chr1:140,614,300-142,727,457

Trait: Locomotion velocity, hab. session 1

Best TWAS P= 9.34e-14 · Best GWAS P=7.10e-14 conditioned to 5.26e-02

Associated models

Tissue Gene RNA modality RNA phenotype h2 # weights Model R2 Model R2 P TWAS Z TWAS P Coloc P Joint
Adipose Ctsc alternative polyA ENSRNOT00000022342 0.16 2515 0.17 2.8e-18 5.61 2.06e-08 0 FALSE
Adipose Ctsc alternative polyA ENSRNOT00000097085 0.17 2515 0.19 1.5e-20 -5.79 7.03e-09 0.02 FALSE
Adipose Ctsc isoform ratio ENSRNOT00000022342 0.16 2515 0.16 4.3e-17 5.84 5.15e-09 0.18 FALSE
Adipose Ctsc isoform ratio ENSRNOT00000097085 0.18 2515 0.18 1.3e-19 -5.98 2.23e-09 0.38 FALSE
Adipose Ctsc intron excision ratio chr1:142031177:142036233 0.05 2515 0.04 6.5e-05 -6.19 6.08e-10 0.6 FALSE
Adipose Ctsc intron excision ratio chr1:142031177:142045569 0.04 2515 0.02 4.7e-03 5.89 3.80e-09 0.5 FALSE
BLA Ctsc alternative polyA ENSRNOT00000022342 0.07 2518 0.01 5.1e-02 5.55 2.92e-08 0.19 FALSE
BLA Ctsc alternative polyA ENSRNOT00000097085 0.07 2518 0.02 3.2e-02 -5.32 1.06e-07 0.17 FALSE
BLA Ctsc gene expression ENSRNOG00000016496 0.12 1 0.1 5.0e-06 -6.08 1.21e-09 0.03 FALSE
BLA Ctsc mRNA stability ENSRNOG00000016496 0.05 1 0.03 1.5e-02 7.3 2.84e-13 0.1 FALSE
Brain Grm5 gene expression ENSRNOG00000016429 0.16 6 0.15 5.3e-14 6.12 9.15e-10 0.61 FALSE
Brain Ctsc gene expression ENSRNOG00000016496 0.23 2518 0.31 4.5e-29 -5.55 2.92e-08 0 FALSE
Brain Ctsc isoform ratio ENSRNOT00000022342 0.03 1 0.04 1.7e-04 7.45 9.34e-14 0.74 TRUE
Eye Ctsc gene expression ENSRNOG00000016496 0.29 1 0.15 2.9e-03 -6.49 8.61e-11 0.06 FALSE
IL Ctsc gene expression ENSRNOG00000016496 0.3 1 0.16 1.0e-04 -6.77 1.31e-11 0.06 FALSE
Liver Ctsc mRNA stability ENSRNOG00000016496 0.05 2515 0.04 1.8e-05 5.31 1.11e-07 0.01 FALSE
NAcc Ctsc gene expression ENSRNOG00000016496 0.12 2516 0.12 3.3e-09 -6.32 2.66e-10 0.43 FALSE
NAcc Grm5 mRNA stability ENSRNOG00000016429 0.07 2630 0.04 1.0e-03 -5.13 2.86e-07 0.12 FALSE
OFC Grm5 mRNA stability ENSRNOG00000016429 0.17 2628 0.08 6.5e-03 -5.25 1.48e-07 0.21 FALSE
PL Ctsc gene expression ENSRNOG00000016496 0.14 87 0.13 8.2e-10 -5.73 1.03e-08 0.66 FALSE
PL Grm5 mRNA stability ENSRNOG00000016429 0.04 1 0.03 1.3e-03 -7.29 3.02e-13 0.04 FALSE