LOC120096594

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC120096594	0.11	0.05	1.0e-13	0.09	0.12	0.13	0.13	4.3e-10	1.7e-13	1.2e-14	2.5e-14
2	Brain	gene expression	LOC120096594	0.08	0.05	2.8e-07	0.08	0.08	0.08	0.08	7.8e-08	7.2e-08	6.7e-08	7.8e-08
3	LHb	mRNA stability	LOC120096594	0.11	0.07	3.5e-03	0.12	0.06	0.01	0.08	9.2e-04	1.2e-02	2.1e-01	7.0e-03
4	pVTA	gene expression	LOC120096594	0.13	0.06	6.3e-15	0.18	0.19	0.16	0.18	1.1e-14	7.0e-15	7.6e-13	1.1e-14
5	LHb	gene expression	LOC120096594	0.32	0.14	2.2e-07	0.19	0.24	0.2	0.21	2.7e-05	2.6e-06	1.6e-05	9.1e-06
6	Brain	mRNA stability	LOC120096594	0.04	0.02	2.6e-04	0.03	0.03	0.03	0.02	1.8e-03	6.6e-04	1.7e-03	6.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.5	2.1	-1.4	0.9	0.0	0.3	0.3	-0.1
Area under the delay curve	0.6	0.7	1.1	-1.0	0.9	0.7	0.8	0.7	0.9
BMI with tail	0.2	0.6	1.7	0.2	-0.3	-1.0	-0.8	-0.6	-1.3
BMI without tail	0.1	0.3	1.3	0.0	-0.1	-1.1	-0.4	-0.5	-0.4
Body weight	0.1	0.3	0.8	-0.0	-0.1	-0.9	-0.6	-0.7	-0.5
Weight adjusted by age	0.3	0.4	0.6	0.5	-0.7	-0.7	-0.6	-0.8	-0.4
Bone surface	0.1	0.2	0.6	-0.7	0.4	-0.6	-0.3	-0.3	-0.3
Bone volume	0.2	0.3	0.8	-0.7	0.2	-0.5	-0.3	-0.2	-0.9
Breakpoint value in progressive ratio session	1.9	2.3	3.2	-1.3	1.7	1.1	1.7	1.8	1.3
Number of licking bursts	0.1	0.2	0.6	0.1	-0.3	-0.4	-0.6	-0.8	-0.0
Context. condit. distance diff. score	3.6	4.4	6.3	1.9	-2.1	-2.1	-2.0	-1.9	-2.5
Locomotion velocity, session 1	0.5	0.5	0.9	0.9	-0.7	-1.0	-0.6	-0.8	-0.2
Locomotion distance, session 1	0.5	0.6	1.1	1.1	-0.9	-1.0	-0.6	-0.6	-0.2
Locomotion velocity, session 2	0.3	0.3	0.6	-0.1	0.4	0.1	0.8	0.8	0.7
Locomotion distance, session 2	1.6	2.2	2.9	-1.1	1.4	1.2	1.7	1.7	1.7
Locomotion velocity, session 3	0.8	0.9	1.2	0.7	-1.1	-0.9	-1.0	-0.9	-1.1
Locomotion distance, session 3	1.7	1.8	2.5	1.4	-1.4	-1.6	-1.2	-1.0	-1.3
Stereotopy head waving bouts, day 3	1.2	1.5	3.0	-0.9	0.8	1.6	1.3	1.7	0.1
Stereotopy head waving duration, day 3	1.4	1.6	4.6	2.1	-1.6	-0.2	-0.5	-0.1	-1.5
Locomotion velocity, session 7	3.5	3.8	4.4	2.1	-2.1	-1.9	-1.8	-1.7	-2.1
Locomotion distance, session 7	4.3	5.5	10.8	3.3	-2.8	-1.7	-2.1	-2.0	-1.7
Stereotopy head waving bouts, day 7	0.8	0.9	1.5	-1.0	0.9	1.2	0.9	1.1	0.4
Stereotopy head waving duration, day 7	4.4	5.3	8.6	-2.9	2.5	2.2	2.2	2.2	1.6
Locomotion velocity, session 8	0.3	0.4	0.7	-0.8	0.8	0.3	0.6	0.5	0.5
Locomotion distance, session 8	1.3	1.9	2.6	1.5	-1.4	-1.6	-1.2	-1.1	-1.3
Degree of sensitization distance	1.5	1.6	3.1	1.8	-1.5	-0.6	-1.1	-1.0	-1.2
Degree of sensitization stereotypy	2.3	2.5	4.9	-2.2	1.9	1.4	1.3	1.3	1.1
Conditioned locomotion	0.3	0.4	0.8	-0.1	0.4	0.7	0.8	0.9	0.4
Cocaine response after cond. corrected	0.3	0.3	0.5	-0.3	0.6	0.2	0.7	0.7	0.7
Cocaine response after cond. not corrected	0.1	0.1	0.3	0.3	0.1	-0.3	0.2	0.0	0.6
Cocaine response before conditioning	0.3	0.4	0.7	0.6	-0.7	-0.6	-0.7	-0.8	-0.3
Saline control response	0.2	0.2	0.6	0.0	-0.4	-0.4	-0.6	-0.7	-0.1
Bone: connectivity density	2.5	4.0	6.8	-2.6	2.5	1.1	1.8	1.7	1.8
Bone: cortical apparent density	0.6	0.8	2.3	-1.5	1.1	0.6	0.7	0.7	0.2
Bone: cortical area	1.1	1.6	2.7	0.5	-1.2	-1.1	-1.6	-1.6	-1.3
Bone: cortical porosity	1.4	1.6	2.1	-1.5	1.2	1.2	1.2	1.2	1.1
Bone: cortical porosity	1.8	2.0	3.2	-1.8	1.4	1.4	1.3	1.3	1.0
Bone: cortical thickness	1.1	1.9	3.4	0.5	-1.3	-1.2	-1.7	-1.8	-1.2
Bone: cortical thickness	0.0	0.0	0.1	-0.2	0.0	0.3	0.1	0.1	0.1
Bone: cortical tissue density	0.6	0.8	2.2	-1.5	1.1	0.5	0.7	0.7	0.2
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	0.2	0.1	0.2	0.6	0.8	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.8	0.4	-0.3	-0.7	-0.0	0.2	-0.9
Condit. Reinf. active responses	0.8	1.0	2.1	-0.4	0.7	1.1	1.2	1.4	0.8
Condit. Reinf. inactive responses	0.8	1.0	1.9	-0.7	0.8	1.4	0.9	1.0	1.0
Incentive salience index mean	0.7	0.9	1.5	-0.7	1.0	0.6	1.2	1.2	0.9
Condit. Reinf. lever presses	1.7	2.4	3.4	-1.7	1.7	1.2	1.5	1.3	1.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.8	-0.6	-0.1	-0.5	-0.6	0.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.4	-0.1	-0.3	-0.0	-0.2	0.1
Condit. Reinf. active responses	0.7	0.9	1.4	1.2	-1.2	-0.7	-1.0	-1.1	-0.6
Condit. Reinf. inactive responses	1.5	1.9	2.6	1.4	-1.6	-1.1	-1.5	-1.5	-1.2
Condit. Reinf. lever presses	0.4	0.5	1.4	-0.7	0.7	0.7	0.5	0.3	1.2
Condit. Reinf. lever reinforcers received	0.3	0.4	0.7	0.8	-0.8	-0.4	-0.7	-0.8	-0.2
Conditioned reinforcement - actives	0.6	1.1	1.7	1.1	-1.3	-0.0	-1.2	-1.2	-0.7
Conditioned reinforcement - inactives	1.5	2.2	3.1	-0.7	1.3	1.3	1.7	1.8	1.7
Conditioned locomotion	0.3	0.4	1.0	0.4	-0.5	-0.7	-0.8	-1.0	-0.1
Patch foraging indifference point 0 sec	2.3	4.3	5.5	2.2	-2.3	-1.8	-2.2	-2.2	-1.6
Patch foraging indifference point AUC	1.9	2.7	3.7	1.9	-1.6	-1.9	-1.4	-1.3	-1.6
Delay disc. indifference point, 0s delay	0.6	0.6	1.3	-0.6	0.6	0.9	0.7	0.5	1.1
Delay disc. indifference point, 16s delay	1.0	1.1	2.1	-1.4	1.2	1.0	1.0	0.9	0.7
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.4	0.4	0.1	0.2	0.2	0.1
Delay disc. indifference point, 24s delay	0.8	0.8	1.9	-1.4	0.9	1.0	0.7	0.8	0.3
Delay disc. indifference point, 4s delay	0.5	0.5	1.2	-0.6	0.7	0.5	0.8	0.5	1.1
Delay disc. indifference point, 8s delay	0.2	0.2	0.3	-0.5	0.5	0.2	0.5	0.5	0.6
Indifference point function ln k	1.1	1.9	2.8	-1.2	1.3	1.7	1.4	1.4	1.4
Indifference point function log k	1.1	1.9	2.8	-1.2	1.3	1.7	1.4	1.4	1.4
Patch foraging total patch changes 0 sec	3.4	6.4	7.9	2.6	-2.8	-2.3	-2.7	-2.7	-2.1
Patch foraging total patch changes 12 sec	1.8	2.3	3.4	1.6	-1.5	-1.8	-1.5	-1.6	-1.0
Patch foraging total patch changes 18 sec	4.6	7.1	8.1	2.8	-2.8	-2.8	-2.6	-2.7	-2.2
Patch foraging total patch changes 24 sec	2.8	4.7	5.3	2.2	-2.3	-2.1	-2.3	-2.3	-1.8
Patch foraging total patch changes 6 sec	3.7	5.7	9.1	2.6	-2.4	-3.0	-2.2	-2.3	-1.7
Patch foraging time to switch 0 sec	0.8	1.7	3.1	-1.8	1.5	1.0	1.0	0.6	1.6
Patch foraging water rate 0 sec	0.3	0.6	1.7	1.3	-1.0	-0.4	-0.4	-0.3	-0.6
Patch foraging water rate 12 sec	0.1	0.3	1.3	1.1	-0.6	0.2	0.1	0.1	-0.0
Patch foraging water rate 18 sec	1.3	2.0	3.7	-1.1	1.5	1.3	1.7	1.9	0.7
Patch foraging water rate 24 sec	0.3	0.4	1.1	-0.4	0.5	0.6	0.9	1.0	0.2
Patch foraging water rate 6 sec	0.2	0.2	0.6	0.4	0.0	0.4	0.5	0.8	-0.3
Seeking ratio, delayed vs. immediate footshock	2.0	2.4	3.0	-1.4	1.7	1.2	1.7	1.6	1.7
Distance traveled before self-admin	0.3	0.4	1.1	0.3	-0.3	-1.0	-0.7	-0.8	-0.5
Distance traveled after self-admin	0.2	0.3	0.4	0.3	-0.6	-0.1	-0.6	-0.7	-0.6
Extensor digitorum longus weight	1.3	5.0	9.1	-3.0	2.7	1.3	1.9	1.4	2.6
Bone: elastic displacement	0.1	0.1	0.4	0.1	-0.2	0.6	0.0	0.1	-0.3
Bone: elastic work	0.1	0.1	0.1	0.0	-0.3	0.2	-0.3	-0.4	-0.4
Bone: endosteal estimation	0.3	0.6	1.1	0.2	-0.5	-0.9	-0.8	-0.9	-1.0
Bone: endosteal perimeter	0.1	0.3	0.5	0.7	-0.5	-0.3	-0.6	-0.7	-0.4
Epididymis fat weight	0.5	1.9	2.9	1.2	-1.2	-1.7	-1.4	-1.5	-1.1
Delta time in closed arm before/after self-admin	2.7	2.5	3.2	1.7	-1.8	-1.3	-1.6	-1.5	-1.6
Delta time in open arm before/after self-admin	0.4	0.4	1.2	-0.7	0.5	1.1	0.3	0.3	0.5
Diff in mean of infusions in LGA sessions	0.5	0.7	1.2	-0.5	0.9	0.4	1.1	1.1	0.7
Delay discount exponential model param	0.4	0.4	0.7	0.8	-0.7	-0.3	-0.6	-0.5	-0.7
Extinction: sum of active levers before priming	0.1	0.1	0.3	0.5	-0.3	0.2	0.0	0.1	0.2
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.4	0.2	0.2	0.0	0.1	-0.2
Bone: final force	0.1	0.2	1.1	-1.0	0.5	0.0	0.1	-0.1	0.1
Bone: final moment	0.3	0.4	1.5	-1.2	0.8	0.3	0.4	0.2	0.3
Food consumed during 24 hour testing period	0.0	0.0	0.1	0.2	-0.1	-0.2	0.1	0.2	-0.2
Glucose	0.1	0.1	0.3	0.2	-0.1	-0.5	-0.2	-0.1	-0.5
Heart weight	0.1	0.1	0.2	-0.1	0.3	-0.3	0.4	0.5	-0.2
Delay discount hyperbolic model param	0.4	0.4	0.7	0.8	-0.7	-0.4	-0.6	-0.5	-0.8
Intermittent access intake day 1-15 change	1.4	2.8	6.1	-1.7	1.4	2.5	1.4	1.5	1.3
Intermittent access intake escalation	1.5	3.1	6.3	-1.7	1.6	2.5	1.5	1.5	1.5
Intermittent access intake escalation 2	3.6	4.1	7.3	-1.9	1.8	2.7	1.8	1.8	2.0
Intermitt. access day 1 inactive lever presses	0.9	3.6	5.2	2.3	-2.2	-1.3	-1.7	-1.5	-2.1
Intermitt. access day 15 inactive lever presses	1.0	2.1	3.2	-1.5	1.5	1.2	1.6	1.8	0.8
Intermitt. access escalation Index	0.1	0.1	0.4	0.2	-0.0	-0.6	-0.1	-0.3	-0.2
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.6	-0.2	0.4	0.3	0.3	0.4
Intermittent access day 15 total infusions	1.5	2.3	4.8	-0.9	1.1	2.2	1.5	1.6	1.4
Intermittent access terminal intake (last 3 days)	2.3	3.0	6.1	-0.9	1.3	2.5	1.8	1.9	1.7
Intermittent access total infusions	0.4	0.5	1.0	-0.1	0.3	1.0	0.7	0.8	0.8
Intermittent access day 1 locomotion	0.9	1.2	1.9	1.4	-1.3	-1.0	-1.0	-0.9	-0.9
Intermittent access day 15 total locomotion	0.3	0.6	1.4	-0.4	0.6	1.2	0.7	0.7	0.9
Intermittent access total locomotion	0.1	0.1	0.4	0.6	-0.4	-0.5	-0.2	-0.2	-0.0
Intermittent access standard deviation	0.1	0.2	0.9	-0.5	0.0	1.0	-0.1	-0.0	0.3
Left kidney weight	0.2	1.0	1.8	-0.5	-0.2	-1.3	-1.1	-1.3	-1.0
Right kidney weight	0.7	3.0	4.8	1.2	-1.5	-2.2	-1.9	-2.1	-1.2
Cocaine induced anxiety	0.5	0.8	1.1	-0.9	0.8	1.1	0.9	0.9	0.7
Post-drug Anxiety	1.1	1.2	3.1	-1.8	1.4	0.7	0.8	0.7	0.7
Baseline Anxiety	0.2	0.2	1.1	-0.1	0.2	-1.0	-0.2	-0.2	-0.3
Tail length	0.2	0.9	2.0	0.8	-0.7	-1.4	-0.9	-1.1	-0.1
Length with tail	0.1	0.3	0.6	0.3	-0.3	-0.6	-0.5	-0.8	0.4
Length without tail	0.2	0.7	1.4	0.7	-0.9	-0.6	-1.0	-1.2	-0.5
Times rat made contact with spout	0.1	0.1	0.2	0.2	-0.3	-0.1	-0.3	-0.5	0.0
Lifetime Intake	0.2	0.2	0.6	-0.1	0.2	0.8	0.4	0.5	0.5
Liver weight, left	1.4	2.3	2.8	1.2	-1.5	-1.6	-1.6	-1.7	-1.5
Liver weight, right	0.0	0.1	0.2	-0.1	0.2	-0.2	0.4	0.5	-0.1
Locomotor activity	5.3	8.3	12.3	3.5	-3.2	-2.9	-2.7	-2.6	-2.1
Locomotor testing distance	5.3	9.6	13.1	3.6	-3.4	-3.0	-3.1	-3.2	-2.1
Locomotor testing rearing	2.2	4.4	5.3	2.3	-2.2	-2.2	-2.2	-2.2	-1.5
Locomotion in novel chamber	1.9	2.4	4.6	-0.9	1.2	2.2	1.4	1.3	1.9
Locomotion in novel chamber post-restriction	0.3	0.5	1.3	0.2	-0.4	-1.2	-0.7	-0.8	-0.7
Fecal boli incidents, locomotor time 1	3.5	5.0	5.9	2.3	-2.3	-2.4	-2.3	-2.3	-1.8
Change in fecal boli incidents, locomotor task	1.3	1.3	1.6	-1.0	1.3	1.1	1.2	1.2	1.0
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.3	-0.1	-0.1	-0.1	-0.3	0.5
Bouts of movement, locomotor time 1	0.1	0.1	0.6	-0.3	0.0	0.4	-0.2	-0.1	-0.7
Total resting periods, locomotor time 1	0.2	0.2	1.0	-0.4	-0.1	0.3	-0.4	-0.3	-1.0
Rest time, locomotor task time 1	1.2	1.5	2.4	1.5	-1.2	-1.0	-1.1	-0.9	-1.5
Distance moved, locomotor task time 1	1.3	2.0	3.7	-1.4	1.1	1.9	1.3	1.3	1.3
Vertical activity count, locomotor time 1	1.9	4.6	5.9	-1.9	2.1	2.3	2.2	2.0	2.4
Time >=10cm from walls, locomotor time 2	1.4	2.1	2.6	-1.2	1.4	1.2	1.6	1.6	1.6
Bouts of movement, locomotor time 2	0.2	0.3	0.9	0.6	-0.6	-0.5	-0.4	-0.2	-0.9
Total resting periods, locomotor time 2	0.5	0.9	1.7	1.1	-1.0	-0.8	-0.7	-0.5	-1.3
Rest time, locomotor task time 2	4.6	5.8	9.4	3.1	-2.6	-2.2	-2.1	-2.0	-2.4
Distance moved, locomotor task time 2	7.3	8.7	11.6	-3.2	2.8	3.4	2.7	2.5	2.9
Vertical activity count, locomotor time 2	7.9	10.9	13.4	-3.2	3.3	3.3	3.3	3.1	3.7
Light reinforcement 1	0.3	0.7	2.8	0.4	-0.4	-1.7	-0.6	-0.7	-0.6
Light reinforcement 2	0.7	1.1	1.7	1.1	-1.1	-1.3	-1.0	-1.0	-0.8
Bone: marrow area	0.2	0.5	0.9	0.2	-0.4	-0.8	-0.8	-0.8	-1.0
Bone: maximum diameter	0.6	1.1	1.6	0.8	-1.1	-0.7	-1.3	-1.3	-1.1
Bone: maximum force	0.3	0.5	1.2	-0.2	-0.4	-0.6	-0.9	-1.1	-0.6
Bone: maximum moment	0.1	0.2	0.6	-0.4	-0.2	-0.4	-0.6	-0.8	-0.4
Mean time between licks in bursts	1.0	2.6	4.0	2.0	-1.8	-1.4	-1.3	-1.0	-1.9
Mean num. licks in bursts	0.1	0.1	0.2	0.3	0.0	0.3	0.3	0.5	0.0
Cd content in liver	1.1	1.2	1.7	1.3	-1.1	-1.0	-1.0	-0.9	-1.1
Co content in liver	1.2	1.4	3.2	-1.0	1.2	0.4	1.2	1.0	1.8
Cu content in liver	0.1	0.1	0.2	0.4	-0.1	0.5	0.0	0.0	0.1
Fe content in liver	0.2	0.2	0.3	-0.5	0.4	0.5	0.4	0.5	0.1
K content in liver	3.6	3.4	4.5	1.2	-1.7	-2.0	-2.0	-2.0	-2.1
Mg content in liver	3.4	3.5	4.3	1.9	-2.0	-1.7	-1.8	-1.6	-2.1
Mn content in liver	7.5	8.4	9.7	-3.1	3.1	2.5	3.0	2.9	2.7
Na content in liver	0.0	0.0	0.1	-0.2	0.2	-0.4	-0.0	0.0	-0.1
Rb content in liver	0.1	0.1	0.3	-0.4	0.4	-0.5	0.1	0.1	-0.2
Se content in liver	1.0	1.2	2.5	-1.1	0.9	1.6	1.0	1.2	0.5
Sr content in liver	0.2	0.2	0.6	-0.8	0.4	-0.4	-0.0	-0.1	-0.0
Zn content in liver	1.7	1.9	4.1	2.0	-1.5	-1.2	-1.0	-0.7	-1.5
Bone: minimum diameter	1.2	2.2	2.8	1.0	-1.5	-1.4	-1.6	-1.7	-1.7
Time in familiar zone, hab. session 1	0.3	0.2	0.9	0.1	0.4	-0.5	0.4	0.3	0.9
Time in novel zone, hab. session 1	0.2	0.2	0.8	0.1	-0.4	0.4	-0.4	-0.2	-0.9
Total zone transitions, hab. session 1	0.5	0.7	1.5	-0.1	0.6	0.9	1.0	0.9	1.2
Total locomotion distance, hab. session 1	9.6	13.5	32.1	5.7	-4.4	-2.4	-2.7	-2.2	-3.4
Locomotion velocity, hab. session 1	9.4	13.3	30.5	5.5	-4.4	-2.3	-2.8	-2.4	-3.3
Time in familiar zone, hab. session 2	0.2	0.2	0.8	0.3	0.1	-0.9	0.1	0.2	-0.2
Time in novel zone, hab. session 2	0.5	0.5	2.2	-0.6	0.3	1.5	0.3	0.3	0.5
Total zone transitions, hab. session 2	0.0	0.1	0.3	-0.2	0.1	-0.1	0.1	-0.1	0.5
Total locomotion distance, hab. session 2	9.1	11.9	22.4	4.7	-4.1	-2.7	-2.9	-2.6	-3.1
Locomotion velocity, hab. session 2	8.6	11.5	21.7	4.7	-4.0	-2.7	-2.8	-2.6	-3.0
Novel to familiar place preference ratio	0.2	0.2	0.5	-0.2	0.2	0.7	0.5	0.7	0.1
Novelty place preference	0.5	0.5	0.9	-0.5	0.6	1.0	0.8	0.9	0.5
Time in novel zone, NPP test	1.0	1.1	1.7	-0.9	0.9	1.3	1.1	1.2	0.8
Total zone transitions, NPP test	0.7	1.0	1.3	1.1	-1.1	-1.2	-1.0	-1.1	-0.6
Total locomotion distance, NPP test	12.4	16.9	30.2	5.5	-4.9	-3.0	-3.6	-3.3	-3.8
Locomotion velocity, NPP test	13.4	18.9	33.2	5.8	-5.1	-3.2	-3.9	-3.6	-3.9
Intraocular pressure	1.1	1.5	3.0	-0.5	0.9	1.7	1.4	1.7	0.6
Delta distance traveled before/after self-admin	0.4	0.5	0.9	0.5	-0.9	0.0	-0.8	-0.7	-0.8
Delta ambulatory time before/after self-admin	0.2	0.2	0.5	0.5	-0.7	0.2	-0.4	-0.3	-0.4
Parametrial fat weight	0.9	2.0	2.7	1.7	-1.6	-1.2	-1.3	-1.3	-1.5
Pavlov. Cond. lever latency	0.6	0.7	1.2	1.1	-0.9	-0.6	-0.9	-0.8	-0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.2	0.1	0.6	0.4	0.5	0.2
Pavlov. Cond. change in total contacts	1.2	1.3	2.0	-1.1	1.0	1.4	1.1	1.2	0.9
Pavlov. Cond. index score	0.4	0.5	0.7	-0.6	0.6	0.7	0.8	0.8	0.5
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	0.3	0.3	0.4	0.4	0.2
Pavlov. Cond. lever contacts	0.6	0.8	1.0	-1.0	0.9	0.7	1.0	0.9	0.7
Pavlov. Cond. magazine entry number	0.7	0.9	1.7	0.4	-0.6	-1.3	-1.1	-1.2	-0.8
Pavlov. Cond. intertrial magazine entries	2.4	2.8	3.8	-1.2	1.6	1.9	1.9	2.0	1.5
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.1	-0.9	0.9	1.0	1.0	1.0	0.7
Pavlov. Cond. response bias	0.8	1.0	1.5	-0.8	0.8	1.2	1.1	1.1	0.9
Pavlov. Cond. lever latency	0.5	0.6	1.5	0.6	-0.7	-0.7	-0.7	-0.6	-1.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.0	-1.0	0.8	1.0	0.5	0.6	0.8
Pavlov. Cond. change in total contacts	0.0	0.0	0.2	-0.1	0.1	0.1	0.0	0.0	0.5
Pavlov. Cond. index score	0.4	0.6	1.2	-0.7	0.7	0.8	0.6	0.5	1.1
Pavlov. Cond. latency score	0.4	0.6	1.3	-0.7	0.7	0.7	0.6	0.5	1.1
Pavlov. Cond. lever contacts	0.4	0.6	1.2	-0.8	0.7	0.6	0.7	0.6	1.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.3	1.1	-0.9	-0.8	-0.6	-0.7	-0.8
Pavlov. Cond. intertrial magazine entries	2.3	3.4	4.7	2.1	-1.9	-2.2	-1.6	-1.5	-1.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	-0.7	0.6	0.6	0.4	0.4	0.9
Pavlov. Cond. response bias	0.7	0.9	1.4	-0.9	0.9	1.1	0.9	0.9	1.2
Time in closed arm before self-admin	0.3	0.4	1.2	-1.1	0.7	0.5	0.1	0.0	0.7
Time in closed arm after self-admin	0.5	0.5	0.7	0.7	-0.8	-0.7	-0.9	-0.8	-0.4
Time in open arm before self-admin	4.5	5.0	8.0	2.8	-2.4	-2.3	-1.8	-1.7	-2.1
Time in open arm after self-admin	0.8	0.9	1.3	1.1	-1.1	-0.3	-0.9	-0.8	-1.1
Bone: periosteal estimation	0.8	1.6	2.5	0.5	-1.1	-1.2	-1.5	-1.6	-1.5
Bone: periosteal perimeter	0.6	1.0	1.4	1.0	-1.1	-0.9	-1.1	-1.2	-0.8
Bone: post-yield work	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1	-0.1
Progressive ratio test 1 active lever presses	0.3	0.3	0.8	0.9	-0.8	-0.2	-0.3	-0.2	-0.6
Progressive ratio test 1 breakpoint	0.4	0.5	1.1	1.0	-0.9	-0.3	-0.5	-0.3	-0.8
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.4	0.0	0.0	0.0	0.3	0.6	-0.7
Progressive ratio test 2 active lever presses	0.6	0.7	1.3	-0.1	0.4	1.1	0.9	1.0	1.1
Progressive ratio test 2 breakpoint	0.6	0.7	1.2	-0.0	0.4	1.1	0.9	0.9	1.0
Progressive ratio test 2 inactive lever presses	0.8	1.3	2.9	-0.3	0.7	1.7	1.2	1.4	0.9
Incentive Sensitization - Responses	2.2	3.1	3.6	-1.5	1.7	1.7	1.9	1.9	1.9
Incentive Sensitization - Breakpoint	2.3	3.0	3.6	-1.4	1.7	1.7	1.8	1.8	1.9
Sum of active levers in priming session hrs 5-6	1.5	1.4	2.0	-1.4	1.3	1.2	0.9	0.8	1.2
Progressive ratio	3.4	5.4	6.8	2.1	-2.2	-2.5	-2.6	-2.6	-1.8
Food seeking constrained by brief footshock	4.0	5.0	7.9	2.2	-2.1	-2.8	-2.2	-2.4	-1.4
Seeking ratio, punishment vs. effort	0.1	0.1	0.3	-0.2	0.4	0.2	0.6	0.5	0.1
Retroperitoneal fat weight	2.0	8.4	9.2	3.0	-2.9	-2.9	-3.0	-3.0	-2.5
Reaction time number correct	0.1	0.1	0.5	-0.7	0.1	-0.0	-0.1	-0.1	-0.6
Reaction time mean minus median	0.8	2.1	3.7	-1.9	1.5	1.4	1.3	1.2	1.2
Reaction time mean minus median AUC	1.5	3.9	5.8	-2.4	2.0	2.0	1.8	1.7	1.7
Reaction time num false alarms	0.3	0.4	0.9	-1.0	0.8	0.2	0.5	0.4	0.7
Reaction time num false alarms AUC	0.2	0.4	0.9	-0.9	0.8	0.0	0.4	0.3	0.7
Reaction time trials correct on left	0.1	0.1	0.5	-0.7	0.1	-0.0	-0.1	-0.1	-0.6
Reaction time trials on left	0.1	0.2	0.6	-0.8	0.2	0.0	-0.1	-0.0	-0.5
Reaction time mean	1.7	2.7	4.9	-2.2	1.7	1.5	1.4	1.3	1.5
Reaction time mean AUC	1.6	2.6	4.6	-2.1	1.7	1.5	1.4	1.2	1.6
Median of all reaction times	1.6	2.3	4.4	-2.1	1.6	1.4	1.3	1.2	1.4
Reaction time omissions	3.3	4.8	8.7	-3.0	2.5	1.9	1.8	1.6	2.1
Reaction time false alarm rate	0.2	0.3	1.1	-0.4	0.6	0.1	0.5	0.4	1.0
Reaction time premature initiation rate	5.4	7.5	10.4	-3.2	3.0	2.3	2.8	2.7	2.3
Reaction time premature initiations	3.2	5.8	10.8	-3.3	2.7	1.9	2.3	2.3	1.6
Std. dev. reaction times	0.9	1.6	3.3	-1.8	1.4	1.0	1.1	0.9	1.3
Reaction time trials completed	0.1	0.2	0.6	-0.8	0.2	0.0	-0.1	-0.0	-0.5
Reaction time trials AUC	0.1	0.1	0.6	-0.8	0.3	0.1	0.0	0.1	-0.4
Run reversals in cocaine runway, females	0.2	0.2	0.6	-0.8	0.7	-0.3	0.3	0.3	0.1
Run reversals in cocaine runway, males	0.5	0.6	1.4	0.5	-0.6	-0.6	-0.7	-0.7	-1.2
Latency to leave start box in cocaine runway	4.0	4.5	5.9	1.7	-2.3	-1.5	-2.4	-2.3	-2.4
Latency to leave start box in cocaine runway, F	1.9	2.2	4.2	0.8	-1.5	-0.9	-1.7	-1.5	-2.0
Latency to leave start box in cocaine runway, M	2.7	2.5	3.3	1.6	-1.8	-1.2	-1.8	-1.8	-1.2
Std. dev. time between licks in bursts	0.1	0.1	0.5	0.7	-0.3	-0.0	0.2	0.3	-0.0
Total sessions with >9 infusions	0.1	0.1	0.2	0.3	-0.4	-0.2	-0.4	-0.3	-0.4
Short access day 1 total inactive lever presses	0.9	1.2	1.4	1.2	-1.1	-1.1	-1.1	-1.0	-1.0
Short access day 10 total inactive lever presses	0.8	1.9	2.2	1.3	-1.4	-1.4	-1.4	-1.4	-1.5
Short access day 1 total infusions	0.2	0.2	0.4	-0.6	0.5	0.6	0.4	0.6	0.1
Short access day 10 total infusions	0.2	0.3	0.5	-0.3	0.3	0.7	0.5	0.7	0.3
Short access total infusions	0.1	0.2	0.5	-0.2	0.2	0.7	0.4	0.5	0.2
Short access day 1 locomotion	1.4	1.8	3.2	1.5	-1.2	-1.8	-1.2	-1.3	-0.9
Short access day 10 total locomotion	1.2	2.2	2.9	1.7	-1.7	-1.0	-1.6	-1.3	-1.5
Short access total locomotion	1.5	1.8	2.5	1.6	-1.5	-1.3	-1.3	-1.2	-1.1
One hour access (0.3 mA shock)	0.6	0.7	1.3	0.4	0.0	1.2	0.8	0.8	1.1
Compulsive drug intake	1.4	1.7	2.6	1.6	-1.5	-1.1	-1.1	-1.0	-1.4
One hour access (shock baseline)	1.3	2.1	3.4	-1.0	1.3	1.5	1.5	1.4	1.8
Social response proportion	0.3	0.3	0.9	0.0	-0.0	-0.9	-0.3	-0.6	0.6
Social responses	2.2	2.8	5.9	1.3	-1.4	-2.4	-1.7	-1.8	-1.0
Social time	0.4	0.5	0.9	-0.9	0.8	-1.0	0.4	0.2	0.6
Soleus weight	0.2	0.6	0.9	-1.0	0.9	0.1	0.8	0.7	0.9
Bone: stiffness	0.3	0.5	1.2	-0.1	-0.6	-0.6	-0.9	-1.1	-0.7
Tibialis anterior weight	1.1	3.7	7.6	-2.8	2.4	1.3	1.8	1.6	1.4
Time to tail flick, vehicle, before self-admin	1.0	1.0	1.4	-0.7	1.1	0.8	1.2	1.2	1.1
Time to tail flick, vehicle, after self-admin	3.7	4.9	5.4	2.3	-2.3	-2.2	-2.2	-2.2	-2.0
Time to tail flick, test, before self-admin	0.3	0.3	1.4	0.0	0.1	1.2	0.4	0.6	-0.0
Time to tail flick, test, after self-admin	2.5	2.6	3.2	1.7	-1.7	-1.8	-1.7	-1.8	-0.9
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.3	0.2	-0.6	-0.9	-1.1	-1.1	-0.8
Delta time to tail flick, test, before/after SA	0.7	0.7	1.3	0.6	-0.7	-1.1	-0.9	-1.0	-0.2
Tibia length	0.0	0.1	0.2	0.0	-0.1	-0.4	-0.2	-0.3	0.5
Ambulatory time before self-admin	0.2	0.2	0.4	-0.4	0.1	-0.7	-0.5	-0.6	-0.5
Ambulatory time after self-admin	0.0	0.0	0.1	-0.3	-0.1	0.2	-0.2	-0.2	-0.3
Bone: tissue strength	2.3	2.3	3.3	1.3	-1.4	-1.8	-1.6	-1.7	-1.1
Total heroin consumption	0.2	0.2	0.4	-0.2	0.4	0.3	0.5	0.7	0.3
Bone: trabecular number	0.1	0.2	0.4	-0.6	0.3	-0.5	-0.0	0.0	-0.3
Bone: trabecular spacing	0.1	0.1	0.3	0.1	-0.2	0.6	-0.0	-0.0	0.2
Bone: trabecular thickness	0.7	0.9	1.6	-1.0	1.0	0.9	1.0	1.3	0.0
Bone: trabecular tissue density	1.1	1.7	3.9	0.9	-1.1	-1.2	-1.2	-1.1	-2.0
Water consumed over 24 hours	0.7	1.0	1.3	-1.1	1.1	0.9	1.0	1.0	0.8
Number of responses in last shaping day	0.3	0.4	0.5	0.6	-0.7	-0.0	-0.7	-0.6	-0.7