts	0.2	0.3	1.6	-0.0	0.4	1.3	0.4	0.2	0.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.2	-0.6	0.6	-0.1	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.5	0.7	0.5	0.5	0.2	0.6	-0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.9	0.7	1.4	-0.1	-0.3	-0.8	1.1
Pavlov. Cond. response bias	0.2	0.2	0.6	0.3	0.7	0.7	0.2	-0.1	0.3
Time in closed arm before self-admin	0.4	0.7	3.0	-0.8	-0.2	0.6	0.1	0.1	1.7
Time in closed arm after self-admin	0.3	0.3	1.3	-0.3	-0.1	0.0	-0.8	-0.1	1.1
Time in open arm before self-admin	0.1	0.2	0.3	-0.4	-0.4	-0.4	-0.4	-0.3	-0.5
Time in open arm after self-admin	0.1	0.2	0.6	0.0	0.6	0.0	-0.1	-0.8	-0.3
Bone: periosteal estimation	7.2	17.1	28.6	4.7	5.3	-1.2	-4.3	-4.2	3.8
Bone: periosteal perimeter	5.5	10.8	18.7	3.5	4.3	-1.0	-3.3	-3.5	3.0
Bone: post-yield work	1.9	3.3	6.0	2.2	2.4	-0.3	-1.9	-2.0	1.0
Progressive ratio test 1 active lever presses	1.7	3.0	8.6	-2.0	-1.5	2.9	-1.1	-0.7	1.3
Progressive ratio test 1 breakpoint	1.6	2.7	7.8	-1.8	-1.3	2.8	-1.1	-0.6	1.3
Progressive ratio test 1 inactive lever presses	0.9	2.3	7.4	-1.8	-1.6	2.7	-0.5	-0.4	-0.4
Progressive ratio test 2 active lever presses	0.9	1.3	2.2	-1.0	-0.5	1.4	-1.5	-1.0	1.3
Progressive ratio test 2 breakpoint	1.0	1.3	2.2	-1.0	-0.5	1.4	-1.5	-1.0	1.3
Progressive ratio test 2 inactive lever presses	0.3	1.0	2.5	-0.6	-0.4	1.6	-1.3	-0.9	0.5
Incentive Sensitization - Responses	0.2	0.5	1.6	0.1	0.4	0.4	-1.0	-1.3	0.6
Incentive Sensitization - Breakpoint	0.2	0.5	1.5	0.1	0.4	0.3	-1.1	-1.2	0.5
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.5	-0.7	-0.5	0.2	-0.6	0.4	0.1
Progressive ratio	0.9	2.5	5.0	1.7	2.2	-2.0	-1.1	-1.4	0.5
Food seeking constrained by brief footshock	0.9	1.1	1.9	1.1	0.8	-0.8	-1.4	-1.4	0.7
Seeking ratio, punishment vs. effort	0.4	1.0	2.6	-1.0	-1.4	1.6	0.0	0.2	0.3
Retroperitoneal fat weight	0.4	1.9	2.9	-1.3	-1.7	1.5	-1.6	-1.2	0.7
Reaction time number correct	0.1	0.5	1.1	0.6	1.1	-0.6	0.5	0.7	-0.4
Reaction time mean minus median	0.1	0.9	2.7	1.0	0.3	-1.6	0.2	1.1	-0.6
Reaction time mean minus median AUC	0.2	1.3	2.3	1.1	0.7	-1.3	0.9	1.5	-1.0
Reaction time num false alarms	1.0	1.7	3.9	0.8	2.0	0.6	-1.0	-1.4	1.5
Reaction time num false alarms AUC	0.6	1.4	5.0	1.2	2.2	0.1	-0.4	-1.0	1.0
Reaction time trials correct on left	0.1	0.5	1.1	0.6	1.1	-0.6	0.5	0.7	-0.4
Reaction time trials on left	0.2	0.6	1.2	0.7	1.1	-0.7	0.6	0.8	-0.5
Reaction time mean	0.3	0.6	1.5	0.4	-0.5	-1.2	0.7	0.9	-0.4
Reaction time mean AUC	0.2	0.5	1.1	0.2	-0.6	-1.0	0.7	0.9	-0.4
Median of all reaction times	0.3	0.5	1.3	0.2	-0.7	-1.1	0.9	0.8	-0.3
Reaction time omissions	1.2	2.0	4.5	0.9	0.1	-1.4	1.6	2.1	-1.5
Reaction time false alarm rate	0.7	1.0	1.8	0.6	1.3	0.5	-0.7	-1.3	1.2
Reaction time premature initiation rate	0.6	1.0	2.8	-0.9	-0.9	1.7	-0.5	-1.1	0.1
Reaction time premature initiations	0.1	0.3	1.2	-0.4	-0.1	1.1	0.1	-0.5	-0.3
Std. dev. reaction times	0.4	1.3	2.4	0.9	-0.1	-1.5	1.1	1.4	-1.3
Reaction time trials completed	0.2	0.6	1.2	0.7	1.1	-0.7	0.6	0.8	-0.5
Reaction time trials AUC	0.1	0.5	0.9	0.6	1.0	-0.6	0.5	0.8	-0.6
Run reversals in cocaine runway, females	0.5	0.5	1.3	-0.7	-1.2	-0.7	-0.7	-0.6	-0.2
Run reversals in cocaine runway, males	1.9	2.1	4.3	1.5	1.0	-0.9	-1.6	-2.1	1.2
Latency to leave start box in cocaine runway	2.1	2.9	6.1	-2.5	-2.1	1.7	0.9	1.7	-0.3
Latency to leave start box in cocaine runway, F	2.9	3.6	8.0	-2.8	-2.5	2.7	0.4	0.5	-0.1
Latency to leave start box in cocaine runway, M	1.8	1.7	6.0	-1.0	-0.8	-0.6	1.4	2.5	-0.7
Std. dev. time between licks in bursts	0.5	0.9	1.6	-1.1	-1.3	0.1	0.3	1.1	-1.0
Total sessions with >9 infusions	1.8	2.3	7.5	-2.1	-1.2	2.7	-0.7	-0.3	0.2
Short access day 1 total inactive lever presses	0.6	1.2	4.5	-0.8	-0.4	2.1	-1.0	-0.8	0.3
Short access day 10 total inactive lever presses	0.1	0.4	1.1	1.0	0.8	-0.7	-0.5	-0.2	-0.3
Short access day 1 total infusions	1.1	2.2	8.0	-2.0	-0.8	2.8	-0.5	-0.3	0.5
Short access day 10 total infusions	1.7	2.8	12.1	-1.8	-0.9	3.5	-0.6	-0.5	0.1
Short access total infusions	1.1	1.5	6.0	-1.2	-0.3	2.4	-0.7	-0.6	0.7
Short access day 1 locomotion	2.9	4.8	15.9	-2.5	-1.7	4.0	-1.2	-1.3	0.9
Short access day 10 total locomotion	0.3	1.1	2.7	-0.1	0.3	0.9	-1.4	-1.0	1.6
Short access total locomotion	1.7	2.5	8.1	-1.9	-1.2	2.9	-1.1	-0.8	0.6
One hour access (0.3 mA shock)	0.3	0.4	1.3	-0.1	0.3	1.1	-0.4	-0.7	0.5
Compulsive drug intake	0.4	0.6	1.7	1.3	0.9	0.3	-0.1	-1.1	0.4
One hour access (shock baseline)	0.0	0.1	0.2	-0.4	0.0	0.1	-0.4	0.3	0.1
Social response proportion	0.7	0.9	2.7	1.7	1.2	-0.7	-0.2	-0.0	-0.7
Social responses	1.1	1.5	2.7	-0.6	-0.6	1.3	1.7	1.2	-1.5
Social time	1.1	1.7	3.8	1.9	1.8	-1.7	0.1	-0.2	-0.2
Soleus weight	1.0	3.1	6.5	2.0	2.5	-1.3	-1.8	-1.1	1.4
Bone: stiffness	0.7	1.3	3.1	1.7	1.6	-0.4	-0.9	-1.2	-0.1
Tibialis anterior weight	0.5	1.6	3.5	0.8	1.1	-1.1	-1.3	-1.1	1.9
Time to tail flick, vehicle, before self-admin	0.3	0.4	1.0	0.9	0.1	-0.6	0.0	-1.0	-0.1
Time to tail flick, vehicle, after self-admin	0.7	1.4	2.3	1.3	1.5	-1.4	-1.3	-0.7	0.1
Time to tail flick, test, before self-admin	3.1	3.6	5.4	2.1	1.5	-0.6	-2.2	-2.3	2.0
Time to tail flick, test, after self-admin	0.4	0.5	1.3	0.5	0.0	1.2	-0.7	-0.5	-0.7
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	1.4	0.2	0.2	0.1	0.4	0.5	-1.2
Delta time to tail flick, test, before/after SA	0.3	0.3	1.5	-0.3	-0.2	0.5	0.2	0.5	-1.2
Tibia length	1.0	2.8	6.6	0.2	0.3	0.0	-2.1	-2.6	2.3
Ambulatory time before self-admin	0.1	0.3	0.5	-0.7	-0.6	-0.5	0.4	0.2	-0.5
Ambulatory time after self-admin	0.2	0.2	0.5	-0.4	-0.4	-0.7	0.4	0.6	-0.4
Bone: tissue strength	2.6	2.7	3.7	-1.8	-1.5	0.9	1.9	1.6	-1.9
Total heroin consumption	0.5	0.6	1.5	0.5	0.2	-0.8	0.7	1.2	-0.8
Bone: trabecular number	1.1	2.0	3.3	1.8	1.3	-1.6	1.6	1.0	-1.1
Bone: trabecular spacing	1.0	1.4	2.6	-1.6	-1.4	1.3	-1.2	-0.6	0.6
Bone: trabecular thickness	1.0	1.4	4.0	1.9	2.0	-0.4	-0.4	-0.6	0.6
Bone: trabecular tissue density	0.6	1.1	2.2	-1.3	-1.5	0.3	0.5	1.2	-0.8
Water consumed over 24 hours	2.5	4.9	8.4	-2.2	-2.2	1.3	2.2	2.9	-2.2
Number of responses in last shaping day	0.6	0.7	2.2	-1.5	-1.2	0.8	-0.0	-0.1	-0.0