Best TWAS P= 9.34e-14 · Best GWAS P=7.10e-14 conditioned to 5.26e-02
Tissue | Gene | RNA modality | RNA phenotype | h2 | # weights | Model R2 | Model R2 P | TWAS Z | TWAS P | Coloc P | Joint |
---|---|---|---|---|---|---|---|---|---|---|---|
Adipose | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.16 | 2515 | 0.17 | 2.8e-18 | 5.61 | 2.06e-08 | 0 | FALSE |
Adipose | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.17 | 2515 | 0.19 | 1.5e-20 | -5.79 | 7.03e-09 | 0.02 | FALSE |
Adipose | Ctsc | isoform ratio | ENSRNOT00000022342 | 0.16 | 2515 | 0.16 | 4.3e-17 | 5.84 | 5.15e-09 | 0.18 | FALSE |
Adipose | Ctsc | isoform ratio | ENSRNOT00000097085 | 0.18 | 2515 | 0.18 | 1.3e-19 | -5.98 | 2.23e-09 | 0.38 | FALSE |
Adipose | Ctsc | intron excision ratio | chr1:142031177:142036233 | 0.05 | 2515 | 0.04 | 6.5e-05 | -6.19 | 6.08e-10 | 0.6 | FALSE |
Adipose | Ctsc | intron excision ratio | chr1:142031177:142045569 | 0.04 | 2515 | 0.02 | 4.7e-03 | 5.89 | 3.80e-09 | 0.5 | FALSE |
BLA | Ctsc | alternative polyA | ENSRNOT00000022342 | 0.07 | 2518 | 0.01 | 5.1e-02 | 5.55 | 2.92e-08 | 0.19 | FALSE |
BLA | Ctsc | alternative polyA | ENSRNOT00000097085 | 0.07 | 2518 | 0.02 | 3.2e-02 | -5.32 | 1.06e-07 | 0.17 | FALSE |
BLA | Ctsc | gene expression | ENSRNOG00000016496 | 0.12 | 1 | 0.1 | 5.0e-06 | -6.08 | 1.21e-09 | 0.03 | FALSE |
BLA | Ctsc | mRNA stability | ENSRNOG00000016496 | 0.05 | 1 | 0.03 | 1.5e-02 | 7.3 | 2.84e-13 | 0.1 | FALSE |
Brain | Grm5 | gene expression | ENSRNOG00000016429 | 0.16 | 6 | 0.15 | 5.3e-14 | 6.12 | 9.15e-10 | 0.61 | FALSE |
Brain | Ctsc | gene expression | ENSRNOG00000016496 | 0.23 | 2518 | 0.31 | 4.5e-29 | -5.55 | 2.92e-08 | 0 | FALSE |
Brain | Ctsc | isoform ratio | ENSRNOT00000022342 | 0.03 | 1 | 0.04 | 1.7e-04 | 7.45 | 9.34e-14 | 0.74 | TRUE |
Eye | Ctsc | gene expression | ENSRNOG00000016496 | 0.29 | 1 | 0.15 | 2.9e-03 | -6.49 | 8.61e-11 | 0.06 | FALSE |
IL | Ctsc | gene expression | ENSRNOG00000016496 | 0.3 | 1 | 0.16 | 1.0e-04 | -6.77 | 1.31e-11 | 0.06 | FALSE |
Liver | Ctsc | mRNA stability | ENSRNOG00000016496 | 0.05 | 2515 | 0.04 | 1.8e-05 | 5.31 | 1.11e-07 | 0.01 | FALSE |
NAcc | Ctsc | gene expression | ENSRNOG00000016496 | 0.12 | 2516 | 0.12 | 3.3e-09 | -6.32 | 2.66e-10 | 0.43 | FALSE |
NAcc | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.07 | 2630 | 0.04 | 1.0e-03 | -5.13 | 2.86e-07 | 0.12 | FALSE |
OFC | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.17 | 2628 | 0.08 | 6.5e-03 | -5.25 | 1.48e-07 | 0.21 | FALSE |
PL | Ctsc | gene expression | ENSRNOG00000016496 | 0.14 | 87 | 0.13 | 8.2e-10 | -5.73 | 1.03e-08 | 0.66 | FALSE |
PL | Grm5 | mRNA stability | ENSRNOG00000016429 | 0.04 | 1 | 0.03 | 1.3e-03 | -7.29 | 3.02e-13 | 0.04 | FALSE |