Hub : Traits : Locomotion velocity, hab. session 1 : →

chr1:140,610,199-142,727,457

Trait: Locomotion velocity, hab. session 1

Best TWAS P=9.34e-14 · Best GWAS P=7.10e-14 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	isoform ratio	NM_017097.2	0.18	2521	0.16	5.6e-17	5.49	3.92e-08	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.3	0.19	2521	0.16	1.2e-17	-5.44	5.45e-08	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_142031177_142036233	0.05	2521	0.02	1.1e-03	-6.29	3.18e-10	0.64	FALSE
Adipose	Ctsc	intron excision ratio	chr1_142031177_142045569	0.04	2521	0.03	4.0e-04	6.08	1.23e-09	0.6	FALSE
BLA	Ctsc	gene expression	Ctsc	0.1	1	0.08	7.2e-05	7.45	9.34e-14	0.84	TRUE
BLA	Ctsc	isoform ratio	XM_008759637.3	0.05	1	0.03	1.2e-02	6.19	6.20e-10	0.04	FALSE
BLA	Grm5	isoform ratio	XM_017588780.2	0.06	2702	0.01	6.6e-02	6.84	7.90e-12	0.58	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	1	0.07	5.1e-07	-6.19	6.20e-10	0.01	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.3	0.06	1	0.07	2.3e-07	6.69	2.23e-11	0.22	FALSE
Brain	Grm5	gene expression	Grm5	0.55	26	0.32	1.9e-30	-6.38	1.73e-10	0.48	FALSE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.06	4.1e-06	-6.76	1.40e-11	0.26	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.3	0.06	1	0.06	1.2e-06	6.76	1.40e-11	0.29	FALSE
Brain	Grm5	isoform ratio	XM_017588780.2	0.05	93	0.04	2.2e-04	-6.7	2.03e-11	0.52	FALSE
Brain	Grm5	mRNA stability	Grm5	0.11	1	0.09	4.7e-09	-6.61	3.75e-11	0.01	TRUE
Eye	Ctsc	gene expression	Ctsc	0.37	2521	0.14	3.3e-03	-6.69	2.27e-11	0.18	FALSE
IL	Ctsc	gene expression	Ctsc	0.48	10	0.14	2.9e-04	-6.87	6.43e-12	0.64	FALSE
Liver	LOC102554680	gene expression	LOC102554680	0.04	2516	0.03	5.3e-04	-6.69	2.24e-11	0.64	FALSE
NAcc	Ctsc	gene expression	Ctsc	0.14	2521	0.16	1.5e-18	-6.17	6.85e-10	0.51	FALSE
NAcc	Grm5	gene expression	Grm5	0.05	1	0.05	1.4e-06	-6.91	4.79e-12	0.07	FALSE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.03	1	0.04	2.3e-05	-6.41	1.41e-10	0.03	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.3	0.03	1	0.04	5.3e-05	6.41	1.41e-10	0.03	FALSE
NAcc	Grm5	isoform ratio	XM_017588779.2	0.05	2702	0.05	4.8e-06	-6.29	3.10e-10	0.57	FALSE
NAcc	Grm5	isoform ratio	XM_017588780.2	0.04	2702	0.03	1.1e-04	6.65	2.96e-11	0.71	FALSE
OFC	Grm5	gene expression	Grm5	0.29	2702	0.25	1.4e-06	5.54	2.99e-08	0.19	FALSE
PL	Ctsc	gene expression	Ctsc	0.2	2521	0.2	7.0e-22	-5.81	6.16e-09	0.11	FALSE
PL	Grm5	gene expression	Grm5	0.03	23	0.03	1.2e-04	6.95	3.69e-12	0.19	TRUE
PL	Grm5	isoform ratio	XM_006229659.4	0.02	2702	0.01	5.9e-02	-5.87	4.35e-09	0.21	FALSE
pVTA	Ctsc	gene expression	Ctsc	0.24	11	0.21	1.1e-09	5.6	2.13e-08	0.02	FALSE