Hub : Traits : Locomotion velocity, hab. session 1 : →

chr1:140,614,300-142,727,457

Trait: Locomotion velocity, hab. session 1

Best TWAS P=9.343225e-14 · Best GWAS P=7.101521e-14 conditioned to 0.05259487

Associated models

#	Tissue	Gene	Modality	RNA phenotype	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	Adipose	Ctsc	alternative polyA	ENSRNOT00000022342	0.16	0.14	blup	2515	0.17	2.8e-18	4.4	5.6	2.1e-08	-0.84	1.00	0.00	FALSE
2	Adipose	Ctsc	alternative polyA	ENSRNOT00000097085	0.17	0.13	blup	2515	0.19	1.5e-20	4.1	-5.8	7.0e-09	0.86	0.98	0.02	FALSE
3	Adipose	Ctsc	isoform ratio	ENSRNOT00000022342	0.16	0.10	blup	2515	0.16	4.3e-17	4.4	5.8	5.2e-09	-0.87	0.82	0.18	FALSE
4	Adipose	Ctsc	isoform ratio	ENSRNOT00000097085	0.18	0.11	blup	2515	0.18	1.3e-19	-6.6	-6.0	2.2e-09	0.88	0.62	0.38	FALSE
5	Adipose	Ctsc	intron excision ratio	chr1:142031177:142036233	0.05	0.03	blup	2515	0.04	6.5e-05	-6.9	-6.2	6.1e-10	0.90	0.40	0.60	FALSE
6	Adipose	Ctsc	intron excision ratio	chr1:142031177:142045569	0.04	0.01	blup	2515	0.02	4.7e-03	-6.9	5.9	3.8e-09	-0.87	0.48	0.50	FALSE
7	BLA	Ctsc	alternative polyA	ENSRNOT00000022342	0.07	0.00	blup	2518	0.01	5.1e-02	-5.6	5.5	2.9e-08	-0.72	0.46	0.19	FALSE
8	BLA	Ctsc	alternative polyA	ENSRNOT00000097085	0.07	0.00	blup	2518	0.02	3.2e-02	2.4	-5.3	1.1e-07	0.68	0.46	0.17	FALSE
9	BLA	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.10	top1	1	0.10	5.0e-06	-6.1	-6.1	1.2e-09	0.93	0.34	0.03	FALSE
10	BLA	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.03	top1	1	0.03	1.5e-02	-7.3	7.3	2.8e-13	-0.88	0.09	0.10	FALSE
11	Brain	Grm5	gene expression	ENSRNOG00000016429	0.16	0.10	lasso	6	0.15	5.3e-14	-6.7	6.1	9.1e-10	-0.84	0.39	0.61	FALSE
12	Brain	Ctsc	gene expression	ENSRNOG00000016496	0.23	0.27	blup	2518	0.31	4.5e-29	4.1	-5.5	2.9e-08	0.82	1.00	0.00	FALSE
13	Brain	Ctsc	isoform ratio	ENSRNOT00000022342	0.03	0.04	top1	1	0.04	1.7e-04	-7.4	7.4	9.3e-14	-0.88	0.03	0.74	TRUE
14	Eye	Ctsc	gene expression	ENSRNOG00000016496	0.29	0.15	top1	1	0.15	2.9e-03	-6.5	-6.5	8.6e-11	0.91	0.14	0.06	FALSE
15	IL	Ctsc	gene expression	ENSRNOG00000016496	0.30	0.16	top1	1	0.16	1.0e-04	-6.8	-6.8	1.3e-11	0.91	0.13	0.06	FALSE
16	Liver	Ctsc	mRNA stability	ENSRNOG00000016496	0.05	0.04	blup	2515	0.04	1.8e-05	4.1	5.3	1.1e-07	-0.80	0.98	0.01	FALSE
17	NAcc	Ctsc	gene expression	ENSRNOG00000016496	0.12	0.09	blup	2516	0.12	3.3e-09	-6.5	-6.3	2.7e-10	0.91	0.57	0.43	FALSE
18	NAcc	Grm5	mRNA stability	ENSRNOG00000016429	0.07	0.02	blup	2630	0.04	1.0e-03	4.0	-5.1	2.9e-07	0.69	0.82	0.12	FALSE
19	OFC	Grm5	mRNA stability	ENSRNOG00000016429	0.17	0.05	blup	2628	0.08	6.5e-03	4.3	-5.3	1.5e-07	0.71	0.47	0.21	FALSE
20	PL	Ctsc	gene expression	ENSRNOG00000016496	0.14	0.11	enet	87	0.13	8.2e-10	-6.9	-5.7	1.0e-08	0.75	0.34	0.66	FALSE
21	PL	Grm5	mRNA stability	ENSRNOG00000016429	0.04	0.03	top1	1	0.03	1.3e-03	-7.3	-7.3	3.0e-13	0.93	0.09	0.04	FALSE

h2: Heritability estimate for the given transcriptomic model. PP3: Posterior probability of two distinct causal variants. PP4: Posterior probability of a single shared causal variant. joint: Whether the RNA phenotype is in the joint model.