Hub : Traits : Locomotion velocity, hab. session 1 : →

chr1:149,923,636-152,140,050

Trait: Locomotion velocity, hab. session 1

Best TWAS P = 2.26e-13 · Best GWAS P= 3.80e-14 conditioned to 1.00e+00

Associated models

Tissue	Gene	RNA modality	RNA phenotype	h2	# weights	Model R2	Model R2 P	TWAS Z	TWAS P	Coloc P	Joint
Adipose	Ctsc	alternative polyA	NM_017097.2	0.18	2571	0.19	1.5e-20	5.32	1.06e-07	0	FALSE
Adipose	Ctsc	alternative polyA	XM_008759637.4	0.19	2571	0.2	1.0e-21	-5.25	1.54e-07	0	FALSE
Adipose	Ctsc	isoform ratio	NM_017097.2	0.17	2571	0.16	1.9e-17	5.57	2.59e-08	0	FALSE
Adipose	Ctsc	isoform ratio	XM_008759637.4	0.17	2571	0.17	3.0e-18	-5.54	3.00e-08	0	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151448822	0.05	2571	0.03	7.1e-04	-6.25	4.10e-10	0.63	FALSE
Adipose	Ctsc	intron excision ratio	chr1_151443766_151458158	0.04	2571	0.03	4.0e-04	5.98	2.24e-09	0.57	FALSE
BLA	Ctsc	gene expression	Ctsc	0.15	281	0.12	7.5e-07	5.39	7.24e-08	0.67	FALSE
BLA	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.03	1.8e-02	-6.18	6.27e-10	0.04	FALSE
BLA	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.02	1.8e-02	6.18	6.27e-10	0.04	FALSE
Brain	Ctsc	alternative polyA	NM_017097.2	0.06	24	0.07	6.8e-07	-6.71	2.00e-11	0.63	FALSE
Brain	Ctsc	alternative polyA	XM_008759637.4	0.06	24	0.07	7.0e-07	6.71	1.92e-11	0.62	FALSE
Brain	Ctsc	gene expression	Ctsc	0.28	2571	0.37	1.3e-36	-5.24	1.60e-07	0	FALSE
Brain	Grm5	gene expression	Grm5	0.46	13	0.3	2.7e-28	6.84	8.14e-12	0.48	FALSE
Brain	Ctsc	isoform ratio	NM_017097.2	0.06	1	0.05	2.1e-05	-6.72	1.79e-11	0.19	FALSE
Brain	Ctsc	isoform ratio	XM_008759637.4	0.06	1	0.05	2.6e-05	6.72	1.79e-11	0.18	FALSE
Brain	Grm5	mRNA stability	Grm5	0.1	1	0.09	4.9e-09	-6.7	2.03e-11	0.02	FALSE
Eye	Ctsc	gene expression	Ctsc	0.34	13	0.16	1.8e-03	-5.93	3.00e-09	0.18	FALSE
IC	Ctsc	alternative polyA	NM_017097.2	0.09	1	0.06	1.6e-03	-5.81	6.11e-09	0.04	FALSE
IC	Ctsc	alternative polyA	XM_008759637.4	0.08	1	0.05	2.6e-03	5.81	6.11e-09	0.04	TRUE
IC	Ctsc	gene expression	Ctsc	0.16	2571	0.13	4.2e-06	-5.23	1.66e-07	0.05	FALSE
IC	Grm5	gene expression	Grm5	0.3	44	0.24	1.4e-10	6.21	5.26e-10	0.2	FALSE
IC	Grm5	isoform ratio	XM_006229659.5	0.06	52	0.03	2.4e-02	6.38	1.73e-10	0.28	FALSE
IL	Ctsc	gene expression	Ctsc	0.44	18	0.11	1.6e-03	-7.33	2.26e-13	0.64	TRUE
LHb	Ctsc	gene expression	Ctsc	0.2	15	0.14	3.9e-04	-5.89	3.83e-09	0.14	TRUE
Liver	LOC102554680	gene expression	LOC102554680	0.05	13	0.04	7.2e-05	6.66	2.78e-11	0.64	FALSE
NAcc	Ctsc	alternative polyA	NM_017097.2	0.04	1	0.04	2.0e-06	-5.81	6.33e-09	0	FALSE
NAcc	Ctsc	alternative polyA	XM_008759637.4	0.04	27	0.04	1.0e-06	6.36	2.03e-10	0.27	FALSE
NAcc	Ctsc	gene expression	Ctsc	0.13	2571	0.19	2.3e-28	-6.16	7.41e-10	0.47	FALSE
NAcc	Grm5	gene expression	Grm5	0.08	1	0.08	7.3e-12	-6.95	3.75e-12	0.11	FALSE
NAcc	Tyr	gene expression	Tyr	0.02	2904	0.01	1.3e-02	6.45	1.09e-10	0.42	TRUE
NAcc	Ctsc	isoform ratio	NM_017097.2	0.05	1	0.05	2.9e-08	-5.81	6.33e-09	0	FALSE
NAcc	Ctsc	isoform ratio	XM_008759637.4	0.05	1	0.05	1.5e-07	5.81	6.33e-09	0	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151448822	0.02	1	0.01	1.7e-03	5.81	6.33e-09	0.02	FALSE
NAcc	Ctsc	intron excision ratio	chr1_151443766_151458158	0.02	4	0.01	8.6e-03	-6.24	4.51e-10	0.52	FALSE
NAcc	Grm5	mRNA stability	Grm5	0.03	1	0.03	3.3e-05	-6.95	3.75e-12	0.05	FALSE
OFC	Grm5	gene expression	Grm5	0.23	11	0.16	1.0e-04	-6.84	7.99e-12	0.44	TRUE
PL	Ctsc	alternative polyA	NM_017097.2	0.03	2571	0.02	1.7e-03	5.4	6.49e-08	0.23	FALSE
PL	Ctsc	gene expression	Ctsc	0.21	2571	0.21	1.0e-22	-5.76	8.32e-09	0.1	FALSE
PL	Grm5	gene expression	Grm5	0.03	2746	0.02	2.8e-03	6.07	1.30e-09	0.31	FALSE
PL	Ctsc	isoform ratio	NM_017097.2	0.02	2571	0.02	2.0e-03	5.4	6.57e-08	0.2	FALSE
PL	Ctsc	isoform ratio	XM_008759637.4	0.02	2571	0.02	2.0e-03	-5.4	6.69e-08	0.19	TRUE
PL	Grm5	intron excision ratio	chr1_150723078_150733678	0.03	2746	0.02	1.7e-03	5.56	2.63e-08	0.13	TRUE