Pdcl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IC	gene expression	Pdcl2	0.11	0.08	5.7e-03	0.01	0.04	0.04	0.05	7.2e-02	9.6e-03	8.2e-03	4.0e-03
2	pVTA	intron excision ratio	chr14_32241901_32243057	0.06	0.04	5.2e-03	0.01	0.02	0.02	0.02	2.1e-02	1.2e-02	9.3e-03	7.7e-03
3	Adipose	gene expression	Pdcl2	0.04	0.02	3.5e-05	0.04	0.04	0.02	0.03	3.4e-05	2.5e-05	8.7e-04	1.3e-04
4	Brain	mRNA stability	Pdcl2	0.08	0.07	5.4e-03	0.05	0.02	0.02	0.04	1.8e-05	2.3e-03	6.0e-03	1.1e-04
5	pVTA	intron excision ratio	chr14_32243265_32249286	0.09	0.06	5.6e-04	0.04	0.04	0.06	0.05	4.7e-04	1.5e-04	3.3e-05	3.4e-05
6	PL	intron excision ratio	chr14_32243265_32249286	0.04	0.03	6.5e-03	-0	0.01	0	0	6.6e-01	7.3e-02	1.5e-01	2.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.5	4.7	8.7	-2.2	-3.0	-0.6	2.1	2.8	-1.2
Area under the delay curve	0.4	0.6	1.1	-0.9	-1.0	-1.1	0.3	0.6	0.1
BMI with tail	0.3	1.0	1.8	-0.7	-0.9	0.8	1.3	1.2	-1.0
BMI without tail	0.2	0.9	1.5	-0.8	-1.0	0.2	1.0	1.2	-0.9
Body weight	0.5	2.3	4.9	-0.9	-2.1	0.2	1.4	2.2	-1.3
Weight adjusted by age	0.1	0.3	0.9	0.6	-0.2	0.5	-0.2	0.5	-1.0
Bone surface	1.2	2.3	4.2	-1.5	-1.8	-0.1	2.0	1.7	-1.0
Bone volume	1.3	2.7	4.8	-1.4	-2.0	0.2	1.8	2.2	-1.3
Breakpoint value in progressive ratio session	0.6	1.0	2.5	-1.0	0.2	-1.5	-0.5	-0.6	1.6
Number of licking bursts	0.3	1.0	1.5	-0.5	-1.2	0.1	1.1	1.2	-1.1
Context. condit. distance diff. score	1.4	1.7	5.2	1.3	0.4	2.3	0.1	0.5	-1.8
Locomotion velocity, session 1	0.2	0.3	0.7	0.8	0.3	0.5	-0.5	-0.2	-0.5
Locomotion distance, session 1	0.6	0.8	1.4	1.2	1.0	0.7	-1.0	-0.9	0.0
Locomotion velocity, session 2	0.5	0.6	1.2	0.3	0.7	-0.6	-1.1	-0.9	0.8
Locomotion distance, session 2	1.0	1.4	3.4	-0.5	0.6	-1.5	-0.9	-1.1	1.9
Locomotion velocity, session 3	0.3	0.3	1.2	0.4	0.3	1.1	0.3	0.1	-0.7
Locomotion distance, session 3	0.8	0.9	2.2	1.1	1.2	1.5	-0.3	-0.6	-0.4
Stereotopy head waving bouts, day 3	0.4	0.5	1.3	-0.1	0.5	-0.8	-0.7	-0.4	1.1
Stereotopy head waving duration, day 3	5.7	7.0	11.0	3.3	3.3	1.4	-3.2	-2.7	0.7
Locomotion velocity, session 7	1.7	1.8	4.8	1.6	-0.1	1.7	-0.3	0.8	-2.2
Locomotion distance, session 7	5.3	6.8	14.1	3.8	2.9	2.3	-2.7	-2.2	-0.8
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	-0.5	-0.0	-0.7	0.1	-0.0	0.7
Stereotopy head waving duration, day 7	3.0	3.7	7.9	-2.8	-1.9	-2.2	1.7	1.3	1.0
Locomotion velocity, session 8	0.2	0.3	0.8	-0.9	-0.4	-0.6	0.4	0.3	0.3
Locomotion distance, session 8	0.8	1.2	2.2	1.3	1.2	1.5	-0.7	-0.8	-0.5
Degree of sensitization distance	1.7	1.9	4.5	2.1	1.3	1.2	-1.5	-0.9	-0.7
Degree of sensitization stereotypy	2.5	2.8	5.9	-2.4	-1.8	-1.5	1.8	1.4	0.4
Conditioned locomotion	0.3	0.4	1.5	0.5	0.1	-0.7	-1.2	-0.2	0.4
Cocaine response after cond. corrected	0.2	0.4	0.6	-0.0	0.4	-0.7	-0.8	-0.7	0.7
Cocaine response after cond. not corrected	0.3	0.5	1.1	0.5	0.7	-0.3	-1.1	-1.0	0.3
Cocaine response before conditioning	0.1	0.2	0.4	0.5	0.2	0.5	-0.2	-0.1	-0.6
Saline control response	0.8	1.1	2.3	-0.4	-1.4	0.1	0.9	1.5	-1.2
Bone: connectivity density	2.6	4.1	9.1	-3.0	-2.2	-2.2	1.7	1.6	0.7
Bone: cortical apparent density	1.6	2.6	4.1	-2.0	-1.9	-0.8	1.8	1.8	-0.5
Bone: cortical area	2.0	3.3	6.3	-0.1	-2.0	1.0	1.7	2.3	-2.5
Bone: cortical porosity	0.8	0.9	2.1	-1.2	-1.1	-1.5	-0.1	0.7	0.3
Bone: cortical porosity	1.6	1.7	3.3	-1.6	-1.8	-1.6	0.3	1.4	0.0
Bone: cortical thickness	2.3	3.8	7.5	-0.3	-2.2	1.0	1.7	2.5	-2.7
Bone: cortical thickness	0.3	0.4	1.0	0.1	-1.0	-0.4	-0.4	0.9	-0.6
Bone: cortical tissue density	1.5	2.3	3.9	-2.0	-1.8	-0.8	1.8	1.7	-0.4
Condit. Reinf. active minus inactive responses	0.9	1.1	1.6	0.7	1.3	-0.1	-1.1	-1.2	1.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	0.5	0.5	-0.1	-0.1	0.1
Condit. Reinf. active responses	1.6	2.1	3.9	0.6	1.5	-0.7	-1.7	-1.6	2.0
Condit. Reinf. inactive responses	0.6	0.8	1.8	0.1	0.6	-0.8	-1.0	-0.9	1.3
Incentive salience index mean	0.6	0.8	2.2	-0.2	0.6	-0.8	-0.7	-0.8	1.5
Condit. Reinf. lever presses	0.7	1.1	2.5	-1.3	-0.4	-1.6	-0.0	-0.2	1.4
Condit. Reinf. active minus inactive responses	0.4	0.6	1.0	1.0	-0.8	0.1	-0.8	0.7	-0.9
Condit. Reinf. active-inactive response ratio	0.2	0.4	0.7	0.4	-0.9	-0.2	-0.3	0.8	-0.7
Condit. Reinf. active responses	0.5	0.7	1.6	1.3	-0.4	0.8	-0.6	0.5	-1.1
Condit. Reinf. inactive responses	0.6	0.9	2.4	1.2	0.7	1.5	-0.2	-0.4	-0.9
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.6	-0.5	-0.8	0.3	0.2	0.3
Condit. Reinf. lever reinforcers received	0.3	0.4	1.0	1.0	-0.3	0.5	-0.6	0.2	-0.7
Conditioned reinforcement - actives	0.2	0.6	1.6	1.3	0.5	1.0	-0.3	-0.1	-0.8
Conditioned reinforcement - inactives	1.0	2.7	5.1	0.4	1.4	-1.4	-1.8	-1.9	2.3
Conditioned locomotion	0.3	0.4	1.1	0.2	-0.6	0.4	0.6	0.6	-1.0
Patch foraging indifference point 0 sec	0.8	2.3	4.9	1.9	1.5	2.2	-1.0	-1.0	-1.1
Patch foraging indifference point AUC	0.8	1.8	4.0	1.3	1.8	2.0	-0.3	-1.4	0.0
Delay disc. indifference point, 0s delay	0.2	0.2	0.9	-0.1	-0.2	-0.9	-0.4	-0.1	0.3
Delay disc. indifference point, 16s delay	1.3	1.8	3.4	-1.6	-1.9	-1.2	1.1	1.6	-0.1
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	-0.5	-0.9	-0.4	0.0	0.8	-0.4
Delay disc. indifference point, 24s delay	0.9	1.5	2.7	-1.6	-1.4	-0.7	1.6	1.1	0.2
Delay disc. indifference point, 4s delay	0.5	0.5	1.4	-0.2	-1.0	-1.2	-0.5	0.7	-0.3
Delay disc. indifference point, 8s delay	0.1	0.1	0.4	-0.2	-0.4	-0.6	-0.3	0.1	0.1
Indifference point function ln k	0.2	0.7	2.6	-0.4	-0.7	-1.6	-0.7	0.4	0.5
Indifference point function log k	0.2	0.7	2.6	-0.4	-0.7	-1.6	-0.7	0.4	0.5
Patch foraging total patch changes 0 sec	1.0	3.1	7.3	2.1	1.6	2.7	-0.9	-1.0	-1.5
Patch foraging total patch changes 12 sec	0.6	0.8	2.3	1.0	0.8	1.5	-0.3	-0.5	-0.6
Patch foraging total patch changes 18 sec	1.2	2.8	7.4	2.1	1.2	2.7	-0.8	-0.6	-1.6
Patch foraging total patch changes 24 sec	0.7	2.3	5.9	1.6	1.6	2.4	-0.3	-1.0	-1.1
Patch foraging total patch changes 6 sec	1.7	2.9	5.9	2.0	1.8	2.4	-1.1	-1.4	-0.8
Patch foraging time to switch 0 sec	0.6	2.4	3.9	-2.0	-2.0	-1.6	1.2	1.6	-0.0
Patch foraging water rate 0 sec	0.6	2.1	3.8	1.9	1.7	0.7	-1.9	-1.4	0.2
Patch foraging water rate 12 sec	0.4	1.7	4.2	2.0	0.9	0.0	-2.1	-1.0	0.1
Patch foraging water rate 18 sec	0.4	0.9	2.4	-0.4	0.6	-1.2	-0.7	-0.9	1.5
Patch foraging water rate 24 sec	0.1	0.2	0.5	0.2	0.2	-0.6	-0.7	-0.1	0.5
Patch foraging water rate 6 sec	1.0	1.4	3.0	1.2	1.3	-0.0	-1.7	-1.2	0.8
Seeking ratio, delayed vs. immediate footshock	1.3	1.9	5.2	-1.1	1.1	-1.4	-0.2	-1.4	2.3
Distance traveled before self-admin	0.3	0.7	1.3	-0.3	-0.9	0.4	0.7	1.0	-1.1
Distance traveled after self-admin	0.2	0.3	0.8	0.1	-0.5	0.4	0.1	0.7	-0.9
Extensor digitorum longus weight	2.0	7.9	13.4	-3.6	-3.7	-2.8	2.3	2.8	0.1
Bone: elastic displacement	0.1	0.1	0.2	0.4	-0.4	0.1	-0.4	0.4	-0.4
Bone: elastic work	0.2	0.3	0.8	0.1	-0.7	0.2	0.1	0.6	-0.9
Bone: endosteal estimation	0.6	1.4	2.2	-0.4	-1.2	0.8	1.5	1.5	-1.3
Bone: endosteal perimeter	0.1	0.3	0.9	0.9	-0.2	0.5	0.1	0.3	-0.5
Epididymis fat weight	0.1	0.6	1.9	0.5	0.2	1.4	0.8	0.1	-0.7
Delta time in closed arm before/after self-admin	1.6	1.5	3.1	1.6	1.2	1.8	-0.8	-0.6	-0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.3	-0.5	-0.5	-0.5	0.4	0.2	0.2
Diff in mean of infusions in LGA sessions	0.2	0.4	0.8	-0.1	0.1	-0.9	-0.9	-0.4	0.8
Delay discount exponential model param	0.4	0.6	1.3	0.9	1.1	0.8	-0.4	-0.8	0.2
Extinction: sum of active levers before priming	1.3	1.9	3.7	0.9	1.9	0.4	-1.3	-1.9	1.2
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.3	-0.1	0.1	0.3	0.1	0.1
Bone: final force	2.5	4.0	8.8	-1.3	-3.0	-0.7	1.5	2.9	-1.6
Bone: final moment	2.5	4.0	9.3	-1.4	-3.0	-1.0	1.3	2.9	-1.4
Food consumed during 24 hour testing period	0.2	0.4	0.7	0.3	0.9	0.3	-0.4	-0.7	0.7
Glucose	0.1	0.1	0.2	-0.2	-0.2	0.3	0.3	0.4	-0.3
Heart weight	0.0	0.1	0.2	-0.1	-0.4	-0.2	-0.0	0.4	0.0
Delay discount hyperbolic model param	0.5	0.6	1.4	0.8	1.2	0.9	-0.3	-0.8	0.2
Intermittent access intake day 1-15 change	0.2	0.9	2.6	-0.9	-1.1	-1.6	0.3	0.6	0.9
Intermittent access intake escalation	0.2	1.1	3.0	-1.0	-1.1	-1.7	0.3	0.6	0.9
Intermittent access intake escalation 2	0.8	1.4	5.0	-0.9	-1.2	-2.2	-0.3	0.5	1.0
Intermitt. access day 1 inactive lever presses	0.2	2.4	5.4	2.3	1.4	2.2	-1.1	-0.7	-0.9
Intermitt. access day 15 inactive lever presses	0.2	0.9	2.6	-1.2	0.0	-1.2	0.3	-0.3	1.6
Intermitt. access escalation Index	0.0	0.1	0.2	0.1	-0.4	0.1	-0.4	0.4	-0.5
Intermittent access day 1 total infusions	0.6	1.9	3.1	1.4	1.7	-0.0	-1.7	-1.7	0.9
Intermittent access day 15 total infusions	0.5	1.3	2.3	0.5	0.5	-1.4	-1.5	-0.9	1.5
Intermittent access terminal intake (last 3 days)	1.2	2.1	3.7	0.7	0.9	-1.7	-1.9	-1.3	1.8
Intermittent access total infusions	0.7	0.8	1.4	0.8	0.8	-0.6	-1.2	-0.9	0.9
Intermittent access day 1 locomotion	0.7	1.3	2.6	1.6	1.4	1.2	-0.9	-1.0	-0.3
Intermittent access day 15 total locomotion	0.2	0.7	1.4	0.3	0.8	-0.6	-0.6	-1.1	1.2
Intermittent access total locomotion	0.3	0.4	0.9	1.0	0.8	0.3	-0.6	-0.7	0.1
Intermittent access standard deviation	0.0	0.1	0.2	-0.1	-0.3	-0.2	0.4	0.3	0.1
Left kidney weight	1.0	7.9	13.7	-2.0	-3.7	0.4	3.1	3.7	-2.5
Right kidney weight	0.2	1.3	2.5	0.4	-0.7	1.6	1.1	1.0	-1.6
Cocaine induced anxiety	0.2	0.5	1.0	-0.9	-0.8	-1.0	0.3	0.5	0.2
Post-drug Anxiety	3.4	3.8	7.1	-2.7	-2.2	-1.1	2.5	1.9	-0.1
Baseline Anxiety	0.1	0.2	0.7	-0.6	0.1	0.4	0.8	-0.1	0.2
Tail length	0.1	0.4	1.2	0.0	-0.7	0.4	0.4	0.7	-1.1
Length with tail	0.2	0.8	2.0	-0.1	-1.4	-0.1	0.4	1.3	-0.9
Length without tail	0.2	1.2	2.3	0.4	-1.5	0.6	0.4	1.5	-1.4
Times rat made contact with spout	0.1	0.1	0.3	0.1	-0.4	0.1	-0.1	0.4	-0.5
Lifetime Intake	0.3	0.4	0.6	0.6	0.7	-0.3	-0.7	-0.7	0.8
Liver weight, left	0.9	1.6	3.9	0.6	-1.0	1.3	0.5	1.5	-2.0
Liver weight, right	0.1	0.2	0.6	0.2	-0.5	-0.4	-0.7	0.5	-0.2
Locomotor activity	3.3	5.2	10.6	3.3	2.4	2.9	-1.7	-1.5	-1.1
Locomotor testing distance	2.1	5.2	10.4	3.2	2.3	3.1	-1.5	-1.4	-1.4
Locomotor testing rearing	0.5	1.8	4.5	1.8	1.3	2.1	-0.5	-0.6	-1.0
Locomotion in novel chamber	1.4	1.9	3.2	0.4	0.8	-1.5	-1.8	-1.5	1.6
Locomotion in novel chamber post-restriction	0.3	0.8	1.3	-0.3	-1.0	0.5	1.1	1.0	-1.0
Fecal boli incidents, locomotor time 1	0.8	2.2	5.3	1.8	1.3	2.3	-0.5	-0.7	-1.4
Change in fecal boli incidents, locomotor task	0.5	0.6	1.4	-1.0	-0.5	-1.2	-0.1	0.2	0.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.3	-0.4	-0.2	0.3	0.5	-0.3
Bouts of movement, locomotor time 1	0.2	0.2	0.4	-0.4	-0.5	0.3	0.4	0.7	-0.4
Total resting periods, locomotor time 1	0.6	0.6	1.3	-0.6	-0.9	0.5	0.7	1.1	-0.8
Rest time, locomotor task time 1	0.8	1.3	2.0	1.4	1.0	1.4	-1.4	-0.6	-0.7
Distance moved, locomotor task time 1	0.2	0.6	2.2	-0.6	-0.7	-1.5	0.1	0.4	0.6
Vertical activity count, locomotor time 1	0.2	1.7	5.9	-1.1	-1.0	-2.4	0.2	0.4	1.4
Time >=10cm from walls, locomotor time 2	0.3	0.8	2.7	-0.5	-0.0	-1.6	-0.5	-0.2	1.3
Bouts of movement, locomotor time 2	0.2	0.6	1.2	0.9	1.1	0.8	-0.6	-0.7	0.1
Total resting periods, locomotor time 2	0.3	1.1	1.8	1.3	1.4	1.2	-0.9	-0.8	-0.1
Rest time, locomotor task time 2	2.7	4.6	8.0	2.8	2.2	2.5	-2.2	-1.6	-1.1
Distance moved, locomotor task time 2	2.9	3.8	9.3	-2.4	-1.6	-3.1	1.2	1.0	1.7
Vertical activity count, locomotor time 2	1.8	4.2	12.1	-2.1	-0.9	-3.5	0.6	-0.1	2.7
Light reinforcement 1	0.1	0.4	0.9	-0.3	-0.5	0.5	0.9	0.5	-0.7
Light reinforcement 2	0.3	0.6	1.1	0.9	0.8	1.0	-0.6	-0.7	-0.4
Bone: marrow area	0.6	1.4	2.3	-0.4	-1.3	0.7	1.5	1.5	-1.2
Bone: maximum diameter	0.4	0.8	1.4	0.5	-0.5	1.1	0.9	0.8	-1.2
Bone: maximum force	1.7	3.3	6.5	-0.6	-2.5	0.3	1.6	2.5	-2.1
Bone: maximum moment	1.7	3.1	6.5	-0.7	-2.6	-0.0	1.3	2.5	-1.9
Mean time between licks in bursts	0.3	2.0	4.5	2.1	1.3	1.7	-1.3	-0.9	-0.8
Mean num. licks in bursts	0.5	1.3	2.6	0.9	1.3	0.0	-1.6	-1.2	0.9
Cd content in liver	0.8	0.9	1.5	1.1	1.0	1.2	-0.5	-1.1	-0.4
Co content in liver	0.8	0.9	3.2	-0.6	-1.2	-1.8	-0.2	0.6	0.2
Cu content in liver	0.5	0.5	0.9	0.7	0.8	0.2	-0.9	-1.0	0.6
Fe content in liver	0.3	0.4	1.2	-0.4	0.7	0.0	0.1	-0.7	1.1
K content in liver	2.5	2.5	4.9	0.0	-0.9	1.9	1.7	1.6	-2.2
Mg content in liver	1.2	1.4	4.0	1.4	0.4	2.0	-0.1	0.2	-1.4
Mn content in liver	3.3	3.7	10.1	-2.6	-1.5	-3.2	0.4	0.7	1.7
Na content in liver	0.4	0.4	0.8	-0.3	0.8	0.4	0.4	-0.8	0.9
Rb content in liver	0.5	0.5	1.2	-1.1	-0.7	-0.0	0.9	0.8	-0.1
Se content in liver	0.3	0.4	1.3	-0.5	0.1	-0.7	0.1	-0.1	1.1
Sr content in liver	1.2	1.0	2.3	-1.4	-0.9	-0.1	1.5	1.0	-0.3
Zn content in liver	1.9	2.2	4.6	2.1	1.6	1.5	-1.7	-1.1	-0.3
Bone: minimum diameter	1.3	2.4	5.5	0.4	-1.5	1.4	1.0	1.9	-2.4
Time in familiar zone, hab. session 1	0.3	0.3	0.7	0.1	0.6	-0.5	-0.4	-0.8	0.7
Time in novel zone, hab. session 1	0.1	0.1	0.3	0.0	-0.2	0.5	0.3	0.4	-0.4
Total zone transitions, hab. session 1	0.9	1.2	4.6	0.8	0.3	-1.1	-2.1	-0.7	0.7
Total locomotion distance, hab. session 1	18.6	26.5	53.0	7.3	5.6	3.9	-6.3	-4.4	-0.3
Locomotion velocity, hab. session 1	16.9	23.9	49.5	7.0	5.3	3.8	-5.9	-4.1	-0.6
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.2	0.5	0.2	0.4	-0.4	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.1	-0.4	-0.5	-0.5	0.1	-0.0
Total zone transitions, hab. session 2	0.2	0.3	0.8	-0.2	-0.9	-0.4	-0.1	0.7	-0.4
Total locomotion distance, hab. session 2	10.4	13.6	29.7	5.4	3.8	3.6	-4.0	-2.7	-1.2
Locomotion velocity, hab. session 2	10.0	13.3	28.7	5.4	3.8	3.5	-4.0	-2.7	-1.1
Novel to familiar place preference ratio	0.3	0.3	0.8	0.4	0.5	-0.3	-0.9	-0.6	0.7
Novelty place preference	0.3	0.3	0.8	-0.0	0.4	-0.6	-0.6	-0.6	0.9
Time in novel zone, NPP test	0.3	0.4	1.1	-0.3	0.2	-0.9	-0.5	-0.4	1.0
Total zone transitions, NPP test	0.3	0.5	1.2	0.8	-0.3	0.8	-0.5	0.4	-1.1
Total locomotion distance, NPP test	13.3	18.6	39.5	6.3	4.6	4.4	-4.4	-3.2	-1.6
Locomotion velocity, NPP test	14.2	20.2	42.7	6.5	4.8	4.6	-4.5	-3.4	-1.7
Intraocular pressure	1.4	2.3	4.1	0.9	1.6	-0.9	-2.0	-1.7	1.5
Delta distance traveled before/after self-admin	0.2	0.3	0.7	0.5	-0.2	0.7	-0.1	0.4	-0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.7	0.8	0.2	0.4	-0.7	-0.1	-0.4
Parametrial fat weight	0.6	1.4	2.6	1.5	1.3	1.6	-0.9	-0.9	-0.7
Pavlov. Cond. lever latency	0.4	0.5	0.9	0.7	1.0	0.9	0.0	-0.7	-0.3
Pavlov. Cond. magazine entry latency	0.5	0.7	1.1	0.6	1.0	-0.0	-1.0	-1.0	0.9
Pavlov. Cond. change in total contacts	0.4	0.5	1.5	-0.3	0.1	-0.9	-0.6	-0.3	1.2
Pavlov. Cond. index score	0.3	0.3	0.8	0.1	0.3	-0.6	-0.9	-0.5	0.8
Pavlov. Cond. latency score	0.1	0.1	0.3	0.1	0.1	-0.2	-0.6	-0.2	0.4
Pavlov. Cond. lever contacts	0.2	0.3	0.8	-0.4	-0.5	-0.9	-0.4	0.3	0.5
Pavlov. Cond. magazine entry number	1.4	1.8	3.9	-0.8	-1.2	0.7	2.0	1.4	-1.5
Pavlov. Cond. intertrial magazine entries	1.1	1.3	3.9	-0.4	0.2	-1.6	-1.0	-0.7	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	-0.1	0.2	-0.8	-0.8	-0.4	1.0
Pavlov. Cond. response bias	0.6	0.7	1.4	0.1	0.4	-0.9	-1.2	-0.7	1.1
Pavlov. Cond. lever latency	0.4	0.6	1.6	0.3	-0.6	0.7	0.2	0.8	-1.2
Pavlov. Cond. magazine entry latency	0.3	0.4	0.8	-0.9	-0.5	-0.6	0.7	0.2	0.8
Pavlov. Cond. change in total contacts	0.0	0.1	0.3	-0.2	0.2	-0.0	0.3	-0.3	0.6
Pavlov. Cond. index score	0.3	0.5	1.5	-0.6	0.4	-0.6	0.3	-0.6	1.2
Pavlov. Cond. latency score	0.3	0.4	1.4	-0.5	0.3	-0.6	0.2	-0.6	1.2
Pavlov. Cond. lever contacts	0.3	0.4	1.0	-0.6	0.2	-0.7	0.3	-0.4	1.0
Pavlov. Cond. magazine entry number	0.5	0.7	1.4	1.2	0.3	0.5	-1.0	-0.1	-1.1
Pavlov. Cond. intertrial magazine entries	0.7	1.6	3.3	1.8	0.8	1.7	-0.7	-0.4	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.4	1.0	-0.6	0.3	-0.4	0.5	-0.5	1.0
Pavlov. Cond. response bias	0.4	0.5	1.7	-0.7	0.2	-0.8	0.1	-0.5	1.3
Time in closed arm before self-admin	0.9	1.6	4.2	-1.6	-1.2	-0.5	2.0	1.0	0.0
Time in closed arm after self-admin	0.2	0.2	0.5	0.4	0.2	0.7	0.1	0.0	-0.6
Time in open arm before self-admin	3.2	3.9	8.5	2.9	1.7	2.1	-2.1	-1.0	-1.3
Time in open arm after self-admin	1.0	1.1	2.0	1.4	1.1	1.1	-1.0	-0.8	-0.3
Bone: periosteal estimation	1.4	3.3	5.6	-0.2	-2.0	1.1	1.9	2.3	-2.4
Bone: periosteal perimeter	0.3	0.6	1.2	1.1	-0.2	0.9	0.1	0.4	-1.0
Bone: post-yield work	0.0	0.0	0.0	0.2	-0.1	0.1	0.0	0.2	0.0
Progressive ratio test 1 active lever presses	0.3	0.6	1.6	1.3	0.8	0.5	-0.7	-0.5	-0.1
Progressive ratio test 1 breakpoint	0.4	0.6	1.8	1.4	0.8	0.7	-0.7	-0.4	-0.2
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.1	0.2	0.2	0.0	0.0	0.3
Progressive ratio test 2 active lever presses	1.1	1.5	2.6	1.1	1.1	-0.8	-1.6	-1.3	1.2
Progressive ratio test 2 breakpoint	1.2	1.6	2.7	1.2	1.2	-0.8	-1.6	-1.4	1.2
Progressive ratio test 2 inactive lever presses	0.7	2.4	3.6	1.2	1.5	-0.8	-1.9	-1.7	1.8
Incentive Sensitization - Responses	0.4	1.1	4.1	-0.6	-0.4	-2.0	-0.7	-0.1	1.3
Incentive Sensitization - Breakpoint	0.5	1.1	4.0	-0.4	-0.3	-2.0	-0.8	-0.2	1.3
Sum of active levers in priming session hrs 5-6	1.2	1.1	2.2	-1.5	-1.2	-1.3	0.5	0.9	0.3
Progressive ratio	0.6	1.8	5.3	0.7	0.3	2.3	1.3	0.3	-1.7
Food seeking constrained by brief footshock	1.6	2.0	6.0	1.4	-0.7	1.6	-0.0	1.0	-2.5
Seeking ratio, punishment vs. effort	0.1	0.3	0.9	0.3	-0.4	-0.5	-1.0	0.3	-0.1
Retroperitoneal fat weight	0.7	3.2	8.7	2.1	1.3	2.9	-0.2	-0.6	-2.0
Reaction time number correct	0.6	2.1	3.9	-1.2	-1.9	-0.0	1.6	2.0	-1.1
Reaction time mean minus median	0.2	1.4	3.0	-1.7	-0.9	-1.4	1.1	0.8	0.8
Reaction time mean minus median AUC	0.3	1.9	3.9	-2.0	-1.0	-1.9	0.9	0.8	1.2
Reaction time num false alarms	0.2	0.4	0.9	-0.9	0.1	-0.5	0.5	-0.4	0.8
Reaction time num false alarms AUC	0.1	0.3	0.9	-0.9	-0.1	-0.5	0.5	-0.3	0.6
Reaction time trials correct on left	0.6	2.1	3.9	-1.2	-1.9	-0.0	1.6	2.0	-1.1
Reaction time trials on left	0.7	2.3	4.1	-1.3	-2.0	-0.1	1.6	2.0	-1.1
Reaction time mean	1.1	2.4	4.6	-2.1	-1.9	-1.8	1.2	1.3	0.3
Reaction time mean AUC	0.9	2.1	3.9	-2.0	-1.7	-1.8	1.1	1.2	0.3
Median of all reaction times	1.5	2.4	4.2	-2.1	-2.0	-1.7	1.2	1.3	0.1
Reaction time omissions	2.8	4.5	10.7	-3.3	-2.2	-2.3	2.0	1.4	0.7
Reaction time false alarm rate	0.8	1.1	2.7	0.0	1.3	-0.4	-0.7	-1.6	1.4
Reaction time premature initiation rate	2.5	3.8	8.3	-2.9	-1.3	-2.8	1.3	0.6	1.9
Reaction time premature initiations	1.7	5.3	11.3	-3.4	-2.4	-2.4	2.2	1.8	0.9
Std. dev. reaction times	0.5	1.7	3.3	-1.8	-1.4	-1.4	1.2	1.2	0.2
Reaction time trials completed	0.7	2.3	4.1	-1.3	-2.0	-0.1	1.6	2.0	-1.1
Reaction time trials AUC	0.6	2.1	3.8	-1.2	-2.0	-0.2	1.5	1.9	-1.0
Run reversals in cocaine runway, females	0.8	0.9	2.3	-1.5	-1.0	-0.4	1.0	1.0	-0.4
Run reversals in cocaine runway, males	0.9	1.0	2.0	0.1	-1.1	0.7	0.8	1.3	-1.4
Latency to leave start box in cocaine runway	1.5	2.0	5.8	0.7	0.1	2.4	1.0	0.8	-2.0
Latency to leave start box in cocaine runway, F	1.1	1.3	3.4	0.0	-0.1	1.9	1.3	0.8	-1.5
Latency to leave start box in cocaine runway, M	1.0	1.0	2.4	1.2	0.5	1.6	-0.1	0.0	-1.3
Std. dev. time between licks in bursts	0.9	1.6	3.5	1.5	1.3	0.1	-1.9	-1.4	0.5
Total sessions with >9 infusions	0.1	0.1	0.2	0.4	0.4	0.4	0.1	-0.2	-0.0
Short access day 1 total inactive lever presses	0.4	0.8	1.9	0.8	1.2	1.4	-0.2	-1.0	-0.0
Short access day 10 total inactive lever presses	0.1	0.7	2.2	0.7	0.2	1.5	0.2	0.4	-1.2
Short access day 1 total infusions	0.1	0.1	0.3	-0.4	-0.0	-0.3	0.2	0.1	0.5
Short access day 10 total infusions	0.2	0.3	0.6	0.1	0.6	-0.3	-0.5	-0.5	0.8
Short access total infusions	0.1	0.2	0.4	0.2	0.5	-0.2	-0.3	-0.4	0.6
Short access day 1 locomotion	0.4	0.7	1.6	1.3	0.6	1.2	-0.5	-0.3	-0.8
Short access day 10 total locomotion	0.4	1.7	3.1	1.7	1.5	1.8	-0.5	-1.1	-0.5
Short access total locomotion	0.8	1.1	2.4	1.6	1.2	1.4	-0.5	-0.7	-0.6
One hour access (0.3 mA shock)	1.8	2.2	4.2	1.6	1.4	-0.8	-2.0	-1.6	1.1
Compulsive drug intake	0.8	1.2	2.1	1.4	1.2	1.4	-1.0	-0.8	-0.6
One hour access (shock baseline)	0.3	0.7	3.1	-0.2	-0.4	-1.8	-0.6	-0.0	0.9
Social response proportion	0.4	0.5	1.4	-0.6	-0.9	-0.1	1.2	0.6	-0.4
Social responses	0.9	1.1	2.5	0.5	-0.6	1.4	1.1	0.8	-1.6
Social time	2.2	3.4	5.6	-1.9	-2.4	-0.9	2.2	2.1	-1.0
Soleus weight	0.2	0.6	1.5	-1.2	-0.6	-0.9	0.6	0.3	0.6
Bone: stiffness	1.2	2.1	3.7	-0.3	-1.8	0.5	1.6	1.9	-1.8
Tibialis anterior weight	1.7	5.8	10.2	-3.2	-3.1	-2.1	2.1	2.6	0.2
Time to tail flick, vehicle, before self-admin	0.8	1.0	2.3	-0.4	0.8	-0.9	-0.7	-1.2	1.5
Time to tail flick, vehicle, after self-admin	1.1	2.3	5.9	2.0	1.4	2.4	-0.3	-0.8	-1.2
Time to tail flick, test, before self-admin	0.6	0.7	2.6	0.9	0.6	-0.2	-1.6	-0.6	0.3
Time to tail flick, test, after self-admin	0.9	1.0	2.5	1.0	1.0	1.6	-0.3	-0.6	-0.8
Delta time to tail flick, vehicle, before/after SA	1.5	1.6	2.8	-0.5	-1.2	0.8	1.7	1.5	-1.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.6	-0.1	0.2	0.7	0.8	-0.1	-0.4
Tibia length	0.1	0.4	1.1	0.2	-1.0	-0.3	-0.1	0.8	-0.6
Ambulatory time before self-admin	0.6	2.0	3.2	-1.2	-1.7	0.2	1.6	1.8	-1.2
Ambulatory time after self-admin	0.5	0.8	1.7	-0.6	-1.2	-0.1	0.6	1.3	-0.9
Bone: tissue strength	1.1	1.1	2.7	0.4	-0.6	1.3	0.9	1.0	-1.6
Total heroin consumption	0.4	0.5	0.8	0.2	0.7	-0.3	-0.8	-0.9	0.9
Bone: trabecular number	0.9	1.8	3.2	-1.3	-1.7	-0.1	1.4	1.8	-0.9
Bone: trabecular spacing	0.1	0.2	0.4	0.5	0.6	0.0	-0.6	-0.5	0.1
Bone: trabecular thickness	0.3	0.4	0.9	-0.7	-0.9	-0.8	0.1	0.7	0.3
Bone: trabecular tissue density	0.8	1.4	2.9	0.3	-0.9	1.3	0.6	1.4	-1.7
Water consumed over 24 hours	0.3	0.5	1.0	-1.0	-0.6	-1.0	0.3	0.5	0.7
Number of responses in last shaping day	0.4	0.5	1.0	0.8	0.9	1.0	0.0	-0.7	0.1