Hub : Genes

Pdcl2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Pdcl2	0.04	0.02	1.8e-05	0.04	0.04	0.02	0.03	2.7e-05	1.7e-05	8.9e-04	3.1e-04
2	Brain	mRNA stability	Pdcl2	0.16	0.12	1.8e-03	0.07	0.04	0.06	0.06	5.3e-07	7.2e-05	5.7e-06	1.2e-06
3	PL	intron excision ratio	chr14_31889055_31895084	0.03	0.03	7.3e-03	0	0.01	0	0	7.6e-02	5.9e-02	2.6e-01	2.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.8	1.4	2.8	-0.7	1.7	-1.0
Area under the delay curve	0.3	0.3	0.9	-1.0	0.1	-0.1
BMI with tail	0.2	0.6	0.8	0.6	0.8	-0.9
BMI without tail	0.6	1.3	2.2	0.5	1.5	-1.2
Body weight	0.4	1.9	3.6	0.4	1.9	-1.4
Weight adjusted by age	0.5	0.5	1.3	0.5	-0.1	-1.1
Bone surface	0.3	0.6	1.2	-0.2	1.1	-0.7
Bone volume	0.5	0.8	1.2	0.1	1.1	-1.1
Breakpoint value in progressive ratio session	0.9	1.0	1.9	-1.0	0.2	1.4
Number of licking bursts	0.5	0.6	1.1	-0.1	0.8	-1.1
Context. condit. distance diff. score	2.8	3.3	6.0	2.4	-0.4	-2.0
Locomotion velocity, session 1	0.3	0.3	0.5	0.6	-0.4	-0.7
Locomotion distance, session 1	0.2	0.3	0.5	0.7	-0.6	-0.0
Locomotion velocity, session 2	0.4	0.4	0.7	-0.6	-0.5	0.9
Locomotion distance, session 2	1.5	2.2	3.4	-1.5	-0.9	1.9
Locomotion velocity, session 3	0.6	0.7	1.3	1.1	0.6	-0.7
Locomotion distance, session 3	0.8	0.9	2.3	1.5	-0.4	-0.5
Stereotopy head waving bouts, day 3	1.2	1.4	2.9	-0.6	-1.7	1.0
Stereotopy head waving duration, day 3	4.8	5.8	14.3	1.7	-3.8	0.5
Locomotion velocity, session 7	2.7	2.9	5.5	1.8	-0.2	-2.3
Locomotion distance, session 7	2.9	3.7	5.9	2.4	-2.0	-0.9
Stereotopy head waving bouts, day 7	3.2	3.6	9.1	1.3	-3.0	0.0
Stereotopy head waving duration, day 7	2.0	2.4	5.7	-2.4	0.5	1.1
Locomotion velocity, session 8	0.2	0.2	0.4	-0.6	0.3	0.3
Locomotion distance, session 8	0.9	1.4	2.3	1.5	-1.2	-0.6
Degree of sensitization distance	1.2	1.2	1.8	1.4	-1.1	-0.8
Degree of sensitization stereotypy	1.0	1.1	2.6	-1.6	0.8	0.4
Conditioned locomotion	0.7	0.8	1.6	-0.7	-1.3	0.5
Cocaine response after cond. corrected	0.6	0.6	1.1	-0.6	-1.1	0.6
Cocaine response after cond. not corrected	0.2	0.3	0.7	-0.3	-0.8	0.3
Cocaine response before conditioning	0.2	0.2	0.3	0.5	0.3	-0.5
Saline control response	0.7	0.9	1.9	0.1	0.9	-1.4
Bone: connectivity density	1.5	2.4	5.1	-2.3	1.2	0.9
Bone: cortical apparent density	2.3	3.1	8.3	-0.8	2.9	-0.6
Bone: cortical area	1.9	2.9	5.5	0.9	1.5	-2.3
Bone: cortical porosity	0.7	0.7	1.9	-1.4	-0.3	0.4
Bone: cortical porosity	0.6	0.7	2.0	-1.4	0.1	-0.1
Bone: cortical thickness	2.3	3.8	7.1	1.0	1.8	-2.7
Bone: cortical thickness	0.1	0.2	0.3	-0.3	-0.2	-0.6
Bone: cortical tissue density	2.2	2.9	7.8	-0.7	2.8	-0.6
Condit. Reinf. active minus inactive responses	1.0	1.1	1.8	-0.0	-1.4	1.2
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.5	-0.7	0.0
Condit. Reinf. active responses	1.7	2.1	3.6	-0.6	-1.5	1.9
Condit. Reinf. inactive responses	0.6	0.8	1.8	-0.7	-0.1	1.3
Incentive salience index mean	0.8	1.0	2.0	-0.8	-0.6	1.4
Condit. Reinf. lever presses	1.4	1.8	2.8	-1.7	0.8	1.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.7	-0.0	0.1	-0.8
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.3	0.2	-0.6
Condit. Reinf. active responses	0.4	0.6	1.1	0.6	0.4	-1.1
Condit. Reinf. inactive responses	0.8	1.0	2.1	1.5	0.3	-0.8
Condit. Reinf. lever presses	0.3	0.4	1.0	-1.0	0.4	0.4
Condit. Reinf. lever reinforcers received	0.2	0.2	0.4	0.3	0.5	-0.6
Conditioned reinforcement - actives	0.1	0.1	0.2	0.2	0.5	-0.1
Conditioned reinforcement - inactives	1.7	1.9	2.9	-1.2	-1.2	1.7
Conditioned locomotion	0.2	0.2	0.5	0.3	0.4	-0.7
Patch foraging indifference point 0 sec	1.3	2.0	4.7	2.2	-0.2	-1.1
Patch foraging indifference point AUC	1.2	1.4	4.2	2.0	-0.2	-0.2
Delay disc. indifference point, 0s delay	0.3	0.3	0.5	-0.7	-0.7	0.2
Delay disc. indifference point, 16s delay	0.9	0.9	1.7	-1.3	0.9	0.0
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.2	0.0	-0.5
Delay disc. indifference point, 24s delay	1.2	1.1	3.0	-0.7	1.7	0.1
Delay disc. indifference point, 4s delay	0.5	0.6	1.1	-1.0	-0.7	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.6	-0.2	0.1
Indifference point function ln k	0.8	1.2	2.4	-1.6	-0.8	0.6
Indifference point function log k	0.8	1.2	2.4	-1.6	-0.8	0.6
Patch foraging total patch changes 0 sec	2.1	3.4	7.6	2.8	-0.1	-1.6
Patch foraging total patch changes 12 sec	0.9	1.2	2.6	1.6	0.5	-0.8
Patch foraging total patch changes 18 sec	2.9	3.8	8.0	2.8	-0.3	-1.8
Patch foraging total patch changes 24 sec	2.3	2.8	6.2	2.5	0.6	-1.4
Patch foraging total patch changes 6 sec	1.6	2.4	6.0	2.5	0.1	-1.0
Patch foraging time to switch 0 sec	1.3	2.0	3.0	-1.7	1.7	0.0
Patch foraging water rate 0 sec	0.9	1.5	3.9	0.8	-2.0	0.2
Patch foraging water rate 12 sec	1.4	2.2	6.5	0.2	-2.6	0.1
Patch foraging water rate 18 sec	1.2	1.6	2.9	-1.2	-0.7	1.7
Patch foraging water rate 24 sec	0.3	0.5	0.7	-0.6	-0.9	0.6
Patch foraging water rate 6 sec	1.3	1.9	5.1	0.0	-2.3	0.8
Seeking ratio, delayed vs. immediate footshock	1.8	2.1	4.2	-1.4	-0.3	2.1
Distance traveled before self-admin	1.2	1.3	2.0	0.3	1.3	-1.4
Distance traveled after self-admin	0.4	0.5	0.8	0.1	0.8	-0.9
Extensor digitorum longus weight	1.1	4.3	9.0	-3.0	2.0	0.2
Bone: elastic displacement	0.2	0.2	0.5	0.1	-0.7	-0.4
Bone: elastic work	0.2	0.2	0.6	0.1	-0.1	-0.8
Bone: endosteal estimation	0.3	0.6	1.1	0.5	0.6	-1.0
Bone: endosteal perimeter	0.0	0.1	0.1	0.3	-0.3	-0.3
Epididymis fat weight	0.4	1.0	2.8	1.7	0.4	-0.3
Delta time in closed arm before/after self-admin	0.5	0.5	1.3	1.1	0.2	-0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.4	0.2	-0.1
Diff in mean of infusions in LGA sessions	0.6	0.7	1.4	-0.7	-0.4	1.2
Delay discount exponential model param	0.2	0.3	0.5	0.7	-0.3	0.4
Extinction: sum of active levers before priming	0.9	0.9	1.6	0.3	-0.9	1.3
Active lever presses in extinction session 6	0.1	0.1	0.2	0.4	-0.0	0.3
Bone: final force	1.0	1.6	2.8	-0.6	1.3	-1.7
Bone: final moment	0.9	1.4	2.2	-0.9	1.1	-1.5
Food consumed during 24 hour testing period	0.5	0.6	1.2	0.3	-1.1	0.6
Glucose	0.0	0.0	0.0	-0.1	-0.1	-0.0
Heart weight	0.2	0.3	0.5	-0.1	-0.6	0.7
Delay discount hyperbolic model param	0.2	0.2	0.6	0.8	-0.1	0.3
Intermittent access intake day 1-15 change	1.0	1.0	2.1	-1.5	0.3	0.9
Intermittent access intake escalation	0.8	0.8	1.5	-1.2	0.2	0.8
Intermittent access intake escalation 2	1.7	1.6	3.3	-1.8	-0.4	1.2
Intermitt. access day 1 inactive lever presses	3.3	3.5	8.0	2.8	-0.8	-1.3
Intermitt. access day 15 inactive lever presses	1.1	1.2	2.5	-0.6	-0.8	1.6
Intermitt. access escalation Index	0.5	0.4	1.1	0.3	-1.0	-0.4
Intermittent access day 1 total infusions	1.3	1.5	2.6	-0.5	-1.6	1.3
Intermittent access day 15 total infusions	2.6	3.0	3.6	-1.7	-1.5	1.9
Intermittent access terminal intake (last 3 days)	4.9	5.4	6.1	-2.3	-2.2	2.5
Intermittent access total infusions	1.7	1.8	2.2	-1.4	-1.2	1.5
Intermittent access day 1 locomotion	0.7	0.7	1.8	0.4	-1.4	0.4
Intermittent access day 15 total locomotion	1.5	1.6	2.5	-1.0	-1.2	1.6
Intermittent access total locomotion	0.2	0.2	0.5	-0.2	-0.7	0.3
Intermittent access standard deviation	0.2	0.2	0.3	-0.5	0.5	0.1
Left kidney weight	1.8	5.0	10.7	0.4	3.3	-2.1
Right kidney weight	0.6	1.7	1.9	1.2	1.4	-1.3
Cocaine induced anxiety	0.3	0.3	0.8	-0.9	0.3	-0.1
Post-drug Anxiety	0.5	0.6	1.5	0.1	1.2	-0.5
Baseline Anxiety	0.1	0.1	0.3	0.0	0.2	0.6
Tail length	0.5	1.6	2.6	0.4	1.6	-1.4
Length with tail	0.3	1.1	2.3	0.4	1.5	-0.9
Length without tail	0.3	0.6	0.9	0.6	1.0	-0.7
Times rat made contact with spout	0.1	0.2	0.3	0.1	0.4	-0.5
Lifetime Intake	1.2	1.3	1.9	-1.3	-0.5	1.4
Liver weight, left	0.2	0.4	0.9	0.9	0.1	-0.4
Liver weight, right	0.3	0.5	1.5	-0.2	1.2	0.3
Locomotor activity	3.0	4.8	8.8	3.0	-2.0	-1.2
Locomotor testing distance	2.6	4.3	8.0	2.8	-1.5	-1.6
Locomotor testing rearing	1.2	1.8	4.3	2.1	-0.0	-1.1
Locomotion in novel chamber	2.1	2.7	3.4	-1.5	-1.8	1.6
Locomotion in novel chamber post-restriction	0.2	0.3	0.4	0.5	0.4	-0.6
Fecal boli incidents, locomotor time 1	2.1	2.3	4.7	2.2	-0.6	-1.3
Change in fecal boli incidents, locomotor task	0.9	0.8	1.7	-1.3	-0.1	0.9
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	-0.2	0.3	-0.3
Bouts of movement, locomotor time 1	0.1	0.1	0.1	0.4	-0.1	-0.3
Total resting periods, locomotor time 1	0.3	0.3	0.6	0.5	0.3	-0.7
Rest time, locomotor task time 1	1.0	1.1	2.0	1.4	-1.0	-0.5
Distance moved, locomotor task time 1	0.9	1.0	2.4	-1.5	0.2	0.7
Vertical activity count, locomotor time 1	2.6	2.8	6.0	-2.4	-0.5	1.4
Time >=10cm from walls, locomotor time 2	1.3	1.4	2.4	-1.5	-0.1	1.4
Bouts of movement, locomotor time 2	0.4	0.4	0.8	0.9	-0.7	0.1
Total resting periods, locomotor time 2	0.8	0.9	1.7	1.3	-1.0	-0.2
Rest time, locomotor task time 2	3.8	4.3	6.8	2.6	-2.2	-1.1
Distance moved, locomotor task time 2	4.2	4.9	9.5	-3.1	1.4	1.7
Vertical activity count, locomotor time 2	5.8	6.4	12.0	-3.5	0.2	2.7
Light reinforcement 1	0.2	0.4	0.5	0.6	0.5	-0.7
Light reinforcement 2	0.6	0.9	1.3	1.1	-1.0	-0.5
Bone: marrow area	0.2	0.5	0.9	0.4	0.6	-1.0
Bone: maximum diameter	0.4	0.7	1.0	1.0	0.3	-1.0
Bone: maximum force	1.1	1.9	4.1	0.2	1.2	-2.0
Bone: maximum moment	0.9	1.5	3.3	-0.1	1.1	-1.8
Mean time between licks in bursts	1.3	1.9	3.9	2.0	-0.8	-1.0
Mean num. licks in bursts	0.5	0.6	1.1	0.2	-1.1	0.8
Cd content in liver	0.2	0.2	0.2	0.5	-0.4	0.4
Co content in liver	1.3	1.5	4.0	-2.0	0.4	0.6
Cu content in liver	0.1	0.1	0.3	0.4	-0.1	0.5
Fe content in liver	1.6	1.9	3.4	-0.3	-1.8	1.5
K content in liver	4.1	4.1	4.7	2.0	1.9	-2.2
Mg content in liver	1.8	1.8	3.8	1.9	0.1	-1.3
Mn content in liver	3.2	3.7	7.8	-2.8	1.3	1.2
Na content in liver	0.8	0.9	2.2	-0.6	-0.1	1.5
Rb content in liver	0.1	0.1	0.3	-0.2	0.5	-0.0
Se content in liver	1.0	1.2	2.0	-1.1	-0.7	1.4
Sr content in liver	0.8	0.7	2.1	0.2	1.4	-0.3
Zn content in liver	0.3	0.3	0.7	0.2	-0.8	0.4
Bone: minimum diameter	1.2	2.2	4.3	1.2	1.1	-2.1
Time in familiar zone, hab. session 1	0.6	0.6	1.3	-0.4	-1.1	0.5
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.5	0.5	-0.4
Total zone transitions, hab. session 1	0.6	0.9	1.2	-1.1	-1.1	0.7
Total locomotion distance, hab. session 1	12.7	18.1	36.7	4.2	-6.1	-0.5
Locomotion velocity, hab. session 1	10.7	15.1	28.4	4.1	-5.3	-0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.3	0.1	0.1	0.5
Time in novel zone, hab. session 2	0.1	0.1	0.2	-0.5	-0.3	-0.1
Total zone transitions, hab. session 2	0.2	0.2	0.3	-0.3	0.6	-0.5
Total locomotion distance, hab. session 2	7.4	9.8	14.3	3.8	-3.7	-1.3
Locomotion velocity, hab. session 2	6.9	9.3	13.7	3.7	-3.5	-1.2
Novel to familiar place preference ratio	1.0	1.0	2.7	-0.2	-1.7	0.6
Novelty place preference	1.1	1.1	2.3	-0.6	-1.5	0.8
Time in novel zone, NPP test	1.2	1.3	2.0	-0.9	-1.4	1.0
Total zone transitions, NPP test	0.5	0.7	1.5	0.7	0.4	-1.2
Total locomotion distance, NPP test	9.7	13.2	21.0	4.6	-4.0	-1.7
Locomotion velocity, NPP test	10.4	14.7	23.3	4.8	-4.2	-1.8
Intraocular pressure	1.8	2.5	4.7	-0.7	-2.2	1.5
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.5	-0.0	-0.4
Delta ambulatory time before/after self-admin	0.2	0.3	0.6	0.3	-0.8	0.1
Parametrial fat weight	0.9	1.8	4.8	2.2	-0.6	-0.6
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.6	-0.7	-0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.5	-0.0	-0.6	0.7
Pavlov. Cond. change in total contacts	0.7	0.8	1.5	-0.9	0.3	1.2
Pavlov. Cond. index score	0.2	0.3	0.6	-0.5	-0.1	0.8
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.2	0.2	0.4
Pavlov. Cond. lever contacts	0.4	0.5	0.9	-1.0	0.6	0.4
Pavlov. Cond. magazine entry number	1.3	1.6	2.3	0.5	1.5	-1.5
Pavlov. Cond. intertrial magazine entries	1.8	2.2	3.7	-1.5	-0.8	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	-0.8	-0.1	1.0
Pavlov. Cond. response bias	0.6	0.7	1.1	-0.9	-0.3	1.1
Pavlov. Cond. lever latency	0.4	0.6	1.0	0.6	0.5	-1.0
Pavlov. Cond. magazine entry latency	0.3	0.3	0.5	-0.5	0.4	0.7
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.1	0.4	0.6
Pavlov. Cond. index score	0.5	0.6	1.3	-0.6	0.2	1.1
Pavlov. Cond. latency score	0.4	0.5	1.2	-0.6	0.1	1.1
Pavlov. Cond. lever contacts	0.3	0.4	0.7	-0.7	-0.0	0.9
Pavlov. Cond. magazine entry number	0.4	0.5	1.0	0.5	-0.6	-1.0
Pavlov. Cond. intertrial magazine entries	1.1	1.5	2.7	1.6	0.1	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.3	0.5	0.9
Pavlov. Cond. response bias	0.6	0.8	1.6	-0.8	-0.1	1.3
Time in closed arm before self-admin	0.4	0.5	1.2	-0.2	1.1	-0.5
Time in closed arm after self-admin	0.6	0.6	0.7	0.7	0.8	-0.7
Time in open arm before self-admin	2.0	2.1	3.0	1.7	-1.7	-0.7
Time in open arm after self-admin	0.5	0.5	1.1	0.8	-1.0	0.0
Bone: periosteal estimation	1.2	2.4	4.5	0.9	1.4	-2.1
Bone: periosteal perimeter	0.3	0.5	0.8	0.8	-0.1	-0.9
Bone: post-yield work	0.0	0.0	0.1	-0.1	-0.2	0.3
Progressive ratio test 1 active lever presses	0.3	0.3	0.4	-0.6	-0.4	0.5
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	-0.3	-0.5	0.3
Progressive ratio test 1 inactive lever presses	0.3	0.4	0.7	-0.2	-0.6	0.8
Progressive ratio test 2 active lever presses	1.5	1.6	1.8	-1.3	-1.1	1.3
Progressive ratio test 2 breakpoint	0.9	1.0	1.0	-1.0	-1.0	1.0
Progressive ratio test 2 inactive lever presses	3.4	3.9	5.3	-1.3	-2.2	2.3
Incentive Sensitization - Responses	1.8	1.8	3.9	-2.0	-0.0	1.2
Incentive Sensitization - Breakpoint	1.7	1.7	3.7	-1.9	-0.2	1.2
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.6	0.4	-0.1
Progressive ratio	2.8	3.2	4.9	2.2	0.9	-2.0
Food seeking constrained by brief footshock	2.3	2.8	6.1	1.5	-0.1	-2.5
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	-0.7	-0.5	0.1
Retroperitoneal fat weight	0.4	1.3	2.6	1.6	0.8	-0.9
Reaction time number correct	0.6	0.9	1.4	-0.0	1.2	-1.2
Reaction time mean minus median	1.3	1.7	2.2	-1.5	1.5	0.9
Reaction time mean minus median AUC	1.8	2.4	4.0	-2.0	1.2	1.3
Reaction time num false alarms	0.2	0.2	0.4	-0.4	-0.2	0.7
Reaction time num false alarms AUC	0.1	0.1	0.2	-0.4	-0.2	0.5
Reaction time trials correct on left	0.6	0.9	1.4	-0.0	1.2	-1.2
Reaction time trials on left	0.7	1.0	1.6	-0.1	1.3	-1.2
Reaction time mean	1.8	2.6	4.0	-1.9	2.0	0.4
Reaction time mean AUC	1.8	2.4	3.6	-1.9	1.9	0.4
Median of all reaction times	1.7	2.3	3.9	-1.7	2.0	0.2
Reaction time omissions	3.3	4.5	9.5	-2.0	3.1	0.3
Reaction time false alarm rate	0.7	1.0	1.7	-0.3	-1.1	1.3
Reaction time premature initiation rate	3.2	4.3	7.6	-2.8	1.4	1.8
Reaction time premature initiations	2.7	3.8	5.7	-2.4	2.2	0.9
Std. dev. reaction times	1.2	1.6	2.6	-1.5	1.6	0.3
Reaction time trials completed	0.7	1.0	1.6	-0.1	1.3	-1.2
Reaction time trials AUC	0.6	0.9	1.3	-0.2	1.1	-1.1
Run reversals in cocaine runway, females	0.3	0.2	0.4	-0.5	0.7	-0.3
Run reversals in cocaine runway, males	1.0	0.9	2.1	0.7	0.5	-1.4
Latency to leave start box in cocaine runway	2.5	2.7	4.3	2.1	0.9	-1.7
Latency to leave start box in cocaine runway, F	0.9	1.0	1.6	1.3	0.8	-0.8
Latency to leave start box in cocaine runway, M	1.8	1.7	3.5	1.9	-0.3	-1.2
Std. dev. time between licks in bursts	0.6	0.7	1.6	-0.0	-1.3	0.7
Total sessions with >9 infusions	0.3	0.3	0.8	-0.3	-0.2	0.9
Short access day 1 total inactive lever presses	1.1	1.2	1.8	1.3	-1.3	0.5
Short access day 10 total inactive lever presses	1.6	1.7	3.9	2.0	0.1	-1.1
Short access day 1 total infusions	0.7	0.7	1.2	-0.8	0.5	1.1
Short access day 10 total infusions	1.2	1.3	2.4	-1.2	-0.3	1.5
Short access total infusions	0.4	0.5	0.9	-0.6	0.1	1.0
Short access day 1 locomotion	0.1	0.1	0.2	0.5	-0.4	0.0
Short access day 10 total locomotion	0.3	0.3	0.6	0.8	-0.5	-0.1
Short access total locomotion	0.3	0.3	0.7	0.8	-0.4	-0.1
One hour access (0.3 mA shock)	1.9	2.3	2.6	-1.3	-1.6	1.6
Compulsive drug intake	1.1	1.2	2.4	1.6	-0.6	-0.8
One hour access (shock baseline)	2.0	2.4	4.8	-2.2	-0.2	1.5
Social response proportion	1.4	1.6	4.5	-0.3	2.1	-0.3
Social responses	1.9	2.4	3.3	1.3	1.8	-1.5
Social time	1.6	2.2	4.7	-0.9	2.2	-0.9
Soleus weight	0.2	0.5	1.2	-1.1	0.1	0.6
Bone: stiffness	1.0	1.6	3.2	0.4	1.3	-1.8
Tibialis anterior weight	0.7	2.5	4.3	-2.1	1.8	0.3
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.3	-0.6	0.0	1.2
Time to tail flick, vehicle, after self-admin	2.5	2.7	6.1	2.5	-0.4	-1.4
Time to tail flick, test, before self-admin	0.4	0.4	0.9	0.4	-1.0	0.2
Time to tail flick, test, after self-admin	0.6	0.7	1.4	1.2	-0.5	-0.6
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	0.2	1.0	-0.9
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	0.1	0.0
Tibia length	0.1	0.4	0.7	-0.3	0.8	-0.6
Ambulatory time before self-admin	2.0	2.1	3.8	0.2	1.9	-1.5
Ambulatory time after self-admin	0.7	0.8	1.4	-0.3	1.2	-0.9
Bone: tissue strength	1.4	1.4	2.3	1.1	0.9	-1.5
Total heroin consumption	0.2	0.2	0.6	-0.1	-0.1	0.8
Bone: trabecular number	0.5	0.7	1.6	-0.2	1.3	-0.7
Bone: trabecular spacing	0.1	0.1	0.4	0.1	-0.6	-0.0
Bone: trabecular thickness	0.2	0.3	0.6	-0.7	0.1	0.6
Bone: trabecular tissue density	1.3	1.8	2.8	1.3	1.0	-1.7
Water consumed over 24 hours	0.7	0.9	1.6	-1.3	-0.1	1.0
Number of responses in last shaping day	0.7	0.7	1.0	0.8	-1.0	0.7